DE69021564T2 - Enzyme und deren verwendung zum nachweis von drogen. - Google Patents

Enzyme und deren verwendung zum nachweis von drogen.

Info

Publication number
DE69021564T2
DE69021564T2 DE69021564T DE69021564T DE69021564T2 DE 69021564 T2 DE69021564 T2 DE 69021564T2 DE 69021564 T DE69021564 T DE 69021564T DE 69021564 T DE69021564 T DE 69021564T DE 69021564 T2 DE69021564 T2 DE 69021564T2
Authority
DE
Germany
Prior art keywords
enzyms
detecting drugs
drugs
detecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69021564T
Other languages
English (en)
Other versions
DE69021564D1 (de
Inventor
Neil Charles Bruce
Stephens Lauren Diana Gray
Christopher Robin Lowe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Macfarlan Smith Ltd
Original Assignee
British Technology Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Technology Group Ltd filed Critical British Technology Group Ltd
Publication of DE69021564D1 publication Critical patent/DE69021564D1/de
Application granted granted Critical
Publication of DE69021564T2 publication Critical patent/DE69021564T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/004—Enzyme electrodes mediator-assisted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69021564T 1989-05-12 1990-05-11 Enzyme und deren verwendung zum nachweis von drogen. Expired - Fee Related DE69021564T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898910958A GB8910958D0 (en) 1989-05-12 1989-05-12 Assay
PCT/GB1990/000727 WO1990013634A2 (en) 1989-05-12 1990-05-11 Enzymes and their use in drug detection

Publications (2)

Publication Number Publication Date
DE69021564D1 DE69021564D1 (de) 1995-09-14
DE69021564T2 true DE69021564T2 (de) 1996-01-18

Family

ID=10656644

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69021564T Expired - Fee Related DE69021564T2 (de) 1989-05-12 1990-05-11 Enzyme und deren verwendung zum nachweis von drogen.

Country Status (9)

Country Link
US (2) US5298414A (de)
EP (1) EP0471740B1 (de)
JP (1) JP3045540B2 (de)
AU (1) AU643687B2 (de)
CA (1) CA2055442C (de)
DE (1) DE69021564T2 (de)
GB (2) GB8910958D0 (de)
HU (1) HUT59959A (de)
WO (1) WO1990013634A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9115765D0 (en) * 1991-07-22 1991-09-04 Britt Adrian J Bacterial enzyme for cocaine detection
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
GB9213524D0 (en) * 1992-06-25 1992-08-12 Macfarlan Smith Ltd Biocatalysis in the synthesis of analgesic and antitussive compounds
GB9622516D0 (en) * 1996-10-29 1997-01-08 Univ Cambridge Tech Enzymic cofactor cycling
US6225074B1 (en) * 1997-08-18 2001-05-01 Dennis Wright Direct chloramphenicol acetyl transferase assay
ATE272836T1 (de) * 1999-03-19 2004-08-15 Sapporo Immuno Diagnostic Lab Verfahren zur bestimmung eines substrates, und biosensor
AU2000267324A1 (en) * 2000-08-28 2002-03-13 Sapporo Immuno Diagnostic Laboratory Method for determination of substrate and biosensor
WO2002022854A2 (en) * 2000-09-13 2002-03-21 Merck Patent Gmbh Method for the detection and measurement of biomass
EP1352050B1 (de) * 2001-01-09 2008-12-17 Lonza AG Mikrobiologisches verfahren zur herstellung von amiden
US8975063B2 (en) 2006-10-19 2015-03-10 California Institute Of Technology Compositions and methods for producing benzylisoquinoline alkaloids
CA2838797C (en) * 2011-07-27 2020-03-10 Agamatrix, Inc. Dry reagent comprising tetramethylammonium ferricyanide for electrochemical test strips
DK3553177T3 (da) 2013-03-15 2021-02-15 Univ Leland Stanford Junior Benzylisoquinolinalkaloider (bia) som producerer mikrober, og fremgangsmåder til fremstilling og anvendelse deraf
CA2965469A1 (en) 2013-11-04 2015-05-07 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
WO2015171839A1 (en) * 2014-05-08 2015-11-12 South Dakota Board Of Regents Chemical assay to verify the quantity and quality of sesquiterpene lactone derivatives
CA2983419A1 (en) 2015-05-04 2016-11-10 The Board Of Trustees Of The Leland Stanford Junior University Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same
AU2016261490B2 (en) 2015-05-08 2019-10-31 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
GB2579940B (en) 2017-08-03 2022-11-30 Antheia Inc Engineered benzylisoquinoline alkaloid epimerases and methods of producing benzylisoquinoline alkaloids

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH628009A5 (de) * 1977-07-26 1982-02-15 Hoffmann La Roche Verfahren zur herstellung von optisch aktiven alpha-hydroxycarbonsaeuren.
DK269987A (da) * 1986-06-03 1987-12-04 Hoffmann La Roche Enzym og fremgangsmaade til fremstilling deraf
US4876200A (en) * 1986-07-08 1989-10-24 Shell Oil Company New strains of pseudomonas putida

Also Published As

Publication number Publication date
CA2055442C (en) 1999-06-15
GB9010561D0 (en) 1990-07-04
EP0471740A1 (de) 1992-02-26
US5387515A (en) 1995-02-07
GB2231332B (en) 1993-04-21
JPH05504252A (ja) 1993-07-08
WO1990013634A3 (en) 1991-05-16
GB2231332A (en) 1990-11-14
EP0471740B1 (de) 1995-08-09
DE69021564D1 (de) 1995-09-14
HUT59959A (en) 1992-07-28
AU5647890A (en) 1990-11-29
CA2055442A1 (en) 1990-11-13
US5298414A (en) 1994-03-29
AU643687B2 (en) 1993-11-25
WO1990013634A2 (en) 1990-11-15
JP3045540B2 (ja) 2000-05-29
GB8910958D0 (en) 1989-06-28
HU904408D0 (en) 1992-01-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BTG INTERNATIONAL LTD., LONDON, GB

8327 Change in the person/name/address of the patent owner

Owner name: MACFARLAN SMITH LTD., EDINBURGH, SCHOTTLAND, GB

8339 Ceased/non-payment of the annual fee