DE69115934D1 - Synthetische knochenbildungsschicht - Google Patents

Synthetische knochenbildungsschicht

Info

Publication number
DE69115934D1
DE69115934D1 DE69115934T DE69115934T DE69115934D1 DE 69115934 D1 DE69115934 D1 DE 69115934D1 DE 69115934 T DE69115934 T DE 69115934T DE 69115934 T DE69115934 T DE 69115934T DE 69115934 D1 DE69115934 D1 DE 69115934D1
Authority
DE
Germany
Prior art keywords
inducing
bone formation
formation layer
synthetic bone
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69115934T
Other languages
English (en)
Other versions
DE69115934T2 (de
Inventor
Thangavel Kuberasampath
Tarrant Berlowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stryker Corp
Original Assignee
Stryker Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stryker Corp filed Critical Stryker Corp
Application granted granted Critical
Publication of DE69115934D1 publication Critical patent/DE69115934D1/de
Publication of DE69115934T2 publication Critical patent/DE69115934T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
DE69115934T 1990-05-29 1991-05-22 Synthetische knochenbildungsschicht Expired - Fee Related DE69115934T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/529,852 US5645591A (en) 1990-05-29 1990-05-29 Synthetic bone matrix
PCT/US1991/003603 WO1991018558A1 (en) 1990-05-29 1991-05-22 Synthetic bone matrix

Publications (2)

Publication Number Publication Date
DE69115934D1 true DE69115934D1 (de) 1996-02-08
DE69115934T2 DE69115934T2 (de) 1996-05-23

Family

ID=24111509

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69115934T Expired - Fee Related DE69115934T2 (de) 1990-05-29 1991-05-22 Synthetische knochenbildungsschicht

Country Status (11)

Country Link
US (4) US5645591A (de)
EP (1) EP0608211B1 (de)
JP (1) JP2679409B2 (de)
AT (1) ATE132043T1 (de)
AU (1) AU639574B2 (de)
CA (1) CA2082946C (de)
DE (1) DE69115934T2 (de)
DK (1) DK0608211T3 (de)
ES (1) ES2081484T3 (de)
GR (1) GR3019339T3 (de)
WO (1) WO1991018558A1 (de)

Families Citing this family (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586388B2 (en) * 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
DE68929453T2 (de) * 1988-04-08 2003-11-20 Stryker Corp Osteogene Vorrichtungen
US6919308B2 (en) * 1988-04-08 2005-07-19 Stryker Corporation Osteogenic devices
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US7056882B2 (en) * 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
CA2363965C (en) 1991-03-11 2010-05-18 Curis, Inc. Protein-induced morphogenesis
US6211146B1 (en) 1991-03-11 2001-04-03 Curis, Inc. 60A protein-induced morphogenesis
US6399569B1 (en) * 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
ATE203166T1 (de) * 1991-03-11 2001-08-15 Curis Inc Protein-induzierende morphogenese
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
US5306305A (en) * 1992-01-31 1994-04-26 Etex Corporation Methods of coating implants with bony structure
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US6352707B1 (en) 1992-02-24 2002-03-05 Anton-Lewis Usala Transplant encapsulation in a hydrogel matrix to obscure immune recognition
ES2114073T3 (es) 1992-09-16 1998-05-16 Creative Biomolecules Inc Regeneracion del higado inducida por morfogenes.
US5906827A (en) * 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US5782919A (en) 1995-03-27 1998-07-21 Sdgi Holdings, Inc. Interbody fusion device and method for restoration of normal spinal anatomy
US6206922B1 (en) 1995-03-27 2001-03-27 Sdgi Holdings, Inc. Methods and instruments for interbody fusion
ATE286696T1 (de) * 1995-03-27 2005-01-15 Sdgi Holdings Inc Wirbelsäulenfusionsimplantat und einführ- und überprüfungswerkzeuge
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US5989289A (en) 1995-10-16 1999-11-23 Sdgi Holdings, Inc. Bone grafts
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US7026292B1 (en) * 1995-12-12 2006-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US6221854B1 (en) * 1996-03-05 2001-04-24 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US20110207666A1 (en) * 1996-03-05 2011-08-25 Depuy Spine, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
CA2269342C (en) 1996-10-23 2006-09-12 Sdgi Holdings, Inc. Spinal spacer
US20050165483A1 (en) * 2004-01-27 2005-07-28 Ray Eddie F.Iii Bone grafts
CN1113672C (zh) * 1996-11-05 2003-07-09 嘉年生化产品有限公司 用京尼平对生物医学材料进行化学改性
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
KR100237738B1 (ko) * 1997-04-26 2000-01-15 이용찬 생채 매식용 의료기구 임플란트의 기능 향상방법
EP0902036A1 (de) 1997-09-05 1999-03-17 Roche Diagnostics GmbH Peptide mit einem Arginine-Substitut für die Behandlung von Osteoporosis, deren Herstellung und diese enthaltende Verbindungen
DE69840361D1 (de) 1997-07-30 2009-01-29 Univ Emory Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
US6911553B1 (en) 1997-10-02 2005-06-28 Roche Diagnostics Gmbh Osteoblast-specific mitogens and drugs containing such compounds
EP0906759A1 (de) 1997-10-02 1999-04-07 Roche Diagnostics GmbH Neue Osteoblastenspezifische Mitogene: Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US6214049B1 (en) 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
WO1999030632A1 (en) * 1997-12-18 1999-06-24 Comfort Biomedical, Inc. Bone augmentation for prosthetic implants and the like
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6123731A (en) * 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US20030147860A1 (en) * 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
US6083264A (en) * 1998-06-30 2000-07-04 Mcdonnell Douglas Corporation Implant material for replacing or augmenting living bone tissue involving thermoplastic syntactic foam
EP1094849B1 (de) * 1998-07-10 2006-05-17 Encelle, Inc. Methoden zur verbesserung der vaskularisierung und förderung der wundheilung
WO2000015273A1 (de) * 1998-09-11 2000-03-23 Gerhard Schmidmaier Biologisch aktive implantate
DE19855890A1 (de) * 1998-12-03 2000-06-08 Nerlich Michael Poröse Kompositmatrix, deren Herstellung und Verwendung
US6663870B2 (en) 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
US6206923B1 (en) * 1999-01-08 2001-03-27 Sdgi Holdings, Inc. Flexible implant using partially demineralized bone
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
US6113638A (en) 1999-02-26 2000-09-05 Williams; Lytton A. Method and apparatus for intervertebral implant anchorage
US6468543B1 (en) 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
WO2001000792A1 (en) 1999-06-29 2001-01-04 Marchosky J Alexander Compositions and methods for forming and strengthening bone
DE19952550A1 (de) * 1999-11-02 2001-05-03 Tutogen Medical Gmbh Knochenimplantat
US6368787B1 (en) 1999-12-16 2002-04-09 Stryker Corporation Methods and compositions for identifying morphogenic protein analogs using morphogenic protein responsive inhibitory elements
WO2001057083A1 (en) * 2000-02-04 2001-08-09 Zymogenetics, Inc. Methods for promoting growth of bone, ligament, and cartilage using zvegf4
AU2001265151A1 (en) * 2000-05-31 2001-12-11 Encelle, Inc. Method of stimulating hair growth
DE60132596T2 (de) 2000-08-03 2009-02-19 Roche Diagnostics Gmbh NUKLEINSÄUREBINDENDE VERBINDUNGEN MIT PYRAZOLOi3,4-D PYRIMIDINANALOGEN VON PURIN-2,6-DIAMIN UND IHRE VERWENDUNG
ATE334644T1 (de) * 2000-10-11 2006-08-15 Michael D Mason Wirbelfusionsvorrichtung
JP2004512097A (ja) * 2000-10-24 2004-04-22 エスディージーアイ・ホールディングス・インコーポレーテッド 骨原性材料を充填する装置および方法
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
GB0115320D0 (en) * 2001-06-22 2001-08-15 Univ Nottingham Matrix
US7708776B1 (en) 2002-01-16 2010-05-04 Nuvasive, Inc. Intervertebral disk replacement system and methods
KR100481214B1 (ko) * 2002-02-09 2005-04-08 엘지.필립스 엘시디 주식회사 방전관 램프의 구동장치 및 구동방법과 이를 이용한액정표시장치
NZ535136A (en) 2002-02-21 2006-03-31 Encelle Inc Immobilized bioactive hydrogel matrices as surface coatings
US20080086792A1 (en) 2006-10-13 2008-04-17 Thomas Charles Kuracina Method and apparatus for diverting sweat, liquid, moisture or the like from an eye
DE60334897D1 (de) * 2002-03-30 2010-12-23 Infinity Orthopaedics Co Ltd Medizinische Intervertebrale Vorrichtung
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
EP1534191A4 (de) * 2002-08-20 2010-11-03 Exactech Inc Zusammensetzung zum tragen und abgeben von das knochenwachstum induzierendem material und verfahren zur herstellung und applikation der zusammensetzung
JP4681214B2 (ja) * 2003-06-10 2011-05-11 グンゼ株式会社 コラーゲンスポンジの製造方法及び人工皮膚の製造方法
US9364330B2 (en) 2003-06-25 2016-06-14 Biedermann Technologies Gmbh & Co. Kg Tissue integration design for seamless implant fixation
US20050020506A1 (en) * 2003-07-25 2005-01-27 Drapeau Susan J. Crosslinked compositions comprising collagen and demineralized bone matrix, methods of making and methods of use
AU2004285480B2 (en) * 2003-10-22 2010-12-16 Encelle, Inc. Bioactive hydrogel compositions for regenerating connective tissue
ITPD20030286A1 (it) 2003-11-27 2005-05-28 Fidia Advanced Biopolymers Srl Strutture composite multistrato contenenti acido ialuronico
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
ES2329153T3 (es) 2004-04-15 2009-11-23 Nexilis Ag Compuesto de matriz osteogenico, procedimiento para su preparacion asi como implante y andamiaje bioactivo para la ingenieria tisular con un recubrimiento de un compuesto de matriz osteogenico.
ES2342551T3 (es) * 2004-06-16 2010-07-08 Affinergy Inc Biomateriales interfaciales (ifbm) para promover la adhesion especifica de substancias a analizar.
US8500843B2 (en) * 2004-07-02 2013-08-06 Praxis Powder Technology, Inc. Controlled porosity article
US7674426B2 (en) * 2004-07-02 2010-03-09 Praxis Powder Technology, Inc. Porous metal articles having a predetermined pore character
US20100094420A1 (en) * 2004-07-02 2010-04-15 Grohowski Jr Joseph A Porous Bone Fixation Device
US9089427B2 (en) 2004-07-02 2015-07-28 Praxis Powder Technology, Inc. Method of making porous metal articles
TW200714289A (en) * 2005-02-28 2007-04-16 Genentech Inc Treatment of bone disorders
US20060293227A1 (en) * 2005-06-24 2006-12-28 Bhatnagar Rajendra S Cosmetic compositions and methods using transforming growth factor-beta mimics
JP2009507103A (ja) * 2005-09-02 2009-02-19 コルバー・ライフサイエンス・リミテツド 架橋多糖およびタンパク質マトリックスならびにそれらの製造方法
US7618459B2 (en) * 2005-09-26 2009-11-17 Infinity Orthopedics Ltd. Universal spinal disc implant system
US20070077267A1 (en) * 2005-10-03 2007-04-05 Sdgi Holdings, Inc. Bioactive composite implants
US7749555B2 (en) * 2006-01-25 2010-07-06 Medtronic, Inc Modification of chemical forces of bone constructs
US20070179618A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US20070179615A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
JP2009529374A (ja) * 2006-03-07 2009-08-20 アクスル インターナショナル 治療及び癒着防止用生物活性スキャホールド
US7771741B2 (en) * 2006-05-01 2010-08-10 Warsaw Orthopedic, Inc Demineralized bone matrix devices
US20100209470A1 (en) * 2006-05-01 2010-08-19 Warsaw Orthopedic, Inc. An Indiana Corporation Demineralized bone matrix devices
US8506983B2 (en) * 2006-05-01 2013-08-13 Warsaw Orthopedic, Inc. Bone filler material
US7838022B2 (en) 2006-05-01 2010-11-23 Warsaw Orthopedic, Inc Malleable implants containing demineralized bone matrix
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
PT2097116E (pt) 2006-12-22 2012-12-06 Medidom Lab Sistema in situ para reparação de tecido intra-articular condral e ósseo
US20090287309A1 (en) 2007-01-30 2009-11-19 Tornier Sas Intra-articular joint replacement
FR2911773B1 (fr) 2007-01-30 2009-03-27 Tornier Sas Methode et ensemble d'instrumentation chirurgicale pour poser une prothese totale d'epaule inversee,et prothese correspondante
US9056150B2 (en) * 2007-12-04 2015-06-16 Warsaw Orthopedic, Inc. Compositions for treating bone defects
US20090202642A1 (en) * 2008-02-08 2009-08-13 Xiao Huang Drug Delivery System Comprising Microparticles and Gelation System
US8840913B2 (en) * 2008-03-27 2014-09-23 Warsaw Orthopedic, Inc. Malleable multi-component implants and materials therefor
CN104491845A (zh) 2008-04-18 2015-04-08 科尔普兰特有限公司 产生和使用原胶原的方法
US10806833B1 (en) 2009-05-11 2020-10-20 Integra Lifesciences Corporation Adherent resorbable matrix
US9408652B2 (en) 2010-04-27 2016-08-09 Tornier Sas Intra-articular joint replacement and method
AU2011329054B2 (en) 2010-11-15 2015-05-28 Zimmer Orthobiologics, Inc. Bone void fillers
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
CA2854160A1 (en) 2011-11-02 2013-05-10 Halscion, Inc. Methods and compositions for wound treatment
ES2784223T3 (es) 2012-06-20 2020-09-23 Univ Virginia Patent Foundation Composiciones y procedimientos para regular la homeostasis de glucosa y la acción de insulina
US9370609B2 (en) 2013-01-08 2016-06-21 Praxis Powder Technology, Inc. High strength injection molded orthopedic devices
US9138317B2 (en) 2013-03-14 2015-09-22 Osteoceramics, Inc Conduits for enhancing tissue regeneration
EP2967875B1 (de) 2013-03-15 2017-12-20 Osteoceramics, Inc. Vorrichtungen zum verlängern von knochen
JP2020520949A (ja) 2017-05-22 2020-07-16 ユニバーシティ オブ ヴァージニア パテント ファウンデーションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｖｅｒｇｉｎｉａ Ｐａｔｅｎｔ Ｆｏｕｎｄａｔｉｏｎ 組成物、並びにミトコンドリア脱共役剤を調製及び使用する方法
CN112262141A (zh) 2018-04-20 2021-01-22 弗吉尼亚理工大学知识产权有限公司 可用作线粒体解偶联剂的咪唑吡啶
US11090412B2 (en) * 2018-12-21 2021-08-17 Zavation Medical Products Llc Bone repair composition and kit

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3551560A (en) * 1967-10-02 1970-12-29 Heinrich F Thiele Process of reconstructing tendons,cartilage,nerve sheaths,and products
CA962806A (en) * 1970-06-04 1975-02-18 Ontario Research Foundation Surgical prosthetic device
US4172128A (en) * 1975-03-26 1979-10-23 Erhard Thiele Process of degrading and regenerating bone and tooth material and products
US4280954A (en) * 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
GB1515963A (en) * 1975-07-15 1978-06-28 Massachusetts Inst Technology Crosslinked collagen-mucopolysaccharide composite materials
US4060081A (en) * 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4378224A (en) * 1980-09-19 1983-03-29 Nimni Marcel E Coating for bioprosthetic device and method of making same
DE3124981A1 (de) * 1981-06-25 1983-01-13 Dr. Ruhland Nachfolger GmbH, 8425 Neustadt Wirkstoffhaltige kollageneinlage zum einfuehren in knochen oder weichteile und verfahren zu deren herstellung
US4350629A (en) * 1981-07-29 1982-09-21 Massachusetts Institute Of Technology Procedures for preparing composite materials from collagen and glycosaminoglycan
US4394370A (en) * 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4418691A (en) * 1981-10-26 1983-12-06 Massachusetts Institute Of Technology Method of promoting the regeneration of tissue at a wound
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4787900A (en) * 1982-04-19 1988-11-29 Massachusetts Institute Of Technology Process for forming multilayer bioreplaceable blood vessel prosthesis
US4544516A (en) * 1982-07-28 1985-10-01 Battelle Development Corporation Collagen orientation
US4661111A (en) * 1982-08-04 1987-04-28 La Jolla Cancer Research Foundation Polypeptide
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4448718A (en) * 1983-09-13 1984-05-15 Massachusetts Institute Of Technology Method for the preparation of collagen-glycosaminoglycan composite materials
GB2148901A (en) * 1983-10-04 1985-06-05 Johnson & Johnson Protein/polysaccharide complexes
NZ210699A (en) * 1984-01-04 1989-06-28 Int Genetic Eng Isolation of an osteogenic protein of the p3 immunologically related family
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
US4620327A (en) * 1984-07-05 1986-11-04 Caplan Arnold I Process of adapting soluble bone protein for use in stimulating osteoinduction
US4789663A (en) * 1984-07-06 1988-12-06 Collagen Corporation Methods of bone repair using collagen
WO1986000525A1 (en) 1984-07-13 1986-01-30 Economix Közgazdász Egyetemi Kisszövetkezet Process for the preparation of a pharmaceutical composition influencing the tissue metabolism and having a regenerating action
EP0169001A3 (en) * 1984-07-17 1987-11-25 Collagen Corporation Collagen coated bone implants
DE3429038A1 (de) * 1984-08-07 1986-02-20 B. Braun Melsungen Ag, 3508 Melsungen Wirkstoff-depot
FR2569723B1 (fr) 1984-08-31 1986-09-19 Centre Nat Rech Scient Application des antibiotiques de la famille des phleomycines a titre d'agent de selection dans le domaine du genie genetique
US4657548A (en) * 1984-09-11 1987-04-14 Helitrex, Inc. Delivery system for implantation of fine particles in surgical procedures
GB8425761D0 (en) 1984-10-11 1984-11-14 Raychem Sa Nv Remote measurement of conditions
US4888366A (en) * 1984-10-24 1989-12-19 Collagen Corporation Inductive collagen-based bone repair preparations
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
JPS61154567A (ja) * 1984-12-26 1986-07-14 生化学工業株式会社 架橋グリコサミノグリカン複合体
CA1260391A (en) * 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
US4627853A (en) * 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
IL75554A (en) * 1985-06-18 1993-01-14 Yeda Res & Dev Matrix for cell cultivation in vitro
FR2585576B1 (fr) * 1985-07-30 1992-01-03 Bioetica Sa Produit de remplacement de la matrice osseuse favorisant l'osteogenese
IL76079A (en) * 1985-08-13 1991-03-10 Univ Ramot Collagen implants
ATE87469T1 (de) * 1985-12-27 1993-04-15 Sumitomo Pharma Verfahren zur herstellung einer formulierung mit verzoegerter freisetzung.
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US5124316A (en) * 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
JPH0773601B2 (ja) * 1987-03-27 1995-08-09 柳沢 定勝 生体の補填補綴材料
US5258043A (en) * 1987-07-20 1993-11-02 Regen Corporation Method for making a prosthetic intervertebral disc
US4880429A (en) * 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US5007934A (en) * 1987-07-20 1991-04-16 Regen Corporation Prosthetic meniscus
US4947840A (en) * 1987-08-21 1990-08-14 Massachusetts Institute Of Technology Biodegradable templates for the regeneration of tissues
US4812120A (en) * 1987-11-02 1989-03-14 Flanagan Dennis F Implantable percutaneous device
GB2215209B (en) * 1988-03-14 1992-08-26 Osmed Inc Method and apparatus for biodegradable, osteogenic, bone graft substitute device
US5266683A (en) 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
DE68929453T2 (de) * 1988-04-08 2003-11-20 Stryker Corp Osteogene Vorrichtungen
US4955893A (en) 1988-05-09 1990-09-11 Massachusetts Institute Of Technologh Prosthesis for promotion of nerve regeneration
US4950483A (en) * 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US5258029A (en) * 1988-09-29 1993-11-02 Collagen Corporation Method for improving implant fixation
US5849686A (en) 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof

Also Published As

Publication number Publication date
CA2082946C (en) 1996-12-10
US6605117B2 (en) 2003-08-12
US20020151985A1 (en) 2002-10-17
AU639574B2 (en) 1993-07-29
DE69115934T2 (de) 1996-05-23
US5645591A (en) 1997-07-08
DK0608211T3 (da) 1996-05-13
ATE132043T1 (de) 1996-01-15
US6468308B1 (en) 2002-10-22
JPH06505642A (ja) 1994-06-30
AU7961491A (en) 1991-12-31
JP2679409B2 (ja) 1997-11-19
US6077988A (en) 2000-06-20
ES2081484T3 (es) 1996-03-16
EP0608211A4 (de) 1993-06-15
EP0608211B1 (de) 1995-12-27
GR3019339T3 (en) 1996-06-30
EP0608211A1 (de) 1994-08-03
WO1991018558A1 (en) 1991-12-12

Similar Documents

Publication Publication Date Title
ATE132043T1 (de) Synthetische knochenbildungsschicht
Yannas et al. Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin.
AU4405285A (en) Collagenous Fibrous Tissue Implant
AU1466799A (en) Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials
DE68904132T2 (de) Verfahren zur herstellung von festen elastischen polymerpartikeln mit offenen poren.
EP0403650A4 (en) Medical material permitting cells to enter thereinto and artificial skin
DE68927153T2 (de) Biosynthetische osteogene proteine und sie enthaltende osteogene vorrichtungen
AU6634390A (en) Crosslinked polymer electrolyte and methods of making the same
AU589701B2 (en) Modified polymeric surfaces and process for preparing same
US5263985A (en) Bone growth stimulator
EP0206801A3 (de) Kollagen mit Gewebeaffinität für die Osteogenese und Verfahren zu seiner Herstellung
IL94128A (en) Nucleic acids encoding vascular endothelial cell growth factors, expression vectors and host cells comprising such nucleic acids and methods of producing such vascular endothelial growth factors
DE58909780D1 (de) Unter Verwendung von Alkenyl-phosphon- und -phosphinsäureester als Vernetzer hergestellte Hydrogele.
GR3019804T3 (en) Method for preparation of crosslinked polyamines
AU5864690A (en) Vascular prothesis containing in the wall microcapsules, including hormone-producing cells
EP0512122A4 (en) Implant material
CA2014542A1 (en) Medical implant and method for the manufacture thereof
ATE80406T1 (de) Biologisch aktive topische kollagentraegermatrix: kosmetische und pharmazeutische verwendung und verfahren zu deren herstellung.
DE69111245T2 (de) Knochenwachstumsstimulator.
EP0411124A4 (en) Medical material permitting cells to enter thereinto and artificial skin
DE59100964D1 (de) Verwendung von Zink-Calciumhydroxid, Lecithin und PAO zur Adjuvierung von Antigenlösungen und auf diese Weise adjuvierte Antigenlösungen.
ES544175A0 (es) Un procedimiento para preparar un material polimero hidrofilo basado en polisacaridos polipeptidos y -o proteinas y derivados acrilicos hidrofilos.
Yoshizato Collagen--Gelatin Composites as a New Biomaterial for Artificial Skin
Anderson 4840934 Therapeutic method using T cell growth factor
CA2235811A1 (en) Hybrid matrix implants and explants

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee