DE69229703D1 - Wiederhergestellte Influenza-Virosomen mit immunostimulierenden und immunoverstärkenden Eigenschaften und diese enthaltende Impfstoffe - Google Patents
Wiederhergestellte Influenza-Virosomen mit immunostimulierenden und immunoverstärkenden Eigenschaften und diese enthaltende ImpfstoffeInfo
- Publication number
- DE69229703D1 DE69229703D1 DE69229703T DE69229703T DE69229703D1 DE 69229703 D1 DE69229703 D1 DE 69229703D1 DE 69229703 T DE69229703 T DE 69229703T DE 69229703 T DE69229703 T DE 69229703T DE 69229703 D1 DE69229703 D1 DE 69229703D1
- Authority
- DE
- Germany
- Prior art keywords
- immunostabilizing
- immunostimulatory
- restored
- properties
- irivs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
- C12N2770/32434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91107527 | 1991-05-08 | ||
EP91107647 | 1991-05-10 | ||
PCT/EP1992/001014 WO1992019267A1 (en) | 1991-05-08 | 1992-05-08 | Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69229703D1 true DE69229703D1 (de) | 1999-09-09 |
DE69229703T2 DE69229703T2 (de) | 2000-04-27 |
Family
ID=26128845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69229703T Expired - Lifetime DE69229703T2 (de) | 1991-05-08 | 1992-05-08 | Wiederhergestellte Influenza-Virosomen mit immunostimulierenden und immunoverstärkenden Eigenschaften und diese enthaltende Impfstoffe |
Country Status (11)
Country | Link |
---|---|
US (1) | US5565203A (de) |
EP (1) | EP0538437B1 (de) |
JP (1) | JPH06500128A (de) |
AT (1) | ATE182791T1 (de) |
AU (1) | AU655823B2 (de) |
CA (1) | CA2086831C (de) |
DE (1) | DE69229703T2 (de) |
DK (1) | DK0538437T3 (de) |
ES (1) | ES2135406T3 (de) |
GR (1) | GR3031520T3 (de) |
WO (1) | WO1992019267A1 (de) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993001833A1 (en) * | 1991-07-17 | 1993-02-04 | Commonwealth Scientific And Industrial Research Organisation | Improved vaccine |
FR2711670B1 (fr) | 1993-10-22 | 1996-01-12 | Pasteur Institut | Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite. |
US6727230B1 (en) | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
US6004579A (en) * | 1995-09-14 | 1999-12-21 | Lxr Biotechnology, Inc. | Compositions which inhibit apoptosis, methods of making the compositions and uses thereof |
KR100536983B1 (ko) * | 1996-05-08 | 2006-06-29 | 니카 헬스 프로덕츠 리미티드 | 유전자물질을전달용양이온비로좀 |
JP2002508748A (ja) * | 1997-05-01 | 2002-03-19 | カイロン コーポレイション | アジュバントとしてのウイルス様粒子の使用 |
AU7915398A (en) * | 1997-05-23 | 1998-12-11 | Schwiez. Serum-& Impfinstitut Bern | An influenza enveloped dna vaccine |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
BR0016472A (pt) * | 1999-12-17 | 2002-08-20 | Cápsula de ignição indutivamente ativável para sistemas de retenção de ocupantes de assento | |
US7407663B2 (en) * | 2000-06-29 | 2008-08-05 | Lipid Sciences, Inc. | Modified immunodeficiency virus particles |
US7439052B2 (en) | 2000-06-29 | 2008-10-21 | Lipid Sciences | Method of making modified immunodeficiency virus particles |
US7407662B2 (en) * | 2000-06-29 | 2008-08-05 | Lipid Sciences, Inc. | Modified viral particles with immunogenic properties and reduced lipid content |
US20090017069A1 (en) | 2000-06-29 | 2009-01-15 | Lipid Sciences, Inc. | SARS Vaccine Compositions and Methods of Making and Using Them |
AUPQ846900A0 (en) * | 2000-06-29 | 2000-07-27 | Aruba International Pty Ltd | A vaccine |
US6991727B2 (en) | 2001-06-25 | 2006-01-31 | Lipid Sciences, Inc. | Hollow fiber contactor systems for removal of lipids from fluids |
US7033500B2 (en) | 2001-06-25 | 2006-04-25 | Lipid Sciences, Inc. | Systems and methods using multiple solvents for the removal of lipids from fluids |
US20060060520A1 (en) | 2001-06-25 | 2006-03-23 | Bomberger David C | Systems and methods using a solvent for the removal of lipids from fluids |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US20040176283A1 (en) * | 2002-04-01 | 2004-09-09 | Robinson John A. | Methods and compositions for the design of synthetic vaccines |
EP1578443B1 (de) | 2002-11-20 | 2011-01-12 | Bestewil Holding B.V. | Zusammensetzungen mit antigen-komplexen,verfahren zu ihrer herstellung und verfahren zur verwendung derantigen-komplexe zur vakzinierung |
US7491395B2 (en) | 2002-11-20 | 2009-02-17 | Bestewil Holding B.V. | Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination |
EP1447080A1 (de) | 2003-02-13 | 2004-08-18 | Bestewil Holding B.V. | Methode zur Herstellung von Virosomen-artigen Partikeln |
CA2515779A1 (en) | 2003-02-14 | 2004-09-02 | The Curators Of The University Of Missouri | Contraceptive method and compositions related to proteasomal interference |
AR056245A1 (es) | 2003-06-19 | 2007-10-03 | Bestewil Holding Bv | Membranas virales reconstituidas funcionales que contienen un coadyuvante |
US9603921B2 (en) | 2004-10-27 | 2017-03-28 | Janssen Vaccines Ag | Virosome particles comprising antigens from influenza virus and hepatitis b virus |
PE20061329A1 (es) | 2004-12-15 | 2006-12-08 | Neuralab Ltd | Anticuerpos ab humanizados para mejorar la cognicion |
EP1797895A1 (de) | 2005-12-16 | 2007-06-20 | Pevion Biotech Ltd. | Adjuvantsystem bestehend aus Virosomen und Liposomen |
WO2007099387A1 (en) | 2006-03-03 | 2007-09-07 | Mymetics Corporation | Virosome-like vesicles comprising gp41-derived antigens |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
KR20090080977A (ko) * | 2006-10-17 | 2009-07-27 | 메디뮨 엘엘씨 | 바이러스 지질 성분에 영향을 미치는 방법 |
EP1938835A1 (de) | 2006-12-29 | 2008-07-02 | Pevion Biotech AG | Nichtspezifische immunostimulierende Wirkstoffe |
ES2337113B1 (es) * | 2007-04-17 | 2011-01-24 | Centre De Recerca En Sanitat Animal (Cresa) | Empleo de la hemaglutinina del virus de la peste porcina africana como adyuvante. |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
EP2014279A1 (de) | 2007-06-22 | 2009-01-14 | Pevion Biotech AG | Virosomen enthaltend Haemagglutinin, das von über Zelllinien hergestellten Influenza-Viren stammt, Zusammensetzungen, Herstellungsverfahren, Verwendung davon |
SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
EP2058002A1 (de) | 2007-10-31 | 2009-05-13 | Bestewil Holding B.V. | Rekonstituierte Virushüllen des Respiratory Syncytial Virus und Anwendung als Impfstoff für Respiratory Syncytial Virus |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
EP2393509A1 (de) | 2009-02-06 | 2011-12-14 | Mymetics Corporation | Gp41-spaltung |
EA021191B1 (ru) | 2009-02-06 | 2015-04-30 | Майметикс Корпорейшн | НОВЫЕ АНТИГЕНЫ gp41 |
DE102009056883B4 (de) * | 2009-12-03 | 2012-08-16 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
CL2012001399A1 (es) | 2009-12-03 | 2013-03-08 | Novartis Ag | Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion. |
PL2356983T3 (pl) * | 2009-12-03 | 2013-08-30 | Novartis Ag | Cyrkulacja komponentów w czasie homogenizacji emulsji |
PL2343052T3 (pl) | 2009-12-03 | 2013-11-29 | Novartis Ag | Hydrofilowa filtracja podczas produkcji adiuwantów do szczepionek |
DE102009056884B4 (de) | 2009-12-03 | 2021-03-18 | Novartis Ag | Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben |
WO2011128720A1 (en) | 2010-04-14 | 2011-10-20 | Mymetics Corporation | Trans-activator of transcription protein |
CU20100144A7 (es) | 2010-07-06 | 2012-06-21 | Centro Inmunologia Molecular | Composiciones vacunales a base de sticholisina encapsulada en liposomas |
CN103154251A (zh) | 2010-09-30 | 2013-06-12 | 佛兰瓦克斯有限责任公司 | 病毒体颗粒的生产 |
AU2011336467A1 (en) | 2010-12-01 | 2013-07-04 | Spinal Modulation, Inc. | Agent delivery systems for selective neuromodulation |
CA2866465A1 (en) | 2012-03-06 | 2013-09-12 | Crucell Holland B.V. | Improved vaccination against influenza |
EP3016679B1 (de) * | 2013-07-02 | 2019-03-27 | Janssen Vaccines & Prevention B.V. | Verfahren zur herstellung von virosomen |
MX2017002658A (es) | 2014-09-02 | 2017-09-19 | Cadila Healthcare Ltd | Composiciones sinergicas de virosomas de influenza reconstituidos inmunoestimulantes con inmunopotenciadores y vacunas que los contienen. |
KR102277013B1 (ko) | 2014-09-12 | 2021-07-14 | 베스테윌 홀딩 비.브이. | 아쥬반트화된 비로좀을 제공하는 방법 및 이에 의해 수득가능한 아쥬반트화된 비로좀 |
AU2016341619B9 (en) | 2015-10-19 | 2020-01-16 | Cadila Healthcare Limited | New adjuvant and vaccine composition containing the same |
US11523988B2 (en) | 2018-11-29 | 2022-12-13 | Catalent U.K. Swindon Zydis Limited | Oral dispersible vaccine comprising virosomes |
CN114075567A (zh) * | 2020-08-21 | 2022-02-22 | 广州恩宝生物医药科技有限公司 | 优化的表达新型冠状病毒抗原的核苷酸序列及其应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4148876A (en) * | 1975-09-29 | 1979-04-10 | Burroughs Wellcome Co. | Biological preparations |
US4201767A (en) * | 1978-11-08 | 1980-05-06 | Merck & Co., Inc. | Viral liposome particle |
US4199565A (en) * | 1979-03-26 | 1980-04-22 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
EP0047480B1 (de) * | 1980-09-05 | 1986-02-05 | Institut Armand Frappier | Bildung eines Immunosoms, das ausschliesslich aus Virusantigenen, die auf einer künstlichen Membran rekonstruiert sind, hergestellt wird |
US4731237A (en) * | 1983-11-07 | 1988-03-15 | The Wistar Institute | Immune response to virus induced by anti-idiotype antibodies |
US4663161A (en) * | 1985-04-22 | 1987-05-05 | Mannino Raphael J | Liposome methods and compositions |
JPH04500203A (ja) * | 1988-08-25 | 1992-01-16 | ザ リポソーム カンパニー,インコーポレイテッド | インフルエンザワクチンおよび新規なアジュバント |
-
1992
- 1992-05-08 AU AU17456/92A patent/AU655823B2/en not_active Expired
- 1992-05-08 CA CA002086831A patent/CA2086831C/en not_active Expired - Lifetime
- 1992-05-08 ES ES92910072T patent/ES2135406T3/es not_active Expired - Lifetime
- 1992-05-08 EP EP92910072A patent/EP0538437B1/de not_active Expired - Lifetime
- 1992-05-08 DE DE69229703T patent/DE69229703T2/de not_active Expired - Lifetime
- 1992-05-08 WO PCT/EP1992/001014 patent/WO1992019267A1/en active IP Right Grant
- 1992-05-08 JP JP4509497A patent/JPH06500128A/ja active Pending
- 1992-05-08 AT AT92910072T patent/ATE182791T1/de active
- 1992-05-08 DK DK92910072T patent/DK0538437T3/da active
-
1993
- 1993-03-03 US US07/965,246 patent/US5565203A/en not_active Expired - Lifetime
-
1999
- 1999-10-13 GR GR990402616T patent/GR3031520T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2135406T3 (es) | 1999-11-01 |
CA2086831C (en) | 1999-03-16 |
WO1992019267A1 (en) | 1992-11-12 |
AU1745692A (en) | 1992-12-21 |
CA2086831A1 (en) | 1992-11-09 |
JPH06500128A (ja) | 1994-01-06 |
ATE182791T1 (de) | 1999-08-15 |
DK0538437T3 (da) | 2000-02-07 |
AU655823B2 (en) | 1995-01-12 |
US5565203A (en) | 1996-10-15 |
EP0538437B1 (de) | 1999-08-04 |
EP0538437A1 (de) | 1993-04-28 |
GR3031520T3 (en) | 2000-01-31 |
DE69229703T2 (de) | 2000-04-27 |
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