DE69309954T2 - Rapamycinkohlensäureester als immunosuppressive wirkstoffe - Google Patents

Rapamycinkohlensäureester als immunosuppressive wirkstoffe

Info

Publication number
DE69309954T2
DE69309954T2 DE69309954T DE69309954T DE69309954T2 DE 69309954 T2 DE69309954 T2 DE 69309954T2 DE 69309954 T DE69309954 T DE 69309954T DE 69309954 T DE69309954 T DE 69309954T DE 69309954 T2 DE69309954 T2 DE 69309954T2
Authority
DE
Germany
Prior art keywords
rapamycine
acid esters
active ingredients
carbon acid
immunosuppressive active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69309954T
Other languages
English (en)
Other versions
DE69309954D1 (de
Inventor
David Hu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of DE69309954D1 publication Critical patent/DE69309954D1/de
Application granted granted Critical
Publication of DE69309954T2 publication Critical patent/DE69309954T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
DE69309954T 1992-11-19 1993-10-06 Rapamycinkohlensäureester als immunosuppressive wirkstoffe Expired - Fee Related DE69309954T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/979,072 US5260300A (en) 1992-11-19 1992-11-19 Rapamycin carbonate esters as immuno-suppressant agents
PCT/US1993/009548 WO1994011380A1 (en) 1992-11-19 1993-10-06 Rapamycin carbonate esters as immunosuppressant agents

Publications (2)

Publication Number Publication Date
DE69309954D1 DE69309954D1 (de) 1997-05-22
DE69309954T2 true DE69309954T2 (de) 1997-07-24

Family

ID=25526670

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69309954T Expired - Fee Related DE69309954T2 (de) 1992-11-19 1993-10-06 Rapamycinkohlensäureester als immunosuppressive wirkstoffe

Country Status (15)

Country Link
US (1) US5260300A (de)
EP (1) EP0669923B1 (de)
JP (1) JPH08503210A (de)
KR (1) KR950704330A (de)
AT (1) ATE151769T1 (de)
AU (1) AU5322094A (de)
CA (1) CA2149669A1 (de)
DE (1) DE69309954T2 (de)
DK (1) DK0669923T3 (de)
ES (1) ES2100572T3 (de)
GR (1) GR3023801T3 (de)
HK (1) HK109197A (de)
HU (1) HUT73418A (de)
SG (1) SG47595A1 (de)
WO (1) WO1994011380A1 (de)

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US5563145A (en) * 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines
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Also Published As

Publication number Publication date
EP0669923B1 (de) 1997-04-16
CA2149669A1 (en) 1994-05-26
WO1994011380A1 (en) 1994-05-26
DE69309954D1 (de) 1997-05-22
KR950704330A (ko) 1995-11-17
HUT73418A (en) 1996-07-29
HK109197A (en) 1997-08-22
AU5322094A (en) 1994-06-08
SG47595A1 (en) 1998-04-17
ES2100572T3 (es) 1997-06-16
ATE151769T1 (de) 1997-05-15
US5260300A (en) 1993-11-09
JPH08503210A (ja) 1996-04-09
DK0669923T3 (da) 1997-08-25
GR3023801T3 (en) 1997-09-30
HU9501464D0 (en) 1995-07-28
EP0669923A1 (de) 1995-09-06

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