DE69030829T2 - Reagenzien zum Nachweis von Drogen - Google Patents

Reagenzien zum Nachweis von Drogen

Info

Publication number
DE69030829T2
DE69030829T2 DE69030829T DE69030829T DE69030829T2 DE 69030829 T2 DE69030829 T2 DE 69030829T2 DE 69030829 T DE69030829 T DE 69030829T DE 69030829 T DE69030829 T DE 69030829T DE 69030829 T2 DE69030829 T2 DE 69030829T2
Authority
DE
Germany
Prior art keywords
drugs
drug
detection
reagents
hydroxysuccinimide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69030829T
Other languages
English (en)
Other versions
DE69030829D1 (de
Inventor
Salvatore Joseph Salamone
Stephen Vitone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69030829D1 publication Critical patent/DE69030829D1/de
Publication of DE69030829T2 publication Critical patent/DE69030829T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/816—Alkaloids, amphetamines, and barbiturates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y10S530/816—Attached to the carrier via a bridging agent
DE69030829T 1989-03-10 1990-03-02 Reagenzien zum Nachweis von Drogen Expired - Lifetime DE69030829T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32194689A 1989-03-10 1989-03-10

Publications (2)

Publication Number Publication Date
DE69030829D1 DE69030829D1 (de) 1997-07-10
DE69030829T2 true DE69030829T2 (de) 1998-01-15

Family

ID=23252745

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69030829T Expired - Lifetime DE69030829T2 (de) 1989-03-10 1990-03-02 Reagenzien zum Nachweis von Drogen

Country Status (12)

Country Link
US (1) US5618926A (de)
EP (1) EP0386644B1 (de)
JP (1) JP3009170B2 (de)
AT (1) ATE154135T1 (de)
AU (1) AU624686B2 (de)
CA (1) CA2011722C (de)
DE (1) DE69030829T2 (de)
DK (1) DK0386644T3 (de)
ES (1) ES2104566T3 (de)
NO (1) NO178007C (de)
NZ (1) NZ232854A (de)
ZA (1) ZA901808B (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5155212A (en) * 1986-05-21 1992-10-13 Abbott Laboratories Phencyclidine and phencyclidine metabolites assay, tracers, immunogens, antibodies and reagent kit
US5612034A (en) * 1990-10-03 1997-03-18 Redcell, Inc. Super-globuling for in vivo extended lifetimes
KR930702683A (ko) * 1990-10-22 1993-09-09 챨스 엠. 브록 항체 등에 효소 등을 커플링시키기 위한 동종이작용성 제제
ATE204385T1 (de) * 1991-06-07 2001-09-15 Johnson & Johnson Clin Diag Immunoassays unter verwendung von markierten hapten-analogen
US5284948A (en) * 1991-06-07 1994-02-08 Eastman Kodak Company Drug hapten analogues for immunoassays
US5304479A (en) * 1991-12-06 1994-04-19 Diagnostic Reagents, Inc. Phencyclidine compounds and assays for its determination
US5302715A (en) * 1992-04-06 1994-04-12 Biosite Diagnostics, Inc. Benzodiazepine derivatives
CA2096495C (en) * 1992-06-16 2002-07-09 Kathy Palmer Ordonez Dual analyte immunoassay
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
CA2167362A1 (en) * 1995-02-10 1996-08-11 Alexei Dmitri Klimov Apparatus and method for conducting a binding assay on an absorbent carrier material
EP0814843B1 (de) * 1995-03-31 2003-11-26 Xenova Research Limited Hapten-träger-konjugate zur anwendung in der drogen-missbrauchs-therapie
US5840307A (en) * 1995-03-31 1998-11-24 Immulogic Pharmacuetical Corp. Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation
DE19630102A1 (de) * 1996-07-25 1998-01-29 Boehringer Mannheim Gmbh Neue aktivierte Amphetamine
US6558956B1 (en) * 1997-06-24 2003-05-06 The University Of Wyoming Method and apparatus for detection of a controlled substance
US6770488B1 (en) 1999-03-19 2004-08-03 The University Of Wyoming Practical method and apparatus for analyte detection with colloidal particles
US6262265B1 (en) * 1999-06-18 2001-07-17 Microgenics Corporation Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
US6811998B2 (en) 1999-06-25 2004-11-02 Roche Diagnostics Operations, Inc. Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
US6921638B2 (en) 1999-06-25 2005-07-26 Amersham Biosciences Ab Hydrogel-based microarray signal amplification methods and devices therefor
GB2361473C (en) * 2000-03-08 2005-06-28 Microgenics Corp Ecstasy-class analogs and use of same in detection of ecstasy-class compounds
US6534325B1 (en) 2000-06-30 2003-03-18 Roche Diagnostics Corporation Immunoassay for the detection of amphetamines, methamphetamines and methylenedioxy designer amphetamines
US8394813B2 (en) 2000-11-14 2013-03-12 Shire Llc Active agent delivery systems and methods for protecting and administering active agents
AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US6472228B2 (en) 2000-12-04 2002-10-29 Lifepoint, Inc. Composition and methods for synthesis of novel tracers for detecting amphetamine and methamphetamine in samples
US6368814B1 (en) * 2000-12-22 2002-04-09 Roche Diagnostics Corporation Tricyclic antidepressant derivatives and immunoassay
US7141416B2 (en) * 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
US7169752B2 (en) * 2003-09-30 2007-01-30 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
AU2002335715A1 (en) * 2001-09-07 2003-03-24 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
SI1436012T1 (en) * 2001-10-18 2018-03-30 Nektar Therapeutics Polymer conjugates of opioid antagonists
EP1448992A4 (de) * 2001-11-20 2005-11-02 Burstein Technologies Inc Optische bio-disks und fluidische kreisläufe zur analyse von zellen und damit verbundene verfahren
US20050003459A1 (en) * 2002-01-30 2005-01-06 Krutzik Siegfried Richard Multi-purpose optical analysis disc for conducting assays and related methods for attaching capture agents
US6858672B2 (en) * 2002-06-20 2005-02-22 Basell Poliolefine Italia S.P.A. Safe process for making polymers containing N-phenylimide groups
CA2694876A1 (en) 2003-07-01 2005-03-24 Eric R. Diebold Electrochemical affinity biosensor system and methods
US7060847B2 (en) * 2003-07-18 2006-06-13 Roche Diagnostics Operations, Inc. Ecstasy-class derivatives, immunogens, and antibodies and their use in detecting ecstasy-class drugs
US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
EP1694363B1 (de) * 2003-12-16 2014-01-22 Nektar Therapeutics Monodisperse PEGylierte Naloxol-enthaltende Zusammensetzungen
US7220842B2 (en) * 2004-04-05 2007-05-22 Dade Behring Inc. Immunoassays for buprenorphine and norbuprenorphine
US20060024748A1 (en) * 2004-07-29 2006-02-02 Saladax Biomedical Inc. Cytoxan antibodies and immunoassay
US7238791B1 (en) * 2005-12-16 2007-07-03 Roche Diagnostics Operations, Inc. 6-monoacetylmorphine derivatives useful in immunoassay
CN101802612B (zh) 2007-07-26 2016-08-10 埃葛梅崔克斯股份有限公司 电化学分析物检测装置和方法
US8133743B2 (en) * 2007-10-19 2012-03-13 Roche Diagnostics Operations, Inc. Phenobarbital derivatives useful in immunoassay
ES2576927T3 (es) 2010-10-22 2016-07-12 T2 Biosystems, Inc. Sistemas de RMN y métodos para la detección rápida de analitos
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CN102621296A (zh) * 2012-01-06 2012-08-01 天津医科大学 一种带有间隔臂的羧化聚苯乙烯微球上偶联蛋白质的方法
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
CA3011901A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917582A (en) * 1973-06-13 1975-11-04 Syva Corp Isothiocyanate and thiourea derivatives of benzoyl ecgonine conjugated to polypeptides
US3888864A (en) * 1973-06-29 1975-06-10 Hoffmann La Roche Amino lower alkyl ether derivatives of opium alkaloids
US4340736A (en) * 1976-05-26 1982-07-20 Hoffmann-La Roche Inc. Diagnostic test for barbiturates
US4101549A (en) * 1976-05-26 1978-07-18 Hoffmann-La Roche Inc. Aminophenyl esters of 5-carboxyalkyl barbituric acids
IL49685A (en) * 1976-05-31 1978-10-31 Technion Res & Dev Foundation Specific binding assay method for determining the concentration of materials and reagent means therefor
US4196185A (en) * 1978-06-05 1980-04-01 Hoffmann-La Roche Inc. Immunoassay for phencyclidine
US4223013A (en) * 1978-12-29 1980-09-16 Syva Company Amitriptyline conjugates to antigenic proteins and enzymes
US4275160A (en) * 1979-07-06 1981-06-23 Syva Company Imipramine derivatives and poly(amino acid) conjugates
US4351760A (en) * 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US4262089A (en) * 1980-04-07 1981-04-14 Syva Company Theophylline antigens and antibodies
EP0045334B1 (de) * 1980-08-04 1984-03-14 Syva Company Antigene Zusammensetzungen des Propranolols und Antikörper und Verfahren zu deren Verwendung
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4401765A (en) * 1981-09-01 1983-08-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4424150A (en) * 1982-04-02 1984-01-03 Syva Company Acetaminophen analogs, antigens, and antibodies
ATE126695T1 (de) * 1982-05-18 1995-09-15 Univ Florida Gehirnspezifische arzneimittelabgabe.
US4629691A (en) * 1983-08-01 1986-12-16 Syntex (U.S.A.) Inc. Tricyclic antidepressant conjugates with antigens and enzymes
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
EP0199042A1 (de) * 1985-03-26 1986-10-29 Abbott Laboratories Probe, Tracers, Immunogene und Antikörper von Procainamid
US4680338A (en) * 1985-10-17 1987-07-14 Immunomedics, Inc. Bifunctional linker
ES2093601T3 (es) * 1987-02-17 1997-01-01 Abbott Lab Inmunoensayo de polarizacion de fluorescencia para tetrahidrocannabinoides.
US4791067A (en) * 1987-06-25 1988-12-13 Fisher Scientific Co. Agglutination immunoassay for hapten involving monoclonal antibody of IgA class reagent

Also Published As

Publication number Publication date
EP0386644A2 (de) 1990-09-12
ZA901808B (en) 1990-12-28
AU5123190A (en) 1990-11-22
AU624686B2 (en) 1992-06-18
EP0386644A3 (de) 1992-10-07
US5618926A (en) 1997-04-08
NZ232854A (en) 1993-03-26
DK0386644T3 (da) 1997-10-13
NO901122L (no) 1990-09-11
JP3009170B2 (ja) 2000-02-14
NO178007B (no) 1995-09-25
ATE154135T1 (de) 1997-06-15
NO901122D0 (no) 1990-03-09
CA2011722C (en) 2001-06-19
DE69030829D1 (de) 1997-07-10
ES2104566T3 (es) 1997-10-16
CA2011722A1 (en) 1990-09-10
NO178007C (no) 1996-01-03
JPH03200763A (ja) 1991-09-02
EP0386644B1 (de) 1997-06-04

Similar Documents

Publication Publication Date Title
DE69030829D1 (de) Reagenzien zum Nachweis von Drogen
ES2060610T3 (es) Nuevos derivados del cannabinol e inmunoensayo perfeccionado.
FI905614A0 (fi) Diagnostisering och behandling av insulinberoende sockersjuka.
ATE222254T1 (de) Verwendung von einem metalloporphyrinkonjugat für den nachweis biologischer verbindungen
ATE369878T1 (de) Träger-pharmaka-konjugate
ES2080056T3 (es) Reactivos para la captura de iones y metodos para la realizacion de ensayos.
DE3145082A1 (de) "ein latex, biologisch aktive latexkonjugate und verfahren zu ihrer herstellung"
ES2045216T3 (es) Inmunoensayo y derivados polimeros de igg para la compensacion de factores de perturbacion en el inmunoensayo.
KR900007861A (ko) 스핀고이드 부분에서 반응성 그룹을 갖는 글리코스핀고리피드, 이의 제조방법 및 이를 커플링시켜 수득한 강글리오사이드 유도체
ES2169730T3 (es) Patron sintetico para analisis inmunologicos.
BR9812649A (pt) Compostos contendo anéis de seis membros, processo para sua preparação, e seu uso como medicamentos
EP0256551A3 (de) Hapten-Makromolekül-Konjugaten zur Verwendung in Haptenassays
Levine The preparation of penicilloyl-polylysines, skin test reagents for the clinical evaluation of penicillin hypersensitivity
EP0383124A3 (de) Redoxpolymerisierungstestzusammensetzung und Verfahren zum Immuntest und Nukleinsäuretest
CA2004642A1 (en) Process for the detection of compounds containing carbohydrate and a suitable reagent therefor
DE69025023D1 (de) Peptide und deren Benutzung
FR2627986B1 (fr) Composition pharmaceutique a base de 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazol-4-one ou d'un de ses sels et de dexamethasone, son procede de preparation et ses utilisations
ATE143142T1 (de) Immunoassay zum nachweis von antikörpern gegen hiv
CA2050941A1 (en) Antibody to smooth muscle myosin heavy chains
BR0113579A (pt) Proteìnas sintéticas modificadas por polìmero
EP0292170A3 (de) Enzym-Immunoassay
ATE66602T1 (de) Verwendung von nitrophenylgruppen zur stimulierung der inkorporationsfaehigkeit eines arzneimittels in die empfindlichen wirtszellen.
DE69010784T2 (de) Diallyloxyessigsäure und ihre basische Additionssalze, ihre Herstellungsverfahren und Verwendung als Retikularmittel.

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8364 No opposition during term of opposition