DE69034061D1 - Methode der veränderung der expression von genen bei der transkription und zum nachweis von chemischen substanzen, die wie modulatoren der genexpression wirken - Google Patents
Methode der veränderung der expression von genen bei der transkription und zum nachweis von chemischen substanzen, die wie modulatoren der genexpression wirkenInfo
- Publication number
- DE69034061D1 DE69034061D1 DE69034061T DE69034061T DE69034061D1 DE 69034061 D1 DE69034061 D1 DE 69034061D1 DE 69034061 T DE69034061 T DE 69034061T DE 69034061 T DE69034061 T DE 69034061T DE 69034061 D1 DE69034061 D1 DE 69034061D1
- Authority
- DE
- Germany
- Prior art keywords
- expression
- gene
- cell
- protein
- modulators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
- C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
- C12Y113/12007—Photinus-luciferin 4-monooxygenase (ATP-hydrolysing) (1.13.12.7), i.e. firefly-luciferase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38271289A | 1989-07-18 | 1989-07-18 | |
PCT/US1990/004021 WO1991001379A1 (en) | 1989-07-18 | 1990-07-18 | Method of transcriptionally modulating gene expression and of discovering chemicals capable of functioning as gene expression modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69034061D1 true DE69034061D1 (de) | 2003-05-28 |
Family
ID=23510077
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69034061T Expired - Lifetime DE69034061D1 (de) | 1989-07-18 | 1990-07-18 | Methode der veränderung der expression von genen bei der transkription und zum nachweis von chemischen substanzen, die wie modulatoren der genexpression wirken |
Country Status (9)
Country | Link |
---|---|
US (1) | US5863733A (de) |
EP (1) | EP0483249B1 (de) |
JP (1) | JPH04506902A (de) |
KR (1) | KR100194562B1 (de) |
AT (1) | ATE238431T1 (de) |
AU (1) | AU660405B2 (de) |
CA (1) | CA2063822C (de) |
DE (1) | DE69034061D1 (de) |
WO (1) | WO1991001379A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU652576B2 (en) | 1990-09-13 | 1994-09-01 | Duke University | Expression of G protein coupled receptors in yeast |
US5721096A (en) * | 1991-01-24 | 1998-02-24 | Children's Medical Center Corporation | Methods of screening for compounds with ability to alter apolipoprotein AI gene expression |
CA2070058A1 (en) * | 1991-05-31 | 1992-12-01 | Robert A. Gadski | Vectors and methods for assaying the regulation of apolipoprotein ai synthesis |
GB9113097D0 (en) * | 1991-06-18 | 1991-08-07 | Boehringer Ingelheim Int | Chimeric gene |
US6071695A (en) * | 1992-02-21 | 2000-06-06 | Creative Biomolecules, Inc. | Methods and products for identification of modulators of osteogenic protein-1 gene expression |
PT566554E (pt) * | 1992-03-13 | 2000-09-29 | Monsanto Co | Producao de proteinas recombinantes usando promotores do virus de herpes e transactivadores vp16 |
DK0680517T4 (da) * | 1993-01-21 | 2005-05-02 | Harvard College | Fremgangsmåde og diagnostiske sæt til bestemmelse af en forbindelses toksicitet under anvendelse afstress-promotorer fra pattedyr |
DE4311835A1 (de) * | 1993-04-07 | 1994-10-13 | Boehringer Ingelheim Int | Verfahren zur Inhibierung der Transkription von Genen |
US5445941A (en) * | 1993-06-21 | 1995-08-29 | Eli Lilly And Company | Method for screening anti-osteoporosis agents |
US7306903B1 (en) * | 1995-07-26 | 2007-12-11 | Curis, Inc. | Methods and compositions for identifying morphogen analogs |
WO1997014812A2 (en) * | 1995-10-16 | 1997-04-24 | Chiron Corporation | Method of screening for factors that modulate gene expression |
US6566089B1 (en) * | 1996-09-04 | 2003-05-20 | Tularik Inc. | Cell-based drug screens for regulators of gene expression |
US5928888A (en) * | 1996-09-26 | 1999-07-27 | Aurora Biosciences Corporation | Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities |
US6586661B1 (en) * | 1997-06-12 | 2003-07-01 | North Carolina State University | Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid |
US6153383A (en) | 1997-12-09 | 2000-11-28 | Verdine; Gregory L. | Synthetic transcriptional modulators and uses thereof |
AU4210700A (en) * | 1999-04-09 | 2000-11-14 | Iconix Pharmaceuticals, Inc. | Methods and nucleic acid vectors for rapid and parallel assay development, for characterization of the activities of biological response modifiers |
US6680344B1 (en) | 1999-06-01 | 2004-01-20 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylmethane derivatives |
MXPA01012493A (es) | 1999-06-01 | 2003-09-10 | Univ Texas Southwestern Med Ct | Metodo para tratar la perdida capilar con el uso de derivados de eter difenilico. |
US6646005B1 (en) | 1999-06-01 | 2003-11-11 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using sulfonyl thyromimetic compounds |
DE19926216A1 (de) * | 1999-06-09 | 2001-02-22 | Metallgesellschaft Ag | Verfahren zur Herstellung von Bariumsulfat, Bariumsulfat und Verwendung des Bariumsulfats |
US6673554B1 (en) * | 1999-06-14 | 2004-01-06 | Trellie Bioinformatics, Inc. | Protein localization assays for toxicity and antidotes thereto |
US6653064B1 (en) | 1999-09-23 | 2003-11-25 | Boehringer Ingelheim International Gmbh | Method for identifying compounds useful in the therapy of bone disorders |
EP1363946A2 (de) * | 2000-06-13 | 2003-11-26 | The Board Of Trustees Of The University Of Arkansas | Verfahren zur differentierung zwischen nicht-genotropische und genotropische aktivität von steroidrezeptoren |
DE60121603T2 (de) * | 2000-08-30 | 2007-06-21 | North Carolina State University | Transgene pflanzen, die molekulare decoys enthalten, die den proteininhalt ändern |
CA2427472A1 (en) | 2000-10-27 | 2002-06-06 | Tae Kook Kim | Double and triple readout assay systems |
EP1368467B1 (de) * | 2000-11-07 | 2007-04-25 | North Carolina State University | Putrescin-n-methyltransferasepromotor |
CA2327581A1 (en) * | 2000-12-27 | 2002-06-27 | Yves Blais | Methods and compositions for the establishment of genetically altered cell-based library designed for monitoring transcriptional activity of compounds and molecules |
US20060157072A1 (en) * | 2001-06-08 | 2006-07-20 | Anthony Albino | Method of reducing the harmful effects of orally or transdermally delivered nicotine |
WO2002100199A2 (en) * | 2001-06-08 | 2002-12-19 | Vector Tobacco Ltd. | Modifying nicotine and nitrosamine levels in tobacco |
WO2003082800A1 (en) * | 2002-04-01 | 2003-10-09 | The University Of Alberta | Compounds that stimulate glucose utilization and methods of use |
IL164204A0 (en) * | 2002-04-09 | 2005-12-18 | Vector Tobacco Ltd | Tobacco having reduced nicotine and nitrosamines |
US20060247192A1 (en) * | 2002-12-05 | 2006-11-02 | Jenkinson John D | Control of apoptosis |
WO2007140253A2 (en) * | 2006-05-26 | 2007-12-06 | Temple University - Of The Commonwealth System Of Higher Education | Treatment of hiv-1 by modulation of vpr activation of the m-csf promoter |
EP2765227A3 (de) | 2010-04-06 | 2014-12-10 | The George Washington University | Zusammensetzungen und Verfahren zur Identifikation von Störungen aus dem Autismusspektrum |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4535058A (en) * | 1982-10-01 | 1985-08-13 | Massachusetts Institute Of Technology | Characterization of oncogenes and assays based thereon |
US4699877A (en) * | 1982-11-04 | 1987-10-13 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
US4601978A (en) * | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
US4713339A (en) * | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
US4827079A (en) * | 1983-08-22 | 1989-05-02 | Dna Plant Technology Corporation | Generation of somaclonal non-mendelian variants |
US4740461A (en) * | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
US4740463A (en) * | 1984-04-13 | 1988-04-26 | Massachusetts Institute Of Technology | Methods and artificial genes for antagonizing the function of an oncogene |
US4738922A (en) * | 1984-05-25 | 1988-04-19 | Dana Farber Cancer Institute | Trans-acting transcriptional factors |
US4736866A (en) * | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
US4761367A (en) * | 1984-11-07 | 1988-08-02 | The University Of North Carolina At Chapel Hill | Vectors suitable for detection of eukaryotic DNA regulatory sequences |
US4761371A (en) * | 1985-02-12 | 1988-08-02 | Genentech, Inc. | Insulin receptor |
US4861709A (en) * | 1985-05-31 | 1989-08-29 | Technicon Research A.G. | Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker |
US4981783A (en) * | 1986-04-16 | 1991-01-01 | Montefiore Medical Center | Method for detecting pathological conditions |
US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
US5071773A (en) * | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
US4935363A (en) * | 1987-03-30 | 1990-06-19 | Board Of Regents, The University Of Texas System | Sterol regulatory elements |
US4885238A (en) * | 1987-10-30 | 1989-12-05 | The United States Of America As Represented By The Department Of Health And Human Services | Immortalized human bronchial epitherial mesothelial cell lines |
US5075229A (en) * | 1987-06-16 | 1991-12-24 | Ohio University Edison Animal Biotechnology Center | Dietary and hormonal regulation of expression of exogenous genes in transgenic animals under control of the promoter of the gene for phosphoenolpyruvate carboxykinase |
JPH03502040A (ja) * | 1987-09-21 | 1991-05-16 | アムラド・コーポレイション・リミテッド | Gm‐csf遺伝子発現の調節 |
EP0332104A3 (de) * | 1988-03-08 | 1991-03-20 | Ciba-Geigy Ag | Chemisch regulierte Sequenzen und Gene, und ihre Verwendungen |
US5070012A (en) * | 1988-03-30 | 1991-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Monitoring of cells and trans-activating transcription elements |
US5262300A (en) * | 1988-11-30 | 1993-11-16 | The Salk Institute For Biological Studies | Receptors: their identification, characterization, preparation and use |
-
1990
- 1990-07-18 KR KR1019920700119A patent/KR100194562B1/ko not_active IP Right Cessation
- 1990-07-18 EP EP90911558A patent/EP0483249B1/de not_active Revoked
- 1990-07-18 AT AT90911558T patent/ATE238431T1/de not_active IP Right Cessation
- 1990-07-18 CA CA002063822A patent/CA2063822C/en not_active Expired - Lifetime
- 1990-07-18 AU AU61400/90A patent/AU660405B2/en not_active Expired
- 1990-07-18 WO PCT/US1990/004021 patent/WO1991001379A1/en not_active Application Discontinuation
- 1990-07-18 JP JP2511061A patent/JPH04506902A/ja active Pending
- 1990-07-18 DE DE69034061T patent/DE69034061D1/de not_active Expired - Lifetime
-
1997
- 1997-01-06 US US08/779,230 patent/US5863733A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0483249A4 (de) | 1994-04-06 |
KR920703836A (ko) | 1992-12-18 |
US5863733A (en) | 1999-01-26 |
AU6140090A (en) | 1991-02-22 |
JPH04506902A (ja) | 1992-12-03 |
EP0483249A1 (de) | 1992-05-06 |
ATE238431T1 (de) | 2003-05-15 |
KR100194562B1 (ko) | 1999-06-15 |
CA2063822A1 (en) | 1991-01-19 |
EP0483249B1 (de) | 2003-04-23 |
CA2063822C (en) | 2006-10-03 |
AU660405B2 (en) | 1995-06-29 |
WO1991001379A1 (en) | 1991-02-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |