DE69326369D1 - 14-Beta-Hydroxy-10-Deacetyl-Baccatin-III und seine Derivate als Antitumormittel - Google Patents

14-Beta-Hydroxy-10-Deacetyl-Baccatin-III und seine Derivate als Antitumormittel

Info

Publication number
DE69326369D1
DE69326369D1 DE69326369T DE69326369T DE69326369D1 DE 69326369 D1 DE69326369 D1 DE 69326369D1 DE 69326369 T DE69326369 T DE 69326369T DE 69326369 T DE69326369 T DE 69326369T DE 69326369 D1 DE69326369 D1 DE 69326369D1
Authority
DE
Germany
Prior art keywords
deacetyl
beta
hydroxy
iii
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69326369T
Other languages
English (en)
Other versions
DE69326369T2 (de
Inventor
Ezio Bombardelli
Bruno Gabetta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Publication of DE69326369D1 publication Critical patent/DE69326369D1/de
Application granted granted Critical
Publication of DE69326369T2 publication Critical patent/DE69326369T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
DE69326369T 1992-03-06 1993-02-19 14-Beta-Hydroxy-10-Deacetyl-Baccatin-III und seine Derivate als Antitumormittel Expired - Lifetime DE69326369T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI920528A IT1254517B (it) 1992-03-06 1992-03-06 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico

Publications (2)

Publication Number Publication Date
DE69326369D1 true DE69326369D1 (de) 1999-10-21
DE69326369T2 DE69326369T2 (de) 2000-03-23

Family

ID=11362321

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69326369T Expired - Lifetime DE69326369T2 (de) 1992-03-06 1993-02-19 14-Beta-Hydroxy-10-Deacetyl-Baccatin-III und seine Derivate als Antitumormittel

Country Status (19)

Country Link
US (2) US5264591A (de)
EP (1) EP0559019B1 (de)
JP (1) JP2708346B2 (de)
KR (1) KR100255525B1 (de)
CN (1) CN1051082C (de)
AT (1) ATE184599T1 (de)
CA (1) CA2091001C (de)
CZ (1) CZ284265B6 (de)
DE (1) DE69326369T2 (de)
DK (1) DK0559019T3 (de)
ES (1) ES2136096T3 (de)
FI (1) FI109904B (de)
GR (1) GR3031280T3 (de)
HK (1) HK1011686A1 (de)
HU (2) HU218665B (de)
IT (1) IT1254517B (de)
NO (1) NO305080B1 (de)
PL (1) PL171982B1 (de)
SK (1) SK279257B6 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6794523B2 (en) 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5710287A (en) * 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US6011056A (en) 1991-09-23 2000-01-04 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
US5739362A (en) * 1991-09-23 1998-04-14 Florida State University Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US6495704B1 (en) 1991-09-23 2002-12-17 Florida State University 9-desoxotaxanes and process for the preparation of 9-desoxotaxanes
US5654447A (en) * 1991-09-23 1997-08-05 Florida State University Process for the preparation of 10-desacetoxybaccatin III
US5489601A (en) * 1991-09-23 1996-02-06 Florida State University Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them
US6335362B1 (en) 1991-09-23 2002-01-01 Florida State University Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them
US5721268A (en) 1991-09-23 1998-02-24 Florida State University C7 taxane derivatives and pharmaceutical compositions containing them
US5998656A (en) * 1991-09-23 1999-12-07 Florida State University C10 tricyclic taxanes
US6018073A (en) * 1991-09-23 2000-01-25 Florida State University Tricyclic taxanes having an alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing them
US5714513A (en) * 1991-09-23 1998-02-03 Florida State University C10 taxane derivatives and pharmaceutical compositions
US5698712A (en) * 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
US5481007A (en) * 1992-06-23 1996-01-02 The Scripps Research Institute Taxoid synthesis
US5281727A (en) 1992-11-27 1994-01-25 Napro Biotherapeutics, Inc. Method of using ion exchange media to increase taxane yields
US5973160A (en) 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
ATE232854T1 (de) * 1993-03-05 2003-03-15 Univ Florida State Verfahren zur herstellung von 9-desoxotaxanen
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
FR2711370B1 (fr) * 1993-10-18 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2712289B1 (fr) * 1993-11-08 1996-01-05 Rhone Poulenc Rorer Sa Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2714053B1 (fr) * 1993-12-22 1996-03-08 Pf Medicament Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III.
CN1112433A (zh) * 1994-05-24 1995-11-29 郭明 红豆杉属植物提取物及其应用
IT1269862B (it) * 1994-05-30 1997-04-15 Indena Spa Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
US5763477A (en) * 1994-07-22 1998-06-09 Dr. Reddy's Research Foundation Taxane derivatives from 14-β-hydroxy-10 deacetylbaccatin III
FR2723094A1 (fr) * 1994-07-26 1996-02-02 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
IT1275936B1 (it) * 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
FR2732341A1 (fr) * 1995-03-27 1996-10-04 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
IT1275435B (it) * 1995-05-19 1997-08-07 Indena Spa Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono
EP0747372A1 (de) * 1995-06-06 1996-12-11 Dr. Reddy's Research Foundation Taxane Derivate aus 14-beta-hydroxy-10 Desacetylbachatin III
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
ES2151277T3 (es) * 1996-05-22 2000-12-16 Protarga Inc Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US5919815A (en) * 1996-05-22 1999-07-06 Neuromedica, Inc. Taxane compounds and compositions
US5750736A (en) * 1996-07-11 1998-05-12 Napro Biotherapeutics, Inc. Method for acylating 10-deacetylbaccatin III selectively at the c-10 position
US5856532A (en) * 1996-08-14 1999-01-05 Council Of Scientific & Industrial Research Process for the production of taxol
WO1998008833A1 (en) * 1996-08-26 1998-03-05 Bristol-Myers Squibb Company Sulfenamide taxane derivatives
WO1998013359A1 (de) * 1996-09-24 1998-04-02 Marigen S.A. Ultramikroemulsionen aus spontan dispergierbaren konzentraten mit antitumoral und antiviral wirksamen estern von baccatin-iii-verbindungen
US5811452A (en) * 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
ES2178369T3 (es) * 1998-01-14 2002-12-16 Bristol Myers Squibb Co Nuevos complejos cristalinos dce baccatina iii con imidazol, 2-metilimidazol o isopropanol.
US6002024A (en) * 1998-07-27 1999-12-14 Dabur Research Foundation Process for the isolation of 14β-hydroxy-10-deacetyl baccatin-III
US6124482A (en) * 1998-07-27 2000-09-26 Dabur Research Foundation Process for isolation of 10-deacetyl baccatin-III
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
PL366100A1 (en) * 2000-09-22 2005-01-24 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
WO2002076402A2 (en) 2001-03-23 2002-10-03 Protarga, Inc. Fatty amine drug conjugates
ES2387562T3 (es) * 2001-03-23 2012-09-26 Luitpold Pharmaceuticals, Inc. Conjugados alcohol graso-medicamento
ITMI20012186A1 (it) * 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012185A1 (it) 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20050614A1 (it) * 2005-04-12 2006-10-13 Indena Spa Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
TWI382010B (zh) * 2006-09-20 2013-01-11 Lg Chemical Ltd 非水相電解質用之添加物及使用其之二次電池
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2629818B1 (fr) * 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol

Also Published As

Publication number Publication date
KR100255525B1 (ko) 2000-05-01
CA2091001A1 (en) 1993-09-07
HU9300594D0 (en) 1993-05-28
PL171982B1 (pl) 1997-07-31
ITMI920528A0 (it) 1992-03-06
FI930978A (fi) 1993-09-07
PL297940A1 (en) 1993-11-15
US5264591A (en) 1993-11-23
GR3031280T3 (en) 1999-12-31
HUT64317A (en) 1993-12-28
CA2091001C (en) 2003-11-04
US5453520A (en) 1995-09-26
KR930019654A (ko) 1993-10-18
NO930774L (no) 1993-09-07
HU218665B (hu) 2000-10-28
SK15293A3 (en) 1993-12-08
DK0559019T3 (da) 2000-03-27
ITMI920528A1 (it) 1993-09-06
ATE184599T1 (de) 1999-10-15
NO305080B1 (no) 1999-03-29
EP0559019B1 (de) 1999-09-15
NO930774D0 (no) 1993-03-03
FI930978A0 (fi) 1993-03-04
JPH069599A (ja) 1994-01-18
CZ33693A3 (en) 1994-01-19
FI109904B (fi) 2002-10-31
JP2708346B2 (ja) 1998-02-04
ES2136096T3 (es) 1999-11-16
SK279257B6 (sk) 1998-08-05
HU211824A9 (en) 1995-12-28
CN1051082C (zh) 2000-04-05
EP0559019A1 (de) 1993-09-08
IT1254517B (it) 1995-09-25
HK1011686A1 (en) 1999-07-16
CN1076695A (zh) 1993-09-29
CZ284265B6 (cs) 1998-10-14
DE69326369T2 (de) 2000-03-23

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Legal Events

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8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC

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