DE69118565T2 - Thiazolidinderivate mit antidiabetischer Wirkung, ihre Herstellung und Anwendung - Google Patents

Thiazolidinderivate mit antidiabetischer Wirkung, ihre Herstellung und Anwendung

Info

Publication number: DE69118565T2
Authority: DE; Germany
Prior art keywords: preparation; thiazolidine derivatives; hydrogen; diabetic effect; chem
Prior art date: 1990-02-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69118565T

Other languages

English (en)

Other versions

DE69118565D1 (de

Inventor

Takao Yoshioka

Takashi Fujita

Tsutomu Kanai

Kanichi Nakamura

Hiroyoshi Hirikoshi

Kunihiro Sasahara

Takeshi Kinoshita

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sankyo Co Ltd

Original Assignee

Sankyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-07

Filing date

1991-02-06

Publication date

1997-01-09

1991-02-06 Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd

1996-05-15 Application granted granted Critical

1996-05-15 Publication of DE69118565D1 publication Critical patent/DE69118565D1/de

1997-01-09 Publication of DE69118565T2 publication Critical patent/DE69118565T2/de

2011-02-07 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

230000003178 anti-diabetic effect Effects 0.000 title abstract 2
150000003548 thiazolidines Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
-1 methylene, carbonyl Chemical group 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

DE69118565T 1990-02-07 1991-02-06 Thiazolidinderivate mit antidiabetischer Wirkung, ihre Herstellung und Anwendung Expired - Fee Related DE69118565T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2802390		1990-02-07

Publications (2)

Publication Number	Publication Date
DE69118565D1 DE69118565D1 (de)	1996-05-15
DE69118565T2 true DE69118565T2 (de)	1997-01-09

Family

ID=12237153

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69118565T Expired - Fee Related DE69118565T2 (de)	1990-02-07	1991-02-06	Thiazolidinderivate mit antidiabetischer Wirkung, ihre Herstellung und Anwendung

Country Status (12)

Country	Link
US (1)	US5143930A (de)
EP (1)	EP0441605B1 (de)
KR (1)	KR0184601B1 (de)
AT (1)	ATE136544T1 (de)
AU (1)	AU637456B2 (de)
CA (1)	CA2035832C (de)
DE (1)	DE69118565T2 (de)
DK (1)	DK0441605T3 (de)
ES (1)	ES2088459T3 (de)
FI (1)	FI910583A (de)
GR (1)	GR3020196T3 (de)
HK (1)	HK1005451A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE93138T1 (de) *	1990-02-09	1993-09-15	Upjohn Co	Verwendung insulin-sensiblisierender wirkstoffe zur behandlung von hypertonie.
GB9124513D0 (en) *	1991-11-19	1992-01-08	Smithkline Beecham Plc	Novel process
NO302471B1 (no) *	1991-12-26	1998-03-09	Sankyo Co	Tiazolidinforbindelser og farmasöytisk preparat
NO302519B1 (no) *	1991-12-26	1998-03-16	Sankyo Co	Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat
ES2139633T3 (es)	1992-08-31	2000-02-16	Sankyo Co	Derivados de oxazolidina con propiedades anti-diabetica y anti-obesidad, su preparacion y su utilizacion terapeutica.
FR2696743B1 (fr) *	1992-10-12	1994-12-23	Adir	Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant.
JP3195455B2 (ja) *	1993-01-06	2001-08-06	ウェルファイド株式会社	キノリン−３−酢酸誘導体、その製造法と用途
TW268952B (de) *	1993-02-26	1996-01-21	Takeda Pharm Industry Co Ltd
CZ289317B6 (cs) *	1994-04-11	2002-01-16	Sankyo Company Limited	Heterocyklická sloučenina, farmaceutický prostředek ji obsahující a její pouľití
CA2159938A1 (en) *	1994-10-07	1996-04-08	Hiroaki Yanagisawa	Oxime derivatives, their preparation and their therapeutic use
IL118474A (en) *	1995-06-01	2001-08-08	Sankyo Co	Benzimideol derivatives and pharmaceutical preparations containing them
US5889025A (en) *	1996-05-06	1999-03-30	Reddy's Research Foundation	Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) *	1996-05-06	1999-07-06	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) *	1996-05-06	1998-09-01	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) *	1996-05-06	1997-12-02	Reddy Research Foundation	Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5885997A (en) *	1996-07-01	1999-03-23	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en)	1996-07-01	2002-04-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US6114526A (en) *	1996-07-01	2000-09-05	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) *	1996-07-01	2006-09-05	Dr. Reddy's Laboratories, Limited	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
CZ298812B6 (cs)	1996-07-01	2008-02-13	Dr. Reddy's Laboratories Limited	Azolidindionové deriváty, způsob jejich přípravy, farmaceutické kompozice s jejich obsahem a jejich použití v léčbě diabetu a příbuzných nemocí
EP1022272B1 (de)	1997-10-08	2004-05-26	Sankyo Company Limited	Substituierte kondensierte heterocyclische verbindungen
US6946295B2 (en) *	1998-06-12	2005-09-20	Cellfor, Inc.	Process for ex vitro sowing and germination of plant somatic embryos
US6028088A (en) *	1998-10-30	2000-02-22	The University Of Mississippi	Flavonoid derivatives
JP2004516279A (ja) *	2000-12-18	2004-06-03	スミスクライン・ビーチャム・コーポレイション	チアゾリジンジオン類
CA2783468C (en)	2009-12-15	2018-10-09	Metabolic Solutions Development Company, Llc	Ppar-sparing thiazolidinedione salts for the treatment of metabolic diseases
HUE030263T2 (en)	2010-04-19	2017-04-28	Octeta Therapeutics Llc	New synthesis for the preparation of thiazolidinedione compounds
PL2603498T3 (pl)	2010-08-10	2017-06-30	Octeta Therapeutics, Llc	Nowa synteza związków tiazolidynodionu
KR101857307B1 (ko) *	2010-08-10	2018-05-11	메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨	티아졸리딘디온 화합물의 합성법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en) *	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
JPS6051189A (ja) *	1983-08-30	1985-03-22	Sankyo Co Ltd	チアゾリジン誘導体およびその製造法
US4873255A (en) *	1987-02-04	1989-10-10	Sankyo Company Limited	Thiazolidinone derivatives, their preparation and their use
WO1989008650A1 (en) *	1988-03-08	1989-09-21	Pfizer Inc.	Thiazolidinedione hypoglycemic agents
US4933355A (en) *	1988-04-14	1990-06-12	Sankyo Company Limited	Thiazole derivatives, their preparation and their use in the treatment of diabetes complications
GB8919434D0 (en) *	1989-08-25	1989-10-11	Beecham Group Plc	Novel compounds

1991
- 1991-01-24 US US07/645,108 patent/US5143930A/en not_active Expired - Fee Related
- 1991-02-06 CA CA002035832A patent/CA2035832C/en not_active Expired - Fee Related
- 1991-02-06 AT AT91300959T patent/ATE136544T1/de not_active IP Right Cessation
- 1991-02-06 EP EP91300959A patent/EP0441605B1/de not_active Expired - Lifetime
- 1991-02-06 ES ES91300959T patent/ES2088459T3/es not_active Expired - Lifetime
- 1991-02-06 DE DE69118565T patent/DE69118565T2/de not_active Expired - Fee Related
- 1991-02-06 DK DK91300959.3T patent/DK0441605T3/da active
- 1991-02-07 KR KR1019910002101A patent/KR0184601B1/ko not_active IP Right Cessation
- 1991-02-07 FI FI910583A patent/FI910583A/fi unknown
- 1991-02-07 AU AU70906/91A patent/AU637456B2/en not_active Ceased
1996
- 1996-06-12 GR GR960401562T patent/GR3020196T3/el unknown
1998
- 1998-05-27 HK HK98104570A patent/HK1005451A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0441605A2 (de)	1991-08-14
EP0441605A3 (en)	1992-01-22
AU637456B2 (en)	1993-05-27
DK0441605T3 (da)	1996-07-29
FI910583A (fi)	1991-08-08
CA2035832C (en)	2000-08-29
KR0184601B1 (ko)	1999-05-01
EP0441605B1 (de)	1996-04-10
GR3020196T3 (en)	1996-09-30
US5143930A (en)	1992-09-01
FI910583A0 (fi)	1991-02-07
HK1005451A1 (en)	1999-01-08
CA2035832A1 (en)	1991-08-08
AU7090691A (en)	1991-08-08
DE69118565D1 (de)	1996-05-15
ES2088459T3 (es)	1996-08-16
ATE136544T1 (de)	1996-04-15
KR910015552A (ko)	1991-09-30

Legal Events

Date	Code	Title	Description
1997-05-07	8364	No opposition during term of opposition
2002-12-19	8339	Ceased/non-payment of the annual fee

Publication	Publication Date	Title
DE69118565T2 (de)	1997-01-09	Thiazolidinderivate mit antidiabetischer Wirkung, ihre Herstellung und Anwendung
NO905572L (no)	1991-06-24	Fremgangsmaate for fremstilling av peptidforbindelser.
KR890000485A (ko)	1989-03-15	캠프토데신 유도체 및 그의 아미노기에 있어서의 산 부가염 및 4급 암모늄염 및 그의 제조방법
WO1998035951A3 (en)	1998-11-12	New aminopiperazine derivatives
DE69222459T2 (de)	1998-02-05	Thiazolidindionderivate, ihre Herstellung und Anwendung
DE69204041T2 (de)	1996-03-28	Thiazolidinverbindeungen, deren Herstellung und therapeutische Verwendung.
SE8406141L (sv)	1985-12-13	N-acylaminosyradiamidderivat, salter derav, forfarande for deras framstellning och antiulcermedel innehallande dessa
FI931346A (fi)	1993-09-27	Butadienderivat och foerfarande foer deras framstaellning
FI881104A0 (fi)	1988-03-09	Menetelmä antidiabeettisina aineina käytettävien bentsoksatsiinijohdannaisten valmistamiseksi
IE872234L (en)	1988-02-21	Derivatives of indane
HUT57833A (en)	1991-12-30	Process for producing new macrolide compounds and pharmaceutical compositions comprising same as active ingredient
IE862707L (en)	1987-04-15	Dichloroaniline derivatives
ATE236162T1 (de)	2003-04-15	Pyrroloazepinderivate
IE890259L (en)	1989-08-28	Macrolide compounds
DE3873170T2 (de)	1992-12-03	Verwendung von -7-thiaprostaglandin e1 oder seinen derivaten zur herstellung eines antidiabetikums.
FI20021652A (fi)	2002-09-16	Tratsodonin alkyylijohdannaisten valmistuksessa käyttökelpoisia välituotteita
ATE112682T1 (de)	1994-10-15	Isocarbacyclinderivate enthaltende antidiabetika.
SE8703068L (sv)	1988-02-08	Komposition for att inducera och stimulera hartillvext och minska haravfall baserad pa pyrimidinderivat
ATE129246T1 (de)	1995-11-15	Pyrazolo(1,5-a)pyridine, deren herstellung und verwendung.
FI841207A (fi)	1984-10-01	Troponderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutisk komposition.
SE9201188L (sv)	1993-10-15	Ny användning
FI841611A0 (fi)	1984-04-24	1,3-bis(dimetylamino)-2-propyl-4- klorofenoxiacetat, foerfarande foer framstaellning av detta och denna foeren foerening innehaollande laekemedelspreparat.