DE69301311T2 - Selbst-agglomerierendes diketopiperazin-arzneistoffabgabesystem - Google Patents

Selbst-agglomerierendes diketopiperazin-arzneistoffabgabesystem

Info

Publication number
DE69301311T2
DE69301311T2 DE69301311T DE69301311T DE69301311T2 DE 69301311 T2 DE69301311 T2 DE 69301311T2 DE 69301311 T DE69301311 T DE 69301311T DE 69301311 T DE69301311 T DE 69301311T DE 69301311 T2 DE69301311 T2 DE 69301311T2
Authority
DE
Germany
Prior art keywords
microparticles
drug delivery
diketopiperazine
stable
agglomerating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69301311T
Other languages
English (en)
Other versions
DE69301311D1 (de
Inventor
Robert Feldstein
John Glass
Solomon S Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mannkind Corp
Original Assignee
Pharmaceutical Discovery Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmaceutical Discovery Corp filed Critical Pharmaceutical Discovery Corp
Publication of DE69301311D1 publication Critical patent/DE69301311D1/de
Application granted granted Critical
Publication of DE69301311T2 publication Critical patent/DE69301311T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
DE69301311T 1992-03-11 1993-03-11 Selbst-agglomerierendes diketopiperazin-arzneistoffabgabesystem Expired - Lifetime DE69301311T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/849,186 US5352461A (en) 1992-03-11 1992-03-11 Self assembling diketopiperazine drug delivery system
PCT/US1993/002245 WO1993018754A1 (en) 1992-03-11 1993-03-11 Self-assembling diketopiperazine drug delivery system

Publications (2)

Publication Number Publication Date
DE69301311D1 DE69301311D1 (de) 1996-02-22
DE69301311T2 true DE69301311T2 (de) 1996-08-22

Family

ID=25305266

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69301311T Expired - Lifetime DE69301311T2 (de) 1992-03-11 1993-03-11 Selbst-agglomerierendes diketopiperazin-arzneistoffabgabesystem

Country Status (11)

Country Link
US (2) US5352461A (de)
EP (1) EP0630236B1 (de)
JP (1) JP2617273B2 (de)
AT (1) ATE132744T1 (de)
AU (1) AU680408B2 (de)
CA (1) CA2131366C (de)
DE (1) DE69301311T2 (de)
DK (1) DK0630236T3 (de)
ES (1) ES2089844T3 (de)
GR (1) GR3019622T3 (de)
WO (1) WO1993018754A1 (de)

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331318B1 (en) * 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5541155A (en) * 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5443841A (en) 1992-06-15 1995-08-22 Emisphere Technologies, Inc. Proteinoid microspheres and methods for preparation and use thereof
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5693338A (en) * 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US5352461A (en) * 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
US6916489B2 (en) * 1992-06-15 2005-07-12 Emisphere Technologies, Inc. Active agent transport systems
US5811127A (en) 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5401516A (en) 1992-12-21 1995-03-28 Emisphere Technologies, Inc. Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof
US5709861A (en) 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US6461643B2 (en) 1993-04-22 2002-10-08 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
EP1025840B1 (de) 1993-04-22 2005-06-29 Emisphere Technologies, Inc. Orale Dareichungsform
US20010003001A1 (en) 1993-04-22 2001-06-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5958457A (en) 1993-04-22 1999-09-28 Emisphere Technologies, Inc. Compositions for the delivery of antigens
US20010003739A1 (en) * 1993-06-24 2001-06-14 Astrazeneca Ab Systemic administration of a therapeutic preparation
US5830853A (en) 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
US6794357B1 (en) * 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
US5466259A (en) * 1994-03-07 1995-11-14 Durette; Jean-Francois Orbital implant and method
US6165976A (en) 1994-06-23 2000-12-26 Astra Aktiebolag Therapeutic preparation for inhalation
BR9510510A (pt) 1994-12-22 1998-07-07 Astra Ab Formulação em aerossol farmacêutica uso da mesma e processos para fabricação da mesma para tratamento de um paciente carente de terapia
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (pt) 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US6428771B1 (en) * 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
US5824345A (en) * 1995-06-07 1998-10-20 Emisphere Technologies, Inc. Fragrances and flavorants
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
US5667806A (en) 1995-06-07 1997-09-16 Emisphere Technologies, Inc. Spray drying method and apparatus
US6051258A (en) 1995-06-07 2000-04-18 Emisphere Technologies, Inc. Proteinoid emulsions and methods for preparation and use thereof
GB2320248B (en) 1995-09-11 1999-04-14 Emisphere Tech Inc Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones
WO1997017985A1 (en) * 1995-11-13 1997-05-22 Smithkline Beecham Corporation Hemoregulatory compounds
SI9720025A (sl) 1996-03-29 1999-08-31 Emishphere Technologies, Inc. Spojine in sestavki za prenos aktivne snovi
AU3828597A (en) 1996-06-14 1998-01-07 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
WO1998021951A1 (en) 1996-11-18 1998-05-28 Emisphere Technologies, Inc. Methods and compositions for inducing oral tolerance in mammals
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
US5891237A (en) * 1997-10-08 1999-04-06 Millennium Inorganic Chemicals, Ltd. Production of free flowing spheres using partially neutralized fatty acid
WO2000006184A1 (en) 1998-07-27 2000-02-10 Emisphere Technologies, Inc. Pulmonary delivery of active agents
US6440929B1 (en) 1998-07-27 2002-08-27 Emisphere Technologies, Inc. Pulmonary delivery of active agents
US6991798B1 (en) 1998-08-07 2006-01-31 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
JP4430235B2 (ja) * 1998-08-07 2010-03-10 エミスフェアー・テクノロジーズ・インク 活性剤のデリバリーのための化合物及び組成物
BR0008590A (pt) * 1999-01-08 2001-10-30 Emisphere Tech Inc Agente de entrega polimérico, composição, formade unidade de dosagem, método para administrarum agente biologicamente ativo a um animalnecessitando o agente, método para preparar umacomposição; e composto
EP1156812A4 (de) * 1999-02-23 2004-09-29 Isis Pharmaceuticals Inc Multipartikuläre formulierung
WO2000050386A1 (en) 1999-02-26 2000-08-31 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
CA2369591C (en) * 1999-04-05 2011-06-14 Emisphere Technologies, Inc. Disodium salts, monohydrate, and ethanol solvates
PT1808438E (pt) * 1999-06-29 2015-01-14 Mannkind Corp Purificação e estabilização de péptidos e proteínas em agentes farmacêuticos
AU2012201760B2 (en) * 1999-06-29 2015-04-16 Mannkind Corporation Purification and stabilization of peptide and protein pharmaceutical agents
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
ATE427743T1 (de) 1999-11-15 2009-04-15 Biocure Inc Auf aussere bedingungen ansprechende polymere hohle partikel
AU2274201A (en) 1999-12-16 2001-06-25 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US7833549B2 (en) * 2000-01-19 2010-11-16 Mannkind Corporation Dry powder formulations of antihistamine for nasal administration
US6808707B2 (en) 2000-02-04 2004-10-26 Matrix Design Wound healing compositions and methods using tropoelastin and lysyl oxidase
DE10019879A1 (de) * 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
US6537968B1 (en) * 2000-07-24 2003-03-25 Alphamed Pharmaceuticals Corp Treatment of lupus erythematosus
PT1311269E (pt) * 2000-08-04 2012-05-10 Dmi Biosciences Inc Método de utilização de dicetopiperazinas e composição que contém as mesmas
WO2002062797A2 (en) * 2000-12-29 2002-08-15 Celltech R & D, Inc. Pharmaceutical uses and synthesis of diketopiperazines
US20030225300A1 (en) * 2001-04-19 2003-12-04 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US6991779B2 (en) * 2002-01-18 2006-01-31 Mannkind Corporation Compositions for treatment or prevention of bioterrorism
WO2003080149A2 (en) 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
US7053034B2 (en) * 2002-04-10 2006-05-30 Salvona, Llc Targeted controlled delivery compositions activated by changes in pH or salt concentration
AU2003234240A1 (en) * 2002-04-23 2003-11-10 Teva Pharmaceutical Industries Ltd. Pharmaceutical composition containing lamotrigine particles of defined morphology
DE60326709D1 (de) * 2002-04-29 2009-04-30 Supernus Pharmaceuticals Inc Pharmazeutische formulierungen mit verbesserter bioverfügbarkeit
US20080260838A1 (en) * 2003-08-01 2008-10-23 Mannkind Corporation Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
US20040038865A1 (en) * 2002-08-01 2004-02-26 Mannkind Corporation Cell transport compositions and uses thereof
EP1545457A4 (de) * 2002-08-01 2009-07-01 Mannkind Corp Zelltransport-zusammensetzungen und ihre verwendungen
US20040171518A1 (en) * 2003-02-27 2004-09-02 Medtronic Minimed, Inc. Compounds for protein stabilization and methods for their use
US20040224024A1 (en) * 2003-04-23 2004-11-11 Massachusetts Institute Of Technology Controlled drug release formulations containing polyion complexes
EP2537524B1 (de) * 2003-05-15 2016-07-06 Ampio Pharmaceuticals, Inc. Behandlung von T-Zell-vermittelten Krankheiten
KR20060054371A (ko) * 2003-07-31 2006-05-22 쓰리엠 이노베이티브 프로퍼티즈 컴파니 캡슐화 및 제어된 방출을 위한 조성물
US8921311B2 (en) 2003-08-01 2014-12-30 Mannkind Corporation Method for treating hyperglycemia
US7795007B2 (en) 2003-09-23 2010-09-14 Wisconsin Alumni Research Foundation Detection of post-translationally modified peptides with liquid crystals
US8133680B2 (en) * 2003-09-23 2012-03-13 Wisconsin Alumni Research Foundation Using liquid crystals to detect affinity microcontact printed biomolecules
US7338171B2 (en) * 2003-10-27 2008-03-04 Jen-Chuen Hsieh Method and apparatus for visual drive control
US20070027063A1 (en) * 2004-01-12 2007-02-01 Mannkind Corporation Method of preserving the function of insulin-producing cells
EP1708738B1 (de) * 2004-01-12 2016-05-04 MannKind Corporation Verfahren zur verringerung des proinsulinspiegels im serum bei zuckerkranken mit type 2 diabetes
JP2005209106A (ja) * 2004-01-26 2005-08-04 Nec Corp 携帯通信端末、受信メール管理方法、プログラムおよび記録媒体
US20080248999A1 (en) * 2007-04-04 2008-10-09 Biodel Inc. Amylin formulations
US20080096800A1 (en) * 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US20080085298A1 (en) * 2004-03-12 2008-04-10 Biodel, Inc. Rapid Mucosal Gel or Film Insulin Compositions
PT2319500E (pt) * 2004-03-12 2013-01-23 Biodel Inc Composições de distribuição de fármacos de actuação rápida
JP5078014B2 (ja) * 2004-08-20 2012-11-21 マンカインド コーポレイション ジケトピペラジン合成の触媒反応
EP1781254A2 (de) * 2004-08-23 2007-05-09 Mannkind Corporation Pulmonale abgabe von inhibitoren des typs phosphodiesterase-5
HUE026797T2 (en) 2004-08-23 2016-07-28 Mannkind Corp Diceto-piperazine salts for drug delivery
WO2006086107A2 (en) * 2005-01-10 2006-08-17 Mannkind Corporation Methods and compositions for minimizing accrual of inhalable insulin in the lungs
CN101346468B (zh) 2005-06-15 2016-03-30 麻省理工学院 含胺脂质和其用途
US20070004036A1 (en) * 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for keratinocyte culture
US20070128685A1 (en) * 2005-07-01 2007-06-07 Rodolfo Faudoa Methods and compositions for cell culture
US20070003541A1 (en) * 2005-07-01 2007-01-04 Rodolfo Faudoa Methods and compositions for therapeutics
KR20120060245A (ko) 2005-09-14 2012-06-11 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
US20070086952A1 (en) * 2005-09-29 2007-04-19 Biodel, Inc. Rapid Acting and Prolonged Acting Inhalable Insulin Preparations
ATE465087T1 (de) 2005-11-21 2010-05-15 Mannkind Corp Gerät und verfahren zur pulverausgabe und messung
EP2497484A3 (de) * 2006-02-22 2012-11-07 MannKind Corporation Verfahren zur Verbesserung der pharmazeutischen Eigenschaften von Mikropartikeln mit Diketopiperazin und einem Wirkstoff
US7718609B2 (en) 2006-04-12 2010-05-18 Biodel Inc. Rapid acting and long acting insulin combination formulations
EP2010155A2 (de) * 2006-04-14 2009-01-07 MannKind Corporation Pharmazeutische glucagon-ähnliche peptid1-formulierungen
AU2007280995C1 (en) * 2006-08-04 2013-05-23 Manus Pharmaceuticals (Canada) Ltd. Multifunctional bioactive compounds
WO2008054725A2 (en) 2006-10-31 2008-05-08 Surmodics Pharmaceuticals, Inc. Spheronized polymer particles
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
WO2009055740A2 (en) 2007-10-24 2009-04-30 Mannkind Corporation Method of preventing adverse effects by glp-1
KR20100090692A (ko) * 2007-10-24 2010-08-16 맨카인드 코포레이션 활성제의 전달
MX2010007342A (es) * 2008-01-04 2010-08-26 Biodel Inc Formulaciones de insulina para la liberacion de insulina como una funcion de los niveles de glucosa en el tejido.
EP2300011A4 (de) 2008-05-27 2012-06-20 Dmi Life Sciences Inc Therapeutische verfahren und verbindungen
EP3281663B8 (de) 2008-06-13 2022-09-21 MannKind Corporation Atemluftbetriebener trockenpulverinhalator zur verabreichung von medikamenten
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
BRPI0917568A2 (pt) 2008-08-05 2019-09-24 Mannkind Corp módulos distribuidores de pó e montagens distribuidas de pó aperfeiçoados
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
AU2009311667B2 (en) 2008-11-07 2016-04-14 Massachusetts Institute Of Technology Aminoalcohol lipidoids and uses thereof
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
DK2379511T3 (en) * 2008-12-29 2015-01-12 Mannkind Corp Substituted diketopiperazinanaloger for use as pharmaceutical management funds
AU2010203573A1 (en) 2009-01-08 2011-06-30 Mannkind Corporation Method for treating hyperglycemia with GLP-1
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
TWI528982B (zh) 2009-03-04 2016-04-11 曼凱公司 改良的乾粉藥物輸送系統
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
WO2010144789A2 (en) * 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
EP3556356B1 (de) * 2009-06-12 2021-05-05 MannKind Corporation Diketopiperazin-mikropartikel mit definiertem isomergehalt
US8642548B2 (en) 2009-08-07 2014-02-04 Mannkind Corporation Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome
CN104801215B (zh) 2009-11-02 2017-11-17 曼康公司 以沉淀过程产生药物颗粒的反应器
MX357798B (es) 2009-11-02 2018-07-25 Mannkind Corp Aparato y método para la criogranulación de una composición farmacéutica.
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
NZ600616A (en) 2009-12-01 2014-11-28 Shire Human Genetic Therapies Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
US9140651B2 (en) 2010-05-07 2015-09-22 Mannkind Corporation Determining percent solids in suspension using raman spectroscopy
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
WO2012027675A2 (en) 2010-08-26 2012-03-01 Massachusetts Institute Of Technology Poly(beta-amino alcohols), their preparation, and uses thereof
WO2012033792A2 (en) 2010-09-07 2012-03-15 Dmi Acquisition Corp. Treatment of diseases
CN103200940A (zh) 2010-11-09 2013-07-10 曼金德公司 用于治疗偏头痛的包含血清素受体激动剂和二酮哌嗪的组合物
KR20140027937A (ko) 2011-02-10 2014-03-07 맨카인드 코포레이션 Ｎ­보호된 비스­３，６­（４­아미노알킬）­２，５，디케토피페라진의 생성
DK2691443T3 (da) 2011-03-28 2021-05-03 Massachusetts Inst Technology Konjugerede lipomerer og anvendelser af disse
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
WO2012142320A2 (en) 2011-04-12 2012-10-18 Moerae Matrix Inc Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
US9890200B2 (en) 2011-04-12 2018-02-13 Moerae Matrix, Inc. Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
EP2717861A1 (de) * 2011-06-06 2014-04-16 Perosphere, Inc. Bioadhäsive wirkstofffreisetzungszusammensetzungen
EP4043025A1 (de) 2011-06-08 2022-08-17 Translate Bio, Inc. Lipidnanoteilchenzusammensetzungen und verfahren zur mrna-freisetzung
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US8980834B2 (en) 2011-10-10 2015-03-17 Ampio Pharmaceuticals, Inc. Treatment of degenerative joint disease
WO2013055749A1 (en) 2011-10-10 2013-04-18 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
KR20140095483A (ko) 2011-10-24 2014-08-01 맨카인드 코포레이션 통증을 치료하기 위한 방법 및 조성물
EP4074694A1 (de) 2011-10-27 2022-10-19 Massachusetts Institute Of Technology Aminosäure-, peptid- und polypeptide-lipoide, isomere, zusammensetzungen und verwendungen davon
BR112014008036A2 (pt) 2011-10-28 2017-04-11 Ampio Pharmaceuticals Inc tratamento de rinite
WO2013114374A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Dnase i polypeptides, polynucleotides encoding same, methods of producing dnase i and uses thereof in therapy
JP6185489B2 (ja) 2012-02-09 2017-08-23 ノーバス・インターナショナル・インコーポレイテッドＮｏｖｕｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ，Ｉｎｃ． 機能性ポリマー組成物
CN104284918B (zh) * 2012-03-28 2017-03-29 高剑萍 氨酯型和脲酯型化合物及其制备方法
WO2013162764A1 (en) 2012-04-27 2013-10-31 Mannkind Corp Methods for the synthesis of ethylfumarates and their use as intermediates
US20150267192A1 (en) 2012-06-08 2015-09-24 Shire Human Genetic Therapies, Inc. Nuclease resistant polynucleotides and uses thereof
CA2878617A1 (en) 2012-07-12 2014-01-16 Houston Stephen Smith Matrix and layer compositions for protection of bioactives
DK2872205T3 (en) 2012-07-12 2017-02-27 Mannkind Corp DRY POWDER FORMAL ADMINISTRATION SYSTEM
WO2014028487A1 (en) 2012-08-13 2014-02-20 Massachusetts Institute Of Technology Amine-containing lipidoids and uses thereof
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
PE20151773A1 (es) 2013-03-14 2015-12-20 Shire Human Genetic Therapies COMPOSICIONES DE ARNm DE CFTR, METODOS Y USOS RELACIONADOS
ES2708561T3 (es) 2013-03-14 2019-04-10 Translate Bio Inc Métodos para la purificación de ARN mensajero
KR102499439B1 (ko) 2013-03-15 2023-02-13 맨카인드 코포레이션 미세결정성 디케토피페라진 조성물 및 방법
SG10201707619RA (en) 2013-03-15 2017-10-30 Ampio Pharmaceuticals Inc Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
US9315472B2 (en) 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
WO2015010092A1 (en) 2013-07-18 2015-01-22 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
MX2016005239A (es) 2013-10-22 2016-08-12 Shire Human Genetic Therapies Tratamiento con acido ribonucleico mensajero para la fenilcetonuria.
EP3060257B1 (de) 2013-10-22 2021-02-24 Translate Bio, Inc. Lipidzusammensetzungen zur verabreichung von mrna
EP4276176A3 (de) 2013-10-22 2024-01-10 Translate Bio, Inc. Mrna-therapie für argininosuccinat-synthase-mangel
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10336788B2 (en) 2014-04-17 2019-07-02 Moerae Matrix, Inc. Inhibition of cardiac fibrosis in myocardial infarction
KR20220158867A (ko) 2014-04-25 2022-12-01 샤이어 휴먼 지네틱 테라피즈 인크. 메신저 rna 의 정제 방법
JP6557722B2 (ja) * 2014-05-30 2019-08-07 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド 核酸の送達のための生分解性脂質
WO2015200465A1 (en) 2014-06-24 2015-12-30 Shire Human Genetic Therapies, Inc. Stereochemically enriched compositions for delivery of nucleic acids
WO2016004202A1 (en) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
EP4066836A1 (de) 2014-08-18 2022-10-05 Ampio Pharmaceuticals, Inc. Behandlung von gelenkerkrankungen
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016057693A1 (en) 2014-10-10 2016-04-14 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhalation delivery of conjugated oligonucleotide
CA2967621A1 (en) 2014-11-17 2016-05-26 Moerae Matrix, Inc. Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition
CA2978941A1 (en) 2015-03-12 2016-09-15 Moerae Matrix, Inc. Use of mk2 inhibitor peptide-containing compositions for treating non-small cell lung cancer with same
CN104961687B (zh) * 2015-06-03 2017-07-25 苏州维泰生物技术有限公司 1,2‑二嗪衍生物及其制剂、用途
RS64331B1 (sr) 2015-06-19 2023-08-31 Massachusetts Inst Technology Alkenil supstituisani 2,5-piperazindioni i njihova primena u sastavima za isporuku agensa u organizam ili ćeliju subjekta
WO2016209969A1 (en) 2015-06-22 2016-12-29 Ampio Pharmaceuticals, Inc. Use of low molecular weight fractions of human serum albumin in treating diseases
JP2019504684A (ja) * 2016-01-29 2019-02-21 マンカインド コーポレイション 乾燥粉末吸入器
TW201809049A (zh) 2016-03-31 2018-03-16 盧伯利索先進材料有限公司 生物可分解及／或生物可吸收的熱塑性聚胺甲酸酯
AU2018224326B2 (en) 2017-02-27 2024-01-04 Translate Bio, Inc. Novel codon-optimized CFTR mRNA
US11173190B2 (en) 2017-05-16 2021-11-16 Translate Bio, Inc. Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
US20200230066A1 (en) * 2017-10-06 2020-07-23 The Regents Of The University Of California Self-Assembled Microcapsules for Optically Controlled Cargo Encapsulation and Release
CA3102967A1 (en) * 2018-06-07 2019-12-12 Mannkind Corporation Composition and method for inhalation
AU2019325702A1 (en) 2018-08-24 2021-02-25 Translate Bio, Inc. Methods for purification of messenger RNA

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1155036A (en) * 1966-07-08 1969-06-11 Ethan Allan Brown Injectionable Substance
GB1255805A (en) * 1967-12-16 1971-12-01 Albert Ag Chem Werke Improvements in delayed release pharmaceutical preparations and stabilisation of vitamins
GB1377074A (en) * 1971-07-13 1974-12-11 Beecham Group Ltd Process for preparing injectable compositions
US4400330A (en) * 1982-07-29 1983-08-23 Stauffer Chemical Company Method for preparation of N-phosphonomethylglycine
US4694082A (en) * 1985-09-23 1987-09-15 Monsanto Company Compound 1,4-diisopropyl-2,5-diketopiperazine
US4925673A (en) * 1986-08-18 1990-05-15 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents encapsulated with proteinoids
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5057317A (en) * 1987-03-24 1991-10-15 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル
US4983402A (en) * 1989-02-24 1991-01-08 Clinical Technologies Associates, Inc. Orally administerable ANF
US4976968A (en) * 1989-02-24 1990-12-11 Clinical Technologies Associates, Inc. Anhydrous delivery systems for pharmacological agents
JP2571874B2 (ja) * 1989-11-06 1997-01-16 アルカーメス コントロールド セラピューティクス，インコーポレイテッド タンパク質マイクロスフェア組成物
US5352461A (en) * 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system

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GR3019622T3 (en) 1996-07-31
US5352461A (en) 1994-10-04
ATE132744T1 (de) 1996-01-15
US5503852A (en) 1996-04-02
CA2131366A1 (en) 1993-09-30
EP0630236B1 (de) 1996-01-10
EP0630236A1 (de) 1994-12-28
WO1993018754A1 (en) 1993-09-30
DK0630236T3 (da) 1996-06-03
JPH07506818A (ja) 1995-07-27
JP2617273B2 (ja) 1997-06-04
AU680408B2 (en) 1997-07-31
AU3804493A (en) 1993-10-21
CA2131366C (en) 2003-09-23

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