DE69230926D1 - Benzimidazolonderivate als 5-HT1A und 5-HT2-Antagonisten - Google Patents
Benzimidazolonderivate als 5-HT1A und 5-HT2-AntagonistenInfo
- Publication number
- DE69230926D1 DE69230926D1 DE69230926T DE69230926T DE69230926D1 DE 69230926 D1 DE69230926 D1 DE 69230926D1 DE 69230926 T DE69230926 T DE 69230926T DE 69230926 T DE69230926 T DE 69230926T DE 69230926 D1 DE69230926 D1 DE 69230926D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- substituted
- mono
- optionally
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI912118A IT1251144B (it) | 1991-07-30 | 1991-07-30 | Derivati del benzimidazolone |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69230926D1 true DE69230926D1 (de) | 2000-05-25 |
DE69230926T2 DE69230926T2 (de) | 2000-10-05 |
Family
ID=11360463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69230926T Expired - Lifetime DE69230926T2 (de) | 1991-07-30 | 1992-07-30 | Benzimidazolonderivate als 5-HT1A und 5-HT2-Antagonisten |
Country Status (32)
Country | Link |
---|---|
US (1) | US5576318A (de) |
EP (1) | EP0526434B1 (de) |
JP (1) | JP2989667B2 (de) |
KR (1) | KR100263495B1 (de) |
AT (1) | ATE191910T1 (de) |
AU (1) | AU665366B2 (de) |
CA (1) | CA2114542C (de) |
CZ (1) | CZ281511B6 (de) |
DE (1) | DE69230926T2 (de) |
DK (1) | DK0526434T3 (de) |
EE (1) | EE03070B1 (de) |
ES (1) | ES2144412T3 (de) |
FI (1) | FI111460B (de) |
GR (1) | GR3033947T3 (de) |
HK (1) | HK1010725A1 (de) |
HU (2) | HUT70195A (de) |
IE (1) | IE922464A1 (de) |
IL (1) | IL102665A (de) |
IT (1) | IT1251144B (de) |
MX (1) | MX9204139A (de) |
NO (1) | NO304070B1 (de) |
NZ (1) | NZ243777A (de) |
PH (1) | PH30998A (de) |
PL (1) | PL171329B1 (de) |
PT (1) | PT526434E (de) |
RU (1) | RU2096411C1 (de) |
SG (1) | SG52407A1 (de) |
SK (1) | SK279292B6 (de) |
TW (1) | TW209862B (de) |
UA (1) | UA42684C2 (de) |
WO (1) | WO1993003016A1 (de) |
ZA (1) | ZA925682B (de) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
US5266571A (en) * | 1992-01-09 | 1993-11-30 | Amer Moh Samir | Treatment of hemorrhoids with 5-HT2 antagonists |
SE9201138D0 (sv) * | 1992-04-09 | 1992-04-09 | Astra Ab | Novel phthalimidoalkylpiperazines |
DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
AU6391894A (en) * | 1993-03-16 | 1994-10-11 | Pfizer Inc. | Naphthalene derivatives |
JP3719612B2 (ja) * | 1993-06-14 | 2005-11-24 | 塩野義製薬株式会社 | ヘテロ環を含有する尿素誘導体 |
IL114027A (en) * | 1994-06-08 | 1999-11-30 | Lundbeck & Co As H | 4-Phenyl piperazine (piperidine or tetrahydropyridine) derivatives serotinin 5-HT1A and dopamin D2 receptor ligand pharmaceutical compositions containing them |
CA2192975C (en) * | 1994-06-14 | 1999-09-21 | Anton F. Fliri | Benzimidazolone derivatives |
CA2196769C (en) * | 1994-08-05 | 2002-10-08 | William S. Faraci | Benzimidazole derivatives having dopaminergic activity |
US5883094A (en) * | 1995-04-24 | 1999-03-16 | Pfizer Inc. | Benzimidazolone derivatives with central dopaminergic activity |
US5889010A (en) * | 1995-05-18 | 1999-03-30 | Pfizer Inc. | Benzimidazole derivatives having dopaminergic activity |
WO1997016187A1 (en) * | 1995-10-31 | 1997-05-09 | Merck & Co., Inc. | Muscarine antagonists |
EP1087954A1 (de) * | 1998-06-15 | 2001-04-04 | American Home Products Corporation | Cycloalkyl-substituiertte aryl-piperazine, piperidine und tetrahydropyridine als serotonergische agente |
US6376494B1 (en) | 1998-06-15 | 2002-04-23 | American Home Products Corporation | Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents |
AR022303A1 (es) * | 1999-01-22 | 2002-09-04 | Lundbeck & Co As H | Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion |
IT1313625B1 (it) * | 1999-09-22 | 2002-09-09 | Boehringer Ingelheim Italia | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. |
ATE341538T1 (de) * | 2000-09-19 | 2006-10-15 | Boehringer Ingelheim Pharma | Benzimidazolonderivate mit affinität zu serotonin-und dopaminrezeptoren |
CA2417081C (en) * | 2000-09-19 | 2008-08-05 | Enzo Cereda | New n, n'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors |
US6586435B2 (en) | 2000-09-19 | 2003-07-01 | Boehringer Ingelheim Pharma Kg | Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors |
US6521623B1 (en) | 2000-09-19 | 2003-02-18 | Boehringer Ingelheim Pharma Kg | N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors |
CA2453837C (en) * | 2001-07-20 | 2011-10-04 | Psychogenics, Inc. | Treatment for attention-deficit hyperactivity disorder using eltoprazine and related compounds |
US7183410B2 (en) * | 2001-08-02 | 2007-02-27 | Bidachem S.P.A. | Stable polymorph of flibanserin |
ATE288911T1 (de) * | 2001-08-02 | 2005-02-15 | Bidachem Spa | Stabiles polymorph von flibanserin, industrielles verfahren zu dessen herstellung und dessen verwendung zur herstellung von medikamenten |
US20030060475A1 (en) * | 2001-08-10 | 2003-03-27 | Boehringer Ingelheim Pharma Kg | Method of using flibanserin for neuroprotection |
DE10138273A1 (de) * | 2001-08-10 | 2003-02-27 | Boehringer Ingelheim Pharma | Arzneimittel mit neuroprotektiver Wirkung |
US10675280B2 (en) | 2001-10-20 | 2020-06-09 | Sprout Pharmaceuticals, Inc. | Treating sexual desire disorders with flibanserin |
UA78974C2 (en) | 2001-10-20 | 2007-05-10 | Boehringer Ingelheim Pharma | Use of flibanserin for treating disorders of sexual desire |
US20040048877A1 (en) * | 2002-05-22 | 2004-03-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions containing flibanserin |
SI1511489T1 (sl) * | 2002-05-22 | 2011-06-30 | Boehringer Ingelheim Pharma | Novi farmacevtski sestavki, ki vsebujejo polimorf A flibanserina |
OA12923A (en) * | 2002-09-17 | 2006-10-13 | Warner Lambert Co | Heterocyclic substituted piperazines for the treatment of schizophrenia. |
PT1664036E (pt) * | 2003-09-03 | 2012-02-16 | Pfizer | Compostos de benzimidazolona que possuem actividade agonística do receptor 5-ht4 |
MXPA06012059A (es) * | 2004-04-22 | 2007-01-25 | Boehringer Ingelheim Int | Nuevas composiciones farmaceuticas para el tratamiento de los trastornos sexuales ii. |
US20050239798A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for the treatment of premenstrual and other female sexual disorders |
US7737163B2 (en) * | 2004-06-15 | 2010-06-15 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
EP1758891A2 (de) * | 2004-06-15 | 2007-03-07 | Pfizer Japan Inc. | Benzimidazoloncarbonsäurederivate |
US20060014757A1 (en) * | 2004-07-14 | 2006-01-19 | Boehringer Ingelheim Pharmaceuticals | Method for the treatment of anorexia nervosa |
US20060025420A1 (en) * | 2004-07-30 | 2006-02-02 | Boehringer Ingelheimn International GmbH | Pharmaceutical compositions for the treatment of female sexual disorders |
EP1789048A1 (de) * | 2004-09-03 | 2007-05-30 | Boehringer Ingelheim International GmbH | Verfahren zur behandlung von aufmerksamkeitsdefizitstörung mit hyperaktivität |
JP4130220B1 (ja) * | 2005-02-22 | 2008-08-06 | ファイザー株式会社 | 5ht4受容体アゴニストとしてのオキシインドール誘導体 |
WO2006096439A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases |
JP2008538741A (ja) * | 2005-03-04 | 2008-11-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 鬱病の治療用及び/又は予防用の医薬組成物 |
WO2006096434A2 (en) * | 2005-03-04 | 2006-09-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders |
CA2608249A1 (en) * | 2005-05-06 | 2006-11-16 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug abuse with flibanserin |
CA2608713A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of sexual dysfunctions due to medical conditions |
US20060264511A1 (en) * | 2005-05-19 | 2006-11-23 | Boehringer Ingelheim International Gmbh | Method for the treatment of drug-induced sexual dysfunction |
US8227476B2 (en) | 2005-08-03 | 2012-07-24 | Sprout Pharmaceuticals, Inc. | Use of flibanserin in the treatment of obesity |
US7790726B2 (en) * | 2005-08-16 | 2010-09-07 | Chemocentryx, Inc. | Monocyclic and bicyclic compounds and methods of use |
EP1945214A1 (de) * | 2005-10-29 | 2008-07-23 | Boehringer Ingelheim International GmbH | Benzimidazolon-derivate zur behandlung von prämenstruellen und anderen sexuellen störungen der frau |
US20070123540A1 (en) * | 2005-10-29 | 2007-05-31 | Angelo Ceci | Sexual desire enhancing medicaments comprising benzimidazolone derivatives |
US20070105869A1 (en) * | 2005-11-08 | 2007-05-10 | Stephane Pollentier | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders |
JP2009527525A (ja) * | 2006-02-20 | 2009-07-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 尿失禁治療用のベンゾイミダゾロン誘導体 |
EP1988077A4 (de) * | 2006-02-23 | 2009-09-02 | Shionogi & Co | Nitrogene heterocyclische derivate, die mit cyclischen gruppen substituiert sind |
CA2642368A1 (en) * | 2006-02-28 | 2007-09-07 | Boehringer Ingelheim International Gmbh | Treatment of prevention of valvular heart disease with flibanserin |
CA2649938A1 (en) * | 2006-05-09 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Use of flibanserin for the treatment of post-menopausal sexual desire disorders |
ATE456369T1 (de) | 2006-06-30 | 2010-02-15 | Boehringer Ingelheim Int | Flibanserin zur behandlung von harninkontinenz und assoziierten erkrankungen |
CA2657043A1 (en) * | 2006-07-14 | 2008-01-17 | Boehringer Ingelheim International Gmbh | Use of flibanserin for the treatment of sexual disorders in females |
CL2007002214A1 (es) | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
WO2008019996A2 (en) | 2006-08-14 | 2008-02-21 | Boehringer Ingelheim International Gmbh | Formulations of flibanserin and method for manufacturing the same |
MX2009002031A (es) | 2006-08-25 | 2009-03-06 | Boehringer Ingelheim Int | Sistema de liberacion controlada y metodo para fabricarlo. |
CA2672957C (en) | 2006-12-20 | 2015-04-14 | Boehringer Ingelheim International Gmbh | Sulfated benzimidazolone derivatives having mixed serotonine receptor affinity |
WO2008090742A1 (ja) * | 2007-01-23 | 2008-07-31 | National University Corporation Hokkaido University | 眼疾患モデル用非ヒト動物 |
JP5514716B2 (ja) * | 2007-05-11 | 2014-06-04 | コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー | アリールピペリジン置換基を有するイミダゾール誘導体、その製造方法及びこれを含む医薬組成物 |
CL2008002693A1 (es) | 2007-09-12 | 2009-10-16 | Boehringer Ingelheim Int | Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad |
US20110028490A1 (en) * | 2008-01-24 | 2011-02-03 | Neurosearch A/S | 4-phenyl-piperazin-1-yl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake in-hibitors |
EP2090297A1 (de) | 2008-02-13 | 2009-08-19 | Boehringer Ingelheim International GmbH | Formulierungen aus Flibanserin |
CA2686480A1 (en) * | 2008-12-15 | 2010-06-15 | Boehringer Ingelheim International Gmbh | New salts |
WO2010146595A2 (en) * | 2009-06-16 | 2010-12-23 | Symed Labs Limited | Novel polymorphs of flibanserin hydrochloride |
BRPI1003506B1 (pt) | 2010-09-24 | 2019-12-03 | Ache Int Bvi Ltd | composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a |
EA029054B1 (ru) * | 2012-10-11 | 2018-02-28 | Саузерн Рисерч Инститьют | Мочевинные и амидные производные аминоалкилпиперазинов и их применение |
CN104926734B (zh) * | 2015-07-07 | 2017-04-05 | 苏州立新制药有限公司 | 氟班色林的制备方法 |
WO2017076213A1 (zh) * | 2015-11-02 | 2017-05-11 | 苏州旺山旺水生物医药有限公司 | 苯并咪唑类化合物、其制备方法及用途 |
WO2017076356A1 (zh) * | 2015-11-05 | 2017-05-11 | 苏州晶云药物科技有限公司 | 氟班色林的新晶型及其制备方法 |
CN106749038A (zh) * | 2015-11-25 | 2017-05-31 | 山东诚创医药技术开发有限公司 | 一种氟班色林的制备方法 |
CN106866546A (zh) * | 2015-12-10 | 2017-06-20 | 常州爱诺新睿医药技术有限公司 | 氟班色林或其药学上可接受的盐与药用辅料的固体分散体及其制备方法 |
CN113683570A (zh) | 2016-01-31 | 2021-11-23 | 孟晓明 | 氟班色林的新晶型及其制备方法及其用途 |
WO2017133337A1 (zh) * | 2016-02-02 | 2017-08-10 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的苯并咪唑酮化合物及包含该化合物的组合物 |
CN107235913B (zh) * | 2016-03-29 | 2020-07-10 | 苏州科伦药物研究有限公司 | 工业规模高效制造优质氟班色林的方法 |
CN106866582A (zh) * | 2017-01-10 | 2017-06-20 | 广州隽沐生物科技有限公司 | 一种氟班色林中间体的制备方法 |
HU231283B1 (hu) | 2018-08-01 | 2022-09-28 | Richter Gedeon Nyrt | Eljárás a flibanserin többlépéses folyamatos áramú előállítására |
EP4308119A1 (de) * | 2021-03-19 | 2024-01-24 | Centre National de la Recherche Scientifique | <sup2/>? <sub2/>?7?anwendungen von vorbelasteten serotonin 5-ht-rezeptor liganden zur behandlung von schmerzen, multipler sklerose und kontrolle der thermoregulation |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3406178A (en) * | 1964-02-04 | 1968-10-15 | Monsanto Chem Australia Ltd | Preparation of 2-substituted benzimidazoles |
US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
YU39992B (en) * | 1976-04-02 | 1985-06-30 | Janssen Pharmaceutica Nv | Process for obtaining new piperazine and piperidine derivatives |
IL57569A0 (en) * | 1978-06-20 | 1979-10-31 | Synthelabo | Phenylpiperazine derivative,their preparation and pharmaceutical compositions containing them |
IT1176613B (it) * | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
GB8607294D0 (en) * | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
HUT43600A (en) * | 1985-06-22 | 1987-11-30 | Sandoz Ag | Process for production of new thiazole derivatives and medical compound containing those |
GB8601160D0 (en) * | 1986-01-17 | 1986-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compounds |
US5036088A (en) * | 1986-06-09 | 1991-07-30 | Pfizer Inc. | Antiallergy and antiinflammatory agents, compositions and use |
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US4954503A (en) * | 1989-09-11 | 1990-09-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(1-substituted-4-piperazinyl)-1H-indazoles |
IT1251144B (it) * | 1991-07-30 | 1995-05-04 | Boehringer Ingelheim Italia | Derivati del benzimidazolone |
-
1991
- 1991-07-30 IT ITMI912118A patent/IT1251144B/it active IP Right Grant
-
1992
- 1992-07-15 MX MX9204139A patent/MX9204139A/es unknown
- 1992-07-28 TW TW081105974A patent/TW209862B/zh not_active IP Right Cessation
- 1992-07-28 IL IL10266592A patent/IL102665A/en not_active IP Right Cessation
- 1992-07-29 ZA ZA925682A patent/ZA925682B/xx unknown
- 1992-07-29 PH PH44739A patent/PH30998A/en unknown
- 1992-07-29 IE IE246492A patent/IE922464A1/en not_active IP Right Cessation
- 1992-07-30 AT AT92830427T patent/ATE191910T1/de active
- 1992-07-30 SG SG1996004034A patent/SG52407A1/en unknown
- 1992-07-30 JP JP50345393A patent/JP2989667B2/ja not_active Expired - Lifetime
- 1992-07-30 PL PL92302163A patent/PL171329B1/pl unknown
- 1992-07-30 CA CA002114542A patent/CA2114542C/en not_active Expired - Lifetime
- 1992-07-30 NZ NZ243777A patent/NZ243777A/en unknown
- 1992-07-30 AU AU24275/92A patent/AU665366B2/en not_active Expired
- 1992-07-30 CZ CZ94170A patent/CZ281511B6/cs not_active IP Right Cessation
- 1992-07-30 SK SK101-94A patent/SK279292B6/sk unknown
- 1992-07-30 EP EP92830427A patent/EP0526434B1/de not_active Expired - Lifetime
- 1992-07-30 PT PT92830427T patent/PT526434E/pt unknown
- 1992-07-30 KR KR1019940700293A patent/KR100263495B1/ko not_active IP Right Cessation
- 1992-07-30 ES ES92830427T patent/ES2144412T3/es not_active Expired - Lifetime
- 1992-07-30 RU RU9294015171A patent/RU2096411C1/ru active
- 1992-07-30 WO PCT/IT1992/000088 patent/WO1993003016A1/en active IP Right Grant
- 1992-07-30 UA UA94005462A patent/UA42684C2/uk unknown
- 1992-07-30 DK DK92830427T patent/DK0526434T3/da active
- 1992-07-30 DE DE69230926T patent/DE69230926T2/de not_active Expired - Lifetime
- 1992-07-30 HU HU9400255A patent/HUT70195A/hu unknown
-
1994
- 1994-01-28 NO NO940306A patent/NO304070B1/no not_active IP Right Cessation
- 1994-01-28 FI FI940420A patent/FI111460B/fi not_active IP Right Cessation
- 1994-03-23 US US08/216,742 patent/US5576318A/en not_active Expired - Lifetime
- 1994-11-23 EE EE9400396A patent/EE03070B1/xx unknown
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1995
- 1995-06-20 HU HU95P/P00292P patent/HU211256A9/hu unknown
-
1998
- 1998-10-21 HK HK98111444A patent/HK1010725A1/xx not_active IP Right Cessation
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2000
- 2000-07-12 GR GR20000401632T patent/GR3033947T3/el unknown
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