DE69231473D1 - Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo - Google Patents
Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivoInfo
- Publication number
- DE69231473D1 DE69231473D1 DE69231473T DE69231473T DE69231473D1 DE 69231473 D1 DE69231473 D1 DE 69231473D1 DE 69231473 T DE69231473 T DE 69231473T DE 69231473 T DE69231473 T DE 69231473T DE 69231473 D1 DE69231473 D1 DE 69231473D1
- Authority
- DE
- Germany
- Prior art keywords
- advanced glycosylation
- disclosed
- age
- vivo
- glycosylation endproducts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/723—Glycosylated haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81157991A | 1991-12-20 | 1991-12-20 | |
US07/956,849 US5624804A (en) | 1991-12-20 | 1992-10-01 | Immunochemical detection of In vivo advanced glycosylation end products |
PCT/US1992/011158 WO1993013421A1 (en) | 1991-12-20 | 1992-12-21 | Immunochemical detection of in vivo advanced glycosylation endproducts |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69231473D1 true DE69231473D1 (de) | 2000-10-26 |
DE69231473T2 DE69231473T2 (de) | 2001-02-08 |
Family
ID=27123501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69231473T Expired - Fee Related DE69231473T2 (de) | 1991-12-20 | 1992-12-21 | Immunochemischer nachweiss von endprodukten der fortgeschrittenen glycosylation in vivo |
Country Status (12)
Country | Link |
---|---|
US (6) | US5624804A (de) |
EP (1) | EP0623216B1 (de) |
JP (1) | JPH07502534A (de) |
KR (1) | KR100257733B1 (de) |
CN (1) | CN1053964C (de) |
AT (1) | ATE196549T1 (de) |
AU (1) | AU681340B2 (de) |
CA (1) | CA2126209A1 (de) |
DE (1) | DE69231473T2 (de) |
ES (1) | ES2150936T3 (de) |
PT (1) | PT101147A (de) |
WO (1) | WO1993013421A1 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869534A (en) * | 1992-05-21 | 1999-02-09 | The Picower Institute For Medical Research | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
US7585512B1 (en) * | 1990-05-08 | 2009-09-08 | Thomas Jefferson University | Composition and method of using tumor cells |
US5624804A (en) * | 1991-12-20 | 1997-04-29 | The Rockefeller University | Immunochemical detection of In vivo advanced glycosylation end products |
AU712004B2 (en) * | 1993-03-11 | 1999-10-28 | Picower Institute For Medical Research, The | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
WO1995020979A1 (en) * | 1994-02-03 | 1995-08-10 | The Picower Institute For Medical Research | Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis |
US6410598B1 (en) | 1994-02-03 | 2002-06-25 | Michael P. Vitek | Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis |
US5610076A (en) * | 1994-04-29 | 1997-03-11 | Alteon Inc. | Method for detecting hemoglobin advanced glycosylation endproducts |
US5744318A (en) * | 1994-12-30 | 1998-04-28 | Alteon Inc. | Monoclonal antibody for the detection of advanced glycosylation endproducts in biological samples |
AU693992B2 (en) * | 1994-12-30 | 1998-07-09 | Alteon Inc. | Monoclonal antibodies specific for advanced glycosylation endproducts in biological samples |
PT808163E (pt) * | 1995-01-18 | 2003-12-31 | Alteon Inc | Uso de compostos de tiazolio para prevencao e inversao da formacao de produtos finais com glicosilacao avancada |
US5811242A (en) * | 1995-10-24 | 1998-09-22 | Tokuyama Corporation | Marker and reagent for diabetes mellitus and diabetes mellitus complication |
US5811401A (en) * | 1995-11-30 | 1998-09-22 | The Picower Institute For Medical Research | Advanced glycosylation endproducts and methods of use therefor |
CA2241924A1 (en) * | 1995-12-26 | 1997-07-03 | The Picower Institute For Medical Research | Methods for measurement and treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts |
AU1431397A (en) * | 1995-12-29 | 1997-07-28 | Alteon Inc. | 6-(n-carboxymethylamino)caproate, salts thereof and methods of use therefor |
US6033862A (en) * | 1996-10-30 | 2000-03-07 | Tokuyama Corporation | Marker and immunological reagent for dialysis-related amyloidosis, diabetes mellitus and diabetes mellitus complications |
US6380165B1 (en) * | 1997-09-19 | 2002-04-30 | The Picower Institute For Medical Research | Immunological advanced glycation endproduct crosslink |
US20020091324A1 (en) * | 1998-04-06 | 2002-07-11 | Nikiforos Kollias | Non-invasive tissue glucose level monitoring |
US6721582B2 (en) | 1999-04-06 | 2004-04-13 | Argose, Inc. | Non-invasive tissue glucose level monitoring |
US6728560B2 (en) | 1998-04-06 | 2004-04-27 | The General Hospital Corporation | Non-invasive tissue glucose level monitoring |
US7899518B2 (en) * | 1998-04-06 | 2011-03-01 | Masimo Laboratories, Inc. | Non-invasive tissue glucose level monitoring |
US6505059B1 (en) | 1998-04-06 | 2003-01-07 | The General Hospital Corporation | Non-invasive tissue glucose level monitoring |
CN2445326Y (zh) * | 2000-10-09 | 2001-08-29 | 刘永详 | 测定被糖化蛋白的免疫分析装置 |
ES2231601T3 (es) * | 2001-03-22 | 2005-05-16 | F. Hoffmann-La Roche Ag | Metodo para la seleccion de reactivos y componentes en fase solida en ensayos de union especifica libres de productos finales de glicosilacion avanzados. |
MY140679A (en) * | 2001-05-24 | 2010-01-15 | Avanir Pharmaceuticals | Inhibitors of macrohage migration inhibitory factor and methods for identifying the same |
GB0221686D0 (en) * | 2002-09-19 | 2002-10-30 | Univ Ulster | Biomarker |
TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
WO2005021546A1 (en) * | 2003-08-22 | 2005-03-10 | Avanir Pharmaceuticals | Substituted naphthyridine derivatives as inhibitors of macrophage migration inhibitory factor and their use in the treatment of human diseases |
CN100489526C (zh) * | 2004-01-16 | 2009-05-20 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种人脑红蛋白检测及诊断试剂盒,其制备方法及用途 |
EP1861407A1 (de) * | 2005-03-24 | 2007-12-05 | Avanir Pharmaceuticals | Thienopyridinonderivate als hemmer des makrophagenmigrationshemmfaktors |
GB0605689D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
EP2339346B1 (de) * | 2006-03-24 | 2014-09-03 | Metanomics GmbH | Verfahren zur Prognose von Diabetes Typ II |
DE102006026173A1 (de) * | 2006-06-06 | 2007-12-20 | Fachhochschule Südwestfalen | Verfahren zur nichtinvasiven Diagnose von Diabetes |
ES2616728T3 (es) | 2008-05-23 | 2017-06-14 | Siwa Corporation | Procedimientos y composiciones para facilitar la regeneración |
WO2011040599A1 (ja) | 2009-10-02 | 2011-04-07 | シャープ株式会社 | 血管状態モニタリング装置およびモニタリング方法 |
JP5386634B2 (ja) * | 2010-03-19 | 2014-01-15 | シャープ株式会社 | 測定結果処理装置、測定システム、測定結果処理方法、制御プログラムおよび記録媒体 |
US9649376B2 (en) | 2010-09-27 | 2017-05-16 | Siwa Corporation | Selective removal of age-modified cells for treatment of atherosclerosis |
US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
KR101939401B1 (ko) * | 2011-11-10 | 2019-01-16 | 가천대학교 산학협력단 | 단핵식세포계 세포의 age-알부민 합성 또는 분비 저해제를 유효성분으로 포함하는 허혈성 심장질환 예방 또는 치료용 조성물 |
AU2015318036B2 (en) * | 2014-09-19 | 2021-07-01 | Siwa Corporation | Anti-AGE antibodies for treating inflammation and auto-immune disorders |
US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
KR20180056689A (ko) * | 2015-10-13 | 2018-05-29 | 시와 코퍼레이션 | 항-age 항체 및 이의 사용 방법 |
JP6553491B2 (ja) * | 2015-11-26 | 2019-07-31 | オリエンタル酵母工業株式会社 | 最終糖化産物(AGEs)が関連する疾患の罹患又はそのリスクを予測する方法 |
CA3021150C (en) | 2016-02-19 | 2023-02-07 | Siwa Corporation | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age) |
KR20180133452A (ko) | 2016-04-15 | 2018-12-14 | 시와 코퍼레이션 | 신경퇴행성 질환을 치료하기 위한 항-노화 항체 |
US11213585B2 (en) | 2016-06-23 | 2022-01-04 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
CN106769349B (zh) * | 2017-01-06 | 2020-01-21 | 上海君联医疗设备有限公司 | 血液中异常糖基化蛋白细胞的检测方法 |
US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
EP3609923A1 (de) | 2017-04-13 | 2020-02-19 | Siwa Corporation | Humanisierter monoklonaler advanced-glycation-endproduct-antikörper |
KR20200003067A (ko) | 2017-05-04 | 2020-01-08 | 시와 코퍼레이션 | 진단용 최종 당화 산물 항체 |
US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
CN108776131B (zh) * | 2018-03-19 | 2020-06-09 | 深圳市南山区疾病预防控制中心 | 一种食品中AGEs含量的检测方法 |
EP3826670A1 (de) | 2018-07-23 | 2021-06-02 | Siwa Corporation | Verfahren und zusammensetzungen zur behandlung chronischer effekte von strahlung und chemischer exposition |
US20210253739A1 (en) | 2018-08-23 | 2021-08-19 | Siwa Corporation | Anticarboxymethyl lysine antibodies and ultrasound for removing age-modified cells |
CN111040001B (zh) * | 2019-12-27 | 2021-04-16 | 山西医科大学 | 安定代谢物葡萄糖醛酸结合物的制备方法 |
WO2021222758A1 (en) | 2020-05-01 | 2021-11-04 | Siwa Corporation | Methods of treating infections |
WO2022093195A1 (en) | 2020-10-27 | 2022-05-05 | Siwa Corporation | Methods and compositions for treating osteoarthritis using anti-age antibodies or age antigens |
US20240000930A1 (en) | 2020-12-09 | 2024-01-04 | Siwa Corporation | Methods and compositions for treating kidney diseases |
CA3229602A1 (en) | 2021-08-20 | 2023-02-23 | Siwa Corporation | Methods and compositions for treating fibrotic diseases |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3654090A (en) * | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
NL154598B (nl) * | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US4016043A (en) * | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
US4867973A (en) * | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
JPH0766253B2 (ja) * | 1986-06-20 | 1995-07-19 | 松下電器産業株式会社 | マトリクス型画像表示装置 |
AU600306B2 (en) * | 1986-09-12 | 1990-08-09 | Rockefeller University, The | Methods and agents for removing advanced glycosylation endproducts |
ES2059460T3 (es) * | 1987-09-17 | 1994-11-16 | Univ Rockefeller | Productos finales avanzados de glicosilacion y metodos correspondientes. |
US5223392A (en) * | 1988-01-25 | 1993-06-29 | Exocell, Inc. | Monoclonal antibodies against glycated albumin, hybrid cell lines producing these antibodies, and use therefore |
US5624804A (en) * | 1991-12-20 | 1997-04-29 | The Rockefeller University | Immunochemical detection of In vivo advanced glycosylation end products |
-
1992
- 1992-10-01 US US07/956,849 patent/US5624804A/en not_active Expired - Lifetime
- 1992-12-18 PT PT101147A patent/PT101147A/pt not_active Application Discontinuation
- 1992-12-19 CN CN92115235A patent/CN1053964C/zh not_active Expired - Fee Related
- 1992-12-21 KR KR1019940702138A patent/KR100257733B1/ko not_active IP Right Cessation
- 1992-12-21 EP EP93902713A patent/EP0623216B1/de not_active Expired - Lifetime
- 1992-12-21 WO PCT/US1992/011158 patent/WO1993013421A1/en active IP Right Grant
- 1992-12-21 AU AU34187/93A patent/AU681340B2/en not_active Ceased
- 1992-12-21 DE DE69231473T patent/DE69231473T2/de not_active Expired - Fee Related
- 1992-12-21 JP JP5511864A patent/JPH07502534A/ja active Pending
- 1992-12-21 ES ES93902713T patent/ES2150936T3/es not_active Expired - Lifetime
- 1992-12-21 CA CA002126209A patent/CA2126209A1/en not_active Abandoned
- 1992-12-21 AT AT93902713T patent/ATE196549T1/de not_active IP Right Cessation
-
1995
- 1995-06-07 US US08/476,381 patent/US5629408A/en not_active Expired - Lifetime
- 1995-06-07 US US08/487,055 patent/US5683887A/en not_active Expired - Lifetime
- 1995-06-07 US US08/486,513 patent/US5702704A/en not_active Expired - Lifetime
- 1995-06-07 US US08/472,398 patent/US5712101A/en not_active Expired - Fee Related
- 1995-06-07 US US08/484,869 patent/US5733546A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5683887A (en) | 1997-11-04 |
WO1993013421A1 (en) | 1993-07-08 |
US5712101A (en) | 1998-01-27 |
KR100257733B1 (ko) | 2000-06-01 |
ATE196549T1 (de) | 2000-10-15 |
CN1053964C (zh) | 2000-06-28 |
JPH07502534A (ja) | 1995-03-16 |
EP0623216A1 (de) | 1994-11-09 |
US5733546A (en) | 1998-03-31 |
US5702704A (en) | 1997-12-30 |
CA2126209A1 (en) | 1993-07-08 |
ES2150936T3 (es) | 2000-12-16 |
KR940704003A (ko) | 1994-12-12 |
EP0623216B1 (de) | 2000-09-20 |
US5624804A (en) | 1997-04-29 |
CN1079825A (zh) | 1993-12-22 |
US5629408A (en) | 1997-05-13 |
DE69231473T2 (de) | 2001-02-08 |
AU3418793A (en) | 1993-07-28 |
PT101147A (pt) | 1994-03-31 |
AU681340B2 (en) | 1997-08-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |