DE69133149T2 - Benzimidazolderivate, ihre Herstellung und Verwendung als Angiotensin II-Antagonisten - Google Patents

Benzimidazolderivate, ihre Herstellung und Verwendung als Angiotensin II-Antagonisten

Info

Publication number
DE69133149T2
DE69133149T2 DE69133149T DE69133149T DE69133149T2 DE 69133149 T2 DE69133149 T2 DE 69133149T2 DE 69133149 T DE69133149 T DE 69133149T DE 69133149 T DE69133149 T DE 69133149T DE 69133149 T2 DE69133149 T2 DE 69133149T2
Authority
DE
Germany
Prior art keywords
anion
benzimidazole
substd
opt
angiotensin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133149T
Other languages
English (en)
Other versions
DE69133149D1 (de
Inventor
Takehiko Naka
Kohei Nishikawa
Takeshi Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27526589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69133149(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69133149D1 publication Critical patent/DE69133149D1/de
Application granted granted Critical
Publication of DE69133149T2 publication Critical patent/DE69133149T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
DE69133149T 1990-04-27 1991-04-19 Benzimidazolderivate, ihre Herstellung und Verwendung als Angiotensin II-Antagonisten Expired - Lifetime DE69133149T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP11314890 1990-04-27
JP14194290 1990-05-30
JP20866290 1990-08-06
JP26457990 1990-10-01
JP41367990 1990-12-24

Publications (2)

Publication Number Publication Date
DE69133149D1 DE69133149D1 (de) 2002-12-19
DE69133149T2 true DE69133149T2 (de) 2003-03-13

Family

ID=27526589

Family Applications (3)

Application Number Title Priority Date Filing Date
DE1998175004 Active DE19875004I2 (de) 1990-04-27 1991-04-19 Benzimidazolderivate Verfahren zu deren Herstellung und Anwendung
DE69133149T Expired - Lifetime DE69133149T2 (de) 1990-04-27 1991-04-19 Benzimidazolderivate, ihre Herstellung und Verwendung als Angiotensin II-Antagonisten
DE69123784T Expired - Lifetime DE69123784T2 (de) 1990-04-27 1991-04-19 Benzimidazolderivate, Verfahren zu deren Herstellung und Anwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE1998175004 Active DE19875004I2 (de) 1990-04-27 1991-04-19 Benzimidazolderivate Verfahren zu deren Herstellung und Anwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69123784T Expired - Lifetime DE69123784T2 (de) 1990-04-27 1991-04-19 Benzimidazolderivate, Verfahren zu deren Herstellung und Anwendung

Country Status (22)

Country Link
US (4) US5196444A (de)
EP (2) EP0459136B1 (de)
JP (2) JP2514282B2 (de)
KR (1) KR100200541B1 (de)
CN (2) CN1048486C (de)
AT (2) ATE146779T1 (de)
CA (2) CA2204290C (de)
CY (1) CY2150B1 (de)
DE (3) DE19875004I2 (de)
DK (2) DK0720982T3 (de)
ES (2) ES2181742T3 (de)
FI (2) FI108434B (de)
GR (1) GR3022172T3 (de)
HK (1) HK1000803A1 (de)
HU (2) HU213266B (de)
IE (1) IE911317A1 (de)
LU (1) LU90224I2 (de)
LV (1) LV10258B (de)
NL (1) NL970044I2 (de)
NO (3) NO300923B1 (de)
NZ (1) NZ237949A (de)
PT (1) PT97451B (de)

Families Citing this family (226)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332744A (en) * 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
US5223499A (en) * 1989-05-30 1993-06-29 Merck & Co., Inc. 6-amino substituted imidazo[4,5-bipyridines as angiotensin II antagonists
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
DE4036706A1 (de) * 1990-11-17 1992-05-21 Hoechst Ag Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie
GB9027198D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
GB9027208D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
FR2673427B1 (fr) * 1991-03-01 1993-06-18 Sanofi Elf Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
TW274551B (de) * 1991-04-16 1996-04-21 Takeda Pharm Industry Co Ltd
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
US5354759A (en) * 1991-09-12 1994-10-11 Fujisawa Pharmaceutical Co., Ltd. Angiotenin II antagonizing heterocyclic compounds
GB9201789D0 (en) * 1992-01-28 1992-03-11 Fujisawa Pharmaceutical Co Heterocyclic derivatives
JP2682353B2 (ja) * 1991-11-20 1997-11-26 武田薬品工業株式会社 経口用医薬組成物およびその製造法
TW284688B (de) * 1991-11-20 1996-09-01 Takeda Pharm Industry Co Ltd
DE4203872A1 (de) * 1992-02-11 1993-08-12 Thomae Gmbh Dr K Imidazo(1,2-a)pyridine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPH07507271A (ja) * 1992-03-03 1995-08-10 藤沢薬品工業株式会社 アンジオテンシン１１拮抗剤としてのベンズイミダゾール誘導体
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
US5266583A (en) * 1992-09-01 1993-11-30 Merck & Co., Inc. Angitotensin II antagonist
DK154092D0 (da) * 1992-12-23 1992-12-23 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
US5605919A (en) * 1993-02-26 1997-02-25 Takeda Chemical Industries, Ltd. Treatment for viral diseases
CA2115985A1 (en) * 1993-02-25 1994-08-26 Kohei Nishikawa Vascular hypertrophy suppressor
JP3810020B2 (ja) * 1993-04-22 2006-08-16 武田薬品工業株式会社 腎疾患の予防または治療剤
JP2003306432A (ja) * 1993-04-22 2003-10-28 Takeda Chem Ind Ltd 腎疾患の予防または治療剤
JP3057471B2 (ja) * 1993-06-07 2000-06-26 武田薬品工業株式会社 アンジオテンシンｉｉ介在性諸疾患の予防または治療剤
US5721263A (en) * 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
CA2125251C (en) * 1993-06-07 2005-04-26 Yoshiyuki Inada A pharmaceutical composition for angiotensin ii-mediated diseases
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
US5391566A (en) * 1993-07-20 1995-02-21 Merck & Co., Inc. Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives
ZA945190B (en) * 1993-07-30 1995-02-24 Kotobuki Seiyaku Co Ltd Carboxymethylidenecycloheptimidazole derivatives method or manufacturing the same and therapeutic agents containing these compounds
US5824696A (en) * 1993-09-01 1998-10-20 Smithkline Beecham Corporation Medicaments
US6676967B1 (en) * 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
DK0668272T3 (da) * 1994-01-28 2000-09-18 Takeda Chemical Industries Ltd Fremgangsmåde til fremstilling af tetrazolylforbindelser
DE4408497A1 (de) * 1994-03-14 1995-09-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
MX9604109A (es) * 1994-03-16 1997-09-30 Sankyo Co Agente para disminuir la tension ocular.
AU677702B2 (en) * 1994-10-13 1997-05-01 Takeda Pharmaceutical Company Limited A prophylactic or therapeutic drug for renal diseases
SE9501881D0 (sv) * 1995-05-19 1995-05-19 Astra Ab New pharmacological use of AII-receptor antagonists
SE9502219D0 (sv) * 1995-06-19 1995-06-19 Astra Ab Novel medical use
PT853477E (pt) * 1995-10-06 2003-01-31 Novartis Ag Antagonistas de receptores at1 para prevencao e tratamento de insuficiencia renal pos-isquemica e para proteccao de rim isquemico
WO1997024334A1 (fr) 1995-12-28 1997-07-10 Fujisawa Pharmaceutical Co., Ltd. Derives du benzimidazole
DK0883401T3 (da) 1996-02-29 2003-05-05 Novartis Ag AT1-receptorantagonist til stimulering af apoptose
CN1215338A (zh) * 1996-04-05 1999-04-28 武田药品工业株式会社 包含具有血管紧张素ⅱ拮抗活性的化合物的药物组合物
US5771604A (en) * 1997-04-07 1998-06-30 Maytag Corporation Clothes dryer air inlet arrangement
US6177587B1 (en) * 1997-05-26 2001-01-23 Takeda Chemical Industries, Ltd. Production method of aminobenzene compound
TW453999B (en) 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
CA2306216C (en) 1997-10-17 2011-06-07 Eurogene Limited The use of inhibitors of the renin-angiotensin system for the treatment of cachexia and wasting
EP1069113A1 (de) * 1998-02-23 2001-01-17 Kureha Chemical Industry Co., Ltd. Benzimidazolderivate
DE19820151A1 (de) * 1998-05-06 1999-11-11 Hexal Ag Transdermales therapeutisches System zur Anwendung von Candesartan
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
JP3923255B2 (ja) 1998-07-15 2007-05-30 帝人株式会社 チオベンズイミダゾール誘導体
US6465502B1 (en) 1998-12-23 2002-10-15 Novartis Ag Additional therapeutic use
SI1588706T1 (sl) 1998-12-23 2012-01-31 Novartis Ag Tableta valsartana
CN101011390A (zh) 1999-01-26 2007-08-08 诺瓦提斯公司 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用
GB0001662D0 (en) * 1999-02-06 2000-03-15 Zeneca Ltd Pharmaceutical compositions
US7378108B1 (en) 1999-02-19 2008-05-27 Takeda Pharmaceutical Company Limited Percutaneous absorption preparation of compound having angiotensin II antagonistic activity
US6211217B1 (en) 1999-03-16 2001-04-03 Novartis Ag Method for reducing pericardial fibrosis and adhesion formation
US6972287B1 (en) 1999-06-10 2005-12-06 Pfizer Inc. Method of inhibiting amyloid protein aggregation and imaging amyloid deposits
SK17632001A3 (sk) * 1999-06-10 2003-03-04 Warner-Lambert Company Liečivo na liečbu Alzheimerovej choroby, inhibíciu agregácie amyloidového proteínu a spôsob na zobrazenie depozít amyloidu
WO2001005428A1 (fr) * 1999-07-21 2001-01-25 Takeda Chemical Industries, Ltd. Methodes preventives contre la recurrence d'une insuffisance cerebrovasculaire, et agents destines a ameliorer des troubles causes par une insuffisance cerebrovasculaire et a inhiber leur evolution
SE9903028D0 (sv) 1999-08-27 1999-08-27 Astra Ab New use
PL353199A1 (en) * 1999-08-30 2003-11-03 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
WO2001060362A1 (en) * 2000-02-18 2001-08-23 Takeda Chemical Industries, Ltd. TNF-α INHIBITORS
SE0002353D0 (sv) * 2000-06-22 2000-06-22 Astrazeneca Ab New use
ES2299501T3 (es) * 2000-08-11 2008-06-01 Boehringer Ingelheim Pharmaceuticals Inc. Compuestos heterociclicos utiles como inhibidores de tirosina-quinasas.
PE20020617A1 (es) 2000-08-22 2002-08-05 Novartis Ag Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
EP1314425A4 (de) * 2000-08-30 2004-06-02 Sankyo Co Medizinische zusammenstellung zur prophylaxe und behandlung von herzversagen
EP1329218A4 (de) * 2000-10-25 2007-04-04 Takeda Pharmaceutical Wirkstoffe zur vorbeugung und behandlung portaler hypertonie
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
EP1346722B1 (de) 2000-12-01 2008-12-10 Takeda Pharmaceutical Company Limited Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz
US7067546B2 (en) * 2001-08-03 2006-06-27 Takeda Pharmaceutical Company Crystal and process for producing the same
PL368843A1 (en) * 2001-08-28 2005-04-04 Sankyo Company, Limited Medicinal compositions containing angiotensin ii receptor antagonist
US7107198B2 (en) * 2001-11-02 2006-09-12 Sun Microsystems, Inc. Automatic generation of reduced-size circuit models including inductive interaction
WO2003041739A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticaner agents
DE10205335A1 (de) * 2002-02-07 2003-08-21 Bdd Group Holding Ag Zug Deuterierte biphenylsubstituierte Benzimidazole sowie diese Verbindungen enthaltende Arzneimittel
WO2003074008A2 (en) * 2002-03-01 2003-09-12 Merck & Co., Inc. Aminoalkylphosphonates and related compounds as edg receptor agonists
US7232828B2 (en) * 2002-08-10 2007-06-19 Bethesda Pharmaceuticals, Inc. PPAR Ligands that do not cause fluid retention, edema or congestive heart failure
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
DE10335027A1 (de) 2003-07-31 2005-02-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von Angiotensin II Rezeptor Antagonisten
CA2519490A1 (en) * 2003-03-17 2004-09-30 Teva Pharmaceutical Industries Ltd Polymorphis of valsartan
WO2004085426A1 (en) * 2003-03-27 2004-10-07 Hetero Drugs Limited Novel crystalline forms of candesartan cilexetil
SE0300988D0 (sv) * 2003-04-03 2003-04-03 Astrazeneca Ab New use
EP1556363A2 (de) * 2003-04-21 2005-07-27 Teva Pharmaceutical Industries Limited Verfahren zur herstellung von valsartan und zwischenprodukte davon
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0316546D0 (en) 2003-07-15 2003-08-20 Novartis Ag Process for the manufacture of organic compounds
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
SK50142006A3 (sk) * 2003-08-27 2006-05-04 Zentiva, A. S. Spôsob odstraňovania trifenylmetánovej ochrannej skupiny
WO2005030202A1 (en) * 2003-09-26 2005-04-07 Novartis Ag Use of angiotensin ii receptor antagonists for treating cerebrovascular disorders
GB0322552D0 (en) * 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
DE602004005488T2 (de) * 2003-10-16 2007-11-29 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von candesartan cilexetil
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
EP2428516A1 (de) 2003-11-19 2012-03-14 Metabasis Therapeutics, Inc. Neue Phosphor enthaltende Thyromimetika
WO2005051928A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Process for production of tetrazolyl compounds
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
JP2005206603A (ja) * 2004-01-21 2005-08-04 Teva Pharmaceutical Industries Ltd カンデサルタンシレキセチルの調製
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
CA2555294A1 (en) * 2004-02-11 2005-08-25 Marina Yu Etinger Candesartan cilexetil polymorphs
US7157584B2 (en) 2004-02-25 2007-01-02 Takeda Pharmaceutical Company Limited Benzimidazole derivative and use thereof
NZ586285A (en) 2004-03-17 2011-12-22 Novartis Ag Use of aliskiren in monotherapy for treating diabetes and metabolic disorder (syndrome X)
WO2005117870A2 (en) * 2004-04-16 2005-12-15 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
CN1953973A (zh) * 2004-05-05 2007-04-25 特瓦制药工业有限公司 高纯度坎地沙坦酯的制备
JP2005330277A (ja) * 2004-05-19 2005-12-02 Teva Pharmaceutical Industries Ltd カンデサルタンシレキセチル多形体
JP2009185060A (ja) * 2004-05-19 2009-08-20 Teva Pharmaceutical Industries Ltd カンデサルタンシレキセチル多形体
US7588779B2 (en) * 2004-05-28 2009-09-15 Andrx Labs, Llc Pharmaceutical formulation containing a biguanide and an angiotensin antagonist
WO2005123720A1 (en) * 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof
US7754747B2 (en) 2004-08-23 2010-07-13 Wyeth Llc Oxazolo-naphthyl acids
US7605172B2 (en) 2004-08-23 2009-10-20 Wyeth Thiazolo-naphthyl acids
WO2006023864A1 (en) 2004-08-23 2006-03-02 Wyeth Pyrrolo-naphthyl acids as pai-1 inhibitors
EP2248520A3 (de) 2004-10-08 2010-11-17 Novartis AG Verwendung von Reninhemmern zur Prävention oder Behandlung von diastolischer Dysfunktion oder diastolischer Herzinsuffizienz
EP1806332A4 (de) 2004-10-27 2010-03-31 Daiichi Sankyo Co Ltd Benzolverbindung mit zwei oder mehrsubstituenten
US8022086B2 (en) * 2004-10-29 2011-09-20 Kowa Co., Ltd. Therapeutic agent for glomerular disease
EP1655298A1 (de) * 2004-11-03 2006-05-10 LEK Pharmaceuticals d.d. Krystalline Polymorpheme Formen von Candesartan Cilexetil
EP1812423A1 (de) * 2004-11-11 2007-08-01 LEK Pharmaceuticals D.D. Verfahren zur synthese von tetrazolen
ES2328384T3 (es) * 2004-11-23 2009-11-12 Warner-Lambert Company Llc Derivados del acido 7-(2h-pirazol-3-il)-3,5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de la lipidemia.
DE102004060699A1 (de) * 2004-12-16 2006-06-22 Ratiopharm Gmbh Verfahren zur Herstellung von Candesartan
EP1833801B9 (de) * 2004-12-22 2009-02-25 Algry Quimica, S.L Zwischenprodukte für die herstellung von antagonisten des angiotensin-ii-rezeptors
CA2594332A1 (en) * 2005-01-06 2006-07-13 Elan Pharma International Ltd. Nanoparticulate candesartan formulations
CN101103021A (zh) * 2005-01-14 2008-01-09 特瓦制药工业有限公司 粗坎地沙坦西酯的制备
WO2006079496A1 (en) * 2005-01-26 2006-08-03 Lek Pharmaceuticals D.D. New pharmaceutical composition containing candesartan cilexetil as lipophilic crystalline substance
GEP20115138B (en) * 2005-03-30 2011-01-10 Takeda Pharmaceuticals Co Benzimidazole derivative and use as angiotensin ii antagonist
TW200719896A (en) * 2005-04-18 2007-06-01 Astrazeneca Ab Combination product
CN100400536C (zh) * 2005-04-30 2008-07-09 重庆圣华曦药业有限公司 坎地沙坦酯c-型晶体的制备方法
EP2210888B1 (de) 2005-05-10 2013-04-24 Teva Pharmaceutical Industries, Ltd. Stabiles mikronisiertes Candesartan-Cilexetil und Herstellungsverfahren
EP1896455A2 (de) 2005-06-06 2008-03-12 Medichem, S.A. Verfahren zur herstellung von tetrazolylverbindungen
ES2264641B1 (es) * 2005-06-17 2008-03-01 Quimica Sintetica, S.A. Procedimiento para la obtencion de derivados de bencimidazol y sus intermedios.
BRPI0613430A2 (pt) 2005-07-13 2011-01-11 Hoffmann La Roche compostos derivados de benzimidazol, uso dos mesmos, método para a preparação destes e composição farmacêutica
SI22127A (sl) 2005-10-07 2007-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo kandesartan cileksetila
CZ299265B6 (cs) * 2005-10-20 2008-05-28 Zentiva, A. S. Zpusob výroby 1-(cyklohexyloxykarbonyloxy)ethyl-2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)bifenyl-4-yl]methyl]benzimidazol-7-karboxylátu (candesartan cilexetilu)
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
CN100344625C (zh) * 2005-12-22 2007-10-24 浙江天宇药业有限公司 一种制备坎地沙坦的方法
WO2007094015A1 (en) * 2006-02-15 2007-08-23 Matrix Laboratories Ltd An improved process for the preparation of candesartan cilexetil
CN101024643A (zh) 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
WO2008035360A2 (en) * 2006-06-13 2008-03-27 Alembic Limited Novel crystalline forms of candesartan cilexetil, candesartan, tritylated candesartan and tritylated candesartan cilexetil
WO2008012371A1 (en) * 2006-07-28 2008-01-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of amorphous and crystalline forms of candesartan cilexetil using column chromatography
MX2009001429A (es) 2006-08-10 2009-02-17 Takeda Pharmaceutical Composicion farmaceutica.
GB2444593B (en) 2006-10-05 2010-06-09 Santarus Inc Novel formulations for immediate release of proton pump inhibitors and methods of using these formulations
EP1908469A1 (de) 2006-10-06 2008-04-09 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II Rezeptor Antagonisten zur Behandlung von systemischen Krankheiten bei Katzen
WO2008044244A2 (en) * 2006-10-10 2008-04-17 Matrix Laboratories Ltd One pot process for the preparation of candesartan
MX2009004475A (es) 2006-10-27 2009-08-12 Univ Missouri Composiciones que comprenden agentes acido labiles que inhiben la bomba de protones, por lo menos otro agente farmaceuticamente activo y metodos de uso de las misma.
ES2315141B1 (es) * 2006-11-23 2009-12-22 Quimica Sintetica, S.A Procedimiento para la preparacion de cardesartan cilexetilo en forma cristalina.
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
JP5290190B2 (ja) * 2006-12-06 2013-09-18 サルブリス・アセット・マネイジメント・カンパニー・リミテッド イミダゾール−５−カルボン酸誘導体の塩、製造方法及びその医薬組成物
CN101214242A (zh) 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
EP1952806A1 (de) 2007-02-01 2008-08-06 Helm AG Herstellungsverfahren für Candesartan-Adsorbate
TW200838501A (en) 2007-02-02 2008-10-01 Theravance Inc Dual-acting antihypertensive agents
WO2008096829A1 (ja) 2007-02-07 2008-08-14 Kyowa Hakko Kirin Co., Ltd. ３環系化合物
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
ATE479427T1 (de) * 2007-03-08 2010-09-15 Teva Pharma Pharmazeutische zusammensetzung mit candesartan- cilexetil
WO2008123536A1 (en) * 2007-03-28 2008-10-16 Takeda Pharmaceutical Company Limited Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a ph control agent
DK2142514T3 (da) 2007-04-18 2015-03-23 Probiodrug Ag Thioureaderivater som glutaminylcyclase-inhibitorer
TWI448284B (zh) 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
SI22488A (sl) * 2007-04-24 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalni 1-(cikloheksiloksikarboniloksi)etil 1-((2'-cianobifenil-4-il)metil) - 2-etoksi-1h-benz(d)imidazol -7-karboksilat in proces za njegovo pripravo
JP5139515B2 (ja) 2007-04-25 2013-02-06 テバ ファーマシューティカル インダストリーズ リミティド 医薬賦形剤複合体
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2998314B1 (de) 2007-06-04 2020-01-22 Bausch Health Ireland Limited Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
TWI406850B (zh) * 2007-06-05 2013-09-01 Theravance Inc 雙效苯并咪唑抗高血壓劑
EP2170868A1 (de) * 2007-07-11 2010-04-07 Alembic Limited Verbessertes verfahren zur herstellung von candesartancilexetil
WO2009035543A1 (en) 2007-09-07 2009-03-19 Theravance, Inc. Dual-acting antihypertensive agents
US8212052B2 (en) 2007-12-11 2012-07-03 Theravance, Inc. Dual-acting benzoimidazole antihypertensive agents
CA2716367C (en) 2008-02-20 2015-05-26 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
JP2011518884A (ja) 2008-04-29 2011-06-30 セラヴァンス， インコーポレーテッド 二重活性抗高血圧剤
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US20100210853A1 (en) * 2008-06-24 2010-08-19 Hetero Research Foundation Process for preparation of candesartan cilexetil
WO2010009319A2 (en) 2008-07-16 2010-01-21 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JP2011529072A (ja) * 2008-07-24 2011-12-01 セラヴァンス， インコーポレーテッド 二重作用血圧降下薬
CN101648918B (zh) * 2008-08-15 2013-01-09 联化科技股份有限公司 坎地沙坦酯的中间体化合物及其合成方法
SI2165702T1 (sl) 2008-09-17 2012-05-31 Helm Ag Stabilni in z lahkoto raztopljeni sestavki kandesartan cileksetila pripravljeni z vlažno granulacijo
AU2009302285A1 (en) * 2008-10-10 2010-04-15 Janssen Pharmaceutica Nv Combination therapy comprising angiotensin receptor blockers and vasopressin receptor antagonists
KR100995755B1 (ko) 2008-10-31 2010-11-19 일동제약주식회사 트리틸 칸데사르탄 실렉세틸의 개선된 제조방법
DE102008059206A1 (de) 2008-11-27 2010-06-10 Bayer Schering Pharma Aktiengesellschaft Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
US9387249B2 (en) 2008-12-23 2016-07-12 Takeda Pharmaceutical Company Limited Methods of treating hypertension with at least one angiotensin II receptor blocker and chlorthalidone
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
ES2611107T3 (es) 2009-07-07 2017-05-04 Theravance Biopharma R&D Ip, Llc Agentes antihipertensivos de pirazol, de doble acción
JP2012533626A (ja) 2009-07-22 2012-12-27 セラヴァンス， インコーポレーテッド 二重作用オキサゾール降圧剤
CA2772488C (en) 2009-09-11 2018-04-17 Probiodrug Ag Heterocyclic derivatives as inhibitors of glutaminyl cyclase
WO2011080684A1 (en) 2009-12-31 2011-07-07 Ranbaxy Laboratories Limited Process for the preparation of candesartan cilexetil
WO2011090929A1 (en) 2010-01-19 2011-07-28 Theravance, Inc. Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
WO2011092666A1 (en) 2010-01-29 2011-08-04 Ranbaxy Laboratories Limited An improved process for the preparation of candesartan cilexetil, polymorphic forms of n-trityl candesartan and their uses thereof
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
EP2560953B1 (de) 2010-04-21 2016-01-06 Probiodrug AG Hemmer der glutaminylzyklase
CN101880241B (zh) * 2010-07-14 2013-04-17 浙江美诺华药物化学有限公司 一锅法制备2-(取代苯基)甲氨基-3-硝基苯甲酸甲酯的方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
KR101251741B1 (ko) * 2010-12-16 2013-04-05 동화약품주식회사 칸데사르탄실렉세틸의 개선된 제조방법
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
CN102198129B (zh) * 2011-03-22 2016-03-30 浙江华海药业股份有限公司 含有坎地沙坦酯和氢氯噻嗪的口服片剂
CN102206186A (zh) * 2011-04-18 2011-10-05 张家港市信谊化工有限公司 坎地沙坦环合物的制备方法
BR112014004370A2 (pt) 2011-08-26 2017-03-21 Wockhardt Ltd métodos para tratar distúrbios cardiovasculares
WO2013041944A1 (en) 2011-09-19 2013-03-28 Ranbaxy Laboratories Limited Process for the preparation of micronized candesartan cilexetil
JP5850697B2 (ja) * 2011-10-18 2016-02-03 株式会社トクヤマ カンデサルタンシレキセチルの製造方法
US20130158080A1 (en) 2011-12-15 2013-06-20 Takeda Pharmaceuticals U.S.A., Inc. Methods for treating hypertension in black patients
CN102391254B (zh) * 2011-12-16 2013-03-13 珠海润都制药股份有限公司 一种坎地沙坦的制备方法
CN103304543A (zh) * 2012-03-12 2013-09-18 邓俐丽 一种坎地沙坦酯的制备方法
CN102633816A (zh) * 2012-03-30 2012-08-15 李莎 头孢西丁酯化前体药物化合物及口服制剂
CN104334173B (zh) 2012-05-01 2017-05-03 特兰斯拉图姆医学公司 用于治疗和诊断致盲性眼病的方法
SG11201406363VA (en) 2012-05-07 2014-11-27 Bayer Pharma AG Process for manufacturing a pharmaceutical dosage form comprising nifedipine and candesartan cilexetil
US20140134187A1 (en) 2012-06-25 2014-05-15 The Johns Hopkins University Therapeutic and diagnostic methods for autism spectrum disorders and other conditions
US9486503B2 (en) 2012-10-04 2016-11-08 Shionogi & Co., Ltd. Medicinal agent for suppressing malignant tumor metastasis
CN102952040A (zh) * 2012-11-20 2013-03-06 峨眉山天梁星制药有限公司 一种坎地沙坦酯中间体的硝基还原为氨基的方法
PL236001B1 (pl) 2012-12-21 2020-11-30 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Złożona kompozycja farmaceutyczna zawierająca kandesartan cyleksetylu oraz amlodypinę, sposób jej wytwarzania oraz jednostkowa postać dawkowania zawierająca tę kompozycję
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9339542B2 (en) * 2013-04-16 2016-05-17 John L Couvaras Hypertension reducing composition
SG11201507496UA (en) 2013-04-17 2015-11-27 Pfizer N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
JP6422868B2 (ja) 2013-07-23 2018-11-14 第一三共株式会社 高血圧症の予防又は治療のための医薬
CN104098550A (zh) * 2014-07-17 2014-10-15 浙江华海药业股份有限公司 一种精制三苯甲基坎地沙坦的方法
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
EP3312174B1 (de) * 2015-06-05 2019-12-18 Zhejiang Huahai Pharmaceutical Co., Ltd Verfahren zur herstellung von tritylcandesartan
CZ2015687A3 (cs) 2015-10-02 2017-04-12 Zentiva, K.S. Farmaceutická kompozice obsahující kombinaci kandesartanu, amlodipinu a hydrochlorthiazidu
EP3219309A1 (de) 2016-03-17 2017-09-20 K.H.S. Pharma Holding GmbH Pharmazeutische zusammensetzung mit fixdosierungskombination von amlodipin, candesartan cilexetil und hydrochlorothiazid zur behandlung von bluthochdruck
CA3015964C (en) 2016-03-24 2021-08-03 Daiichi Sankyo Company, Limited Medicine for treating renal disease
CN106432201B (zh) * 2016-09-14 2019-04-23 威海迪素制药有限公司 一种坎地沙坦酯结晶的制备方法
US10905676B2 (en) 2017-07-07 2021-02-02 Boehringer Ingelheim Vetmedica Gmbh Angiotensin II receptor antagonist for the prevention or treatment of systemic diseases in cats
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
WO2019200181A1 (en) 2018-04-11 2019-10-17 Ohio State Innovation Foundation Methods and compositions for sustained release microparticles for ocular drug delivery
EP3907215A4 (de) 2019-01-02 2022-03-16 Linhai Huanan Chemical Co., Ltd. Syntheseverfahren für candesartan-cilexetil-zwischenprodukt
AU2020209215B2 (en) 2019-01-18 2023-02-02 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof
CN110514758A (zh) * 2019-08-21 2019-11-29 天地恒一制药股份有限公司 一种坎地沙坦酯有关物质的检测方法
JP7440939B2 (ja) * 2020-08-13 2024-02-29 南京海融医薬科技股▲フン▼有限公司 イブプロフェンエステル系プロドラッグ、医薬組成物、調製方法および使用
US11655220B2 (en) 2020-10-22 2023-05-23 Hetero Labs Limited Process for the preparation of angiotensin II receptor blockers
EP4052695A1 (de) 2021-03-05 2022-09-07 Midas Pharma GmbH Stabile orale pharmazeutische zusammensetzungen mit fester dosis und sofortiger freisetzung mit amlodipin, atorvastatin und candesartan cilexetil
WO2023285646A1 (en) 2021-07-15 2023-01-19 Adamed Pharma S.A A pharmaceutical composition comprising amlodipine, candesartan cilexetil and hydrochlorothiazide for the treatment of hypertension
CN114149414B (zh) * 2021-12-23 2023-08-04 浙江永宁药业股份有限公司 一种利用微反应器连续流制备坎地沙坦的方法
WO2024075017A1 (en) 2022-10-04 2024-04-11 Zabirnyk Arsenii Inhibition of aortic valve calcification

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526896A (en) * 1978-12-26 1985-07-02 Riker Laboratories, Inc. Tetrazol-5-yl 2-nitro-3-phenylbenzofurans and antimicrobial use thereof
JPS5671073A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd Imidazole derivative
JPS5671074A (en) * 1979-11-12 1981-06-13 Takeda Chem Ind Ltd 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
US4775679A (en) * 1985-04-25 1988-10-04 Merck & Co., Inc. Certain heterocyclic-ethyl-2,3-dihydrobenzofurans useful as anti-inflammatory agents
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4764623A (en) * 1987-06-15 1988-08-16 American Home Products Corporation N-(1H-tetrazol-5-yl-alkylphenyl)polyfluoroalkanamides
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
CA2016710A1 (en) * 1989-05-15 1990-11-15 Prasun K. Chakravarty Substituted benzimidazoles as angiotensin ii antagonists
GB8911854D0 (en) * 1989-05-23 1989-07-12 Ici Plc Heterocyclic compounds
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
US5250554A (en) * 1989-10-24 1993-10-05 Takeda Chemical Industries, Ltd. Benzimidazole derivatives useful as angiotensin II inhibitors
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof

Also Published As

Publication number Publication date
AU7533191A (en) 1991-11-21
FI911936A0 (fi) 1991-04-22
DE19875004I2 (de) 2002-03-28
JPH04364171A (ja) 1992-12-16
DE69123784D1 (de) 1997-02-06
KR100200541B1 (ko) 1999-06-15
DK0459136T3 (da) 1997-04-01
FI911936A (fi) 1991-10-28
EP0720982B1 (de) 2002-11-13
LV10258A (lv) 1994-10-20
ATE227709T1 (de) 2002-11-15
PT97451B (pt) 1997-01-31
NO970195L (no) 1997-01-16
HU911347D0 (en) 1991-10-28
NO300923B1 (no) 1997-08-18
GR3022172T3 (en) 1997-03-31
CA2040955C (en) 1998-02-03
DE69133149D1 (de) 2002-12-19
NZ237949A (en) 1995-07-26
NL970044I1 (nl) 1998-03-02
HK1000803A1 (en) 1998-05-01
CN1147515A (zh) 1997-04-16
ES2095266T3 (es) 1997-02-16
CN1055927A (zh) 1991-11-06
NO911586L (no) 1991-10-28
EP0720982A1 (de) 1996-07-10
HU210871A9 (en) 1995-08-28
JP2514282B2 (ja) 1996-07-10
US5705517A (en) 1998-01-06
LU90224I2 (fr) 1998-05-11
DK0720982T3 (da) 2003-03-17
AU647469B2 (en) 1994-03-24
CA2040955A1 (en) 1991-10-28
ATE146779T1 (de) 1997-01-15
DE69123784T2 (de) 1997-04-17
HU213266B (en) 1997-04-28
US5196444A (en) 1993-03-23
US5401764A (en) 1995-03-28
LV10258B (en) 1995-04-20
CN1048486C (zh) 2000-01-19
CA2204290A1 (en) 1991-10-28
CN1058966C (zh) 2000-11-29
CA2204290C (en) 2001-12-18
JPH0899960A (ja) 1996-04-16
FI982761A0 (fi) 1998-12-21
PT97451A (pt) 1992-01-31
JP2853611B2 (ja) 1999-02-03
US5328919A (en) 1994-07-12
NO970195D0 (no) 1997-01-16
CY2150B1 (en) 2002-08-23
FI108434B (fi) 2002-01-31
IE911317A1 (en) 1991-11-06
HUT57736A (en) 1991-12-30
NL970044I2 (nl) 1998-06-02
FI982761A (fi) 1998-12-21
NO302752B1 (no) 1998-04-20
KR910018359A (ko) 1991-11-30
NO911586D0 (no) 1991-04-22
FI114983B (fi) 2005-02-15
EP0459136A1 (de) 1991-12-04
NO1998018I1 (no) 1998-06-25
ES2181742T3 (es) 2003-03-01
EP0459136B1 (de) 1996-12-27

Similar Documents

Publication Publication Date Title
DE69133149D1 (de) Benzimidazolderivate, ihre Herstellung und Verwendung als Angiotensin II-Antagonisten
DE69329727D1 (de) Neue imidazol derivate, ihre herstellung und therapeutische verwendung
TR199701218T2 (xx) Benzimidazol bile�ikleri ve bunlar� i�eren farmakolojik bile�imler.
AR052330A1 (es) Derivados de adamantano que comprenden quinoleinas sustituidas
KR920006335A (ko) 안지오텐신 ⅱ수용체 길항제
ATE202102T1 (de) 5-arylindol-derivate und ihre verwendung als serotonin (5-ht1)-agonisten
KR920008032A (ko) 인돌- 및 벤즈이미다졸-치환 이미다졸 및 벤즈이미다졸 유도체
TR199701219T1 (xx) Benzimidazol bile�ikleri, bu bile�ikleri i�eren ispen�iyar� bile�ikler.
FI945319A (fi) Substituoidut indolit ja atsaindolit angiotensiini II:n antagonisteina
ATE92062T1 (de) Heterocyclische guanidine als 5ht-3-antagonisten.
NZ515216A (en) UV-absorbers with an affinity for textile fibres

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP