DE68929030T2 - Optisch aktive Pyridoncarbonsäure-Derivate - Google Patents
Optisch aktive Pyridoncarbonsäure-DerivateInfo
- Publication number
- DE68929030T2 DE68929030T2 DE68929030T DE68929030T DE68929030T2 DE 68929030 T2 DE68929030 T2 DE 68929030T2 DE 68929030 T DE68929030 T DE 68929030T DE 68929030 T DE68929030 T DE 68929030T DE 68929030 T2 DE68929030 T2 DE 68929030T2
- Authority
- DE
- Germany
- Prior art keywords
- acid derivatives
- pyridonecarboxylic acid
- optically active
- active pyridonecarboxylic
- halogenocydopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10462588 | 1988-04-27 | ||
JP29698488 | 1988-11-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE68929030D1 DE68929030D1 (de) | 1999-08-19 |
DE68929030T2 true DE68929030T2 (de) | 2000-03-23 |
Family
ID=26445063
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE68929030T Expired - Lifetime DE68929030T2 (de) | 1988-04-27 | 1989-04-26 | Optisch aktive Pyridoncarbonsäure-Derivate |
Country Status (26)
Country | Link |
---|---|
US (4) | US5587386A (de) |
EP (1) | EP0341493B1 (de) |
JP (5) | JP2714597B2 (de) |
KR (1) | KR0184614B1 (de) |
CN (1) | CN1033751C (de) |
AT (1) | ATE182145T1 (de) |
AU (1) | AU625414B2 (de) |
BG (1) | BG61122B2 (de) |
CA (1) | CA1340801C (de) |
DE (1) | DE68929030T2 (de) |
DK (1) | DK175467B1 (de) |
ES (1) | ES2135372T3 (de) |
FI (1) | FI96947C (de) |
GR (1) | GR3031365T3 (de) |
HK (1) | HK1002108A1 (de) |
HU (1) | HU211136A9 (de) |
IL (1) | IL90062A (de) |
LV (1) | LV10092B (de) |
MY (1) | MY105136A (de) |
NO (1) | NO175939C (de) |
NZ (1) | NZ228893A (de) |
PT (1) | PT90377B (de) |
RU (1) | RU2075475C1 (de) |
SG (1) | SG48036A1 (de) |
UA (1) | UA29378C2 (de) |
YU (1) | YU48432B (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL90062A (en) * | 1988-04-27 | 1994-10-07 | Daiichi Seiyaku Co | History of pyridonecarboxylic acid, their preparation and pharmaceutical preparations containing them |
JPH0674261B2 (ja) * | 1988-06-21 | 1994-09-21 | 塩野義製薬株式会社 | キノロンカルボン酸誘導体 |
CA1336090C (en) * | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
EP0443498A1 (de) * | 1990-02-19 | 1991-08-28 | Kyorin Pharmaceutical Co., Ltd. | Isoindolinderivate |
MY109714A (en) * | 1990-10-18 | 1997-04-30 | Daiichi Seiyaku Co | Process for preparing 8-chloroquinolone derivatives |
US5696132A (en) * | 1991-05-28 | 1997-12-09 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivatives |
DE69230005T2 (de) * | 1991-06-19 | 2000-01-05 | Pfizer | Azaspirochinolone als antibakterielle Wirkstoffe |
KR960011370B1 (ko) * | 1991-12-31 | 1996-08-22 | 재단법인 한국화학연구소 | 스피로알킬아민 유도체와 그의 제조방법 |
NO301165B1 (no) * | 1992-12-25 | 1997-09-22 | Daiichi Seiyaku Co | Bicykliske aminderivater og antibakterielle midler inneholdende disse |
ZA946853B (en) * | 1993-09-10 | 1995-04-24 | Daiichi Seiyaku Co | Crystals of antimicrobial compound. |
AU683569B2 (en) * | 1994-07-18 | 1997-11-13 | Sankyo Company Limited | Trifluoromethylquinolinecarboxylic acid derivative |
DE69627985T2 (de) * | 1995-02-02 | 2004-02-19 | Daiichi Pharmaceutical Co., Ltd. | Heterozyklische verbindungen |
DE69628158T2 (de) | 1995-02-07 | 2004-03-25 | Daiichi Pharmaceutical Co., Ltd. | Heterocyclische spiroderivate |
JPH09124556A (ja) | 1995-08-30 | 1997-05-13 | Dai Ichi Seiyaku Co Ltd | ハロゲン化シクロプロパン誘導体の製造方法 |
NZ322202A (en) * | 1995-11-22 | 2000-05-26 | Daiichi Pharmaceutical Company | Aminocycloalkylpyrrolidine derivatives and salts thereof with antibacterial activity |
US6121285A (en) * | 1995-11-22 | 2000-09-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives |
ES2188890T3 (es) * | 1996-02-09 | 2003-07-01 | Toyama Chemical Co Ltd | Derivados del acido quinoleincarboxilico y sus sales. |
TW425394B (en) * | 1996-04-24 | 2001-03-11 | Daiichi Seiyaku Co | Antimicrobial quinolone derivatives having 3-(N-cycloalkyl) aminomethylpyrrolidine group |
AU1040597A (en) * | 1996-12-04 | 1998-06-29 | Daiichi Pharmaceutical Co., Ltd. | Substituted aminomethylpyrrolidine derivatives |
DK1134219T3 (da) | 1998-11-24 | 2005-10-17 | Daiichi Seiyaku Co | Cucloalkylsubstituerede aminomethylpyrrolidinderivater |
ATE268329T1 (de) * | 1999-03-10 | 2004-06-15 | Daiichi Seiyaku Co | Aminomethylpyrrolidin-derivate mit aromatischen substituenten |
CN1343128B (zh) | 1999-03-17 | 2010-04-21 | 第一制药株式会社 | 药物组合物 |
CN1312131C (zh) * | 2000-02-09 | 2007-04-25 | 第一制药株式会社 | 包含作为活性成分的吡啶酮羧酸的抗耐酸细菌药 |
AR027761A1 (es) | 2000-03-31 | 2003-04-09 | Daiichi Seiyaku Co | Un derivado del acido quinolonacarboxilico, las composiciones antibacterianas que lo contienen y el uso de dicho derivado para la elaboracion de drogaspara el tratamiento de enfermedades infecciosas |
JP5027975B2 (ja) | 2000-04-24 | 2012-09-19 | 第一三共株式会社 | 安定化液状製剤 |
MXPA03001206A (es) | 2000-08-08 | 2003-06-30 | Daiichi Pharmaceutical Co Ltd | Preparacion solida altamente absorbible. |
US20050143407A1 (en) * | 2002-05-17 | 2005-06-30 | Daiichi Pharmaceutical Co., Ltd | Process for porducing quinolonecarboxylic acid derivative |
US7199260B2 (en) * | 2003-01-07 | 2007-04-03 | Daiichi Pharmaceutical Co., Ltd. | Process for reductive dehalogenation |
US7085154B2 (en) * | 2003-06-03 | 2006-08-01 | Samsung Electronics Co., Ltd. | Device and method for pulse width control in a phase change memory device |
JP4820290B2 (ja) | 2004-05-13 | 2011-11-24 | 第一三共株式会社 | 置換ピロリジン誘導体 |
US7563805B2 (en) * | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
JP5063032B2 (ja) * | 2005-05-19 | 2012-10-31 | 第一三共株式会社 | トリ−、テトラ−置換−3−アミノピロリジン誘導体 |
EP1882685A4 (de) * | 2005-05-20 | 2010-10-27 | Daiichi Sankyo Co Ltd | Verfahren zur herstellung einer asymmetrischen, tetrasubstituierten kohlenstoffhaltigen verbindung |
US7977346B2 (en) | 2006-01-17 | 2011-07-12 | Guoqing Paul Chen | Spiro compounds and methods of use |
TWI386401B (zh) | 2006-03-27 | 2013-02-21 | Daiichi Seiyaku Co | 醫藥用水合物 |
SI2097400T1 (sl) | 2007-01-05 | 2013-10-30 | Daiichi Sankyo Company, Limited | Zliti substituirani aminopirolidinski derivat |
EP2311974B1 (de) | 2008-07-11 | 2012-12-19 | Sumitomo Chemical Company, Limited | Verfahren zur herstellung von (1s,2r)-2-chlor-2-fluorcyclopropancarbonsäure |
FR2961207B1 (fr) * | 2010-06-09 | 2013-01-18 | Oreal | Utilisation d'un derive de 4- carboxy 2-pyrrolidinone comme solvant dans les compositions cosmetiques ; compositions cosmetiques les contenant ; nouveaux composes |
CN103467448B (zh) * | 2013-09-18 | 2015-04-15 | 浙江司太立制药股份有限公司 | 7-(3-氨基-4-烷氧亚胺基-1-哌啶基)-1-[(1r,2s)-2-氟环丙基]喹诺酮羧酸类化合物及其制备方法 |
EP2957561A1 (de) * | 2014-06-18 | 2015-12-23 | Université Paris 6 Pierre et Marie Curie UPMC | Neuartige Fluorchinolone und ihre Verwendung zur Behandlung bakterieller Infektionen |
CN105330590B (zh) * | 2015-10-15 | 2018-09-25 | 广州市朗启医药科技有限责任公司 | 西他沙星五元环侧链中间体的制备方法 |
CN109912504B (zh) * | 2019-04-04 | 2020-11-10 | 山东省联合农药工业有限公司 | 一种喹啉羧酸类化合物及其制备方法与用途 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3576335D1 (de) * | 1984-12-14 | 1990-04-12 | Daiichi Seiyaku Co | Chinolincarbonsaeure-derivate. |
AU5427286A (en) * | 1985-03-08 | 1986-09-11 | Kyorin Pharmaceutical Co. Ltd. | 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives |
DE3509546A1 (de) * | 1985-03-16 | 1986-09-25 | Bayer Ag, 5090 Leverkusen | 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US4657913A (en) | 1985-04-18 | 1987-04-14 | Warner-Lambert Company | Trifluoro- quinoline -3- carboxylic acids and their use as anti-bacterial agents |
US4668680A (en) * | 1985-12-12 | 1987-05-26 | Warner-Lambert Company | 5-amino-6,8-difluoroquinolones as antibacterial agents |
US4735949A (en) | 1986-02-18 | 1988-04-05 | Warner-Lambert Company | Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents |
DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
DE3702393A1 (de) * | 1987-01-28 | 1988-08-11 | Bayer Ag | 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel |
US5290934A (en) * | 1987-04-16 | 1994-03-01 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
US4851418A (en) * | 1987-08-21 | 1989-07-25 | Warner-Lambert Company | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent |
IL90062A (en) * | 1988-04-27 | 1994-10-07 | Daiichi Seiyaku Co | History of pyridonecarboxylic acid, their preparation and pharmaceutical preparations containing them |
AU618823B2 (en) * | 1988-07-20 | 1992-01-09 | Sankyo Company Limited | 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use |
US5286723A (en) | 1988-08-31 | 1994-02-15 | Daiichi Seiyaku Co., Ltd. | Spiro compound |
FI901201A0 (fi) * | 1989-03-13 | 1990-03-09 | Bristol Myers Squibb Co | Antibakteriella 5-substituerade 1,4-dihydro-4-oxonaftyridin-3-karboxylatderivat och deras framstaellning. |
DE3910663A1 (de) * | 1989-04-03 | 1990-10-04 | Bayer Ag | 5-alkylchinoloncarbonsaeuren |
AR027761A1 (es) | 2000-03-31 | 2003-04-09 | Daiichi Seiyaku Co | Un derivado del acido quinolonacarboxilico, las composiciones antibacterianas que lo contienen y el uso de dicho derivado para la elaboracion de drogaspara el tratamiento de enfermedades infecciosas |
JP4820290B2 (ja) * | 2004-05-13 | 2011-11-24 | 第一三共株式会社 | 置換ピロリジン誘導体 |
-
1989
- 1989-04-24 IL IL9006289A patent/IL90062A/en unknown
- 1989-04-24 MY MYPI89000521A patent/MY105136A/en unknown
- 1989-04-25 NO NO891698A patent/NO175939C/no not_active IP Right Cessation
- 1989-04-26 PT PT90377A patent/PT90377B/pt not_active IP Right Cessation
- 1989-04-26 AU AU33702/89A patent/AU625414B2/en not_active Ceased
- 1989-04-26 JP JP1106762A patent/JP2714597B2/ja not_active Expired - Lifetime
- 1989-04-26 YU YU87589A patent/YU48432B/sh unknown
- 1989-04-26 UA UA5001894A patent/UA29378C2/uk unknown
- 1989-04-26 ES ES89107550T patent/ES2135372T3/es not_active Expired - Lifetime
- 1989-04-26 DE DE68929030T patent/DE68929030T2/de not_active Expired - Lifetime
- 1989-04-26 NZ NZ228893A patent/NZ228893A/xx unknown
- 1989-04-26 CA CA000597865A patent/CA1340801C/en not_active Expired - Fee Related
- 1989-04-26 EP EP89107550A patent/EP0341493B1/de not_active Expired - Lifetime
- 1989-04-26 FI FI891980A patent/FI96947C/fi not_active IP Right Cessation
- 1989-04-26 AT AT89107550T patent/ATE182145T1/de not_active IP Right Cessation
- 1989-04-26 SG SG1996006401A patent/SG48036A1/en unknown
- 1989-04-27 CN CN89103911A patent/CN1033751C/zh not_active Expired - Lifetime
- 1989-04-27 KR KR1019890005539A patent/KR0184614B1/ko not_active IP Right Cessation
- 1989-04-27 DK DK205789A patent/DK175467B1/da not_active IP Right Cessation
-
1991
- 1991-10-29 RU SU915001894A patent/RU2075475C1/ru not_active IP Right Cessation
-
1992
- 1992-12-30 LV LVP-92-696A patent/LV10092B/en unknown
-
1993
- 1993-10-28 US US08/142,105 patent/US5587386A/en not_active Ceased
-
1994
- 1994-02-28 BG BG98620A patent/BG61122B2/bg unknown
-
1995
- 1995-04-13 JP JP7088282A patent/JP2903292B2/ja not_active Expired - Lifetime
- 1995-06-07 US US08/477,886 patent/US5767127A/en not_active Expired - Lifetime
- 1995-06-22 HU HU95P/P00371P patent/HU211136A9/hu unknown
-
1997
- 1997-07-31 JP JP9205599A patent/JP2917010B2/ja not_active Expired - Fee Related
-
1998
- 1998-01-21 HK HK98100553A patent/HK1002108A1/xx not_active IP Right Cessation
- 1998-04-06 US US09/055,127 patent/US6031102A/en not_active Expired - Fee Related
- 1998-08-20 JP JP10233763A patent/JPH11124367A/ja active Pending
- 1998-08-20 JP JP10233764A patent/JPH11124380A/ja active Pending
-
1999
- 1999-09-29 GR GR990402459T patent/GR3031365T3/el unknown
-
2004
- 2004-06-03 US US10/859,587 patent/USRE41149E1/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |