DE69132175T2 - Nicht-invasives Verfahren zum Erhalt von Materialien durch die Haut - Google Patents

Nicht-invasives Verfahren zum Erhalt von Materialien durch die Haut

Info

Publication number
DE69132175T2
DE69132175T2 DE69132175T DE69132175T DE69132175T2 DE 69132175 T2 DE69132175 T2 DE 69132175T2 DE 69132175 T DE69132175 T DE 69132175T DE 69132175 T DE69132175 T DE 69132175T DE 69132175 T2 DE69132175 T2 DE 69132175T2
Authority
DE
Germany
Prior art keywords
skin
invasive procedure
obtaining materials
sample
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69132175T
Other languages
English (en)
Other versions
DE69132175D1 (de
Inventor
Durairaj Bommannan
Hiroshia Okuyama
Richard Henry Guy
Paul Stauffer
Gordon L Flynn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Animas Technologies LLC
Original Assignee
University of California
Cygnus Therapeutic Systems
Cygnus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California, Cygnus Therapeutic Systems, Cygnus Inc filed Critical University of California
Publication of DE69132175D1 publication Critical patent/DE69132175D1/de
Application granted granted Critical
Publication of DE69132175T2 publication Critical patent/DE69132175T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
DE69132175T 1990-02-23 1991-02-21 Nicht-invasives Verfahren zum Erhalt von Materialien durch die Haut Expired - Fee Related DE69132175T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/484,560 US5115805A (en) 1990-02-23 1990-02-23 Ultrasound-enhanced delivery of materials into and through the skin

Publications (2)

Publication Number Publication Date
DE69132175D1 DE69132175D1 (de) 2000-06-08
DE69132175T2 true DE69132175T2 (de) 2000-09-28

Family

ID=23924657

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69124365T Expired - Fee Related DE69124365T2 (de) 1990-02-23 1991-02-21 Mittels ultraschall gesteigerte verabreichung von materialien durch die haut
DE69132175T Expired - Fee Related DE69132175T2 (de) 1990-02-23 1991-02-21 Nicht-invasives Verfahren zum Erhalt von Materialien durch die Haut

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69124365T Expired - Fee Related DE69124365T2 (de) 1990-02-23 1991-02-21 Mittels ultraschall gesteigerte verabreichung von materialien durch die haut

Country Status (15)

Country Link
US (3) US5115805A (de)
EP (2) EP0515566B1 (de)
JP (1) JP2695986B2 (de)
AT (2) ATE192344T1 (de)
AU (1) AU656519B2 (de)
CA (1) CA2075624C (de)
DE (2) DE69124365T2 (de)
DK (1) DK0736305T3 (de)
ES (2) ES2097206T3 (de)
FI (1) FI923743A (de)
GR (1) GR3034087T3 (de)
IE (1) IE910613A1 (de)
NZ (1) NZ237197A (de)
PT (1) PT96856A (de)
WO (1) WO1991012772A1 (de)

Families Citing this family (189)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956032B1 (en) 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5679399A (en) * 1987-07-17 1997-10-21 Bio Barrier, Inc. Method of forming a membrane, especially a latex or polymer membrane, including multiple discrete layers
US5549924A (en) * 1987-07-17 1996-08-27 Robin Renee Thill Shlenker Method of forming a membrane, especially a latex or polymer membrane, including a deactivating barrier and indicating layer
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5231975A (en) * 1990-02-23 1993-08-03 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
SE469778B (sv) * 1992-02-17 1993-09-13 Bertil Olsson Enheten Foer Kar Apparat för arteriell reperfusion genom noninvasiv ultraljudspåverkan
JPH0670987A (ja) * 1992-08-28 1994-03-15 Katsuro Tachibana 薬物投与・体液採取ユニット及び装置
US5421816A (en) * 1992-10-14 1995-06-06 Endodermic Medical Technologies Company Ultrasonic transdermal drug delivery system
SE9301171D0 (sv) * 1993-04-07 1993-04-07 Ab Astra Pharmaceutical composition containing lipophilic drugs
US5667487A (en) * 1993-04-07 1997-09-16 Henley; Julian L. Ionosonic drug delivery apparatus
JP3415203B2 (ja) * 1993-07-12 2003-06-09 立花 克郎 治療用超音波発生装置
US5415629A (en) * 1993-09-15 1995-05-16 Henley; Julian L. Programmable apparatus for the transdermal delivery of drugs and method
US6056738A (en) * 1997-01-31 2000-05-02 Transmedica International, Inc. Interstitial fluid monitoring
US5814599A (en) * 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5836940A (en) * 1994-10-25 1998-11-17 Latis, Inc. Photoacoustic drug delivery
US5817144A (en) * 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US5861431A (en) * 1995-06-07 1999-01-19 Iotek, Inc. Incontinence treatment
US6002961A (en) * 1995-07-25 1999-12-14 Massachusetts Institute Of Technology Transdermal protein delivery using low-frequency sonophoresis
US5947921A (en) * 1995-12-18 1999-09-07 Massachusetts Institute Of Technology Chemical and physical enhancers and ultrasound for transdermal drug delivery
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
EP0781150B1 (de) * 1995-07-25 2002-11-06 Massachusetts Institute Of Technology Verbesserter transdermaler transport unter verwendung von ultraschall
TR199800347T1 (xx) * 1995-08-29 1998-05-21 Spectrx, Inc. �la� uygulamas� i�in insan derisinin mikro-g�zeneklendirilmesi ve uygulamalar�n g�zlemlenmesi.
US5618275A (en) * 1995-10-27 1997-04-08 Sonex International Corporation Ultrasonic method and apparatus for cosmetic and dermatological applications
WO1997022325A1 (en) * 1995-12-20 1997-06-26 Sonex International Corporation Sonic method and apparatus for cosmetic applications
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US7094422B2 (en) 1996-02-19 2006-08-22 Acrux Dds Pty Ltd. Topical delivery of antifungal agents
US5895362A (en) * 1996-02-23 1999-04-20 Abbott Laboratories Transdermal transport using ultrasonic standing waves
US6009343A (en) * 1996-02-23 1999-12-28 Abbott Laboratories Enhanced transdermal transport of fluid using vacuum
JP2002515786A (ja) * 1996-06-28 2002-05-28 ソントラ メディカル，エル．ピー． 経皮輸送の超音波増強
DE69722414T2 (de) 1996-07-03 2004-05-19 Altea Therapeutics Corp. Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US5911223A (en) * 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US6024717A (en) * 1996-10-24 2000-02-15 Vibrx, Inc. Apparatus and method for sonically enhanced drug delivery
EP0957980A4 (de) * 1996-11-27 2000-03-29 Gen Hospital Corp Abgabe von verbindungen mittels transient-impulsen
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
DK1314400T3 (da) * 1996-12-31 2007-10-15 Altea Therapeutics Corp Mikroporering af væv til levering af bioaktive midler
US7789841B2 (en) 1997-02-06 2010-09-07 Exogen, Inc. Method and apparatus for connective tissue treatment
US5913833A (en) * 1997-02-07 1999-06-22 Abbott Laboratories Method and apparatus for obtaining biological fluids
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
US6723063B1 (en) * 1998-06-29 2004-04-20 Ekos Corporation Sheath for use with an ultrasound element
WO1998048711A1 (en) * 1997-05-01 1998-11-05 Ekos Corporation Ultrasound catheter
US6676626B1 (en) * 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6085115A (en) * 1997-05-22 2000-07-04 Massachusetts Institite Of Technology Biopotential measurement including electroporation of tissue surface
JP4441000B2 (ja) * 1997-06-23 2010-03-24 克郎 立花 生体組織処理装置
US5954675A (en) * 1997-07-07 1999-09-21 Dellagatta; Enrico Michael Method of ultrasonic therapy
US20060184071A1 (en) * 1997-12-29 2006-08-17 Julia Therapeutics, Llc Treatment of skin with acoustic energy
US6575956B1 (en) * 1997-12-31 2003-06-10 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
WO1999034857A1 (en) 1998-01-08 1999-07-15 Sontra Medical, Inc. Sonophoretic enhanced transdermal transport
US8287483B2 (en) * 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US7066884B2 (en) 1998-01-08 2006-06-27 Sontra Medical, Inc. System, method, and device for non-invasive body fluid sampling and analysis
US20060015058A1 (en) * 1998-01-08 2006-01-19 Kellogg Scott C Agents and methods for enhancement of transdermal transport
US7273458B2 (en) 1998-01-12 2007-09-25 Georgia Tech Research Corporation Method of applying acoustic energy effective to alter transport or cell viability
US20020055702A1 (en) * 1998-02-10 2002-05-09 Anthony Atala Ultrasound-mediated drug delivery
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6587705B1 (en) 1998-03-13 2003-07-01 Lynn Kim Biosensor, iontophoretic sampling system, and methods of use thereof
US6030374A (en) * 1998-05-29 2000-02-29 Mcdaniel; David H. Ultrasound enhancement of percutaneous drug absorption
AU3209299A (en) * 1998-04-03 1999-10-25 David H. Mcdaniel Ultrasound enhancement of percutaneous drug absorption
US6066123A (en) * 1998-04-09 2000-05-23 The Board Of Trustees Of The Leland Stanford Junior University Enhancement of bioavailability by use of focused energy delivery to a target tissue
CA2338735A1 (en) 1998-07-21 2000-02-03 Acoustic Sciences Associates Synthetic structural imaging and volume estimation of biological tissue organs
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
CA2342801A1 (en) 1998-09-04 2000-03-16 Powderject Research Limited Monitoring methods using particle delivery methods
US6148231A (en) * 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
ATE254877T1 (de) 1998-09-17 2003-12-15 Cygnus Therapeutic Systems Gerät zum zusammendrücken einer gel/sensor- einheit
US6312402B1 (en) 1998-09-24 2001-11-06 Ekos Corporation Ultrasound catheter for improving blood flow to the heart
US6180416B1 (en) 1998-09-30 2001-01-30 Cygnus, Inc. Method and device for predicting physiological values
DE69908602T2 (de) 1998-09-30 2004-06-03 Cygnus, Inc., Redwood City Verfahren und vorrichtung zum vorhersagen von physiologischen messwerten
US6391643B1 (en) 1998-10-28 2002-05-21 Cygnus, Inc. Kit and method for quality control testing of an iontophoretic sampling system
DE19850517B4 (de) * 1998-11-03 2004-02-12 Lts Lohmann Therapie-Systeme Ag Verwendung eines wirkstoffhaltigen transdermalen therapeutischen Systems in einer Kombinationsbehandlung mit und ohne Ultraschall
US6887260B1 (en) 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US20060212025A1 (en) * 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US6936044B2 (en) * 1998-11-30 2005-08-30 Light Bioscience, Llc Method and apparatus for the stimulation of hair growth
US6283956B1 (en) * 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
US6231528B1 (en) * 1999-01-15 2001-05-15 Jonathan J. Kaufman Ultrasonic and growth factor bone-therapy: apparatus and method
EP1135052A1 (de) 1999-02-12 2001-09-26 Cygnus, Inc. Gerät und verfahren zur häufigen messung von analyten anwesend im biologischen system
US6792306B2 (en) * 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US6477410B1 (en) * 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US7127285B2 (en) * 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
FR2791249B1 (fr) * 1999-03-25 2001-06-15 Edap Technomed Milieu de couplage pour ultrasons de puissance
ATE290902T1 (de) 1999-04-16 2005-04-15 Johnson & Johnson Consumer Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren
CA2369336A1 (en) 1999-04-22 2000-11-02 Cygnus, Inc. Hydrogel in an iontophoretic device to measure glucose
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
CA2375643C (en) 1999-07-08 2009-01-27 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US20030229331A1 (en) * 1999-11-05 2003-12-11 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6885883B2 (en) * 2000-05-16 2005-04-26 Cygnus, Inc. Methods for improving performance and reliability of biosensors
US6540675B2 (en) * 2000-06-27 2003-04-01 Rosedale Medical, Inc. Analyte monitor
US6553244B2 (en) 2000-08-18 2003-04-22 Cygnus, Inc. Analyte monitoring device alarm augmentation system
WO2002015777A1 (en) 2000-08-18 2002-02-28 Cygnus, Inc. Methods and devices for prediction of hypoglycemic events
AU2001288388A1 (en) * 2000-08-24 2002-03-04 Encapsulation Systems, Inc. Substance delivery system
US6964647B1 (en) 2000-10-06 2005-11-15 Ellaz Babaev Nozzle for ultrasound wound treatment
US6487447B1 (en) * 2000-10-17 2002-11-26 Ultra-Sonic Technologies, L.L.C. Method and apparatus for in-vivo transdermal and/or intradermal delivery of drugs by sonoporation
US6601581B1 (en) 2000-11-01 2003-08-05 Advanced Medical Applications, Inc. Method and device for ultrasound drug delivery
US6533803B2 (en) 2000-12-22 2003-03-18 Advanced Medical Applications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US6761729B2 (en) 2000-12-22 2004-07-13 Advanced Medicalapplications, Inc. Wound treatment method and device with combination of ultrasound and laser energy
US7914470B2 (en) * 2001-01-12 2011-03-29 Celleration, Inc. Ultrasonic method and device for wound treatment
US8235919B2 (en) 2001-01-12 2012-08-07 Celleration, Inc. Ultrasonic method and device for wound treatment
US6960173B2 (en) * 2001-01-30 2005-11-01 Eilaz Babaev Ultrasound wound treatment method and device using standing waves
US6623444B2 (en) 2001-03-21 2003-09-23 Advanced Medical Applications, Inc. Ultrasonic catheter drug delivery method and device
US6478754B1 (en) 2001-04-23 2002-11-12 Advanced Medical Applications, Inc. Ultrasonic method and device for wound treatment
US6503209B2 (en) 2001-05-18 2003-01-07 Said I. Hakky Non-invasive focused energy blood withdrawal and analysis system
NZ512367A (en) * 2001-06-14 2005-05-27 Horticulture & Food Res Inst Non-invasive transudate extraction
WO2003000127A2 (en) * 2001-06-22 2003-01-03 Cygnus, Inc. Method for improving the performance of an analyte monitoring system
US6908448B2 (en) * 2001-08-24 2005-06-21 Dermisonics, Inc. Substance delivery device
US20050075599A1 (en) * 2001-08-24 2005-04-07 Redding Bruce K. Ultrasonically enhanced saline treatment for burn damaged skin
US6795727B2 (en) 2001-10-17 2004-09-21 Pedro Giammarusti Devices and methods for promoting transcutaneous movement of substances
AU2002359576A1 (en) 2001-12-03 2003-06-17 Ekos Corporation Catheter with multiple ultrasound radiating members
EP1465529A4 (de) * 2002-01-15 2005-04-20 Bruce K Redding Jr Tragbarer, portabler schallapplikator zur freisetzung bioaktiver verbindungen von internen organen
TWI220386B (en) 2002-01-21 2004-08-21 Matsushita Electric Works Ltd Ultrasonic transdermal permeation device
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
CA2478822C (en) 2002-03-11 2016-07-12 Altea Therapeutics Corporation Transdermal drug delivery patch system, method of making same and method of using same
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
DE60334365D1 (de) 2002-03-22 2010-11-11 Animas Technologies Llc Leistungsverbesserung einer analytenüberwachungsvorrichtung
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US6801041B2 (en) * 2002-05-14 2004-10-05 Abbott Laboratories Sensor having electrode for determining the rate of flow of a fluid
JP4243499B2 (ja) * 2002-06-11 2009-03-25 富士通株式会社 貼合せ基板製造装置及び貼合せ基板製造方法
US20030233085A1 (en) 2002-06-18 2003-12-18 Pedro Giammarusti Optimization of transcutaneous active permeation of compounds through the synergistic use of ultrasonically generated mechanical abrasion of the skin, chemical enhancers and simultaneous application of sonophoresis, iontophoresis, electroporation, mechanical vibrations and magnetophoresis through single application devices
US7099713B2 (en) 2002-06-28 2006-08-29 Battelle Memorial Institute Skin conduction and transport systems
US7150975B2 (en) 2002-08-19 2006-12-19 Animas Technologies, Llc Hydrogel composition for measuring glucose flux
ATE359802T1 (de) * 2002-10-04 2007-05-15 Photokinetix Inc Photokinetische abgabe von biologisch aktiven subtanzen unter verwendung von pulsierendem inkohaerentem licht.
JP4713339B2 (ja) 2002-10-10 2011-06-29 ビジュアルソニックス インコーポレイティド 高周波数高フレームレート超音波撮像システム
US6921371B2 (en) 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
US6860852B2 (en) * 2002-10-25 2005-03-01 Compex Medical S.A. Ultrasound therapeutic device
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
KR20060041161A (ko) * 2003-04-10 2006-05-11 라이트 바이오사이언스, 엘엘씨 세포 증식 및 유전자 발현의 조절을 위한 광조절 방법 및광조절 장치
JP2004343275A (ja) * 2003-05-14 2004-12-02 Murata Mach Ltd 画像処理システム及びスキャナ装置
EP1663381B1 (de) 2003-06-13 2010-05-19 The Procter & Gamble Company Sonophorese-hautpflegevorrichtung
KR101160343B1 (ko) * 2003-07-31 2012-06-26 젠틀웨이브즈 엘엘씨. 화상, 상처 및 관련 피부 질환의 광역학적 치료 장치 및방법
US20050069925A1 (en) 2003-08-15 2005-03-31 Russell Ford Microprocessors, devices, and methods for use in monitoring of physiological analytes
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
US20050137520A1 (en) * 2003-10-29 2005-06-23 Rule Peter R. Catheter with ultrasound-controllable porous membrane
US20050148833A1 (en) * 2003-12-24 2005-07-07 Gregory Skover Apparatus containing a sensing element for the treatment of skin
US20060058708A1 (en) * 2003-12-24 2006-03-16 Gill Heart Method and apparatus for ultrasonically increasing the transportation of therapeutic substances through tissue
EP1786331A2 (de) * 2004-07-15 2007-05-23 Freedom-2, LLC Modifiziertes gewebemarkierungspigment und modifizierungsverfahren für gewebemarkierungspigment
GB0422525D0 (en) 2004-10-11 2004-11-10 Luebcke Peter Dermatological compositions and methods
US20060094945A1 (en) * 2004-10-28 2006-05-04 Sontra Medical Corporation System and method for analyte sampling and analysis
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US7785277B2 (en) * 2005-06-23 2010-08-31 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
US7713218B2 (en) 2005-06-23 2010-05-11 Celleration, Inc. Removable applicator nozzle for ultrasound wound therapy device
EP1928304B1 (de) 2005-09-30 2012-10-24 Intuity Medical, Inc. Katalysatoren für körperflüssigkeitsprobennahme
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US7432069B2 (en) * 2005-12-05 2008-10-07 Sontra Medical Corporation Biocompatible chemically crosslinked hydrogels for glucose sensing
EP1963832A2 (de) * 2005-12-16 2008-09-03 Bayer Healthcare, LLC Doppelsensorenanordnung zur transdermalen analyse und verfahren zu ihrer anwendung
WO2007081750A2 (en) * 2006-01-06 2007-07-19 The Curators Of The University Of Missouri Ultrasound-mediated transcleral drug delivery
US20080031833A1 (en) * 2006-03-13 2008-02-07 Oblong John E Combined energy and topical composition application for regulating the condition of mammalian skin
US7662177B2 (en) * 2006-04-12 2010-02-16 Bacoustics, Llc Apparatus and methods for pain relief using ultrasound waves in combination with cryogenic energy
US7431704B2 (en) 2006-06-07 2008-10-07 Bacoustics, Llc Apparatus and method for the treatment of tissue with ultrasound energy by direct contact
US20080183200A1 (en) * 2006-06-07 2008-07-31 Bacoustics Llc Method of selective and contained ultrasound debridement
US8562547B2 (en) * 2006-06-07 2013-10-22 Eliaz Babaev Method for debriding wounds
NZ594136A (en) * 2006-06-15 2013-03-28 Seagull Ip Pty Ltd Delivery of bound material from body to surface using ultrasonic signal
AU2014200299B2 (en) * 2006-06-15 2015-04-02 Polypharma Pty Ltd A delivery system and process
US8192363B2 (en) 2006-10-27 2012-06-05 Ekos Corporation Catheter with multiple ultrasound radiating members
US20080152592A1 (en) * 2006-12-21 2008-06-26 Bayer Healthcare Llc Method of therapeutic drug monitoring
US20080177221A1 (en) * 2006-12-22 2008-07-24 Celleration, Inc. Apparatus to prevent applicator re-use
US20080214965A1 (en) * 2007-01-04 2008-09-04 Celleration, Inc. Removable multi-channel applicator nozzle
US8491521B2 (en) * 2007-01-04 2013-07-23 Celleration, Inc. Removable multi-channel applicator nozzle
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US8812071B2 (en) * 2007-03-07 2014-08-19 Echo Therapeutics, Inc. Transdermal analyte monitoring systems and methods for analyte detection
US20100210932A1 (en) * 2007-03-20 2010-08-19 Bayer Healthcare Llc Method of analyzing an analyte
US8386027B2 (en) * 2007-04-27 2013-02-26 Echo Therapeutics, Inc. Skin permeation device for analyte sensing or transdermal drug delivery
US9044568B2 (en) 2007-06-22 2015-06-02 Ekos Corporation Method and apparatus for treatment of intracranial hemorrhages
WO2009079415A1 (en) * 2007-12-14 2009-06-25 Ekos Corporation Ultrasound pulse shaping
EP2231279A1 (de) * 2007-12-28 2010-09-29 Celleration, Inc. Verfahren zur behandlung von entzündlichen hauterkrankungen
WO2009145920A1 (en) 2008-05-30 2009-12-03 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
EP2299904B1 (de) 2008-06-06 2019-09-11 Intuity Medical, Inc. Medizinisches messverfahren
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US20100022919A1 (en) * 2008-07-22 2010-01-28 Celleration, Inc. Methods of Skin Grafting Using Ultrasound
EP3106871B1 (de) 2009-11-30 2021-10-27 Intuity Medical, Inc. Verfahren zum verifizieren der genauigkeit des betriebs einer analyt-überwachungsvorrichtung
CA2796575C (en) 2010-04-13 2018-05-15 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use
CA2803797A1 (en) 2010-06-25 2011-12-29 Intuity Medical, Inc. Analyte monitoring methods and systems
WO2012129545A1 (en) 2011-03-23 2012-09-27 Redding Bruce K Systems and methods for enhancing the delivery of compounds to skin pores using ultrasonic waveforms
US11458290B2 (en) 2011-05-11 2022-10-04 Ekos Corporation Ultrasound system
ITGE20110067A1 (it) * 2011-06-30 2012-12-31 Esaote Spa Dispositivo per il rilevamento di immagini ad ultrasuoni
EP3407064B1 (de) 2011-08-03 2020-04-22 Intuity Medical, Inc. Vorrichtung zur entnahme von körperflüssigkeiten
US10729386B2 (en) 2013-06-21 2020-08-04 Intuity Medical, Inc. Analyte monitoring system with audible feedback
AU2014355072A1 (en) 2013-11-26 2016-06-02 Alliqua Biomedical, Inc. Systems and methods for producing and delivering ultrasonic therapies for wound treatment and healing
US10092742B2 (en) 2014-09-22 2018-10-09 Ekos Corporation Catheter system
EP3307388B1 (de) 2015-06-10 2022-06-22 Ekos Corporation Ultraschallkatheter
WO2018185767A1 (en) * 2017-04-03 2018-10-11 Mdsg Innovation Ltd. Apparatus and method for treating kidneys

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6409245A (de) * 1964-06-17 1966-02-14
US3710779A (en) * 1970-01-16 1973-01-16 Hoffmann La Roche Method of ultrasonic coupling
US4002221A (en) * 1972-09-19 1977-01-11 Gilbert Buchalter Method of transmitting ultrasonic impulses to surface using transducer coupling agent
US3941122A (en) * 1974-04-08 1976-03-02 Bolt Beranek And Newman, Inc. High frequency ultrasonic process and apparatus for selectively dissolving and removing unwanted solid and semi-solid materials and the like
GB1577551A (en) * 1976-02-09 1980-10-22 Fahim M Medication for topical application by ultrasound
US4309989A (en) * 1976-02-09 1982-01-12 The Curators Of The University Of Missouri Topical application of medication by ultrasound with coupling agent
DE2756460A1 (de) * 1977-12-17 1979-06-21 Fraunhofer Ges Forschung Verfahren zur lokal begrenzten applikation von therpeutika durch die oberflaeche von lebenden koerpern oder koerperorganen
SU799750A1 (ru) * 1978-05-03 1981-01-30 Сочинский Научно-Исследовательс-Кий Институт Курортологии И Физи-Отерапии Способ лечени больных дегене-РАТиВНО-диСТРОфичЕСКиМи зАбОлЕВА-Ни Ми пОзВОНОчНиКА
SU770496A1 (ru) * 1978-12-29 1980-10-15 Mo Vysshee Tekhnicheskoe Uchil Способ стерилизации биологических тканей 1
SU878268A1 (ru) * 1979-11-19 1981-11-07 Московское Ордена Ленина И Ордена Трудового Красного Знамени Высшее Техническое Училище Им. Н.Э.Баумана Способ лечени инфицированных ран
SU884700A1 (ru) * 1980-03-10 1981-11-30 Ордена Трудового Красного Знамени Институт Медицинской Паразитологии И Тропической Медицины Им.Е.И.Марциновского Способ лечени глубоких микозов
US4372296A (en) * 1980-11-26 1983-02-08 Fahim Mostafa S Treatment of acne and skin disorders and compositions therefor
US4484569A (en) * 1981-03-13 1984-11-27 Riverside Research Institute Ultrasonic diagnostic and therapeutic transducer assembly and method for using
SU1111759A1 (ru) * 1981-12-16 1984-09-07 Белорусский Государственный Научно-Исследовательский Институт Неврологии,Нейрохирургии И Физиотерапии Способ лечени импотенции у больных с хронической окклюзией брюшной аорты
SU1153917A1 (ru) * 1983-03-05 1985-05-07 Киевский государственный институт усовершенствования врачей Способ лечени кохлеарного неврита
SU1142121A1 (ru) * 1983-03-05 1985-02-28 Киевский государственный институт усовершенствования врачей Способ лечени отомикозов
US5158070A (en) * 1983-12-14 1992-10-27 Edap International, S.A. Method for the localized destruction of soft structures using negative pressure elastic waves
CA1237482A (en) * 1984-03-09 1988-05-31 Frank B. Stiles Catheter for effecting removal of obstructions from a biological duct
SU1286201A1 (ru) * 1984-04-10 1987-01-30 Саратовский научно-исследовательский институт травматологии и ортопедии Способ лечени травматических повреждений суставов
SU1181664A1 (ru) * 1984-05-21 1985-09-30 Киевский государственный институт усовершенствования врачей Способ лечени фурункула носа
FR2584916B1 (fr) * 1985-07-19 1990-05-25 Satelec Soc Appareil de curetage ou d'exerese de tissus biologiques par un instrument vibrant a des frequences ultrasonores
FR2587893B1 (fr) * 1985-09-27 1990-03-09 Dory Jacques Procede et dispositif de reperage permettant, au cours d'une lithotripsie, d'apprecier le degre de fragmentation des calculs
SU1512607A1 (ru) * 1986-06-27 1989-10-07 Научно-Исследовательский Институт Курортологии И Физиотерапии Им.А.А.Акопяна Способ лечени гипертонической болезни 1Б-11А стадии
US4767402A (en) * 1986-07-08 1988-08-30 Massachusetts Institute Of Technology Ultrasound enhancement of transdermal drug delivery
US4791915A (en) * 1986-09-29 1988-12-20 Dynawave Corporation Ultrasound therapy device
JPS63135179A (ja) * 1986-11-26 1988-06-07 立花　俊郎 薬物の経皮投与具
US4787888A (en) * 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US4780212A (en) * 1987-07-31 1988-10-25 Massachusetts Institute Of Technology Ultrasound enchancement of membrane permeability
DE3736072A1 (de) * 1987-09-24 1989-04-13 Soft Electrics & Cosmetics Ver Verfahren und geraet zur foerderung des wohlbefindens des menschen und zur kosmetischen behandlung der haut
WO1989006989A1 (en) * 1988-01-29 1989-08-10 The Regents Of The University Of California Iontophoretic non-invasive sampling or delivery device
US5143063A (en) * 1988-02-09 1992-09-01 Fellner Donald G Method of removing adipose tissue from the body
US5016615A (en) * 1990-02-20 1991-05-21 Riverside Research Institute Local application of medication with ultrasound
US5115805A (en) * 1990-02-23 1992-05-26 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin
US5231975A (en) * 1990-02-23 1993-08-03 Cygnus Therapeutic Systems Ultrasound-enhanced delivery of materials into and through the skin

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CA2075624C (en) 1997-11-18
EP0515566A1 (de) 1992-12-02
IE910613A1 (en) 1991-08-28
JP2695986B2 (ja) 1998-01-14
DE69132175D1 (de) 2000-06-08
DE69124365D1 (de) 1997-03-06
AU656519B2 (en) 1995-02-09
ATE192344T1 (de) 2000-05-15
PT96856A (pt) 1991-11-29
US5636632A (en) 1997-06-10
ES2146339T3 (es) 2000-08-01
JPH06501855A (ja) 1994-03-03
AU7488391A (en) 1991-09-18
FI923743A0 (fi) 1992-08-20
ES2097206T3 (es) 1997-04-01
EP0736305A3 (de) 1998-08-19
GR3034087T3 (en) 2000-11-30
US5323769A (en) 1994-06-28
EP0736305A2 (de) 1996-10-09
FI923743A (fi) 1992-08-20
NZ237197A (en) 1997-04-24
EP0515566A4 (en) 1993-02-03
DK0736305T3 (da) 2000-12-04
ATE148001T1 (de) 1997-02-15
US5115805A (en) 1992-05-26
WO1991012772A1 (en) 1991-09-05
EP0736305B1 (de) 2000-05-03
DE69124365T2 (de) 1997-05-28
EP0515566B1 (de) 1997-01-22
CA2075624A1 (en) 1991-08-24

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