DE69230641T2 - Inhibitoren der stickstoffoxidsynthese zur potenzierung der wirkung von blutdruckwirksamen mitteln bei gewissen hypotonikern - Google Patents
Inhibitoren der stickstoffoxidsynthese zur potenzierung der wirkung von blutdruckwirksamen mitteln bei gewissen hypotonikernInfo
- Publication number
- DE69230641T2 DE69230641T2 DE69230641T DE69230641T DE69230641T2 DE 69230641 T2 DE69230641 T2 DE 69230641T2 DE 69230641 T DE69230641 T DE 69230641T DE 69230641 T DE69230641 T DE 69230641T DE 69230641 T2 DE69230641 T2 DE 69230641T2
- Authority
- DE
- Germany
- Prior art keywords
- alpha
- treatment
- arginine
- nitric oxide
- inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/085—Angiotensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/723,480 US5216025A (en) | 1989-09-13 | 1991-07-01 | Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients |
PCT/US1992/005570 WO1993000893A1 (en) | 1991-07-01 | 1992-07-01 | Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69230641D1 DE69230641D1 (de) | 2000-03-09 |
DE69230641T2 true DE69230641T2 (de) | 2000-06-15 |
Family
ID=24906450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69230641T Expired - Fee Related DE69230641T2 (de) | 1991-07-01 | 1992-07-01 | Inhibitoren der stickstoffoxidsynthese zur potenzierung der wirkung von blutdruckwirksamen mitteln bei gewissen hypotonikern |
Country Status (8)
Country | Link |
---|---|
US (1) | US5216025A (de) |
EP (1) | EP0592557B1 (de) |
JP (1) | JPH06508849A (de) |
AT (1) | ATE189386T1 (de) |
AU (1) | AU659664B2 (de) |
CA (1) | CA2111345A1 (de) |
DE (1) | DE69230641T2 (de) |
WO (1) | WO1993000893A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5395612A (en) * | 1990-03-27 | 1995-03-07 | Cornell Research Foundation, Inc. | Method for treating systemic hypotension caused by sepsis or cytokine using arginase in combination with an α1 adrenergic agonist |
US5286739A (en) * | 1991-09-27 | 1994-02-15 | Board Of Regents, University Of Texas System | Parenteral formulations for the inhibition of systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
US5374651A (en) * | 1991-09-27 | 1994-12-20 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of hypotension with arginine free essential and essential amino acids and arginine derivatives |
US5877176A (en) * | 1991-12-26 | 1999-03-02 | Cornell Research Foundation, Inc. | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis |
US5296466A (en) * | 1992-02-19 | 1994-03-22 | Board Of Regents, The University Of Texas System | Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein |
US5281627A (en) * | 1992-05-28 | 1994-01-25 | Cornell Research Foundation, Inc. | Substituted arginines and substituted homoarginines and use thereof |
AU5040493A (en) * | 1992-11-30 | 1994-06-09 | Transcend Therapeutics, Inc | Method for treating systemic inflammatory response syndrome |
US5585402A (en) * | 1992-12-23 | 1996-12-17 | Glaxo Wellcome Inc. | Nitric oxide synthase inhibitors |
US5436270A (en) * | 1993-04-07 | 1995-07-25 | National Science Council | Method for protecting against endotoxin-induced shock |
US5554638A (en) * | 1993-05-24 | 1996-09-10 | Duke University | Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders |
GB9312204D0 (en) * | 1993-06-14 | 1993-07-28 | Zeneca Ltd | Therapeutic composition |
US5424447A (en) * | 1993-07-07 | 1995-06-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Heme binding compounds and use thereof |
JPH09504028A (ja) * | 1993-10-21 | 1997-04-22 | ジー.ディー.サール アンド カンパニー | 酸化窒素シンターゼ抑制剤として有用なアミジノ誘導体 |
US5364881A (en) * | 1993-11-15 | 1994-11-15 | The Medical College Of Wisconsin Research Foundation, Inc. | S-alkyl-isothioureido-amino acids and use thereof |
US5502050A (en) * | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
US5665757A (en) * | 1994-07-13 | 1997-09-09 | Robert W. Dunn | Method for treating anxiety |
US5519020A (en) * | 1994-10-28 | 1996-05-21 | The University Of Akron | Polymeric wound healing accelerators |
US5545625A (en) * | 1994-12-12 | 1996-08-13 | The Medical College Of Wisconsin Research Foundation, Inc. | Preventing conversion of citrulline to argininosuccinate to limit pathological nitric oxide overproduction |
ES2096524B1 (es) * | 1994-12-22 | 1997-11-16 | Sanchez Manuel Guerra | Uso de la ng-monometil-l-arginina, para aumentar la capacidad de hacer ejercicio fisico. |
ES2206571T3 (es) * | 1995-04-20 | 2004-05-16 | G.D. SEARLE & CO. | Agentes de amidino ciclico utiles como inhibidores de la oxido nitrico sintasa. |
US5945408A (en) * | 1996-03-06 | 1999-08-31 | G.D. Searle & Co. | Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
US20020031513A1 (en) * | 1997-11-24 | 2002-03-14 | Shamir Leibovitz | Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals |
CA2333691A1 (en) | 1998-06-10 | 1999-12-16 | G.D. Searle & Co. | Heterobicyclic and tricyclic nitric oxide synthase inhibitors |
WO2001052902A1 (en) * | 2000-01-24 | 2001-07-26 | Isis Pharmaceuticals, Inc. | Antisense modulation of inducible nitric oxide synthase expression |
WO2001078717A1 (en) | 2000-04-12 | 2001-10-25 | Cornell Research Foundation, Inc. | Pharmacotherapy for vascular dysfunction associated with deficient nitric oxide bioactivity |
US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
US9572856B2 (en) * | 2009-12-16 | 2017-02-21 | The George Washington University a Congressionally Chartered Not-for-Profit Corporation | Method of treating low blood pressure |
AU2014256944B2 (en) | 2013-04-26 | 2019-06-27 | La Jolla Pharma, Llc | Compositions and methods for treating renal failure |
SI2986308T1 (sl) | 2013-12-18 | 2020-03-31 | The George Washington University, A Congressionally Chartered Not-For-Profit Corporation | Angiotenzin II v kombinaciji za zdravljenje hipotenzije |
TW201733610A (zh) | 2016-01-07 | 2017-10-01 | 拉荷亞製藥公司 | 投與血管收縮素ii之方法 |
WO2018191678A1 (en) | 2017-04-14 | 2018-10-18 | La Jolla Pharmaceutical Company | Methods for administering angiotensin ii |
US20220288164A1 (en) * | 2019-08-20 | 2022-09-15 | Georgetown University | Method to increase systemic blood pressure in shock |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1127322B (it) * | 1979-12-28 | 1986-05-21 | Italfarmaco Spa | Composizioni farmaceutiche con esaltazione dell'attivita' terapeutica di cortisonici |
US4734438A (en) * | 1983-04-26 | 1988-03-29 | Macri Frank J | Norepinephrine potentiated compositions and method of use |
FR2637119A1 (fr) * | 1988-09-23 | 1990-03-30 | Thomson Csf | Dispositif de commande manuelle par entrainement d'un bouton en rotation |
DE3838461A1 (de) * | 1988-11-12 | 1990-05-23 | Krebsoege Gmbh Sintermetall | Pulvermetallurgischer werkstoff auf kupferbasis und dessen verwendung |
US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
US5059712A (en) * | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
-
1991
- 1991-07-01 US US07/723,480 patent/US5216025A/en not_active Expired - Lifetime
-
1992
- 1992-07-01 EP EP92914870A patent/EP0592557B1/de not_active Expired - Lifetime
- 1992-07-01 JP JP5502318A patent/JPH06508849A/ja not_active Ceased
- 1992-07-01 WO PCT/US1992/005570 patent/WO1993000893A1/en active IP Right Grant
- 1992-07-01 AT AT92914870T patent/ATE189386T1/de not_active IP Right Cessation
- 1992-07-01 CA CA002111345A patent/CA2111345A1/en not_active Abandoned
- 1992-07-01 DE DE69230641T patent/DE69230641T2/de not_active Expired - Fee Related
- 1992-07-01 AU AU23080/92A patent/AU659664B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU2308092A (en) | 1993-02-11 |
US5216025A (en) | 1993-06-01 |
ATE189386T1 (de) | 2000-02-15 |
EP0592557A1 (de) | 1994-04-20 |
EP0592557B1 (de) | 2000-02-02 |
EP0592557A4 (de) | 1994-08-03 |
CA2111345A1 (en) | 1993-01-21 |
JPH06508849A (ja) | 1994-10-06 |
DE69230641D1 (de) | 2000-03-09 |
WO1993000893A1 (en) | 1993-01-21 |
AU659664B2 (en) | 1995-05-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69230641D1 (de) | Inhibitoren der stickstoffoxidsynthese zur potenzierung der wirkung von blutdruckwirksamen mitteln bei gewissen hypotonikern | |
DE69034206D1 (de) | Argininantagonisten zur Hemmung des systemischen Blutdruckes in Zusammenhang mitStickoxidbildung oder Endothelial Derived Relaxing Factor | |
NO924326L (no) | Antitrombosemidler | |
EP0303465A3 (de) | Phenethanolamin-Derivate | |
Borth et al. | Binding of IL-1 beta to alpha-macroglobulins and release by thioredoxin. | |
UA26375A1 (uk) | Спосіб очищеhhя іhсуліhу | |
SE9101838D0 (sv) | Novel peptides and their use | |
KR910001068A (ko) | 항생제 | |
DK0804465T3 (da) | Nye elastaseinhibitorer | |
DE69023006D1 (de) | Verfahren zur behandlung von thrombocytopenie und dafür geeignete pharmazeutische zusammensetzungen. | |
NO894720L (no) | Farmasoeytisk aktivt protein. | |
DE69637812D1 (de) | Schützende Epitope von Adenylate-Zyklase-Hämolysin(AC-Hly) und ihre Verwendung zur Behandlung oder Verhütung von Bordetella-Infektionen | |
BR0213633A (pt) | Método e composto para tratar de uma doença associada com recrutamento e/ou ativação aberrante de leucócitos | |
DE69834929D1 (de) | Verwendung eines organspezifischen ernährungmittels | |
DK0609242T3 (da) | Nyt thrombininhibitorisk protein fra blodmider | |
ES2097931T3 (es) | Nueva proteina inhibidora de trombina a partir de chinches cazadoras. | |
DE68908958D1 (de) | Peptide. | |
ES2123570T3 (es) | Uso de la molecula de adhesion de leucocitos y endotelios 1 y anticuerpos contra ella en el tratamiento del asma. | |
ATE133860T1 (de) | Tumor-nekrose-faktor-antagonist | |
RU94046312A (ru) | Применение биологически активных уреидопроизводных для лечения индуцируемых лентивирусами заболеваний, продукты, содержащие уреидопроизводные | |
DE69306794T2 (de) | Alkylamino-ethynyl-alanin-aminodiolverbindungen mit imidazolyl/benzimidazolyl-endgruppe zur behandlung von bluthochdruck | |
EP0391180A3 (de) | Peptidartige Aminosäurederivate mit reninhemmender Wirkung | |
Brooks et al. | Effect of secretin on gastric acid secretion stimulated by gastrin II, caerulein and desulfated caerulein | |
RU94026088A (ru) | Способ лечения шока и способ ингибирования продуцирования альфа фактора некроза опухоли | |
DE69131248T2 (de) | Inhibition der ausscheidung von natrium durch die na-k-atpase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |