DE69231835T2 - Künstliche-Säuger-Chromosome - Google Patents
Künstliche-Säuger-ChromosomeInfo
- Publication number
- DE69231835T2 DE69231835T2 DE69231835T DE69231835T DE69231835T2 DE 69231835 T2 DE69231835 T2 DE 69231835T2 DE 69231835 T DE69231835 T DE 69231835T DE 69231835 T DE69231835 T DE 69231835T DE 69231835 T2 DE69231835 T2 DE 69231835T2
- Authority
- DE
- Germany
- Prior art keywords
- cell lines
- chromosomes
- centromeres
- dna sequences
- mammalian chromosomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/166—Animal cells resulting from interspecies fusion
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/759,558 US5288625A (en) | 1991-09-13 | 1991-09-13 | Mammalian artificial chromosomes |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69231835D1 DE69231835D1 (de) | 2001-06-28 |
DE69231835T2 true DE69231835T2 (de) | 2001-11-22 |
Family
ID=25056105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69231835T Expired - Fee Related DE69231835T2 (de) | 1991-09-13 | 1992-09-14 | Künstliche-Säuger-Chromosome |
Country Status (6)
Country | Link |
---|---|
US (1) | US5288625A (de) |
EP (1) | EP0532050B1 (de) |
JP (1) | JP3456715B2 (de) |
AT (1) | ATE201450T1 (de) |
CA (1) | CA2078189C (de) |
DE (1) | DE69231835T2 (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2042093C (en) * | 1990-05-09 | 2002-12-24 | Gyula Hadlaczky | Cell line carrying an excess of mammalian centromeres |
US6348353B1 (en) * | 1995-06-07 | 2002-02-19 | Case Western Reserve University | Artificial mammalian chromosome |
US5869294A (en) * | 1995-06-07 | 1999-02-09 | Case Western Reserve University | Method for stably cloning large repeating DNA sequences |
US5695967A (en) * | 1995-06-07 | 1997-12-09 | Case Western Reserve University | Method for stably cloning large repeating units of DNA |
US6632976B1 (en) * | 1995-08-29 | 2003-10-14 | Kirin Beer Kabushiki Kaisha | Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene |
WO1997016533A1 (en) * | 1995-10-31 | 1997-05-09 | The Regents Of The University Of California | Mammalian artificial chromosomes and methods of using same |
US6133503A (en) * | 1995-10-31 | 2000-10-17 | The Regents Of The University Of California | Mammalian artificial chromosomes and methods of using same |
US6025155A (en) * | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US6077697A (en) * | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US20030033617A1 (en) * | 1996-04-10 | 2003-02-13 | Gyula Hadlaczky | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US20020160970A1 (en) * | 1996-04-10 | 2002-10-31 | Gyula Hadlaczky | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
EP0928339B1 (de) * | 1996-08-26 | 2008-08-06 | Chromo Research, Inc. | Künstliche säuger chromosome |
US7119250B2 (en) * | 1997-06-03 | 2006-10-10 | The University Of Chicago | Plant centromere compositions |
US7227057B2 (en) | 1997-06-03 | 2007-06-05 | Chromatin, Inc. | Plant centromere compositions |
US6972197B1 (en) | 1999-03-18 | 2005-12-06 | The University Of Chicago | Plant chromosome compositions and methods |
US6900012B1 (en) * | 1997-06-03 | 2005-05-31 | The University Of Chicago | Plant artificial chromosome compositions and methods |
US7193128B2 (en) * | 1997-06-03 | 2007-03-20 | Chromatin, Inc. | Methods for generating or increasing revenues from crops |
US7235716B2 (en) | 1997-06-03 | 2007-06-26 | Chromatin, Inc. | Plant centromere compositions |
EP0986648A1 (de) * | 1997-06-03 | 2000-03-22 | Arch Development Corporation | Zusammensetzungen und verfahren basierend auf pflanzlichen artifiziellen chromosomen (plac) |
WO2000006715A1 (en) * | 1998-07-27 | 2000-02-10 | Genotypes Inc. | Automatic eukaryotic artificial chromosome vector |
US7989202B1 (en) | 1999-03-18 | 2011-08-02 | The University Of Chicago | Plant centromere compositions |
US6399374B1 (en) * | 1999-10-08 | 2002-06-04 | The Johns Hopkins University | Converting diploidy to haploidy for genetic diagnosis |
US6475794B1 (en) * | 1999-10-08 | 2002-11-05 | The Johns Hopkins University | Converting diploidy to haploidy for genetic diagnosis |
CN105483142A (zh) * | 2000-09-28 | 2016-04-13 | 生物源食物及科学公司 | 脂肪酸去饱和酶家族成员fad4、fad5、fad5-2和fad6及它们的应用 |
US7294511B2 (en) | 2001-03-22 | 2007-11-13 | Chromos Molecular Systems, Inc. | Methods for delivering nucleic acid molecules into cells and assessment thereof |
US20030186390A1 (en) * | 2001-03-22 | 2003-10-02 | De Jong Gary | Methods for delivering nucleic acid molecules into cells and assessment thereof |
US6936469B2 (en) | 2001-03-22 | 2005-08-30 | Chromos Molecular Systems Inc. | Methods for delivering nucleic acid molecules into cells and assessment thereof |
NZ529597A (en) | 2001-05-30 | 2005-12-23 | Chromos Molecular Systems Inc | Plant artificial chromosomes, uses thereof and methods of preparing plant artificial chromosomes |
US20030119104A1 (en) * | 2001-05-30 | 2003-06-26 | Edward Perkins | Chromosome-based platforms |
CA2463725A1 (en) | 2001-10-12 | 2003-11-06 | Spectral Genomics, Inc. | Compilations of nucleic acids and arrays and methods of using them |
US7439346B2 (en) * | 2001-10-12 | 2008-10-21 | Perkinelmer Las Inc. | Nucleic acids arrays and methods of use therefor |
US7330851B2 (en) * | 2003-08-18 | 2008-02-12 | Eaglehawk, Limited | Data security through dissembly of data elements or connections between elements |
US20070212689A1 (en) * | 2003-10-30 | 2007-09-13 | Bianchi Diana W | Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid |
EP1718754A1 (de) * | 2004-02-23 | 2006-11-08 | Chromatin, Inc. | Mit minichromosomen modifizierte pflanzen |
US20060174364A1 (en) * | 2004-03-01 | 2006-08-03 | Avigenics, Inc. | Artificial chromosomes and transchromosomic avians |
NZ554824A (en) | 2004-10-22 | 2010-10-29 | Revivicor Inc | Porcines that lack endogenous antibody chains and express exogenous immunoglobulins |
WO2007030510A2 (en) * | 2005-09-08 | 2007-03-15 | Chromatin Inc. | Plants modified with mini-chromosomes |
EP1981976A4 (de) * | 2006-01-20 | 2009-05-06 | Univ South Florida | Verfahren zur erstellung von transkriptosomenprofilen |
US8614089B2 (en) * | 2007-03-15 | 2013-12-24 | Chromatin, Inc. | Centromere sequences and minichromosomes |
EP2348827B1 (de) | 2008-10-27 | 2015-07-01 | Revivicor, Inc. | Immunsupprimierte huftiere |
EP2456894A4 (de) | 2009-07-23 | 2013-09-25 | Chromatin Inc | Sorghum-zentromer-sequenzen und -minichromosomen |
HU230368B1 (hu) | 2012-11-16 | 2016-03-29 | Magyar Tudományos Akadémia Szegedi Biológiai Kutatóközpont | Új módszer az emlős mesterséges kromoszóma több génnel való feltöltésére |
RU2018139465A (ru) | 2016-04-12 | 2020-05-13 | СИНПЛОЙД БАЙОТЕК, ЭлЭлСи | Способы создания синтетических хромосом, имеющих генные регуляторные системы, и их применение |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4608339A (en) * | 1983-10-25 | 1986-08-26 | Yoakum George H | Protoplast fusion method for high-frequency DNA transfection in human cells |
US4970162A (en) * | 1985-11-13 | 1990-11-13 | The United States Of America As Represented By The Department Of Health And Human Services | Human-mouse hybrid cell line expressing monocyte-macrophage properties |
US4935350A (en) * | 1985-11-18 | 1990-06-19 | Amgen | Materials and methods for controlling plasmid copy number and stability |
FR2593827B1 (fr) * | 1986-01-31 | 1989-12-22 | Inst Nat Sante Rech Med | Fragments d'adn utilisables dans des vecteurs pour le maintien hereditaire de genes etrangers a l'etat autonome dans des animaux transgeniques, procede pour leur obtention et applications biologiques |
CA2006011A1 (en) * | 1988-12-21 | 1990-06-21 | Cecilia Lo | Transgenic organisms and cells and methods of producing transgenic organisms and cells |
CA2042093C (en) * | 1990-05-09 | 2002-12-24 | Gyula Hadlaczky | Cell line carrying an excess of mammalian centromeres |
-
1991
- 1991-09-13 US US07/759,558 patent/US5288625A/en not_active Expired - Fee Related
-
1992
- 1992-09-14 JP JP24520692A patent/JP3456715B2/ja not_active Expired - Fee Related
- 1992-09-14 EP EP92115694A patent/EP0532050B1/de not_active Expired - Lifetime
- 1992-09-14 CA CA002078189A patent/CA2078189C/en not_active Expired - Fee Related
- 1992-09-14 DE DE69231835T patent/DE69231835T2/de not_active Expired - Fee Related
- 1992-09-14 AT AT92115694T patent/ATE201450T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0532050A2 (de) | 1993-03-17 |
EP0532050B1 (de) | 2001-05-23 |
CA2078189A1 (en) | 1993-03-14 |
US5288625A (en) | 1994-02-22 |
EP0532050A3 (en) | 1993-07-21 |
JPH07177881A (ja) | 1995-07-18 |
DE69231835D1 (de) | 2001-06-28 |
JP3456715B2 (ja) | 2003-10-14 |
CA2078189C (en) | 1999-12-14 |
ATE201450T1 (de) | 2001-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69231835D1 (de) | Künstliche-Säuger-Chromosome | |
DE69133310D1 (de) | Säuger-Zentromere mit menschlicher DNS, die mit einem dominanten Marker assoziiert sind | |
Stebbins | The basis of progressive evolution | |
ATE403733T1 (de) | Künstliche säuger chromosome | |
SG48760A1 (en) | Generation of xenogenetic antibodies | |
DK0791058T3 (da) | Anvendelse af en nukleotidsekvens, der koder for enzymet I-SCEI | |
ATE198355T1 (de) | Alpha-amidierende enzymzusammensetzungen und verfahren zu deren herstellung und verwendung | |
CA2169854A1 (en) | Enhanced expression in plants using non-translated leader sequences | |
NL300297I1 (nl) | Werkwijze voor het verkrijgen van expressie of voor het verbeteren van het expressieniveau van een gen | |
DE69128893T2 (de) | Genetische veränderung von endothelzellen | |
ATE120486T1 (de) | Vektor zur integrationsstellenunabhängigen genexpression in säugetier-wirtszellen. | |
DK224185A (da) | Vektor til inkorporering i gaercellers chromosomer | |
FI962268A0 (fi) | Homologinen, rekombinanttinen vasta-aineilmentämisjärjestelmä rottien tai hiirien soluille | |
SE8104700L (sv) | Eukaryotiskt autonomt replikerande segment | |
DE69809561T2 (de) | Zusammensetzung und verfahren zur regulierung von zellproliferation und zelltod | |
CO4810249A1 (es) | Metodo para la seleccion de plantas transformadas . | |
DK0596881T3 (da) | Ekspression i ikke-tumurale humane lymofoblastoider med en integrativ vektor | |
ATE125299T1 (de) | Synthetisches gen für menschliches parathyroidhormon. | |
NO974367L (no) | Vektorer samt fremgangsmåter for gen-ekspresjon i pattedyrceller | |
ATE259421T1 (de) | Dna-virus-vektoren und verfahren zu ihrer herstellung | |
DE69233339D1 (de) | Expressionsteigerung durch Gentargeting in endogene Retrovirus-ähnliche Sequenzen | |
Margulis | Cytoplasmic genes-our Precambrian legacy | |
Mitchell | Seeing double | |
Hostomsky | Gene manipulations and classical genetics. | |
ATE288501T1 (de) | Kartierung von genen basierend auf transkription |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |