DE69029934T2 - Aus dem gehirn stammender neurotropher faktor - Google Patents

Aus dem gehirn stammender neurotropher faktor

Info

Publication number
DE69029934T2
DE69029934T2 DE69029934T DE69029934T DE69029934T2 DE 69029934 T2 DE69029934 T2 DE 69029934T2 DE 69029934 T DE69029934 T DE 69029934T DE 69029934 T DE69029934 T DE 69029934T DE 69029934 T2 DE69029934 T2 DE 69029934T2
Authority
DE
Germany
Prior art keywords
bdnf
nucleic acid
ngf
acid sequences
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69029934T
Other languages
English (en)
Other versions
DE69029934D1 (de
Inventor
Carolyn Hyman
Ralph Alderson
George Yancopoulos
Yves-Alain Barde
Hans Thoenen
Andreas Hohn
Friedrich Lottspeich
Ronald Lindsay
Magdalena Hofer
Joachim Leibrock
David Edgar
Bastian Hengerer
Dan Lindholm
Francisco Zafra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/400,591 external-priority patent/US5180820A/en
Application filed by Max Planck Gesellschaft zur Foerderung der Wissenschaften eV, Regeneron Pharmaceuticals Inc filed Critical Max Planck Gesellschaft zur Foerderung der Wissenschaften eV
Publication of DE69029934D1 publication Critical patent/DE69029934D1/de
Application granted granted Critical
Publication of DE69029934T2 publication Critical patent/DE69029934T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
    • F02B75/00—Other engines
    • F02B75/02—Engines characterised by their cycles, e.g. six-stroke
    • F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
    • F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
DE69029934T 1989-08-30 1990-08-29 Aus dem gehirn stammender neurotropher faktor Expired - Lifetime DE69029934T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/400,591 US5180820A (en) 1989-08-30 1989-08-30 Brain-derived neurotrophic factor
US07/570,657 US5229500A (en) 1989-08-30 1990-08-20 Brain derived neurotrophic factor
PCT/US1990/004915 WO1991003568A1 (en) 1989-08-30 1990-08-29 Brain derived neurotrophic factor

Publications (2)

Publication Number Publication Date
DE69029934D1 DE69029934D1 (de) 1997-03-27
DE69029934T2 true DE69029934T2 (de) 1997-07-24

Family

ID=27017110

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69029934T Expired - Lifetime DE69029934T2 (de) 1989-08-30 1990-08-29 Aus dem gehirn stammender neurotropher faktor

Country Status (20)

Country Link
US (2) US5229500A (de)
EP (1) EP0440777B1 (de)
KR (1) KR100188189B1 (de)
CN (1) CN1124343C (de)
AT (1) ATE148921T1 (de)
AU (1) AU647412B2 (de)
CA (1) CA2040412C (de)
DE (1) DE69029934T2 (de)
DK (1) DK0440777T3 (de)
ES (1) ES2098271T3 (de)
FI (1) FI105342B (de)
HK (1) HK1006578A1 (de)
IE (1) IE903128A1 (de)
IL (1) IL95512A0 (de)
LV (1) LV10725B (de)
NO (1) NO303584B1 (de)
PT (1) PT95152B (de)
SG (1) SG46954A1 (de)
SK (1) SK422990A3 (de)
WO (1) WO1991003568A1 (de)

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US6780837B1 (en) * 1989-08-30 2004-08-24 The Regents Of The University Of California Prevention of retinal injury and degeneration by specific factors
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
IL95511A (en) 1989-08-30 2000-10-31 Max Planck Gesellschaft Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor
US5229500A (en) * 1989-08-30 1993-07-20 Regeneron Pharmaceuticals, Inc. Brain derived neurotrophic factor
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
AU2010592A (en) * 1991-05-20 1992-12-30 Case Western Reserve University Neurotrophic factor, preparation and uses thereof
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
EP0593663A4 (en) * 1991-07-03 1996-10-30 Regeneron Pharma Method and assay system for neurotrophin activity
DE69231930T2 (de) * 1991-07-10 2002-04-11 Max Planck Gesellschaft Verfahren zur behandlung von erkrankungen motorischer neuronen durch mitglieder der bdnf/nt-3/ngf-familie
DE4237047A1 (en) * 1991-11-04 1993-05-06 I N R O Handels-Gmbh, 8750 Aschaffenburg, De Drug contg. polypeptide homologous to nerve growth factor and slow virus sequence - for treating amyotrophic lateral sclerosis, spinal muscle atrophy or Parkinson's disease
DE69328730T2 (de) * 1992-02-14 2000-09-28 Regeneron Pharma Vorbeugung von verletzungen und degenerationen von photorezeptoren durch neurotrophische faktoren
US6451763B1 (en) 1992-06-04 2002-09-17 The United States Of America As Represented By The Department Of Health And Human Services Retinal pigmented epithelium derived neurotrophic factor and methods of use
AU4406993A (en) * 1992-06-04 1993-12-30 University Of Southern California Retinal pigmented epithelium derived neurotrophic factor
DE69330809T2 (de) * 1992-06-08 2002-05-16 Takeda Chemical Industries Ltd Therapeutisches Agens für Neutropenie
AU4995193A (en) * 1992-08-04 1994-03-03 Regeneron Pharmaceuticals, Inc. Method of enhancing differentiation and survival of neuronal precursor cells
JP3431153B2 (ja) * 1992-09-03 2003-07-28 リジエネロン・フアーマシユーテイカルズ・インコーポレーテツド 背側組織作用因子及び組成物
PT662146E (pt) * 1992-09-03 2000-12-29 Univ California Factor que afecta o tecido dorsal e composicoes
US20040224409A1 (en) * 1992-09-25 2004-11-11 Laurent Pradier Recombinant adenoviruses coding for brain-derived neurotrophic factor (BDNF)
IL109280A0 (en) * 1993-04-15 1994-07-31 Regeneron Pharma Neurotrophins for treatment of depression
TW248552B (de) * 1993-06-01 1995-06-01 Onoda Yakuhin Kogyo Kk
AU7605394A (en) * 1993-09-03 1995-03-22 Regents Of The University Of California, The Neural tissue affecting factor and compositions
US6652850B1 (en) 1993-09-13 2003-11-25 Aventis Pharmaceuticals Inc. Adeno-associated viral liposomes and their use in transfecting dendritic cells to stimulate specific immunity
WO1995012686A1 (en) * 1993-11-03 1995-05-11 Cephalon, Inc. Method for screening for compounds which change the tyrosine hydroxylase content of intact cells in culture
US5556837A (en) * 1994-08-01 1996-09-17 Regeneron Pharmaceuticals Inc. Methods for treating addictive disorders
DK0788351T3 (da) * 1994-11-10 2003-05-26 Univ Kentucky Res Found Implanterbar, genopfyldelig anordning til hastighedsreguleret lægemiddeladministration direkte til en indre del af kroppen
US5770577A (en) * 1994-11-14 1998-06-23 Amgen Inc. BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
US5679783A (en) * 1994-11-22 1997-10-21 The Regents Of The University Of California DNA encoding a tissue differentiation affecting factor
US6030613A (en) 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
JP3093974B2 (ja) * 1995-06-27 2000-10-03 住友ベークライト株式会社 神経細胞用培養液、その製造方法及びこれを用いる神経細胞の培養方法
US5830857A (en) * 1995-07-14 1998-11-03 Amgen Inc. Method of treating epilepsy
US6743628B1 (en) * 1995-08-28 2004-06-01 Washington University Method of cell culture using neurturin
US5731284A (en) * 1995-09-28 1998-03-24 Amgen Inc. Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product
US6184200B1 (en) 1995-09-28 2001-02-06 Amgen Inc. Truncated glial cell line-derived neurotrophic factor
US5859311A (en) * 1995-11-27 1999-01-12 University Of Kentucky Research Foundation Transgenic mice which overexpress neurotrophin-3 (NT-3) and methods of use
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US5958875A (en) * 1996-03-29 1999-09-28 The Regents Of The University Of California Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity
GB9608335D0 (en) * 1996-04-23 1996-06-26 Univ Kingston Method of enhancing ngf-mediated neurite growth with low molecular weight analoues of p.75 ngfr 367-379
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JP4671372B2 (ja) 1996-11-15 2011-04-13 ジェネンテック， インコーポレイテッド ニューロトロフィンの精製
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AUPQ084899A0 (en) * 1999-06-08 1999-07-01 University Of Melbourne, The Neurotrophin agonists
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US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins

Also Published As

Publication number Publication date
EP0440777A1 (de) 1991-08-14
ES2098271T3 (es) 1997-05-01
IE903128A1 (en) 1991-03-13
US5229500A (en) 1993-07-20
DE69029934D1 (de) 1997-03-27
NO911689L (no) 1991-06-25
ATE148921T1 (de) 1997-02-15
PT95152A (pt) 1991-05-22
KR920701432A (ko) 1992-08-11
CA2040412A1 (en) 1991-03-01
AU6337390A (en) 1991-04-08
SK279668B6 (sk) 1999-02-11
US5438121A (en) 1995-08-01
SK422990A3 (en) 1999-02-11
CN1124343C (zh) 2003-10-15
FI912104A0 (fi) 1991-04-30
FI105342B (fi) 2000-07-31
WO1991003568A1 (en) 1991-03-21
NO911689D0 (no) 1991-04-29
PT95152B (pt) 1998-06-30
KR100188189B1 (en) 1999-06-01
AU647412B2 (en) 1994-03-24
LV10725B (en) 1995-12-20
CN1052142A (zh) 1991-06-12
EP0440777A4 (en) 1992-05-13
CA2040412C (en) 2003-03-18
SG46954A1 (en) 1998-03-20
HK1006578A1 (en) 1999-03-05
IL95512A0 (en) 1991-06-30
NO303584B1 (no) 1998-08-03
EP0440777B1 (de) 1997-02-12
DK0440777T3 (da) 1997-04-21
LV10725A (lv) 1995-06-20

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