DE69232413D1 - Verfahren und Vorrichtung zum automatischen Test biologischer Proben - Google Patents

Verfahren und Vorrichtung zum automatischen Test biologischer Proben

Info

Publication number
DE69232413D1
DE69232413D1 DE69232413T DE69232413T DE69232413D1 DE 69232413 D1 DE69232413 D1 DE 69232413D1 DE 69232413 T DE69232413 T DE 69232413T DE 69232413 T DE69232413 T DE 69232413T DE 69232413 D1 DE69232413 D1 DE 69232413D1
Authority
DE
Germany
Prior art keywords
biological samples
automatic testing
testing
automatic
biological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69232413T
Other languages
English (en)
Other versions
DE69232413T2 (de
Inventor
James W Bacus
James V Bacus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Analysis Systems Inc
Original Assignee
Cell Analysis Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Analysis Systems Inc filed Critical Cell Analysis Systems Inc
Application granted granted Critical
Publication of DE69232413D1 publication Critical patent/DE69232413D1/de
Publication of DE69232413T2 publication Critical patent/DE69232413T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Closed-Circuit Television Systems (AREA)
DE69232413T 1991-09-23 1992-09-11 Verfahren und Vorrichtung zum automatischen Test biologischer Proben Expired - Lifetime DE69232413T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76433691A 1991-09-23 1991-09-23

Publications (2)

Publication Number Publication Date
DE69232413D1 true DE69232413D1 (de) 2002-03-21
DE69232413T2 DE69232413T2 (de) 2002-10-10

Family

ID=25070423

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69232413T Expired - Lifetime DE69232413T2 (de) 1991-09-23 1992-09-11 Verfahren und Vorrichtung zum automatischen Test biologischer Proben

Country Status (5)

Country Link
US (1) US5473706A (de)
EP (1) EP0534247B1 (de)
JP (1) JPH0662406A (de)
CA (1) CA2077781A1 (de)
DE (1) DE69232413T2 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
EP0731951B1 (de) * 1993-02-26 2000-07-05 E-Y Laboratories, Inc. Optisches probe-analysesystem und verfahren
US5522255A (en) 1993-08-31 1996-06-04 Boehringer Mannheim Corporation Fluid dose, flow and coagulation sensor for medical instrument
WO1995007050A2 (en) * 1993-08-31 1995-03-16 Boehringer Mannheim Corporation Power supply control for medical instrument
DE69614449T2 (de) * 1995-05-31 2002-05-16 Horiba Ltd Verfahren zur Messung der mikrobiellen Aktivität
US5619428A (en) * 1995-05-31 1997-04-08 Neopath, Inc. Method and apparatus for integrating an automated system to a laboratory
EP0839336A1 (de) * 1995-07-19 1998-05-06 Morphometrix Technologies Inc. Automatische abtastung von mikroskopobjektträgern
US6215892B1 (en) 1995-11-30 2001-04-10 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US6718053B1 (en) 1996-11-27 2004-04-06 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US6151405A (en) * 1996-11-27 2000-11-21 Chromavision Medical Systems, Inc. System and method for cellular specimen grading
US5818637A (en) * 1996-02-26 1998-10-06 Hoover; Rex A. Computerized video microscopy system
US6404906B2 (en) * 1997-03-03 2002-06-11 Bacus Research Laboratories,Inc. Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope
US6272235B1 (en) 1997-03-03 2001-08-07 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
US6396941B1 (en) 1996-08-23 2002-05-28 Bacus Research Laboratories, Inc. Method and apparatus for internet, intranet, and local viewing of virtual microscope slides
US6031930A (en) * 1996-08-23 2000-02-29 Bacus Research Laboratories, Inc. Method and apparatus for testing a progression of neoplasia including cancer chemoprevention testing
US5836877A (en) * 1997-02-24 1998-11-17 Lucid Inc System for facilitating pathological examination of a lesion in tissue
US6189084B1 (en) * 1997-07-14 2001-02-13 Horiba, Ltd. Debugging method and monitoring method for analysis instruments
US6381355B1 (en) * 1997-08-19 2002-04-30 The Hong Kong University Of Science And Technology Inspection method for comparison of articles
US6181811B1 (en) 1998-01-13 2001-01-30 Neopath, Inc. Method and apparatus for optimizing biological and cytological specimen screening and diagnosis
RU2241756C2 (ru) * 1998-02-03 2004-12-10 Хакудзу Инститьют Фор Хелт Сайенс Ко., Лтд. Способ исследования микробов и установка для его осуществления
EP1060455A4 (de) * 1998-02-10 2002-08-07 Ey Lab Inc Reflektometersystem mit kompensation fur die topographie des probenhalters und mit synchroner eliminierung des systembedingten rauschens
AU762085B2 (en) 1999-04-13 2003-06-19 Chromavision Medical Systems, Inc. Histological reconstruction and automated image analysis
US6348325B1 (en) 1999-10-29 2002-02-19 Cytyc Corporation Cytological stain composition
US6661501B1 (en) 1999-10-29 2003-12-09 Cytyc Corporation Cytological stain composition including verification characteristic
US6593102B2 (en) 1999-10-29 2003-07-15 Cytyc Corporation Cytological stain composition
US7369304B2 (en) * 1999-10-29 2008-05-06 Cytyc Corporation Cytological autofocusing imaging systems and methods
US6665060B1 (en) 1999-10-29 2003-12-16 Cytyc Corporation Cytological imaging system and method
JP5087192B2 (ja) 1999-11-30 2012-11-28 インテレクソン コーポレイション 細胞群内の特定細胞に選択的に照準付けする方法及び装置
CA2426871A1 (en) 2000-10-24 2002-05-16 Oncosis Llc Method and device for selectively targeting cells within a three -dimensional specimen
US6985616B2 (en) 2001-10-18 2006-01-10 Robodesign International, Inc. Automated verification and inspection device for sequentially inspecting microscopic crystals
US6466690C1 (en) * 2000-12-19 2008-11-18 Bacus Res Lab Inc Method and apparatus for processing an image of a tissue sample microarray
US7155049B2 (en) * 2001-01-11 2006-12-26 Trestle Acquisition Corp. System for creating microscopic digital montage images
US6993169B2 (en) * 2001-01-11 2006-01-31 Trestle Corporation System and method for finding regions of interest for microscopic digital montage imaging
US6798571B2 (en) 2001-01-11 2004-09-28 Interscope Technologies, Inc. System for microscopic digital montage imaging using a pulse light illumination system
US6816606B2 (en) 2001-02-21 2004-11-09 Interscope Technologies, Inc. Method for maintaining high-quality focus during high-throughput, microscopic digital montage imaging
US7133543B2 (en) * 2001-06-12 2006-11-07 Applied Imaging Corporation Automated scanning method for pathology samples
WO2003042788A2 (en) 2001-11-13 2003-05-22 Chromavision Medical Systems, Inc. A system for tracking biological samples
JP4497923B2 (ja) * 2001-12-05 2010-07-07 ザ ジェイ． デビッド グラッドストーン インスティテューツ ロボット顕微鏡検査システム
CA2436043C (en) * 2002-02-22 2006-01-10 Bacus Research Laboratories, Inc. Focusable virtual microscopy apparatus and method
US7272252B2 (en) 2002-06-12 2007-09-18 Clarient, Inc. Automated system for combining bright field and fluorescent microscopy
US8712118B2 (en) * 2003-04-10 2014-04-29 Carl Zeiss Microimaging Gmbh Automated measurement of concentration and/or amount in a biological sample
US20040202357A1 (en) 2003-04-11 2004-10-14 Perz Cynthia B. Silhouette image acquisition
EP1680757A4 (de) * 2003-10-08 2006-11-22 Lifespan Biosciences Inc Automatisierte mikroskop-objektträger-gewebeproben-abbildung und bilderfassung
US7425426B2 (en) 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
CA2998199A1 (en) 2004-06-01 2005-12-15 Kwalata Trading Limited Methods for use with stem cells involving culturing on a surface with antibodies
US7653260B2 (en) 2004-06-17 2010-01-26 Carl Zeis MicroImaging GmbH System and method of registering field of view
US8582924B2 (en) 2004-06-30 2013-11-12 Carl Zeiss Microimaging Gmbh Data structure of an image storage and retrieval system
US7792338B2 (en) * 2004-08-16 2010-09-07 Olympus America Inc. Method and apparatus of mechanical stage positioning in virtual microscopy image capture
US7495751B2 (en) * 2004-09-30 2009-02-24 Arkray, Inc. Measuring apparatus
JP2008545427A (ja) * 2005-06-02 2008-12-18 インモーション インベストメント，リミティド 自動細胞治療システム
US20070031043A1 (en) 2005-08-02 2007-02-08 Perz Cynthia B System for and method of intelligently directed segmentation analysis for automated microscope systems
US20070091109A1 (en) 2005-09-13 2007-04-26 Roscoe Atkinson Image quality
US7864996B2 (en) * 2006-02-17 2011-01-04 Lucid, Inc. System for macroscopic and confocal imaging of tissue
HUP0600177A2 (en) * 2006-03-03 2009-03-02 3D Histech Kft Equipment for and method of digitizing slides by automated digital image recording system
TW200734462A (en) 2006-03-08 2007-09-16 In Motion Invest Ltd Regulating stem cells
US20080318314A1 (en) * 2007-06-20 2008-12-25 Valentin Fulga Production from blood of cells of neural lineage
WO2009106081A1 (en) 2008-02-29 2009-09-03 Dako Denmark A/S Systems and methods for tracking and providing workflow information
US8934994B1 (en) 2008-07-30 2015-01-13 Rusty S. Lee Method and apparatus for automated fabrication
JP5208825B2 (ja) * 2008-09-12 2013-06-12 オリンパス株式会社 光学顕微鏡
KR20110108390A (ko) 2009-01-12 2011-10-05 신텔렉트 인코포레이티드 레이저로 매개된 박막 절개 및 세포 군체의 이동
WO2010085632A2 (en) * 2009-01-23 2010-07-29 University Of Washington Virtual core flow cytometry
CA2755164C (en) 2009-03-11 2014-02-25 Sensovation Ag Autofocus method and autofocus device
JP5591007B2 (ja) * 2009-11-20 2014-09-17 オリンパス株式会社 顕微鏡装置
AP3556A (en) 2010-02-10 2016-01-18 Kickstart International Inc Human-powered irrigation pump
WO2011151820A2 (en) * 2010-06-01 2011-12-08 Vbact Ltd. Method and system for the detection of biological objects
US10139613B2 (en) 2010-08-20 2018-11-27 Sakura Finetek U.S.A., Inc. Digital microscope and method of sensing an image of a tissue sample
US20120108461A1 (en) 2010-11-01 2012-05-03 Nanolnk, Inc. High-throughput slide processing apparatus
US20120252038A1 (en) * 2011-04-01 2012-10-04 Chianese David A Steroid receptor assays
TWI431264B (zh) * 2011-10-20 2014-03-21 Lite On It Corp 光學偵測裝置及光學量測系統
WO2014093838A2 (en) 2012-12-14 2014-06-19 The J. David Gladstone Institutes Automated robotic microscopy systems
DE102013103971A1 (de) 2013-04-19 2014-11-06 Sensovation Ag Verfahren zum Erzeugen eines aus mehreren Teilbildern zusammengesetzten Gesamtbilds eines Objekts
JP6161399B2 (ja) * 2013-05-17 2017-07-12 オリンパス株式会社 顕微鏡システム
US10007102B2 (en) 2013-12-23 2018-06-26 Sakura Finetek U.S.A., Inc. Microscope with slide clamping assembly
US20150286887A1 (en) 2014-04-07 2015-10-08 Massachusetts Institute Of Technology Use of Microparticle Additives to Simultaneously Enable Artifact-Free Image Registration, Auto-Focusing, and Chromatic Aberration Correction in Microscopy
WO2016179286A1 (en) 2015-05-05 2016-11-10 Massachusetts Institute Of Technology Substrate pre-scanning for high throughput microscopy
US11280803B2 (en) 2016-11-22 2022-03-22 Sakura Finetek U.S.A., Inc. Slide management system
WO2018130573A1 (en) 2017-01-13 2018-07-19 Ventana Medical Systems, Inc. Method of preparing a stage for use in a slide imaging apparatus
CN110168424B (zh) 2017-01-13 2021-10-19 文塔纳医疗系统公司 载片成像设备
WO2019165480A1 (en) 2018-02-26 2019-08-29 Caliber Imaging & Diagnostics, Inc. System and method for macroscopic and microscopic imaging ex-vivo tissue
EP4127811A1 (de) 2020-03-27 2023-02-08 Roche Diagnostics GmbH Objektträgerbildgebungsvorrichtung und verfahren zur bildgebung eines objektträgers
CN115280157A (zh) 2020-03-27 2022-11-01 豪夫迈·罗氏有限公司 载玻片成像设备及用于对载玻片进行成像的方法
WO2023213864A1 (en) 2022-05-04 2023-11-09 F. Hoffmann-La Roche Ag Slide imaging apparatus

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3805028A (en) * 1969-06-23 1974-04-16 Bausch & Lomb Methods of and apparatus for determining the quantity and physical parameters of objects
US3833796A (en) * 1971-10-13 1974-09-03 Georgia Tech Res Inst Method and apparatus for chromosome digitizing
US3851972A (en) * 1973-10-18 1974-12-03 Coulter Electronics Automatic method and system for analysis and review of a plurality of stored slides
US4122518A (en) * 1976-05-17 1978-10-24 The United States Of America As Represented By The Administrator Of The National Aeronautics & Space Administration Automated clinical system for chromosome analysis
US4175860A (en) * 1977-05-31 1979-11-27 Rush-Presbyterian-St. Luke's Medical Center Dual resolution method and apparatus for use in automated classification of pap smear and other samples
JPS5661650A (en) * 1979-10-24 1981-05-27 Omron Tateisi Electronics Co Analyzing device of cell
JPS5672845A (en) * 1979-11-19 1981-06-17 Hitachi Ltd Detecting apparatus of examination position of sample
US4702595A (en) * 1980-10-15 1987-10-27 Smithkline Beckman Corporation Pattern recognition system with working area detection
US4453807A (en) * 1981-06-17 1984-06-12 Smithkline Beckman Corp System for handling slides
DE3306559A1 (de) * 1983-02-25 1984-08-30 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von polyurethan-praepolymeren mit endstaendigen isocyanatgruppen und vermindertem restmonomergehalt
US4519087A (en) * 1983-06-20 1985-05-21 International Remote Imaging Systems, Inc. Method of determining the diagnostic significance of the content of a volume of biological sample containing particles
JPS60211577A (ja) * 1984-04-05 1985-10-23 Hitachi Ltd 白血球分類装置
US5134662A (en) * 1985-11-04 1992-07-28 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
US5016283A (en) * 1985-11-04 1991-05-14 Cell Analysis Systems, Inc. Methods and apparatus for immunoploidy analysis
US5086476A (en) * 1985-11-04 1992-02-04 Cell Analysis Systems, Inc. Method and apparatus for determining a proliferation index of a cell sample
US5008185A (en) * 1985-11-04 1991-04-16 Cell Analysis Systems, Inc. Methods and apparatus for the quantitation of nuclear proteins
US4741043B1 (en) * 1985-11-04 1994-08-09 Cell Analysis Systems Inc Method of and apparatus for image analyses of biological specimens
US4998284A (en) * 1987-11-17 1991-03-05 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
JPH0652263B2 (ja) * 1985-12-10 1994-07-06 株式会社日立製作所 細胞分析装置
JPH0746112B2 (ja) * 1986-04-09 1995-05-17 株式会社日立製作所 細胞分析方法
US4836667A (en) * 1986-05-06 1989-06-06 Slidex Corporation Microscope
JPH01124751A (ja) * 1987-11-10 1989-05-17 Konica Corp 変換式の作成方法
EP0353589B1 (de) * 1988-08-02 1996-02-07 Abbott Laboratories Verfahren und Vorrichtung zum Erzeugen von Eichdaten für die Analyse
DE3836716A1 (de) * 1988-10-28 1990-05-03 Zeiss Carl Fa Verfahren zur auswertung von zellbildern
US5107422A (en) * 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
AU6870391A (en) * 1989-10-23 1991-05-31 Neuromedical Systems, Inc. Automated cytological specimen classification system and method
US5000554A (en) * 1990-05-23 1991-03-19 Gibbs David L Method and apparatus for use in microscope investigations with a carrier having exactly one x-y coordinate system reference mark
US5109929A (en) * 1990-09-07 1992-05-05 Spears Manufacturing Corp. Sprinkler head adapter

Also Published As

Publication number Publication date
EP0534247B1 (de) 2002-02-13
DE69232413T2 (de) 2002-10-10
EP0534247A2 (de) 1993-03-31
US5473706A (en) 1995-12-05
JPH0662406A (ja) 1994-03-04
CA2077781A1 (en) 1993-03-24
EP0534247A3 (en) 1995-02-15

Similar Documents

Publication Publication Date Title
DE69232413T2 (de) Verfahren und Vorrichtung zum automatischen Test biologischer Proben
DE69329280D1 (de) Testvorrichtung und verfahren zur durchführung von blutgerinnungstests
DE3855018T2 (de) Verfahren und Vorrichtung zur automatischen Analyse von Proben
DE68917399T2 (de) Testvorrichtung und Verfahren zur Protein-Untersuchung.
DE69531475D1 (de) Vorrichtung und Verfahren zur automatischen Analyse einer Probe
DE69226480D1 (de) Vorrichtung und Verfahren zur Beleuchtung einer Probe
DE69213531T2 (de) Verfahren und Vorrichtung zum Beobachten einer biologischen Probe
DE69025158T2 (de) Verfahren und Vorrichtung zum analogen Testen von Dünnfilmtransistor-Matrizen
DE69711338T2 (de) Verfahren und Vorrichtung zur automatischen Analyse von Probenlösungen
DE69033130D1 (de) Verfahren und Gerät zur Prüfung von Substraten
DE69030832D1 (de) Automatische Analysevorrichtung und Verfahren für klinische Untersuchung
DE58906917D1 (de) Vorrichtung und Verfahren zur Leckprüfung.
DE69429230D1 (de) Vorrichtung und verfahren zur automatischen prüfung von proben
DE69319843D1 (de) Verfahren und Apparat zum Nachweis biologischer Aktivitäten in einer Probe
DE68914411T2 (de) Vorrichtung und Verfahren zum Testen einer flüssigen Probe.
DE3888083T2 (de) Verfahren und Apparat zur rheologischen Prüfung.
DE69017029T2 (de) Verfahren und vorrichtung zur nichtzerstörenden prüfung.
DE69026541D1 (de) Verfahren und Vorrichtung zur Analyse fester Proben
DE58909849D1 (de) Verfahren und Vorrichtung zur Quecksilberanalyse
DE69229933D1 (de) Einrichtung und Verfahren zur zerstörungsfreien Prüfung für supraleitende Materialien
DE69017104T2 (de) Verfahren und Vorrichtung zur Prüfung einer Lambda-Sonde.
DE69025812D1 (de) Verfahren und Gerät zur automatischen Durchführung von Prüfmustererzeugung
DE69629536D1 (de) Verfahren und Vorrichtung zur Massenanalyse einer gelösten Probe
DE59604203D1 (de) Verfahren und Vorrichtung zum vollautomatischen Handhaben von elektrisch zu prüfenden Prüflingen
DE69217703T2 (de) Verfahren und Vorrichtung zum Analysieren von Probenlösungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition