DE69132657D1 - Bioabbaubare partikelumhüllungen mit einem durch ein vernetzungsagens immobilisierten protein - Google Patents
Bioabbaubare partikelumhüllungen mit einem durch ein vernetzungsagens immobilisierten proteinInfo
- Publication number
- DE69132657D1 DE69132657D1 DE69132657T DE69132657T DE69132657D1 DE 69132657 D1 DE69132657 D1 DE 69132657D1 DE 69132657 T DE69132657 T DE 69132657T DE 69132657 T DE69132657 T DE 69132657T DE 69132657 D1 DE69132657 D1 DE 69132657D1
- Authority
- DE
- Germany
- Prior art keywords
- bio
- protein immobilized
- networking agent
- degradable particle
- particle packages
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/005—Pretreatment specially adapted for magnetic separation
- B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/5434—Magnetic particles using magnetic particle immunoreagent carriers which constitute new materials per se
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
- G01N2446/84—Polymer coating, e.g. gelatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
- G01N2446/86—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids the coating being pre-functionalised for attaching immunoreagents, e.g. aminodextran
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2446/00—Magnetic particle immunoreagent carriers
- G01N2446/80—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids
- G01N2446/90—Magnetic particle immunoreagent carriers characterised by the agent used to coat the magnetic particles, e.g. lipids characterised by small molecule linker used to couple immunoreagents to magnetic particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2991—Coated
- Y10T428/2998—Coated including synthetic resin or polymer
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/607,253 US5169754A (en) | 1990-10-31 | 1990-10-31 | Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same |
PCT/US1991/007911 WO1992008134A1 (en) | 1990-10-31 | 1991-10-25 | Biodegradable particle coatings having a protein covalently immobilized by a crosslinking agent |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69132657D1 true DE69132657D1 (de) | 2001-08-16 |
DE69132657T2 DE69132657T2 (de) | 2002-06-20 |
Family
ID=24431478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69132657T Expired - Fee Related DE69132657T2 (de) | 1990-10-31 | 1991-10-25 | Bioabbaubare partikelumhüllungen mit einem durch ein vernetzungsagens immobilisierten protein |
Country Status (7)
Country | Link |
---|---|
US (1) | US5169754A (de) |
EP (1) | EP0556346B1 (de) |
JP (1) | JP3297046B2 (de) |
AU (1) | AU665730B2 (de) |
CA (1) | CA2095148A1 (de) |
DE (1) | DE69132657T2 (de) |
WO (1) | WO1992008134A1 (de) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5294369A (en) * | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
US5248772A (en) * | 1992-01-29 | 1993-09-28 | Coulter Corporation | Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents |
US5395754A (en) * | 1992-07-31 | 1995-03-07 | Hybritech Incorporated | Membrane-based immunoassay method |
CA2146964C (en) * | 1992-10-15 | 2005-11-29 | Olavi Siiman | Particles having gelatin-aminodextran coatings of and processes for making same |
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
CA2166705C (en) * | 1993-07-08 | 2004-11-09 | Mitsuo Isomura | Magnetic particles with gelatin and immunoassay using the same |
