DE69217398T2 - Verfahren zur Herstellung von 9-deoxo-9(z)-hydroxyiminoerythromycin A - Google Patents

Verfahren zur Herstellung von 9-deoxo-9(z)-hydroxyiminoerythromycin A

Info

Publication number
DE69217398T2
DE69217398T2 DE69217398T DE69217398T DE69217398T2 DE 69217398 T2 DE69217398 T2 DE 69217398T2 DE 69217398 T DE69217398 T DE 69217398T DE 69217398 T DE69217398 T DE 69217398T DE 69217398 T2 DE69217398 T2 DE 69217398T2
Authority
DE
Germany
Prior art keywords
hydroxyiminoerythromycin
deoxo
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69217398T
Other languages
English (en)
Other versions
DE69217398D1 (de
Inventor
Robert R Wilkening
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69217398D1 publication Critical patent/DE69217398D1/de
Application granted granted Critical
Publication of DE69217398T2 publication Critical patent/DE69217398T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DE69217398T 1991-03-15 1992-03-12 Verfahren zur Herstellung von 9-deoxo-9(z)-hydroxyiminoerythromycin A Expired - Lifetime DE69217398T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/669,809 US5912331A (en) 1991-03-15 1991-03-15 Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A

Publications (2)

Publication Number Publication Date
DE69217398D1 DE69217398D1 (de) 1997-03-27
DE69217398T2 true DE69217398T2 (de) 1997-07-10

Family

ID=24687831

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69217398T Expired - Lifetime DE69217398T2 (de) 1991-03-15 1992-03-12 Verfahren zur Herstellung von 9-deoxo-9(z)-hydroxyiminoerythromycin A

Country Status (6)

Country Link
US (1) US5912331A (de)
EP (1) EP0503949B1 (de)
JP (1) JPH0689018B2 (de)
CA (1) CA2062933C (de)
CY (1) CY2096B1 (de)
DE (1) DE69217398T2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2696608B2 (ja) * 1993-05-19 1998-01-14 ファイザー・インク． アジスロマイシンの中間物質
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin
DE69824590T2 (de) * 1997-07-08 2005-06-30 Sandoz Industrial Products S.A., Granollers Solvate von erythromycin a oxim
US6258785B1 (en) * 1998-12-02 2001-07-10 Pfizer Inc. Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
US6239113B1 (en) * 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
US7056893B2 (en) * 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
FR2802534B1 (fr) * 1999-12-20 2002-02-01 Merial Sas Procede pour preparer et isoler la 9-deoxo-9 (z)- hydroxyiminoerythromycine a
US6590084B2 (en) * 1999-12-20 2003-07-08 Merial Process for preparing and isolating 9-deoxo-9 (Z)-hydroxyiminoerythromycin A
FR2806724B1 (fr) * 2000-03-24 2003-12-05 Merial Sas Procede pour la preparation de derives 9-deoxo-8a-aza- (8a-alkyl)-8a-homoerythromycine a a partir de la 9-deoxo-9 (z)-hydroxyiminoerythromycine a

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869444A (en) * 1972-10-10 1975-03-04 Abbott Lab Esters of erythromycin oxime
US3923784A (en) * 1973-09-10 1975-12-02 Hoffmann La Roche Erythromycin a derivatives
US3979511A (en) * 1974-05-23 1976-09-07 Abbott Laboratories Inhibitors of reverse transcriptase enzymes
US4152424A (en) * 1975-07-23 1979-05-01 Hoffmann-La Roche Inc. Antibiotic 1745A/X and methods for the production thereof
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
YU43116B (en) * 1979-04-02 1989-04-30 Pliva Pharm & Chem Works Process for preparing 11-aza-4-o-cladinosyl-6-o-desosaminyl-15-ethyl-7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl-oxacyclopentadecane-2-one(11-aza-10-deox
FR2473525A1 (fr) * 1980-01-11 1981-07-17 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
SI8110592A8 (en) * 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
DE3473593D1 (en) * 1983-04-04 1988-09-29 Allied Corp Process for the production of o-substituted oximes
US4492688A (en) * 1983-11-25 1985-01-08 Pfizer Inc. Antibacterial cyclic ethers of 9-deoxo-9a-aza-9a-homoerythromycin A and intermediates therefor
US4464527A (en) * 1983-06-30 1984-08-07 Pfizer Inc. Antibacterial 9-deoxo-9a-alkyl-9a-aza-9a-homoerythromycin A derivatives and intermediates therefore
US4465674A (en) * 1983-09-06 1984-08-14 Pfizer Inc. Azahomoerythromycin D derivative and intermediates therefor
ATE38519T1 (de) * 1983-09-06 1988-11-15 Pfizer Azahomoerythromycin-b-derivate und zwischenprodukte.
US4518590A (en) * 1984-04-13 1985-05-21 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical compositions and therapeutic method
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
DE3534731A1 (de) * 1985-09-28 1987-04-09 Bayer Ag Verfahren zur herstellung von hydroxybenzaldoxim-o-ethern
YU44599B (en) * 1986-09-12 1990-10-31 Pliva Pharm & Chem Works Process for preparing complex of n-methyl-11-aza-10-deoxo-10-dihydroeritromicine a and 11-aza-10-deoxo-10-dihydroeritromicine a with metals
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
DK90788A (da) * 1987-02-24 1988-08-25 Beecham Group Plc Erythromycinderivater
WO1989000576A1 (en) * 1987-07-09 1989-01-26 Pfizer Inc. Azithromycin dihydrate
HU198913B (en) * 1987-09-03 1989-12-28 Pliva Pharm & Chem Works Process for producing 10-dihydro-10-deoxo-11-aza-erythronolide a-derivatives and pharmaceutical compositions containing them as active components
GB8721165D0 (en) * 1987-09-09 1987-10-14 Beecham Group Plc Chemical compounds
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
MX13723A (es) * 1987-11-10 1993-05-01 Pfizer Procedimiento para preparar derivados de 9-desoxo-9a-alil- y propargil-9a-aza-9a-homoeritromicina a

Also Published As

Publication number Publication date
CY2096B1 (en) 2002-04-05
CA2062933A1 (en) 1992-09-16
DE69217398D1 (de) 1997-03-27
EP0503949B1 (de) 1997-02-12
CA2062933C (en) 2001-01-16
EP0503949A1 (de) 1992-09-16
US5912331A (en) 1999-06-15
JPH0570475A (ja) 1993-03-23
JPH0689018B2 (ja) 1994-11-09

Similar Documents

Publication Publication Date Title
DE69214889T2 (de) Verfahren zur Herstellung von Bisphenol A
DE69233790D1 (de) Verfahren zur Herstellung von Fullerenen
DE69128009T2 (de) Verfahren zur Herstellung von Tetrabrombisphenol A
DE59209291D1 (de) Verfahren zur Herstellung von Brenzcatechinen
DE69214227D1 (de) Verfahren zur Herstellung von Polyphenylsilsesquioxanen
DE69217398T2 (de) Verfahren zur Herstellung von 9-deoxo-9(z)-hydroxyiminoerythromycin A
DE59205077D1 (de) Verfahren zur Herstellung von Chlorfluornitrobenzolen
DE69214745T2 (de) Verfahren zur Herstellung von Bisphenol A
DE69032378T2 (de) Ein Verfahren zur Herstellung von Dibenzoxazolylthiophenen
DE59205092D1 (de) Verfahren zur Herstellung von 2-Nitro-5-fluor- bzw. -5-chlor-phenol
DE59205946D1 (de) Verfahren zur Herstellung von 2-Aminomethylpiperidin
DE59206083D1 (de) Verfahren zur Herstellung von p-Dichlorbenzol
DE59206271D1 (de) Verfahren zur Herstellung von 2-Chlorpyridinen
DE69221586T2 (de) Verfahren zur Herstellung von Oximinosilanverbindung
DE69216125D1 (de) Verfahren zur Herstellung von 2-Exo-methylenpenam-Derivaten
DE69228840T2 (de) Verfahren zur Herstellung von Citraconsäureimiden
DE69214914D1 (de) Verfahren zur Herstellung von 4-Amino-3-Fluorobenzotrifluorid
DE59108999D1 (de) Verfahren zur Herstellung von N-Alkylsulfonylaminosulfonylharnstoffen
DE69221698D1 (de) Verfahren zur Herstellung von Sulfonylharnstoffen
DE59208718D1 (de) Verfahren zur Herstellung von Imidazothiazolon-Derivaten
DE69218729T2 (de) Verfahren zur Herstellung von (+)-Estronderivaten
DE69115958D1 (de) Verfahren zur Herstellung von 5-Hydroxy-Hydantoin
DE69216490T2 (de) Verfahren zur Herstellung von Methoxy-Methyl-Silanen
DE69232916T2 (de) Verfahren zur Herstellung von 2-Amino-3-nitro-5-halogenopyridin
DE59206151D1 (de) Verfahren zur Herstellung von 2-Chlorpyridinen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US