DE69230140D1 - Antivirale nucleosidkombination - Google Patents

Antivirale nucleosidkombination

Info

Publication number
DE69230140D1
DE69230140D1 DE69230140T DE69230140T DE69230140D1 DE 69230140 D1 DE69230140 D1 DE 69230140D1 DE 69230140 T DE69230140 T DE 69230140T DE 69230140 T DE69230140 T DE 69230140T DE 69230140 D1 DE69230140 D1 DE 69230140D1
Authority
DE
Germany
Prior art keywords
antiviral nucleoside
combinations
combination
nucleoside combination
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69230140T
Other languages
English (en)
Other versions
DE69230140T2 (de
Inventor
George Painter
Phillip Furman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of DE69230140D1 publication Critical patent/DE69230140D1/de
Publication of DE69230140T2 publication Critical patent/DE69230140T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69230140T 1991-03-06 1992-03-05 Antivirale nucleosidkombination Expired - Lifetime DE69230140T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919104740A GB9104740D0 (en) 1991-03-06 1991-03-06 Antiviral nucleoside combination
PCT/GB1992/000389 WO1992015309A1 (en) 1991-03-06 1992-03-05 Antiviral nucleoside combination

Publications (2)

Publication Number Publication Date
DE69230140D1 true DE69230140D1 (de) 1999-11-18
DE69230140T2 DE69230140T2 (de) 2000-04-06

Family

ID=10691101

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69230140T Expired - Lifetime DE69230140T2 (de) 1991-03-06 1992-03-05 Antivirale nucleosidkombination

Country Status (26)

Country Link
US (2) US5234913A (de)
EP (1) EP0574457B1 (de)
JP (1) JP3442773B2 (de)
KR (1) KR100225986B1 (de)
AT (1) ATE185483T1 (de)
AU (1) AU668860B2 (de)
CA (1) CA2105487C (de)
CZ (1) CZ283185B6 (de)
DE (1) DE69230140T2 (de)
DK (1) DK0574457T3 (de)
ES (1) ES2138969T3 (de)
GB (1) GB9104740D0 (de)
GR (1) GR3032299T3 (de)
HK (1) HK1004189A1 (de)
HU (1) HU219492B (de)
IE (1) IE920702A1 (de)
IL (1) IL101145A (de)
MY (1) MY108638A (de)
NZ (1) NZ241842A (de)
PT (1) PT100199B (de)
RU (1) RU2110993C1 (de)
SK (1) SK279767B6 (de)
TW (1) TW199861B (de)
UA (1) UA29429C2 (de)
WO (1) WO1992015309A1 (de)
ZA (1) ZA921660B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903224B2 (en) 1988-04-11 2005-06-07 Biochem Pharma Inc. Substituted 1,3-oxathiolanes
SE464168B (sv) * 1989-07-19 1991-03-18 Bo Fredrik Oeberg Antiviral komposition bestaaende av en 3'-fluoro-2',3'-dideoxynukleosidfoerening och en 2',3'-dideoxynukleosidfoerening (exempelvis azt)
US6703396B1 (en) 1990-02-01 2004-03-09 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5925643A (en) * 1990-12-05 1999-07-20 Emory University Enantiomerically pure β-D-dioxolane-nucleosides
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
US6812233B1 (en) * 1991-03-06 2004-11-02 Emory University Therapeutic nucleosides
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
SK279262B6 (sk) * 1991-05-16 1998-08-05 Glaxo Group Limited Protivírusová zmes, farmaceutický prostriedok s je
GB9116601D0 (en) * 1991-08-01 1991-09-18 Iaf Biochem Int 1,3-oxathiolane nucleoside analogues
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
AU2119695A (en) * 1994-03-16 1995-10-03 Tanox Biosystems, Inc. Synergistic inhibition of hiv-1 infection using a nucleoside reverse transcriptase inhibitor and anti-hiv-1 antibodies
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
MY115461A (en) * 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
PT831852E (pt) 1995-06-07 2007-02-28 Uab Research Foundation Nucleósidos com actividade anti-vírus da hepatite b
BR9709939A (pt) * 1996-06-25 1999-08-10 Glaxo Group Ltd Combinação formulação farmacêutica processo de tratamento de uma infecção por hiv em um animal infectado usos de éster tetraidro-3-furanila do ácido 3s[3r*(1r*,2s*)]-[-3-[[4-amino-fenil)sulfonil](2-metilprop ril)-amino]-2-hidroxi-1-fenilmetil)propil]-carbâmico de zidovudina e de (2r,cis)-4-amino-1-(2-hidroximetil-1,3-oxatiolan-5-il)-(1h)-pirimidin-2-ona e pacote para paciente
KR20000022225A (ko) * 1996-06-25 2000-04-25 그레이엄 브레레톤;레슬리 에드워즈 Hiv 치료에 사용하기 위한 vx478, 지도부딘 및(또는)1592u89를 포함하는 배합물
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
EA005097B1 (ru) * 1997-03-19 2004-10-28 Эмори Юниверсити Синтез 1,3-оксаселеноланнуклеозидов, обладающих активностью против вируса иммунодефицита человека и против вируса гепатита-b
CA2285577A1 (en) 1997-04-07 1998-10-15 Triangle Pharmaceuticals, Inc. Compositions containing mkc-442 in combination with other antiviral agents
US6040434A (en) * 1997-12-01 2000-03-21 Inaba; Tadanobu Aldehyde oxidase inhibitors for treatment of aids
AU4716299A (en) * 1998-06-24 2000-01-10 Emory University Use of 3'-azido-2',3'-dideoxyuridine in combination with further anti-hiv drugs for the manufacture of a medicament for the treatment of hiv
CN1141305C (zh) 1998-08-12 2004-03-10 三角药物公司 生产1,3-氧硫戊环核苷的方法
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
DK1382343T3 (da) 1998-11-02 2010-04-26 Gilead Sciences Inc Kombinationsterapi til behandling af hepatitis B-virus
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
EP1903041B1 (de) 2001-03-01 2015-02-18 AbbVie Inc. Polymorphe und andere kristalline Formen von Cis-FTC
UA93354C2 (ru) * 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT390000B (de) * 1985-03-16 1990-02-26 Wellcome Found Verwendung von 3'-azido-3'-desoxythymidin oder eines pharmazeutisch annehmbaren derivats hievon zur herstellung von medikamenten
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US4874751A (en) * 1985-03-16 1989-10-17 Burroughs Wellcome Co. Antibacterial treatment
HU196607B (en) * 1985-05-15 1988-12-28 Wellcome Found Process for producing dideoxy-nucleosides and pharmaceutics comprising such compounds
NZ222695A (en) * 1986-11-29 1990-03-27 Ueno Seiyaku Oyo Kenkyujo Kk Synergistic antiviral compositions
US5159067A (en) * 1987-01-28 1992-10-27 University Of Georgia Research Foundation Inc. 5'-Diphosphohexose nucleoside pharmaceutical compositions
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
US5041449A (en) * 1988-04-11 1991-08-20 Iaf Biochem International, Inc. 4-(nucleoside base)-substituted-1,3-dioxolanes useful for treatment of retroviral infections
NZ228645A (en) * 1988-04-11 1991-09-25 Iaf Biochem Int 1,3-dioxolane derivatives substituted in the 5th position by a purine or pyrimidine radical; treatment of viral infections
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
CA2055433A1 (en) * 1989-05-15 1990-11-16 Jay H. Hoofnagle Method of treatment of hepatitis
US5071983A (en) * 1989-10-06 1991-12-10 Burroughs Wellcome Co. Therapeutic nucleosides
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
IT1249019B (it) * 1990-06-28 1995-02-11 Lamberti S P A L Emulsione acquosa di resine filmogene per la finitura di pelli, cuoio e croste di pelle e relativo procedimento di applicazione
DK0560794T3 (da) * 1990-11-13 1996-12-23 Iaf Biochem Int Substituerede 1,3-oxathiolaner med antivirale egenskaber
IL100502A (en) * 1991-01-03 1995-12-08 Iaf Biochem Int PHARMACEUTICAL PREPARATIONS CONTAINING CIS-4-AMINO-1-) 2-HYDROXIMETHIL-1,3-OXETYOLEN-5-IL (-
GB9104740D0 (en) * 1991-03-06 1991-04-17 Wellcome Found Antiviral nucleoside combination
SK279262B6 (sk) * 1991-05-16 1998-08-05 Glaxo Group Limited Protivírusová zmes, farmaceutický prostriedok s je

Also Published As

Publication number Publication date
CA2105487C (en) 2002-09-24
HK1004189A1 (en) 1998-11-20
KR100225986B1 (ko) 1999-10-15
ZA921660B (en) 1993-09-06
US5234913A (en) 1993-08-10
PT100199B (pt) 1999-06-30
IL101145A0 (en) 1992-11-15
DE69230140T2 (de) 2000-04-06
NZ241842A (en) 1994-08-26
EP0574457B1 (de) 1999-10-13
TW199861B (de) 1993-02-11
EP0574457A1 (de) 1993-12-22
AU668860B2 (en) 1996-05-23
RU2110993C1 (ru) 1998-05-20
SK279767B6 (sk) 1999-03-12
HU219492B (hu) 2001-04-28
UA29429C2 (uk) 2000-11-15
JP3442773B2 (ja) 2003-09-02
AU1351292A (en) 1992-10-06
DK0574457T3 (da) 2000-04-17
PT100199A (pt) 1993-07-30
CZ183693A3 (en) 1994-06-15
IL101145A (en) 1996-08-04
WO1992015309A1 (en) 1992-09-17
CZ283185B6 (cs) 1998-01-14
CA2105487A1 (en) 1992-09-07
SK95193A3 (en) 1994-01-12
IE920702A1 (en) 1992-09-09
ATE185483T1 (de) 1999-10-15
GR3032299T3 (en) 2000-04-27
GB9104740D0 (en) 1991-04-17
HU9302496D0 (en) 1993-11-29
ES2138969T3 (es) 2000-02-01
MY108638A (en) 1996-10-31
JPH06506199A (ja) 1994-07-14
US6107288A (en) 2000-08-22
HUT72460A (en) 1996-04-29

Similar Documents

Publication Publication Date Title
DE69230140T2 (de) Antivirale nucleosidkombination
ES2186667T3 (es) Analogos de nucleosidos de 1,3-oxatiolano.
RU93045710A (ru) Противовирусная нуклеозидная композиция, способ ее получения и способ лечения
DK224286A (da) 2',3'-dideoxy-nucleosider
ITBO910476A0 (it) -formulazioni farmeceutiche vaginali contenenti rifaximin e loro uso nel trattamento delle infezioni vaginali.
ES2083668T5 (es) Combinaciones antiviricas que contienen analogos de nucleosido.
MY107843A (en) Anti-viral compounds.
TR199903053T2 (xx) Benzimidazol t�revleri.
ATE100098T1 (de) Nukleoside, ihre herstellung und pharmazeutische zusammenstellungen.
IT1224594B (it) Impiego in terapeutica di derivati del 4h-benzo-4,5-cicloepta-1,2-bqti ofene
GR3024699T3 (en) Use of dideoxy nucleoside analogues in the treatment of viral infections.
GB8822546D0 (en) Antiviral combinations
NO970178D0 (no) Terpenoidderivater (sarcodictyiner) som er nyttige som antitumormidler
ES2101747T3 (es) Penciclovir y famciclovir y derivados de guanina relacionados para el tratamiento de infecciones por vih-1.
NO921563L (no) Terapeutisk aktive aminopyrimidinderivater, fremgangsmaatefor deres fremstilling og anvendelse derav
ATE57526T1 (de) P-acylaminobenzamide.
MX9303985A (es) Nucleosidos terapeuticos.
NO894658D0 (no) Antivirale forbindelser.
IT9048026A0 (it) Preparato farmaceutico e/o cosmetico.
MX9203485A (es) Derivados de tieno sulfonamida, composiciones farmaceuticas y uso.
ITRM920930A0 (it) Impiego del glutatione per la preparazione di composizioni farmaceutiche ad attivita' antivirale.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition