DE69029269D1 - Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze - Google Patents

Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze

Info

Publication number
DE69029269D1
DE69029269D1 DE69029269T DE69029269T DE69029269D1 DE 69029269 D1 DE69029269 D1 DE 69029269D1 DE 69029269 T DE69029269 T DE 69029269T DE 69029269 T DE69029269 T DE 69029269T DE 69029269 D1 DE69029269 D1 DE 69029269D1
Authority
DE
Germany
Prior art keywords
procedures
hydrolytic
substrates
enzyms
new inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69029269T
Other languages
English (en)
Other versions
DE69029269T2 (de
Inventor
Edward Dennis
William Washburn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
University of California Berkeley
Original Assignee
University of California
University of California Berkeley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23581012&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69029269(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of California, University of California Berkeley filed Critical University of California
Publication of DE69029269D1 publication Critical patent/DE69029269D1/de
Application granted granted Critical
Publication of DE69029269T2 publication Critical patent/DE69029269T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/10—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases p-Nitrophenol derivatives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69029269T 1989-08-29 1990-08-17 Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze Expired - Fee Related DE69029269T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39979989A 1989-08-29 1989-08-29
PCT/US1990/004641 WO1991003544A1 (en) 1989-08-29 1990-08-17 Novel hydrolytic enzyme inhibitors and substrates and assays, methods and kits embodying same

Publications (2)

Publication Number Publication Date
DE69029269D1 true DE69029269D1 (de) 1997-01-09
DE69029269T2 DE69029269T2 (de) 1997-05-28

Family

ID=23581012

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69029269T Expired - Fee Related DE69029269T2 (de) 1989-08-29 1990-08-17 Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze

Country Status (8)

Country Link
US (2) US5427919A (de)
EP (1) EP0489839B1 (de)
JP (1) JP3100057B2 (de)
AT (1) ATE145672T1 (de)
AU (1) AU643952B2 (de)
CA (1) CA2064793C (de)
DE (1) DE69029269T2 (de)
WO (1) WO1991003544A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69029269T2 (de) * 1989-08-29 1997-05-28 Univ California Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze
AU4058297A (en) * 1996-08-08 1998-02-25 Children's Hospital Medical Center Of North America Phospholipase a2 as a marker for the presence of pulmonary fat embolism
US6267952B1 (en) * 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
US6264937B1 (en) * 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
GB0111987D0 (en) * 2001-05-16 2001-07-04 Univ Sheffield Method
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
WO2003101177A2 (en) * 2002-06-04 2003-12-11 Sequenom, Inc. Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions
AU2003248794B2 (en) * 2002-06-27 2007-10-04 Harkness Pharmaceuticals, Inc. Therapeutic methods for reducing fat deposition and treating associated conditions
WO2004002295A2 (en) * 2002-06-27 2004-01-08 Sequenom, Inc. Diagnosing predisposition to fat deposition and associated condition
US7041469B2 (en) * 2002-10-10 2006-05-09 Quidel Corporation Assays for trichomonal and other hydrolases
FR2847267B1 (fr) * 2002-11-19 2006-07-28 Coletica Procede de test de l'activite d'une substance potentiellement active pour inhiber l'activite enzymatique de la phospholipase a2
CN110452262A (zh) * 2019-08-22 2019-11-15 深圳上泰生物工程有限公司 血小板激活因子(paf)类似物的合成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833152A (en) * 1980-03-05 1989-05-23 University Of Miami Anti-hypertensive agents
DE3011061C2 (de) * 1980-03-21 1983-12-22 Siemens AG, 1000 Berlin und 8000 München Verfahren zur Intensivierung von Spül- und Reinigungsprozessen für Perforationen in Formstücken in Spül- und Reinigungsautomaten
FI63064C (fi) * 1980-04-09 1983-04-11 Ksv Chemicals Oy Foerfarande foer fluorometrisk bestaemning av aktiviteten av fettspjaelkande enzymer och medel foer att genomfoera foerfarandet
US4447445A (en) * 1983-08-03 1984-05-08 The Regents Of The University Of Calif. Manoalide, an anti-inflammatory analgesic marine natural product
US4616089A (en) * 1983-08-03 1986-10-07 University Of California Synthetic anti-inflammatory derivatives of manoalide
US4826958A (en) * 1984-12-14 1989-05-02 Abbott Laboratories Renin inhibiting compounds
EP0218696A4 (de) * 1985-04-15 1989-08-16 Biotech Res Partners Ltd Menschliches antientzündungs-phospholipase-inhibitorprotein.
DE3516001A1 (de) * 1985-05-03 1986-11-06 Boehringer Mannheim Gmbh, 6800 Mannheim Lipasefarbtest
US4835099A (en) * 1986-11-20 1989-05-30 Becton, Dickinson And Company Signal enhancement in immunoassay by modulation of enzymatic catalysis
US4788304A (en) * 1987-12-07 1988-11-29 American Home Products Corporation Phospholipase A2 inhibitors
DE3807123A1 (de) * 1988-03-04 1989-09-14 Boehringer Mannheim Gmbh Substrate fuer phospholipasen
FR2628914B1 (fr) * 1988-03-18 1990-06-29 Alcatel Thomson Faisceaux Recepteur pour systeme de transmission par voie hertzienne a diversite d'espace, comprenant un combineur de diversite
US5352673A (en) * 1989-08-29 1994-10-04 Dennis Edward A Prodrugs
US5308766A (en) * 1989-08-29 1994-05-03 The Regents Of The University Of California Hydrolytic enzyme inhibitors/inactivators and methods for using same
DE69029269T2 (de) * 1989-08-29 1997-05-28 Univ California Neue inhibitoren für hydrolytische enzyme und substrate und bestimmungsverfahren, selbige einschliessende verfahren und testsätze
US5314815A (en) * 1992-03-04 1994-05-24 The Catholic University Of America Method for temporarily inhibiting or deactivating serine hydrolase and adduct of serine hydrolase with a phosphonate or phosphate compound

Also Published As

Publication number Publication date
US5567597A (en) 1996-10-22
CA2064793C (en) 2001-11-13
ATE145672T1 (de) 1996-12-15
US5427919A (en) 1995-06-27
JP3100057B2 (ja) 2000-10-16
WO1991003544A1 (en) 1991-03-21
EP0489839A1 (de) 1992-06-17
EP0489839A4 (en) 1992-10-28
AU6353090A (en) 1991-04-08
CA2064793A1 (en) 1991-03-01
JPH05500157A (ja) 1993-01-21
DE69029269T2 (de) 1997-05-28
EP0489839B1 (de) 1996-11-27
AU643952B2 (en) 1993-12-02

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee