DE69022254T2 - Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes. - Google Patents

Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes.

Info

Publication number
DE69022254T2
DE69022254T2 DE69022254T DE69022254T DE69022254T2 DE 69022254 T2 DE69022254 T2 DE 69022254T2 DE 69022254 T DE69022254 T DE 69022254T DE 69022254 T DE69022254 T DE 69022254T DE 69022254 T2 DE69022254 T2 DE 69022254T2
Authority
DE
Germany
Prior art keywords
ligand
receptor
analogue conjugate
target
fluid sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69022254T
Other languages
English (en)
Other versions
DE69022254D1 (de
Inventor
Kenneth Francis Buechler
Gunars E Valkirs
Richard Ray Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere San Diego Inc
Original Assignee
Biosite Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Diagnostics Inc filed Critical Biosite Diagnostics Inc
Publication of DE69022254D1 publication Critical patent/DE69022254D1/de
Application granted granted Critical
Publication of DE69022254T2 publication Critical patent/DE69022254T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/967—Standards, controls, materials, e.g. validation studies, buffer systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81—Tube, bottle, or dipstick
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/825—Pretreatment for removal of interfering factors from sample
DE69022254T 1989-01-10 1990-01-10 Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes. Expired - Lifetime DE69022254T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/295,568 US5028535A (en) 1989-01-10 1989-01-10 Threshold ligand-receptor assay

Publications (2)

Publication Number Publication Date
DE69022254D1 DE69022254D1 (de) 1995-10-19
DE69022254T2 true DE69022254T2 (de) 1996-02-15

Family

ID=23138252

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69022254T Expired - Lifetime DE69022254T2 (de) 1989-01-10 1990-01-10 Liganden-Rezeptor-Assays unter Verwendung eines Schwellenwertes.

Country Status (12)

Country Link
US (3) US5028535A (de)
EP (1) EP0378391B1 (de)
JP (1) JP2807565B2 (de)
AT (1) ATE127921T1 (de)
AU (1) AU633874B2 (de)
CA (1) CA2007532C (de)
DE (1) DE69022254T2 (de)
DK (1) DK0378391T3 (de)
ES (1) ES2079434T3 (de)
GR (1) GR3018366T3 (de)
PT (1) PT92828B (de)
WO (1) WO1990008319A1 (de)

Families Citing this family (312)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3842702A1 (de) * 1988-12-19 1990-06-21 Boehringer Mannheim Gmbh Testtraeger zur analytischen untersuchung einer probenfluessigkeit mit hilfe einer spezifischen bindungsreaktion zweier bioaffiner bindungspartner und entsprechendes testverfahren
US5939272A (en) * 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US6352863B1 (en) * 1990-01-19 2002-03-05 La Mina, Inc. Assay device
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
ES2089057T3 (es) * 1990-07-18 1996-10-01 Abbott Lab Un reactivo sustituto de un analito para uso en metodos de ensayo de fijacion especifica, dispositivos y kits.
US5143852A (en) * 1990-09-14 1992-09-01 Biosite Diagnostics, Inc. Antibodies to ligand analogues and their utility in ligand-receptor assays
JPH05504841A (ja) * 1990-09-14 1993-07-22 バイオサイト・ダイアグノスティックス・インコーポレイテッド リガンドレセプター及びリガンドのコンプレックスに対する抗体及びリガンド―レセプターアッセーでのそれらの用途
CA2056698A1 (en) * 1990-12-11 1992-06-12 John L. Palmer Assay, employing analog to digital signaling, for the presence of an analyte in a sample in conjunction with a binding component, apparatus for performing said process, and a method of performing said assay
DE69231382T2 (de) * 1991-04-12 2001-01-25 Biosite Diagnostics Inc Neue konjugate und testverfahren für die gleichzeitige bestimmung von multiplen liganden
US5998220A (en) 1991-05-29 1999-12-07 Beckman Coulter, Inc. Opposable-element assay devices, kits, and methods employing them
US6168956B1 (en) 1991-05-29 2001-01-02 Beckman Coulter, Inc. Multiple component chromatographic assay device
US5877028A (en) 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
EP0600936B1 (de) * 1991-07-29 1999-10-06 Serex, Inc. Differentielle bindungsaffinitäten und darauf beruhende dissoziationstestverfahren
US5451504A (en) * 1991-07-29 1995-09-19 Serex, Inc. Method and device for detecting the presence of analyte in a sample
AU2792292A (en) * 1991-10-09 1993-05-03 Hawaii Chemtect International Field kit for detecting analytes
US5623053A (en) * 1992-01-10 1997-04-22 California Institute Of Technology Soluble mammal-derived Fc receptor which binds at a pH ranging from about 5.5 to 6.5 and releases at a pH ranging from about 7.5 to 8.5
EP0643777A4 (de) * 1992-01-22 1995-06-07 Abbott Lab Kalibrierungsreagenzien für halbquantitative bindungsassays und vorrichtungen.
US5541069A (en) * 1992-02-28 1996-07-30 Quidel Corporation Assay having improved dose response curve
AU3972993A (en) * 1992-04-01 1993-11-08 Regents Of The University Of California, The Non-instrumented enzyme immunoassay: general method utilizing kinetic binding effects
US6767510B1 (en) * 1992-05-21 2004-07-27 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5458852A (en) * 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
US6905882B2 (en) * 1992-05-21 2005-06-14 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US7524456B1 (en) 1992-05-21 2009-04-28 Biosite Incorporated Diagnostic devices for the controlled movement of reagents without membranes
US6019944A (en) * 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
CA2096495C (en) * 1992-06-16 2002-07-09 Kathy Palmer Ordonez Dual analyte immunoassay
JP2859962B2 (ja) * 1992-09-28 1999-02-24 バイエックス インコーポレイティド 早産の予測方法
AU5676194A (en) * 1992-12-01 1994-06-22 Ensys, Inc. A petroleum immunoassay method, its components and a kit for use in performing the same
FI96143C (fi) * 1993-03-16 1996-05-10 Wallac Oy Biospesifinen määritysmenetelmä
US7322927B2 (en) 1993-09-24 2008-01-29 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US7083984B2 (en) 1993-09-24 2006-08-01 Biosite, Inc. Hybrid phthalocyanine derivatives and their uses
US5824799A (en) * 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US5527711A (en) * 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
US5589344A (en) * 1994-06-15 1996-12-31 Johnson & Johnson Clinical Diagnostics, Inc. Test kit and method for competitive specific binding assay
US6653066B1 (en) 1994-06-17 2003-11-25 Trinity Biotech Device and method for detecting polyvalent substances
WO1996003929A1 (en) * 1994-08-04 1996-02-15 Biex, Inc. Method for prediction of premature delivery using estetrol (e4) as an indicator
US5521102A (en) * 1994-08-08 1996-05-28 Quidel Corporation Controlled sensitivity immunochromatographic assay
US5710256A (en) * 1995-04-03 1998-01-20 Biosite Diagnostics Incorporated Methadone derivatives and protein and polypeptide methadone derivative conjugates and labels
JPH092926A (ja) * 1995-04-12 1997-01-07 Quest Internatl Bv 口内組成物
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5751629A (en) * 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5741462A (en) * 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US5567302A (en) * 1995-06-07 1996-10-22 Molecular Devices Corporation Electrochemical system for rapid detection of biochemical agents that catalyze a redox potential change
US7635597B2 (en) 1995-08-09 2009-12-22 Bayer Healthcare Llc Dry reagent particle assay and device having multiple test zones and method therefor
US6803040B1 (en) 1995-08-22 2004-10-12 Biosite, Inc. Derivatives of tricyclic antidepressants and protein and polypeptide tricyclic antidepressant derivative conjugates and labels
US5874216A (en) 1996-02-23 1999-02-23 Ensys Environmental Products, Inc. Indirect label assay device for detecting small molecules and method of use thereof
US7005132B2 (en) 1996-05-03 2006-02-28 Molecular Machines, Inc. Prodrug compositions and drug delivery methods using synthetic receptors
US5879951A (en) 1997-01-29 1999-03-09 Smithkline Diagnostics, Inc. Opposable-element assay device employing unidirectional flow
US20050101032A1 (en) * 1997-02-10 2005-05-12 Metrika, Inc. Assay device, composition, and method of optimizing assay sensitivity
US5939252A (en) 1997-05-09 1999-08-17 Lennon; Donald J. Detachable-element assay device
CA2290582C (en) 1997-05-14 2005-08-02 Kenneth F. Buechler Rapid evaluation of the ratio of biological molecules
GB2326712B (en) * 1997-06-25 2001-09-26 Fujirebio Kk Colour devoloping method,enzyme immunoassay using the colour developing method,and immunochromatography incorporating the enzyme immunoassay
US5985675A (en) 1997-12-31 1999-11-16 Charm Sciences, Inc. Test device for detection of an analyte
US6319466B1 (en) * 1997-07-16 2001-11-20 Charm Sciences, Inc. Test device for detecting the presence of a residue analyte in a sample
BE1012049A6 (fr) * 1998-06-25 2000-04-04 Ucb Bioproducts Procede pour la determination d'antibiotique a noyau beta-lactame dans un liquide biologique.
US6392894B1 (en) 1998-01-05 2002-05-21 Biosite Incorporated Media carrier for an assay device
US7713703B1 (en) 2000-11-13 2010-05-11 Biosite, Inc. Methods for monitoring the status of assays and immunoassays
US6830731B1 (en) * 1998-01-05 2004-12-14 Biosite, Inc. Immunoassay fluorometer
US6194222B1 (en) * 1998-01-05 2001-02-27 Biosite Diagnostics, Inc. Methods for monitoring the status of assays and immunoassays
US6284194B1 (en) 1998-03-11 2001-09-04 Albert E. Chu Analytical assay device and methods using surfactant treated membranes to increase assay sensitivity
AU2003200222B2 (en) * 1998-04-30 2006-02-02 Maiia Ab Ligand binding assay and kit with a separation zone for disturbing analytes
SE9801563D0 (sv) 1998-04-30 1998-04-30 Pharmacia & Upjohn Diag Ab Förfarande med separation och kit att användas vid förfarandet
US20060019404A1 (en) * 1998-05-06 2006-01-26 Blatt Joel M Quantitative assay with extended dynamic range
DE69836493T2 (de) 1998-07-22 2007-09-06 Syntron Bioresearch, Inc., Carlsbad Vorrichtung zur bestimmung von mehreren analyten
AU772324B2 (en) * 1998-10-16 2004-04-22 Ge Healthcare Bio-Sciences Ab Squaric acid activated carrier usable for immobilisation of compounds containingamine groups
CA2254223A1 (en) 1998-11-16 2000-05-16 Biophys, Inc. Device and method for analyzing a biologic sample
US7297554B2 (en) * 1998-11-18 2007-11-20 Microdiagnostics, Inc. Immunoassay system
US6136610A (en) * 1998-11-23 2000-10-24 Praxsys Biosystems, Inc. Method and apparatus for performing a lateral flow assay
US6528323B1 (en) * 1999-06-14 2003-03-04 Praxsys Biosystems, Inc. Bidirectional lateral flow test strip and method
US6727073B1 (en) 1999-11-19 2004-04-27 Binax, Inc. Method for detecting enteric disease
DE10009503A1 (de) * 2000-02-29 2001-08-30 Roche Diagnostics Gmbh Verfahren zur Immobilisierung von Konjugaten in diagnostischen Tests
WO2001066568A2 (en) * 2000-03-09 2001-09-13 Heska Corporation Use of recombinant antigens to determine the immune status of an animal
US6699722B2 (en) 2000-04-14 2004-03-02 A-Fem Medical Corporation Positive detection lateral-flow apparatus and method for small and large analytes
AU2001282035B2 (en) * 2000-08-03 2006-11-09 Inverness Medical Switzerland Gmbh Peptides capable of functioning as mimotopes for estradiol analytes
EP1947459A3 (de) * 2000-08-24 2008-09-24 Nanogen, Inc. Differential-Immunoassay
SE0003662D0 (sv) * 2000-10-11 2000-10-11 Pharmacia Diagnostics Ab Assay method and kit therefor
US6777198B2 (en) 2000-10-11 2004-08-17 Pharmacia Diagnostics Ab Assay method and kit therefor
WO2002051438A2 (en) 2000-12-22 2002-07-04 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Use of repulsive guidance molecule (rgm) and its modulators
US6770434B2 (en) 2000-12-29 2004-08-03 The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin Biological assay method
US6767710B2 (en) * 2001-03-30 2004-07-27 Praxsys Biosystems, Llc Prewetting stop flow test strip
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US7632647B2 (en) * 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US6833111B2 (en) 2001-04-13 2004-12-21 Varian, Inc. Multiple analyte assaying device with a multiple sample introduction system
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
EP2261669A1 (de) * 2001-05-04 2010-12-15 Alere San Diego, Inc. Diagnostischer Marker akuter Koronarsyndrome und Verfahren zu deren Verwendung
DE10125258A1 (de) * 2001-05-23 2003-01-09 November Ag Molekulare Medizin Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden
EP1417491A4 (de) * 2001-07-18 2004-08-11 Siliang Zhou Teststreifen für einen lateralfluss-assay für eine ganze zellen enthaltende probe
US7270959B2 (en) 2001-07-25 2007-09-18 Oakville Hong Kong Company Limited Specimen collection container
US7300633B2 (en) 2001-07-25 2007-11-27 Oakville Hong Kong Company Limited Specimen collection container
US20040219509A1 (en) * 2001-08-20 2004-11-04 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
CA2457775A1 (en) * 2001-08-20 2003-02-27 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
CA2459893C (en) * 2001-09-10 2014-01-21 Meso Scale Technologies, Llc Methods and apparatus for conducting multiple measurements on a sample
US7393696B2 (en) * 2001-09-28 2008-07-01 Aspenbio Pharma, Inc. Bovine pregnancy test
US8481334B1 (en) 2001-11-06 2013-07-09 Charm Sciences, Inc. Method of attaching a ligand to a solid support
CA2511372C (en) * 2002-12-26 2014-07-08 Jeff D. Debad Methods, compositions and kits for biomarker extraction
US7560272B2 (en) * 2003-01-04 2009-07-14 Inverness Medical Switzerland Gmbh Specimen collection and assay container
ES2535045T3 (es) 2003-04-10 2015-05-04 Vanderbilt Royalty Sub L.P. Usos y composiciones para administración de capsaicina
US7341838B2 (en) 2003-04-17 2008-03-11 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
CN100360938C (zh) * 2003-04-23 2008-01-09 北京科美东雅生物技术有限公司 甾体类激素-碱性磷酸酶结合物制备方法
US7517495B2 (en) 2003-08-25 2009-04-14 Inverness Medical Switzerland Gmbh Biological specimen collection and analysis system
EP1673465A4 (de) * 2003-09-29 2008-04-30 Biosite Inc Verfahren und zusammensetzungen zur sepsisdiagnose
US7410808B1 (en) * 2003-12-08 2008-08-12 Charm Sciences, Inc. Method and assay for detection of residues
US7150995B2 (en) * 2004-01-16 2006-12-19 Metrika, Inc. Methods and systems for point of care bodily fluid analysis
US20050227370A1 (en) * 2004-03-08 2005-10-13 Ramel Urs A Body fluid analyte meter & cartridge system for performing combined general chemical and specific binding assays
CN101031798B (zh) * 2004-07-29 2012-06-27 瑞莱诊断体系有限公司 侧向流系统和测定
US20060105419A1 (en) * 2004-08-16 2006-05-18 Biosite, Inc. Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions
WO2006031583A2 (en) * 2004-09-09 2006-03-23 Biosite Incorporated Methods and compositions for measuring canine bnp and uses thereof
US20060205012A1 (en) * 2004-12-09 2006-09-14 Meso Scale Technologies, Llc Diagnostic test
US20080050832A1 (en) * 2004-12-23 2008-02-28 Buechler Kenneth F Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
WO2006078813A2 (en) * 2005-01-21 2006-07-27 Biosite Incorporated Arginine analogs, and methods for their synthesis and use
US7396689B2 (en) * 2005-02-04 2008-07-08 Decision Biomarkers Incorporated Method of adjusting the working range of a multi-analyte assay
JP2008530139A (ja) * 2005-02-14 2008-08-07 ニューロジェシックス， インコーポレイテッド Ｔｒｐｖ１アゴニストを送達するための装置
US7939342B2 (en) 2005-03-30 2011-05-10 Kimberly-Clark Worldwide, Inc. Diagnostic test kits employing an internal calibration system
US20060222690A1 (en) * 2005-03-30 2006-10-05 Bley Keith R Low-concentration capsaicin patch and methods for treating neuropathic pain
WO2006128083A2 (en) 2005-05-25 2006-11-30 Curedm, Inc. Human proislet peptide, derivatives and analogs thereof, and methods of using same
WO2006132666A1 (en) * 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
US20070269836A1 (en) * 2005-06-09 2007-11-22 Mcpherson Paul H Methods and compositions for the diagnosis of venous thromboembolic disease
US20070218498A1 (en) * 2005-08-30 2007-09-20 Buechler Kenneth F Use of soluble FLT-1 and its fragments in cardiovascular conditions
US7829347B2 (en) * 2005-08-31 2010-11-09 Kimberly-Clark Worldwide, Inc. Diagnostic test kits with improved detection accuracy
CN101277974A (zh) 2005-09-30 2008-10-01 阿伯特有限及两合公司 排斥性引导分子(rgm)蛋白质家族的蛋白质的结合结构域及其功能性片段和它们的用途
US8492098B2 (en) 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
EP2005168A4 (de) * 2006-03-09 2009-05-20 Biosite Inc Verfahren und zusammensetzung zur diagnose von krankheiten der aorta
US8940527B2 (en) * 2006-03-31 2015-01-27 Lamina Equities Corp. Integrated device for analyte testing, confirmation, and donor identity verification
US11906512B2 (en) 2006-03-31 2024-02-20 Zeus Diagnostics, LLC Integrated device for analyte testing, confirmation, and donor identity verification
US7879623B2 (en) * 2006-03-31 2011-02-01 Guirguis Raouf A Integrated device for analyte, testing, confirmation, and donor identity verification
US7741103B2 (en) * 2006-03-31 2010-06-22 Guirguis Raouf A Integrated screening and confirmation device
US20080118924A1 (en) * 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
GB0611116D0 (en) 2006-06-06 2006-07-19 Oxford Genome Sciences Uk Ltd Proteins
EP2029745B1 (de) 2006-06-07 2011-10-12 Otago Innovation Limited Diagnoseverfahren und -marker
US20100311186A1 (en) * 2006-07-28 2010-12-09 Biosite Incorporated Devices and methods for performing receptor binding assays using magnetic particles
WO2008030122A1 (en) 2006-09-07 2008-03-13 University Of Otago Biomarkers
WO2008060607A2 (en) 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for monitoring and risk prediction in cardiorenal syndrome
WO2008061149A2 (en) * 2006-11-14 2008-05-22 Biosite Incorporated Methods and compositions for diagnosis and prognosis of renal artery stenosis
US20080112847A1 (en) * 2006-11-15 2008-05-15 Nancy Yu Chen Collecting and testing device and method of use
TW200826088A (en) * 2006-12-08 2008-06-16 Lite On It Corp Optical disk drive with defocus-prohibited device
EP1933140B1 (de) * 2006-12-11 2011-08-17 AraGen Biotechnology Co. Ltd. Verfahren zur Detektion von Antikörpern mittels eines durch Oligonukleotide verstärkten kolloidalen Gold Signals
CN101021526B (zh) 2007-03-16 2012-01-25 艾博生物医药(杭州)有限公司 一种直观显示检测结果的装置和方法
US20090004755A1 (en) * 2007-03-23 2009-01-01 Biosite, Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US8221995B2 (en) * 2007-03-23 2012-07-17 Seok-Won Lee Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
US20110195852A1 (en) 2007-08-30 2011-08-11 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution
EP2193142B1 (de) 2007-08-30 2015-01-07 CureDM Group Holdings, LLC Zusammensetzungen und verfahren zur anwendung von proinselzellpeptiden und analoga davon
JP2010538108A (ja) * 2007-08-31 2010-12-09 コーニング インコーポレイテッド 高分子基板の反応表面
US20110082080A1 (en) * 2007-10-12 2011-04-07 Curedm Group Holdings, Llc Compositions and methods of using the human proislet peptide receptor
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
JP5818440B2 (ja) 2008-03-12 2015-11-18 オタゴ イノベーション リミテッド バイオマーカー
JP2011516038A (ja) 2008-03-12 2011-05-26 オタゴ イノベーション リミテッド バイオマーカー
CN105067819B (zh) 2008-08-28 2018-05-22 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
EP2813848A3 (de) 2008-08-29 2015-03-11 Astute Medical, Inc. Verfahren und Zusammensetzungen zur Diagnose und Prognose von Nierenläsion und Niereninsuffizienz
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
CA2740923A1 (en) 2008-10-21 2010-04-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2009308497B2 (en) 2008-10-21 2014-10-23 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2361018B1 (de) 2008-11-10 2015-04-01 Astute Medical, Inc. Verfahren und zusammensetzungen für die diagnose und prognose von nierenschädigung und nierenversagen
CN102272328B (zh) 2008-11-22 2014-06-18 阿斯图特医药公司 用于诊断和预后肾损伤和肾衰竭的方法和组合物
EP2194381B1 (de) 2008-12-03 2015-12-02 Roche Diagnostics GmbH Testelement mit kombinierter Kontroll- und Kalibrationszone
WO2010065944A1 (en) * 2008-12-05 2010-06-10 Serametrix Autoantibody detection systems and methods
US9234889B1 (en) 2008-12-18 2016-01-12 Charm Sciences, Inc. Method and test strip for detecting residues
CN102597258B (zh) 2009-02-06 2016-02-17 阿斯图特医药公司 肾损伤和肾衰竭的诊断及预后
AU2010279249B2 (en) 2009-02-06 2015-08-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
NZ601575A (en) 2009-02-06 2014-08-29 Astute Medical Inc Methods and compositions for diagnosis and prognosis of renal injury and failure
BRPI1006595A2 (pt) * 2009-04-15 2017-09-26 Relia Diagnostic Systems Inc tira de teste e método para detectar a presença de um análito em uma amostra
WO2011001337A1 (en) * 2009-06-30 2011-01-06 Koninklijke Philips Electronics N. V. Magnetic sensor device, method of operating such a device and sample
WO2011006119A2 (en) 2009-07-09 2011-01-13 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
CA2770382A1 (en) 2009-08-07 2011-02-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP5775874B2 (ja) 2009-08-28 2015-09-09 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
CA2773905A1 (en) 2009-09-18 2011-03-24 Astute Medical, Inc. Methods and composition for diagnosis and prognosis of renal injury and renal failure
WO2011035323A1 (en) 2009-09-21 2011-03-24 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
AU2010314999B2 (en) 2009-11-07 2014-06-26 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP2013510322A (ja) 2009-11-07 2013-03-21 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後診断のための方法ならびに組成物
CN102656190A (zh) 2009-12-08 2012-09-05 雅培股份有限两合公司 用于在视网膜神经纤维层变性治疗中使用的针对rgm a蛋白质的单克隆抗体
KR20120123056A (ko) 2009-12-20 2012-11-07 아스튜트 메디컬 인코포레이티드 신손상 및 신부전을 진단 및 예측하는 방법 및 조성물
US11275084B2 (en) 2010-01-15 2022-03-15 Stanford University Successive sampling device and associated method
CN105158481A (zh) 2010-02-05 2015-12-16 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
CA2788829A1 (en) 2010-02-05 2011-08-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CA2789147A1 (en) 2010-02-05 2011-08-11 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2011106746A1 (en) 2010-02-26 2011-09-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
JP5363663B2 (ja) 2010-03-01 2013-12-11 クワンテリクス コーポレーション 分子または粒子を検出するアッセイにおけるダイナミックレンジを拡張するための方法またはシステム
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) * 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
ES2945032T3 (es) 2010-05-06 2023-06-28 Charm Sciences Inc Dispositivo de incubadora con lector
EP3489688A1 (de) 2010-06-23 2019-05-29 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
WO2011162821A1 (en) 2010-06-23 2011-12-29 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3339859A1 (de) 2010-06-23 2018-06-27 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
EP3246335A3 (de) 2010-07-19 2017-12-27 Otago Innovation Limited Signalbiomarker
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
CN103189394B (zh) 2010-09-24 2016-08-17 阿斯图特医药公司 利用透明质酸评价肾损伤的方法和组合物
US10557856B2 (en) 2010-09-24 2020-02-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Biomarkers of renal injury
CA2811438A1 (en) 2010-10-07 2012-04-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP2646822B1 (de) 2010-11-29 2017-11-01 Alere San Diego, Inc. Verfahren zur diagnose und risikovorhersage bei herzversagen
CN102121901B (zh) * 2010-11-30 2012-07-04 南通市伊士生物技术有限责任公司 一种金标试条半定量快速检测电子笔装置的检测方法
CN102095851A (zh) * 2010-11-30 2011-06-15 南通市伊士生物技术有限责任公司 金标试条半定量快速检测电子笔装置的检测方法
JP6056138B2 (ja) * 2010-12-28 2017-01-11 東ソー株式会社 免疫学的測定方法
CA2824434A1 (en) 2011-01-08 2012-07-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
US9551720B2 (en) 2011-01-26 2017-01-24 University of Pittsburgh—Of the Commonwaelth System of Higher Education Urine biomarkers for prediction of recovery after acute kidney injury: proteomics
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
EP2668499A4 (de) 2011-01-29 2015-05-27 Astute Medical Inc Verfahren und zusammensetzungen zur diagnose und prognose von nierenverletzungen und niereninsuffizienz
WO2012129650A1 (en) * 2011-03-25 2012-10-04 Nanospeed Diagnostics Inc. Lateral flow immunoassay for detecting vitamins
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
MX346096B (es) 2011-08-26 2017-03-07 Astute Medical Inc Métodos y composiciones para diagnóstico y pronóstico de lesión renal e insuficiencia renal.
CA2856399A1 (en) 2011-11-22 2013-05-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2013086359A1 (en) 2011-12-08 2013-06-13 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
CN104136462B (zh) 2011-12-14 2017-06-09 艾伯维德国有限责任两合公司 用于诊断和治疗铁相关病症的组合物和方法
CN104144947B (zh) 2011-12-14 2017-10-27 艾伯维德国有限责任两合公司 用于诊断和治疗铁相关病症的组合物和方法
SG10202006762PA (en) 2012-01-27 2020-08-28 Abbvie Deutschland Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
CA2865563A1 (en) 2012-02-27 2013-09-06 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
KR20140147837A (ko) 2012-03-13 2014-12-30 애브비 인코포레이티드 Ｖ1ｂ 길항제 치료요법을 위한 대상체를 선택하거나 선별하는 방법
IN2014DN08537A (de) 2012-03-20 2015-05-15 Otago Innovation Ltd
WO2013152047A1 (en) 2012-04-02 2013-10-10 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
EP2836831B1 (de) 2012-04-11 2017-10-11 Alere San Diego, Inc. Mikrofluidisches immunoassay verfahren
CN104364652A (zh) * 2012-04-20 2015-02-18 Zbx公司 用于检测样品中的分析物的固相载体和方法
WO2013163345A1 (en) 2012-04-24 2013-10-31 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of stroke or other cerebral injury
DE102012013888A1 (de) 2012-07-09 2014-05-22 Schebo Biotech Ag Testkit (Kombi-Schnelltest) zum synchronen Nachweis von Biomarkern im Stuhl zur Erkennung pathologischer Veränderungen im Gastrointestinaltrakt, insbesondere im Darm
DE202012012084U1 (de) 2012-07-09 2013-04-15 Schebo Biotech Ag Testkit (Kombi-Schnelltest) zum synchronen Nachweis von Biomarkern im Stuhl zur Erkennung pathologischer Veränderungen im Gastrointestinaltrakt, insbesondere im Darm
WO2014018464A1 (en) 2012-07-23 2014-01-30 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of sepsis
US20150241415A1 (en) 2012-08-11 2015-08-27 Astute Medical, Inc. Evaluating renal injury using hyaluronic acid
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
TR201807542T4 (tr) 2013-01-17 2018-06-21 Astute Medical Inc Böbrek hasarı ve böbrek yetmezliği teşhisi ve prognozuna yönelik metotlar ve bileşimler.
US9694069B2 (en) 2013-03-14 2017-07-04 Alere San Diego, Inc. 6-acetylmorphine analogs, and methods for their synthesis and use
WO2014152656A1 (en) 2013-03-14 2014-09-25 Cheng Kasing Test strip housing system
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
CN105556305A (zh) 2013-06-05 2016-05-04 阿斯图特医药公司 用于肾损伤和肾衰竭的诊断及预后的方法和组合物
EP3003372B1 (de) 2013-06-07 2019-10-09 Duke University Inhibitoren des komplementfaktors h
WO2015021308A1 (en) 2013-08-07 2015-02-12 Astute Medical, Inc. Assays for timp2 having improved performance in biological samples
KR102322057B1 (ko) 2013-08-23 2021-11-05 리아타 파마슈티컬즈, 아이엔씨. 바독솔론 메틸 또는 이의 유사체를 이용한 내피 기능장애의 치료 및 예방 방법
WO2015031626A1 (en) 2013-08-28 2015-03-05 Abbvie Inc. Soluble cmet assay
EP3047270A4 (de) 2013-09-20 2017-07-19 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von appendizitis und differenzierung von ursachen für bauchschmerzen
CA3185700A1 (en) 2013-11-06 2015-05-14 Astute Medical, Inc. Assays for igfbp7 having improved performance in biological samples
JP2016540759A (ja) 2013-12-03 2016-12-28 アスチュート メディカル，インコーポレイテッド 腎損傷および腎不全の診断および予後のための方法および組成物
AU2014373792A1 (en) 2013-12-30 2016-07-07 Genomatix Genomic rearrangements associated with prostate cancer and methods of using the same
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3825416A3 (de) 2014-05-22 2021-09-15 The Scripps Research Institute Mit subklinischer nierentransplantatabstossung assoziierte genexpressionsprofile
EP3146455A4 (de) 2014-05-22 2018-05-02 The Scripps Research Institute Molekulare signaturen zur unterscheidung von lebertransplantatabstossungen oder -verletzungen
EP3146077A4 (de) 2014-05-22 2018-05-02 The Scripps Research Institute Molekulare gewebesignaturen von nierentransplantatabstossungen
ES2907551T3 (es) 2014-10-20 2022-04-25 Astute Medical Inc Procedimientos y composiciones para el diagnóstico y pronóstico de una lesión renal y una insuficiencia renal
WO2016090244A2 (en) 2014-12-05 2016-06-09 Mbio Diagnostics, Inc. Methods and devices for performing high dynamic range immunoassays
ES2943579T3 (es) 2014-12-18 2023-06-14 Astute Medical Inc Procedimientos y composiciones para el diagnóstico y pronóstico de lesión renal e insuficiencia renal
US11243202B2 (en) 2015-04-09 2022-02-08 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
EP3294416A4 (de) 2015-05-12 2018-11-21 Astute Medical, Inc. Verfahren und zusammensetzungen zur diagnose und prognose von nierenläsion und niereninsuffizienz
AU2016275071A1 (en) 2015-06-11 2018-02-01 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of renal injury and renal failure
WO2016205740A1 (en) 2015-06-17 2016-12-22 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
JP2018523469A (ja) 2015-07-10 2018-08-23 ウエストバージニア ユニバーシティＷｅｓｔ Ｖｉｒｇｉｎｉａ Ｕｎｉｖｅｒｓｉｔｙ 脳卒中および脳卒中重篤度のマーカー
EP3362180B1 (de) 2015-10-15 2020-06-17 Inbios International Inc. Multiplex-lateral-fluss-assay-systeme und verfahren zu deren verwendung
EP3420364A4 (de) * 2016-02-24 2019-10-09 Emanuel Smeds Verfahren zur verwendung von biologischem material zur bestimmung der unterschiede in der bindung an ein moleküle von interesse
CA3024622A1 (en) 2016-05-18 2017-11-23 Alere San Diego, Inc. 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use
US11243217B2 (en) 2016-06-06 2022-02-08 Astute Medical, Inc. Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
JP2019530875A (ja) 2016-10-03 2019-10-24 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 患者サンプルにおけるｕｃｈ−ｌ１状況を評価する改善された方法
US11633411B2 (en) 2016-10-04 2023-04-25 University Of Maryland, Baltimore Methods of treating sepsis using anti-sepsis lipid A (ASLA) based therapeutics
MA46749A (fr) 2016-11-08 2019-09-18 Reata Pharmaceuticals Inc Méthodes de traitement du syndrome d'alport à l'aide d'un méthyle de bardoxolone ou d'analogues de ce dernier
JP6795951B2 (ja) * 2016-11-09 2020-12-02 旭化成株式会社 濃度推定方法、検出装置、処理装置、プログラムおよび検出システム
MX2019008260A (es) 2017-01-12 2020-01-27 Astute Medical Inc Metodos y composiciones para la evaluacion y tratamiento de lesion renal e insuficiencia renal con base en la medicion del ligando 14 de quimiocina de la porcion c-c.
US10564155B2 (en) 2017-01-27 2020-02-18 Raouf A Guirguis Dual swab fluid sample collection for split sample testing and fingerprint identification device
EP3593134A1 (de) 2017-03-09 2020-01-15 Cleara Biotech B.V. Biomarker für zellalterung
WO2018175942A1 (en) 2017-03-23 2018-09-27 Abbott Laboratories Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1
CN110546513A (zh) 2017-04-15 2019-12-06 雅培实验室 使用早期生物标记物帮助超急性诊断和确定人类受试者中的创伤性脑损伤的方法
EP3635407A1 (de) 2017-04-28 2020-04-15 Abbott Laboratories Verfahren zur unterstützung der hyperakuten diagnose und bestimmung von traumatischer hirnverletzung unter verwendung von frühbiomarkern auf mindestens zwei proben aus dem gleichen menschlichen patienten
US10865238B1 (en) 2017-05-05 2020-12-15 Duke University Complement factor H antibodies
US20210025875A1 (en) 2017-05-07 2021-01-28 Astute Medical, Inc. Use of insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 in the management of renal replacement therapy
CN110651190A (zh) 2017-05-25 2020-01-03 雅培实验室 用早期生物标记物帮助确定是否对已遭受或可能已遭受头部损伤的人受试者执行成像的方法
AU2018275235A1 (en) 2017-05-30 2019-10-31 Abbott Laboratories Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin I and early biomarkers
WO2019010131A1 (en) 2017-07-03 2019-01-10 Abbott Laboratories IMPROVED METHODS FOR MEASURING CARBOXY TERMINATION HYDROLASE LEVELS OF UBIQUITIN L1 IN BLOOD
CN111094983A (zh) 2017-12-09 2020-05-01 雅培实验室 使用胶质细胞原纤维酸性蛋白(gfap)和/或泛素羧基末端水解酶l1(uch-l1)帮助诊断和评价已遭受骨科损伤并已遭受或可能已遭受头部损伤诸如轻度创伤性脑损伤(tbi)的患者的方法
EP3721234A1 (de) 2017-12-09 2020-10-14 Abbott Laboratories Verfahren zur unterstützung bei der diagnose und bewertung einer traumatischen hirnverletzung beim menschen mit einer kombination aus gfap und uch-l1
CN112041341A (zh) 2017-12-28 2020-12-04 机敏医药股份有限公司 Ccl14的抗体和检测
JP7437303B2 (ja) 2017-12-29 2024-02-22 アボット・ラボラトリーズ 外傷性脳損傷を診断及び査定するための、新規のバイオマーカー及び方法
US20210239700A1 (en) 2018-05-04 2021-08-05 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
US20210205264A1 (en) 2018-09-04 2021-07-08 H. Lee Moffitt Cancer Center & Research Institute Inc. Use of delta-tocotrienol for treating cancer
CN113454455A (zh) 2018-12-28 2021-09-28 雅培制药有限公司 微粒上的单分子的直接检测
WO2020144535A1 (en) 2019-01-08 2020-07-16 Aduro Biotech Holdings, Europe B.V. Methods and compositions for treatment of multiple myeloma
EP3931573A1 (de) 2019-03-01 2022-01-05 Abbott Laboratories Verfahren zur vorhersage von schwerwiegenden kardiovaskulären ereignissen bei patienten mit koronararterienerkrankung
WO2020180645A1 (en) 2019-03-01 2020-09-10 Meso Scale Technologies, Llc. Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
EP4136459A1 (de) 2020-04-13 2023-02-22 Abbott Laboratories Verfahren, komplexe und kits zum nachweis oder zur bestimmung einer menge eines ss-coronavirus-antikörpers in einer probe
WO2021222827A1 (en) 2020-05-01 2021-11-04 Meso Scale Technologies, Llc. Methods and kits for virus detection
CA3177913A1 (en) 2020-05-09 2021-11-18 Deborah FERGUSON Methods of treating covid-19 using bardoxolone methyl or analogs thereof
MX2022015287A (es) 2020-06-01 2023-02-22 Loop Diagnostics S L Metodo y kit para la deteccion temprana de septicemia.
WO2022031804A1 (en) 2020-08-04 2022-02-10 Abbott Laboratories Improved methods and kits for detecting sars-cov-2 protein in a sample
KR20230084469A (ko) 2020-08-04 2023-06-13 애보트 라피드 다이어그노스틱스 인터내셔널 언리미티드 컴퍼니 Sars-cov-2를 검출하기 위한 검정법
WO2023102384A1 (en) 2021-11-30 2023-06-08 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a subject having received a head computerized tomography scan that is negative for a tbi
US20220170948A1 (en) 2020-12-01 2022-06-02 Abbott Laboratories Use of one or more biomarkers to determine traumatic brain injury (tbi) in a human subject having received a head computerized tomography scan that is negative for a tbi
WO2022126129A1 (en) 2020-12-11 2022-06-16 Reata Pharmaceuticals, Inc. Synthetic triterpenoids for use in therapy
WO2022147147A1 (en) 2020-12-30 2022-07-07 Abbott Laboratories Methods for determining sars-cov-2 antigen and anti-sars-cov-2 antibody in a sample
AU2022279156A1 (en) 2021-05-18 2023-11-02 Abbott Laboratories Methods of evaluating brain injury in a pediatric subject
US20220381780A1 (en) 2021-05-21 2022-12-01 Meso Scale Technologies, Llc. Viral strain serology assays
AU2022293389A1 (en) 2021-06-14 2024-01-04 Abbott Laboratories Methods of diagnosing or aiding in diagnosis of brain injury caused by acoustic energy, electromagnetic energy, an over pressurization wave, and/or blast wind
WO2023278293A1 (en) 2021-06-28 2023-01-05 Meso Scale Technologies, Llc. Methods, compositions, and kits for assay signal amplification
WO2023028186A1 (en) 2021-08-27 2023-03-02 Abbott Laboratories Methods for detecting immunoglobulin g, subclass 4 (igg4) in a biological sample
WO2023034777A1 (en) 2021-08-31 2023-03-09 Abbott Laboratories Methods and systems of diagnosing brain injury
WO2023056268A1 (en) 2021-09-30 2023-04-06 Abbott Laboratories Methods and systems of diagnosing brain injury
WO2023114978A1 (en) 2021-12-17 2023-06-22 Abbott Laboratories Systems and methods for determining uch-l1, gfap, and other biomarkers in blood samples
WO2023129942A1 (en) 2021-12-28 2023-07-06 Abbott Laboratories Use of biomarkers to determine sub-acute traumatic brain injury (tbi) in a subject having received a head computerized tomography (ct) scan that is negative for a tbi or no head ct scan
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023150652A1 (en) 2022-02-04 2023-08-10 Abbott Laboratories Lateral flow methods, assays, and devices for detecting the presence or measuring the amount of ubiquitin carboxy-terminal hydrolase l1 and/or glial fibrillary acidic protein in a sample
WO2023212293A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Complement factor h related 4-specific antibodies and uses thereof
WO2023212294A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Angiopoietin-related protein 7-specific antibodies and uses thereof
WO2023212298A1 (en) 2022-04-29 2023-11-02 Broadwing Bio Llc Bispecific antibodies and methods of treating ocular disease
WO2023245184A1 (en) 2022-06-17 2023-12-21 Meso Scale Technologies, Llc. Viral strain serology assays
WO2024059708A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Biomarkers and methods for differentiating between mild and supermild traumatic brain injury
WO2024059692A1 (en) 2022-09-15 2024-03-21 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
WO2024064904A1 (en) 2022-09-23 2024-03-28 Meso Scale Technologies, Llc. Orthopoxvirus serology assays

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654090A (en) * 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US4203802A (en) * 1971-05-14 1980-05-20 Syva Company Inhibitable enzyme amplification assay
US3884898A (en) * 1972-08-18 1975-05-20 Syva Co Normorphine derivatives bonded to proteins
US3878187A (en) * 1972-09-11 1975-04-15 Syva Co Polypeptide derivatives of amphetamine and analogs for immunoassays
SE388694B (sv) * 1975-01-27 1976-10-11 Kabi Ab Sett att pavisa ett antigen exv i prov av kroppvetskor, med utnyttjande av till porost berarmaterial bundna eller adsorberande antikroppar
JPS51114985A (en) * 1975-04-01 1976-10-09 Kyoto Daiichi Kagaku:Kk Mothod to analyse urine, etc.
US4120945A (en) * 1976-07-06 1978-10-17 Becton, Dickinson & Company Substrate coated with receptor and labeled ligand for assays
US4200690A (en) * 1976-12-16 1980-04-29 Millipore Corporation Immunoassay with membrane immobilized antibody
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4791055A (en) * 1978-04-10 1988-12-13 Miles Inc. Homogenous specific binding assay reagent system and labeled conjugates
JPS5510590A (en) * 1978-05-04 1980-01-25 Wellcome Found Enzyme immunity quantity analysis
NL7807532A (nl) * 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4246339A (en) * 1978-11-01 1981-01-20 Millipore Corporation Test device
US4281065A (en) * 1979-01-25 1981-07-28 Syva Company Phencyclidine conjugates to antigenic proteins and enzymes
US4533629A (en) * 1981-04-17 1985-08-06 Syva Company Simultaneous calibration heterogeneous immunoassay
US4299916A (en) * 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4391904A (en) * 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4540659A (en) * 1981-04-17 1985-09-10 Syva Company Simultaneous calibration heterogeneous immunoassay
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
US4425438A (en) * 1981-03-13 1984-01-10 Bauman David S Assay method and device
US4446232A (en) * 1981-10-13 1984-05-01 Liotta Lance A Enzyme immunoassay with two-zoned device having bound antigens
JPH0616046B2 (ja) * 1982-03-19 1994-03-02 エキンズ，ロジャー フィリップ 遊離リガンドアッセイ方法およびキット
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
US4435504A (en) * 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
US4477576A (en) * 1982-07-26 1984-10-16 Mex Research Associates Antigen assay method and kit
EP0114614A2 (de) * 1983-01-25 1984-08-01 Abbott Laboratories Bestimmung von Steroidhormon-Glucuroniden
US4496654A (en) * 1983-04-08 1985-01-29 Quidel Detection of HCG with solid phase support having avidin coating
GB8331514D0 (en) * 1983-11-25 1984-01-04 Janssen Pharmaceutica Nv Visualization method
US4703017C1 (en) * 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
GB2161165A (en) * 1984-06-12 1986-01-08 Cambridge Patent Dev Secondary antibodies
AU560779B2 (en) * 1985-01-24 1987-04-16 Quidel Assay for drugs of abuse
US4740468A (en) * 1985-02-14 1988-04-26 Syntex (U.S.A.) Inc. Concentrating immunochemical test device and method
GB2171999A (en) * 1985-03-04 1986-09-10 Iq Antibodies
CA1272127A (en) * 1985-04-04 1990-07-31 Hybritech Incorporated Solid phase system for use in ligand-receptor assays
JPS62502495A (ja) * 1985-04-10 1987-09-24 イムニコン・コ−ポレ−ション 直接均質検定
US4743542A (en) * 1985-04-11 1988-05-10 Ortho Diagnostic Method for forestalling the hook effect in a multi-ligand immunoassay system
US4803170A (en) * 1985-05-09 1989-02-07 Ultra Diagnostics Corporation Competitive immunoassay method, device and test kit
US4746631A (en) * 1985-05-09 1988-05-24 Ultra Diagnostics Corporation Immunoassay method, device, and test kit
JPS62231168A (ja) * 1986-03-21 1987-10-09 ハイブリテツク・インコ−ポレイテツド アナライト−レセプタ−分析用内部標準を設けるための改良法
US4778751A (en) * 1986-05-12 1988-10-18 Diagnostic Products Corporation Method for measuring antigens or antibodies in biological fluids using ligand labeled antigens or ligand labeled antibodies
US5030558A (en) * 1986-11-07 1991-07-09 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
EP0271204A3 (de) * 1986-11-07 1989-10-25 Syntex (U.S.A.) Inc. Immunochromatographische Methode und Vorrichtung
US4817837A (en) * 1987-09-03 1989-04-04 Grover Betty L Strap for holding skis and ski poles
US4952517A (en) * 1988-02-08 1990-08-28 Hygeia Sciences, Inc. Positive step immunoassay

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CA2007532A1 (en) 1990-07-10
GR3018366T3 (en) 1996-03-31
AU633874B2 (en) 1993-02-11
DK0378391T3 (da) 1996-01-02
PT92828B (pt) 1996-04-30
EP0378391B1 (de) 1995-09-13
JP2807565B2 (ja) 1998-10-08
US5089391A (en) 1992-02-18
WO1990008319A1 (en) 1990-07-26
PT92828A (pt) 1991-09-13
EP0378391A2 (de) 1990-07-18
AU5021590A (en) 1990-08-13
US5028535A (en) 1991-07-02
DE69022254D1 (de) 1995-10-19
ATE127921T1 (de) 1995-09-15
ES2079434T3 (es) 1996-01-16
JPH03503215A (ja) 1991-07-18
US5679526A (en) 1997-10-21
EP0378391A3 (de) 1991-10-02

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