DE69028011T2 - Verlängerte Wirkstoffabgabe von kleinen, wasserlöslichen Molekülen - Google Patents

Verlängerte Wirkstoffabgabe von kleinen, wasserlöslichen Molekülen

Info

Publication number
DE69028011T2
DE69028011T2 DE69028011T DE69028011T DE69028011T2 DE 69028011 T2 DE69028011 T2 DE 69028011T2 DE 69028011 T DE69028011 T DE 69028011T DE 69028011 T DE69028011 T DE 69028011T DE 69028011 T2 DE69028011 T2 DE 69028011T2
Authority
DE
Germany
Prior art keywords
fluid
biologically active
water
polymeric matrix
molecules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69028011T
Other languages
English (en)
Other versions
DE69028011D1 (de
Inventor
Bernhard A Dr Sabel
Andrew Freese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of DE69028011D1 publication Critical patent/DE69028011D1/de
Application granted granted Critical
Publication of DE69028011T2 publication Critical patent/DE69028011T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
DE69028011T 1989-09-14 1990-08-31 Verlängerte Wirkstoffabgabe von kleinen, wasserlöslichen Molekülen Expired - Lifetime DE69028011T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/407,418 US5114719A (en) 1987-04-29 1989-09-14 Extended drug delivery of small, water-soluble molecules

Publications (2)

Publication Number Publication Date
DE69028011D1 DE69028011D1 (de) 1996-09-12
DE69028011T2 true DE69028011T2 (de) 1997-01-23

Family

ID=23612002

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69028011T Expired - Lifetime DE69028011T2 (de) 1989-09-14 1990-08-31 Verlängerte Wirkstoffabgabe von kleinen, wasserlöslichen Molekülen

Country Status (6)

Country Link
US (1) US5114719A (de)
EP (1) EP0417572B1 (de)
AT (1) ATE141047T1 (de)
DE (1) DE69028011T2 (de)
DK (1) DK0417572T3 (de)
ES (1) ES2093625T3 (de)

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Also Published As

Publication number Publication date
EP0417572A3 (en) 1991-06-12
US5114719A (en) 1992-05-19
ATE141047T1 (de) 1996-08-15
DE69028011D1 (de) 1996-09-12
EP0417572B1 (de) 1996-08-07
EP0417572A2 (de) 1991-03-20
DK0417572T3 (da) 1996-09-02
ES2093625T3 (es) 1997-01-01

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