DE69232859T2 - Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptiden - Google Patents
Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptidenInfo
- Publication number
- DE69232859T2 DE69232859T2 DE69232859T DE69232859T DE69232859T2 DE 69232859 T2 DE69232859 T2 DE 69232859T2 DE 69232859 T DE69232859 T DE 69232859T DE 69232859 T DE69232859 T DE 69232859T DE 69232859 T2 DE69232859 T2 DE 69232859T2
- Authority
- DE
- Germany
- Prior art keywords
- composition
- virus polypeptides
- several immune
- immune reactive
- reactive hepatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 241000711549 Hepacivirus C Species 0.000 title 1
- 208000010710 hepatitis C virus infection Diseases 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/82—Hepatitis associated antigens and antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/826—Viruses
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75957591A | 1991-09-13 | 1991-09-13 | |
PCT/US1992/007683 WO1993006126A1 (en) | 1991-09-13 | 1992-09-11 | Immunoreactive hepatitis c virus polypeptide compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69232859D1 DE69232859D1 (de) | 2003-01-16 |
DE69232859T2 true DE69232859T2 (de) | 2003-04-10 |
Family
ID=25056174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232859T Expired - Lifetime DE69232859T2 (de) | 1991-09-13 | 1992-09-11 | Zusammensetzung aus mehreren immunreaktiven hepatitis-c-virus-polypeptiden |
Country Status (16)
Country | Link |
---|---|
US (6) | US5756312A (de) |
EP (1) | EP0608261B1 (de) |
JP (5) | JPH06511149A (de) |
AT (1) | ATE228564T1 (de) |
AU (1) | AU679429B2 (de) |
BG (1) | BG62973B1 (de) |
CA (1) | CA2116764C (de) |
DE (1) | DE69232859T2 (de) |
DK (1) | DK0608261T3 (de) |
ES (1) | ES2182822T3 (de) |
FI (1) | FI112438B (de) |
HU (1) | HU227510B1 (de) |
PL (2) | PL171489B1 (de) |
RO (1) | RO116199B1 (de) |
RU (2) | RU2136311C1 (de) |
WO (1) | WO1993006126A1 (de) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6596476B1 (en) * | 1989-12-22 | 2003-07-22 | Abbott Laboratories | Hepatitis C assay |
CA2116764C (en) * | 1991-09-13 | 1999-12-07 | Amy J. Weiner | Immunoreactive hepatitis c virus polypeptide compositions |
US6297048B1 (en) * | 1992-02-04 | 2001-10-02 | Chiron Corporation | Hepatitis therapeutics |
US6709828B1 (en) | 1992-03-06 | 2004-03-23 | N.V. Innogenetics S.A. | Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them |
US6667387B1 (en) | 1996-09-30 | 2003-12-23 | N.V. Innogenetics S.A. | HCV core peptides |
CA2142007C (en) * | 1992-08-11 | 2007-10-30 | Robert Glen Urban | Immunomodulatory peptides |
EP1004670B1 (de) | 1993-04-27 | 2012-04-11 | Innogenetics N.V. | Hepatitis C Virus Genotypsequenzen sowie ihre Verwendung als Behandlungs- und Nachweismittel |
US7255997B1 (en) | 1993-04-27 | 2007-08-14 | N.V. Innogenetics S.A. | Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents |
DE69433160T2 (de) | 1993-05-12 | 2004-07-08 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Konserviertes Motiv der Hepatitis C Virus E2/NS1 Region |
US5514539A (en) * | 1993-06-29 | 1996-05-07 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines |
EP0992581B2 (de) | 1993-11-04 | 2011-05-25 | Innogenetics N.V. | Immunodominante menschliche T-Zell Epitope des Hepatitis C Virus |
DE59511054D1 (de) | 1994-07-25 | 2006-08-10 | Roche Diagnostics Gmbh | Bestimmung von spezifischem immunglobulin unter verwendung multipler antigene |
SG71728A1 (en) | 1994-07-29 | 2000-04-18 | Innogenetics Nv | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
JPH10507643A (ja) | 1994-10-21 | 1998-07-28 | イノジェネティックス・ナムローゼ・フェンノートシャップ | C型肝炎ウイルス遺伝子型の新規配列、ならびにそれらの予防薬、治療薬および診断薬としての使用 |
US6110465A (en) * | 1995-06-07 | 2000-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines |
US6127116A (en) | 1995-08-29 | 2000-10-03 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
US7235394B1 (en) | 1995-08-29 | 2007-06-26 | Washington University | Functional DNA clone for hepatitis C virus (HCV) and uses thereof |
US7045363B2 (en) * | 1996-05-01 | 2006-05-16 | Fujirebio Inc. | Nucleic acid-bound polypeptide method of producing nucleic acid-bound polypeptide and immunoassay using the polypeptide |
US6001613A (en) * | 1996-05-24 | 1999-12-14 | Board Of Regents Of University Of Nebraska | Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid |
CA2269097C (en) | 1996-11-08 | 2007-01-09 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Synthesis and purification of hepatitis c virus-like particles |
US6322965B1 (en) * | 1997-02-10 | 2001-11-27 | Advanced Life Science Institute, Inc. | Chimera antigen peptide |
US7338759B1 (en) | 1997-03-04 | 2008-03-04 | Washington University | HCV variants |
US7049428B1 (en) * | 1998-03-04 | 2006-05-23 | Washington University | HCV variants |
ATE482974T1 (de) * | 1997-11-06 | 2010-10-15 | Innogenetics Nv | Multimere peptide, die auf dem hepatitis c virus hüllprotein basieren, für diagnostische verwendung und für impfzwecke |
US6683058B1 (en) | 1998-04-15 | 2004-01-27 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
US6451306B1 (en) | 1998-04-15 | 2002-09-17 | The Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
US7157435B2 (en) | 1998-04-15 | 2007-01-02 | The Regents Of The University Of California | Methods for modulation of the effects of aging on the primate brain |
US6815431B2 (en) | 1998-04-15 | 2004-11-09 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
US7052830B1 (en) | 1998-06-09 | 2006-05-30 | Branch Andrea D | Hepatitis C virus peptides and uses thereof |
US7108855B2 (en) * | 1998-06-24 | 2006-09-19 | Innogenetics N.V. | Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use |
US6548634B1 (en) * | 1998-09-30 | 2003-04-15 | Chiron Corporation | Synthetic peptides having FGF receptor affinity |
US20030180284A1 (en) * | 1998-11-05 | 2003-09-25 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes |
US7091324B2 (en) | 1998-11-05 | 2006-08-15 | Board Of Trustees Of Leland Stanford Junior University | Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes |
CA2358385C (en) * | 1998-12-31 | 2013-08-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
AU2221600A (en) * | 1998-12-31 | 2000-07-31 | Chiron Corporation | Improved expression of hiv polypeptides and production of virus-like particles |
US7935805B1 (en) * | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
US20030194800A1 (en) * | 2001-08-31 | 2003-10-16 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
WO2000039303A2 (en) | 1998-12-31 | 2000-07-06 | Chiron Corporation | Modified hiv env polypeptides |
EP1535628B1 (de) * | 1999-11-24 | 2013-07-31 | Novartis Vaccines and Diagnostics, Inc. | Hbv/hcv virus-ähnliche teilchen |
US6740323B1 (en) | 1999-11-24 | 2004-05-25 | Chiron Corporation | HBV/HCV virus-like particle |
NZ524070A (en) * | 2000-07-19 | 2008-05-30 | Univ California | Methods for therapy of neurodegenerative disease of the non-human brain |
US6680059B2 (en) * | 2000-08-29 | 2004-01-20 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
US7022830B2 (en) * | 2000-08-17 | 2006-04-04 | Tripep Ab | Hepatitis C virus codon optimized non-structural NS3/4A fusion gene |
US6858590B2 (en) * | 2000-08-17 | 2005-02-22 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
WO2002013855A2 (en) | 2000-08-17 | 2002-02-21 | Tripep Ab | Vaccines containing ribavirin and methods of use thereof |
WO2002022155A1 (en) | 2000-09-13 | 2002-03-21 | Hawaii Biotechnology Group, Inc. | Immunogenic composition of hepatitis c and methods of use thereof |
CA2634992C (en) | 2001-07-05 | 2012-10-16 | Novartis Vaccines And Diagnostics, Inc. | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
US20030198621A1 (en) * | 2001-07-05 | 2003-10-23 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof |
US20030170614A1 (en) * | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
AR045702A1 (es) * | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
WO2005007808A2 (en) | 2003-05-15 | 2005-01-27 | Chiron Corporation | Hiv polynucleotides and polypeptides derived from botswana mj4 |
US20050202036A1 (en) * | 2003-07-22 | 2005-09-15 | Branch Andrea D. | Alternate reading frame polypeptides drived from hepatitis C and methods of their use |
US20050130131A1 (en) * | 2003-08-14 | 2005-06-16 | California Institute Of Molecular Medicine | Method for isolation and replication of infectious human hepatitis-C virus |
US8124747B2 (en) | 2003-08-29 | 2012-02-28 | Innogenetics | HCV clade and prototype sequences thereof |
CA2585672A1 (en) | 2004-11-01 | 2006-05-11 | Novartis Vaccines And Diagnostics Inc. | Combination approaches for generating immune responses |
CA2618429A1 (en) * | 2005-05-25 | 2007-03-22 | Tripep Ab | A hepatitis c virus non-structural ns3/4a fusion gene |
WO2007084568A2 (en) | 2006-01-17 | 2007-07-26 | Health Research, Inc. | Heteroduplex tracking assay |
EP2185195A2 (de) * | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen-plattform |
EP2201023A2 (de) * | 2007-09-14 | 2010-06-30 | GENimmune N.V. | Affinitäts-tag |
US8268783B2 (en) | 2007-09-28 | 2012-09-18 | Portola Pharmaceuticals, Inc. | Antidotes for factor Xa inhibitors and methods of using the same |
ES2796623T3 (es) | 2007-09-28 | 2020-11-27 | Portola Pharm Inc | Antídotos para inhibidores del factor Xa y procedimientos de uso de los mismos |
WO2009130588A2 (en) * | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
US20100104555A1 (en) * | 2008-10-24 | 2010-04-29 | The Scripps Research Institute | HCV neutralizing epitopes |
WO2010148117A1 (en) | 2009-06-17 | 2010-12-23 | Scantibodies Laboratory, Inc. | Therapeutic and diagnostic affinity purified specific polyclonal antibodies |
CN102625712B (zh) | 2009-07-15 | 2017-07-25 | 博尔托拉制药公司 | 用于因子xa抑制剂的解毒剂的单位剂量制剂及其使用方法 |
SG10201605500TA (en) | 2011-07-06 | 2016-08-30 | Novartis Ag | Cationic oil-in-water emulsions |
MX350198B (es) | 2011-07-06 | 2017-08-30 | Novartis Ag | Emulsiones aceite en agua que contienen acidos nucleicos. |
US8609355B2 (en) | 2011-07-26 | 2013-12-17 | Indicator Systems International, Inc. | Assays for the detection of microbes |
FR2984328B1 (fr) | 2011-12-20 | 2016-12-30 | Bio-Rad Innovations | Procede de detection d'une infection par le virus de l'hepatite c |
US9228006B2 (en) | 2012-03-16 | 2016-01-05 | University Health Network | Methods and compositions for modulating Toso activity |
RU2520710C1 (ru) * | 2012-12-10 | 2014-06-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Челябинская государственная медицинская академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ЧелГМА Минздравсоцразвития России) | Способ прогнозирования персистенции онкогенных типов вируса папилломы человека в цервикальном эпителии |
US20150250853A1 (en) | 2014-03-07 | 2015-09-10 | University Health Network | Methods and compositions for modifying the immune response |
RU2675108C2 (ru) * | 2015-06-15 | 2018-12-17 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича" (ИБМХ) | Композиция на основе синтетических пептидов и липидов для вакцины против гепатита с |
US10287338B2 (en) | 2015-07-10 | 2019-05-14 | Miran NERSISSIAN | Factor VIII protein compositions and methods of treating of hemophilia A |
WO2017066719A2 (en) | 2015-10-14 | 2017-04-20 | Research Institute At Nationwide Children's Hospital | Hu specific interfering agents |
AU2018206560A1 (en) | 2017-01-04 | 2019-07-18 | Research Institute At Nationwide Children's Hospital | Antibody fragments for the treatment of biofilm-related disorders |
EP3565589A1 (de) | 2017-01-04 | 2019-11-13 | Research Institute at Nationwide Children's Hospital | Dnabii-impfstoffe und antikörper mit erhöhter aktivität |
WO2018170178A1 (en) | 2017-03-15 | 2018-09-20 | Research Institute At Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
AU2020311897A1 (en) | 2019-07-08 | 2022-02-03 | Research Institute At Nationwide Children's Hospital | Antibody compositions for disrupting biofilms |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3400079A1 (de) * | 1984-01-03 | 1985-07-11 | Röhm GmbH, 6100 Darmstadt | Wasserspreitendes kunststoffmaterial, verfahren zu seiner herstellung u. verwendung als verglasungs- und bedachungsmaterial |
NZ219516A (en) * | 1987-02-10 | 1991-02-26 | Wellcome Found | Fusion proteins of hbcag (hepatitis b virus core antigen) |
US5350671A (en) * | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
NZ227011A (en) * | 1987-11-18 | 1992-03-26 | Chiron Corp | Non-a, non-b-hepatitis (hepatitis c) antigens, proteins, nucleotide sequences, vaccines and kits |
UA50829C2 (uk) * | 1989-03-17 | 2002-11-15 | Чірон Корпорейшн | Очищений поліпептид, що містить антиген вірусу гепатиту с, полінуклеотид, вектор, клітини, система експресії, моноклональне антитіло, препарат поліклональних антитіл, нуклеотидна проба, аналітичні набори, спосіб виявлення нуклеїнових кислот, способи імуноаналізу, вакцина, спосіб одержання антитіл |
ATE211772T1 (de) * | 1989-05-18 | 2002-01-15 | Chiron Corp | Nanbv-diagnostika: polynukleotide, geeignet für reihenuntersuchungen auf hepatitis c-virus |
US5372928A (en) * | 1989-09-15 | 1994-12-13 | Chiron Corporation | Hepatitis C virus isolates |
CA2065287C (en) * | 1989-09-15 | 1999-12-21 | Tatsuo Miyamura | New hcv isolates |
DE59109271D1 (de) * | 1990-11-03 | 2006-04-27 | Dade Behring Marburg Gmbh | HCV-spezifische Peptide, Mittel dazu und ihre Verwendung |
CA2116764C (en) * | 1991-09-13 | 1999-12-07 | Amy J. Weiner | Immunoreactive hepatitis c virus polypeptide compositions |
-
1992
- 1992-09-11 CA CA002116764A patent/CA2116764C/en not_active Expired - Lifetime
- 1992-09-11 JP JP5506119A patent/JPH06511149A/ja not_active Withdrawn
- 1992-09-11 HU HU9400741A patent/HU227510B1/hu unknown
- 1992-09-11 RO RO94-00391A patent/RO116199B1/ro unknown
- 1992-09-11 EP EP92919917A patent/EP0608261B1/de not_active Expired - Lifetime
- 1992-09-11 RU RU94024561A patent/RU2136311C1/ru active
- 1992-09-11 PL PL92302729A patent/PL171489B1/pl unknown
- 1992-09-11 DE DE69232859T patent/DE69232859T2/de not_active Expired - Lifetime
- 1992-09-11 ES ES92919917T patent/ES2182822T3/es not_active Expired - Lifetime
- 1992-09-11 DK DK92919917T patent/DK0608261T3/da active
- 1992-09-11 RU RU98117084/14A patent/RU2212899C2/ru active
- 1992-09-11 AT AT92919917T patent/ATE228564T1/de active
- 1992-09-11 PL PL92313797A patent/PL171972B1/pl unknown
- 1992-09-11 AU AU26436/92A patent/AU679429B2/en not_active Expired
- 1992-09-11 WO PCT/US1992/007683 patent/WO1993006126A1/en active IP Right Grant
-
1994
- 1994-03-11 BG BG98653A patent/BG62973B1/bg unknown
- 1994-03-14 FI FI941199A patent/FI112438B/fi not_active IP Right Cessation
- 1994-04-19 US US08/231,368 patent/US5756312A/en not_active Expired - Lifetime
-
1995
- 1995-05-12 US US08/440,210 patent/US5766845A/en not_active Expired - Lifetime
- 1995-05-12 US US08/440,103 patent/US5670152A/en not_active Expired - Lifetime
- 1995-05-12 US US08/440,542 patent/US5670153A/en not_active Expired - Lifetime
- 1995-06-06 US US08/471,498 patent/US5728520A/en not_active Expired - Lifetime
-
1998
- 1998-03-24 US US09/046,604 patent/US6303292B1/en not_active Expired - Fee Related
-
2001
- 2001-07-11 JP JP2001211447A patent/JP2002167336A/ja not_active Withdrawn
-
2003
- 2003-09-18 JP JP2003326811A patent/JP2004073207A/ja not_active Withdrawn
-
2005
- 2005-01-27 JP JP2005020454A patent/JP4353905B2/ja not_active Expired - Lifetime
-
2008
- 2008-02-20 JP JP2008038799A patent/JP2008133301A/ja not_active Withdrawn
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