DE69133329D1 - Markierte Oligonukleotide - Google Patents

Markierte Oligonukleotide

Info

Publication number
DE69133329D1
DE69133329D1 DE69133329T DE69133329T DE69133329D1 DE 69133329 D1 DE69133329 D1 DE 69133329D1 DE 69133329 T DE69133329 T DE 69133329T DE 69133329 T DE69133329 T DE 69133329T DE 69133329 D1 DE69133329 D1 DE 69133329D1
Authority
DE
Germany
Prior art keywords
nucleic acid
sequence variants
labeled oligonucleotides
identify
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69133329T
Other languages
English (en)
Other versions
DE69133329T2 (de
DE69133329T3 (de
Inventor
David H Gelfand
M Holland
K Saiki
M Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24251781&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69133329(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69133329D1 publication Critical patent/DE69133329D1/de
Publication of DE69133329T2 publication Critical patent/DE69133329T2/de
Publication of DE69133329T3 publication Critical patent/DE69133329T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
DE69133329T 1990-08-06 1991-08-06 Markierte Oligonukleotide Expired - Lifetime DE69133329T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/563,758 US5210015A (en) 1990-08-06 1990-08-06 Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US563758 1990-08-06

Publications (3)

Publication Number Publication Date
DE69133329D1 true DE69133329D1 (de) 2003-11-20
DE69133329T2 DE69133329T2 (de) 2004-08-05
DE69133329T3 DE69133329T3 (de) 2009-07-09

Family

ID=24251781

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69133574T Expired - Lifetime DE69133574T2 (de) 1990-08-06 1991-08-06 Verfahren zur Unterscheidung von Sequenz Varianten
DE69132521T Expired - Lifetime DE69132521T3 (de) 1990-08-06 1991-08-06 Homogenes testsystem
DE69133329T Expired - Lifetime DE69133329T3 (de) 1990-08-06 1991-08-06 Markierte Oligonukleotide

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69133574T Expired - Lifetime DE69133574T2 (de) 1990-08-06 1991-08-06 Verfahren zur Unterscheidung von Sequenz Varianten
DE69132521T Expired - Lifetime DE69132521T3 (de) 1990-08-06 1991-08-06 Homogenes testsystem

Country Status (10)

Country Link
US (6) US5210015A (de)
EP (3) EP0543942B2 (de)
JP (1) JP2825976B2 (de)
AT (3) ATE252110T1 (de)
AU (1) AU666837B2 (de)
CA (1) CA2088683C (de)
DE (3) DE69133574T2 (de)
DK (3) DK1302549T3 (de)
ES (3) ES2209033T5 (de)
WO (1) WO1992002638A1 (de)

Families Citing this family (1328)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635347A (en) * 1986-04-30 1997-06-03 Igen, Inc. Rapid assays for amplification products
US5795762A (en) * 1986-08-22 1998-08-18 Roche Molecular Systems, Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5466591A (en) * 1986-08-22 1995-11-14 Hoffmann-La Roche Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US6589734B1 (en) 1989-07-11 2003-07-08 Gen-Probe Incorporated Detection of HIV
US5856088A (en) * 1989-07-11 1999-01-05 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6872816B1 (en) * 1996-01-24 2005-03-29 Third Wave Technologies, Inc. Nucleic acid detection kits
DE69233391D1 (de) * 1991-11-07 2004-09-02 Nanotronics Inc Hybridisierung von mit Chromophoren und Fluorophoren konjugierten Polynukleotiden zur Erzeugung eines Donor-Donor Energietransfersystems
US5567583A (en) * 1991-12-16 1996-10-22 Biotronics Corporation Methods for reducing non-specific priming in DNA detection
US6033854A (en) * 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
NZ245720A (en) * 1992-01-22 1995-12-21 Hoechst Ag Oligonucleotide analogues; use as gene expression inhibitor or dna probe
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
US6033909A (en) * 1992-01-22 2000-03-07 Hoechst Aktiengesellschaft Oligonucleotide analogs, their preparation and use
JP3516953B2 (ja) * 1992-08-03 2004-04-05 アボツト・ラボラトリーズ エキソヌクレオリチック活性を用いた標的核酸の検出及び増幅
DE4239531A1 (de) * 1992-11-25 1994-05-26 Gabor Dr Igloi Reagenz zur Kupplung verschiedener Substanzen an Nukleinsäuren sowie Verfahren zu dessen Herstellung
US5843654A (en) * 1992-12-07 1998-12-01 Third Wave Technologies, Inc. Rapid detection of mutations in the p53 gene
US6673616B1 (en) 1992-12-07 2004-01-06 Third Wave Technologies, Inc. Methods and compositions for characterizing nucleic acids
US6372424B1 (en) * 1995-08-30 2002-04-16 Third Wave Technologies, Inc Rapid detection and identification of pathogens
US5888780A (en) * 1992-12-07 1999-03-30 Third Wave Technologies, Inc. Rapid detection and identification of nucleic acid variants
US7691573B2 (en) * 1992-12-07 2010-04-06 Third Wave Technologies, Inc. Cleavage of nucleic acids
US5541311A (en) * 1992-12-07 1996-07-30 Third Wave Technologies, Inc. Nucleic acid encoding synthesis-deficient thermostable DNA polymerase
US5614402A (en) * 1992-12-07 1997-03-25 Third Wave Technologies, Inc. 5' nucleases derived from thermostable DNA polymerase
US5422253A (en) * 1992-12-07 1995-06-06 Wisconsin Alumni Research Foundation Method of site specific nucleic acid cleavage
US5719028A (en) * 1992-12-07 1998-02-17 Third Wave Technologies Inc. Cleavase fragment length polymorphism
US20060084092A1 (en) * 1993-01-05 2006-04-20 Gelfand David H Homogeneous assay system
JP3099853B2 (ja) * 1993-02-19 2000-10-16 株式会社日立製作所 核酸の測定試薬及び測定方法
WO1994023069A1 (en) 1993-03-26 1994-10-13 Gen-Probe Incorporated Detection of human immunodeficiency virus type 1
US5491086A (en) * 1993-05-14 1996-02-13 Hoffmann-La Roche Inc. Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
DE4344742A1 (de) * 1993-06-09 1994-12-15 Boehringer Mannheim Gmbh Verfahren zur Immobilisierung von Nukleinsäuren
JPH0723800A (ja) * 1993-07-08 1995-01-27 Tanabe Seiyaku Co Ltd 核酸の検出方法
US6576419B1 (en) * 1993-07-23 2003-06-10 University Of Utah Research Foundation Assay procedure using fluorogenic tracers
DE69429038T2 (de) * 1993-07-28 2002-03-21 Pe Corp Ny Norwalk Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
US5645801A (en) * 1993-10-21 1997-07-08 Abbott Laboratories Device and method for amplifying and detecting target nucleic acids
JP3741439B2 (ja) * 1993-10-21 2006-02-01 アボット・ラボラトリーズ 流体サンプルの移送装置及び方法
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US6821727B1 (en) 1993-11-15 2004-11-23 Applera Corporation Hybridization assay using self-quenching fluorescence probe
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
WO1995014106A2 (en) * 1993-11-17 1995-05-26 Id Biomedical Corporation Cycling probe cleavage detection of nucleic acid sequences
DE69432919T2 (de) * 1993-12-28 2004-05-27 Tanabe Seiyaku Co., Ltd. Verfahren für den Nachweis spezifischer Polynukleotiden
US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US5869255A (en) 1994-02-01 1999-02-09 The Regents Of The University Of California Probes labeled with energy transfer couples dyes exemplified with DNA fragment analysis
US5547861A (en) * 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
AU698953B2 (en) * 1994-04-29 1998-11-12 Applied Biosystems, Llc System for real time detection of nucleic acid amplification products
WO1995032306A1 (en) * 1994-05-23 1995-11-30 Biotronics Corporation Method for detecting a target nucleic acid
ATE220424T1 (de) * 1994-05-28 2002-07-15 Tepnel Medical Ltd Herstellung von nukleinsaeurekopien
US5773213A (en) * 1994-06-06 1998-06-30 Brigham & Women's Hospital Method for conducting sequential nucleic acid hybridization steps
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US5580730A (en) * 1994-08-19 1996-12-03 Olympus America, Inc. Enzyme digestion method for the detection of amplified DNA
US5491063A (en) * 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
EP0788557A4 (de) * 1994-11-09 2003-08-06 Third Wave Tech Inc Schneller nachweis und identifizierung von nukleinsäure varianten und pathogenen
US5512441A (en) * 1994-11-15 1996-04-30 American Health Foundation Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US5571673A (en) * 1994-11-23 1996-11-05 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5786139A (en) * 1994-12-09 1998-07-28 Panvera Corporation Method and kit for detecting nucleic acid cleavage utilizing a covalently attached fluorescent tag
EP1260593A3 (de) * 1994-12-23 2003-12-03 Dade Behring Inc. Nachweis von Nukleinsäuren durch Nuklease-katalysierte Produktbildung
US6787304B1 (en) 1994-12-28 2004-09-07 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
WO1996021144A1 (en) * 1994-12-30 1996-07-11 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
US20030165908A1 (en) * 1994-12-30 2003-09-04 Georgetown University Fluorometric assay for detecting nucleic acid cleavage
CN1100258C (zh) * 1995-02-02 2003-01-29 中外制药株式会社 以调节化学发光为手段分析被分析物的方法
US5801155A (en) * 1995-04-03 1998-09-01 Epoch Pharmaceuticals, Inc. Covalently linked oligonucleotide minor grove binder conjugates
US6312894B1 (en) 1995-04-03 2001-11-06 Epoch Pharmaceuticals, Inc. Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
ATE196322T1 (de) * 1995-05-05 2000-09-15 Perkin Elmer Corp Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
KR100463475B1 (ko) 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
US5994063A (en) * 1995-06-23 1999-11-30 Metzker; Michael L. Substituted 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene compounds for homogenous amplification/detection assays
US6027879A (en) * 1995-08-09 2000-02-22 The Regents Of The University Of California Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe
WO1997010056A2 (en) * 1995-09-12 1997-03-20 Becton Dickinson And Company Device and method for dna amplification and assay
US5837442A (en) 1995-11-29 1998-11-17 Roche Molecular Systems, Inc. Oligonucleotide primers for amplifying HCV nucleic acid
DE19548680A1 (de) * 1995-12-23 1997-06-26 Boehringer Mannheim Gmbh Verfahren zum quantitativen Nachweis von spezifischen Nukleinsäuresequenzen
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
CA2243989A1 (en) * 1996-01-23 1997-07-31 Rapigene, Inc. Methods and compositions for detecting binding of ligand pair using non-fluorescent label
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6913881B1 (en) 1996-01-24 2005-07-05 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US6562611B1 (en) 1996-11-29 2003-05-13 Third Wave Technologies, Ins. FEN-1 endonucleases, mixtures and cleavage methods
US7256020B2 (en) * 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
ATE414793T1 (de) * 1996-01-24 2008-12-15 Third Wave Tech Inc Invasive spaltung von nukleinsäuren
US7122364B1 (en) * 1998-03-24 2006-10-17 Third Wave Technologies, Inc. FEN endonucleases
US7527928B2 (en) * 1996-11-29 2009-05-05 Third Wave Technologies, Inc. Reactions on a solid surface
US6875572B2 (en) 1996-01-24 2005-04-05 Third Wave Technologies, Inc. Nucleic acid detection assays
US6090606A (en) * 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US7432048B2 (en) * 1996-11-29 2008-10-07 Third Wave Technologies, Inc. Reactions on a solid surface
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US7195871B2 (en) * 1996-01-24 2007-03-27 Third Wave Technologies, Inc Methods and compositions for detecting target sequences
US20080160524A1 (en) * 1996-01-24 2008-07-03 Third Wave Technologies, Inc. Methods and Compositions for Detecting Target Sequences
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US5763184A (en) 1996-01-30 1998-06-09 Roche Molecular Systems, Inc. Nucleotide sequence variation in the ABO glycosyltransferase gene
US5716784A (en) * 1996-02-05 1998-02-10 The Perkin-Elmer Corporation Fluorescence detection assay for homogeneous PCR hybridization systems
US5874216A (en) 1996-02-23 1999-02-23 Ensys Environmental Products, Inc. Indirect label assay device for detecting small molecules and method of use thereof
CA2246238A1 (en) * 1996-03-01 1997-09-04 E.I. Du Pont De Nemours And Company A method for the amplification and detection of a nucleic acid fragment of interest
CA2199213C (en) 1996-03-11 2007-04-17 John Wesley Backus Amplifying and detecting target nucleic acids using a post amplification incubation step
US7244622B2 (en) 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
CA2252048C (en) * 1996-04-12 2008-03-11 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
AU2735797A (en) * 1996-04-12 1998-03-26 Public Health Research Institute Of The City Of New York, Inc., The Detection probes, kits and assays
US5955268A (en) * 1996-04-26 1999-09-21 Abbott Laboratories Method and reagent for detecting multiple nucleic acid sequences in a test sample
US5887385A (en) 1996-05-28 1999-03-30 Rite-Hite Holding Corporation Release mechanism for industrial doors
CA2591550C (en) 1996-06-04 2009-04-28 University Of Utah Research Foundation Monitoring hybridization during pcr
ES2434258T3 (es) * 1996-06-04 2013-12-16 University Of Utah Research Foundation Aparato para llevar a cabo la PCR y monitorización de la reacción en tiempo real durante ciclos de temperatura
US5736333A (en) * 1996-06-04 1998-04-07 The Perkin-Elmer Corporation Passive internal references for the detection of nucleic acid amplification products
US6780982B2 (en) * 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
DE69736667T2 (de) * 1996-07-16 2007-09-06 Gen-Probe Inc., San Diego Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5866336A (en) * 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5853990A (en) * 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
US6361940B1 (en) 1996-09-24 2002-03-26 Qiagen Genomics, Inc. Compositions and methods for enhancing hybridization and priming specificity
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050153373A1 (en) * 1996-10-31 2005-07-14 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20030165971A1 (en) * 1996-10-31 2003-09-04 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US5840879A (en) * 1996-12-06 1998-11-24 Wang; Edge R. Reagents and solid supports for improved synthesis and labeling of polynucleotides
US20020137904A1 (en) * 1998-03-27 2002-09-26 Patricia A. Billing-Medel Reagents and methods useful for detecting diseases of the gastrointestinal tract
US20050208567A1 (en) * 1997-04-25 2005-09-22 Billing-Medel Patricia A Reagents and methods useful for detecting diseases of the prostate
JP3948503B2 (ja) * 1997-08-01 2007-07-25 誠 鶴岡 蛍光偏光法による核酸の測定方法およびＶｅｒｏ毒素生産菌の検出方法
JP3174751B2 (ja) * 1997-09-30 2001-06-11 財団法人 東京都医学研究機構 リアルタイム検出ｐｃｒ法によるｈｃｖ遺伝子の測定方法並びにそれに用いられるプライマー及びプローブ
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
AU1366299A (en) * 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US6077669A (en) * 1997-11-04 2000-06-20 Becton Dickinson And Company Kit and method for fluorescence based detection assay
JP2002509694A (ja) 1997-11-04 2002-04-02 ロシュ ダイアグノスティックス ゲーエムベーハー 特異的かつ高感度な核酸検出方法
US6294326B1 (en) * 1997-11-07 2001-09-25 Abbott Laboratories Analyte detection process using dual labeled probes
US6583168B1 (en) 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
DE19752898A1 (de) 1997-11-28 1999-08-05 Centeon Pharma Gmbh Verfahren zum Nachweis hoher Vierenkonzentrationen im Blutplasma und/oder Blutserum mittels der Polymerasekettenreaktion
DE19755642B4 (de) * 1997-12-15 2005-03-10 Zlb Behring Gmbh Markierter Primer für die Polymerasekettenreaktion
DE69838210T2 (de) * 1997-12-15 2008-05-15 Csl Behring Gmbh Markierter Primer, geeignet für die Detektion von Nukleinsäuren
CA2318880C (en) * 1998-02-04 2010-07-27 Perkin-Elmer Corporation Determination of a genotype of an amplification product at multiple allelic sites
WO1999040219A1 (en) * 1998-02-05 1999-08-12 Bavarian Nordic Research Institute A/S Quantification by inhibition of amplification
WO1999049293A2 (en) 1998-03-24 1999-09-30 Boston Probes, Inc. Methods, kits and compositions pertaining to detection complexes
US5952202A (en) * 1998-03-26 1999-09-14 The Perkin Elmer Corporation Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification
US7045610B2 (en) * 1998-04-03 2006-05-16 Epoch Biosciences, Inc. Modified oligonucleotides for mismatch discrimination
US6127121A (en) * 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
US6683173B2 (en) * 1998-04-03 2004-01-27 Epoch Biosciences, Inc. Tm leveling methods
US6949367B1 (en) 1998-04-03 2005-09-27 Epoch Pharmaceuticals, Inc. Modified oligonucleotides for mismatch discrimination
US7715989B2 (en) * 1998-04-03 2010-05-11 Elitech Holding B.V. Systems and methods for predicting oligonucleotide melting temperature (TmS)
GB9808145D0 (en) * 1998-04-17 1998-06-17 Zeneca Ltd Assay
US20030203394A1 (en) * 1998-05-04 2003-10-30 Yoav Eichen Detection of a target in a sample
DE19822108A1 (de) * 1998-05-12 2000-02-03 Schering Ag Verfahren zur Detektion von Mikroorganismen in Produkten, insbesondere in Arzneimitteln und Kosmetika
US6468743B1 (en) 1998-05-18 2002-10-22 Conagra Grocery Products Company PCR techniques for detecting microbial contaminants in foodstuffs
DE19824535A1 (de) 1998-06-03 1999-12-09 Roche Diagnostics Gmbh Neue Rhodamin-Derivate und deren Verwendung
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
JP4349545B2 (ja) 1998-06-17 2009-10-21 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション Ｆｙ７ポリメラーゼ
EP1092047B1 (de) * 1998-07-02 2009-08-26 Gen-Probe Incorporated Molekulare fackeln
JP3437094B2 (ja) * 1998-07-03 2003-08-18 松下電器産業株式会社 多波長蛍光偏光法
US20040203078A1 (en) * 1998-07-22 2004-10-14 National Institute Of Advanced Industrial Science And Technology Labeled complex, process for producing same and process for utilizing same
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
IL126776A (en) * 1998-10-27 2001-04-30 Technion Res & Dev Foundation A method of investing gold
US6492111B1 (en) * 1998-11-25 2002-12-10 Isis Pharmaceuticals, Inc. In situ binary synthesis of biologically effective molecules
US6441152B1 (en) * 1998-12-08 2002-08-27 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
EP1013775A1 (de) * 1998-12-21 2000-06-28 LUTZ, Hans Quantitative Polymerase-Kettenreaktion mittels fluorogenen Echtzeiterfassungssystem
US6432642B1 (en) * 1999-01-15 2002-08-13 Pe Corporation (Ny) Binary probe and clamp composition and methods for a target hybridization detection
DE19906169A1 (de) * 1999-02-08 2000-08-10 Bioinside Ges Fuer Biodiagnost Testkit und Verfahren zum quantitativen Nachweis von gentechnisch veränderter DNS in Lebensmitteln mittels fluoreszenzgekoppelter PCR
US7141417B1 (en) * 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US6322980B1 (en) 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
GB9908437D0 (en) * 1999-04-13 1999-06-09 Minton Treharne & Davies Limit Methods of marking materials
US6573047B1 (en) 1999-04-13 2003-06-03 Dna Sciences, Inc. Detection of nucleotide sequence variation through fluorescence resonance energy transfer label generation
DE29906582U1 (de) * 1999-04-14 2000-09-21 Langenbach Guido Crashschutzvorrichtung
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
US6180349B1 (en) 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number
DE19923168A1 (de) 1999-05-20 2000-11-23 Roche Diagnostics Gmbh Neue Fluoreszenzfarbstoffe und ihre Verwendung als Fluoreszenzmarker
DE60040912D1 (de) * 1999-05-24 2009-01-08 Invitrogen Corp Ein verfahren zum entschützen markierter oligonukleotide
US6277607B1 (en) 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
US7097973B1 (en) 1999-06-14 2006-08-29 Alpha Mos Method for monitoring molecular species within a medium
WO2000079009A2 (en) 1999-06-22 2000-12-28 Invitrogen Corporation Improved primers and methods for the detection and discrimination of nucleic acids
WO2000078942A1 (en) * 1999-06-23 2000-12-28 Genesource, Inc. Non-destructive cell-based assay
US6750357B1 (en) 1999-06-25 2004-06-15 Syngen, Inc. Rhodamine-based fluorophores useful as labeling reagents
US6692834B1 (en) * 1999-06-28 2004-02-17 Medtronic, Inc. Method for coating implantable devices
US6830902B1 (en) * 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6339147B1 (en) 1999-07-29 2002-01-15 Epoch Biosciences, Inc. Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids
CA2384407C (en) 1999-08-30 2009-10-20 Roche Diagnostics Gmbh 2-azapurine compounds and their use
DE50001774D1 (de) 1999-09-29 2003-05-22 Tecan Trading Ag Maennedorf Thermocycler sowie Hebeelement für Mikrotiterplatte
GB9923144D0 (en) * 1999-09-30 1999-12-01 Socrates Biotech International Methods
US20030082616A1 (en) * 1999-10-15 2003-05-01 Hitachi, Ltd. Apparatus and method for analyzing nucleic acids and related genetic abnormality
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
WO2001031062A1 (en) * 1999-10-22 2001-05-03 The Public Health Research Institute Of The City Of New York, Inc. Assays for short sequence variants
US7381532B2 (en) * 1999-10-29 2008-06-03 Stratagene California Compositions and methods for the detection of a nucleic acid using a cleavage reaction
US7118860B2 (en) 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US7838225B2 (en) * 1999-10-29 2010-11-23 Hologic, Inc. Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
US6893819B1 (en) * 2000-11-21 2005-05-17 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US7824859B2 (en) * 1999-10-29 2010-11-02 Cytyc Corporation Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US7534568B2 (en) 1999-10-29 2009-05-19 Hologic Inc. Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
EP1233976A4 (de) * 1999-11-17 2003-06-11 Jiuping Ji Simultaner nachweis von hbv, hcv und hiv in plasmaproben mit hilfe eines multiplexen fixierungstests
SK287932B6 (sk) * 1999-11-17 2012-05-03 Roche Diagnostics Gmbh Magnetic glass particles, method for their preparation and uses thereof
US6660845B1 (en) 1999-11-23 2003-12-09 Epoch Biosciences, Inc. Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
WO2001038585A2 (en) * 1999-11-24 2001-05-31 The Regents Of The University Of California Polymer arrays and methods of using labeled probe molecules to identify and quantify target molecule expression
WO2001040520A1 (en) 1999-12-02 2001-06-07 Dna Sciences, Inc. Methods for determining single nucleotide variations and genotyping
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
US7205105B2 (en) * 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US20040081959A9 (en) * 1999-12-08 2004-04-29 Epoch Biosciences, Inc. Fluorescent quenching detection reagents and methods
US7250252B2 (en) * 1999-12-30 2007-07-31 David Aaron Katz Amplification based polymorphism detection
WO2001055438A1 (en) 2000-01-26 2001-08-02 University Of Cincinnati Detection of nucleic acid target sequences by electron paramagnetic resonance spectroscopy
DE10004147A1 (de) * 2000-01-31 2001-08-09 Gsf Forschungszentrum Umwelt Oligonukleotide zur spezifischen Amplifikation und zum spezifischen Nachweis von 16S-rRNA-Genen von Bakterien
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
FI20000333A0 (fi) * 2000-02-16 2000-02-16 Jussi Nurmi Homogeeninen menetelmä polynukleotidin havaitsemiseksi
AU4162101A (en) * 2000-02-23 2001-09-03 Hope City Pyrophosphorolysis activated polymerization (pap): application to allele-specific amplification and nucleic acid sequence determination
US7033763B2 (en) * 2000-02-23 2006-04-25 City Of Hope Pyrophosphorolysis activated polymerization (PAP)
US20030117705A1 (en) * 2000-02-25 2003-06-26 Cambridge Research & Instrumentation Inc. Fluorescence polarization assay system and method
JP2003525292A (ja) 2000-03-01 2003-08-26 エポック・バイオサイエンシーズ・インコーポレイテッド ミスマッチ識別のための修飾オリゴヌクレオチド
EP1944310A3 (de) 2000-03-01 2008-08-06 Epoch Biosciences, Inc. Modifizierte Oligonukleotide zur Erkennung von Fehlanpassungen
US7129045B2 (en) * 2000-03-23 2006-10-31 Lumigen, Inc. Methods of detecting polynucleotide kinase and its use as a label
EP1950313A3 (de) 2000-03-27 2010-12-08 GlaxoSmithKline LLC Detektion von lebensfähigen Agenzien
US7998673B2 (en) * 2000-03-29 2011-08-16 Lgc Limited Hybridisation beacon and method of rapid sequence detection and discrimination
US7211381B1 (en) 2000-04-04 2007-05-01 Abbott Laboratories β2 andrenergic polymorphism detection
US6593092B2 (en) 2000-04-04 2003-07-15 Abbott Laboratories Beta 2 adrenergic polymorphism detection
US20040067498A1 (en) * 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
EP1349954B1 (de) * 2000-05-19 2011-01-26 Eragen Biosciences, Inc. Materialien und methoden zum nachweis von nukleinsäuren
US6355433B1 (en) 2000-06-02 2002-03-12 Dna Sciences, Inc. Determination of nucleotide sequence variations through limited primer extension
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US6719949B1 (en) 2000-06-29 2004-04-13 Applera Corporation Apparatus and method for transporting sample well trays
WO2002004122A2 (en) * 2000-07-07 2002-01-17 Helen Lee Improved stability of hybridisation interactions in dipstick assays
GB0016836D0 (en) * 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
ATE384731T1 (de) * 2000-08-03 2008-02-15 Hoffmann La Roche Nukleinsäurebindende verbindungen mit pyrazolo 3, 4-d pyrimidinanalogen von purin-2,6-diamin und ihre verwendung
US6358679B1 (en) 2000-08-24 2002-03-19 Pe Corporation (Ny) Methods for external controls for nucleic acid amplification
AU2001291513B2 (en) * 2000-10-03 2007-06-07 Id+Plus Ltd Nucleotide detection method
AUPR050700A0 (en) * 2000-10-03 2000-10-26 Id+Plus Ltd Detection method
JP2002369700A (ja) * 2000-10-11 2002-12-24 Internatl Reagents Corp 核酸分析方法
US6350580B1 (en) 2000-10-11 2002-02-26 Stratagene Methods for detection of a target nucleic acid using a probe comprising secondary structure
EP1358352B1 (de) * 2000-10-14 2009-02-11 Eragen Biosciences, Inc. Nachweissysteme auf festen trägern und methoden zur verwendung von nicht-standardbasen
NZ525336A (en) * 2000-10-20 2006-03-31 Expression Diagnostics Inc Leukocyte expression profiling
JP2002125687A (ja) * 2000-10-30 2002-05-08 Tosoh Corp Ｈｉｖ−１検出のためのオリゴヌクレオチドおよび検出法
CA2428798C (en) * 2000-11-15 2013-09-03 Third Wave Technologies, Inc. Fen-1 endonucleases from archaeoglobus veneficus
US7309573B2 (en) * 2000-11-21 2007-12-18 Stratagene California Methods for detection of a nucleic acid by sequential amplification
US7157232B2 (en) * 2000-12-13 2007-01-02 The Regents Of The University Of California Method to detect the end-point for PCR DNA amplification using an ionically labeled probe and measuring impedance change
US20020142336A1 (en) * 2001-02-02 2002-10-03 Genome Therapeutics Corporation Methods for determining a nucleotide at a specific location within a nucleic acid molecule
CN100351393C (zh) * 2001-02-15 2007-11-28 宝生物工程株式会社 核苷酸多态性的检测方法
EP1236804A1 (de) 2001-03-02 2002-09-04 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Nukleinsäuren mittels einer Kontrolle
US6713620B2 (en) * 2001-03-28 2004-03-30 Council Of Scientific And Industrial Research Oligonucleotide primers for phosphotidyl inositol in bacillus cereus
US7329223B1 (en) * 2001-05-31 2008-02-12 Abbott Cardiovascular Systems Inc. Catheter with optical fiber sensor
US7532920B1 (en) 2001-05-31 2009-05-12 Advanced Cardiovascular Systems, Inc. Guidewire with optical fiber
CA2348042A1 (en) 2001-06-04 2002-12-04 Ann Huletsky Sequences for detection and identification of methicillin-resistant staphylococcus aureus
US7235358B2 (en) * 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
WO2003002959A1 (en) * 2001-06-15 2003-01-09 Mj Research, Inc. Controller for a fluorometer
US9261460B2 (en) 2002-03-12 2016-02-16 Enzo Life Sciences, Inc. Real-time nucleic acid detection processes and compositions
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
EP1275735A1 (de) * 2001-07-11 2003-01-15 Roche Diagnostics GmbH Zusammensetzung und Methode zur 'Hot start' Nukleinsäureamplifizierung
AU2002365028A1 (en) * 2001-07-17 2003-06-30 Stratagene Methods for detection of a target nucleic acid using multi-subunit probes
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US6593091B2 (en) 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
US6942836B2 (en) * 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
WO2003033741A1 (en) * 2001-10-16 2003-04-24 Aclara Biosciences, Inc. Universal e-tag primer and probe compositions and methods
US6902900B2 (en) 2001-10-19 2005-06-07 Prolico, Llc Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
DE10153829A1 (de) * 2001-11-05 2003-05-28 Bayer Ag Assay basierend auf dotierten Nanoteilchen
CN1166422C (zh) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 用于体外高能聚焦超声波治疗机的坐位架
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
DE60235491D1 (de) 2001-11-28 2010-04-08 Bio Rad Laboratories Paralleles scoring von polymorphismen mittels amplifikation und fehlerkorrektur
WO2003048295A1 (en) 2001-11-30 2003-06-12 Fluidigm Corporation Microfluidic device and methods of using same
US7223538B2 (en) * 2001-12-14 2007-05-29 Ge Healthcare Bio-Sciences Ab Post-synthesis labeling of nucleic acids, assays using nucleic acids that are labeled post-synthetically, single nucleotide polymorphism detection, and associated compounds and microarrays
US7198897B2 (en) * 2001-12-19 2007-04-03 Brandeis University Late-PCR
JP4148900B2 (ja) 2002-01-08 2008-09-10 エフ．ホフマン−ラ ロシュ アーゲー 増幅反応におけるシリカ物質の使用
US7122314B2 (en) * 2002-01-30 2006-10-17 Id Biomedical Corporation Methods for detecting vancomycin-resistant microorganisms and compositions therefor
AU2003225629A1 (en) * 2002-02-27 2003-09-09 University Of Delaware Molecular markers for identification of fat and lean phenotypes in chickens
EP1340818A1 (de) * 2002-02-27 2003-09-03 Epigenomics AG Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US9353405B2 (en) 2002-03-12 2016-05-31 Enzo Life Sciences, Inc. Optimized real time nucleic acid detection processes
HUP0200981A3 (en) * 2002-03-14 2004-06-28 Genoid Kft Pcr reactions with hybridizing probes using primers with broad genotype-specificity for detection of human papilloma-viruses and typing amplificates by using specifically hybridizing oligonucleotides
EP1498486A4 (de) * 2002-03-29 2005-08-03 Prec System Science Co Ltd Nukleinsäurebibliothek und proteinbibliothek
US7445893B2 (en) * 2002-04-12 2008-11-04 Primera Biosystems, Inc. Sampling method for amplification reaction analysis
US7081339B2 (en) * 2002-04-12 2006-07-25 Primera Biosystems, Inc. Methods for variation detection
US7745180B2 (en) 2002-04-24 2010-06-29 Hitachi Chemical Co., Ltd. Device and method for high-throughput quantification of mRNA from whole blood
US7220544B2 (en) 2002-05-08 2007-05-22 Arkray, Inc. Method for detecting target nucleic acid
US20030219754A1 (en) * 2002-05-23 2003-11-27 Oleksy Jerome E. Fluorescence polarization detection of nucleic acids
ATE489477T1 (de) * 2002-06-28 2010-12-15 Primeradx Inc Verfahren zum nachweis von sequenzunterschieden
US6896727B2 (en) * 2002-06-28 2005-05-24 Seh America, Inc. Method of determining nitrogen concentration within a wafer
US20040023220A1 (en) * 2002-07-23 2004-02-05 Lawrence Greenfield Integrated method for PCR cleanup and oligonucleotide removal
FR2842827B1 (fr) * 2002-07-26 2004-10-22 Biocortech NOUVELLE METHODE D'ANALYSE D'ACIDE NUCLEIQUE ET SON UTILISATION POUR EVALUER LE DEGRE D'EDITION DE L'ARNm DU RECEPTEUR 5-HT2c
EP2385137A1 (de) 2002-07-31 2011-11-09 University of Southern California Polymorphismen zur Vorhersage des Krankheits- und Behandlungsausgangs
AU2003236461B2 (en) 2002-08-29 2009-05-28 Epigenomics Ag Improved method for bisulfite treatment
WO2004026804A1 (en) * 2002-09-20 2004-04-01 Integrated Dna Technologies, Inc. Anthraquinone quencher dyes, their methods of preparation and use
US7245789B2 (en) * 2002-10-07 2007-07-17 Vascular Imaging Corporation Systems and methods for minimally-invasive optical-acoustic imaging
US7807802B2 (en) 2002-11-12 2010-10-05 Abbott Lab Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
HUE033832T2 (en) 2002-11-15 2018-01-29 Idenix Pharmaceuticals Llc 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
FI113549B (fi) * 2002-11-19 2004-05-14 Mobidiag Oy Diagnostinen menetelmä hengitystieinfektioita aiheuttavien bakteerien osoittamiseksi ja tunnistamiseksi ja menetelmässä käyttökelpoinen alukeseos
US20050089875A1 (en) * 2002-11-21 2005-04-28 Sention Inc. Quantitative analysis of expression profiling information produced at various stages of an amplification process
CA2506797C (en) * 2002-11-22 2009-02-10 F.Hoffmann-La Roche Ag Detectable labeled nucleoside analogs and methods of use thereof
US20040248085A1 (en) * 2002-11-29 2004-12-09 Sang-Wha Lee General primers and process for detecting diverse genotypes of human papillomavirus by PCR
EP1594975A4 (de) 2002-12-04 2006-08-02 Applera Corp Multiplex-amplifikation von polynukleotiden
US7718361B2 (en) 2002-12-06 2010-05-18 Roche Molecular Systems, Inc. Quantitative test for bacterial pathogens
ES2326316T3 (es) * 2002-12-06 2009-10-07 Innogenetics N.V. Deteccion, identificacion y diferenciacion de taxones eubacteriales utilizando un ensayo de hibridacion.
ATE474933T1 (de) 2002-12-06 2010-08-15 Hoffmann La Roche Verfahren zum nachweis von pathogenen organismen
EP1426447A1 (de) * 2002-12-06 2004-06-09 Roche Diagnostics GmbH Verfahren zur Detection des pathogenen gram positiven Bacterien, Bvw. Staphylococcus, Enterococcus and Streptococcus
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
EP2500440B1 (de) 2002-12-20 2015-12-16 Celera Corporation Mit Myokardinfarkt assoziierte genetische Polymorphismen, Nachweisverfahren und deren Verwendungen
EP1585832B1 (de) * 2002-12-20 2008-02-13 Stratagene Zusammensetzungen und verfahren für den nachweis von polynukleotiden
US7560231B2 (en) * 2002-12-20 2009-07-14 Roche Molecular Systems, Inc. Mannitol and glucitol derivatives
DE602004018270D1 (de) * 2003-01-17 2009-01-22 Eragen Biosciences Inc Nukleinsäureamplifikation mit nichtstandardbasen
DE602004009038T3 (de) * 2003-01-29 2015-06-25 Roche Diagnostics Gmbh Verbessertes Verfahren zur Behandlung durch Bisulfit
JP2006522329A (ja) * 2003-03-07 2006-09-28 ラクセル・バイオサイエンシズ・リミテッド 酸素感受性プローブ
US20060192960A1 (en) * 2003-03-24 2006-08-31 Rencs Erik V Polarization detection
WO2004092412A2 (en) 2003-03-31 2004-10-28 Roche Diagnostics Gmbh Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup
AU2004227353B2 (en) * 2003-04-01 2010-02-25 Luminex Corporation Polymerase inhibitor and method of using same
EP2340890B1 (de) 2003-04-03 2016-10-19 Fluidigm Corporation Verfahren zur Durchführung von Digitaler PCR
CA2463719A1 (en) * 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
WO2004094986A2 (en) * 2003-04-16 2004-11-04 Handylab, Inc. System and method for electrochemical detection of biological compounds
US20040214176A1 (en) * 2003-04-22 2004-10-28 Osborne James C. Multiplexed DNA assays using structure-specific endonucleases
US7892745B2 (en) * 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US20070248978A1 (en) * 2006-04-07 2007-10-25 Expression Diagnostics, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
ES2305808T3 (es) 2003-05-20 2008-11-01 Bayer Healthcare Llc Diarilureas con actividad inhibidora de quinasas.
DE10327756B4 (de) * 2003-06-18 2005-12-29 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Verfahren zum Echtzeit-Quantifizieren einer Nukleinsäure
WO2005003373A2 (en) * 2003-06-26 2005-01-13 Proligo, Llc Fluorogenic nucleic acid probes including lna for methods to detect and/or quantify nucleic acid analytes
US20050233314A1 (en) * 2003-06-30 2005-10-20 National Health Research Institutes Sensitive and quantitative detection of pathogens by real-time nested PCR
GB0317592D0 (en) * 2003-07-26 2003-08-27 Astrazeneca Ab Method
KR101176191B1 (ko) 2003-07-29 2012-08-22 오츠카 세이야쿠 가부시키가이샤 약제 기인성 과립구 감소증 발증 리스크 판정법
EP1502961B1 (de) * 2003-08-01 2010-09-08 Roche Diagnostics GmbH Neues Format zur Detektion von Heissstart- und Echtzeit-Polymerasekettenreaktion
EP1502958A1 (de) * 2003-08-01 2005-02-02 Roche Diagnostics GmbH Neues Format zur Detektion von Heissstart- und Echtzeit-Polymerasekettenreaktion
WO2005028629A2 (en) * 2003-09-19 2005-03-31 Applera Corporation Whole genome expression analysis system
WO2005033328A2 (en) * 2003-09-30 2005-04-14 Perkinelmer Las, Inc. Compositions and processes for genotyping single nucleotide polymorphisms
US7348146B2 (en) * 2003-10-02 2008-03-25 Epoch Biosciences, Inc. Single nucleotide polymorphism analysis of highly polymorphic target sequences
CA2482097C (en) * 2003-10-13 2012-02-21 F. Hoffmann-La Roche Ag Methods for isolating nucleic acids
US7910296B2 (en) 2003-10-21 2011-03-22 Orion Genomics Llc Methods for quantitative determination of methylation density in a DNA locus
EP1680666A4 (de) * 2003-10-27 2008-03-26 Monogram Biosciences Inc Nachweisen von menschlichen antitherapeutischen antikörpern
PT1687609E (pt) * 2003-10-28 2015-03-02 Epoch Biosciences Inc Sondas fluorescentes para a detecção de adn por hibridação com uma maior sensibilidade e menor ruído de fundo
US20070128607A1 (en) * 2003-11-04 2007-06-07 Martin Dugas Method for distinguishing aml subtypes with different gene dosages
EP1682902A2 (de) * 2003-11-04 2006-07-26 Roche Diagnostics GmbH Methode zur unterscheidung von mll-ptd positiven aml von anderen aml subtypen
EP1682903A2 (de) * 2003-11-04 2006-07-26 Roche Diagnostics GmbH Methode zur unterscheidung zwischen aml-spezifischen flt3 längenmutationen und tkd mutationen
US20070212688A1 (en) * 2003-11-04 2007-09-13 Martin Dugas Method For Distinguishing Cbf-Positive Aml Subtypes From Cbf-Negative Aml Subtypes
US20070207459A1 (en) * 2003-11-04 2007-09-06 Martin Dugas Method For Distinguishing Immunologically Defined All Subtype
WO2005045435A2 (en) * 2003-11-04 2005-05-19 Roche Diagnostics Gmbh METHOD FOR DISTINGUISHING T(11q23)/MLL-POSITIVE LEUKEMIAS FROM T(11q23)MLL NEGATIVE LEUKEMIAS
WO2005043161A2 (en) * 2003-11-04 2005-05-12 Roche Diagnostics Gmbh Method for distinguishing leukemia subtypes
EP1530046A1 (de) * 2003-11-04 2005-05-11 Ludwig-Maximilians-Universität München Methode zur Unterscheidung von AML Subtypen mit verändertem Karyotyp mit mittelmässiger Prognose
US20070105118A1 (en) * 2003-11-04 2007-05-10 Martin Dugas Method for distinguishing aml subtypes with recurring genetic aberrations
EP1533618A1 (de) * 2003-11-04 2005-05-25 Ludwig-Maximilians-Universität München Methode zur Unterscheidung prognostisch definierbarer AML
US20050261841A1 (en) * 2003-11-07 2005-11-24 Shepard Donald F Physical geolocation system
EP1694855A4 (de) * 2003-11-12 2008-01-30 Bayer Healthcare Llc Oligonukleotide und verfahren zum nachweis des westnil-virus
WO2005049849A2 (en) 2003-11-14 2005-06-02 Integrated Dna Technologies, Inc. Fluorescence quenching azo dyes, their methods of preparation and use
JP2007534308A (ja) * 2003-11-19 2007-11-29 アレロジック・バイオサイエンシズ・コーポレーション 複数のフルオロフォアで標識したオリゴヌクレオチド
CA2832293C (en) 2003-11-26 2015-08-04 Celera Corporation Single nucleotide polymorphisms associated with cardiovascular disorders and statin response, methods of detection and uses thereof
US20050244847A1 (en) * 2003-11-26 2005-11-03 Eppendorf Ag Methods and compositions for in vitro amplification of extrachromosomal nucleic acid
JP4435174B2 (ja) 2003-12-02 2010-03-17 エフ．ホフマン−ラ ロシュ アーゲー 重亜硫酸塩処理の改良された方法
CA2494571C (en) * 2003-12-02 2010-02-09 F.Hoffmann-La Roche Ag Oligonucleotides containing molecular rods
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US8586357B2 (en) 2003-12-23 2013-11-19 Viacyte, Inc. Markers of definitive endoderm
US7704738B2 (en) 2003-12-23 2010-04-27 Cythera, Inc. Definitive endoderm
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
US8647873B2 (en) 2004-04-27 2014-02-11 Viacyte, Inc. PDX1 expressing endoderm
US20050208539A1 (en) * 2003-12-31 2005-09-22 Vann Charles S Quantitative amplification and detection of small numbers of target polynucleotides
WO2005067646A2 (en) 2004-01-07 2005-07-28 Hitachi Chemical Research Center, Inc. Primers and probes for the detection of hiv
ES2597841T3 (es) * 2004-02-06 2017-01-23 Fujirebio Europe N.V. Detección, identificación y diferenciación de especies de Proteus utilizando la región espaciadora
ATE485401T1 (de) * 2004-02-10 2010-11-15 Hoffmann La Roche Neue primer und sonden zum nachweis von parvovirus b19
EP1716252A1 (de) * 2004-02-19 2006-11-02 University College Cork-National University of Ireland, Cork Nachweis biologisch aktiver verbindungen
EP2208797A3 (de) 2004-03-01 2010-11-24 Applied Biosystems, LLC Verfahren, Zusammensetzungen und Kits für Polynukleotidamplifikation
WO2005092038A2 (en) * 2004-03-22 2005-10-06 The Johns Hopkins University Methods for the detection of nucleic acid differences
KR100906749B1 (ko) * 2004-03-25 2009-07-09 (주)바이오니아 인터컬레이팅 형광염료가 표지된 프로브를 이용한 핵산 증폭 측정 방법
WO2005098042A2 (en) * 2004-04-01 2005-10-20 Bio-Rad Laboratories, Inc. Quantitative amplification with a labeled probe and 3' to 5' exonuclease activity
EP1732614B1 (de) * 2004-04-08 2008-12-24 Sangamo Biosciences Inc. Zusammensetzungen zur behandlung von neuropathischen und neurodegenerativen erkrankungen
AU2005233583B2 (en) * 2004-04-08 2011-02-03 Sangamo Therapeutics, Inc. Methods and compositions for modulating cardiac contractility
CN101935709B (zh) 2004-04-26 2012-11-28 和光纯药工业株式会社 结核菌检测用的引物和探针以及使用它们检测人型结核菌的方法
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
CA2852855C (en) 2004-05-07 2016-07-05 Celera Corporation Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
JP4545147B2 (ja) * 2004-05-17 2010-09-15 株式会社日立国際電気 基板処理装置及び半導体デバイス製造方法
US20080261207A1 (en) * 2004-05-25 2008-10-23 Masato Mitsuhashi Method of Measuring Cancer Susceptibility
EP1758981A4 (de) * 2004-05-28 2013-01-16 Wafergen Inc Vorrichtungen und verfahren für multiplex-analysen
US7575863B2 (en) * 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
CN101793826B (zh) 2004-06-07 2016-04-13 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
CA2571243A1 (en) 2004-06-21 2006-01-05 The Board Of Trustees Of The Leland Stanford Junior University Genes and pathways differentially expressed in bipolar disorder and/or major depressive disorder
EP1609871A1 (de) * 2004-06-21 2005-12-28 Biolytix AG Verfahren und Kits zur Detektion, Identifizierung und Quantifizierung von Bacterien und Hefen in Lebensmitteln und Getränken.
US20070154889A1 (en) * 2004-06-25 2007-07-05 Veridex, Llc Methods and reagents for the detection of melanoma
US7745125B2 (en) 2004-06-28 2010-06-29 Roche Molecular Systems, Inc. 2′-terminator related pyrophosphorolysis activated polymerization
US20060216715A1 (en) * 2004-06-28 2006-09-28 Jun Nakayama Method of detecting cancer
WO2006000647A1 (en) * 2004-06-29 2006-01-05 Wallac Oy Integrated non-homogeneous nucleic acid amplification and detection
US7776530B2 (en) * 2004-06-29 2010-08-17 Wallac Oy Integrated nucleic acid analysis
US20060057611A1 (en) * 2004-06-30 2006-03-16 Applera Corporation Log-linear amplification
US7399614B2 (en) * 2004-06-30 2008-07-15 Applera Corporation 5-methylcytosine detection, compositions and methods therefor
AU2005267148A1 (en) 2004-07-01 2006-02-02 University Of Southern California Genetic markers for predicting disease and treatment outcome
TWI334885B (en) * 2004-07-05 2010-12-21 Food And Drug Administration Dept Of Health Primers, probes and reference plasmid for detection of meat
EP1767655A4 (de) 2004-07-13 2007-08-01 Takeda Pharmaceutical Verfahren zur steuerung von zellfuktionen
EP1627921B1 (de) * 2004-08-18 2008-08-27 Roche Diagnostics GmbH Verfahren zur Messung einer Nukleinsäureamplifikation in Real Time beinhaltend die Positionierung eines Reaktionsgefässes relativ zu einer Detektionseinheit
EP1632578A1 (de) * 2004-09-03 2006-03-08 Roche Diagnostics GmbH Methode zur Dekontamination der DNA
US7645575B2 (en) * 2004-09-08 2010-01-12 Xdx, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
EP1634965B1 (de) 2004-09-09 2010-01-20 Roche Diagnostics GmbH Echtzeit-PCR unter Zusatz von Pyrophosphatase
US20060051796A1 (en) * 2004-09-09 2006-03-09 Inga Boell Real time PCR with the addition of pyrophosphatase
US8969379B2 (en) 2004-09-17 2015-03-03 Eisai R&D Management Co., Ltd. Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide
EP2186908A1 (de) * 2004-09-21 2010-05-19 Applied Biosystems, LLC Zweifarbige Echtzeit/Endpunkt-Quantifizierung von Mikro-RNAs (miRNAs)
JP5210634B2 (ja) * 2004-09-30 2013-06-12 イノジェネティックス・ナムローゼ・フェンノートシャップ スペーサー領域を使用するセラチア（Ｓｅｒｒａｔｉａ）種の検出、同定および鑑別
US7166680B2 (en) * 2004-10-06 2007-01-23 Advanced Cardiovascular Systems, Inc. Blends of poly(ester amide) polymers
RU2460804C2 (ru) * 2004-10-18 2012-09-10 Брандейс Юнивесити Способ гомогенной детекции по меньшей мере одного продукта одноцепочечной амплификации
JP5165376B2 (ja) * 2004-10-18 2013-03-21 ブランデイズ ユニバーシティー Ｐｃｒ増幅での再現性の改善およびミスプライミングの低減のための試薬および方法
US20060147954A1 (en) * 2004-10-19 2006-07-06 Wallac Oy Novel probe and its use in bioaffinity assays
US20090011410A1 (en) * 2004-10-20 2009-01-08 Masato Mitsuhashi Method for tailoring administration of drugs by quantitation of mrna
CA2584489C (en) 2004-10-21 2014-07-22 Gsf-Forschungszentrum Fur Umwelt Und Gesundheit Gmbh Kaspp (lrrke) gene, its production and use for the detection and treatment of neurodegenerative disorders
CN100441696C (zh) * 2004-10-22 2008-12-10 中国疾病预防控制中心传染病预防控制所 肠出血性大肠杆菌o157：h7菌株的检测方法
AU2005299590B2 (en) 2004-10-27 2010-09-16 Cepheid Closed-system multi-stage nucleic acid amplification reactions
ES2364157T3 (es) 2004-10-28 2011-08-26 Otsuka Pharmaceutical Co., Ltd. Marcador de identificación sensible a la terapia con interferón para el cáncer de las células renales.
EP2280085A3 (de) 2004-11-01 2011-02-23 George Mason University Zusammensetzungen und Verfahren zur Diagnose von Kolonerkrankungen
US20090118132A1 (en) * 2004-11-04 2009-05-07 Roche Molecular Systems, Inc. Classification of Acute Myeloid Leukemia
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
EP1666150B1 (de) 2004-11-20 2015-01-07 Roche Diagnostics GmbH Präparieren von Nucleinsäuren
EP2270512B1 (de) * 2004-12-08 2016-03-23 Cedars-Sinai Medical Center Verfahren zur Diagnose von Morbus Crohn
WO2010048415A1 (en) * 2008-10-22 2010-04-29 Cedars-Sinai Medical Center Methods of using jak3 genetic variants to diagnose and predict crohn's disease
JP4190562B2 (ja) * 2004-12-08 2008-12-03 健 山本 遺伝子配列検査法
US7842794B2 (en) 2004-12-17 2010-11-30 Roche Molecular Systems, Inc. Reagents and methods for detecting Neisseria gonorrhoeae
US20060178507A1 (en) * 2004-12-30 2006-08-10 Berry & Associates, Inc. Fluorous oligonucleotide reagents and affinity purification of oligonucleotides
US20060252032A1 (en) * 2005-01-28 2006-11-09 Third Wave Technologies, Inc. Detection of human herpesviruses
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
WO2006094106A2 (en) * 2005-02-28 2006-09-08 Sangamo Biosciences, Inc. Anti-angiogenic methods and compositions
US7521188B2 (en) * 2005-03-02 2009-04-21 The Regents Of The University Of Michigan Optical monitoring of cleaving enzyme activity
US8008066B2 (en) 2005-03-10 2011-08-30 Gen-Probe Incorporated System for performing multi-formatted assays
EP1921454B1 (de) 2005-03-10 2015-08-12 Gen-Probe Incorporated Systeme und Verfahren zur Durchführung von Tests zum Nachweis oder zur Quantifizierung von Analyten
WO2006099365A2 (en) 2005-03-11 2006-09-21 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
US20070026423A1 (en) * 2005-03-16 2007-02-01 Thomas Koehler Method and test kit for the detection of target nucleic acids
US7776567B2 (en) 2005-03-17 2010-08-17 Biotium, Inc. Dimeric and trimeric nucleic acid dyes, and associated systems and methods
US7601498B2 (en) 2005-03-17 2009-10-13 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection and associated technology
WO2006101913A2 (en) * 2005-03-18 2006-09-28 Eragen Biosciences, Inc. Methods for detecting multiple species and subspecies of neiserria
EP1861512A4 (de) 2005-03-18 2009-12-09 Fluidigm Corp Wärmereaktionsvorrichtung und verwendungsverfahren dafür
EP1710016A3 (de) 2005-03-30 2011-03-30 Roche Diagnostics GmbH Vorrichtung mit selbstdichtendem Einlass
US20060275798A1 (en) * 2005-04-04 2006-12-07 Steichen John C Detection of organisms using a media sachet and primer directed nucleic acid amplification
GB2424886A (en) 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
JP4945554B2 (ja) * 2005-04-28 2012-06-06 ヒタチ ケミカル リサーチ センター インコーポレイテッド 食物サプリメントに対する個体変動評価のモデルとしての全血におけるｅｘｖｉｖｏ遺伝子発現
AU2006242201A1 (en) * 2005-05-02 2006-11-09 Stratagene California Oligonucleotide probe/primer compositions and methods for polynucleotide detection
EP1885889A4 (de) * 2005-05-11 2010-01-20 Expression Diagnostics Inc Verfahren zur überwachung des betriebsstatus von transplantaten über genlisten
ATE496996T1 (de) 2005-05-13 2011-02-15 Wako Pure Chem Ind Ltd Primer, sonden, verfahren und verwendungen davon zum nachweis von mycobacterium kansasii
AU2006251637B2 (en) * 2005-05-20 2012-06-14 Integrated Dna Technologies, Inc. Compounds and methods for labeling oligonucleotides
US7737281B2 (en) * 2005-05-24 2010-06-15 Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. Purine based fluorescent dyes
US7569695B2 (en) * 2005-05-24 2009-08-04 Enzo Life Sciences, Inc. Dyes for the detection or quantification of desirable target molecules
US8357801B2 (en) 2005-05-24 2013-01-22 Enzo Life Sciences, Inc. Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
US8362250B2 (en) 2005-05-24 2013-01-29 Enzo Biochem, Inc. Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
EP1893777B1 (de) 2005-06-07 2014-10-01 Luminex Corporation Verfahren zum nachweis und zur typisierung von nukleinsäuren
EP1964931B1 (de) * 2005-06-08 2010-12-29 Hitachi Chemical Research Center, Inc. Verfahren zur Vorhersage der Immunreaktion auf neoplastische Krankheiten auf der Grundlage des mRNA-Ausdrucksprofil in neoplastischen Zellen und stimulierten Leukozyten
CA2611507A1 (en) * 2005-06-09 2006-12-21 Epoch Biosciences, Inc. Improved primer-based amplification methods
US8053627B2 (en) * 2005-06-14 2011-11-08 University Of Chicago Methods for treating demyelination disorders
US7423194B2 (en) * 2005-06-14 2008-09-09 University Of Chicago Animal models for demyelination disorders
US7884260B2 (en) * 2005-06-14 2011-02-08 University Of Chicago Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination
CA2611743C (en) 2005-06-15 2019-12-31 Callida Genomics, Inc. Nucleic acid analysis by forming and tracking aliquoted fragments of a target polynucleotide
US20060292577A1 (en) * 2005-06-27 2006-12-28 Purdue Research Foundation Neoplasia-specific splice variants and methods
US20060292578A1 (en) * 2005-06-28 2006-12-28 Weidong Zheng DNA polymerase blends and mutant DNA polymerases
US7465561B2 (en) 2005-06-30 2008-12-16 Roche Molecular Systems, Inc. Probes and methods for hepatitis C virus typing using single probe analysis
WO2007008693A2 (en) * 2005-07-09 2007-01-18 Lovelace Respiratory Research Institute Gene methylation as a biomarker in sputum
US20070020671A1 (en) * 2005-07-12 2007-01-25 Radtkey Ray R Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes
US7977108B2 (en) * 2005-07-25 2011-07-12 Roche Molecular Systems, Inc. Method for detecting a mutation in a repetitive nucleic acid sequence
CA2617063C (en) 2005-07-26 2015-04-14 University Of Medicine And Dentistry Of New Jersey Assays for resistance to echinocandin-class drugs
EP1925676A4 (de) 2005-08-02 2010-11-10 Eisai R&D Man Co Ltd Testverfahren für die wirkung eines vaskularisierungsinhibitors
WO2007019410A2 (en) * 2005-08-05 2007-02-15 The Board Of Trustees Of The Leland Stanford Junior University Mammalian obestatin receptors
JP2009506759A (ja) * 2005-09-01 2009-02-19 コーベット ライフ サイエンス ピーティーワイ リミテッド 核酸の増幅、定量化、及び同定の方法。
DE602005021967D1 (de) 2005-09-06 2010-08-05 Roche Diagnostics Gmbh Vorrichtung mit komprimierbarer Matrix und homogenem Strömungsprofil
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
ES2371088T3 (es) * 2005-10-05 2011-12-27 F. Hoffmann-La Roche Ag Transferencia de energía no fluorescente.
EP1951900B1 (de) 2005-10-07 2016-06-15 Callida Genomics, Inc. Selbstzusammengesetzte einzelmolekül-arrays und verwendungen davon
US11834720B2 (en) 2005-10-11 2023-12-05 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx
US7838221B2 (en) 2005-10-11 2010-11-23 Geneohm Sciences, Inc. Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA)
US8831887B2 (en) * 2005-10-12 2014-09-09 The Research Foundation For The State University Of New York Absolute PCR quantification
US20070084706A1 (en) * 2005-10-18 2007-04-19 Shuichi Takayama Microfluidic cell culture device and method for using same
US20070092904A1 (en) * 2005-10-19 2007-04-26 Biogen Idec Ma Inc. Method for preparing limiting quantities of nucleic acids
US7781165B2 (en) 2005-10-19 2010-08-24 Roche Diagnostics Operations, Inc. Benzimidazolium compounds and salts of benzimidazolium compounds for nucleic acid amplification
ES2775049T3 (es) 2005-10-21 2020-07-23 Univ California Mutaciones del gen SHP-2 en melanomas
CA2528222A1 (en) * 2005-10-31 2007-04-30 Centre For Addiction And Mental Health Slc1a1 marker for anxiety disorder
JP2009514549A (ja) * 2005-11-07 2009-04-09 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド Ｃｈｌａｍｙｄｉａｔｒａｃｈｏｍａｔｉｓ特異的オリゴヌクレオチド配列
AU2006315562C1 (en) 2005-11-12 2013-10-03 The Board Of Trustees Of The Leland Stanford Junior University Methods for treating depression using NCAM peptide mimetics
WO2007120208A2 (en) * 2005-11-14 2007-10-25 President And Fellows Of Harvard College Nanogrid rolling circle dna sequencing
ES2332139T3 (es) 2005-11-23 2010-01-27 F. Hoffmann-La Roche Ag Polinucleotidos con mimetico de fosfato.
CN103710430B (zh) 2005-11-29 2016-03-30 剑桥企业有限公司 乳腺癌标志物
EP1798650A1 (de) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytisches Verfahren und Instrument
EP1798542A1 (de) 2005-12-19 2007-06-20 Roche Diagnostics GmbH Analytisches Verfahren und Gerät
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
KR100652903B1 (ko) * 2005-12-21 2006-12-04 한국과학기술연구원 초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
ES2538038T3 (es) 2006-01-17 2015-06-16 Somalogic, Inc. Análisis multiplexado de muestras de ensayo
EP2069530A2 (de) * 2006-02-06 2009-06-17 Aarhus Universitet Qtls für eutergesundheitsmerkmale bei rindern
WO2007092538A2 (en) 2006-02-07 2007-08-16 President And Fellows Of Harvard College Methods for making nucleotide probes for sequencing and synthesis
US20090181386A1 (en) * 2006-02-08 2009-07-16 Kvaegavlsforeningen Dansire Calving Characteristics
WO2007096182A1 (en) * 2006-02-27 2007-08-30 Roche Diagnostics Gmbh Pcr hot start by magnesium sequestration
CA2644475A1 (en) * 2006-03-01 2007-09-07 Perlegen Sciences, Inc. Markers for addiction
ATE553220T1 (de) 2006-03-13 2012-04-15 Wako Pure Chem Ind Ltd Verfahren zur erkennung eines mutierten gens
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
EP2005175B1 (de) * 2006-04-07 2011-07-27 Hitachi Chemical Company, Ltd. ERHÖHTE EXPRESSION VON T-ZELLENREZEPTORVERMITTELTER TUMORNEKROSEFAKTORSUPERFAMILIE UND CHEMOKIN-MRNA IN PERIPHEREN BLUT LEUKOZYTEN BEI PATIENTEN MIT MORBUS& xA;CROHN
JP2009536021A (ja) * 2006-04-07 2009-10-08 日立化成工業株式会社 関節リウマチの患者の末梢血白血球におけるＦＣ受容体媒介性腫瘍壊死因子スーパーファミリ及びケモカインのｍＲＮＡ発現の増大
US20070264694A1 (en) * 2006-04-07 2007-11-15 Eragen Biosciences, Inc. Use of non-standard bases and proximity effects for gene assembly and conversion of non-standard bases to standard bases during dna synthesis
CA2638782C (en) 2006-04-07 2020-08-25 Siemens Healthcare Diagnostics Inc. Neisseria gonorrhoeae pivng gene specific oligonucleotide sequences
WO2007123553A1 (en) * 2006-04-24 2007-11-01 Xiyu Jia Methods for detection of methylated dna
US9121056B2 (en) * 2006-04-28 2015-09-01 Igor Kutyavin Use of products of PCR amplification carrying elements of secondary structure to improve PCR-based nucleic acid detection
AU2007244658B2 (en) 2006-04-28 2014-02-13 Igor Kutyavin Use of base-modified deoxynucleoside triphosphates
US7989204B2 (en) 2006-04-28 2011-08-02 Viacyte, Inc. Hepatocyte lineage cells
CN101479391A (zh) * 2006-04-28 2009-07-08 比奥根艾迪克Ma公司 用于检测cripto-3的组合物及方法
US8900828B2 (en) * 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
CN101432426B (zh) 2006-05-02 2012-09-19 和光纯药工业株式会社 胞内分枝杆菌检测用引物和探针、以及使用该引物和探针的胞内分枝杆菌的检测方法
US20090298071A1 (en) * 2006-05-08 2009-12-03 Masato Mitsuhashi Method for testing drug sensitivity in solid tumors by quantifying mrna expression in thinly-sliced tumor tissue
US20070264638A1 (en) * 2006-05-10 2007-11-15 Sigma-Aldrich Co. Identification of ginseng and its imposters using genetic variations
US20070264639A1 (en) * 2006-05-10 2007-11-15 Sigma Aldrich, Co. Identification of Echinacea and its imposters using genetic variations
JP2009537152A (ja) 2006-05-17 2009-10-29 カリフォルニア インスティテュート オブ テクノロジー 温度サイクルシステム
US8232091B2 (en) * 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
CN101443009A (zh) 2006-05-18 2009-05-27 卫材R&D管理有限公司 针对甲状腺癌的抗肿瘤剂
US7674924B2 (en) * 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
CA2653321A1 (en) 2006-05-26 2007-12-06 Althea Technologies, Inc. Biochemical analysis of partitioned cells
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
EP1945821B1 (de) 2006-06-06 2011-01-19 Gen-Probe Incorporated Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US8119352B2 (en) * 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
EP1886727A1 (de) 2006-07-14 2008-02-13 Roche Diagnostics GmbH Vorrichtung zur Analyse
US7915014B2 (en) 2006-07-17 2011-03-29 Brandeis University Specialized oligonucleotides and their use in nucleic acid amplification and detection
US7772390B1 (en) 2006-07-18 2010-08-10 The Regents Of The University Of California Lipid mediated nucleic acid synthesis
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US20080213824A1 (en) * 2006-08-04 2008-09-04 Ikonisys, Inc. Synthesis of Labeled Probes
WO2008021431A2 (en) * 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
WO2008021446A2 (en) * 2006-08-15 2008-02-21 Genetag Technology, Inc. Probe-antiprobe compositions and methods for dna or rna detection
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
WO2008026748A1 (fr) 2006-08-28 2008-03-06 Eisai R & D Management Co., Ltd. Agent antitumoral pour cancer gastrique non différencié
EP1900824A1 (de) * 2006-09-14 2008-03-19 Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts Genexpressionsprofile zur Prognose, Diagnose und Therapie von Prostatakrebs und deren Verwendung
WO2008063758A2 (en) 2006-10-05 2008-05-29 Massachussetts Institute Of Technology Multifunctional encoded particles for high-throughput analysis
EP1914303A1 (de) * 2006-10-09 2008-04-23 Qiagen GmbH Thermus eggertssonii DNA Polymerasen
EP2431483B1 (de) 2006-10-20 2015-04-01 Celera Corporation Mit venöser Thrombose assoziierte genetische Polymorphismen, Nachweisverfahren und deren Verwendungen
GB0621864D0 (en) 2006-11-02 2006-12-13 Univ Manchester Assay for fungal infection
US8148067B2 (en) * 2006-11-09 2012-04-03 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US20080131880A1 (en) * 2006-11-22 2008-06-05 Bortolin Laura T PNA-DNA oligomers and methods of use thereof
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US8133701B2 (en) * 2006-12-05 2012-03-13 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
CN101200716B (zh) * 2006-12-11 2012-08-29 霍夫曼-拉罗奇有限公司 使用聚多卡醇和衍生物的核酸分离
EP1932913B1 (de) 2006-12-11 2013-01-16 Roche Diagnostics GmbH Nukleinsäureisolation mithilfe von Polidocanol und Derivaten davon
WO2008076375A2 (en) * 2006-12-13 2008-06-26 Autogenomics, Inc. Concurrent analysis of multiple patient samples using solid phase addressable multiplex test with high signal-to-noise ratio
CN102851369B (zh) 2006-12-13 2015-01-21 卢米耐克斯公司 用于实时pcr多重分析的系统和方法
ATE522608T1 (de) 2006-12-18 2011-09-15 Wako Pure Chem Ind Ltd Primer und sonde zum nachweis von mycobacterium avium sowie verfahren zum nachweis von mycobacterium avium unter verwendung des primers bzw. der sonde
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
EP2118311B1 (de) 2006-12-19 2013-07-03 GeneOhm Sciences, Inc. Nachweis von staphylococcus aureus und identifizierung methicillinresistenter staphylococcus aureus
JP2010514692A (ja) 2006-12-20 2010-05-06 バイエル ヘルスケア リミティド ライアビリティ カンパニー 癌の治療に有用なヒドロキシメチルフェニルピラゾリル尿素化合物
EP2118310B1 (de) * 2006-12-29 2013-03-06 Applied Biosystems, LLC Systeme und verfahren zum nachweis von nukleinsäuren
EP2069525A1 (de) * 2006-12-29 2009-06-17 Applied Biosystems, LLC Systeme und verfahren für den nachweis von nukleinsäuren
AU2008205457A1 (en) * 2007-01-18 2008-07-24 University Of Southern California Gene polymorphisms predictive for dual TKI therapy
CN101711257A (zh) 2007-01-22 2010-05-19 瓦弗根公司 用于高通量化学反应的装置
AU2008211952B2 (en) 2007-01-29 2012-07-19 Eisai R & D Management Co., Ltd. Composition for treatment of undifferentiated-type of gastric cancer
EP2129789B1 (de) 2007-01-31 2013-03-06 Celera Corporation Verfahren zur Prognose von Brustkrebsmetastasen durch eine molekulare Prognosesignatur.
NZ589179A (en) 2007-02-02 2011-01-28 Genera Biosystems Ltd Generation of nucleic acid molecules using solid phase amplification
AU2008213634B2 (en) * 2007-02-08 2013-09-05 Sequenom, Inc. Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification
US20100021917A1 (en) * 2007-02-14 2010-01-28 Cedars-Sinai Medical Center Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease
US20100190162A1 (en) * 2007-02-26 2010-07-29 Cedars-Sinai Medical Center Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
GB0703996D0 (en) * 2007-03-01 2007-04-11 Oxitec Ltd Nucleic acid detection
GB0703997D0 (en) * 2007-03-01 2007-04-11 Oxitec Ltd Methods for detecting nucleic sequences
DE102007013099A1 (de) 2007-03-14 2008-09-18 Aj Innuscreen Gmbh Verfahren und Testkit zum schnellen Nachweis spezifischer Nukleinsäuresequenzen, insbesondere zum Nachweis von Mutationen oder SNP's
US8486640B2 (en) 2007-03-21 2013-07-16 Cedars-Sinai Medical Center Ileal pouch-anal anastomosis (IPAA) factors in the treatment of inflammatory bowel disease
EP2140031A4 (de) 2007-03-26 2011-04-20 Sequenom Inc Restriktionsendonukleaseverstärkte polymorphe sequenzerfassung
DK2574681T3 (en) 2007-03-28 2016-07-04 Signal Diagnostics System and method for high-resolution analysis of nucleic acids to detect sequence variations
JP5191041B2 (ja) 2007-04-05 2013-04-24 エフ．ホフマン−ラ ロシュ アーゲー 急速ワンステップｒｔ−ｐｃｒ
EP2385119B1 (de) 2007-04-06 2015-11-11 Janssen Diagnostics BVBA Test für den Nachweis von Respiratory Syncytial Virus (RSV)-Viruslast
US9290803B2 (en) * 2007-04-12 2016-03-22 University Of Southern California DNA methylation analysis by digital bisulfite genomic sequencing and digital methylight
WO2008127921A2 (en) 2007-04-13 2008-10-23 Abbott Laboratories Primer and probe sequences for detecting chlamydia trachomatis
CA2684570A1 (en) 2007-04-19 2008-10-30 Molecular Detection Inc. Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria
WO2008134569A2 (en) * 2007-04-26 2008-11-06 Cedars-Sinai Medical Center Diagnosis and treatment of inflammatory bowel disease in the puerto rican population
ATE524566T1 (de) * 2007-05-04 2011-09-15 Myconostica Ltd Nachweis von triazolresistenz bei aspergillus
US20100144903A1 (en) * 2007-05-04 2010-06-10 Cedars-Sinai Medical Center Methods of diagnosis and treatment of crohn's disease
BRPI0811271A2 (pt) * 2007-05-31 2015-01-20 Monsanto Technology Llc Polimorfismos da soja e processos de genotipagem
AU2008260029B2 (en) 2007-05-31 2015-02-12 Yale University A genetic lesion associated with cancer
JP5719591B2 (ja) 2007-06-08 2015-05-20 バイオジェン アイデック エムエー インコーポレイティドＢｉｏｇｅｎ Ｉｄｅｃ Ｉｎｃ． 抗ｔｎｆ応答性または非応答性を予測するためのバイオマーカー
WO2008157696A2 (en) 2007-06-19 2008-12-24 Stratos Genomics Inc. High throughput nucleic acid sequencing by expansion
JP5282088B2 (ja) 2007-06-21 2013-09-04 ジェン−プロウブ インコーポレイテッド 処理実行に使用する機器および容器
DE102007029772B4 (de) 2007-06-22 2011-12-08 Aj Innuscreen Gmbh Verfahren und Schnelltest zum Nachweis spezifischer Nukleinsäuresequenzen
WO2009031054A2 (en) 2007-06-29 2009-03-12 Population Genetics Technologies Ltd. Methods and compositions for isolating nucleic acid sequence variants
US9689031B2 (en) 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
EP2489743B1 (de) 2007-07-17 2015-01-07 Somalogic, Inc. Aptamere mit 5-(N-Naphthyl)-substituiertem Uridin
US20090023138A1 (en) * 2007-07-17 2009-01-22 Zila Biotechnology, Inc. Oral cancer markers and their detection
US20090181366A1 (en) * 2007-07-30 2009-07-16 Quest Diagnostics Investments Incorporated Internal positive control for nucleic acid assays
CA2694832A1 (en) 2007-08-06 2009-02-12 Orion Genomics Llc Novel single nucleotide polymorphisms and combinations of novel and known polymorphisms for determining the allele-specific expression of the igf2 gene
JP2010537637A (ja) 2007-08-27 2010-12-09 アプライド バイオシステムズ インコーポレイテッド Ｐｃｒのための方法および組成物
AR071243A1 (es) 2007-08-29 2010-06-09 Monsanto Technology Llc Metodos y composiciones para usar plantas haploides en el mapeo genetico de caracteristicas, como resistencia a enfermedades
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
DE102007041864B4 (de) 2007-09-04 2012-05-03 Sirs-Lab Gmbh Verfahren zum Nachweis von Bakterien und Pilzen
AU2008295992B2 (en) 2007-09-07 2014-04-17 Fluidigm Corporation Copy number variation determination, methods and systems
CA2639416C (en) 2007-09-11 2019-12-31 F. Hoffmann-La Roche Ag Diagnostic test for susceptibility to b-raf kinase inhibitors
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
GB2453173A (en) 2007-09-28 2009-04-01 Dxs Ltd Polynucleotide primers
EP2217719B1 (de) * 2007-10-22 2011-07-13 LGC Limited Oligonukleotide und deren verwendungen
WO2009059022A1 (en) 2007-10-30 2009-05-07 Complete Genomics, Inc. Apparatus for high throughput sequencing of nucleic acids
WO2009059319A1 (en) 2007-11-01 2009-05-07 University Of Iowa Research Foundation Assessing susceptibility to vascular disorders
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
WO2009061640A2 (en) * 2007-11-06 2009-05-14 Siemens Healthcare Diagnostics Inc. Hepatitis b virus (hbv) specific oligonucleotide sequences
US9211537B2 (en) * 2007-11-07 2015-12-15 The University Of British Columbia Microfluidic device and method of using same
EP2218712B1 (de) 2007-11-09 2015-07-01 Eisai R&D Management Co., Ltd. Kombination einer antiangiogenen substanz und eines platinkomplexes mit antitumorwirkung
JP5659018B2 (ja) 2007-11-16 2015-01-28 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ 濾過可能な液体中の酵母およびカビの検出および／または分析方法
PL2220492T3 (pl) 2007-11-30 2012-01-31 Genentech Inc Polimorfizmy VEGF oraz terapia antyangiogenna
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
US20090197254A1 (en) * 2007-12-14 2009-08-06 Ming-Chou Lee Variant scorpion primers for nucleic acid amplification and detection
WO2009085221A2 (en) 2007-12-21 2009-07-09 Biomerieux Sa Detection of methicillin-resistant staphylococcus aureus
US20090186344A1 (en) * 2008-01-23 2009-07-23 Caliper Life Sciences, Inc. Devices and methods for detecting and quantitating nucleic acids using size separation of amplicons
JPWO2009099037A1 (ja) 2008-02-08 2011-05-26 和光純薬工業株式会社 クラミドフィラ・キャビエ検出用プライマー及びプローブ、並びにこれを用いたクラミドフィラ・キャビエの検出方法
WO2009103003A2 (en) * 2008-02-15 2009-08-20 Bio-Rad Laboratories, Inc. Scanning fluorescent reader with diffuser system
CN102066580A (zh) * 2008-02-20 2011-05-18 岩城公輔 多瘤病毒的检测
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
US20090215064A1 (en) * 2008-02-27 2009-08-27 Hitachi Chemical Co., Ltd. Quantitative assessment of individual cancer susceptibility by measuring dna damage-induced mrna in whole blood
US8709726B2 (en) * 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
WO2009117327A2 (en) * 2008-03-15 2009-09-24 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules during amplification reactions
CA2658520C (en) 2008-03-19 2016-11-08 F. Hoffmann-La Roche Ag Nucleic acid amplification in the presence of modified randomers
WO2009120808A2 (en) 2008-03-26 2009-10-01 Sequenom, Inc. Restriction endonuclease enhanced polymorphic sequence detection
EP2108699B1 (de) 2008-04-08 2014-06-25 F.Hoffmann-La Roche Ag Vorrichtung zur analytischen Verarbeitung und Detektion
US8206925B2 (en) * 2008-04-14 2012-06-26 Medical Diagnostic Laboratories, Llc Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases
US9249455B2 (en) * 2008-04-18 2016-02-02 Luminex Corporation Methods for detection and quantification of small RNA
BRPI0911551B8 (pt) 2008-04-24 2023-10-03 Monsanto Technology Llc Método para produzir planta de soja resistente a ferrugem asiática da soja (asr)
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
EP2644709B1 (de) 2008-04-30 2014-12-17 Integrated Dna Technologies, Inc. Rnase-h-basierte assays unter verwendung von modifizierten rna monomeren
CA2723726C (en) 2008-05-13 2017-09-12 Michael M. Becker Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
EP2123360A1 (de) 2008-05-20 2009-11-25 F.Hoffmann-La Roche Ag Thermozyklierungsvorrichtung mit Thermozyklermodul mit Wärmeschutzschalter, Verfahren zur Kühlung eines Heizblocks in einem Thermozyklermodul einer Thermozyklierungsvorrichtung und Analysegerät
EP2284262A4 (de) 2008-05-28 2012-02-22 Wako Pure Chem Ind Ltd Primer und sonde für den nachweis von mycobacterium intracellulare und verfahren für den nachweis von mycobacterium intracellulare mit dem primer oder der sonde
US8208909B2 (en) 2008-06-02 2012-06-26 West Corporation System, apparatus and method for availing a mobile call of address information
EP2133434A1 (de) 2008-06-12 2009-12-16 Institut National de la Santé et de la Recherche Médicale (INSERM) Verfahren zum Nachweis von Zielnukleinsäuren
EP2235177B1 (de) * 2008-06-13 2012-07-18 RiboxX GmbH Verfahren zur enzymatischen synthese chemisch modifizierter rna
IES20090467A2 (en) * 2008-06-13 2010-03-31 Nat Univ Ireland Ace2 as a target gene for the molecular identification of yeast and fungal species.
EP2141246A1 (de) 2008-07-01 2010-01-06 Koninklijke Philips Electronics N.V. Spaltungslose Verfahren zur PCR-Erkennung mithilfe von SERRS
US8216786B2 (en) 2008-07-09 2012-07-10 Celera Corporation Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
EP2147981A1 (de) 2008-07-25 2010-01-27 Biotype AG Kit und Verfahren zur Auswertung der Detektionseigenschaften bei Verstärkungsreaktionen
CA2638458A1 (en) * 2008-07-31 2010-01-31 Spartan Bioscience Inc. Thermal recycling by positioning relative to fixed-temperature source
GB0909333D0 (en) 2009-06-01 2009-07-15 Fu Guoliang Multiplex amplification and detection
ES2539856T3 (es) 2008-08-01 2015-07-06 F. Hoffmann-La Roche Ag Lisis mejorada y transcripción reversa para la cuantificación de mRNA
EP2329039B1 (de) * 2008-09-03 2016-05-11 Quantumdx Group Limited Wahrnehmungsstrategien und verfahren zum nukleinsäurenachweis mit biosensoren
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
US9250249B2 (en) 2008-09-08 2016-02-02 Enzo Biochem, Inc. Autophagy and phospholipidosis pathway assays
US7910720B2 (en) 2008-09-09 2011-03-22 Roche Diagnostics Operations, Inc. Polyanion for improved nucleic acid amplification
WO2010030716A1 (en) * 2008-09-10 2010-03-18 Igor Kutyavin Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9090948B2 (en) 2008-09-30 2015-07-28 Abbott Molecular Inc. Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
US20110177969A1 (en) * 2008-10-01 2011-07-21 Cedars-Sinai Medical Center The role of il17rd and the il23-1l17 pathway in crohn's disease
CA2682439A1 (en) 2008-10-17 2010-04-17 F. Hoffmann-La Roche Ag Cell monitoring and molecular analysis
CA2740913C (en) 2008-10-20 2015-02-10 F. Hoffmann-La Roche Ag Improved allele-specific amplification
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
CA2779197C (en) 2008-10-27 2021-06-29 Infraegis, Inc. Method of removing polymerase chain reaction (pcr) inhibitors from a sample using .beta.-cyclodextrin and activated charcoal coated with bentonite
KR101719376B1 (ko) 2008-11-05 2017-03-23 제넨테크, 인크. 연령-관련 황반 변성에서 유전자 다형성
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US8236503B2 (en) 2008-11-07 2012-08-07 Sequenta, Inc. Methods of monitoring conditions by sequence analysis
US9394567B2 (en) 2008-11-07 2016-07-19 Adaptive Biotechnologies Corporation Detection and quantification of sample contamination in immune repertoire analysis
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
EP2352846B1 (de) 2008-11-13 2015-01-07 Riboxx GmbH Rna-nachweisverfahren
US10669574B2 (en) 2008-11-18 2020-06-02 XCR Diagnostics, Inc. DNA amplification technology
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
EP2373808B1 (de) 2008-12-09 2015-11-25 Oxitec Limited Verbesserte amplifikation auf taqman-sondenbasis
CA2688174C (en) 2008-12-19 2018-08-07 F. Hoffmann-La Roche Ag Dry composition of reaction compounds with stabilized polymerase
US8211637B2 (en) 2008-12-19 2012-07-03 Life Technologies Corporation Proteinase K inhibitors, methods and compositions therefor
WO2010075579A2 (en) 2008-12-24 2010-07-01 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
IT1397110B1 (it) * 2008-12-29 2012-12-28 St Microelectronics Rousset Microreattore autosigillante e metodo per eseguire una reazione
US8206929B2 (en) 2009-01-07 2012-06-26 Roche Molecular Systems, Inc. Nucleic acid amplification with allele-specific suppression of sequence variants
SG172965A1 (en) 2009-01-13 2011-08-29 Fluidigm Corp Single-cell nucleic acid analysis
ES2726702T3 (es) 2009-01-15 2019-10-08 Adaptive Biotechnologies Corp Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales
US20100285473A1 (en) 2009-01-27 2010-11-11 John Wolff Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
US20120028254A1 (en) 2009-02-06 2012-02-02 Weidhaas Joanne B SNP Marker of Breast and Ovarian Cancer Risk
ES2544265T3 (es) 2009-02-11 2015-08-28 Orion Genomics, Llc Combinaciones de polimorfismos para determinar la expresión específica de alelo de IGF2
US9347092B2 (en) * 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
JP5457222B2 (ja) * 2009-02-25 2014-04-02 エフ．ホフマン−ラ ロシュ アーゲー 小型化ハイスループット核酸分析
US8039215B2 (en) 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
US9034605B2 (en) 2009-03-12 2015-05-19 Brandeis University Reagents and methods for PCR
EP2408936A4 (de) * 2009-03-18 2013-01-30 Sequenom Inc Verwendung wärmestabiler endonukleasen zur herstellung von reportermolekülen
WO2010112033A2 (en) 2009-03-31 2010-10-07 Østjysk Innovation A/S Method for estimating the risk of having or developing multiple sclerosis using sequence polymorphisms in a specific region of chromosome x
CN102439177B (zh) 2009-04-02 2014-10-01 弗卢伊蒂格姆公司 用于对目标核酸进行条形码化的多引物扩增方法
CN202830041U (zh) 2009-04-03 2013-03-27 Illumina公司 用于加热生物样本的设备
WO2010116290A1 (en) 2009-04-07 2010-10-14 Koninklijke Philips Electronics N.V. Method for the detection and characterization of a toxinogenic clostridium difficile strain
NZ596528A (en) 2009-04-22 2014-04-30 Vertex Pharma Probe set for identification of nucleotide mutation, and method for identification of nucleotide mutation
WO2010123626A1 (en) 2009-04-24 2010-10-28 University Of Southern California Cd133 polymorphisms and expression predict clinical outcome in patients with cancer
CA2760439A1 (en) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Methods and compositions for evaluating genetic markers
EP2256215A1 (de) 2009-04-30 2010-12-01 Steffen Mergemeier Testsystem unter Verwendung einer Nukleaseaktivität einer Nukleinsäurepolymerase
EP2248915B1 (de) * 2009-05-05 2013-09-18 Qiagen GmbH Detektion mehrerer Nukleinsäuresequenzen in einer Reaktionskartusche
US20100299773A1 (en) * 2009-05-20 2010-11-25 Monsanto Technology Llc Methods and compositions for selecting an improved plant
WO2010133972A1 (en) 2009-05-22 2010-11-25 Population Genetics Technologies Ltd Sorting asymmetrically tagged nucleic acids by selective primer extension
EP2267153A1 (de) 2009-05-26 2010-12-29 Université Claude Bernard Lyon 1 Identifizierung der Netrin-1-Rezeptor-unc5c-Genmutation bei festen Krebsen
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
WO2010138187A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Scaffolded nucleic acid polymer particles and methods of making and using
US20110237537A1 (en) * 2009-05-29 2011-09-29 Lombard Jay L Methods for assessment and treatment of mood disorders via single nucleotide polymorphisms analysis
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US20100304391A1 (en) * 2009-05-29 2010-12-02 Lombard Jay L Methods for assessment and treatment of depression via utilization of single nucleotide polymorphisms analysis
US8355927B2 (en) 2010-11-05 2013-01-15 Genomind, Llc Neuropsychiatric test reports
JP2012531210A (ja) 2009-06-25 2012-12-10 イェール ユニバ−シティ− Ｂｒｃａ１における一塩基多型および癌のリスク
CN102459643B (zh) 2009-06-25 2016-06-01 弗雷德哈钦森癌症研究中心 检测获得性免疫的方法
IL206810A (en) * 2009-07-08 2015-07-30 Janssen Diagnostics Llc Methods for identifying melanoma and kits for using these methods
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
CN102596188A (zh) 2009-07-14 2012-07-18 贝思以色列女教会医学中心 增加肝脏增殖的方法
WO2011011391A1 (en) 2009-07-22 2011-01-27 E.I. Dupont De Nemours And Company Sequences and their use for detection and characterization of e. coli o157:h7
EP2464754B1 (de) 2009-08-13 2014-03-12 Life Technologies Corporation Amelogenin-snp auf x-chromosomen
WO2011021102A2 (en) 2009-08-20 2011-02-24 Population Genetics Technologies Ltd Compositions and methods for intramolecular nucleic acid rearrangement
US8697435B2 (en) * 2009-08-31 2014-04-15 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
DE202010010523U1 (de) 2009-09-09 2010-11-18 Helixis, Inc., Carlsbad Optisches System für Mehrfachreaktionen
WO2011030091A1 (en) 2009-09-11 2011-03-17 Myconostica Limited Assay for candida species
JP2013505718A (ja) * 2009-09-24 2013-02-21 シージーン アイエヌシー 反復的エキソ核酸切断反応によるターゲット核酸配列の検出
WO2011037802A2 (en) 2009-09-28 2011-03-31 Igor Kutyavin Methods and compositions for detection of nucleic acids based on stabilized oligonucleotide probe complexes
RU2577726C2 (ru) 2009-10-21 2016-03-20 Дженентек, Инк. Генетические полиморфизмы при возрастной дегенерации желтого пятна
JP5938348B2 (ja) * 2009-10-23 2016-06-22 ルミネックス コーポレーション 反応特異性の増加のための非標準塩基を含む増幅プライマー
US9315860B2 (en) 2009-10-26 2016-04-19 Genovoxx Gmbh Conjugates of nucleotides and method for the application thereof
JP6147502B2 (ja) 2009-10-27 2017-06-14 スウィフト バイオサイエンシーズ， インコーポレイテッド ポリヌクレオチドプライマー及びプローブ
US8927215B2 (en) 2009-10-30 2015-01-06 The Regents Of The University Of California GNA11 mutations in melanoma
EP2494353B1 (de) 2009-10-30 2017-09-27 Illumina Inc. Vorrichtung mit einer Mehrzahl von codierten Mikrogefäßen und einer Vielzahl von Fächern und ein Verfahren zum Lesen einer Mehrzahl von codierten Mikrogefäßen
WO2011055232A2 (en) 2009-11-04 2011-05-12 Population Genetics Technologies Ltd. Base-by-base mutation screening
KR20110050327A (ko) 2009-11-07 2011-05-13 주식회사 씨젠 Ｔｈｄ 프라이머 타겟 검출
RU2012124051A (ru) 2009-11-13 2013-12-20 Бекман Каултер, Инк. Системы и способы для обнаружения наличия биологического признака с применением кластеризации
JP5907879B2 (ja) 2009-11-13 2016-04-26 ベックマン コールター， インコーポレイテッド プロットを用いて生物学的持続状態の存在を検出するためのシステムおよび方法
US20110117546A1 (en) * 2009-11-18 2011-05-19 Microfluidic Systems, Inc. Increase of signal sensitivity using dual probes in pcr reactions
EP2507393A4 (de) 2009-11-30 2013-05-01 Caris Life Sciences Luxembourg Holdings Verfahren und systeme zur isolation, speicherung und analyse von vesikeln
US9133343B2 (en) 2009-11-30 2015-09-15 Enzo Biochem, Inc. Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
US9200331B2 (en) 2009-12-03 2015-12-01 Quest Diagnostics Investments Incorporated Methods for the diagnosis of bacterial vaginosis
US9238832B2 (en) 2009-12-11 2016-01-19 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids
US8614071B2 (en) 2009-12-11 2013-12-24 Roche Molecular Systems, Inc. Preferential amplification of mRNA over DNA using chemically modified primers
AU2010336137B2 (en) 2009-12-21 2015-08-06 Seegene, Inc. TSG primer target detection
WO2011084757A1 (en) 2009-12-21 2011-07-14 University Of Southern California Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer
EP2516680B1 (de) 2009-12-22 2016-04-06 Sequenom, Inc. Verfahren und kits zur identifizierung von aneuploidie
US8877437B1 (en) 2009-12-23 2014-11-04 Biotium, Inc. Methods of using dyes in association with nucleic acid staining or detection
WO2011085334A1 (en) 2010-01-11 2011-07-14 University Of Southern California Cd44 polymorphisms predict clinical outcome in patients with gastric cancer
AU2011205230A1 (en) 2010-01-13 2012-08-02 Caris Life Sciences Switzerland Holdings Gmbh Detection of gastrointestinal disorders
EP2534263B1 (de) * 2010-02-09 2020-08-05 Unitaq Bio Verfahren und zusammensetzungen zur universellen erkennung von nukleinsäuren
WO2011101744A2 (en) 2010-02-22 2011-08-25 Population Genetics Technologies Ltd. Region of interest extraction and normalization methods
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
WO2011107887A2 (en) 2010-03-02 2011-09-09 Population Genetic Technologies Ltd. Methods for replicating polynucleotides with secondary structure
US9458513B2 (en) 2010-03-23 2016-10-04 Wako Pure Chemical Industries, Ltd. Primer and probe for detecting chlamydia trachomatis, and method for detecting chlamydia trachomatis using same
AU2011230496B2 (en) 2010-03-26 2015-09-17 Integrated Dna Technologies, Inc. Methods for enhancing nucleic acid hybridization
US20120108799A1 (en) 2010-09-07 2012-05-03 Integrated Dna Technologies, Inc. Modifications for Antisense Compounds
US9506057B2 (en) 2010-03-26 2016-11-29 Integrated Dna Technologies, Inc. Modifications for antisense compounds
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
DE102010003781B4 (de) 2010-04-08 2012-08-16 Aj Innuscreen Gmbh Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen
US20110250598A1 (en) 2010-04-12 2011-10-13 Ulrike Fischer Detergent free polymerases
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
WO2011130728A1 (en) 2010-04-17 2011-10-20 Bayer Healthcare Llc Synthetic metabolites of fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention diseases and conditions
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
JP6058529B2 (ja) 2010-04-21 2017-01-11 エリック ベルントルプ， 血友病ａにおけるインヒビターの発達と関連する遺伝因子
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
JP6085249B2 (ja) 2010-05-06 2017-02-22 アダプティヴ バイオテクノロジーズ コーポレーション 複雑なアンプリコンの配列解析
US9309565B2 (en) 2010-05-14 2016-04-12 Life Technologies Corporation Karyotyping assay
US8618253B2 (en) 2010-05-25 2013-12-31 Samsung Techwin Co., Ltd. Modified RNAse H and detection of nucleic acid amplification
US8628914B2 (en) * 2010-05-26 2014-01-14 Qiagen Gaithersburg, Inc. Quantitative helicase assay
US8828688B2 (en) 2010-05-27 2014-09-09 Affymetrix, Inc. Multiplex amplification methods
EP2576577B1 (de) 2010-05-28 2015-03-18 Life Technologies Corporation Synthese von 2', 3'-dideoxynucleosiden für automatisierte dna-synthese und pyrophosphorolyse-aktivierte polymerisation
WO2011156434A2 (en) 2010-06-07 2011-12-15 Firefly Bioworks, Inc. Nucleic acid detection and quantification by post-hybridization labeling and universal encoding
JP2013529089A (ja) 2010-06-07 2013-07-18 エフ．ホフマン−ラ ロシュ アーゲー インターロイキン−６受容体を阻害するモノクローナル抗体による薬剤治療に対する応答を予測するための遺伝子発現マーカー
WO2011156707A2 (en) 2010-06-11 2011-12-15 Life Technologies Corporation Alternative nucleotide flows in sequencing-by-synthesis methods
CN103025869B (zh) 2010-06-18 2015-07-01 霍夫曼-拉罗奇有限公司 具有增强的3’-错配辨别力的dna聚合酶
CA2802304C (en) 2010-06-18 2016-01-12 F.Hoffman-La Roche Ag Dna polymerases with increased 3'-mismatch discrimination
WO2011157432A1 (en) 2010-06-18 2011-12-22 Roche Diagnostics Gmbh Dna polymerases with increased 3'-mismatch discrimination
EP2582802B1 (de) 2010-06-18 2016-01-13 Roche Diagnostics GmbH Dna-polymerasen mit erhöhter unterscheidung von 3'-diskrepanz
JP5841136B2 (ja) 2010-06-18 2016-01-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
JP5876479B2 (ja) 2010-06-18 2016-03-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別を有するｄｎａポリメラーゼ
JP5876478B2 (ja) 2010-06-18 2016-03-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
JP5926246B2 (ja) 2010-06-18 2016-05-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
EP2585593B1 (de) 2010-06-24 2017-03-01 Population Genetics Technologies Ltd. Verfahren zur herstellung und verewigung einer polynukleotid-bibliothek sowie zur extraktion relevanter bereiche daraus
ES2573515T3 (es) 2010-06-25 2016-06-08 Eisai R&D Management Co., Ltd. Agente antitumoral que emplea compuestos con efecto inhibitorio de cinasas combinados
WO2012003409A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Detection of listeria species in food and environmental samples, methods and compositions thereof
US20120009575A1 (en) 2010-06-30 2012-01-12 Life Technologies Corporation Inducible nucleic acid targets for detection of pathogens, methods and compositions thereof
US9650629B2 (en) 2010-07-07 2017-05-16 Roche Molecular Systems, Inc. Clonal pre-amplification in emulsion
WO2012016936A1 (de) 2010-07-31 2012-02-09 Aj Innuscreen Gmbh Nachweis spezifischer nukleinsäuresequenzen mittels fluoreszenz - quenching
DE102010033107A1 (de) 2010-08-02 2012-02-02 Aj Innuscreen Gmbh Nachweis spezifischer Nukleinsäuresequenzen mittels Fluoreszenzlöschung
US9175354B2 (en) 2010-08-03 2015-11-03 Life Technologies Corporation Detection of Salmonella enterica subspecies enterica serovar Enteritidis in food and environmental samples, methods and compositions therefor
CN106198656B (zh) 2010-08-18 2018-12-11 生命科技股份有限公司 用于电化学检测装置的微孔的化学涂层
US8557532B2 (en) 2010-08-30 2013-10-15 The University Of Utah Research Foundation Diagnosis and treatment of drug-resistant Ewing'S sarcoma
EP2611932A2 (de) 2010-08-30 2013-07-10 Gen-Probe Incorporated Zusammensetzungen, verfahren und reaktionsmischungen für den nachweis von xenotropic murine leukemia virus-related virus (xmrv)
JP5917519B2 (ja) 2010-09-10 2016-05-18 バイオ−ラッド ラボラトリーズ インコーポレーティッド クロマチン分析のためのｄｎａのサイズ選択
US9051606B2 (en) 2010-09-10 2015-06-09 Qiagen Gaithersburg, Inc. Methods and compositions for nucleic acid detection
CN103119175B (zh) * 2010-09-20 2017-11-28 Seegene株式会社 在固相利用单一标记固定化探针及外切核酸活性的靶核酸序列检测
CN110878345A (zh) 2010-09-21 2020-03-13 安捷伦科技有限公司 通过分子计数提高等位基因调用的置信度
US9090946B2 (en) 2010-09-21 2015-07-28 Life Technologies Corporation SE33 mutations impacting genotype concordance
WO2012038049A2 (en) 2010-09-22 2012-03-29 Roche Diagnostics Gmbh Amplification of distant nucleic acid targets using engineered primers
KR20130113447A (ko) 2010-09-24 2013-10-15 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
WO2012040619A2 (en) 2010-09-24 2012-03-29 Massachusetts Eye And Ear Infirmary Methods and compositions for prognosing and/or detecting age-related macular degeneration
JP5798631B2 (ja) 2010-10-04 2015-10-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｒｔ−ｐｃｒ反応緩衝液中での細胞溶解のための方法
JP6174999B2 (ja) 2010-10-04 2017-08-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｐｃｒ反応緩衝液中での細胞溶解のための方法
CN103124797B (zh) 2010-10-04 2015-04-22 霍夫曼-拉罗奇有限公司 用于在相同反应容器内的细胞裂解和pcr的方法
US9902950B2 (en) 2010-10-08 2018-02-27 President And Fellows Of Harvard College High-throughput single cell barcoding
EP3561073A1 (de) 2010-10-08 2019-10-30 President and Fellows of Harvard College Immunsequenzierung mit hohem durchsatz
US8725422B2 (en) 2010-10-13 2014-05-13 Complete Genomics, Inc. Methods for estimating genome-wide copy number variations
AR083497A1 (es) * 2010-10-21 2013-02-27 Riken Kit para detectar el virus de la leucemia bovina (blv), y uso del mismo
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012052758A1 (en) 2010-10-22 2012-04-26 Astrazeneca Ab Response biomarkers for iap antagonists in human cancers
KR20120042100A (ko) 2010-10-22 2012-05-03 주식회사 씨젠 이중표지 고정화 프로브를 이용한 고상에서의 타겟 핵산서열 검출
EP2630517B1 (de) 2010-10-22 2016-03-16 T2 Biosystems, Inc. Nmr-systeme und verfahren zum schnellen nachweis von analyten
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
GB201017978D0 (en) 2010-10-25 2010-12-08 Oxitec Ltd Multiplex amplification and detection
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
DE102010052524A1 (de) 2010-11-22 2012-05-24 Aj Innuscreen Gmbh Verfahren zum qualitativen und quantitativen Nachweis von spezifischen Nukleinsäuresequenzen in Echtzeit
US20130324436A1 (en) 2010-11-30 2013-12-05 Diagon Kft Procedure for nucleic acid-based diagnostic determination of bacterial germ counts and kit for this purpose
WO2012075231A1 (en) 2010-12-03 2012-06-07 Brandeis University Methods and kits for detecting nucleic acid mutants in wild-type populations
WO2012087135A1 (en) 2010-12-22 2012-06-28 Academisch Ziekenhuis Leiden H.O.D.N. Lumc Genetic markers specific for clostridium difficile ribotypes 027 (nap01/b1; rt 027) and 078 (nap7/8; rt 078) and their use
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
WO2012092259A1 (en) 2010-12-27 2012-07-05 Ibis Biosciences, Inc. Quantitating high titer samples by digital pcr
US9487838B2 (en) 2010-12-28 2016-11-08 Qiagen Hamburg Gmbh Oligonucleotide probe for the detection of adenovirus
WO2012118555A1 (en) 2010-12-29 2012-09-07 Life Technologies Corporation Time-warped background signal for sequencing-by-synthesis operations
BR112013015595A2 (pt) 2010-12-30 2017-06-20 Pioneer Hi Bred Int método de identificação de uma primeira planta de feijão soja ou germoplasma que exibe resistência aprimorada a um ou mais biotipos de afídeo de feijão soja, polinucleotídeo isolado, kit para detectar ou selecionar pelo menos uma planta de feijão soja com resistência a afídeo aprimorada
US20130060482A1 (en) 2010-12-30 2013-03-07 Life Technologies Corporation Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
US10146906B2 (en) 2010-12-30 2018-12-04 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US10241075B2 (en) 2010-12-30 2019-03-26 Life Technologies Corporation Methods, systems, and computer readable media for nucleic acid sequencing
MX352460B (es) 2011-01-11 2017-11-24 Seegene Inc Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
EP3733870A3 (de) 2011-01-14 2021-01-27 Life Technologies Corporation Verfahren zur identifikation und quantifizierung von mirnas
WO2012099896A2 (en) 2011-01-17 2012-07-26 Life Technologies Corporation Workflow for detection of ligands using nucleic acids
WO2012106288A2 (en) * 2011-01-31 2012-08-09 Primeradx, Inc. Methods of nucleic acid quantification and detection using anomalous migration
WO2012108864A1 (en) 2011-02-08 2012-08-16 Illumina, Inc. Selective enrichment of nucleic acids
EP2673376A1 (de) 2011-02-09 2013-12-18 RiboxX GmbH Verfahren für den nachweis von polynukleotidsequenzen
JP5847201B2 (ja) 2011-02-15 2016-01-20 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
WO2012112606A1 (en) 2011-02-15 2012-08-23 Bio-Rad Laboratories, Inc. Detecting methylati0n in a subpopulation of genomic dna
EP2675914A1 (de) 2011-02-18 2013-12-25 Yale University, Inc. Kras-variante und endometriose
WO2012122571A1 (en) 2011-03-10 2012-09-13 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
WO2012129352A1 (en) 2011-03-21 2012-09-27 Yale University The kras variant and tumor biology
WO2012135053A2 (en) 2011-03-25 2012-10-04 Integrated Dna Technologies, Inc. Rnase h-based assays utilizing modified rna monomers
CN103534358B (zh) 2011-03-29 2015-03-25 Seegene株式会社 基于pto切割以及延伸-依赖性切割的靶核酸序列的检测
EP2508625A1 (de) 2011-04-05 2012-10-10 Université de Franche-Comté Echtzeit-Duplex-PCR für zur simultanen HPV16- und HPV18-Viruslastquantifizierung
US9428807B2 (en) 2011-04-08 2016-08-30 Life Technologies Corporation Phase-protecting reagent flow orderings for use in sequencing-by-synthesis
CA2831180C (en) 2011-04-11 2017-02-14 Keith Bauer Dna polymerases with improved activity
US8962650B2 (en) 2011-04-18 2015-02-24 Eisai R&D Management Co., Ltd. Therapeutic agent for tumor
EP2702171A1 (de) 2011-04-27 2014-03-05 Cherkasov, Dmitry Methoden und komponenten zur detektion von nukleinsäureketten
CN106912197B (zh) 2011-04-28 2022-01-25 生命技术公司 用于多重pcr的方法和组合物
WO2012149193A2 (en) 2011-04-29 2012-11-01 Monsanto Technology Llc Diagnostic molecular markers for seed lot purity traits in soybeans
CN103717750B (zh) 2011-04-29 2017-03-08 塞昆纳姆股份有限公司 少数核酸物质的定量
US9476040B2 (en) 2011-05-02 2016-10-25 Board Of Regents Of The University Of Nebraska Plants with useful traits and related methods
MX342067B (es) * 2011-05-04 2016-09-09 Seegene Inc Detección de secuencias de ácido nucleico objetivo por desdoblamiento e hibridización de oligonucleótido de sonda.
US9850524B2 (en) 2011-05-04 2017-12-26 Seegene, Inc. Detection of target nucleic acid sequences by PO cleavage and hybridization
WO2012153153A1 (en) 2011-05-11 2012-11-15 Diagon Kft. Procedure for rapid determination of viruses using nucleic acid-based molecular diagnostics, and a kit for this purpose
US9034581B2 (en) 2011-05-26 2015-05-19 Roche Molecular Systems, Inc. Compositions and methods for detection of Staphylococcus aureus
JP6038128B2 (ja) 2011-06-03 2016-12-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 レンバチニブ化合物に対する甲状腺癌対象及び腎臓癌対象の反応性を予測及び評価するためのバイオマーカー
DK2718260T3 (en) 2011-06-08 2018-11-19 Life Technologies Corp DESIGN AND DEVELOPMENT OF NEW DETERGENTS FOR USE IN PCR SYSTEMS
US9567628B2 (en) 2011-06-08 2017-02-14 Life Technologies Corporation Polymerization of nucleic acids using proteins having low isoelectric points
US20140186845A1 (en) 2011-06-14 2014-07-03 Universite Paul Sabatier - Toulouse Iii Methods for determining the expression level of a gene of interest including correction of rt-qpcr data for genomic dna-derived signals
US9988668B2 (en) 2011-06-23 2018-06-05 Anitoa Systems, Llc Apparatus for amplification of nucleic acids
US9487824B2 (en) 2011-06-28 2016-11-08 Igor Kutyavin Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences
DE102011078342A1 (de) 2011-06-29 2013-01-03 Aj Innuscreen Gmbh Rehybridisierendes Sondensystem zur qualitativen und quantitativen Messung von spezifischen Nukleinsäuren in Echtzeit
EP2737061B1 (de) 2011-07-28 2015-09-16 Roche Diagnostics GmbH Dna-polymerasen mit verbesserter aktivität
US9758837B2 (en) 2011-08-02 2017-09-12 The United States Of America, As Represented By The Secretary Of Agriculture Sensitive and rapid method for Candidatus Liberibacter species detection
US8778843B1 (en) 2011-08-03 2014-07-15 Fry Laboratories, L.L.C. Semi-pan-protozoal by quantitative PCR
US8592156B2 (en) 2011-08-08 2013-11-26 Roche Molecular Systems, Inc. Predicting response to anti-CD20 therapy in DLBCL patients
EP3624124B1 (de) 2011-08-18 2023-11-22 Life Technologies Corporation Systeme zur herstellung von basenzuordnungen in einer nukleinsäuresequenzierung
SG2014008585A (en) 2011-08-31 2014-04-28 Hoffmann La Roche Method for predicting risk of hypertension associated with anti-angiogenesis therapy
PT3517615T (pt) 2011-08-31 2022-08-09 Seminis Vegetable Seeds Inc Métodos e composições para a firmeza da melancia
US10704164B2 (en) 2011-08-31 2020-07-07 Life Technologies Corporation Methods, systems, computer readable media, and kits for sample identification
EP2751281A1 (de) 2011-08-31 2014-07-09 F.Hoffmann-La Roche Ag Ansprechempfindlichkeit auf angiogenesehemmer
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
CN103946398B (zh) 2011-09-15 2019-08-13 健能泰格技术公司 探针：反义探针组合物对高特异性dna或rna的检测
CA2840242C (en) 2011-09-16 2019-03-26 Gilead Sciences, Inc. Methods for treating hcv
AU2012307282B2 (en) 2011-09-16 2018-03-15 Lexogen Gmbh Nucleic acid transcription method
EP2570487A1 (de) 2011-09-16 2013-03-20 Lexogen GmbH Verfahren zur Nukleinsäuretranskription
BR112014006419A2 (pt) 2011-09-19 2018-08-07 Genentech Inc métodos para tratar um paciente com câncer, kit e artigo
WO2013041577A1 (en) 2011-09-20 2013-03-28 Vib Vzw Methods for the diagnosis of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
WO2013044097A1 (en) 2011-09-21 2013-03-28 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
WO2013041194A1 (en) 2011-09-23 2013-03-28 Roche Diagnostics Gmbh Use of g-clamp for improved allele-specific pcr
AU2012315852B2 (en) 2011-09-28 2018-03-01 Qualicon Diagnostics, Llc Sequences and their use for detection and characterization of STEC bacteria
KR20160100415A (ko) 2011-09-29 2016-08-23 루미넥스 코포레이션 가수분해 프로브
US9416153B2 (en) 2011-10-11 2016-08-16 Enzo Life Sciences, Inc. Fluorescent dyes
EP2766498B1 (de) 2011-10-14 2019-06-19 President and Fellows of Harvard College Sequenzierung durch strukturanordnung
CA2852665A1 (en) 2011-10-17 2013-04-25 Good Start Genetics, Inc. Analysis methods
US9279159B2 (en) 2011-10-21 2016-03-08 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
ES2791830T3 (es) 2011-10-28 2020-11-06 Univ California Mutaciones de FLT3 asociadas a resistencia a fármacos en pacientes con aml que tienen mutaciones activadoras en FLT3
ES2755934T3 (es) 2011-10-31 2020-04-24 Eiken Chemical Método para detectar ácido nucleico diana
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
CN103917665B (zh) 2011-11-09 2016-11-16 纳幕尔杜邦公司 用于沙门氏菌检测的序列和它们的用法
WO2013076029A1 (en) 2011-11-23 2013-05-30 F. Hoffmann-La Roche Ag Responsiveness to angiogenesis inhibitors
CN104053786B (zh) 2011-11-29 2017-06-06 生命技术公司 用于多重pcr的方法和组合物
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
WO2013081864A1 (en) 2011-11-29 2013-06-06 Life Technologies Corporation Methods and compositions for multiplex pcr
US9260714B2 (en) 2011-12-02 2016-02-16 Roche Molecular Systems, Inc. Suppression of non-specific amplification with high-homology oligonucleotides
EP2788480B1 (de) 2011-12-08 2019-01-16 Roche Diagnostics GmbH Dna-polymerasen mit verbesserter aktivität
ES2569723T3 (es) 2011-12-08 2016-05-12 F. Hoffmann-La Roche Ag Polimerasas de DNA con actividad mejorada
EP2788481B1 (de) 2011-12-08 2018-03-07 Roche Diagnostics GmbH Dna-polymerasen mit verbesserter aktivität
EP3904536A1 (de) 2011-12-09 2021-11-03 Adaptive Biotechnologies Corporation Diagnose von lymphoid-malignität und nachweis minimaler resterkrankungen
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US9115394B2 (en) 2011-12-22 2015-08-25 Roche Molecular Systems, Inc. Methods and reagents for reducing non-specific amplification
JP2015511116A (ja) 2011-12-23 2015-04-16 ビオメリューＢｉｏｍｅｒｉｅｕｘ メチシリン耐性黄色ブドウ球菌の変異型ｍｅｃＡ株の検出
WO2013101750A1 (en) 2011-12-29 2013-07-04 Pioneer Hi-Bred International, Inc. Methods of improving aphid resistance in soybeans
EP2872523B1 (de) 2011-12-30 2018-01-17 Abbott Molecular Inc. Mikroorganismus-nukleinsäurereinigung von wirtsproben
US9194840B2 (en) 2012-01-19 2015-11-24 Life Technologies Corporation Sensor arrays and methods for making same
US9864846B2 (en) 2012-01-31 2018-01-09 Life Technologies Corporation Methods and computer program products for compression of sequencing data
US9515676B2 (en) 2012-01-31 2016-12-06 Life Technologies Corporation Methods and computer program products for compression of sequencing data
KR20130101952A (ko) 2012-02-02 2013-09-16 주식회사 씨젠 Ｐｔｏ 절단과 연장-의존적 혼성화를 이용한 타겟 핵산서열의 검출
EP3544015A1 (de) 2012-02-03 2019-09-25 California Institute of Technology Signalcodierung und -decodierung bei biochemischen multiplextests
WO2013123125A1 (en) 2012-02-17 2013-08-22 President And Fellows Of Harvard College Assembly of nucleic acid sequences in emulsions
WO2013124743A1 (en) 2012-02-22 2013-08-29 Population Genetics Technologies Ltd. Compositions and methods for intramolecular nucleic acid rearrangement ii
EP3287531B1 (de) 2012-02-28 2019-06-19 Agilent Technologies, Inc. Verfahren zur befestigung einer zählersequenz an einer nukleinsäureprobe
US9045803B2 (en) 2012-02-29 2015-06-02 Abbott Molecular Inc. Hepatitis B virus typing and resistance assay
EP4155401A1 (de) 2012-03-02 2023-03-29 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
EP2820157B1 (de) 2012-03-02 2019-05-01 Winthrop-University Hospital Verfahren zur verwendung von sondenbasierter pcr-detektion zum messen der konzentration von dna aus zirkulierenden entmethylierten beta-zellen als massstab für beta-zell-verlust bei diabetes
AU2013228226B2 (en) 2012-03-05 2016-06-02 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence by PTO cleavage and extension assay
EP2823060B1 (de) 2012-03-05 2018-02-14 Adaptive Biotechnologies Corporation Festlegung von gepaarten immunrezeptorketten aus frequenzabgestimmten untereinheiten
WO2013139860A1 (en) 2012-03-21 2013-09-26 Roche Diagnostics Gmbh Methods for assessing rna quality
US9803239B2 (en) 2012-03-29 2017-10-31 Complete Genomics, Inc. Flow cells for high density array chips
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
EP2834371B1 (de) 2012-04-05 2019-01-09 The Regents of The University of California Genexpressionspaneel für brustkrebsprognose
US10633707B2 (en) 2012-04-10 2020-04-28 Vib Vzw Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway
US10294529B2 (en) 2012-04-10 2019-05-21 Life Sciences Research Partners Vzw Microsatellite instability markers in detection of cancer
JPWO2013157215A1 (ja) 2012-04-17 2015-12-21 国立大学法人山口大学 子宮体がん発症感受性の判定方法
EP2653558B1 (de) 2012-04-18 2015-10-07 Roche Diagniostics GmbH Verfahren zur Erkennung von Nukleinsäuretargets mithilfe eines statistischen Klassifizierers
EP3524692A1 (de) 2012-04-20 2019-08-14 T2 Biosystems, Inc. Zusammensetzungen und verfahren zur detektion der candida-spezies
SG11201407107VA (en) 2012-05-08 2014-11-27 Adaptive Biotechnologies Corp Compositions and method for measuring and calibrating amplification bias in multiplexed pcr reactions
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
WO2013184754A2 (en) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Spatial sequencing of nucleic acids using dna origami probes
US9628676B2 (en) 2012-06-07 2017-04-18 Complete Genomics, Inc. Imaging systems with movable scan mirrors
US9488823B2 (en) 2012-06-07 2016-11-08 Complete Genomics, Inc. Techniques for scanned illumination
EP2861757B1 (de) 2012-06-14 2019-11-06 Life Technologies Corporation Neuartige zusammensetzungen, verfahren und kits für polymerasekettenreaktionen (pcr)
US20130337442A1 (en) 2012-06-15 2013-12-19 Pioneer Hi-Bred International, Inc. Genetic loci associated with soybean cyst nematode resistance and methods of use
WO2013192100A1 (en) 2012-06-18 2013-12-27 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods and compositions for detecting jc virus
CN104619863A (zh) 2012-07-13 2015-05-13 生命技术公司 采用一组snp的人身份识别
WO2014011928A1 (en) 2012-07-13 2014-01-16 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CN108875312A (zh) 2012-07-19 2018-11-23 哈佛大学校长及研究员协会 利用核酸存储信息的方法
EP2880184B1 (de) 2012-08-03 2021-03-31 California Institute of Technology Multiplexing und quantifizierung in pcr mit reduzierter hardware und reduzierten anforderungen
US9957557B2 (en) 2012-08-13 2018-05-01 Life Genetics Lab, Llc Development of a highly sensitive quantification system for assessing DNA degradation and quality in forensic samples
US10993418B2 (en) 2012-08-13 2021-05-04 Life Genetics Lab, Llc Method for measuring tumor burden in patient derived xenograft (PDX) mice
US9982313B2 (en) 2012-08-17 2018-05-29 Roche Molecular Systems, Inc. Compositions and methods for detection of herpes simplex virus 1 and 2
CA2883219C (en) 2012-08-30 2020-12-29 Gen-Probe Incorporated Multiphase nucleic acid amplification
US9914968B2 (en) 2012-09-26 2018-03-13 Cepheid Honeycomb tube
US10253360B2 (en) 2012-09-28 2019-04-09 Bna Inc. BNA clamp method
CN105189779B (zh) 2012-10-01 2018-05-11 适应生物技术公司 通过适应性免疫受体多样性和克隆性表征进行的免疫能力评估
US10329608B2 (en) 2012-10-10 2019-06-25 Life Technologies Corporation Methods, systems, and computer readable media for repeat sequencing
EP2722399A1 (de) 2012-10-18 2014-04-23 Roche Diagniostics GmbH Verfahren zur Vermeidung von Produkten mit hohem Molekulargewicht während einer Amplifikation
ES2659747T3 (es) 2012-10-18 2018-03-19 F. Hoffmann-La Roche Ag Ensayo de doble sonda para la detección de poblaciones heterogéneas de amplicón
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
ES2640570T3 (es) 2012-10-18 2017-11-03 F. Hoffmann-La Roche Ag Ensayo de doble sonda para la detección de VHC
WO2014068072A1 (en) 2012-10-31 2014-05-08 Institut Gustave-Roussy Identification, assessment and therapy of essential thrombocythemia with resistance to jak2 inhibitors
DK2914741T3 (da) 2012-11-02 2017-11-20 Life Technologies Corp Hidtil ukendte sammensætninger og fremgangsmåder til forbedring af PCR-specificitet
US10314253B2 (en) 2012-12-04 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and compositions for watermelon sex expression
DK2931898T3 (en) 2012-12-12 2016-06-20 Massachusetts Inst Technology CONSTRUCTION AND OPTIMIZATION OF SYSTEMS, PROCEDURES AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
WO2014093701A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
IL239317B (en) 2012-12-12 2022-07-01 Broad Inst Inc Providing, engineering and optimizing systems, methods and compositions for sequence manipulation and therapeutic applications
WO2014093718A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
PT2898075E (pt) 2012-12-12 2016-06-16 Harvard College Manipulação e otimização de sistemas, métodos e composições de enzima melhorados para manipulação de sequências
EP3434776A1 (de) 2012-12-12 2019-01-30 The Broad Institute, Inc. Verfahren, modelle, systeme und vorrichtungen zur identifikation von zielsequenzen für cas-enzyme oder crispr-cas-systeme für zielsequenzen und förderresultate davon
WO2014093714A1 (en) 2012-12-14 2014-06-19 Bio-Rad Laboratories, Inc. Methods and compositions for using oils for analysis and detection of molecules
KR20150098605A (ko) 2012-12-21 2015-08-28 에자이 알앤드디 매니지먼트 가부시키가이샤 퀴놀린 유도체의 비정질 형태 및 그의 제조방법
ES2653642T3 (es) 2012-12-27 2018-02-08 Seegene, Inc. Detección de una secuencia de ácido nucleico diana mediante ensayo sin hibridación dependiente de escisión y extensión de PTO
CN105748499B (zh) 2013-01-31 2018-12-28 吉利德制药有限责任公司 两个抗病毒化合物的联用制剂
WO2014124046A1 (en) 2013-02-08 2014-08-14 Bio-Rad Laboratories, Inc. Affinity-based partition assay for detection of target molecules
EP2959012B1 (de) 2013-02-21 2018-02-14 Qualicon Diagnostics LLC Sequenzen und deren verwendung für den nachweis und die charakterisierung von e.coli o157:h7
AU2014200958B2 (en) 2013-02-25 2016-01-14 Seegene, Inc. Detection of nucleotide variation on target nucleic acid sequence
US9914979B2 (en) 2013-03-04 2018-03-13 Fry Laboratories, LLC Method and kit for characterizing microorganisms
US20140287417A1 (en) 2013-03-08 2014-09-25 Roche Molecular Systems, Inc. EGFR Blood Monitoring
US9873913B2 (en) 2013-03-08 2018-01-23 Roche Molecular Systems, Inc. Mutation testing
EP2971095B1 (de) 2013-03-12 2019-11-20 Life Technologies Corporation Verfahren für universelle reporterbasierte genotypisierung, und reaktionsmischungen und kits zur deren durchführung
WO2014168711A1 (en) 2013-03-13 2014-10-16 Sequenom, Inc. Primers for dna methylation analysis
KR101943623B1 (ko) 2013-03-13 2019-01-30 주식회사 씨젠 멜팅 피크 분석을 이용한 타겟 핵산서열의 정량
US8778609B1 (en) 2013-03-14 2014-07-15 Good Start Genetics, Inc. Methods for analyzing nucleic acids
US20140296080A1 (en) 2013-03-14 2014-10-02 Life Technologies Corporation Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood
US9828629B2 (en) 2013-03-15 2017-11-28 Roche Molecular Systems, Inc. Nucleic acid target identification by structure based probe cleavage
KR102240332B1 (ko) 2013-03-15 2021-04-14 아벨리노 랩 유에스에이, 인크. 대립유전자 검출을 위한 게놈 dna 주형의 개선된 단리 방법
CN105229175A (zh) 2013-03-15 2016-01-06 雅培分子公司 用于扩增和测定rna融合基因变体的方法、区分它们的方法以及有关的引物、探针和试剂盒
US10119134B2 (en) 2013-03-15 2018-11-06 Abvitro Llc Single cell bar-coding for antibody discovery
US10294489B2 (en) 2013-03-15 2019-05-21 Board Of Trustees Of Southern Illinois University Soybean resistant to cyst nematodes
WO2014153408A1 (en) 2013-03-19 2014-09-25 Directed Genomics, Llc Enrichment of target sequences
WO2014160797A1 (en) 2013-03-26 2014-10-02 Genetag Technology, Inc. Dual probe:antiprobe compositions for dna and rna detection
BR112015024752A2 (pt) 2013-03-27 2017-07-18 Cedars Sinai Medical Center mitigação e reversão da fibrose e inflamação através da inibição da função de tl1a e vias de sinalização relacionadas
EP2982762B1 (de) 2013-04-01 2018-08-01 Genomictree, Inc. Verfahren zur nukleinsäureamplifikation mittels eines allelspezifischen reaktiven primers
WO2014172434A1 (en) 2013-04-16 2014-10-23 The Johns Hopkins University Diagnostic and prognostic test for sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (pwss)
WO2014176259A1 (en) 2013-04-22 2014-10-30 Icahn School Of Medicine At Mount Sinai Mutations in pdgfrb and notch3 as causes of autosomal dominant infantile myofibromatosis
WO2014182835A1 (en) 2013-05-09 2014-11-13 Bio-Rad Laboratories, Inc. Magnetic immuno digital pcr assay
CN105264380B (zh) 2013-05-14 2017-09-05 卫材R&D管理有限公司 用于预测和评价子宫内膜癌受试者对乐伐替尼化合物响应性的生物标志
US10059999B2 (en) 2013-06-10 2018-08-28 Monsanto Technology Llc Molecular markers associated with soybean tolerance to low iron growth conditions
KR20160044457A (ko) 2013-06-17 2016-04-25 더 브로드 인스티튜트, 인코퍼레이티드 서열 조작을 위한 탠덤 안내 시스템, 방법 및 조성물의 전달, 조작 및 최적화
RU2716420C2 (ru) 2013-06-17 2020-03-11 Те Брод Инститьют Инк. Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени
AU2014281027A1 (en) 2013-06-17 2016-01-28 Massachusetts Institute Of Technology Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation
EP3011032B1 (de) 2013-06-17 2019-10-16 The Broad Institute, Inc. Freisetzung, manipulation und optimierung von systeme, verfahren und zusammensetzungen für targeting und modellierung von erkrankungen und störungen postmitotischer zellen
SG10201710487VA (en) 2013-06-17 2018-01-30 Broad Inst Inc Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for Targeting Disorders and Diseases Using Viral Components
EP3957743A1 (de) * 2013-06-19 2022-02-23 Luminex Corporation Multiplexierter echtzeithydrolysesondentest
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
DE102013213279B4 (de) 2013-07-06 2024-03-28 Ist Innuscreen Gmbh Universelles Verfahren zur Detektion von diversen Analyten in Form von Nukleinsäuresequenzen
KR101863943B1 (ko) 2013-07-15 2018-06-01 주식회사 씨젠 Ｐｔｏ 절단 및 연장-의존적 고정화 올리고뉴클레오타이드 혼성화를 이용한 타겟 핵산 서열의 검출
EP4105236A1 (de) 2013-07-19 2022-12-21 Cedars-Sinai Medical Center Anti-tl1a (tnfsf15) antikörper zur behandlung von entzündlichen darmerkrankungen
CN105473737B (zh) 2013-07-25 2019-10-25 德诚分子诊断 用于检测细菌污染的方法和组合物
US9926597B2 (en) 2013-07-26 2018-03-27 Life Technologies Corporation Control nucleic acid sequences for use in sequencing-by-synthesis and methods for designing the same
US10093978B2 (en) 2013-08-12 2018-10-09 Genentech, Inc. Compositions for detecting complement factor H (CFH) and complement factor I (CFI) polymorphisms
AU2014309047A1 (en) 2013-08-20 2016-02-11 Qualicon Diagnostics, Llc Sequences and their use for detection of Salmonella enteritidis and/or Salmonella typhimurium
WO2015179773A1 (en) 2014-05-22 2015-11-26 The Scripps Research Institute Tissue molecular signatures of kidney transplant rejections
US10767188B2 (en) 2013-09-25 2020-09-08 Nutech Ventures Methods and compositions for obtaining useful plant traits
CN105683980B (zh) 2013-10-04 2018-08-24 生命科技股份有限公司 在使用终止化学物质的测序中建立分阶段效应模型的方法和系统
AU2014331828B2 (en) 2013-10-09 2020-05-14 Fluoresentric, Inc. Multiplex probes
JP6524073B2 (ja) 2013-10-17 2019-06-05 センター フォー アディクション アンド メンタル ヘルス 抗精神病薬誘導体重増加に関連する遺伝子マーカーおよびその使用のための方法
KR101757473B1 (ko) 2013-10-18 2017-07-13 주식회사 씨젠 ｈＣＴＯ를 이용하는 ＰＴＯ 절단 및 연장 분석에 의한 고상에서의 타겟 핵산 서열 검출
US10655173B2 (en) 2013-10-18 2020-05-19 The Broad Institute, Inc. Spatial and cellular mapping of biomolecules in situ by high-throughput sequencing
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
WO2015056243A1 (en) 2013-10-18 2015-04-23 Institut De Cardiologie De Montreal Genotyping tests and methods for evaluating plasma creatine kinase levels
WO2015061714A1 (en) 2013-10-25 2015-04-30 Life Technologies Corporation Novel compounds for use in pcr systems and applications thereof
US20160272997A1 (en) 2013-10-25 2016-09-22 Pioneer Hi-Bred International, Inc. Stem canker tolerant soybeans and methods of use
KR102293785B1 (ko) 2013-11-15 2021-08-26 아벨리노 랩 유에스에이, 인크. 안과 질환과 관련된 대립유전자의 멀티플렉스 검출 방법
RU2694976C1 (ru) 2013-11-22 2019-07-18 Орион Диагностика Ой Определение нуклеиновых кислот путем амплификации, основанной на встраивании в цепь
NZ718164A (en) 2013-11-27 2017-04-28 Seminis Vegetable Seeds Inc Disease resistance loci in onion
ES2693217T3 (es) 2013-12-02 2018-12-10 Personal Genome Diagnostics Inc. Método para evaluar variantes minoritarias en una muestra
UA121377C2 (uk) 2013-12-04 2020-05-25 Ньюліф Сімбіотікс, Інк. Композиція та виділена methylobacterium для поліпшення продуктивності рослин, їхнє застосування та рослина, покрита вказаною композицією
WO2015085230A1 (en) 2013-12-06 2015-06-11 Bio-Rad Laboratories, Inc. Fusion polymerases
US9476853B2 (en) 2013-12-10 2016-10-25 Life Technologies Corporation System and method for forming microwells
WO2015089419A2 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
US20150176060A1 (en) 2013-12-20 2015-06-25 Roche Molecular Systems, Inc. Method For Coding Of Multiple PCR Reactions For Assay Recognition
US9637791B2 (en) 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
US9243289B2 (en) 2013-12-23 2016-01-26 Roche Molecular Systems, Inc. Method for screening reagents used in PCR assays
MX2016009590A (es) 2014-01-24 2017-05-09 Lam Therapeutics Inc Composiciones de apilimod y métodos para usar las mismas.
PL3102230T3 (pl) 2014-02-08 2021-11-15 F.Hoffmann-La Roche Ag Sposoby leczenia choroby Alzheimera
US9822396B2 (en) 2014-02-13 2017-11-21 Bio-Rad Laboratories, Inc. Chromosome conformation capture in partitions
CA2939580C (en) 2014-02-21 2020-07-21 Syngenta Participations Ag Genetic loci associated with increased fertility in maize
US9721061B2 (en) 2014-02-21 2017-08-01 President And Fellows Of Harvard College De novo design of allosteric proteins
NZ630710A (en) 2014-02-27 2016-03-31 Seminis Vegetable Seeds Inc Compositions and methods for peronospora resistance in spinach
CN106462668A (zh) 2014-02-28 2017-02-22 戒毒及精神卫生中心 用于治疗和预防抗精神病药物诱导的增重的组合物和方法
EP3114240B1 (de) 2014-03-05 2019-07-24 Adaptive Biotechnologies Corporation Verfahren unter verwendung von randomerhaltigen synthetischen molekülen
KR102207922B1 (ko) 2014-03-06 2021-01-26 삼성전자주식회사 반코마이신 저항성 엔테로코커스 특이적인 프라이머 세트, 그를 포함하는 조성물 및 시료 중 반코마이신 저항성 엔테로코커스 속 미생물을 검출하는 방법
EP3736344A1 (de) 2014-03-13 2020-11-11 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
EP3692795A1 (de) 2014-03-17 2020-08-12 Newleaf Symbiotics, Inc. Zusammensetzungen und verfahren zur verbesserung der tomatenproduktion
WO2015147370A1 (en) 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
WO2015153732A2 (en) 2014-04-01 2015-10-08 Cornell University Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
EP3126524B1 (de) 2014-04-04 2020-07-22 Affymetrix, Inc. Verbesserte zusammensetzungen und verfahren für molekularinversionsprobenassays
ES2777529T3 (es) 2014-04-17 2020-08-05 Adaptive Biotechnologies Corp Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
US20160053302A1 (en) 2014-04-22 2016-02-25 Roche Molecular Systems, Inc. Method for visual identification of pcr solutions for accurate reaction setup
EP2942401A1 (de) 2014-05-09 2015-11-11 Lifecodexx AG Nachweis von aus einem spezifischen Zelltyp stammender DNA
EP2942400A1 (de) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex-Nachweis von DNA, die aus einem spezifischen Zelltyp herrührt
EP3521454A1 (de) 2014-05-09 2019-08-07 LifeCodexx AG Nachweis von aus einem spezifischen zelltyp stammender dna und zugehörige verfahren
US11053548B2 (en) 2014-05-12 2021-07-06 Good Start Genetics, Inc. Methods for detecting aneuploidy
EP3146076A4 (de) 2014-05-22 2018-05-09 The Scripps Research Institute Mit subklinischer nierentransplantatabstossung assoziierte genexpressionsprofile
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
AU2015263998A1 (en) 2014-05-22 2016-12-08 Northwestern University Gene expression profiles associated with sub-clinical kidney transplant rejection
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
JP6442534B2 (ja) * 2014-06-02 2018-12-19 ベース４ イノベーション リミテッド ヌクレオチド多型の検出方法
US10640833B2 (en) 2014-06-26 2020-05-05 University Of Florida Research Foundation, Inc. Rapid detection of infectious agents
US10316369B2 (en) 2014-06-27 2019-06-11 Seminis Vegetable Seeds, Inc. Methods and assays for male sterile watermelon
JP2017521654A (ja) 2014-06-27 2017-08-03 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ ヒトペギウイルス２（ＨＰｇＶ−２）を検出するための組成物および方法
EP3167060B1 (de) 2014-07-10 2021-11-24 Fluoresentric, Inc. Dna-amplifikationstechnologie
WO2016014493A1 (en) 2014-07-22 2016-01-28 Bio-Rad Laboratories, Inc. Buffers for use with polymerases
CN106715718B (zh) 2014-07-24 2021-07-06 雅培分子公司 用于检测和分析结核分枝杆菌的组合物和方法
KR102456013B1 (ko) 2014-07-30 2022-10-18 에프. 호프만-라 로슈 아게 고밀도 지질단백질(hdl)-상승 제제 또는 hdl-모방 제제에 의한 치료법에 대한 반응성을 예측하기 위한 유전 표지
EP3180426B1 (de) 2014-08-17 2019-12-25 The Broad Institute, Inc. Gemonbearbeitung mit cas9-nickasen
EP3183574B1 (de) 2014-08-18 2022-03-30 The Texas A&M University System Beta-laktamase als biomarker zum spezifischen nachweis von tuberkulosekomplexbakterien
HRP20221047T1 (hr) 2014-08-28 2022-11-11 Eisai R&D Management Co., Ltd. Derivat kinolina visoke čistoće i postupak za njegovu proizvodnju
WO2016040446A1 (en) 2014-09-10 2016-03-17 Good Start Genetics, Inc. Methods for selectively suppressing non-target sequences
KR102541849B1 (ko) 2014-09-15 2023-06-09 에이비비트로, 엘엘씨 고-처리량 뉴클레오티드 라이브러리 서열결정
EP3224595A4 (de) 2014-09-24 2018-06-13 Good Start Genetics, Inc. Prozesssteuerung für erhöhte robustheit von genetischen assays
US10370673B2 (en) 2014-09-26 2019-08-06 Purecircle Sdn Bhd Single nucleotide polymorphism (SNP) markers for stevia
AU2015327756B2 (en) 2014-09-30 2018-01-04 Genetic Technologies Limited Methods for assessing risk of developing breast cancer
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
EP3005862A1 (de) 2014-10-10 2016-04-13 Seminis Vegetable Seeds, Inc. Melonenpflanzen mit verbesserter krankheitstoleranz
WO2016060974A1 (en) 2014-10-13 2016-04-21 Life Technologies Corporation Methods, systems, and computer-readable media for accelerated base calling
US20170253921A1 (en) 2014-10-13 2017-09-07 Life Technologies Corporation Methods, kits & compositions for determining gene copy numbers
DE102015220401B4 (de) 2014-10-20 2022-12-29 Gen-Probe Incorporated Erythrozyten-Lyselösung
EP3212790B1 (de) 2014-10-29 2020-03-25 Adaptive Biotechnologies Corp. Hochmultiplexierter gleichzeitiger nachweis von für adaptive gepaarte immunrezeptorheterodimere codierenden nukleinsäuren aus einer vielzahl von proben
KR102287811B1 (ko) 2014-10-31 2021-08-09 삼성전자주식회사 2개 표면을 결합시키는 방법 및 그에 의하여 제조된 구조체, 및 상기 구조체를 포함하는 미세유동 장치
AU2015342869A1 (en) 2014-11-07 2017-06-15 AI Therapeutics, Inc. Apilimod for use in the treatment of renal cancer
WO2016077366A1 (en) 2014-11-10 2016-05-19 Genentec, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
US11198855B2 (en) 2014-11-13 2021-12-14 The Board Of Trustees Of The University Of Illinois Bio-engineered hyper-functional “super” helicases
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
US9745618B2 (en) 2014-11-19 2017-08-29 Roche Molecular Systems, Inc. Photoblocked probes and methods for sequential detection of nucleic acids
US9920381B2 (en) 2014-12-02 2018-03-20 Roche Molecular Systems, Inc. Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus
WO2016093838A1 (en) 2014-12-11 2016-06-16 New England Biolabs, Inc. Enrichment of target sequences
WO2016094874A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Escorted and functionalized guides for crispr-cas systems
EP3985115A1 (de) 2014-12-12 2022-04-20 The Broad Institute, Inc. Geschützte guide-rnas (pgrnas)
US9909169B2 (en) 2014-12-17 2018-03-06 Roche Molecular Systems, Inc. Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
AU2015369725A1 (en) 2014-12-24 2017-06-29 Massachusetts Institute Of Technology CRISPR having or associated with destabilization domains
EP3271480B8 (de) 2015-01-06 2022-09-28 Molecular Loop Biosciences, Inc. Abtastung auf strukturelle varianten
US10337072B2 (en) 2015-01-08 2019-07-02 The Board Of Trustees Of The University Of Illinois Copy number detection and methods
US20180215801A1 (en) 2015-01-29 2018-08-02 Board Of Trustees Of Michigan State University Cryptic polypeptides and uses thereof
US10421993B2 (en) 2015-02-11 2019-09-24 Paragon Genomics, Inc. Methods and compositions for reducing non-specific amplification products
JP6620160B2 (ja) 2015-02-20 2019-12-11 タカラ バイオ ユーエスエー， インコーポレイテッド 単一細胞の迅速かつ正確な分注、視覚化及び解析のための方法
JP6792546B2 (ja) 2015-02-25 2020-11-25 エーザイ・アール・アンド・ディー・マネジメント株式会社 キノリン誘導体の苦味抑制方法
CA2978226A1 (en) 2015-03-04 2016-09-09 Merck Sharpe & Dohme Corp. Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
CN105936930A (zh) 2015-03-04 2016-09-14 松下知识产权经营株式会社 Dna检测方法和dna检测装置
CN105969655A (zh) 2015-03-10 2016-09-28 松下知识产权经营株式会社 多个核酸靶标的分析方法
US10066256B2 (en) 2015-03-17 2018-09-04 Bio-Rad Laboratories, Inc. Detection of genome editing
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9957393B2 (en) 2015-03-30 2018-05-01 Enzo Biochem, Inc. Monoazo dyes with cyclic amine as fluorescence quenchers
WO2016161273A1 (en) 2015-04-01 2016-10-06 Adaptive Biotechnologies Corp. Method of identifying human compatible t cell receptors specific for an antigenic target
US11035849B2 (en) 2015-04-13 2021-06-15 The Translational Genomics Research Institute Predicting the occurrence of metastatic cancer using epigenomic biomarkers and non-invasive methodologies
CN104845967B (zh) 2015-04-15 2020-12-11 苏州新海生物科技股份有限公司 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
EP3889274A3 (de) 2015-04-28 2022-01-19 Monsanto Technology LLC Verfahren und zusammensetzungen zur herstellung von verkürzten maispflanzen
UA126326C2 (uk) 2015-04-30 2022-09-21 Монсанто Текнолоджі Елелсі Спосіб відбору рослини каноли, стійкої до кили капустяних
EP3295345B1 (de) 2015-05-14 2023-01-25 Life Technologies Corporation Barcodesequenzen sowie zugehörige systeme und verfahren
ES2759477T3 (es) 2015-05-29 2020-05-11 Hoffmann La Roche Un procedimiento de inactivación de microbios por anhídrido citracónico
JP2018517559A (ja) 2015-06-05 2018-07-05 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ 吸着性バイオプロセス清澄化剤並びにその製造及び使用方法
EP3307071B1 (de) 2015-06-10 2020-04-22 Newleaf Symbiotics, Inc. Verwendungsverfahren von antimykotischen methylobacterium-zusammensetzungen
ES2842205T3 (es) 2015-06-15 2021-07-13 Cepheid Integración de la purificación del ADN y la medición de su metilación y la medición conjunta de mutaciones y/o niveles de expresión de ARNm en un cartucho de reacción automático
CN107801379B (zh) 2015-06-16 2021-05-25 卫材R&D管理有限公司 抗癌剂
US9790490B2 (en) 2015-06-18 2017-10-17 The Broad Institute Inc. CRISPR enzymes and systems
FI3430134T3 (fi) 2015-06-18 2023-01-13 Uusia CRISPR-entsyymejä ja järjestelmiä
EP3436575A1 (de) 2015-06-18 2019-02-06 The Broad Institute Inc. Neuartige crispr-enzyme und -systeme
RU2600873C1 (ru) * 2015-06-24 2016-10-27 Закрытое акционерное общество "ЕВРОГЕН" Способ идентификации нативных пар фрагментов днк или рнк, присутствующих в одних и тех же живых клетках
EP3322483A4 (de) 2015-07-14 2019-01-02 Abbott Molecular Inc. Zusammensetzungen und verfahren zum nachweis von wirkstoffresistenter tuberkulose
EP3124619B1 (de) 2015-07-31 2019-03-06 Menicon Co., Ltd Reagenzien, verfahren und kit zur glaukomdiagnose über hunderassen hinweg und innerhalb von hunderassen
KR20210048600A (ko) 2015-08-17 2021-05-03 쿠라 온콜로지, 인크. 파르네실전달효소 억제제를 이용하여 암환자를 치료하는 방법
US10767189B2 (en) 2015-08-18 2020-09-08 Monsanto Technology Llc Methods for producing cotton plants with enhanced drought tolerance and compositions thereof
WO2017040520A1 (en) 2015-08-31 2017-03-09 Hitachi Chemical Co., Ltd. Molecular methods for assessing urothelial disease
US10448595B2 (en) 2015-09-03 2019-10-22 Seminis Vegetable Seeds, Inc. Downy mildew resistant lettuce plants
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
WO2017044744A2 (en) 2015-09-10 2017-03-16 Monsanto Technology Llc Methods for producing corn plants with downy mildew resistance and compositions thereof
CA2999888C (en) 2015-09-24 2024-04-09 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
MX2018003534A (es) 2015-09-25 2019-04-25 Abvitro Llc Proceso de alto rendimiento para identificacion de blanco de receptor de celula t de secuencias de receptor de celula t apareadas de manera natural.
US11266730B2 (en) 2015-09-29 2022-03-08 The General Hospital Corporation Methods of treating and diagnosing disease using biomarkers for BCG therapy
WO2017070605A1 (en) 2015-10-22 2017-04-27 The Broad Institute Inc. Type vi-b crispr enzymes and systems
WO2017075294A1 (en) 2015-10-28 2017-05-04 The Board Institute Inc. Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
US11273151B2 (en) 2015-11-04 2022-03-15 Icahn School Of Medicine At Mount Sinai Methods of treating tumors and cancer, and identifying candidate subjects for such treatment
DK3168309T3 (da) 2015-11-10 2020-06-22 Eurofins Lifecodexx Gmbh Detektion af føtale kromosomale aneuploidier under anvendelse af dna-regioner med forskellig metylering mellem fosteret og det gravide hunkøn
JP6685396B2 (ja) 2015-11-20 2020-04-22 シージーン アイエヌシー 標的分析物質に対するデータセットの補正方法
EP3387107B1 (de) 2015-12-11 2020-08-12 Spartan Bioscience Inc. Röhrchenverschlusssystem und verfahren zur nukleinsäureamplifikation
KR102110985B1 (ko) 2015-12-15 2020-05-14 주식회사 씨젠 타겟 핵산 서열에 대한 시그널 추출
WO2017106731A1 (en) 2015-12-18 2017-06-22 Monsanto Technology Llc Methods for producing corn plants with northern leaf blight resistance and compositions thereof
US20190233814A1 (en) 2015-12-18 2019-08-01 The Broad Institute, Inc. Novel crispr enzymes and systems
WO2017106447A1 (en) 2015-12-18 2017-06-22 Pioneer Hi-Bred International, Inc. Genetic loci associated with reproductive growth phenotypes in soybean and methods of use
US10689689B2 (en) * 2015-12-28 2020-06-23 Roche Molecular Systems, Inc. Generic method for the stabilization of specific RNA
AU2017207341A1 (en) 2016-01-12 2018-08-02 Interleukin Genetics, Inc. Methods for predicting response to treatment
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
US20190032104A1 (en) 2016-01-21 2019-01-31 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
JP7007298B2 (ja) 2016-01-25 2022-02-10 バイオ―ラッド ヨーロッパ ゲーエムベーハー デジタル微生物学
AU2017212152B2 (en) 2016-01-28 2019-07-11 The University Of Melbourne Methods for assessing risk of developing colorectal cancer
KR102300738B1 (ko) 2016-02-05 2021-09-10 주식회사 씨젠 타겟 분석물질에 대한 데이터 세트의 노이즈 수준 감축 방법
CA3004914A1 (en) 2016-02-05 2017-08-10 Pioneer Hi-Bred International, Inc. Genetic loci associated with brown stem rot resistance in soybean and methods of use
WO2017138484A1 (ja) 2016-02-09 2017-08-17 栄研化学株式会社 標的核酸を検出する方法およびそれに用いる核酸プローブ
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US10655190B2 (en) 2016-03-11 2020-05-19 Roche Molecular Systems, Inc. Compositions and methods for detection of Zika virus
CN109462996A (zh) 2016-03-17 2019-03-12 西达-赛奈医疗中心 通过rnaset2诊断炎性肠病的方法
EP3440221A1 (de) 2016-04-06 2019-02-13 Life Technologies Corporation Zusammensetzungen, verfahren und kits zur synthese und zum nachweis von nukleinsäuren
JP2019517780A (ja) 2016-04-14 2019-06-27 ティー２ バイオシステムズ，インコーポレーテッド 複合試料における増幅のための方法及びシステム
AU2017253107B2 (en) 2016-04-19 2023-07-20 Massachusetts Institute Of Technology CPF1 complexes with reduced indel activity
SG10202010311SA (en) 2016-04-19 2020-11-27 Broad Inst Inc Novel Crispr Enzymes and Systems
WO2017189308A1 (en) 2016-04-19 2017-11-02 The Broad Institute Inc. Novel crispr enzymes and systems
WO2017184968A1 (en) 2016-04-22 2017-10-26 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
EP3448881B1 (de) 2016-04-26 2023-06-07 Icahn School of Medicine at Mount Sinai Behandlung von hippo-pfad-mutanten tumoren und verfahren zur identifizierung von probanden als kandidaten für die behandlung
EP3449015A1 (de) 2016-04-27 2019-03-06 Mira DX, Inc. Immunbasierte behandlung von patienten mit krebs der kras-variante
CA3021914A1 (en) 2016-04-27 2017-11-02 Gen-Probe Incorporated Blood cell lysis reagent
US10619205B2 (en) 2016-05-06 2020-04-14 Life Technologies Corporation Combinatorial barcode sequences, and related systems and methods
EP3978625A1 (de) 2016-05-12 2022-04-06 Pioneer Hi-Bred International, Inc. Verfahren zur gleichzeitigen gepoolten genotypisierung von pflanzen
US20190176153A1 (en) 2016-05-18 2019-06-13 Roche Sequencing Solutions, Inc. Quantitative real time pcr amplification using an electrowetting-based device
US10612101B2 (en) 2016-05-27 2020-04-07 Roche Molecular Systems, Inc. Compositions and methods for detection of Mycoplasma genitalium
WO2017202894A1 (en) 2016-05-27 2017-11-30 Roche Diagnostics Gmbh Compositions and methods for detection of trichomonas vaginalis
WO2017210437A1 (en) 2016-06-01 2017-12-07 Life Technologies Corporation Methods and systems for designing gene panels
KR102218776B1 (ko) 2016-06-10 2021-02-22 주식회사 씨젠 태깅 올리고뉴클레오타이드의 제공 방법
CN109477150B (zh) 2016-06-16 2023-03-31 生命技术公司 用于检测微生物的组合物、方法和试剂盒
CA3028158A1 (en) 2016-06-17 2017-12-21 The Broad Institute, Inc. Type vi crispr orthologs and systems
EP3472354A4 (de) 2016-06-17 2020-01-01 California Institute of Technology Nukleinsäurereaktionen sowie zugehörige verfahren und zusammensetzungen
US11155857B2 (en) 2016-06-27 2021-10-26 Dana-Farber Cancer Institute, Inc. Methods for measuring RNA translation rates
WO2018005873A1 (en) 2016-06-29 2018-01-04 The Broad Institute Inc. Crispr-cas systems having destabilization domain
EP3479101B1 (de) 2016-06-30 2023-12-13 Seegene, Inc. Vorrichtung und verfahren zur verstärkung von nukleinsäure
EP3487616B1 (de) 2016-07-21 2023-08-09 Takara Bio USA, Inc. Multi-z-bildgebung von wells von multi-well-geräten und flüssigkeitsabgabe in die wells
US10626454B2 (en) 2016-07-27 2020-04-21 SeqMatic, LLC Compositions and methods for nucleic acid amplification and analysis
AU2017301881A1 (en) 2016-07-29 2019-02-07 Juno Therapeutics, Inc. Methods for assessing the presence or absence of replication competent virus
JP6999645B2 (ja) 2016-08-02 2022-02-04 エフ．ホフマン－ラ ロシュ アーゲー 核酸の増幅及び検出／定量の効率を改良するためのヘルパーオリゴヌクレオチド
US10837067B2 (en) 2016-08-11 2020-11-17 Monsanto Technology Llc Methods and compositions for producing corn plants with resistance to late wilt
EP3504342A1 (de) 2016-08-26 2019-07-03 Life Technologies Corporation Kontrollen für nukleinsäureextraktion und -amplifikation sowie verfahren zur verwendung davon
KR102468174B1 (ko) 2016-09-15 2022-11-17 에프. 호프만-라 로슈 아게 멀티플렉스 pcr 수행 방법
CN109890983A (zh) 2016-09-23 2019-06-14 生命技术公司 用于评估免疫应答的组合物和方法
US10487358B2 (en) 2016-09-23 2019-11-26 Grail, Inc. Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
JP6929354B2 (ja) 2016-09-24 2021-09-01 アブビトロ， エルエルシー 親和性−オリゴヌクレオチドコンジュゲートおよびその使用
AU2017232187B2 (en) 2016-09-30 2023-11-09 Seminis Vegetable Seeds, Inc. Xanthomonas resistant brassica oleracea plants
DE102016120124B8 (de) 2016-10-21 2018-08-23 Gna Biosolutions Gmbh Verfahren zum Durchführen einer Polymerase-Kettenreaktion und Vorrichtung zum Ausführen des Verfahrens
AU2017353838A1 (en) 2016-11-03 2019-05-23 Kura Oncology, Inc. Farnesyltransferase inhibitors for use in methods of treating cancer
CA3040930A1 (en) 2016-11-07 2018-05-11 Grail, Inc. Methods of identifying somatic mutational signatures for early cancer detection
US11031099B2 (en) 2016-11-09 2021-06-08 Roche Molecular Systems, Inc. Detection of sequence variants
US10793923B2 (en) 2016-11-09 2020-10-06 Roche Molecular Systems, Inc. Compositions and methods for detection of BK virus
CA3046636A1 (en) 2016-12-12 2018-06-21 Cepheid Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
US20180163270A1 (en) 2016-12-12 2018-06-14 Cepheid Integrated immuno-pcr and nucleic acid analysis in an automated reaction cartridge
EP3551768B1 (de) 2016-12-12 2024-03-06 Grail, LLC Verfahren zur markierung und amplifizierung von rna-template-molekülen zur herstellung von sequenzierungsbibliotheken
US20190211377A1 (en) 2016-12-22 2019-07-11 Roche Molecular Systems, Inc. Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
EP3559255A1 (de) 2016-12-23 2019-10-30 Grail, Inc. Verfahren zur hocheffizienten bibliothek-herstellung unter verwendung von doppelsträngigen adaptern
EP4001428B1 (de) 2016-12-29 2023-11-22 Seegene, Inc. Verfahren zur reduzierung der primer-dimer-bildung und erhöhung des amplifikationswirkungsgrades
WO2018129214A1 (en) 2017-01-04 2018-07-12 Complete Genomics, Inc. Stepwise sequencing by non-labeled reversible terminators or natural nucleotides
EP3568493B1 (de) 2017-01-10 2021-03-24 Paragon Genomics, Inc. Verfahren und zusammensetzungen zur verringerung von redundanten molekularen barcodes in primerextensionsreaktionen
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
US9956215B1 (en) 2017-02-21 2018-05-01 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
MX2019009821A (es) 2017-02-21 2019-12-02 Kura Oncology Inc Metodos para tratar cancer con inhibidores de farnesiltransferasa.
CA3053875A1 (en) 2017-03-08 2018-09-13 Etablissement Francais Du Sang Rhd gene allele associated with a weak d phenotype and its uses
WO2018170436A1 (en) 2017-03-16 2018-09-20 Jacobs Farm Del Cabo Basil with high tolerance to downy mildew
WO2018177325A1 (en) 2017-03-29 2018-10-04 Crown Bioscience Inc. (Taicang) System and method for determining cetuximab sensitivity on gastric cancer
WO2018183918A1 (en) 2017-03-30 2018-10-04 Grail, Inc. Enhanced ligation in sequencing library preparation
WO2018183897A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Higher target capture efficiency using probe extension
US11584958B2 (en) 2017-03-31 2023-02-21 Grail, Llc Library preparation and use thereof for sequencing based error correction and/or variant identification
US11572591B2 (en) 2017-04-26 2023-02-07 The Translational Genomics Research Institute Methods and assays for subtyping Staphylococcus aureus clonal complex 8 strains
CN108823287B (zh) 2017-04-28 2019-04-12 厦门大学 一种检测靶核酸序列的方法
WO2018200980A1 (en) 2017-04-28 2018-11-01 Avellino Lab Usa, Inc. Methods for detecting alleles associated with keratoconus
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
US20190093155A1 (en) 2017-05-25 2019-03-28 Roche Molecular Systems, Inc. Multiplex Nucleic Acid Amplification Assay
EP3631012B1 (de) 2017-05-26 2022-06-08 AbVitro LLC Hochdurchsatzsequenzierung von polynukleotid und transkriptomanalyse
RU2022103603A (ru) 2017-06-23 2022-03-11 Инскрипта, Инк. Направляемые нуклеиновыми кислотами нуклеазы
US10760137B2 (en) 2017-07-18 2020-09-01 Roche Molecular Systems, Inc. Compositions and methods for detection of Babesia
TWI829642B (zh) 2017-07-24 2024-01-21 美商寬騰矽公司 高強度經標記之反應物組合物及用於定序之方法
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
TW201919628A (zh) 2017-08-07 2019-06-01 美商庫拉腫瘤技術股份有限公司 以法尼基轉移酶(farnesyltransferase)抑制劑治療癌症之方法
US11591645B2 (en) 2017-08-31 2023-02-28 Seegene, Inc. Evaluation of performance of components using a pair of dimer-forming primers
US20200263170A1 (en) 2017-09-14 2020-08-20 Grail, Inc. Methods for preparing a sequencing library from single-stranded dna
CA3076915A1 (en) 2017-09-27 2019-04-04 AI Therapeutics, Inc. Therapeutic methods relating to hsp90 inhibitors
US11028439B2 (en) 2017-09-27 2021-06-08 Abbott Molecular Inc. Assay for detecting hepatitis B virus (HBV)
WO2019067973A1 (en) 2017-09-28 2019-04-04 Grail, Inc. ENRICHMENT OF SHORT NUCLEIC ACID FRAGMENTS IN THE PREPARATION OF SEQUENCING LIBRARIES
KR102345601B1 (ko) 2017-09-29 2021-12-30 주식회사 씨젠 Pto 절단 및 연장-의존적 연장 분석에 의한 타겟 핵산 서열의 검출
WO2019063661A1 (en) 2017-09-29 2019-04-04 Roche Diagnostics Gmbh COMPOSITIONS AND METHODS FOR THE DETECTION OF TRICHOMONAS VAGINALIS
EP3628059B1 (de) 2017-10-03 2023-04-12 Abbott Molecular Inc. Test zum nachweis des humanen immunschwächevirus (hiv)
WO2019070854A1 (en) 2017-10-03 2019-04-11 Abbott Molecular Inc. ASSAY FOR DETECTION OF HEPATITIS C VIRUS (HCV)
WO2019084055A1 (en) 2017-10-23 2019-05-02 Massachusetts Institute Of Technology CLASSIFICATION OF GENETIC VARIATION FROM UNICELLULAR TRANSCRIPTOMS
EP3710601A1 (de) 2017-11-13 2020-09-23 Life Technologies Corporation Zusammensetzungen, verfahren und kits zur detektion von harnweg-mikroorganismen
WO2019113506A1 (en) 2017-12-07 2019-06-13 The Broad Institute, Inc. Methods and compositions for multiplexing single cell and single nuclei sequencing
WO2019118652A1 (en) 2017-12-12 2019-06-20 Essenlix Corporation Sample manipulation and assay with rapid temperature change
WO2019118925A1 (en) 2017-12-15 2019-06-20 Grail, Inc. Methods for enriching for duplex reads in sequencing and error correction
US20190237161A1 (en) 2017-12-22 2019-08-01 Grail, Inc. Error removal using improved library preparation methods
US11242568B2 (en) 2017-12-29 2022-02-08 City Of Hope DNA methylation diagnostic test for breast cancer
KR102369388B1 (ko) 2018-01-05 2022-03-02 주식회사 씨젠 시료에서 M. tuberculosis, M. bovis 및 M. bovis BCG의 존재 또는 부존재를 결정하는 방법
CA3088866A1 (en) 2018-01-09 2019-07-18 Abbott Molecular Inc. Assay for detecting chlamydia trachomatis, neisseria gonorrhoeae, trichomonas vaginalis, and mycoplasma genitalium
MX2020007852A (es) 2018-01-25 2021-01-29 Biogen Ma Inc Metodos para el tratamiento de la atrofia muscular espinal.
KR20200115579A (ko) 2018-01-30 2020-10-07 라이프 테크놀로지스 코포레이션 스마트 분자 분석 시스템의 워크플로우에서 사용하기 위한 기기, 장치 및 소모품
WO2019152747A1 (en) 2018-01-31 2019-08-08 Juno Therapeutics, Inc. Methods and reagents for assessing the presence or absence of replication competent virus
CA3226165A1 (en) 2018-02-09 2019-08-15 Genentech, Inc. Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases
DE102018001586A1 (de) 2018-02-28 2019-10-17 Agct Gmbh Verfahren zur Detektion der Amplifikation einer Nukleinsäure mit verbesserter Spezifität
EP3759248A1 (de) 2018-02-26 2021-01-06 AGCT GmbH Agverfahren zur amplifikation einer nukleinsäure mit verbesserter spezifität
WO2019178337A1 (en) 2018-03-14 2019-09-19 Luminex Corporation Multiplex amplification of nucleic acids employing lowering of denaturation temperature and increasing the annealing temperature
CN111868238A (zh) 2018-03-21 2020-10-30 豪夫迈·罗氏有限公司 用于甲基化-dNTPs的效率高的和有效参入的DNA聚合酶
WO2019191679A1 (en) 2018-03-30 2019-10-03 Incyte Corporation Biomarkers for inflammatory skin disease
KR102464501B1 (ko) 2018-04-20 2022-11-17 주식회사 씨젠 샘플 내 복수의 타겟 핵산 서열의 검출을 위한 방법 및 장치
WO2019213619A1 (en) 2018-05-04 2019-11-07 Abbott Laboratories Hbv diagnostic, prognostic, and therapeutic methods and products
US11268102B2 (en) 2018-05-16 2022-03-08 University Of Florida Research Foundation, Incorporated Compositions and methods for identifying and selecting brachytic locus in solanaceae
GB2597566B (en) 2018-06-13 2023-02-01 Gen Probe Inc Compositions and methods for detecting group B streptococcus nucleic acid
EP3820610A1 (de) 2018-07-12 2021-05-19 Luminex Corporation Systeme und verfahren zur durchführung variabler probenvorbereitung und analyseverfahren
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
CN112770776A (zh) 2018-07-30 2021-05-07 瑞德库尔有限责任公司 用于样品处理或分析的方法和系统
CA3106975A1 (en) 2018-08-01 2020-02-06 Gen-Probe Incorporated Compositions and methods for detecting nucleic acids of epstein-barr virus
US20210317429A1 (en) 2018-08-20 2021-10-14 The Broad Institute, Inc. Methods and compositions for optochemical control of crispr-cas9
EP3847277A1 (de) 2018-09-06 2021-07-14 Hygiena, LLC Sequenzen und ihre verwendung für den nachweis und die charakterisierung von escherichia coli serotyp o157:h7
US11739306B2 (en) 2018-09-13 2023-08-29 Roche Molecular Systems, Inc. Mutant DNA polymerase(s) with improved strand displacement ability
EP3856934A2 (de) 2018-09-27 2021-08-04 Gen-Probe Incorporated Zusammensetzungen und verfahren zur detektion von bordetella-pertussis- und bordetella-parapertussis-nukleinsäure
ES2939143T3 (es) 2018-10-05 2023-04-19 Eisai R&D Man Co Ltd Biomarcadores para una politerapia que comprende lenvatinib y everolimus
EP3861346A1 (de) 2018-10-05 2021-08-11 Eisai R&D Management Co., Ltd. Biomarker für eine therapie mit einer sorafenib-verbindung
US20220401460A1 (en) 2018-10-10 2022-12-22 Dana-Farber Cancer Institute, Inc. Modulating resistance to bcl-2 inhibitors
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
EP3874059A1 (de) 2018-10-29 2021-09-08 Koninklijke Nederlandse Akademie van Wetenschappen Volllängen-rna-sequenzierung einer einzelzelle
US20220002396A1 (en) 2018-11-01 2022-01-06 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US20220017973A1 (en) 2018-12-03 2022-01-20 Roche Molecular Systems, Inc. Compositions and methods for detection of candida auris
SG11202105441WA (en) 2018-12-13 2021-06-29 Dna Script Direct oligonucleotide synthesis on cells and biomolecules
US11384344B2 (en) 2018-12-17 2022-07-12 The Broad Institute, Inc. CRISPR-associated transposase systems and methods of use thereof
CN113286883A (zh) 2018-12-18 2021-08-20 格里尔公司 使用rna分析以检测疾病的方法
WO2020132090A1 (en) 2018-12-18 2020-06-25 Abbott Molecular Inc. Assay for detecting human papilloma virus (hpv)
WO2020127620A1 (en) 2018-12-20 2020-06-25 F. Hoffmann-La Roche Ag Detection of target nucleic acid by solid-phase molography
EP3906317A1 (de) 2019-01-03 2021-11-10 DNA Script Eintopfsynthese von sätzen von oligonukleotiden
CA3126761C (en) 2019-01-15 2023-01-10 Seminis Vegetable Seeds, Inc. Green bean plants with improved disease resistance
JP2022518056A (ja) 2019-01-23 2022-03-11 クアンタム－エスアイ インコーポレイテッド 高強度標識されたシーケンシング用の反応組成物および方法
KR102097721B1 (ko) 2019-01-24 2020-04-06 주식회사 시선바이오머티리얼스 태그서열 snp를 이용한 단일 검출 프로브 기반 다중 표적 검출방법
WO2020167715A1 (en) 2019-02-12 2020-08-20 Biogen Ma Inc. Biomarkers of progressive multifocal leukoencephalopathy
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
MX2021009682A (es) 2019-02-15 2021-11-12 Incyte Corp Biomarcadores de cinasa 2 dependientes de ciclinas y sus usos.
US20220142983A1 (en) 2019-03-01 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
EP3937780A4 (de) 2019-03-14 2022-12-07 InSilixa, Inc. Verfahren und systeme zur zeitgesteuerten fluoreszenzbasierten detektion
US20220177863A1 (en) 2019-03-18 2022-06-09 The Broad Institute, Inc. Type vii crispr proteins and systems
US11634782B2 (en) 2019-03-20 2023-04-25 Hygiena, Llc Quantification of microorganisms in samples and methods of determining quantification conditions thereof
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
AU2020254492A1 (en) 2019-03-29 2021-11-11 Kura Oncology, Inc. Methods of treating Squamous Cell Carcinomas with farnesyltransferase inhibitors
US20220168296A1 (en) 2019-04-01 2022-06-02 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US20220175848A1 (en) 2019-04-01 2022-06-09 The Broad Institute, Inc. Methods and compositions for cell therapy
WO2020205491A1 (en) 2019-04-05 2020-10-08 Hygiena, Llc Sequences and their use for detection and characterization of genus cronobacter
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
CN113785073A (zh) 2019-05-02 2021-12-10 豪夫迈·罗氏有限公司 基于链分离温度利用dITP进行RNA靶标相比于DNA靶标的优先性/选择性扩增
WO2020223583A1 (en) 2019-05-02 2020-11-05 Kura Oncology, Inc. Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors
EP3966351A1 (de) 2019-05-07 2022-03-16 F. Hoffmann-La Roche AG Zusammensetzungen und verfahren zum nachweis von neisseria gonorroheae
US20220235340A1 (en) 2019-05-20 2022-07-28 The Broad Institute, Inc. Novel crispr-cas systems and uses thereof
US20220249660A1 (en) 2019-06-06 2022-08-11 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
WO2020251306A1 (en) 2019-06-14 2020-12-17 Seegene, Inc. Computer-implemented method for collaborative development of reagents for detection of target nucleic acids
CN114174540A (zh) 2019-07-25 2022-03-11 豪夫迈·罗氏有限公司 用于检测爱泼斯坦巴尔病毒(ebv)的组合物和方法
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
US20230193259A1 (en) 2019-08-13 2023-06-22 Universidade De Santiago De Compostela Compounds and methods for the treatment of cancer
PE20221010A1 (es) 2019-08-14 2022-06-15 Incyte Corp Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2
WO2021037399A1 (en) 2019-08-27 2021-03-04 F. Hoffmann-La Roche Ag Compositions and methods for amplification and detection of hepatitis b virus rna, including hbv rna transcribed from cccdna
EP3569717A3 (de) 2019-08-28 2020-04-08 Boehringer Ingelheim Vetmedica GmbH Diagnostisches verfahren zur dedektion von dna und rna viren mittels polymerase kettenreaktion in einem beheizten reaktionsvolumen
US20220298501A1 (en) 2019-08-30 2022-09-22 The Broad Institute, Inc. Crispr-associated mu transposase systems
AR119934A1 (es) 2019-09-12 2022-01-19 Ai Therapeutics Inc Inhibidores de pikfyve para terapia contra el cáncer
CA3155451A1 (en) 2019-09-23 2021-04-01 Universiteit Gent Probe and method for str-genotyping
US11542513B2 (en) 2019-09-26 2023-01-03 Seminis Vegetable Seeds, Inc. Lettuce plants having resistance to Nasonovia ribisnigri biotype Nr:1
CN115176032A (zh) 2019-10-11 2022-10-11 生命科技股份有限公司 用于评估微生物群体的组合物和方法
JP2022551668A (ja) 2019-10-11 2022-12-12 インサイト・コーポレイション Ｃｄｋ２阻害剤としての二環式アミン
US11441167B2 (en) 2019-11-20 2022-09-13 Roche Molecular Systems, Inc. Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
US20230050863A1 (en) 2019-12-09 2023-02-16 Roche Molecular Systems, Inc. Dicationic fluorescent dyes
WO2021133916A1 (en) 2019-12-23 2021-07-01 Abbott Laboratories Compositions and methods for detecting picobirnavirus
US11060141B1 (en) 2019-12-23 2021-07-13 Stilla Technologies Multiplex drop-off digital polymerase chain reaction methods
JP2023508100A (ja) 2019-12-27 2023-02-28 エフ． ホフマン－ラ ロシュ エージー． メチシリン耐性黄色ブドウ球菌を検出するための組成物および方法
WO2021138325A1 (en) 2019-12-30 2021-07-08 Abbott Laboratories Compositions and methods for detecting bunyavirus
US20220356537A1 (en) 2019-12-31 2022-11-10 Roche Molecular Systems, Inc. Quantitative pcr screening of inducible prophage from bacterial isolates
EP3911769B1 (de) 2020-02-18 2022-11-02 Life Technologies Corporation Zusammensetzungen und verfahren zur detektion von viralen sequenzen
EP4114985A1 (de) 2020-03-04 2023-01-11 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von sars-cov-2-nukleinsäure
US20210332448A1 (en) 2020-03-09 2021-10-28 Janssen Pharmaceutica Nv Compositions and methods for quantifying integration of recombinant vector nucleic acid
JP2023516472A (ja) 2020-03-09 2023-04-19 エフ． ホフマン－ラ ロシュ アーゲー 重症急性呼吸器症候群コロナウイルス２（ｓａｒｓ－ｃｏｖ－２）、インフルエンザａ及びインフルエンザｂを検出するための組成物及び方法
US20230110203A1 (en) 2020-03-13 2023-04-13 Medimmune Limited Therapeutic methods for the treatment of subjects with risk alelles in il33
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19
US20230242971A1 (en) 2020-05-08 2023-08-03 Roche Sequencing Solutions, Inc. Removal of excess oligonucleotides from a reation mixture
US10941453B1 (en) 2020-05-20 2021-03-09 Paragon Genomics, Inc. High throughput detection of pathogen RNA in clinical specimens
KR20230019872A (ko) 2020-05-27 2023-02-09 지네틱 테크놀로지스 리미티드 코로나바이러스 감염에 대한 중증 반응의 발생 위험을 평가하는 방법
EP4163397A1 (de) 2020-06-05 2023-04-12 Seegene, Inc. Probentransportkit zum nachweis von atemwegspathogenen und verfahren zum nachweis von atemwegspathogenen damit
AU2021204717A1 (en) 2020-07-15 2022-02-03 Seminis Vegetable Seeds, Inc. Green Bean Plants with Improved Disease Resistance
AU2021322710A1 (en) 2020-08-06 2023-02-02 F. Hoffmann-La Roche Ag Compositions and methods for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-2), influenza A, and influenza B
EP4204546A1 (de) 2020-08-31 2023-07-05 City of Hope Neue zelllinien, verfahren zur herstellung natürlicher killerzellen und verwendungen davon
WO2022078792A1 (en) 2020-10-12 2022-04-21 Nunhems B.V. Parthenocarpic watermelon plants
WO2022090323A1 (en) 2020-10-29 2022-05-05 Dna Script Enzymatic synthesis of polynucleotide probes
WO2022096451A1 (en) 2020-11-09 2022-05-12 Nunhems B.V. Parthenocarpic watermelon plants
US20240003918A1 (en) 2020-11-30 2024-01-04 Enigma Biointelligence, Inc. Non-invasive assessment of alzheimer's disease
WO2022117784A1 (en) 2020-12-04 2022-06-09 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
JP7209980B2 (ja) 2020-12-11 2023-01-23 東洋紡株式会社 Ｄｎａポリメラーゼの５’→３’エキソヌクレアーゼ活性ドメインに特異的に結合する抗体
WO2022136477A1 (en) 2020-12-22 2022-06-30 F. Hoffmann-La Roche Ag Methods for performing multiplexed real-time pcr with the use of large stokes shift fluorescent dyes
US20220205020A1 (en) 2020-12-30 2022-06-30 Roche Molecular Systems, Inc. Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
EP4278002A2 (de) 2021-01-18 2023-11-22 Life Technologies Corporation Zusammensetzungen, kits und verfahren zur direkten amplifikation aus biologischen rohproben
EP4281589A1 (de) 2021-01-25 2023-11-29 Life Technologies Corporation Zusammensetzungen, kits und verfahren zum nachweis viraler variantensequenzen
WO2022167570A1 (en) 2021-02-05 2022-08-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of human parainfluenza viruses 1-4 (hpiv 1-4)
US20220290221A1 (en) 2021-03-15 2022-09-15 Roche Molecular Systems, Inc. Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
EP4314350A1 (de) 2021-03-23 2024-02-07 Life Technologies Corporation Zusammensetzungen, kits und verfahren für den variantenresistenten nachweis von zielvirussequenzen
WO2022233930A1 (en) 2021-05-06 2022-11-10 F. Hoffmann-La Roche Ag Compositions and methods for detecting hepatitis delta virus by a dual-target assay
AU2022273052A1 (en) 2021-05-14 2023-11-30 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
WO2022269023A1 (en) 2021-06-25 2022-12-29 F. Hoffmann-La Roche Ag Methods for performing temperature multiplexed pcr with increased sensitivity
AU2022301661A1 (en) 2021-06-30 2024-02-08 Nunhems B.V. Methods for selecting watermelon plants and plant parts comprising a modified dwarf14 gene
AU2022304654A1 (en) 2021-07-01 2023-12-14 Gen-Probe Incorporated Enzyme formulations and reaction mixtures for nucleic acid amplification
KR20240033032A (ko) 2021-07-09 2024-03-12 세페이드 높은 수준의 다중화 반응 용기, 시약 점적 장치 및 관련 방법
FR3125824A1 (fr) 2021-07-30 2023-02-03 Bforcure Dispositif et procédé de détection multiplexée de séquences d’acides nucléiques
WO2023014729A1 (en) 2021-08-02 2023-02-09 Life Technologies Corporation Compositions, kits, and methods for detection of nucleic acid sequence loads
WO2023020938A1 (en) 2021-08-16 2023-02-23 Nunhems B.V. Lettuce plant having delayed bolting
WO2023043280A1 (ko) 2021-09-17 2023-03-23 주식회사 씨젠 합성 비자연 염기를 포함하는 태그 올리고뉴클레오타이드를 이용한 타겟 핵산 서열의 검출
US20230121442A1 (en) 2021-10-06 2023-04-20 Johnson & Johnson Consumer Inc. Method of Quantifying Product Impact on Human Microbiome
WO2023069604A1 (en) 2021-10-20 2023-04-27 Life Technologies Corporation Compositions, kits, and methods for quantification of nucleic acid sequences using an internal quantitative standard
IL310714A (en) 2021-10-26 2024-04-01 Caribou Biosciences Inc Real-time exonuclease-conjugated endonuclease activity assay
WO2023079032A1 (en) 2021-11-05 2023-05-11 F. Hoffmann-La Roche Ag Compositions and methods for detection of malaria
WO2023089186A1 (en) 2021-11-22 2023-05-25 F. Hoffmann-La Roche Ag Compositions and methods for detecting vana and/or vanb genes associated with multidrug resistance
WO2023104812A1 (en) 2021-12-09 2023-06-15 F. Hoffmann-La Roche Ag Mass based detection of pcr amplicons
US20230193310A1 (en) 2021-12-10 2023-06-22 Seminis Vegetabe Seeds, Inc. Lettuce plants having resistance to downy mildew
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
WO2023118399A1 (en) 2021-12-24 2023-06-29 F. Hoffmann-La Roche Ag Improved detection of lamp amplification products
TW202342023A (zh) 2022-03-07 2023-11-01 美商英塞特公司 Ｃｄｋ２抑制劑之固體形式、鹽及製備方法
US20230348985A1 (en) 2022-03-21 2023-11-02 CarexDx, Inc. Methods for non-invasively monitoring organ health in cross-species transplantation
US11680293B1 (en) 2022-04-21 2023-06-20 Paragon Genomics, Inc. Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules
US20230404003A1 (en) 2022-06-21 2023-12-21 Seminis Vegetable Seeds, Inc. Novel qtls conferring resistance to cucumber mosaic virus
WO2023248185A1 (en) 2022-06-24 2023-12-28 Mobidiag Oy Compact detection system
WO2024002924A2 (en) 2022-06-28 2024-01-04 F. Hoffmann-La Roche Ag Fluorescent dyes with large stokes shift
WO2024006924A1 (en) 2022-06-29 2024-01-04 Life Technologies Corporation Systems and methods for analyte detection from multiplexed assays
WO2024003114A1 (en) 2022-06-29 2024-01-04 Actome Gmbh Detection of biomolecules in single cells
WO2024006927A1 (en) 2022-06-29 2024-01-04 Life Technologies Corporation Compositions, kits, and methods for detecting nucleic acids using intra-channel multiplexing
WO2024003332A1 (en) 2022-06-30 2024-01-04 F. Hoffmann-La Roche Ag Controlling for tagmentation sequencing library insert size using archaeal histone-like proteins
WO2024003260A1 (en) 2022-06-30 2024-01-04 F. Hoffmann-La Roche Ag Compositions and methods for detecting lymphogranuloma venereum (lgv) serovars of chlamydia trachomatis
WO2024015766A1 (en) 2022-07-12 2024-01-18 Topogene Inc. Scalable, submicron-resolution replication of dna arrays
WO2024030985A1 (en) 2022-08-04 2024-02-08 Abbott Laboratories Assays for detecting monkeypox virus
WO2024042042A1 (en) 2022-08-24 2024-02-29 F. Hoffmann-La Roche Ag Compositions and methods for detecting monkeypox virus
WO2024044352A1 (en) 2022-08-26 2024-02-29 The General Hospital Corporation Methods and compositions for prognosis and treatment of dilated cardiomyopathy and heart failure
WO2024054925A1 (en) 2022-09-09 2024-03-14 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318981A (en) * 1980-04-24 1982-03-09 Miles Laboratories, Inc. Homogeneous specific binding assay employing an intramolecularly modulated photogenic enzyme substrate label
US4358535A (en) * 1980-12-08 1982-11-09 Board Of Regents Of The University Of Washington Specific DNA probes in diagnostic microbiology
CA1219824A (en) † 1981-04-17 1987-03-31 David C. Ward Modified nucleotides and methods of preparing and using same
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1185177A (en) * 1981-07-17 1985-04-09 Larry E. Morrison Non-radiative energy transfer immunochemical technique
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
FR2540122B1 (fr) 1983-01-27 1985-11-29 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
GB8311018D0 (en) † 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4743535A (en) * 1984-11-07 1988-05-10 Miles Inc. Hybridization assay employing labeled probe and anti-hybrid
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4820630A (en) * 1984-11-23 1989-04-11 Digene Diagnostics, Incorporated Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
DK150841C (da) 1984-12-19 1988-07-11 Medicotest Systemer As Forbindelsesled til etablering af elektrisk forbindelse med en engangshudelektrode
DK171161B1 (da) 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4780405A (en) * 1985-06-25 1988-10-25 Siska Diagnostics, Inc. Carbonic anhydrase inhibitor-tagged nucleic acid probes
SE450813B (sv) † 1985-07-23 1987-08-03 Volcano Int Medical Ab Kneskydd med festbara stoddelar
FR2586704B1 (fr) 1985-09-04 1987-12-18 Centre Nat Rech Scient Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation et a un groupe chimique activable, leur synthese et leurs applications a titre de nucleases artificielles specifiques de sequences. centre national de la recherche scientifique (cnrs)
US5011769A (en) * 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4996143A (en) * 1985-12-23 1991-02-26 Syngene, Inc. Fluorescent stokes shift probes for polynucleotide hybridization
EP0232967B1 (de) 1986-01-10 1993-04-28 Amoco Corporation Kompetitiver homogener Test
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer
CA1284931C (en) * 1986-03-13 1991-06-18 Henry A. Erlich Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
GB8612087D0 (en) * 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
JPS638396A (ja) 1986-06-30 1988-01-14 Wakunaga Pharmaceut Co Ltd ポリ標識化オリゴヌクレオチド誘導体
CA1340806C (en) * 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US4889818A (en) * 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
CA1338457C (en) * 1986-08-22 1996-07-16 Henry A. Erlich Purified thermostable enzyme
US4914210A (en) * 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
CA1323293C (en) * 1987-12-11 1993-10-19 Keith C. Backman Assay using template-dependent nucleic acid probe reorganization
FR2627590A1 (fr) * 1988-02-24 1989-08-25 Ire Celltarg Sa Sonde d'acides nucleiques comportant un nucleotide terminal modifie chimiquement en 5(prime) (oh) en vue de son marquage non radioactif et procedes de preparation
US5082830A (en) 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
JP2856804B2 (ja) * 1988-03-24 1999-02-10 ユニバーシティ オブ アイオワ リサーチ ファウンデイション 標識された相補的核酸プローブを開裂する触媒反応の補因子としての活性に基づく核酸配列検出のための触媒ハイブリッド形成系
ATE114726T1 (de) * 1988-05-10 1994-12-15 Du Pont Verfahren zum schnellen nachweis von nukleinsäuren.
WO1989011548A1 (en) † 1988-05-20 1989-11-30 Cetus Corporation Immobilized sequence-specific probes
AU629845B2 (en) * 1988-08-30 1992-10-15 Abbott Laboratories Detection and amplification of target nucleic acid sequences
US4997928A (en) * 1988-09-15 1991-03-05 E. I. Du Pont De Nemours And Company Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
WO1990012115A1 (en) * 1989-03-21 1990-10-18 Collaborative Research, Inc. A dna diagnostic test using an exonuclease activity
US5108892A (en) * 1989-08-03 1992-04-28 Promega Corporation Method of using a taq dna polymerase without 5'-3'-exonuclease activity
KR950013953B1 (ko) * 1990-01-26 1995-11-18 애보트 래보라토리즈 리가제 연쇄 반응에 적용가능한 표적 핵산의 증폭 방법
AU7268691A (en) * 1990-03-07 1991-09-12 Molecular Diagnostics, Inc. Ribonuclease scission chain reaction
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase

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ES2209033T5 (es) 2009-04-16
DE69133329T2 (de) 2004-08-05
US5487972A (en) 1996-01-30
JP2825976B2 (ja) 1998-11-18
ES2209033T3 (es) 2004-06-16
EP1302549A2 (de) 2003-04-16
US7445900B2 (en) 2008-11-04
US20080171315A1 (en) 2008-07-17
EP0543942A1 (de) 1993-06-02
DE69133329T3 (de) 2009-07-09
EP1302549A3 (de) 2004-01-14
CA2088683A1 (en) 1992-02-07
US5210015A (en) 1993-05-11
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AU666837B2 (en) 1996-02-29
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ATE252110T1 (de) 2003-11-15
US6214979B1 (en) 2001-04-10
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