DE69230372D1 - Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität - Google Patents
Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivitätInfo
- Publication number
- DE69230372D1 DE69230372D1 DE69230372T DE69230372T DE69230372D1 DE 69230372 D1 DE69230372 D1 DE 69230372D1 DE 69230372 T DE69230372 T DE 69230372T DE 69230372 T DE69230372 T DE 69230372T DE 69230372 D1 DE69230372 D1 DE 69230372D1
- Authority
- DE
- Germany
- Prior art keywords
- biological activity
- preparations
- polyoxypropylen
- polyoxyethylen
- copolymere
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
- C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G65/08—Saturated oxiranes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
- C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
- C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2618—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen
- C08G65/2621—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups
- C08G65/2624—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups containing aliphatic amine groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67328991A | 1991-03-19 | 1991-03-19 | |
US84787492A | 1992-03-13 | 1992-03-13 | |
PCT/US1992/002254 WO1992016484A1 (en) | 1991-03-19 | 1992-03-18 | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69230372D1 true DE69230372D1 (de) | 2000-01-05 |
DE69230372T2 DE69230372T2 (de) | 2000-06-15 |
Family
ID=27100911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69230372T Expired - Fee Related DE69230372T2 (de) | 1991-03-19 | 1992-03-18 | Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität |
Country Status (19)
Country | Link |
---|---|
US (7) | US5523492A (de) |
EP (1) | EP0576612B1 (de) |
JP (1) | JP2647556B2 (de) |
KR (1) | KR100224539B1 (de) |
CN (1) | CN1069741A (de) |
AT (1) | ATE187154T1 (de) |
AU (1) | AU662146B2 (de) |
CA (1) | CA2106474C (de) |
CZ (1) | CZ194693A3 (de) |
DE (1) | DE69230372T2 (de) |
DK (1) | DK0576612T3 (de) |
ES (1) | ES2140408T3 (de) |
GR (1) | GR3032726T3 (de) |
HU (1) | HUT67762A (de) |
IE (1) | IE920860A1 (de) |
IL (1) | IL101305A (de) |
NO (1) | NO307890B1 (de) |
SK (1) | SK100893A3 (de) |
WO (1) | WO1992016484A1 (de) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5674911A (en) * | 1987-02-20 | 1997-10-07 | Cytrx Corporation | Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use |
JP2647556B2 (ja) * | 1991-03-19 | 1997-08-27 | サイトアーレクス・コーポレーシヨン | 改良された生物学的活性を有するポリオキシプロピレン/ポリオキシエチレン共重合体類 |
USRE38558E1 (en) | 1991-03-19 | 2004-07-20 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
US6933286B2 (en) | 1991-03-19 | 2005-08-23 | R. Martin Emanuele | Therapeutic delivery compositions and methods of use thereof |
US7202225B1 (en) | 1993-10-15 | 2007-04-10 | Emanuele R Martin | Therapeutic delivery compositions and methods of use thereof |
ZA933926B (en) * | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
US6277410B1 (en) * | 1992-10-08 | 2001-08-21 | Supratek Pharma Inc. | Copolymer compositions for oral delivery |
US6093391A (en) * | 1992-10-08 | 2000-07-25 | Supratek Pharma, Inc. | Peptide copolymer compositions |
US6153193A (en) * | 1993-04-28 | 2000-11-28 | Supratek Pharma Inc. | Compositions for targeting biological agents |
DE69428521T2 (de) * | 1993-02-02 | 2002-05-23 | Xoma Technology Ltd | Arzneizusammensetzungen enthaltend ein bakterizides permeabilität erhöhendes protein und ein tensid |
KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
EP0723440B1 (de) * | 1993-10-15 | 2003-01-02 | Cytrx Corporation | Therapeutische abgabesysteme und verfahren für ihre verwendung |
US5932544A (en) * | 1994-05-31 | 1999-08-03 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) compositions |
EP1181937A3 (de) | 1994-08-09 | 2004-02-04 | Cytrx Corporation | Nukleinsäure enthaltender Impfstoff, Impfstoff-adjuvans |
US6353055B1 (en) | 1994-11-18 | 2002-03-05 | Supratek Pharma Inc. | Polynucleotide compositions |
US6221959B1 (en) | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
WO1998013069A2 (en) * | 1996-09-09 | 1998-04-02 | Supratek Pharma, Inc. | Fluorinated copolymeric pharmaceutical adjuncts |
US6942859B2 (en) | 1998-03-13 | 2005-09-13 | University Of Southern California | Red blood cells covalently bound with polymers |
US6312685B1 (en) | 1998-03-13 | 2001-11-06 | Timothy C. Fisher | Red blood cells covalently bound with two different polyethylene glycol derivatives |
WO2000021543A1 (en) * | 1998-10-09 | 2000-04-20 | Cytrx Corporation | Method and composition for treating ischemia and sickle cell anemia |
CA2376057A1 (en) * | 1999-06-08 | 2000-12-14 | La Jolla Pharmaceutical Company | Valency platform molecules comprising aminooxy groups |
US6951939B2 (en) | 2000-06-08 | 2005-10-04 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
US20070092526A1 (en) * | 2000-06-23 | 2007-04-26 | Evans Robert K | Polynucleotide vaccine adjuvants and formulations containing cationic surfactants, and methods of use |
US6761824B2 (en) | 2000-08-17 | 2004-07-13 | Reeve Lorraine E | Process for the fractionation of polymers |
US20040266983A1 (en) * | 2000-08-17 | 2004-12-30 | Reeve Lorraine E | Purified polyoxyalkylene block copolymers |
WO2003079972A2 (en) | 2002-02-22 | 2003-10-02 | New River Parmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
CA2426582A1 (en) * | 2000-10-20 | 2002-08-08 | Valentis, Inc. | Gene delivery formulations and methods for treatment of ischemic conditions |
US20040009940A1 (en) * | 2000-10-20 | 2004-01-15 | Coleman Michael E. | Gene delivery formulations and methods for treatment of ischemic conditions |
US6492881B2 (en) * | 2001-01-31 | 2002-12-10 | Compaq Information Technologies Group, L.P. | Single to differential logic level interface for computer systems |
NZ529526A (en) * | 2001-04-24 | 2006-06-30 | Purdue Research Foundation | Method and compositions for treating mammalian nerve tissue injuries |
WO2004010941A2 (en) * | 2002-07-29 | 2004-02-05 | Transform Pharmaceuticals, Inc. | Aqueous 2,6-diisopropylphenol pharmaceutical compositions |
US6966990B2 (en) | 2002-10-11 | 2005-11-22 | Ferro Corporation | Composite particles and method for preparing |
JP4917263B2 (ja) * | 2002-12-23 | 2012-04-18 | バイカル インコーポレイテッド | 核酸/ブロックコポリマー/陽イオン性界面活性剤複合体を凍結乾燥する方法 |
EP1581201A4 (de) * | 2002-12-23 | 2011-03-30 | Vical Inc | Verfahren zur herstellung steriler arzneimittel auf polynukleotidbasis |
US7083748B2 (en) * | 2003-02-07 | 2006-08-01 | Ferro Corporation | Method and apparatus for continuous particle production using supercritical fluid |
JP4909071B2 (ja) * | 2003-03-24 | 2012-04-04 | プルーローメッド, インコーポレイテッド | 逆感熱性ポリマーを使用する一時的な塞栓形成 |
US20060008531A1 (en) * | 2003-05-08 | 2006-01-12 | Ferro Corporation | Method for producing solid-lipid composite drug particles |
EP1663261A2 (de) * | 2003-09-05 | 2006-06-07 | Mannarsamy Balasubramanian | Gereinigte polyoxypropylen/polyoxyethylen-copolymere und herstellungsverfahren dafür |
JP4898447B2 (ja) | 2003-10-14 | 2012-03-14 | プルーロームド インコーポレイテッド | 結石破砕術の際の腎結石破片の閉じ込め |
WO2005046438A2 (en) | 2003-11-06 | 2005-05-26 | Pluromed, Inc. | Internal clamp for surgical procedures |
JP4521547B2 (ja) * | 2004-04-15 | 2010-08-11 | 株式会社サンメディカル技術研究所 | 血液ポンプの流量推定装置 |
US20060134221A1 (en) * | 2004-12-03 | 2006-06-22 | Vical Incorporated | Methods for producing block copolymer/amphiphilic particles |
AU2006216420B2 (en) * | 2005-02-25 | 2010-07-15 | The Regents Of The University Of Michigan | Compositions and methods for treating and preventing cardiomyopathy and heart disease |
EP1868652A2 (de) | 2005-04-05 | 2007-12-26 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Verfahren zur abschirmung von funktionalen stellen oder epitopen auf proteinen |
EP2857041B9 (de) | 2005-05-02 | 2018-02-14 | Genzyme Corporation | Nierensteintherapie ohne Lithotripsie |
US8815557B2 (en) * | 2005-07-08 | 2014-08-26 | University Of Chicago | Compositions and methods for refolding of denatured proteins |
WO2008018892A2 (en) * | 2005-12-22 | 2008-02-14 | Pluromed, Inc. | Methods and kits for treating lacerations and puncture wounds using inverse thermosensitive polymers |
WO2008016640A2 (en) * | 2006-08-01 | 2008-02-07 | Phrixus Pharmaceuticals, Incorporated | Use of poloxamer for the prevention and/or treatment of heart failure |
WO2008033728A2 (en) | 2006-09-11 | 2008-03-20 | Pluromed, Inc. | Atraumatic occlusion balloons and skirts, and methods of use thereof |
US20080181952A1 (en) * | 2006-12-11 | 2008-07-31 | Pluromed, Inc. | Perfusive Organ Hemostasis |
BRPI0807558A2 (pt) * | 2007-02-22 | 2014-07-01 | Pluromed Inc | Uso de polímeros termosensíveis reversos para controlar o fluxo de fluido biológico subsequente a um procedimento médico |
MX2009010778A (es) * | 2007-04-05 | 2010-01-29 | Phrixus Pharmaceuticals Inc | Composiciones y metodos para el tratamiento de insuficiencia cardiaca. |
EP2185162A4 (de) * | 2007-08-10 | 2012-04-25 | Synthrx Inc | Polymertherapie zur behandlung chronischer mikrovaskulärer erkankungen |
DK2222697T3 (da) | 2007-11-01 | 2013-03-11 | Perseid Therapeutics Llc | Immunsuppressive polypeptider og nukleinsyrer |
EP2219546B1 (de) | 2007-11-29 | 2017-02-01 | Genzyme Corporation | Endoskopische schleimhaut-resektionierung mit gereinigten inversen wärmeempfindlichen polymeren |
ES2594302T3 (es) | 2007-12-17 | 2016-12-19 | The Regents Of The University Of Michigan | Composiciones y procedimientos de tratamiento y prevención de deficiencias de músculo esquelético |
EP2350274B1 (de) | 2008-10-21 | 2019-01-23 | The General Hospital Corporation | Zelltransplantation |
DE102008043343A1 (de) * | 2008-10-31 | 2010-05-06 | Evonik Goldschmidt Gmbh | Silikonpolyetherblock-Copolymere mit definierter Polydispersität im Polyoxyalkylenteil und deren Verwendung als Stabilisatoren zur Herstellung von Polyurethanschäumen |
WO2010072769A1 (de) | 2008-12-23 | 2010-07-01 | Basf Se | Verfahren zur herstellung von polyether-blockcopolymeren |
EP3508197A1 (de) | 2009-10-21 | 2019-07-10 | Otonomy, Inc. | Modulation der geltemperatur poloxamerhaltiger formulierungen |
GB201008902D0 (en) * | 2010-05-27 | 2010-07-14 | Imp Innovations Ltd | Membrane enhanced polymer sythesis |
EP2601299B1 (de) | 2010-08-06 | 2019-04-24 | The General Hospital Corporation D/B/A Massachusetts General Hospital | System und vorrichtung zur behandlung von zellen |
AU2011329088B2 (en) | 2010-11-15 | 2016-02-25 | Liferaft Biosciences, Inc. | Methods for enhancing oxygenation of jeopardized tissue |
CN103732233B (zh) | 2011-03-18 | 2016-08-10 | 贝克斯特国际公司 | 包含葡萄糖聚合物的腹膜透析溶液 |
FR2977495B1 (fr) * | 2011-07-07 | 2014-03-07 | Sanofi Sa | Composition pharmaceutique et forme galenique solide a haute teneur en dronedarone et son procede de preparation |
US9662345B2 (en) | 2013-06-14 | 2017-05-30 | Professional Compounding Centers Of America | Antibiotic composition for inhalation and irrigation |
CA2927361A1 (en) | 2013-10-16 | 2015-04-23 | Mast Therapeutics, Inc. | Diuretic induced alterations of plasma volume |
JP6202471B2 (ja) | 2013-10-31 | 2017-09-27 | 日油株式会社 | 医用ポリオキシプロピレン重合体の製造方法および医用ポリオキシプロピレン/ポリオキシエチレンブロック共重合体の製造方法 |
US20160000823A1 (en) * | 2014-07-07 | 2016-01-07 | Mast Therapeutics, Inc. | Methods and compositions for improving hemostasis |
US9757411B2 (en) | 2014-07-07 | 2017-09-12 | Aires Pharmaceuticals, Inc. | Poloxamer therapy for heart failure |
WO2016007542A1 (en) | 2014-07-07 | 2016-01-14 | Mast Therapeutics, Inc. | Poloxamer therapy for heart failure |
US9403941B2 (en) | 2014-07-07 | 2016-08-02 | Mast Therapeutics, Inc. | Poloxamer composition free of long circulating material and methods for production and uses thereof |
JP6900378B2 (ja) * | 2015-12-22 | 2021-07-07 | ビーエイエスエフ・ソシエタス・エウロパエアBasf Se | ポリエーテルブロックコポリマーの精製方法 |
EP3580261A1 (de) | 2017-02-09 | 2019-12-18 | Basf Se | Verfahren zur reinigung von polyether-blockcopolymeren |
KR102544922B1 (ko) * | 2017-12-21 | 2023-06-16 | 시그마-알드리치 컴퍼니., 엘엘씨 | 폴록사머 조성물 및 이의 제조 및 사용 방법 |
AU2019250128A1 (en) | 2018-10-15 | 2020-04-30 | Avent Inc. | Compositions, systems, kits, and methods for neural ablation |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2979528A (en) * | 1953-10-19 | 1961-04-11 | Wyandotte Chemicals Corp | Nitrogen-containing polyoxyalkylene detergent compositions |
US2674619A (en) * | 1953-10-19 | 1954-04-06 | Wyandotte Chemicals Corp | Polyoxyalkylene compounds |
US3022335A (en) * | 1955-03-30 | 1962-02-20 | Wyandotte Chemicals Corp | Surface active polyoxyalkylene compounds having a plurality of heteric polyoxypropylene-polyoxyethylene chains |
US2854378A (en) * | 1955-12-08 | 1958-09-30 | Bristol Lab Inc | Tetracycline suppository |
US3036118A (en) * | 1957-09-11 | 1962-05-22 | Wyandotte Chemicals Corp | Mixtures of novel conjugated polyoxyethylene-polyoxypropylene compounds |
US3089818A (en) * | 1960-06-02 | 1963-05-14 | Baxter Laboratories Inc | Water dispersible antibiotics |
US3228834A (en) * | 1962-06-08 | 1966-01-11 | Hoffmann La Roche | Pharmaceutical diluent compositions |
US3140232A (en) * | 1962-12-19 | 1964-07-07 | Pfizer & Co C | Color stabilization of tetracycline compositions with polypropylene glycols |
US3391196A (en) * | 1965-08-16 | 1968-07-02 | Wyandotte Chemicals Corp | High equivalent weight hydroxy-terminated ethylene oxide-butylene oxide polyether polyols |
US3740421A (en) * | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
US3450502A (en) * | 1967-09-25 | 1969-06-17 | Wyandotte Chemicals Corp | Method of operating heart-lung apparatus |
US3641240A (en) * | 1968-09-27 | 1972-02-08 | Wyandotte Chemicals Corp | Method for the treatment of an embolus or thrombus |
US3867533A (en) * | 1968-12-20 | 1975-02-18 | Basf Wyandotte Corp | Preparation of aqueous gel compositions containing a water-insoluble organic ingredient |
US3577522A (en) * | 1969-10-10 | 1971-05-04 | Wyandotte Chemicals Corp | Methods for the treatment of shock with ethylene oxide-polypropylene glycol condensates as blood plasma substitutes |
US3590125A (en) * | 1969-10-10 | 1971-06-29 | Wyandotte Chemicals Corp | Physiological salt solutions of ethylene oxide-polypropylene glycol condensation products as blood plasma substitutes |
US3980772A (en) * | 1969-12-02 | 1976-09-14 | Baxter Laboratories, Inc. | Methods of dissolving blood clots and the like with streptokinase chemically bonded to a carbohydrate matrix |
CA959759A (en) * | 1970-01-15 | 1974-12-24 | John J. Miskel | Method for absorption of drugs |
US3867521A (en) * | 1970-08-26 | 1975-02-18 | Scherer Corp R P | Method for absorption of drugs |
US4073886A (en) * | 1973-01-30 | 1978-02-14 | Baxter Travenol Laboratories, Inc. | Blood fractionation process using block copolymers of ethylene oxide and polyoxypropylene |
US3956259A (en) * | 1973-01-30 | 1976-05-11 | Baxter Laboratories, Inc. | Fractionation of blood using block copolymer of ethylene oxide and polyoxypropylene polymer to recover fraction suitable for organ perfusate |
US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US3997458A (en) * | 1974-04-12 | 1976-12-14 | Deknatel, Incorporated | Method of cleansing contaminated wounds and surgical scrub solutions for same |
US4104455A (en) * | 1975-03-25 | 1978-08-01 | Toyo Soda Manufacturing Co., Ltd. | Polymerization of monomer |
US4100271A (en) * | 1976-02-26 | 1978-07-11 | Cooper Laboratories, Inc. | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
US4195167A (en) | 1976-05-28 | 1980-03-25 | Union Carbide Corporation | Gradient polymers of two or more cyclic, organic, ring-opening, addition polymerizable monomers and methods for making same |
JPS545094A (en) | 1977-06-09 | 1979-01-16 | Tokyo Tanabe Co | Production of pharmaceutical urokinase from contamination free human urine |
DE2732929A1 (de) * | 1977-07-21 | 1979-02-01 | Bayer Ag | Polyaether, verfahren zu ihrer herstellung sowie ihre verwendung als lipidabsorptionshemmer |
DE2961374D1 (en) * | 1978-01-27 | 1982-01-28 | Bp Chem Int Ltd | A method for increasing the selectivity to acetic acid in the production of a mixture of c1 to c3 monocarboxylic acids by oxidation of paraffinic hydrocarbons |
DE2808865A1 (de) * | 1978-03-02 | 1979-09-13 | Hoechst Ag | Mikrobiozide mittel auf der basis von alkyl-di-guanidinium-salzen |
US4275244A (en) * | 1978-05-11 | 1981-06-23 | Basf Wyandotte Corporation | Linear polyalkylene ether glycols of high molecular weight |
JPS5533194A (en) | 1978-08-07 | 1980-03-08 | Scholz D Thomas | Stringgfastener device including tremolant |
US4305922A (en) * | 1978-10-04 | 1981-12-15 | University Patents, Inc. | Labeling proteins with 99m-Tc by ligand exchange |
US4186253A (en) * | 1978-10-10 | 1980-01-29 | The Green Cross Corporation | Perfusate for preserving organ to be transplanted and preserving method |
DE2850058A1 (de) * | 1978-11-18 | 1980-05-29 | Bayer Ag | Polyaether-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
FR2454409A1 (fr) * | 1979-04-18 | 1980-11-14 | Sovam | Vehicule tracteur notamment pour avions gros porteurs |
FI803077A (fi) * | 1979-10-12 | 1981-04-13 | Ciba Geigy Ag | Foerfarande foer framstaellning av myramylpeptider |
US4409209A (en) * | 1979-10-12 | 1983-10-11 | Ciba-Geigy Corporation | Novel phosphorylmuramyl peptides and processes for the manufacture thereof |
US4575484A (en) * | 1980-05-05 | 1986-03-11 | Montefiore Medical Center, Inc. | Binding assay for the detection of mycobacteria |
US4410660A (en) * | 1980-05-05 | 1983-10-18 | Montefiore Medical Center | Binding assay for the detection of mycobacteria |
US4489158A (en) * | 1980-05-05 | 1984-12-18 | Montefiore Hospital And Medical Center, Inc. | Binding assay for the detection of mycobacteria |
JPS578223A (en) * | 1980-06-19 | 1982-01-16 | Mitsui Petrochem Ind Ltd | Production of alkylene oxide block copolymer |
US4378347A (en) * | 1980-06-30 | 1983-03-29 | Franco Wayne P | Composition for treating the heart for myocardial infarction |
US4376118A (en) * | 1980-10-06 | 1983-03-08 | Miles Laboratories, Inc. | Stable nonaqueous solution of tetracycline salt |
GR78246B (de) * | 1981-01-23 | 1984-09-26 | Ciba Geigy Ag | |
US4395393A (en) * | 1981-08-10 | 1983-07-26 | Basf Wyandotte Corporation | Artificial blood emulsifiers |
US4407790A (en) * | 1981-09-25 | 1983-10-04 | Economics Laboratory, Inc. | Method of controlling bloat using nonionic surfactants |
US4609546A (en) * | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
DE3234084A1 (de) * | 1982-09-14 | 1984-03-15 | B. Braun Melsungen Ag, 3508 Melsungen | Pharmazeutische zubereitungen zur behandlung von unerwuenschten verwachsungen sowie deren verwendung |
SU1183112A1 (ru) * | 1983-08-04 | 1985-10-07 | Научно-Исследовательский Институт Экспериментальной И Клинической Терапии Министерства Здравоохранения Гсср | Способ лечени острой ишемии миокарда |
US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
US4600652A (en) * | 1985-04-01 | 1986-07-15 | Warner-Lambert Company | Permanently bonded antithrombogenic polyurethane surface |
US5183687A (en) * | 1985-06-18 | 1993-02-02 | Emory University | Method of treating poultry for coccidiosis |
US5114708A (en) * | 1985-06-18 | 1992-05-19 | Emory University | Method for stimulating growth in animals |
US4806352A (en) * | 1986-04-15 | 1989-02-21 | Ribi Immunochem Research Inc. | Immunological lipid emulsion adjuvant |
US4803070A (en) * | 1986-04-15 | 1989-02-07 | Ribi Immunochem Research Inc. | Immunological emulsion adjuvants for polysaccharide vaccines |
US5017370A (en) * | 1986-05-15 | 1991-05-21 | Emory University | Improved method of performing angioplasty procedures |
US5047236A (en) * | 1986-05-15 | 1991-09-10 | Emory University | Method of treating stroke |
JPH0610139B2 (ja) * | 1986-05-15 | 1994-02-09 | エモリ ユニバーシティ | 繊維素溶解性合成物混合物及び血管内の血餅溶解用薬剤 |
US4897263A (en) * | 1986-05-15 | 1990-01-30 | Emory University | Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids |
US5089260A (en) * | 1986-05-15 | 1992-02-18 | Emory University | Method of treating ischemic tissue |
US4879109A (en) * | 1986-05-15 | 1989-11-07 | Emory University | Method for treating burns |
US5080894A (en) * | 1986-05-15 | 1992-01-14 | Emory University | Method and composition for reducing tissue damage |
US5028599A (en) * | 1986-05-15 | 1991-07-02 | Emory University | Method of treating mycardial damage |
US4837014A (en) * | 1986-05-15 | 1989-06-06 | Emory University | An improved method of treating sickle cell anemia |
US5064643A (en) * | 1986-05-15 | 1991-11-12 | Emory University | Method for treating sickle cell disease |
US5030448A (en) * | 1986-05-15 | 1991-07-09 | Emory University | Method of delivering drugs to damaged or diseased tissue |
US5032394A (en) * | 1986-05-15 | 1991-07-16 | Emory University | Method of treating burns |
US5198211A (en) * | 1986-05-15 | 1993-03-30 | Emory University | Method of treating myocardial damage |
US4937070A (en) * | 1986-05-15 | 1990-06-26 | Emory University | Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids |
WO1987006831A1 (en) * | 1986-05-15 | 1987-11-19 | Emory University | Composition and method for treating a thrombus and embolus |
US4801452A (en) * | 1986-05-15 | 1989-01-31 | Hunter Robert L | Fibrinolytic composition |
US5250294A (en) * | 1986-05-15 | 1993-10-05 | Emory University | Improved perfusion medium for transplantation of organs |
US5041288A (en) * | 1986-05-15 | 1991-08-20 | Emory University | Method of treating tissue damaged by reperfusion injury |
US5071649A (en) * | 1986-05-15 | 1991-12-10 | Emory University | Method of preventing blockage in catheters |
US4997644A (en) * | 1986-05-15 | 1991-03-05 | Emory University | Method of treating adult respiratory distress syndrome |
US5039520A (en) * | 1986-05-15 | 1991-08-13 | Emory University | Plasma extender |
US5078995A (en) * | 1986-05-15 | 1992-01-07 | Emory University | Fibrionolytic composition |
US4873083A (en) * | 1986-05-15 | 1989-10-10 | Emory University | Fibrinolytic composition |
JP2527942B2 (ja) * | 1986-09-18 | 1996-08-28 | ティーディーケイ株式会社 | 磁気記録媒体 |
US5554372A (en) | 1986-09-22 | 1996-09-10 | Emory University | Methods and vaccines comprising surface-active copolymers |
US4764567A (en) | 1986-11-20 | 1988-08-16 | Basf Corporation | Process for the preparation of polyoxyalkylene block polyethers having enhanced properties |
AU1396588A (en) * | 1987-02-20 | 1988-09-14 | Emory University | Antiinfective compounds and method of use |
US5811088A (en) | 1987-02-20 | 1998-09-22 | Emory University | Antiinfective compounds and methods of use |
JPH07109520B2 (ja) | 1987-02-24 | 1995-11-22 | 株式会社リコー | 電子写真用感光体 |
US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
DE4014923A1 (de) * | 1990-05-10 | 1991-11-14 | Basf Ag | Verfahren zur herstellung von urethan- oder urethan- und isocyanuratgruppen enthaltenden hartschaumstoffen nach dem polyisocyanat-polyadditionsverfahren und die hierfuer geeigneten polyoxyalkylen-polyole |
JP2647556B2 (ja) * | 1991-03-19 | 1997-08-27 | サイトアーレクス・コーポレーシヨン | 改良された生物学的活性を有するポリオキシプロピレン/ポリオキシエチレン共重合体類 |
US5294365A (en) * | 1991-12-12 | 1994-03-15 | Basf Corporation | Hydroxypolyethers as low-foam surfactants |
US5371253A (en) * | 1993-12-14 | 1994-12-06 | Arco Chemical Technology, L.P. | Process for producing esterified alkoxylated monoglycerides and diglycerides |
-
1992
- 1992-03-18 JP JP4509970A patent/JP2647556B2/ja not_active Expired - Fee Related
- 1992-03-18 AT AT92910791T patent/ATE187154T1/de not_active IP Right Cessation
- 1992-03-18 HU HU9302628A patent/HUT67762A/hu unknown
- 1992-03-18 CN CN92102964A patent/CN1069741A/zh active Pending
- 1992-03-18 CA CA002106474A patent/CA2106474C/en not_active Expired - Fee Related
- 1992-03-18 IE IE086092A patent/IE920860A1/en not_active IP Right Cessation
- 1992-03-18 KR KR1019930702810A patent/KR100224539B1/ko not_active IP Right Cessation
- 1992-03-18 AU AU17730/92A patent/AU662146B2/en not_active Ceased
- 1992-03-18 EP EP92910791A patent/EP0576612B1/de not_active Expired - Lifetime
- 1992-03-18 DK DK92910791T patent/DK0576612T3/da active
- 1992-03-18 ES ES92910791T patent/ES2140408T3/es not_active Expired - Lifetime
- 1992-03-18 DE DE69230372T patent/DE69230372T2/de not_active Expired - Fee Related
- 1992-03-18 WO PCT/US1992/002254 patent/WO1992016484A1/en active IP Right Grant
- 1992-03-18 CZ CS931946A patent/CZ194693A3/cs unknown
- 1992-03-18 SK SK1008-93A patent/SK100893A3/sk unknown
- 1992-03-19 IL IL10130592A patent/IL101305A/en not_active IP Right Cessation
-
1993
- 1993-07-02 US US08/087,136 patent/US5523492A/en not_active Ceased
- 1993-09-17 NO NO933337A patent/NO307890B1/no unknown
-
1996
- 1996-06-03 US US08/657,161 patent/US5691387A/en not_active Ceased
-
1997
- 1997-07-08 US US08/889,342 patent/US5990241A/en not_active Expired - Fee Related
-
1998
- 1998-06-02 US US09/089,043 patent/USRE36665E/en not_active Expired - Lifetime
-
1999
- 1999-08-05 US US09/368,855 patent/US6359014B1/en not_active Expired - Fee Related
- 1999-11-19 US US09/444,417 patent/USRE37285E1/en not_active Expired - Fee Related
-
2000
- 2000-02-23 GR GR20000400425T patent/GR3032726T3/el not_active IP Right Cessation
-
2001
- 2001-12-14 US US10/017,223 patent/US6747064B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69230372D1 (de) | Polyoxypropylen/polyoxyethylen copolymere mit verbesserter biologischer aktivität | |
DE69024965T2 (de) | Dehydrodidemnin b | |
DK0611522T3 (da) | Synergistiske mikrobicide sammensætninger | |
ATE189263T1 (de) | Auswahl von effizient ziel-rns spaltenden ribozymen | |
PL308122A1 (en) | Viral vectors and their application in genic therapy | |
TR199801180T2 (xx) | Aneljestik etkiye sahip yeni bile�ikler. | |
DK480284A (da) | Sporstofmaerkede konjugater af metallothionein og maalsoegende, biologisk aktive molekyler | |
DE69331762T2 (de) | "heat shock"-proteine und behandlung von tumoren | |
TR28384A (tr) | Flüoroalifatik -ve karboksil- iceren terminal gruplarina sahip polisilokzanlar, bunlarin hazirlanmasi, ve lifli malzemelerin muamelesinde kullanimlari. | |
DE3884453D1 (de) | Homogene additionscopolymere von ethylen und cycloolefinmonomeren und deren herstellung. | |
ATE208208T1 (de) | Halogenid-enthaltende insulinzubereitungen | |
SE9101815D0 (sv) | Behandling av sjukdom foerbunden med hiv-infektioner | |
DK0445781T3 (da) | Anti-glaucomapræparater indeholdende 3-arylcarbonyl-1-aminoalkyl-1H-indol | |
ITMI912456A0 (it) | Ossa(tia)diazol- e triazol-oni(tioni)ad attivita' acarcida ed insetticida | |
RS49520B (sr) | Antimikrobno aktivne smeše | |
MY107501A (en) | Continuously magnetizing magnet. | |
FI960839A (fi) | Uusia tripeptidejä, jotka ovat käyttökelpoisia immuuni- ja CNS-terapiassa | |
GEP20012489B (en) | Use of Natural Human α-Interferon | |
DE3769497D1 (de) | Mittel zur bekaempfung von phytopathogenen mikroben. | |
ES2077614T3 (es) | Bacillus thuringiensis, variedad donegani, y preparacion o toxina obtenida de esta, dotado de actividad insecticida frente a cleopteros. | |
FR2370053A1 (fr) | Acides 7-acylamino-3-(1-(2,3-dihydroxypropyl)tetrazole-5-ylthiomethyl)-3-cepheme-4-carboxyliques et leur application en therapeutique | |
RU93056161A (ru) | Блок-сополимер полиоксипропилена и полиоксиэтилена, поверхностно-активный сополимер, способ получения нетоксичного поверхностно-активного сополимера, лекарственное средство | |
DK222988A (da) | Farmaceutiske praeparater indeholdende ornithin-decarboxylase-inhibitorer | |
BE905706A (fr) | Melanges herbicides et leur utilisation pour le traitement des cultures. | |
SU1536770A1 (ru) | Хлорид бензилгексаметилентетраммония, обладающий бактерицидной активностью в отношении сульфатвосстанавливающих бактерий и культур pseudomonas |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |