DE69231195D1 - Verfahren zur Herstellung diagnostischer Mittel - Google Patents

Verfahren zur Herstellung diagnostischer Mittel

Info

Publication number
DE69231195D1
DE69231195D1 DE69231195T DE69231195T DE69231195D1 DE 69231195 D1 DE69231195 D1 DE 69231195D1 DE 69231195 T DE69231195 T DE 69231195T DE 69231195 T DE69231195 T DE 69231195T DE 69231195 D1 DE69231195 D1 DE 69231195D1
Authority
DE
Germany
Prior art keywords
microcapsules
wall
methods
diagnostic agents
forming material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69231195T
Other languages
English (en)
Other versions
DE69231195T2 (de
Inventor
Andrew Derek Sutton
Richard Alan Johnson
Peter James Senior
David Heath
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Drug Delivery Ltd
Original Assignee
QUADRANT HEALTHCARE (UK) Ltd RUDDINGTON
Quadrant Healthcare UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10693031&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69231195(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by QUADRANT HEALTHCARE (UK) Ltd RUDDINGTON, Quadrant Healthcare UK Ltd filed Critical QUADRANT HEALTHCARE (UK) Ltd RUDDINGTON
Application granted granted Critical
Publication of DE69231195D1 publication Critical patent/DE69231195D1/de
Publication of DE69231195T2 publication Critical patent/DE69231195T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B01J13/043—Drying and spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/928—Mixing combined with non-mixing operation or step, successively or simultaneously, e.g. heating, cooling, ph change, ageing, milling
DE69231195T 1991-04-10 1992-04-10 Verfahren zur Herstellung diagnostischer Mittel Expired - Fee Related DE69231195T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919107628A GB9107628D0 (en) 1991-04-10 1991-04-10 Preparation of diagnostic agents

Publications (2)

Publication Number Publication Date
DE69231195D1 true DE69231195D1 (de) 2000-08-03
DE69231195T2 DE69231195T2 (de) 2001-03-08

Family

ID=10693031

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69233148T Expired - Fee Related DE69233148T2 (de) 1991-04-10 1992-04-10 Verfahren zur Herstellung von diagnostischen Mitteln
DE69233489T Expired - Fee Related DE69233489T2 (de) 1991-04-10 1992-04-10 Verfahren zur Herstellung von Diagnostica
DE69231195T Expired - Fee Related DE69231195T2 (de) 1991-04-10 1992-04-10 Verfahren zur Herstellung diagnostischer Mittel

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69233148T Expired - Fee Related DE69233148T2 (de) 1991-04-10 1992-04-10 Verfahren zur Herstellung von diagnostischen Mitteln
DE69233489T Expired - Fee Related DE69233489T2 (de) 1991-04-10 1992-04-10 Verfahren zur Herstellung von Diagnostica

Country Status (24)

Country Link
US (3) US5518709A (de)
EP (6) EP0972526B1 (de)
JP (2) JP2865866B2 (de)
KR (1) KR0129861B1 (de)
CN (1) CN1066977A (de)
AT (3) ATE290405T1 (de)
AU (2) AU655016B2 (de)
CA (1) CA2083260A1 (de)
DE (3) DE69233148T2 (de)
DK (3) DK0512693T3 (de)
ES (3) ES2242355T3 (de)
FI (1) FI925600A0 (de)
GB (2) GB9107628D0 (de)
GR (1) GR3034462T3 (de)
HK (1) HK1006538A1 (de)
HU (1) HUT62805A (de)
IE (1) IE921140A1 (de)
IL (2) IL101564A (de)
MX (1) MX9201694A (de)
NZ (1) NZ242328A (de)
PT (2) PT681843E (de)
RU (1) RU2109521C1 (de)
WO (1) WO1992018164A1 (de)
ZA (1) ZA922636B (de)

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