AU687033B2 (en) * | 1993-09-13 | 1998-02-19 | Ciba Corning Diagnostics Corp. | Undercoating of solid phase surfaces and direct coating method |
CA2184282A1 (en) * | 1994-03-07 | 1995-09-14 | Olavi Siiman | Covalent immobilized antibodies on polymeric beads |
US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
BE1008221A3 (fr) * | 1994-03-28 | 1996-02-20 | Anda Biolog Sa | Support solide fixant au moins un composant a activite biologique comprenant un site reactionnel, stabilise et procede pour son obtention. |
ZA962939B (en) * | 1995-04-12 | 1997-10-13 | Quest Int | Oral care compositions. |
US5660990A (en) * | 1995-08-18 | 1997-08-26 | Immunivest Corporation | Surface immobilization of magnetically collected materials |
IN182876B (de) * | 1995-11-22 | 1999-07-31 | Abion Ohg | |
PT876165E (pt) * | 1995-12-18 | 2006-10-31 | Angiotech Biomaterials Corp | Composicoes de polimeros reticulados e processos para a sua utilizacao |
US6833408B2 (en) | 1995-12-18 | 2004-12-21 | Cohesion Technologies, Inc. | Methods for tissue repair using adhesive materials |
US6458889B1 (en) | 1995-12-18 | 2002-10-01 | Cohesion Technologies, Inc. | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
US7883693B2 (en) | 1995-12-18 | 2011-02-08 | Angiodevice International Gmbh | Compositions and systems for forming crosslinked biomaterials and methods of preparation of use |
US5834121A (en) * | 1996-01-16 | 1998-11-10 | Solid Phase Sciences Corp. | Composite magnetic beads |
US5814468A (en) * | 1996-03-27 | 1998-09-29 | Coulter International Corp. | Methods of enumerating receptor molecules for specific binding partners on formed bodies and in solution |
JP3160230B2 (ja) * | 1996-09-25 | 2001-04-25 | 三洋化成工業株式会社 | 熱溶融性改良剤および熱溶融性樹脂組成物 |
FR2758884B1 (fr) | 1997-01-30 | 1999-04-02 | Bio Merieux | Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu |
US7229841B2 (en) | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
US6407218B1 (en) * | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
US6231982B1 (en) | 1997-12-10 | 2001-05-15 | Dade Behring Inc. | Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group |
EP1264181B1 (de) * | 2000-03-06 | 2007-06-06 | Dade Behring Marburg GmbH | Mit polysacchariden beschichtete träger, deren herstellung und verwendung |
ATE349011T1 (de) | 2000-10-03 | 2007-01-15 | Minerva Biotechnologies Corp | Magnetisches in situ dilutionsverfahren |
US7041787B2 (en) * | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Design and use of advanced zinc chelating peptides to regulate matrix metalloproteinases |
US6600057B2 (en) | 2000-12-29 | 2003-07-29 | Kimberly-Clark Worldwide, Inc. | Matrix metalloproteinase inhibitors |
JP3728411B2 (ja) * | 2001-09-18 | 2005-12-21 | ソニー株式会社 | 磁性粒子の作製方法、磁性粒子および磁性材料 |
US20030119073A1 (en) * | 2001-12-21 | 2003-06-26 | Stephen Quirk | Sensors and methods of detection for proteinase enzymes |
US6884829B2 (en) * | 2002-10-18 | 2005-04-26 | Robert L. Albright | Hemocompatible coated polymer and related one-step methods |
US7112620B2 (en) | 2002-10-18 | 2006-09-26 | Albright Robert L | Hemocompatible polymer systems & related methods |
US7629049B2 (en) * | 2002-10-18 | 2009-12-08 | Medasorb, Inc. | Hemocompatible polymer systems and related devices |
ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
FR2855613B1 (fr) * | 2003-05-26 | 2005-08-19 | Biocytex | Procede de detection et de quantification multiplex d'analytes dans un echantillon a l'aide de microspheres |
US20050208095A1 (en) * | 2003-11-20 | 2005-09-22 | Angiotech International Ag | Polymer compositions and methods for their use |
EP1694301A4 (de) | 2003-12-02 | 2009-11-18 | Cytimmune Sciences Inc | Verfahren und zusammensetzungen zur herstellung von monoklonalen antikörpern |
US20050175584A1 (en) * | 2004-01-28 | 2005-08-11 | Paciotti Giulio F. | Functionalized colloidal metal compositions and methods |
NZ550964A (en) | 2004-04-28 | 2011-05-27 | Angiodevice Internat Gmbh | Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use |
JP4581571B2 (ja) * | 2004-09-06 | 2010-11-17 | 富士ゼロックス株式会社 | 粒子のマレイミジル基量を測定する定量方法 |
WO2006034128A2 (en) | 2004-09-17 | 2006-03-30 | Angiotech Biomaterials Corporation | Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use |
US9604196B2 (en) | 2006-11-20 | 2017-03-28 | Cytosorbent, Inc. | Size-selective hemocompatible polymer system |
CN100532436C (zh) * | 2007-08-03 | 2009-08-26 | 中国科学院广州化学研究所 | 一种水分散磁性高分子微球及其制备方法和应用 |
WO2009062151A1 (en) * | 2007-11-08 | 2009-05-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
US9211519B2 (en) | 2009-10-08 | 2015-12-15 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Methods to prepare patchy microparticles |
JP5865252B2 (ja) | 2009-11-02 | 2016-02-17 | パルス セラピューティクス インコーポレイテッド | 起磁性ステーターシステム及び磁性ローターの無線制御方法 |
US8911780B2 (en) | 2011-02-11 | 2014-12-16 | Zx Pharma, Llc | Multiparticulate L-menthol formulations and related methods |
WO2013002309A1 (ja) * | 2011-06-29 | 2013-01-03 | 三菱化学メディエンス株式会社 | 非特異反応抑制剤、非特異反応抑制方法及びキット |
EP2849657B1 (de) * | 2012-05-15 | 2018-08-29 | Pulse Therapeutics, Inc. | Magnetbasierte systeme zur manipulation magnetischer teilchen |
CN105263480B (zh) * | 2013-04-23 | 2018-08-28 | Zx制药有限责任公司 | 肠溶包衣的多微粒控释薄荷油组合物和相关方法 |
EP2955521A1 (de) * | 2014-06-11 | 2015-12-16 | Centre Hospitalier Universitaire Vaudois (CHUV) | Verfahren zur Trennung von Zellen |
CA2984506A1 (en) | 2015-05-01 | 2016-11-10 | BioLegend, Inc. | Stable nanomagnetic particle dispersions |
US20180164299A1 (en) * | 2015-06-26 | 2018-06-14 | Maggenome Tech Pvt Ltd | Entrapment of magnetic nanoparticles in a cross-linked protein matrix without affecting the functional properties of the protein |
EP4134427A1 (de) | 2016-04-30 | 2023-02-15 | Biolegend, Inc. | Zusammensetzungen und verfahren zur durchführung von magnetisboyanttrennungen |
WO2018106938A1 (en) * | 2016-12-07 | 2018-06-14 | Pendant Biosciences, Inc. | Crosslinked coatings |
AU2017393322B2 (en) | 2017-01-10 | 2020-07-09 | Unilever Global Ip Limited | Biofilm targeting microcapsule carrying a non-volatile functional material |
CN107376008B (zh) * | 2017-07-21 | 2019-10-22 | 深圳华诺生物科技有限公司 | 一种无机纳米颗粒-明胶核壳结构复合材料颗粒的制备方法 |
US11918315B2 (en) | 2018-05-03 | 2024-03-05 | Pulse Therapeutics, Inc. | Determination of structure and traversal of occlusions using magnetic particles |
CN109569457B (zh) * | 2018-10-19 | 2022-03-22 | 北京纳诺金生物科技有限公司 | 亚微米级功能球及其制备方法和应用 |
CN113896785B (zh) * | 2021-09-14 | 2023-09-08 | 罗赛洛(温州)明胶有限公司 | 一种抗交联明胶的制备方法 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5814253B2 (ja) * | 1974-04-10 | 1983-03-18 | カンザキセイシ カブシキガイシヤ | ビシヨウカプセルノ セイゾウホウホウ |
US3970518A (en) * | 1975-07-01 | 1976-07-20 | General Electric Company | Magnetic separation of biological particles |
US4210418A (en) * | 1976-08-30 | 1980-07-01 | Mallinckrodt, Inc. | Container for immunochemical and enzymatical determinations or procedures |
GB2013688B (en) * | 1978-01-26 | 1982-06-30 | Technicon Instr | Insolubilised proteins and immunoassays utilising them |
US4267234A (en) * | 1978-03-17 | 1981-05-12 | California Institute Of Technology | Polyglutaraldehyde synthesis and protein bonding substrates |
FR2480764B1 (fr) * | 1980-04-18 | 1985-10-04 | Rhone Poulenc Spec Chim | Latex de polymeres magnetiques et procede de preparation |
US4438239A (en) * | 1981-03-30 | 1984-03-20 | California Institute Of Technology | Microsphere coated substrate containing reactive aldehyde groups |
IL63220A (en) * | 1981-07-01 | 1985-09-29 | Yeda Res & Dev | Process for production of polyacrolein microspheres |
US4478946A (en) * | 1981-07-02 | 1984-10-23 | South African Inventions Development Corporation | Carrier bound immunosorbent |
US4454234A (en) * | 1981-12-30 | 1984-06-12 | Czerlinski George H | Coated magnetizable microparticles, reversible suspensions thereof, and processes relating thereto |
US4452773A (en) * | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
NO155316C (no) * | 1982-04-23 | 1987-03-11 | Sintef | Fremgangsmaate for fremstilling av magnetiske polymerpartikler. |
US4554088A (en) * | 1983-05-12 | 1985-11-19 | Advanced Magnetics Inc. | Magnetic particles for use in separations |
US4920061A (en) * | 1984-03-02 | 1990-04-24 | The University Of Texas System | Biological magnetic colloids |
US4582622A (en) * | 1984-10-12 | 1986-04-15 | Fujirebio Kabushiki Kaisha | Magnetic particulate for immobilization of biological protein and process of producing the same |
US4795698A (en) * | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
US4814098A (en) * | 1986-09-06 | 1989-03-21 | Bellex Corporation | Magnetic material-physiologically active substance conjugate |
DE3807904A1 (de) * | 1988-03-10 | 1989-09-21 | Behringwerke Ag | Magnetische protein-konjugate, verfahren zu ihrer herstellung und ihre verwendung |
US4965007A (en) * | 1988-05-10 | 1990-10-23 | Eastman Kodak Company | Encapsulated superparamagnetic particles |
US5093475A (en) * | 1988-12-22 | 1992-03-03 | Xoma Corporation | Hindered linking agents derived from 2-iminothiolanes and methods |
US5062991A (en) * | 1990-06-04 | 1991-11-05 | Coulter Corporation | In situ use of gelatin in the preparation of uniform ferrite particles |
-
1990
- 1990-10-31 US US07/607,253 patent/US5169754A/en not_active Expired - Lifetime
-
1991
- 1991-10-25 JP JP50515992A patent/JP3297046B2/ja not_active Expired - Fee Related
- 1991-10-25 EP EP92904811A patent/EP0556346B1/de not_active Expired - Lifetime
- 1991-10-25 AU AU12543/92A patent/AU665730B2/en not_active Ceased
- 1991-10-25 DE DE69132657T patent/DE69132657T2/de not_active Expired - Fee Related
- 1991-10-25 CA CA002095148A patent/CA2095148A1/en not_active Abandoned
- 1991-10-25 WO PCT/US1991/007911 patent/WO1992008134A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
AU1254392A (en) | 1992-05-26 |
JP3297046B2 (ja) | 2002-07-02 |
EP0556346B1 (de) | 2001-07-11 |
JPH07500278A (ja) | 1995-01-12 |
WO1992008134A1 (en) | 1992-05-14 |
EP0556346A1 (de) | 1993-08-25 |
DE69132657T2 (de) | 2002-06-20 |
AU665730B2 (en) | 1996-01-11 |
CA2095148A1 (en) | 1992-05-01 |
US5169754A (en) | 1992-12-08 |
EP0556346A4 (en) | 1994-05-25 |
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