DE69327165T2 - Verfahren für nadellose subkutaninjektionen - Google Patents

Verfahren für nadellose subkutaninjektionen

Info

Publication number
DE69327165T2
DE69327165T2 DE69327165T DE69327165T DE69327165T2 DE 69327165 T2 DE69327165 T2 DE 69327165T2 DE 69327165 T DE69327165 T DE 69327165T DE 69327165 T DE69327165 T DE 69327165T DE 69327165 T2 DE69327165 T2 DE 69327165T2
Authority
DE
Germany
Prior art keywords
reservoir
ampule
poppet valve
gas
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69327165T
Other languages
English (en)
Other versions
DE69327165D1 (de
Inventor
Steven Peterson
Charles Mckinnon
Paul Smith
Takaaki Nakagawa
Victor Bartholomew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioject Inc
Original Assignee
Bioject Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioject Inc filed Critical Bioject Inc
Publication of DE69327165D1 publication Critical patent/DE69327165D1/de
Application granted granted Critical
Publication of DE69327165T2 publication Critical patent/DE69327165T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31516—Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
DE69327165T 1992-07-24 1993-07-23 Verfahren für nadellose subkutaninjektionen Expired - Lifetime DE69327165T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/920,106 US5383851A (en) 1992-07-24 1992-07-24 Needleless hypodermic injection device
PCT/US1993/006940 WO1994002188A1 (en) 1992-07-24 1993-07-23 Needleless hypodermic injection methods and device

Publications (2)

Publication Number Publication Date
DE69327165D1 DE69327165D1 (de) 2000-01-05
DE69327165T2 true DE69327165T2 (de) 2000-08-24

Family

ID=25443171

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69327165T Expired - Lifetime DE69327165T2 (de) 1992-07-24 1993-07-23 Verfahren für nadellose subkutaninjektionen

Country Status (8)

Country Link
US (3) US5383851A (de)
EP (1) EP0651663B1 (de)
JP (2) JP3633615B2 (de)
AT (1) ATE187083T1 (de)
AU (1) AU676490B2 (de)
CA (1) CA2140772C (de)
DE (1) DE69327165T2 (de)
WO (1) WO1994002188A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102020134181A1 (de) 2020-12-18 2022-06-23 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids

Families Citing this family (1076)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689017B1 (fr) * 1992-03-31 1994-05-27 Mtc Medical Appareil d'injection medicale ou veterinaire.
US20090191227A1 (en) 2007-05-23 2009-07-30 Vical Incorporated Compositions and Methods for Enhancing Immune Responses to Vaccines
US5383851A (en) * 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5405333A (en) * 1992-12-28 1995-04-11 Richmond; Frank M. Liquid medicament bag with needleless connector fitting using boat assembly
US6206860B1 (en) 1993-07-28 2001-03-27 Frank M. Richmond Spikeless connection and drip chamber with valve
US5540657A (en) * 1994-07-15 1996-07-30 Collagen Corporation Delivery device for injectable materials
DE19519278A1 (de) * 1994-12-07 1997-06-12 Wolfgang Dr Med Wagner Druckstrahlinjektor
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
DE29507987U1 (de) * 1995-05-15 1996-09-19 Ferton Holding Ejektionsgerät zur Hochdruckejektion einer Flüssigkeit
US5893397A (en) * 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
US5643211A (en) 1996-02-29 1997-07-01 Medi-Ject Corporation Nozzle assembly having a frangible plunger
US5722953A (en) 1996-02-29 1998-03-03 Medi-Ject Corporation Nozzle assembly for injection device
US5865795A (en) 1996-02-29 1999-02-02 Medi-Ject Corporation Safety mechanism for injection devices
US5921967A (en) 1996-02-29 1999-07-13 Medi-Ject Corporation Plunger for nozzle assembly
US5697917A (en) 1996-02-29 1997-12-16 Medi-Ject Corporation Nozzle assembly with adjustable plunger travel gap
US5800388A (en) 1996-02-29 1998-09-01 Medi-Ject Corporation Plunger/ram assembly adapted for a fluid injector
US5785688A (en) * 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method
DE69725737T2 (de) * 1996-07-01 2004-09-23 Pharmacia Ab Abgabevorrichtung und deren bedienungsverfahren
US6458574B1 (en) 1996-09-12 2002-10-01 Transkaryotic Therapies, Inc. Treatment of a α-galactosidase a deficiency
US6106502A (en) * 1996-12-18 2000-08-22 Richmond; Frank M. IV sets with needleless fittings and valves
US5875976A (en) 1996-12-24 1999-03-02 Medi-Ject Corporation Locking mechanism for nozzle assembly
US5993412A (en) * 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
US5911703A (en) * 1997-05-22 1999-06-15 Avant Drug Delivery Systems, Inc. Two-stage fluid medicament jet injector
US5947928A (en) * 1997-06-19 1999-09-07 Mile Creek Capital, Llc Drug delivery system
US5964735A (en) * 1997-07-01 1999-10-12 Medisys Technologies, Inc. Fine needle aspiration safety syringe
EP0888790A1 (de) * 1997-07-04 1999-01-07 PowderJect Research Limited Vorrichtung zur Abgabe von Medikamententeilchen
US6569127B1 (en) * 1997-07-18 2003-05-27 Liebel-Flarsheim Company Adapter and syringe for front-loading medical fluid injector
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US6071272A (en) * 1997-10-28 2000-06-06 Hoffman; Alan S. Method for treating erectile dysfunctionality
US6610042B2 (en) 1997-12-05 2003-08-26 Felton Medical, Inc. Disposable unit-dose jet-injection syringe for pre-filled and/or transfilled liquid injectable medical drug or vaccine products and method thereof
US6541606B2 (en) * 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
US5993418A (en) * 1998-02-24 1999-11-30 Medisys Technologies, Inc. Safety syringe
US20020147143A1 (en) 1998-03-18 2002-10-10 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
EP1071377A1 (de) 1998-04-14 2001-01-31 Merck & Co., Inc. Nadellose verabreichung von polynukleotiden formationen
EP1100566A4 (de) * 1998-07-27 2002-03-20 Medi Ject Corp Lademechanismus für ein medizinisches injektionssystem
CN1202874C (zh) 1998-07-27 2005-05-25 安塔雷斯药品公司 一种注射装置
GB9818110D0 (en) * 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
US20030235557A1 (en) 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US6783509B1 (en) 1998-11-18 2004-08-31 Bioject Inc. Single-use needle-less hypodermic jet injection apparatus and method
US6132395A (en) * 1998-12-08 2000-10-17 Bioject, Inc. Needleless syringe with prefilled cartridge
US6383168B1 (en) * 1998-12-08 2002-05-07 Bioject Medical Technologies Inc. Needleless syringe with prefilled cartridge
US6406455B1 (en) * 1998-12-18 2002-06-18 Biovalve Technologies, Inc. Injection devices
DE19859137C1 (de) * 1998-12-21 2000-05-18 Ferton Holding Sa Ejektionsgerät zur Hochdruckejektion einer Flüssigkeit
US6328714B1 (en) * 1999-01-29 2001-12-11 Powderject Research Limited Particle delivery device
US6849060B1 (en) 1999-01-29 2005-02-01 Powderject Research Limited Particle delivery device
US7060048B1 (en) * 1999-04-16 2006-06-13 Powerject Research Limited Needleless syringe
EP1171195B1 (de) 1999-04-16 2005-03-16 Johnson & Johnson Consumer Companies, Inc. Vorrichtung zur iontophoretischen verabreichung von medikamenten mit internen sensoren
AU4656000A (en) 1999-04-22 2000-11-10 Gilbert Garitano Needleless permanent makeup and tattoo device
US6319230B1 (en) 1999-05-07 2001-11-20 Scimed Life Systems, Inc. Lateral needle injection apparatus and method
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
AU5595300A (en) * 1999-06-02 2000-12-18 Microheart, Inc. Devices and methods for delivering a drug
US7147633B2 (en) * 1999-06-02 2006-12-12 Boston Scientific Scimed, Inc. Method and apparatus for treatment of atrial fibrillation
US6890553B1 (en) 1999-07-08 2005-05-10 Johnson & Johnson Consumer Companies, Inc. Exothermic topical delivery device
AU6076200A (en) 1999-07-08 2001-01-30 Johnson & Johnson Consumer Companies, Inc. Exothermic bandage
AU7064700A (en) * 1999-08-20 2001-03-19 Bioject, Inc. Intramuscular injection system for injecting dna-based injectables into humans
US20050027239A1 (en) * 1999-08-20 2005-02-03 Stout Richard R. Intradermal injection system for injecting DNA-based injectables into humans
US6319224B1 (en) * 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
EP1212422B1 (de) 1999-08-24 2007-02-21 Medarex, Inc. Humane antikörper gegen ctla-4 und deren verwendungen
US7133717B2 (en) * 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6626871B1 (en) 1999-10-11 2003-09-30 Felton International, Inc. Method and apparatus for removing cap from medical device
US7074210B2 (en) * 1999-10-11 2006-07-11 Felton International, Inc. Universal protector cap with auto-disable features for needle-free injectors
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US20020193740A1 (en) 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6569123B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6494865B1 (en) 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6569143B2 (en) 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US7029457B2 (en) * 1999-11-23 2006-04-18 Felton International, Inc. Jet injector with hand piece
AU1927701A (en) * 1999-11-23 2001-06-04 Needleless Ventures, Inc. Injector assembly with driving means and locking means
US6770054B1 (en) 1999-11-23 2004-08-03 Felton International, Inc. Injector assembly with driving means and locking means
US7887506B1 (en) 1999-11-23 2011-02-15 Pulse Needlefree Systems, Inc. Safety mechanism to prevent accidental patient injection and methods of same
US6344027B1 (en) 1999-12-08 2002-02-05 Scimed Life Systems, Inc. Needle-less injection apparatus and method
US6613026B1 (en) * 1999-12-08 2003-09-02 Scimed Life Systems, Inc. Lateral needle-less injection apparatus and method
WO2001051109A1 (en) * 2000-01-07 2001-07-19 Biovalve Technologies, Inc. Injection device
PL209127B1 (pl) 2000-02-23 2011-07-29 Smithkline Beecham Biolog Środek farmaceutyczny do stosowania w immunoterapeutycznym leczeniu raka i sposób diagnozowania u pacjenta obecności lub podatności na raka
FR2805749B1 (fr) * 2000-03-01 2002-05-17 Poudres & Explosifs Ste Nale Seringue sans aiguille a deux niveaux de vitesse d'injection
US7137968B1 (en) 2000-03-13 2006-11-21 Nucryst Pharmaceuticals Corp. Transcutaneous medical device dressings and method of use
AU2001247721A1 (en) * 2000-03-23 2001-10-03 Antares Pharma, Inc. Single use disposable jet injector
US6719987B2 (en) 2000-04-17 2004-04-13 Nucryst Pharmaceuticals Corp. Antimicrobial bioabsorbable materials
US6716190B1 (en) * 2000-04-19 2004-04-06 Scimed Life Systems, Inc. Device and methods for the delivery and injection of therapeutic and diagnostic agents to a target site within a body
FR2807946B1 (fr) 2000-04-19 2002-06-07 Poudres & Explosifs Ste Nale Seringue sans aiguille fonctionnant avec un chargement pyrotechnique bicomposition
US7404815B2 (en) * 2000-05-01 2008-07-29 Lifescan, Inc. Tissue ablation by shear force for sampling biological fluids and delivering active agents
US6689101B2 (en) * 2000-05-22 2004-02-10 Pharmacia Ab Medical arrangement
US6406456B1 (en) 2000-06-08 2002-06-18 Avant Drug Delivery Systems, Inc. Jet injector
US6645169B1 (en) * 2000-06-08 2003-11-11 Avant Drug Delivery Systems, Inc. Air-in-tip jet injector
DE10029325A1 (de) * 2000-06-20 2002-01-03 Peter Lell Nadellose Injektionsvorrichtung mit pyrotechnischem Antrieb
WO2002000174A2 (en) 2000-06-28 2002-01-03 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6989157B2 (en) * 2000-07-27 2006-01-24 Nucryst Pharmaceuticals Corp. Dry powders of metal-containing compounds
US7255881B2 (en) * 2000-07-27 2007-08-14 Nucryst Pharmaceuticals Corp. Metal-containing materials
US7008647B2 (en) 2001-04-23 2006-03-07 Nucryst Pharmaceuticals Corp. Treatment of acne
US20030206966A1 (en) * 2000-07-27 2003-11-06 Burrell Robert E. Methods of inducing apoptosis and modulating metalloproteinases
CA2417279C (en) 2000-07-27 2007-04-03 Nucryst Pharmaceuticals Corp. Treatment of hyperproliferative skin disorders and diseases
US7001617B2 (en) 2001-04-23 2006-02-21 Nueryst Pharmaceuticals Corp. Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals
US20030180379A1 (en) * 2000-07-27 2003-09-25 Burrell Robert E. Solutions and aerosols of metal-containing compounds
US20030185901A1 (en) 2000-07-27 2003-10-02 Burrell Robert E. Methods of treating conditions with a metal-containing material
US7427416B2 (en) * 2000-07-27 2008-09-23 Nucryst Pharmaceuticals Corp. Methods of treating conditions using metal-containing materials
US20040191329A1 (en) * 2000-07-27 2004-09-30 Burrell Robert E. Compositions and methods of metal-containing materials
GB0022742D0 (en) 2000-09-15 2000-11-01 Smithkline Beecham Biolog Vaccine
CA2324045A1 (fr) * 2000-10-20 2002-04-20 Universite De Sherbrooke Seringue sans aiguille pour l'injection sous-cutanee de poudres medicamenteuses
FR2815544B1 (fr) * 2000-10-23 2003-02-14 Poudres & Explosifs Ste Nale Seringue sans aiguille securisee a architecture compacte
US6652483B2 (en) * 2000-11-07 2003-11-25 Avant Drug Delivery Systems, Inc. Needleless jet injector system with separate drug reservoir
US6626863B1 (en) 2000-11-22 2003-09-30 Nusaf, L.L.C. Safety syringe
EP1339442A4 (de) * 2000-11-30 2006-12-27 Biovalve Technologies Inc Injektionssysteme
GB0100756D0 (en) 2001-01-11 2001-02-21 Powderject Res Ltd Needleless syringe
CN1286536C (zh) * 2001-01-18 2006-11-29 梅德拉股份有限公司 医用注射器使用的针筒托架
US6758837B2 (en) * 2001-02-08 2004-07-06 Pharmacia Ab Liquid delivery device and method of use thereof
CA2438942A1 (en) 2001-02-23 2002-09-26 Glaxosmithkline Biologicals S.A. Influenza vaccine formulations for intradermal delivery
US6471669B2 (en) 2001-03-05 2002-10-29 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
US6645170B2 (en) * 2001-03-05 2003-11-11 Bioject Medical Technologies, Inc. Simplified disposable needle-free injection apparatus and method
US20020139088A1 (en) 2001-03-08 2002-10-03 Archie Woodworth Polymeric syringe body and stopper
US20020172615A1 (en) * 2001-03-08 2002-11-21 Archie Woodworth Apparatus for and method of manufacturing a prefilled sterile container
CA2440983A1 (en) 2001-03-14 2002-09-26 Penjet Corporation System and method for removing dissolved gas from a solution
ZA200200808B (en) * 2001-03-22 2002-08-12 Roche Diagnostics Gmbh Needleless hypodermic injection system, application device and medication cartridge therefor.
US7795218B2 (en) 2001-04-12 2010-09-14 Bioaxone Therapeutique Inc. ADP-ribosyl transferase fusion variant proteins
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
US20050192530A1 (en) * 2001-04-13 2005-09-01 Penjet Corporation Method and apparatus for needle-less injection with a degassed fluid
US6613010B2 (en) 2001-04-13 2003-09-02 Penjet Corporation Modular gas-pressured needle-less injector
DE60210441T2 (de) * 2001-04-23 2006-11-16 Nucryst Pharmaceuticals Corp., Fort Saskatchewan Arzneimittel oder pflaster enthaltend ein metall wie silber, gold, platin oder palladium als antimikrobiellen wirkstoff und dessen verwendung in der behandlung von hautentzündungen
WO2002087663A2 (en) 2001-04-27 2002-11-07 Penjet Corporation Method and apparatus for filling or refilling a needle-less injector
CA2446788A1 (en) 2001-05-09 2002-11-14 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
MY134424A (en) 2001-05-30 2007-12-31 Saechsisches Serumwerk Stable influenza virus preparations with low or no amount of thiomersal
US20100221284A1 (en) 2001-05-30 2010-09-02 Saech-Sisches Serumwerk Dresden Novel vaccine composition
US6648850B2 (en) * 2001-06-08 2003-11-18 Bioject, Inc. Durable needle-less jet injector apparatus and method
BR0210628A (pt) * 2001-06-29 2004-08-10 Becton Dickinson Co Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
US7544188B2 (en) * 2001-07-19 2009-06-09 Intelliject, Inc. Medical injector
US8440791B2 (en) * 2001-09-06 2013-05-14 Mgp Biotechnologies, Llc Thimerosal removal device
US7767872B2 (en) * 2001-09-06 2010-08-03 Mpg Biotechnologies, Llc Thimerosal removal device
US6669664B2 (en) 2001-09-07 2003-12-30 Avant Drug Delivery Systems, Inc. Vacuum control cycle for jet injector
US20060068405A1 (en) * 2004-01-27 2006-03-30 Alex Diber Methods and systems for annotating biomolecular sequences
EP2322626A1 (de) * 2001-09-20 2011-05-18 Glaxo Group Limited Codon optimisierte HIV-GAG DNA Impfstoffe
US6824526B2 (en) 2001-10-22 2004-11-30 Penjet Corporation Engine and diffuser for use with a needle-less injector
GB0125506D0 (en) 2001-10-24 2001-12-12 Weston Medical Ltd Needle free injection method and apparatus
PT1441787E (pt) * 2001-11-09 2010-08-02 Alza Corp Auto-injector pneumático
US6607510B2 (en) 2001-11-09 2003-08-19 Bioject Medical Technologies Inc. Disposable needle-free injection apparatus and method
NZ532146A (en) * 2001-11-09 2006-07-28 Alza Corp Collapsible syringe cartridge
TWI222370B (en) * 2001-12-14 2004-10-21 Roche Diagnostics Gmbh Needleless hypodermic injection device
CA2476755C (en) 2001-12-17 2014-08-26 Corixa Corporation Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
WO2003074102A2 (en) * 2002-03-04 2003-09-12 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
US6912417B1 (en) * 2002-04-05 2005-06-28 Ichor Medical Systmes, Inc. Method and apparatus for delivery of therapeutic agents
CN1324047C (zh) 2002-04-12 2007-07-04 先灵公司 G蛋白偶联受体的配体与方法
JP5570677B2 (ja) 2002-04-25 2014-08-13 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド α−ガラクトシダーゼＡ欠損症の治療
EP2316922B1 (de) 2002-05-24 2013-05-22 Merck Sharp & Dohme Corp. Humaner neutraliserender Anti-IGFR Antikörper
US7238167B2 (en) * 2002-06-04 2007-07-03 Bioject Inc. Needle-free injection system
US6676630B2 (en) 2002-06-04 2004-01-13 Bioject Medical Technologies, Inc. Needle-free injection system
US7156823B2 (en) * 2002-06-04 2007-01-02 Bioject Inc. High workload needle-free injection system
US20040132058A1 (en) 2002-07-19 2004-07-08 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
US6883222B2 (en) * 2002-10-16 2005-04-26 Bioject Inc. Drug cartridge assembly and method of manufacture
KR20100050587A (ko) 2002-10-17 2010-05-13 젠맵 에이/에스 Ｃｄ20에 대한 인간 모노클로날 항체
AU2003286575A1 (en) * 2002-10-22 2004-05-13 Nucryst Pharmaceuticals Corp. Prophylactic treatment methods
DE10254601A1 (de) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
AU2003275895B2 (en) * 2002-11-25 2009-02-05 Tecpharma Licensing Ag Auto-injector comprising a resettable releasing safety device
CA2512108C (en) 2003-01-06 2013-04-02 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
US7960522B2 (en) 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
EP2290107A1 (de) 2003-01-07 2011-03-02 Dyax Corporation Kunitzdomänenbibliothek
SI2857036T1 (sl) 2003-01-31 2017-05-31 Mount Sinai School Of Medicine Of New York University Kombinirana terapija za zdravljenje motenj pomanjkanja proteinov
US6935384B2 (en) * 2003-02-19 2005-08-30 Bioject Inc. Needle-free injection system
FR2852517B1 (fr) 2003-03-21 2005-11-11 Dispositif d'injection sans aiguille a cartouche pyrotechnique et procede d'assemblage d'un tel dispositif
US20040260234A1 (en) * 2003-04-21 2004-12-23 Ravi Srinivasan Apparatus and methods for repetitive microjet durg delivery priority statement
US20060184101A1 (en) * 2003-04-21 2006-08-17 Ravi Srinivasan Microjet devices and methods for drug delivery
CA2523142A1 (en) 2003-04-23 2004-11-04 Medarex, Inc. Humanized antibodies to interferon alpha receptor-1 (ifnar-1)
CN1784248B (zh) * 2003-05-09 2010-11-10 森下龙一 收容药剂的无针注射器
AU2004272972A1 (en) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Recombinant carrier molecule for expression, delivery and purification of target polypeptides
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
IL157981A (en) 2003-09-17 2014-01-30 Elcam Medical Agricultural Cooperative Ass Ltd Auto injector
GB0325836D0 (en) * 2003-11-05 2003-12-10 Celltech R&D Ltd Biological products
PL1983000T3 (pl) * 2003-11-21 2016-02-29 Ucb Biopharma Sprl Sposób leczenia stwardnienia rozsianego przez hamowanie aktywności IL-17
EP1685865A4 (de) * 2003-11-21 2009-12-30 Zhongshan Botai Pharmaceutic I Spritze zum vormischen eines pulverförmigen medikaments
EP2418220B1 (de) 2003-12-10 2017-08-02 E. R. Squibb & Sons, L.L.C. Interferon-Alpha-Antikörper und deren Verwendungen
KR20130133302A (ko) 2003-12-10 2013-12-06 메다렉스, 인코포레이티드 Ｉｐ―１０ 항체 및 그의 용도
EP1729848B1 (de) 2004-03-08 2015-04-29 Ichor Medical Systems Inc. Verbessertes gerät für die elektrisch vermittelte abgabe von therapeutika
IL160891A0 (en) 2004-03-16 2004-08-31 Auto-mix needle
DE102004024617A1 (de) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung
AU2005244942A1 (en) * 2004-05-19 2005-12-01 Wyeth Modulation of immunoglobulin production and atopic disorders
US7717874B2 (en) * 2004-05-28 2010-05-18 Bioject, Inc. Needle-free injection system
KR20150041193A (ko) 2004-06-21 2015-04-15 메다렉스, 엘.엘.시. 인터페론 알파 수용체 1 항체 및 그의 용도
US7329737B2 (en) 2004-08-03 2008-02-12 Dyax Corp. Antibodies that bind hK-1
GB0417852D0 (en) 2004-08-11 2004-09-15 Biotica Tech Ltd Production of polyketides and other natural products
US20060040895A1 (en) * 2004-08-19 2006-02-23 Kipling Thacker Aesthetic use of hyaluronan
CA2478458A1 (en) * 2004-08-20 2006-02-20 Michael Panzara Treatment of pediatric multiple sclerosis
CA2580103C (en) 2004-09-22 2021-11-16 Glaxosmithkline Biologicals S.A. Immunogenic composition
US9492400B2 (en) * 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
EP1817590A2 (de) 2004-11-08 2007-08-15 Schering Corporation Tumorassoziation von mdl-1 und entsprechende verfahren
EP1824976A4 (de) 2004-11-12 2008-07-09 Univ British Columbia Antimikrobielle peptide
CN103169965A (zh) 2004-11-19 2013-06-26 比奥根艾迪克Ma公司 治疗多发性硬化
US7648483B2 (en) 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems and methods for medicament delivery
AU2004325202B2 (en) 2004-11-22 2009-02-19 Kaleo, Inc. Devices, systems, and methods for medicament delivery
US7648482B2 (en) * 2004-11-22 2010-01-19 Intelliject, Inc. Devices, systems, and methods for medicament delivery
US7947017B2 (en) 2004-11-22 2011-05-24 Intelliject, Inc. Devices, systems and methods for medicament delivery
US10737028B2 (en) 2004-11-22 2020-08-11 Kaleo, Inc. Devices, systems and methods for medicament delivery
US11590286B2 (en) 2004-11-22 2023-02-28 Kaleo, Inc. Devices, systems and methods for medicament delivery
EP2532378B1 (de) * 2004-12-01 2016-04-27 AcuShot, Inc. Nadelloser Injektor
MX2007006640A (es) 2004-12-03 2007-06-19 Schering Corp Biomarcadores para la preseleccion de pacientes para la terapia con anti-receptor 1 del factor de crecimiento similar a la insulina.
JP2008522971A (ja) * 2004-12-03 2008-07-03 バイオジェン・アイデック・エムエイ・インコーポレイテッド 多発性硬化症の発症の遅延または予防
US7351226B1 (en) * 2004-12-07 2008-04-01 Glenn Herskowitz Medical infusion pump
US20060183893A1 (en) * 2005-01-25 2006-08-17 North Don A Nucleic acids for apoptosis of cancer cells
JP2008527996A (ja) * 2005-01-25 2008-07-31 スカイ、ジェネティクス、インク 癌細胞のアポトーシスのための核酸
US8361026B2 (en) 2005-02-01 2013-01-29 Intelliject, Inc. Apparatus and methods for self-administration of vaccines and other medicaments
US8206360B2 (en) 2005-02-01 2012-06-26 Intelliject, Inc. Devices, systems and methods for medicament delivery
US7731686B2 (en) 2005-02-01 2010-06-08 Intelliject, Inc. Devices, systems and methods for medicament delivery
US9022980B2 (en) 2005-02-01 2015-05-05 Kaleo, Inc. Medical injector simulation device
US8231573B2 (en) * 2005-02-01 2012-07-31 Intelliject, Inc. Medicament delivery device having an electronic circuit system
PL2058020T3 (pl) 2005-02-01 2013-03-29 Kaleo Inc Urządzenie do podawania leków
EP1859277A4 (de) 2005-02-17 2010-03-17 Biogen Idec Inc Behandlung neurologischer störungen
ES2498794T3 (es) 2005-02-18 2014-09-25 Medarex, L.L.C. Anticuerpos monoclonales contra CD30 que carecen de restos fucosilo
US20100061994A1 (en) * 2005-03-11 2010-03-11 Rose Mary Sheridan Medical uses of 39-desmethoxyrapamycin and analogues thereof
GB0504994D0 (en) * 2005-03-11 2005-04-20 Biotica Tech Ltd Novel compounds
EP1861122A1 (de) 2005-03-23 2007-12-05 GlaxoSmithKline Biologicals S.A. Zusammensetzung
EA015584B1 (ru) 2005-03-23 2011-10-31 Генмаб А/С Антитело к cd38 человека и его применение
EP1863519B1 (de) 2005-03-31 2013-09-25 The General Hospital Corporation Modulation von hgf/hgfr-aktivität zur behandlung von lymphödem
MX2007012226A (es) 2005-04-04 2007-12-10 Univ Florida Analogos de polieter de desferritiocina.
CN109485727A (zh) 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
EP1896083B1 (de) 2005-05-17 2016-03-02 Amicus Therapeutics, Inc. Verfahren zur behandlung von pompe-krankheit mit 1-desoxynojirimycin und derivaten
HUE030701T2 (hu) 2005-05-27 2017-05-29 Biogen Ma Inc Tweak-kötõ antitestek
US20060271014A1 (en) * 2005-05-31 2006-11-30 Mallinckrodt Inc. Heat retention device for a syringe and methods of use
US20070118093A1 (en) * 2005-06-20 2007-05-24 Von Muhlen Marcio G High-speed jet devices for drug delivery
DK1907424T3 (en) 2005-07-01 2015-11-09 Squibb & Sons Llc HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED death ligand 1 (PD-L1)
WO2007016643A2 (en) * 2005-08-01 2007-02-08 Mount Sinai School Of Medicine Of New York University A method for extending longevity using npc1l1 antagonists
KR101446025B1 (ko) * 2005-08-03 2014-10-01 아이바이오, 인크. 면역글로불린의 생산을 위한 조성물 및 방법
US8998881B2 (en) * 2005-08-10 2015-04-07 Alza Corporation Method for delivering drugs to tissue under microjet propulsion
EP1762575A1 (de) * 2005-09-12 2007-03-14 Ganymed Pharmaceuticals AG Identifizierung Tumor-assoziierter Antigene für Diagnoseund Therapie
US8124738B2 (en) 2005-09-26 2012-02-28 Medarex, Inc. Human monoclonal antibodies to CD70
NZ567124A (en) 2005-10-21 2011-08-26 Novartis Ag Human antibodies against Interleukin-13 and therapeutic uses to treat asthma
US20070099246A1 (en) * 2005-11-03 2007-05-03 Sandy John D Antibodies, assays and kits to quantitate cartilage destruction
EP3058972A1 (de) 2005-11-17 2016-08-24 Zogenix, Inc. Abgabe von viskosen formulierungen durch nadellose injektion
EP1790664A1 (de) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoklonale Antikörper gegen Claudin-18 zur Behandlung von Krebs
JP2009518080A (ja) * 2005-12-05 2009-05-07 中山博泰薬械有限公司 自動注射器
SG174783A1 (en) 2005-12-08 2011-10-28 Medarex Inc Human monoclonal antibodies to fucosyl-gm1 and methods for using anti-fucosyl-gm1 antibodies
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
US9267937B2 (en) * 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
ES2707499T3 (es) 2005-12-22 2019-04-03 Glaxosmithkline Biologicals Sa Vacuna de conjugado de polisacárido neumocócico
EP2441846A3 (de) 2006-01-09 2012-07-25 The Regents Of the University of California Immunstimulierende Kombinationen aus TNFRSF, TLR, NLR, RHR, purinergischem Rezeptor, und Zytokin-Rezeptor-Antagonisten für Impfstoffe und die Tumorimmuntherapie
US20070166774A1 (en) * 2006-01-17 2007-07-19 Groman Ernest V Functional immunoassay
DK1986612T3 (da) 2006-02-07 2012-10-29 Shire Human Genetic Therapies Stabiliserede proteinsammensætninger med en fri thioldel
EP2338547B1 (de) * 2006-02-09 2013-04-17 DEKA Products Limited Partnership Fluidzufuhrsysteme
US8277816B2 (en) * 2006-02-13 2012-10-02 Fraunhofer Usa, Inc. Bacillus anthracis antigens, vaccine compositions, and related methods
CA2642054C (en) * 2006-02-13 2017-11-21 Fraunhofer Usa, Inc. Influenza antigens, vaccine compositions, and related methods
WO2007095320A2 (en) * 2006-02-13 2007-08-23 Fraunhofer Usa, Inc. Hpv antigens, vaccine compositions, and related methods
BRPI0708063A2 (pt) * 2006-02-17 2011-05-17 Alan L Buchman dispositivos de limpeza de cateter
WO2007106415A2 (en) * 2006-03-10 2007-09-20 Massachusetts Institute Of Technology Triggered self-assembly conjugates and nanosystems
US7666912B2 (en) 2006-03-23 2010-02-23 Massachusetts Eye And Ear Infirmary Compositions and methods for reducing body fat
US20080045471A1 (en) * 2006-03-27 2008-02-21 North Don A Nucleic Acids For Apoptosis Of Cancer Cells
EP1998802A2 (de) 2006-03-30 2008-12-10 GlaxoSmithKline Biologicals S.A. Immunogene zusammensetzung
ES2776100T3 (es) 2006-03-31 2020-07-29 Massachusetts Inst Technology Sistema para el suministro dirigido de agentes terapéuticos
WO2007120638A2 (en) * 2006-04-12 2007-10-25 President And Fellows Of Harvard College Methods and compositions for modulating glycosylation
AU2007240732B2 (en) * 2006-04-21 2013-07-04 Amgen, Inc. Buffering agents for biopharmaceutical formulations
US20070258941A1 (en) * 2006-05-02 2007-11-08 Pfister Brian E Methods and compositions for remediation of disc herniation by modifying structure
CN101573141B (zh) 2006-05-15 2016-05-04 麻省理工学院 用于功能性颗粒的聚合物
WO2007137117A2 (en) * 2006-05-17 2007-11-29 Massachusetts Institute Of Technology Aptamer-directed drug delivery
JP5496658B2 (ja) 2006-05-25 2014-05-21 バイオジェン・アイデック・エムエイ・インコーポレイテッド 脳卒中を処置する方法
US9150626B2 (en) * 2006-06-02 2015-10-06 President And Fellows Of Harvard College Protein surface remodeling
WO2010123874A1 (en) 2009-04-20 2010-10-28 Oxford Biotherapeutics Ltd. Antibodies specific to cadherin-17
WO2007150030A2 (en) 2006-06-23 2007-12-27 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
ES2427924T3 (es) 2006-06-30 2013-11-04 Merck Sharp & Dohme Corp. Biomarcador IGFBP2
JP5605895B2 (ja) 2006-07-04 2014-10-15 ゲンマブ エー／エス Ｃｏｐｄを処置するためのｃｄ２０結合分子
EP2422810B1 (de) 2006-07-17 2014-10-22 GlaxoSmithKline Biologicals s.a. Influenzaimpfstoff
US20080033347A1 (en) * 2006-08-03 2008-02-07 Becton, Dickinson And Company Detachable needle syringe having reduced dead space
US7618396B2 (en) * 2006-08-09 2009-11-17 Avant Medical Corp. Injection system with hidden needles
WO2008021367A2 (en) * 2006-08-11 2008-02-21 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
WO2008018641A1 (en) 2006-08-11 2008-02-14 Ono Pharmaceutical Co., Ltd. Monoclonal antibodies against stromal derived factor-1 (sdf-1)
US20090269342A1 (en) * 2006-08-14 2009-10-29 Massachusetts Institute Of Technology Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto
WO2008021415A2 (en) * 2006-08-14 2008-02-21 Massachusetts Institute Of Technology Glycan data mining system
JP2010502220A (ja) 2006-09-05 2010-01-28 メダレックス インコーポレーティッド 骨形態形成タンパク質およびその受容体に対する抗体ならびにその使用方法
US7942845B2 (en) * 2006-09-19 2011-05-17 Bioject, Inc. Needle-free injector and process for providing serial injections
SI2486941T1 (sl) 2006-10-02 2017-08-31 E. R. Squibb & Sons, L.L.C. Humana protitelesa, ki vežejo CXCR4 in njihova uporaba
MX2009003635A (es) * 2006-10-06 2009-04-22 Amgen Inc Formulaciones de anticuerpos estables.
US7547293B2 (en) 2006-10-06 2009-06-16 Bioject, Inc. Triggering mechanism for needle-free injector
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
CN101522218B (zh) 2006-10-12 2012-09-26 葛兰素史密丝克莱恩生物有限公司 包含水包油乳液佐剂的疫苗
PL2086582T3 (pl) 2006-10-12 2013-04-30 Glaxosmithkline Biologicals Sa Kompozycja zawierająca adiuwant w postaci emulsji typu olej w wodzie
CA2666682C (en) 2006-10-19 2014-07-08 Merck & Co., Inc. Anti-il-13r.alpha.1 antibodies and their uses thereof
ES2925992T3 (es) * 2006-10-20 2022-10-20 Amgen Inc Formulaciones estables de polipéptidos
KR20090071652A (ko) 2006-10-20 2009-07-01 바이오겐 아이덱 엠에이 인코포레이티드 가용성 림프독소-베타-수용체를 이용한 탈수초성 장애의 치료
US8618248B2 (en) 2006-10-31 2013-12-31 President And Fellows Of Harvard College Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides
US20090124996A1 (en) * 2006-11-03 2009-05-14 Scott Heneveld Apparatus and methods for injecting high viscosity dermal fillers
NZ577085A (en) 2006-11-15 2012-06-29 Medarex Inc Human monoclonal antibodies to btla and methods of use
US20100303723A1 (en) * 2006-11-20 2010-12-02 Massachusetts Institute Of Technology Drug delivery systems using fc fragments
KR101552735B1 (ko) 2006-12-01 2015-09-14 메다렉스, 엘.엘.시. 씨디22에 결합하는 인간 항체 및 이의 용도
CA2671447A1 (en) 2006-12-01 2008-06-12 Anterios, Inc. Amphiphilic entity nanoparticles
US20090093551A1 (en) * 2006-12-08 2009-04-09 Bhatia Sangeeta N Remotely triggered release from heatable surfaces
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
KR20090088946A (ko) 2006-12-14 2009-08-20 메다렉스, 인코포레이티드 씨디70에 결합하는 인간 항체 및 이의 용도
ES2748526T3 (es) * 2006-12-21 2020-03-17 Amgen Inc Formulaciones tamponadas estables que contienen polipéptidos
CN105622463B (zh) 2006-12-26 2019-02-22 兰休斯医疗成像公司 用于使心脏神经支配成像的配体
US8684968B2 (en) * 2006-12-29 2014-04-01 Aktivpak, Inc. Hypodermic drug delivery reservoir and apparatus
EP2125075A2 (de) 2007-01-22 2009-12-02 Intelliject, Inc. Medizinischer injektor mit konformitätsverfolgung und -überwachung
PT2118123E (pt) 2007-01-31 2016-02-10 Harvard College Péptidos de p53 estabilizados e suas utilizações
WO2008098165A2 (en) * 2007-02-09 2008-08-14 Massachusetts Institute Of Technology Oscillating cell culture bioreactor
EP3248617A3 (de) 2007-02-16 2018-02-21 Merrimack Pharmaceuticals, Inc. Antikörper gegen erbb3 und verwendungen davon
WO2008103997A2 (en) * 2007-02-23 2008-08-28 Bioject Inc. Needle-free injection devices and drug delivery systems therefor
EP1970384A1 (de) 2007-03-14 2008-09-17 Ganymed Pharmaceuticals AG Monoklonale Antikörper zur Krebsbehandlung
WO2008115433A1 (en) 2007-03-15 2008-09-25 University Of Florida Desferrithiocin polyether analogues
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
KR101540822B1 (ko) 2007-03-27 2015-07-30 씨 레인 바이오테크놀로지스, 엘엘씨 항체 대용물 경쇄 서열을 포함하는 구축물 및 라이브러리
EP2508531B1 (de) 2007-03-28 2016-10-19 President and Fellows of Harvard College Geheftete Polypeptide
WO2008124639A2 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Poly (amino acid) targeting moieties
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US8778348B2 (en) * 2007-04-28 2014-07-15 Ibio Inc. Trypanosoma antigens, vaccine compositions, and related methods
GB0708758D0 (en) 2007-05-04 2007-06-13 Powderject Res Ltd Particle cassettes and process thereof
EP1997832A1 (de) 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Monoklonale Antikörper gegen Claudin-18 zur Behandlung von Krebs
BRPI0812400A2 (pt) 2007-06-05 2014-10-29 Univ Yale Unidade, hibridoma, composição farmacêutica, método para identificar uma unidade, anticorpo isolado a uma unidade de ligação de antígeno do mesmo, molécula peptídica, e, uso da unidade.
MX2009013118A (es) * 2007-06-14 2010-03-04 Crucell Switzerland Ag Vacuna intradermica contra la influenza.
TWI614028B (zh) 2007-06-14 2018-02-11 百健Ｍａ公司 抗體調配物
WO2008156676A1 (en) 2007-06-15 2008-12-24 President And Fellows Of Harvard College Methods and compositions for detecting and modulating o-glycosylation
RS54349B1 (en) 2007-06-26 2016-02-29 Glaxosmithkline Biologicals S.A. VACCINE CONTAINING STREPTOCOCCUS PNEUMONIAE Capsular POLYSACCHARIDE CONJUGATES
WO2009009759A2 (en) 2007-07-11 2009-01-15 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
DE102007034871A1 (de) * 2007-07-24 2009-01-29 Lts Lohmann Therapie-Systeme Ag Einweginjektor mit handbetätigbarem Kolben
EP2185692A4 (de) 2007-08-10 2012-05-02 Medarex Inc Hco32 und hco27 sowie entsprechende beispiele
CA2696764A1 (en) * 2007-08-20 2009-02-26 Fraunhofer Usa, Inc. Prophylactic and therapeutic influenza vaccines, antigens, compositions, and methods
US8415455B2 (en) 2007-09-04 2013-04-09 Compugen Ltd Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics
GB0717337D0 (en) 2007-09-06 2007-10-17 Ucb Pharma Sa Method of treatment
US8604004B2 (en) * 2007-10-04 2013-12-10 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
CN105770878A (zh) 2007-10-12 2016-07-20 麻省理工学院 疫苗纳米技术
AR068767A1 (es) 2007-10-12 2009-12-02 Novartis Ag Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina
AU2008314486B2 (en) * 2007-10-15 2014-06-26 Jingang Medicine (Australia) Pty Ltd Construct system and uses therefor
CN101951954A (zh) 2007-11-02 2011-01-19 诺瓦提斯公司 调节低密度脂蛋白受体相关蛋白6(lrp6)的分子和方法
JP5701606B2 (ja) 2007-11-07 2015-04-15 セルデックス セラピューティクス インコーポレイテッド ヒト樹状細胞および上皮細胞２０５（ｄｅｃ−２０５）に結合する抗体
US20090137949A1 (en) * 2007-11-26 2009-05-28 Bioject Inc. Needle-free injection device with nozzle auto-disable
US8617099B2 (en) * 2007-11-26 2013-12-31 Bioject Inc. Injection device plunger auto-disable
RU2570559C2 (ru) 2007-12-17 2015-12-10 Пфайзер Лимитед Лечение интерстициального цистита
EP2231258A1 (de) 2007-12-21 2010-09-29 Aesthetic Sciences Corporation Unabhängige druckinjektionsvorrichtung
WO2009086463A1 (en) 2007-12-28 2009-07-09 Aktivpak, Inc. Dispenser and therapeutic package suitable for administering a therapeutic substance to a subject
DE102008011873A1 (de) 2007-12-30 2009-07-09 Idelevich, Evgeny Applikationsvorrichtung und -verfahren zur automatisierten Medikamentenabgabe bei arteriellem Hypertonus
CA2711330A1 (en) * 2008-01-03 2009-07-16 Massachusetts Institute Of Technology Decoy influenza therapies
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP5777886B2 (ja) 2008-01-22 2015-09-09 フンダカオ・デ・アムパロ・アー・ペスクゥイサ・ド・エスタド・デ・サン・パウロ（エフエーピーイーエスピー） ペプチド組成物，及びその使用
DK2240203T3 (da) 2008-02-05 2014-05-05 Pfizer Alfa5-beta1-antistoffer og deres anvendelser
BR122020023189B1 (pt) 2008-02-08 2022-02-01 Astrazeneca Ab Uso de uma composição farmacêutica compreendendo um anticorpo específico para ifnar1
WO2009126691A1 (en) * 2008-04-09 2009-10-15 Infinity Pharmaceuticals, Inc Inhibitors of fatty acid amide hydrolase
WO2009127676A1 (en) 2008-04-16 2009-10-22 Glaxosmithkline Biologicals S.A. Vaccine
US20110112040A1 (en) * 2008-04-28 2011-05-12 President And Fellows Of Harvard College Supercharged proteins for cell penetration
AU2009241847B2 (en) * 2008-04-28 2014-07-10 Zogenix, Inc. Novel formulations for treatment of migraine
EP2383292A1 (de) 2008-05-02 2011-11-02 Novartis AG Verbesserte Bindemoleküle auf Fibronectin-Basis und ihre Verwendung
US8021344B2 (en) 2008-07-28 2011-09-20 Intelliject, Inc. Medicament delivery device configured to produce an audible output
USD994111S1 (en) 2008-05-12 2023-08-01 Kaleo, Inc. Medicament delivery device cover
KR20110022000A (ko) * 2008-05-30 2011-03-04 다나-파버 캔서 인스티튜트 인크. 감수분열 키네신-연관된 질환의 치료 방법
BRPI0913189A2 (pt) * 2008-05-30 2016-01-12 Allergan Inc dispositivo de injeção para cargas de aumento de tecido mole, agentes bioativos e outros materiais biocompatíveis em forma líquida ou gel
WO2009150623A1 (en) 2008-06-13 2009-12-17 Pfizer Inc Treatment of chronic prostatitis
CN102625813A (zh) 2008-06-20 2012-08-01 诺华公司 具有降低的聚集的免疫球蛋白
CN105147608B (zh) 2008-06-26 2019-12-10 安特里奥公司 真皮递送
US8680020B2 (en) 2008-07-15 2014-03-25 Academia Sinica Glycan arrays on PTFE-like aluminum coated glass slides and related methods
CN102159203A (zh) * 2008-07-23 2011-08-17 麻省理工学院 组蛋白脱乙酰酶1(hdac1)的活化防范dna损伤和增加神经元存活
US20110144306A1 (en) * 2008-07-23 2011-06-16 President And Fellows Of Harvard College Ligation of stapled polypeptides
EP3629022A1 (de) 2008-07-25 2020-04-01 Richard W. Wagner Proteinscreeningverfahren
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
EP2166021A1 (de) 2008-09-16 2010-03-24 Ganymed Pharmaceuticals AG Monoklonale Antikörper zur Krebsbehandlung
WO2010033882A2 (en) * 2008-09-18 2010-03-25 Becton, Dickinson And Company Medical injector with slidable sleeve activation
KR102097887B1 (ko) 2008-09-26 2020-04-06 다나-파버 캔서 인스티튜트 인크. 인간 항-ｐｄ-１, ｐｄ-ｌ１, 및 ｐｄ-ｌ2 항체 및 그의 용도
WO2010037046A1 (en) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Humanized neuraminidase antibody and methods of use thereof
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
CN104740631B (zh) 2008-10-29 2019-04-16 阿布林克斯公司 单域抗原结合性分子的制剂
CA2743904A1 (en) 2008-11-17 2010-05-20 The Regents Of The University Of Michigan Cancer vaccine compositions and methods of using the same
SI2384210T1 (en) 2008-12-02 2018-02-28 Allergan, Inc. Injection device
EP2193817A1 (de) * 2008-12-02 2010-06-09 Sanofi-Aventis Deutschland GmbH Zur Verwendung in Arzneimittelabgabevorrichtungen geeignete Antriebsanordnung und Arzneimittelabgabevorrichtung
WO2010067345A1 (en) * 2008-12-08 2010-06-17 Perf-Action Technologies Ltd. Erosion prevention for o-rings in a high pressure injection device
CA2745492A1 (en) 2008-12-08 2010-06-17 Compugen Ltd. A polyclonal or monoclonal antibody or antibody binding fragment that binds to a tmem154 polypeptide
EP2376619A4 (de) 2008-12-15 2012-07-04 Greenlight Biosciences Inc Verfahren zur flusssteuerung bei stoffwechselwegen
EP3998479A1 (de) 2008-12-19 2022-05-18 Medirista Biotechnologies AB Oxidiertes cardiolipin als neuartiger proinflammatorischer faktor
KR20110134380A (ko) * 2008-12-22 2011-12-14 그린라이트 바이오사이언시스, 아이엔씨. 화합물의 제조를 위한 조성물 및 방법
CN102341412B (zh) 2009-03-05 2018-01-05 梅达雷克斯有限责任公司 特异于cadm1 的全人抗体
GB0904540D0 (en) 2009-03-17 2009-04-29 Biotica Tech Ltd Novel compounds and methods for their production
AU2010234449A1 (en) 2009-04-07 2011-11-03 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
JP2012523424A (ja) 2009-04-07 2012-10-04 インフイニトイ プハルマセウトイカルス インコーポレイテッド 脂肪酸アミドヒドロラーゼの阻害薬
EP2416656B1 (de) 2009-04-09 2015-12-23 Amicus Therapeutics, Inc. Verfahren zur prävention und/oder behandlung lysosomaler speicherkrankheiten
EP2419137A4 (de) * 2009-04-17 2013-01-09 Biogen Idec Inc Zusammensetzungen und verfahren zur behandlung von akuter myelogener leukämie
DK2243505T3 (en) * 2009-04-23 2018-04-30 Bayer Healthcare Llc Spraying devices and methods of producing spraying devices
CA2993053A1 (en) 2009-04-27 2010-11-04 Novartis Ag Antagonistic activin receptor iib (actriib) antibodies for increasing muscle growth
EP2424894A1 (de) 2009-04-27 2012-03-07 Novartis AG Zusammensetzungen und verfahhren zur anwendung von für die beta1-untereinheit des il-12-rezeptors spezifischen antikörpern
JP2012525146A (ja) 2009-04-28 2012-10-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ 細胞透過のための過剰に荷電されたタンパク質
US8435523B2 (en) 2009-05-04 2013-05-07 Abbott Research B.V. Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
CN102482345A (zh) 2009-05-13 2012-05-30 航道生物技术有限责任公司 针对流感病毒的中和分子
US8927551B2 (en) * 2009-05-18 2015-01-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US9149465B2 (en) * 2009-05-18 2015-10-06 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
US8765735B2 (en) * 2009-05-18 2014-07-01 Infinity Pharmaceuticals, Inc. Isoxazolines as inhibitors of fatty acid amide hydrolase
WO2010141074A2 (en) 2009-06-01 2010-12-09 President And Fellows Of Harvard College O-glcnac transferase inhibitors and uses thereof
WO2010141430A2 (en) 2009-06-01 2010-12-09 Shriners Hospitals For Children A cloned transmembrane receptor for 24-hydroxylated vitamin d compounds and uses thereof
US8974423B2 (en) * 2009-06-01 2015-03-10 Sanofi-Aventis Deutschland Gmbh Resettable drug delivery device
WO2010141902A2 (en) 2009-06-04 2010-12-09 Novartis Ag METHODS FOR IDENTIFICATION OF SITES FOR IgG CONJUGATION
WO2010146511A1 (en) 2009-06-17 2010-12-23 Pfizer Limited Treatment of overactive bladder
US9163330B2 (en) 2009-07-13 2015-10-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
IN2012DN00863A (de) 2009-07-31 2015-07-10 Medarex Inc
US8394922B2 (en) 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
GB0914589D0 (en) 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
WO2011029823A1 (en) 2009-09-09 2011-03-17 Novartis Ag Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
GB0916630D0 (en) 2009-09-22 2009-11-04 Secr Defence Antibody
CA2776144C (en) 2009-09-29 2020-10-27 Fraunhofer Usa, Inc. Influenza hemagglutinin antibodies, compositions, and related methods
GB0917817D0 (en) 2009-10-12 2009-11-25 Biotica Tech Ltd Novel compounds and methods for their production
GB0917816D0 (en) 2009-10-12 2009-11-25 Biotica Tech Ltd Novel compounds and methods for their production
US20120231004A1 (en) 2009-10-13 2012-09-13 Oxford Biotherapeutic Ltd. Antibodies
EP2488199A1 (de) 2009-10-14 2012-08-22 Merrimack Pharmaceuticals, Inc. Auf igf-1r- und erbb3-signalisierung gerichtete bispezfische bindemittel und ihre verwendung
CN102655747A (zh) 2009-10-19 2012-09-05 阿米库斯治疗学公司 用于预防和/或治疗中枢神经系统退行性失调的新颖组合物
EP2490533B1 (de) 2009-10-19 2015-09-16 Amicus Therapeutics, Inc. Neue zusammensetzungen zur prävention und/oder behandlung lysosomaler speicherkrankheiten
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
US20120282276A1 (en) 2009-11-05 2012-11-08 The Regents Of The University Of Michigan Biomarkers predictive of progression of fibrosis
US9428586B2 (en) 2009-12-01 2016-08-30 Compugen Ltd Heparanase splice variant
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US20110137260A1 (en) 2009-12-07 2011-06-09 Allergan, Inc. Slotted syringe
US8293718B2 (en) 2009-12-18 2012-10-23 Novartis Ag Organic compositions to treat HSF1-related diseases
TW201130511A (en) 2009-12-22 2011-09-16 Novartis Ag Soluble proteins for use as therapeutics
EP2519517B1 (de) 2009-12-29 2015-03-25 Dana-Farber Cancer Institute, Inc. Typ-ii-raf-kinase-hemmer
WO2011094445A1 (en) 2010-01-27 2011-08-04 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
KR101888026B1 (ko) 2010-02-03 2018-08-13 인피니티 파마슈티컬스, 인코포레이티드 지방산 아미드 하이드롤라제 저해제
KR20120125357A (ko) 2010-02-10 2012-11-14 노파르티스 아게 근육 성장을 위한 방법 및 화합물
CN102844023B (zh) 2010-03-08 2016-01-20 索隆-基特林癌症研究协会 Cdc7激酶抑制剂以及其用途
GB201003922D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Conjugation process
GB201003920D0 (en) 2010-03-09 2010-04-21 Glaxosmithkline Biolog Sa Method of treatment
BR112012023895A2 (pt) 2010-03-17 2016-11-29 Abbott Res Bv composições de anti-fator de crescimento do nervo (ngf)
WO2011119549A1 (en) 2010-03-22 2011-09-29 President And Fellows Of Harvard College Trioxacarcins and uses thereof
EP2371864A1 (de) 2010-03-23 2011-10-05 Ganymed Pharmaceuticals AG Monoklonale Antikörper zur Krebsbehandlung
EP3153521B1 (de) 2010-03-26 2019-09-04 Trustees of Dartmouth College Vista-regulatorisches t-zellen-mediator-protein, vista-bindende wirkstoffe und verwendung davon
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
WO2011130332A1 (en) 2010-04-12 2011-10-20 Academia Sinica Glycan arrays for high throughput screening of viruses
CA2796571C (en) 2010-04-13 2019-10-29 Celldex Therapeutics Inc. Antibodies that bind human cd27 and uses thereof
ES2805873T3 (es) 2010-04-16 2021-02-15 Biogen Ma Inc Anticuerpos anti-VLA-4
US9795658B2 (en) 2010-04-20 2017-10-24 Admedus Vaccines Pty Ltd Expression system for modulating an immune response
KR20180033606A (ko) 2010-04-23 2018-04-03 애로우헤드 파마슈티컬스 인코포레이티드 베타-ＥＮａＣ-관련 질환을 치료하기 위한 유기 조성물
JP2013533211A (ja) 2010-05-04 2013-08-22 メリマック ファーマシューティカルズ インコーポレーティッド 上皮成長因子受容体（ｅｇｆｒ）に対する抗体およびその使用
WO2011140151A1 (en) 2010-05-04 2011-11-10 Dyax Corp. Antibodies against epidermal growth factor receptor (egfr)
EP2566853B1 (de) 2010-05-05 2017-01-25 Infinity Pharmaceuticals, Inc. Tetrazolone als fettsäuresynthasehemmer
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
DK2566953T3 (en) 2010-05-07 2019-04-15 Greenlight Biosciences Inc METHODS OF MANAGING THE POWER BY METABOLIC ROADS USING ENZYMOUS LOCATION
RU2019142507A (ru) 2010-05-11 2020-08-24 Лантеус Медикал Имэджинг, Инк. Композиции, способы и системы для синтеза и применение визуализирующих средств
ES2465594T3 (es) 2010-05-19 2014-06-06 Allergan, Inc. Dispositivo de inyección modular
US9193989B2 (en) 2010-06-18 2015-11-24 Taiho Pharmaceutical Co., Ltd. PRPK-TPRKB modulators and uses thereof
WO2016030888A1 (en) 2014-08-26 2016-03-03 Compugen Ltd. Polypeptides and uses thereof as a drug for treatment of autoimmune disorders
AU2011272941B2 (en) 2010-06-30 2014-05-29 Compugen Ltd. C10RF32 for the treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders
CA2804154C (en) 2010-07-01 2021-06-01 The Texas A&M University System Perlecan domain v protects, repairs and restores ischemic brain stroke injury and motor function
CN103119062A (zh) 2010-07-16 2013-05-22 埃博灵克斯股份有限公司 修饰的单结构域抗原结合分子及其应用
CA2807552A1 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2807685C (en) 2010-08-13 2020-10-06 Aileron Therapeutics, Inc. P53 derived peptidomimetic macrocycle
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
CA2809284C (en) 2010-08-31 2021-02-23 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
AU2011302072B2 (en) * 2010-09-15 2014-05-15 Zogenix, Inc. Needle-free injectors and design parameters thereof that optimize injection performance
US8999335B2 (en) 2010-09-17 2015-04-07 Compugen Ltd. Compositions and methods for treatment of drug resistant multiple myeloma
US8802110B2 (en) 2010-09-21 2014-08-12 Massachusetts Institute Of Technology Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines
US8957026B2 (en) 2010-09-22 2015-02-17 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
US9388230B2 (en) 2010-09-28 2016-07-12 Kahr Medical(2005) Ltd Compositions and methods for treatment of hematological malignancies
ES2862955T3 (es) 2010-10-01 2021-10-08 Modernatx Inc Acidos nucleicos manipulados y métodos de uso de los mismos
EP2621954A1 (de) 2010-10-01 2013-08-07 Oxford Biotherapeutics Ltd. Anti-rori-antikörper
JP2013538856A (ja) 2010-10-01 2013-10-17 バイオジェン・アイデック・エムエイ・インコーポレイテッド 単独治療または他のがん治療と組み合わせたインターフェロンβの使用方法
RU2663718C2 (ru) 2010-10-04 2018-08-08 Массачусетс Инститьют Оф Текнолоджи Полипептиды гемагглютининов, а также связанные с ними реагенты и способы
CN103154037A (zh) 2010-10-05 2013-06-12 诺瓦提斯公司 抗IL12Rβ1抗体及它们在治疗自身免疫病和炎性疾病中的用途
JP2013542788A (ja) 2010-11-03 2013-11-28 コンストラクト メディカル プロプライエタリー リミテッド ポータブル真空装置
CA2817577A1 (en) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US9399764B2 (en) 2010-11-24 2016-07-26 Novartis International Pharmaceutical, Ltd. Fusion enzymes
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
GB201100282D0 (en) 2011-01-07 2011-02-23 Ucb Pharma Sa Biological methods
DK2663309T3 (en) 2011-01-10 2017-06-19 Infinity Pharmaceuticals Inc METHODS FOR PRODUCING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES
WO2012099942A2 (en) 2011-01-19 2012-07-26 Terakine Therapeutics, Inc. Methods and compositions for treating metabolic syndrome
BR112013018920A2 (pt) 2011-01-24 2017-11-28 Anterios Inc composições de nanopartículas, formulações destas e seus usos
JP2014503586A (ja) 2011-01-24 2014-02-13 アンテリオス， インコーポレイテッド 油組成物
CN103747782A (zh) 2011-01-24 2014-04-23 安特里奥公司 纳米颗粒组合物
US8939943B2 (en) 2011-01-26 2015-01-27 Kaleo, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US8627816B2 (en) 2011-02-28 2014-01-14 Intelliject, Inc. Medicament delivery device for administration of opioid antagonists including formulations for naloxone
US9173999B2 (en) 2011-01-26 2015-11-03 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
KR20140010126A (ko) 2011-03-03 2014-01-23 터서스 파마수티칼 엘엘씨 C16:1n7-팔미톨리에이트를 포함하는 조성물들 및 방법들
WO2012119989A2 (en) 2011-03-04 2012-09-13 Oryzon Genomics, S.A. Methods and antibodies for the diagnosis and treatment of cancer
GB201103836D0 (en) 2011-03-07 2011-04-20 Glaxosmithkline Biolog Sa Conjugation process
US9193767B2 (en) 2011-03-30 2015-11-24 Brown University Enopeptins, uses thereof, and methods of synthesis thereto
US20130281932A1 (en) * 2011-03-30 2013-10-24 Ziv Harish Palm-based injector actuation and safety surfaces
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
WO2012140627A1 (en) 2011-04-15 2012-10-18 Compugen Ltd. Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
CN103608065A (zh) * 2011-04-19 2014-02-26 因维希德姆有限责任公司 含过饱和气体物质的生产方法及其透皮给药设备与使用
UY34073A (es) 2011-05-17 2013-01-03 Glaxosmithkline Biolog Sa Vacuna mejorada de streptococcus pneumoniae y métodos de preparación.
US8691231B2 (en) 2011-06-03 2014-04-08 Merrimack Pharmaceuticals, Inc. Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies
AU2012269929A1 (en) 2011-06-16 2013-12-12 Novartis Ag Soluble proteins for use as therapeutics
JP2014527398A (ja) 2011-06-21 2014-10-16 オンコファクター コーポレイション がんの療法および診断のための組成物および方法
CA2840224C (en) 2011-06-22 2019-08-13 The General Hospital Corporation Treatment of proteinopathies
ES2640960T3 (es) 2011-06-28 2017-11-07 Oxford Biotherapeutics Ltd. Anticuerpos para ADP-ribosil ciclasa 2
EP2726503B1 (de) 2011-06-30 2019-09-04 Compugen Ltd. Polypetide und ihre verwendung zur behandlung von autoimmunerkrankungen und infektionen
EP2726099B1 (de) 2011-07-01 2018-07-25 Novartis AG Verfahren zur behandlung von stoffwechselstörungen
MX2014000648A (es) 2011-07-19 2014-09-25 Infinity Pharmaceuticals Inc Compuestos heterociclicos y sus usos.
AU2012284088B2 (en) 2011-07-19 2015-10-08 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
RS58438B1 (sr) 2011-07-22 2019-04-30 Massachusetts Inst Technology Aktivatori klase i histonskih deacetilaza (hdacs) i njihova primena
US10300140B2 (en) 2011-07-28 2019-05-28 I2 Pharmaceuticals, Inc. Sur-binding proteins against ERBB3
KR20140075693A (ko) 2011-08-29 2014-06-19 인피니티 파마슈티칼스, 인코포레이티드 헤테로사이클릭 화합물 및 그의 용도
EA201490553A1 (ru) 2011-09-02 2014-08-29 Новартис Аг Органические композиции для лечения связанных с hsf1 заболеваний
DK2753605T3 (da) 2011-09-09 2019-06-17 Lantheus Medical Imaging Inc Sammensætninger, fremgangsmåder, og systemer til syntesen og anvendelsen af billeddannelsesmidler
JP2014526250A (ja) 2011-09-09 2014-10-06 グリーンライト バイオサイエンシーズ インコーポレーテッド カルバペネムの無細胞調製
EP3384938A1 (de) 2011-09-12 2018-10-10 Moderna Therapeutics, Inc. Manipulierte nukleinsäuren und verfahren zur verwendung davon
WO2013043569A1 (en) 2011-09-20 2013-03-28 Vical Incorporated Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
EA027900B1 (ru) 2011-09-22 2017-09-29 Эмджен Инк. Связывающие антиген cd27l белки
US9630979B2 (en) 2011-09-29 2017-04-25 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
WO2013052523A1 (en) 2011-10-03 2013-04-11 modeRNA Therapeutics Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
RU2474437C1 (ru) * 2011-10-13 2013-02-10 Борис Владимирович Смоляров Способ осуществления безыгольной инъекции
US20130096170A1 (en) 2011-10-14 2013-04-18 Hospira, Inc. Methods of treating pediatric patients using dexmedetomidine
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
PL2776032T3 (pl) 2011-11-09 2019-03-29 Bristol-Myers Squibb Company Zastosowanie przeciwciała anty-cxcr4 w leczeniu nowotworów hematologicznych
EP2822935B1 (de) 2011-11-17 2019-05-15 Dana-Farber Cancer Institute, Inc. Inhibitoren der c-jun-n-terminal-kinase (jnk)
US8603028B2 (en) 2011-11-18 2013-12-10 Allergan, Inc. Injection device having an angled tip portion
GB201120000D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
GB201119999D0 (en) 2011-11-20 2012-01-04 Glaxosmithkline Biolog Sa Vaccine
KR102111176B1 (ko) 2011-12-16 2020-05-15 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 4'-데스페리티오신 유사체의 용도
CN104114572A (zh) 2011-12-16 2014-10-22 现代治疗公司 经修饰的核苷、核苷酸和核酸组合物
US8426471B1 (en) 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
WO2013096828A1 (en) 2011-12-22 2013-06-27 Sea Lane Biotechnologies, Llc Surrogate binding proteins
GB201122305D0 (en) 2011-12-23 2012-02-01 Biotica Tech Ltd Novel compound
US8242158B1 (en) 2012-01-04 2012-08-14 Hospira, Inc. Dexmedetomidine premix formulation
WO2013102674A2 (en) 2012-01-05 2013-07-11 Novartis International Pharmaceutical Ltd. Protease deficient filamentous fungal cells and methods of use thereof
AU2013208720A1 (en) 2012-01-09 2014-07-24 Arrowhead Research Corporation RNAi agents to treat Beta-Catenin related diseases
US10130800B2 (en) 2012-01-27 2018-11-20 Invisiderm, Llc Method of producing substances with supersaturated gas, transdermal delivery device thereof, and uses thereof
WO2013114367A2 (en) 2012-02-01 2013-08-08 Compugen Ltd. C10rf32 antibodies, and uses thereof for treatment of cancer
DK2814829T3 (en) 2012-02-13 2017-03-20 Bristol Myers Squibb Co RELATIONSHIPS, CONJUGATES THEREOF AND USES AND RELATED PROCEDURES
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
MX362492B (es) 2012-02-15 2019-01-21 Aileron Therapeutics Inc Macrociclos peptidomiméticos.
WO2013142796A2 (en) 2012-03-23 2013-09-26 Bristol-Myers Squibb Company Methods of treatments using ctla4 antibodies
US20150050240A1 (en) 2012-03-27 2015-02-19 Novartis Ag Treatment of fibrosis
MX354127B (es) 2012-03-27 2018-02-14 Amicus Therapeutics Inc Compuestos novedosos para prevenir y/o tratar tesaurismosis lisosomicas y/o trastornos degenerativos del sistema nervioso central.
WO2013151697A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
EP2834254A2 (de) 2012-04-06 2015-02-11 President and Fellows of Harvard College Moenomycin-analoga, syntheseverfahren und verwendung
EP2850090B1 (de) 2012-04-06 2018-10-03 President and Fellows of Harvard College Chemoenzymatische verfahren zur synthetisierung von moenomycin-analoga
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
US9181572B2 (en) 2012-04-20 2015-11-10 Abbvie, Inc. Methods to modulate lysine variant distribution
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
US20130304017A1 (en) * 2012-05-09 2013-11-14 Bioject, Inc. Peformance of needle-free injection according to known relationships
BR112014027991A2 (pt) 2012-05-10 2017-07-18 Massachusetts Inst Technology agentes para neutralização de influenza
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
US9399672B2 (en) 2012-05-17 2016-07-26 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Hepatitis C virus neutralizing antibody
UY34813A (es) 2012-05-18 2013-11-29 Amgen Inc Proteínas de unión a antígeno dirigidas contra el receptor st2
US9522235B2 (en) 2012-05-22 2016-12-20 Kaleo, Inc. Devices and methods for delivering medicaments from a multi-chamber container
EP2852610B1 (de) 2012-05-23 2018-07-11 Glykos Finland Oy Herstellung von fucosylierten glykoproteinen
WO2013176754A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Novel purification of antibodies using hydrophobic interaction chromatography
CA2875683A1 (en) 2012-06-05 2013-12-12 The Australian National University Vaccination with interleukin-4 antagonists
GB201210082D0 (en) * 2012-06-07 2012-07-25 Consort Medical Plc Improved syringe
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
WO2014039983A1 (en) 2012-09-07 2014-03-13 The Trustees Of Dartmouth College Vista modulators for diagnosis and treatment of cancer
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
US20140037680A1 (en) 2012-08-06 2014-02-06 Glaxosmithkline Biologicals, S.A. Novel method
WO2014024026A1 (en) 2012-08-06 2014-02-13 Glaxosmithkline Biologicals S.A. Method for eliciting in infants an immune response against rsv and b. pertussis
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US10309430B2 (en) * 2012-08-10 2019-06-04 Confluent Surgical, Inc. Pneumatic actuation assembly
WO2014028463A1 (en) 2012-08-14 2014-02-20 Allergan, Inc. Syringe for mixing and dispensing adipose tissue
CA2880701A1 (en) 2012-08-18 2014-02-27 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014052647A2 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
US20150225471A1 (en) 2012-10-01 2015-08-13 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
ES2719776T3 (es) 2012-10-12 2019-07-16 Broad Inst Inc Inhibidores de GSK3 y métodos de uso de los mismos
EP2909194A1 (de) 2012-10-18 2015-08-26 Dana-Farber Cancer Institute, Inc. Hemmer der cyclinabhängigen kinase 7 (cdk7)
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
US20140114248A1 (en) 2012-10-24 2014-04-24 Nuance Designs, LLC Power pack for an autoinjector
WO2014065822A1 (en) 2012-10-26 2014-05-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hepatitis c virus neutralizing epitopes, antibodies, and methods
DK2914296T4 (da) 2012-11-01 2022-01-03 Infinity Pharmaceuticals Inc Behandling af cancere under anvendelse af PI3-kinase-isoform-modulatorer
EP2914256B1 (de) 2012-11-01 2019-07-31 Aileron Therapeutics, Inc. Disubstituierte aminosäuren und verfahren zur herstellung und verwendung davon
EP2917203B1 (de) 2012-11-02 2019-04-03 Dana-Farber Cancer Institute, Inc. Verfahren zur identifizierung von myc inhibitoren
US10039869B2 (en) * 2012-11-13 2018-08-07 Construct Medical Pty, Ltd. Portable suction device
KR101651448B1 (ko) 2012-11-21 2016-08-26 토포카인 쎄라퓨틱스, 인코포레이티드 체지방을 국소적으로 증가시키는 방법 및 조성물
PL2922554T3 (pl) 2012-11-26 2022-06-20 Modernatx, Inc. Na zmodyfikowany na końcach
JP6408478B2 (ja) 2012-11-26 2018-10-17 プレジデント アンド フェローズ オブ ハーバード カレッジ トリオキサカルシン、トリオキサカルシン−抗体複合体、およびその用途
PT2928923T (pt) 2012-12-10 2020-03-27 Biogen Ma Inc Anticorpos antígenos 2 de células dendríticas anti-sangue e os seus usos
EP3626735A1 (de) 2012-12-18 2020-03-25 Novartis AG Stabilisierte insulinähnliche wachstumsfaktorpolypeptide
US9745291B2 (en) 2012-12-21 2017-08-29 Epizyme, Inc. PRMT5 inhibitors containing a dihydro- or tetrahydroisoquinoline and uses thereof
MX2015008052A (es) 2012-12-21 2016-08-18 Epizyme Inc Inhibidores de prmt5 y sus usos.
WO2014100695A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. Prmt5 inhibitors and uses thereof
JP2016505001A (ja) 2012-12-21 2016-02-18 エピザイム，インコーポレイティド Ｐｒｍｔ５阻害剤およびその使用
CA2896708A1 (en) 2012-12-27 2014-07-03 Kaleo, Inc. Devices, systems and methods for locating and interacting with medicament delivery systems
EP2946014A2 (de) 2013-01-17 2015-11-25 Moderna Therapeutics, Inc. Signal-sensor-polynukleotide zur veränderung zellulärer phänotypen
JO3519B1 (ar) 2013-01-25 2020-07-05 Amgen Inc تركيبات أجسام مضادة لأجل cdh19 و cd3
ES2728936T3 (es) 2013-01-25 2019-10-29 Amgen Inc Anticuerpos dirigidos contra CDH19 para melanoma
US20140335504A1 (en) 2013-02-07 2014-11-13 Massachusetts Institute Of Technology Human adaptation of h5 influenza
CA2900008A1 (en) 2013-02-07 2014-08-14 Children's Medical Center Corporation Protein antigens that provide protection against pneumococcal colonization and/or disease
CA2897682C (en) 2013-02-08 2023-03-14 Novartis Ag Anti-il-17a antibodies and their use in treating autoimmune and inflammatory disorders
CN105073139B (zh) 2013-02-14 2019-01-11 百时美施贵宝公司 妥布赖森化合物、制备和使用方法
JP6416793B2 (ja) 2013-02-28 2018-10-31 カプリオン プロテオミクス インコーポレーテッド 結核のバイオマーカー及びその使用
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
US10081654B2 (en) 2013-03-13 2018-09-25 President And Fellows Of Harvard College Stapled and stitched polypeptides and uses thereof
US9580486B2 (en) 2013-03-14 2017-02-28 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
SG11201504260UA (en) 2013-03-14 2015-10-29 Abbvie Inc Low acidic species compositions and methods for producing and using the same
CA2899449A1 (en) 2013-03-14 2014-10-02 Abbvie Inc. Low acidic species compositions and methods for producing the same using displacement chromatography
US10035859B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
SI2970449T1 (sl) 2013-03-15 2019-11-29 Amgen Res Munich Gmbh Enoverižne vezavne molekule, ki vsebujejo N-terminalni ABP
EP2970194A1 (de) 2013-03-15 2016-01-20 Infinity Pharmaceuticals, Inc. Salze und feste formen von isochinolinonen und zusammensetzung damit sowie verfahren zur verwendung davon
EP2970446A1 (de) 2013-03-15 2016-01-20 Amgen Research (Munich) GmbH Antikörperkonstrukte für influenza m2 und cd3
US10035860B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
EA201591806A1 (ru) 2013-03-15 2016-01-29 Байоджен Ма Инк. Лечение и профилактика острой почечной недостаточности с применением анти-альфа-v-бета-5 антител
KR102233251B1 (ko) 2013-04-03 2021-03-26 엔-폴드 엘엘씨 신규 나노입자 조성물
EP2988597B1 (de) 2013-04-04 2022-06-08 President and Fellows of Harvard College Makrolide sowie verfahren zu deren herstellung und verwendung
ES2774330T3 (es) 2013-04-09 2020-07-20 Massachusetts Inst Technology Polímero de suministro de fármaco y usos del mismo
WO2014179464A1 (en) 2013-04-30 2014-11-06 Massachusetts Institute Of Technology Human adaptation of h3 influenza
WO2014179562A1 (en) 2013-05-01 2014-11-06 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
NO2753788T3 (de) 2013-05-10 2018-06-16
WO2014186504A1 (en) 2013-05-15 2014-11-20 Topokine Therapeutics, Inc. Methods and compositions for topical delivery of prostaglandins to subcutaneous fat
US20140350516A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Mechanical syringe accessory
US20140350518A1 (en) 2013-05-23 2014-11-27 Allergan, Inc. Syringe extrusion accessory
DK3003309T3 (da) 2013-05-30 2020-12-14 Infinity Pharmaceuticals Inc Behandling af cancer med PI3-kinase-isoform modulatorer
PL3004167T3 (pl) 2013-05-30 2019-01-31 Kiniksa Pharmaceuticals, Ltd. Białka wiążące antygen receptora onkostatyny m
US10526375B2 (en) 2013-06-05 2020-01-07 Massachusetts Institute Of Technology Human Adaptation of H7 HA
US9212145B2 (en) 2013-06-11 2015-12-15 Kala Pharmaceuticals, Inc. Urea derivatives and uses thereof
AU2014278005B2 (en) 2013-06-14 2018-11-22 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
ES2909438T3 (es) 2013-06-26 2022-05-06 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh Enantiómero (S) de mepacina como inhibidor de paracaspasa (MALT1) para tratar cáncer
WO2014210397A1 (en) 2013-06-26 2014-12-31 Academia Sinica Rm2 antigens and use thereof
US9981030B2 (en) 2013-06-27 2018-05-29 Academia Sinica Glycan conjugates and use thereof
EP3024327B1 (de) 2013-07-25 2019-09-04 Dana-Farber Cancer Institute, Inc. Hemmer von transkriptionsfaktoren und verwendungen davon
WO2015021058A2 (en) 2013-08-05 2015-02-12 Greenlight Biosciences, Inc. Engineered proteins with a protease cleavage site
EP3030260A1 (de) 2013-08-05 2016-06-15 GlaxoSmithKline Biologicals S.A. Immunogene kombinationszusammensetzungen
TWI532511B (zh) * 2013-08-16 2016-05-11 京華堂實業股份有限公司 無針型注射系統及其注射方法
CA2923579C (en) 2013-09-06 2023-09-05 Academia Sinica Human inkt cell activation using glycolipids with altered glycosyl groups
AR097648A1 (es) 2013-09-13 2016-04-06 Amgen Inc Combinación de factores epigenéticos y compuestos biespecíficos que tienen como diana cd33 y cd3 en el tratamiento de leucemia mieloide
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
AU2014330853A1 (en) 2013-10-02 2016-02-25 National Institutes Of Health Insulin-like growth factor mimetics for use in therapy
NZ718430A (en) 2013-10-04 2021-12-24 Infinity Pharmaceuticals Inc Heterocyclic compounds and uses thereof
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2015051234A2 (en) 2013-10-04 2015-04-09 Biogen Idec Ma Inc. Tweak antagonists for treating lupus nephritis and muscle atrophy
DK3055331T3 (da) 2013-10-11 2021-03-22 Oxford Bio Therapeutics Ltd Konjugerede antistoffer mod ly75 til cancerbehandling
WO2015057894A1 (en) 2013-10-15 2015-04-23 Massachusetts Institute Of Technology Methods for treating polycystic kidney disease and polycystic liver disease
US9902986B2 (en) 2013-10-16 2018-02-27 Massachusetts Institute Of Technology Enterobactin conjugates and uses thereof
JP6491202B2 (ja) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の多環阻害剤
WO2015057939A1 (en) 2013-10-18 2015-04-23 Biogen Idec Ma Inc. Anti-s1p4 antibodies and uses thereof
WO2015058126A1 (en) 2013-10-18 2015-04-23 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
US20160244452A1 (en) 2013-10-21 2016-08-25 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2014342042B2 (en) 2013-11-01 2017-08-17 KALA BIO, Inc. Crystalline forms of therapeutic compounds and uses thereof
UY35874A (es) 2013-12-12 2015-07-31 Novartis Ag Un proceso para la preparación de una composición de proteínas pegiladas
JP6622703B2 (ja) 2013-12-20 2019-12-18 インターベット インターナショナル ベー． フェー． アンタゴニストの、抗イヌｐｄ−１抗体
TWI670283B (zh) 2013-12-23 2019-09-01 美商建南德克公司 抗體及使用方法
CN106103452B (zh) 2013-12-24 2019-05-21 哈佛学院院长等 皮质抑素类似物及其合成和用途
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
CN106661107B (zh) 2013-12-24 2021-12-24 杨森制药公司 抗vista抗体及片段
TW201620939A (zh) 2014-01-16 2016-06-16 中央研究院 治療及檢測癌症之組合物及方法
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
US10793571B2 (en) 2014-01-31 2020-10-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
EP3105235B1 (de) 2014-02-12 2019-11-06 Amicus Therapeutics, Inc. Zuckerderivate mit schwefelhaltigen gruppen und verfahren zur herstellung davon und verfahren zur verwendung davon zur behandlung von mps iiic
WO2015134920A1 (en) 2014-03-07 2015-09-11 The Arizona Board Of Regents On Behalf Of The University Of Arizona Non-narcotic crmp2 peptides targeting sodium channels for chronic pain
EA201691872A1 (ru) 2014-03-19 2017-04-28 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств
JP6562942B2 (ja) 2014-03-27 2019-08-28 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 反応性標識化合物およびその使用
CN106456735B (zh) 2014-03-28 2021-06-29 华盛顿大学商业中心 乳腺癌和卵巢癌疫苗
US9675627B2 (en) 2014-04-14 2017-06-13 Amicus Therapeutics, Inc. Dosing regimens for treating and/or preventing cerebral amyloidoses
US10017477B2 (en) 2014-04-23 2018-07-10 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015168079A1 (en) 2014-04-29 2015-11-05 Infinity Pharmaceuticals, Inc. Pyrimidine or pyridine derivatives useful as pi3k inhibitors
US10039816B2 (en) 2014-04-30 2018-08-07 Massachusetts Institute Of Technology Siderophore-based immunization against gram-negative bacteria
US10029048B2 (en) 2014-05-13 2018-07-24 Allergan, Inc. High force injection devices
WO2015179635A2 (en) 2014-05-21 2015-11-26 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
AU2015267045B2 (en) 2014-05-27 2021-02-25 Academia Sinica Anti-HER2 glycoantibodies and uses thereof
WO2015184008A1 (en) 2014-05-27 2015-12-03 Academia Sinica Fucosidase from bacteroides and methods using the same
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
JP2017518989A (ja) 2014-05-27 2017-07-13 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 抗ｃｄ２０糖操作抗体群およびその使用
TWI732738B (zh) 2014-05-28 2021-07-11 中央研究院 抗TNF-α醣抗體及其用途
JP6612017B2 (ja) * 2014-06-03 2019-11-27 株式会社ダイセル 無針注射器による注射システム
EP3151921B1 (de) 2014-06-06 2019-08-28 Bristol-Myers Squibb Company Antikörper gegen glucocorticoidinduzierten tumornekrosefaktorrezeptor (gitr) und verwendungen davon
JP6997619B2 (ja) 2014-06-11 2022-01-17 キャシー・エイ・グリーン 液性免疫の抑制または増進のための、ｖｉｓｔａアゴニスト及びｖｉｓｔａアンタゴニストの使用
JP6664338B2 (ja) 2014-06-13 2020-03-13 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組合せ物
CN106559991B (zh) 2014-06-19 2019-09-20 阿里亚德医药股份有限公司 用于激酶抑制的杂芳基化合物
EP2959931A1 (de) 2014-06-24 2015-12-30 LTS LOHMANN Therapie-Systeme AG Nadellose Injektionsvorrichtung
US20170291939A1 (en) 2014-06-25 2017-10-12 Novartis Ag Antibodies specific for il-17a fused to hyaluronan binding peptide tags
WO2015200425A1 (en) 2014-06-27 2015-12-30 Topokine Therapeutics, Inc. Topical dosage regimen
EP3164379A1 (de) 2014-07-02 2017-05-10 Massachusetts Institute of Technology Lipidoide aus polyaminfettsäure und verwendungen davon
US20170226552A1 (en) 2014-07-03 2017-08-10 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using cobalt
WO2016007764A1 (en) 2014-07-09 2016-01-14 Abbvie Inc. Methods for modulating the glycosylation profile of recombinant proteins using non-commonly used sugars
WO2016011386A1 (en) 2014-07-18 2016-01-21 University Of Washington Cancer vaccine compositions and methods of use thereof
US9517307B2 (en) 2014-07-18 2016-12-13 Kaleo, Inc. Devices and methods for delivering opioid antagonists including formulations for naloxone
TW201609811A (zh) 2014-07-31 2016-03-16 安美基研究（慕尼黑）公司 具有增強之組織分布之雙特異性單鏈抗體構築體
MX2017001401A (es) 2014-07-31 2017-08-07 Amgen Res (Munich) Gmbh Constructos de anticuerpos de cadena sencilla biespecifica especificos para especies cruzadas optimizadas.
AR101669A1 (es) 2014-07-31 2017-01-04 Amgen Res (Munich) Gmbh Constructos de anticuerpos para cdh19 y cd3
EP2979714A1 (de) 2014-08-02 2016-02-03 LTS LOHMANN Therapie-Systeme AG Nadellose Injektionsvorrichtung aufweisend eine Membran
CA2958018A1 (en) 2014-08-11 2016-02-18 University Of Massachusetts Anti-ospa antibodies and methods of use
US10736966B2 (en) 2014-08-12 2020-08-11 Massachusetts Institute Of Technology Brush-poly (glycoamidoamine)-lipids and uses thereof
JO3663B1 (ar) 2014-08-19 2020-08-27 Merck Sharp & Dohme الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
AP2017009765A0 (en) 2014-08-19 2017-02-28 Merck Sharp & Dohme Anti-tigit antibodies
CA2960712A1 (en) 2014-09-08 2016-03-17 Academia Sinica Human inkt cell activation using glycolipids
EP2993174A1 (de) 2014-09-08 2016-03-09 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH Pyrazolopyridinderivate und deren Verwendung in der Therapie
CN107106642B (zh) 2014-09-24 2021-02-26 艾瑞朗医疗公司 拟肽大环化合物及其制剂
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10226585B2 (en) 2014-10-01 2019-03-12 Allergan, Inc. Devices for injection and dosing
US9708348B2 (en) 2014-10-03 2017-07-18 Infinity Pharmaceuticals, Inc. Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof
AU2015327819B2 (en) 2014-10-03 2021-07-01 Massachusetts Institute Of Technology Antibodies that bind ebola glycoprotein and uses thereof
US9732119B2 (en) 2014-10-10 2017-08-15 Bristol-Myers Squibb Company Immunomodulators
AU2015335950B2 (en) 2014-10-21 2018-01-25 Takeda Pharmaceutical Company Limited Crystalline forms of 5-chloro-N4-[-2-(dimethylphosphoryl) phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl) piperidin-1-yl] phenyl}pyrimidine-2,4-diamine
EP3011988A1 (de) 2014-10-22 2016-04-27 LTS LOHMANN Therapie-Systeme AG Nadellose Injektionsvorrichtung aufweisend ein Gel und eine Membran
JP2017533238A (ja) 2014-10-28 2017-11-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 抗原特異的寛容のための組成物及び方法
WO2016075137A1 (en) 2014-11-10 2016-05-19 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death
US10077287B2 (en) 2014-11-10 2018-09-18 Bristol-Myers Squibb Company Tubulysin analogs and methods of making and use
WO2016077125A1 (en) 2014-11-10 2016-05-19 Moderna Therapeutics, Inc. Alternative nucleic acid molecules containing reduced uracil content and uses thereof
US9856292B2 (en) 2014-11-14 2018-01-02 Bristol-Myers Squibb Company Immunomodulators
HUE052526T2 (hu) 2014-11-21 2021-05-28 Bristol Myers Squibb Co Antitestek, amelyek tartalmaznak módosított nehéz konstans régiókat
TWI758928B (zh) 2014-11-21 2022-03-21 美商必治妥美雅史谷比公司 抗cd73抗體及其用途
WO2016086026A1 (en) 2014-11-26 2016-06-02 Kala Pharmaceuticals, Inc. Crystalline forms of a therapeutic compound and uses thereof
EP3227341A1 (de) 2014-12-02 2017-10-11 CeMM - Forschungszentrum für Molekulare Medizin GmbH Anti-mutante calreticulin-antikörper und deren verwendung bei der diagnose und therapie von myeloiden malignomen
AU2015357463B2 (en) 2014-12-05 2021-10-07 Immunext, Inc. Identification of VSIG8 as the putative vista receptor and its use thereof to produce vista/VSIG8 modulators
US10174022B2 (en) 2014-12-10 2019-01-08 Kala Pharmaceuticals, Inc. 1-amino-triazolo(1,5-A)pyridine-substituted urea derivative and uses thereof
US9861680B2 (en) 2014-12-18 2018-01-09 Bristol-Myers Squibb Company Immunomodulators
PL3233912T3 (pl) 2014-12-19 2021-12-27 Regenesance B.V. Przeciwciała, które wiążą ludzkie c6 oraz ich zastosowania
US10314815B2 (en) 2014-12-23 2019-06-11 Sloan-Kettering Institute For Cancer Research Polymorph of granaticin B
US10870651B2 (en) 2014-12-23 2020-12-22 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
CA2971732A1 (en) 2014-12-23 2016-06-30 Bristol-Myers Squibb Company Antibodies to tigit
CN114478773A (zh) 2015-01-09 2022-05-13 阿达尔塔有限公司 Cxcr4结合分子
AU2016206808A1 (en) 2015-01-14 2017-08-31 Bristol-Myers Squibb Company Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
JP6779887B2 (ja) 2015-01-24 2020-11-04 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ 新規なグリカンコンジュゲートおよびその使用方法
US20160222060A1 (en) 2015-02-04 2016-08-04 Bristol-Myers Squibb Company Immunomodulators
US10983128B2 (en) 2015-02-05 2021-04-20 Bristol-Myers Squibb Company CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy
WO2016144773A1 (en) 2015-03-06 2016-09-15 Abbvie Inc. Arabinosylated glycoproteins
US20180044429A1 (en) 2015-03-09 2018-02-15 Celldex Therapeutics, Inc. Cd27 agonists
CN107530490B (zh) 2015-03-10 2021-06-25 爱力根销售有限责任公司 多针注射器
US9809625B2 (en) 2015-03-18 2017-11-07 Bristol-Myers Squibb Company Immunomodulators
AU2016235424A1 (en) 2015-03-20 2017-10-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US20180071380A1 (en) 2015-03-20 2018-03-15 The Regents Of The University Of Michigan Immunogenic compositions for use in vaccination against bordetella
CA2980004C (en) 2015-03-24 2023-10-10 Kaleo, Inc. Devices and methods for delivering a lyophilized medicament
JP6861166B2 (ja) 2015-03-27 2021-04-21 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼの阻害剤
EP3277808A4 (de) 2015-03-30 2019-05-22 Greenlight Biosciences, Inc. Zellfreie herstellung von ribonukleinsäure
CA2980087A1 (en) 2015-04-02 2016-10-06 Intervet International B.V. Antibodies to canine interleukin-4 receptor alpha
WO2016164937A2 (en) 2015-04-10 2016-10-13 Amgen Inc. Interleukin-2 muteins for the expansion of t-regulatory cells
CA2979826A1 (en) 2015-04-10 2016-10-13 Ruth Brack-Werner Pyrone derivatives for use in therapy
CR20170510A (es) 2015-04-10 2018-02-26 Amgen Inc Muteínas de interuquina 2 para la expansión de células t regulatorias
DK3283524T3 (da) 2015-04-17 2023-05-30 Amgen Res Munich Gmbh BISPECIFIKKE ANTISTOFKONSTRUKTIONER MOD CDH3 og CD3
EP3288557A4 (de) 2015-04-27 2018-11-07 University of Florida Research Foundation, Inc. Metabolisch programmierte metallchelatoren und verwendungen davon
KR20170138570A (ko) 2015-04-30 2017-12-15 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 대사 장애를 치료하기 위한 항-aP2 항체 및 항원 결합 물질
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
CA2985816A1 (en) 2015-05-15 2016-11-24 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor superfamily antibodies
EP3297676A2 (de) 2015-05-22 2018-03-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Kombination aus trpm8-agonist und nachr-agonist zur behandlung von obesitas und verwandten erkrankungen sowie zur gewichtsreduzierung
MA47395A (fr) 2015-05-27 2019-12-11 Ucb Biopharma Sprl Méthode pour le traitement d'une maladie neurologique
WO2016196895A1 (en) * 2015-06-05 2016-12-08 Joslin Diabetes Center, Inc. Methods amd compositions for promoting thermogenic potential
US10702527B2 (en) 2015-06-12 2020-07-07 Dana-Farber Cancer Institute, Inc. Combination therapy of transcription inhibitors and kinase inhibitors
CN107847668A (zh) * 2015-06-15 2018-03-27 纽昂斯设计康涅狄格有限责任公司 带有气流调节器的气体促动式自动注射器
JP2017000667A (ja) 2015-06-16 2017-01-05 国立大学法人三重大学 無針注射器及びそれを用いた注射対象領域へのｄｎａ導入方法
HRP20230494T1 (hr) 2015-06-19 2023-08-04 Massachusetts Institute Of Technology Alkenil supstituirani 2,5-piperazindioni i njihova upotreba u pripravcima za isporuku sredstva subjektu ili stanici
CN107922497B (zh) 2015-06-24 2022-04-12 詹森药业有限公司 抗vista抗体和片段
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
EA201890162A1 (ru) 2015-06-29 2018-07-31 Бристол-Маерс Сквибб Компани Антитела к cd40 с повышенной агонистической активностью
CA2990950A1 (en) 2015-06-30 2017-01-05 Kaleo, Inc. Auto-injectors for administration of a medicament within a prefilled syringe
WO2017004548A1 (en) 2015-07-01 2017-01-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US20180305451A1 (en) 2015-07-13 2018-10-25 Compugen Ltd. Hide1 compositions and methods
TWI717375B (zh) 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Ｃｄ７０及ｃｄ３抗體構築體
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Ｍｓｌｎ及ｃｄ３抗體構築體
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
TW202346349A (zh) 2015-07-31 2023-12-01 德商安美基研究（慕尼黑）公司 Dll3及cd3抗體構築體
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
JO3620B1 (ar) 2015-08-05 2020-08-27 Amgen Res Munich Gmbh مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم
US10179128B2 (en) 2015-08-31 2019-01-15 Amicus Therapeutics, Inc. Regimens for treating and preventing lysosomal disorders and degenerative disorders of the central nervous system
EP3347018B1 (de) 2015-09-09 2021-09-01 Dana-Farber Cancer Institute, Inc. Hemmer von cyclinabhängigen kinasen
EP3347372A4 (de) 2015-09-10 2019-09-04 Aileron Therapeutics, Inc. Peptidomimetische makrocyclen als modulatoren von mcl-1
HRP20220156T1 (hr) 2015-09-17 2022-04-15 Modernatx, Inc. Spojevi i pripravci za unutarstaničnu isporuku terapeutskih sredstava
DK3350333T3 (da) 2015-09-17 2022-01-31 Modernatx Inc Polynukleotider, der indeholder en stabiliserende haleregion
RU2638457C2 (ru) 2015-09-28 2017-12-13 Общество С Ограниченной Ответственностью "Онкомакс" Антитела, специфически связывающие рецептор 1 типа фактора роста фибробластов, применение антител для лечения онкологического заболевания, способ получения антител
US11266730B2 (en) 2015-09-29 2022-03-08 The General Hospital Corporation Methods of treating and diagnosing disease using biomarkers for BCG therapy
EP3355905A1 (de) 2015-09-30 2018-08-08 Rhythm Pharmaceuticals, Inc. Verfahren zur behandlung von mit dem melanocortin-4 rezeptor-signalweg assoziierten erkrankungen
EP3355882A1 (de) 2015-10-01 2018-08-08 Kythera Biopharmaceuticals, Inc. Zusammensetzungen mit einem statin zur verwendung in verfahren zur adipolyse
GB201518684D0 (en) 2015-10-21 2015-12-02 Glaxosmithkline Biolog Sa Vaccine
JO3555B1 (ar) 2015-10-29 2020-07-05 Merck Sharp & Dohme جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري
WO2017079768A1 (en) 2015-11-08 2017-05-11 Genentech, Inc. Methods of screening for multispecific antibodies
EP3374390A1 (de) 2015-11-13 2018-09-19 Visterra, Inc. Zusammensetzungen und verfahren zur behandlung und vorbeugung von grippe
AU2016356780A1 (en) 2015-11-19 2018-06-28 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
AR108824A1 (es) 2015-11-21 2018-10-03 Fundacio Privada Inst De Recerca De La Sida Caixa Irsicaixa Derivados de anticuerpos contra el vih con actividad dual antiviral e inmunomodulatoria
EP3383920B1 (de) 2015-11-30 2024-01-10 The Regents of the University of California Freisetzung von tumorspezifischer nutzlast und immunaktivierung mit einem menschlichen antikörper gegen hochspezifisches tumorzellenoberflächenantigen
US10556948B2 (en) 2015-11-30 2020-02-11 Bristol-Myers Squibb Company IP-10 antibodies and their uses
JP7110108B2 (ja) 2015-12-09 2022-08-01 ジンガン メディスン（オーストラリア） プロプライアタリー リミティド 治療用免疫調節組成物
DK3394030T3 (da) 2015-12-22 2022-03-28 Modernatx Inc Forbindelser og sammensætninger til intracellulær afgivelse af midler
RU2021129189A (ru) 2016-01-22 2021-11-15 Мерк Шарп И Доум Корп. Антитела против фактора свертывания xi
TWI797073B (zh) 2016-01-25 2023-04-01 德商安美基研究（慕尼黑）公司 包含雙特異性抗體建構物之醫藥組合物
EA039859B1 (ru) 2016-02-03 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
MX2018009386A (es) 2016-02-03 2018-11-09 Amgen Res Munich Gmbh Constructos de anticuerpo biespecificos para psma y cd3 que se ligan a celulas t.
KR20180103084A (ko) 2016-02-03 2018-09-18 암젠 리서치 (뮌헨) 게엠베하 Bcma 및 cd3 이중특이성 t 세포 맞물림 항체 작제물
EP3413910A1 (de) 2016-02-12 2018-12-19 Janssen Pharmaceutica NV Anti-vista (b7h5)-antikörper
SG11201805941WA (en) 2016-02-17 2018-09-27 Novartis Ag Tgfbeta 2 antibodies
JP7104629B2 (ja) 2016-02-24 2022-07-21 ビステラ， インコーポレイテッド インフルエンザウイルスに対する抗体分子の製剤
US20190284293A1 (en) 2016-03-04 2019-09-19 Bristol-Myers Squibb Company Combination therapy with anti-cd73 antibodies
MX2018010672A (es) 2016-03-04 2019-05-27 Univ Rockefeller Anticuerpos para cumulo de diferenciación 40 (cd40) con actividad agonista mejorada.
US10143746B2 (en) 2016-03-04 2018-12-04 Bristol-Myers Squibb Company Immunomodulators
CN109195996A (zh) 2016-03-08 2019-01-11 中央研究院 N-聚醣及其阵列的模组化合成方法
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
JP6910075B2 (ja) 2016-03-28 2021-07-28 イコル メディカル システムズ，インク． 治療薬の送達のための方法および装置
US10358463B2 (en) 2016-04-05 2019-07-23 Bristol-Myers Squibb Company Immunomodulators
US10954541B2 (en) 2016-04-06 2021-03-23 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
AU2017246114B2 (en) 2016-04-08 2022-03-17 Allergan, Inc. Aspiration and injection device
UA125382C2 (uk) 2016-04-15 2022-03-02 Імьюнекст Інк. Антитіла проти людського vista та їх застосування
US20190255143A1 (en) 2016-04-18 2019-08-22 The Trustees Of Columbia University In The City Of New York Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (nash)
SG11201808821WA (en) 2016-04-18 2018-11-29 Celldex Therapeutics Inc Agonistic antibodies that bind human cd40 and uses thereof
JOP20170091B1 (ar) 2016-04-19 2021-08-17 Amgen Res Munich Gmbh إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية
US20190153425A1 (en) 2016-04-22 2019-05-23 Biontech Rna Pharmaceuticals Gmbh Methods for Providing Single-Stranded RNA
ES2886966T3 (es) * 2016-04-29 2021-12-21 Altaviz Llc Jeringa autoalimentada
KR102417687B1 (ko) 2016-05-09 2022-07-07 브리스톨-마이어스 스큅 컴퍼니 Tl1a 항체 및 그의 용도
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
CN115746107A (zh) 2016-06-03 2023-03-07 圣诺菲·帕斯图尔公司 经改造的流感血凝素多肽的修饰
WO2017214337A1 (en) 2016-06-07 2017-12-14 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US10676536B2 (en) 2016-06-14 2020-06-09 Merck Sharp & Dohme Corp. Anti-coagulation factor XI antibodies
JP2019525901A (ja) 2016-06-14 2019-09-12 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． 脂質ナノ粒子の安定化製剤
US20180002417A1 (en) 2016-06-15 2018-01-04 Celimmune Llc Methods and Compositions for the Treatment of Celiac Disease, Non-Celiac Gluten Sensitivity, and Refractory Celiac Disease
GB201610599D0 (en) 2016-06-17 2016-08-03 Glaxosmithkline Biologicals Sa Immunogenic Composition
US10328205B2 (en) * 2016-07-07 2019-06-25 Shl Medical Ag Drug delivery device with pneumatic power pack
CN117683135A (zh) 2016-07-14 2024-03-12 百时美施贵宝公司 针对tim3的抗体及其用途
US11285191B2 (en) 2016-07-26 2022-03-29 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Immunostimulatory compositions and uses therefor
US20180028755A1 (en) * 2016-07-28 2018-02-01 Portal Instruments, Inc. Connected health platform including needle-free injector system
NL2017267B1 (en) 2016-07-29 2018-02-01 Aduro Biotech Holdings Europe B V Anti-pd-1 antibodies
NL2017270B1 (en) 2016-08-02 2018-02-09 Aduro Biotech Holdings Europe B V New anti-hCTLA-4 antibodies
WO2018027042A1 (en) 2016-08-03 2018-02-08 Bio-Techne Corporation Identification of vsig3/vista as a novel immune checkpoint and use thereof for immunotherapy
NL2017294B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Natural cryptic exon removal by pairs of antisense oligonucleotides.
MX2019001341A (es) 2016-08-05 2019-07-04 Sanofi Pasteur Inc Composicion de conjugado de polisacarido neumococico multivalente-proteina.
CN109862908B (zh) 2016-08-05 2023-05-02 圣诺菲·帕斯图尔公司 多价肺炎球菌多糖-蛋白质缀合物组合物
CN109641911B (zh) 2016-08-19 2023-02-21 百时美施贵宝公司 seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法
CA3034057A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
WO2018035710A1 (en) 2016-08-23 2018-03-01 Akeso Biopharma, Inc. Anti-ctla4 antibodies
US10981976B2 (en) 2016-08-31 2021-04-20 University Of Rochester Human monoclonal antibodies to human endogenous retrovirus K envelope (HERV-K) and use thereof
JOP20190055A1 (ar) 2016-09-26 2019-03-24 Merck Sharp & Dohme أجسام مضادة ضد cd27
EP3305781A1 (de) 2016-10-07 2018-04-11 Deutsches Krebsforschungszentrum Chemische substanzen welche die enzymatische aktivität der humanen kallikrein-related peptidase 6 (klk6) hemmen.
CR20210094A (es) 2016-10-13 2021-03-31 Massachusetts Inst Technology ANTICUERPOS QUE SE UNEN A LA PROTEÍNA DE ENVOLTURA DEL VIRUS ZIKA Y USOS DE LOS MISMOS (Divisional 2019-0193)
AU2017348365A1 (en) 2016-10-28 2019-05-23 Astute Medical, Inc. Use of antibodies to TIMP-2 for the improvement of renal function
JP7085545B2 (ja) 2016-11-07 2022-06-16 ブリストル－マイヤーズ スクイブ カンパニー 免疫修飾因子
WO2018089540A1 (en) 2016-11-08 2018-05-17 Modernatx, Inc. Stabilized formulations of lipid nanoparticles
CA3043277A1 (en) 2016-11-11 2018-05-17 The Regents Of The University Of California Anti-cd46 antibodies and methods of use
US10857150B2 (en) 2016-11-18 2020-12-08 Abliva Ab Use of sanglifehrin macrocyclic analogues as anticancer compounds
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
JP2020502218A (ja) 2016-12-21 2020-01-23 メレオ バイオファーマ ３ リミテッド 骨形成不全症の処置における抗スクレロスチン抗体の使用
KR20220051269A (ko) 2016-12-21 2022-04-26 메레오 바이오파마 3 리미티드 불완전 골형성증 치료에서의 항-스클레로스틴 항체의 용도
IL267538B1 (en) 2016-12-23 2024-01-01 Novartis Ag Antibodies against factor XI and methods for use in preventing, treating, managing or reducing the risk of thromboembolic disorder or stroke in a patient
WO2018119218A1 (en) 2016-12-23 2018-06-28 Kaleo, Inc. Medicament delivery device and methods for delivering drugs to infants and children
US11839604B2 (en) 2016-12-31 2023-12-12 Bioxcel Therapeutics, Inc. Use of sublingual dexmedetomidine for the treatment of agitation
DK3565579T3 (da) 2017-01-05 2023-09-04 Kahr Medical Ltd Pd1-41bbl-fusionsprotein og fremgangsmåder til anvendelse deraf
HRP20220230T1 (hr) 2017-01-05 2022-04-29 Kahr Medical Ltd. Sirp1 alfa-41bbl fuzijski protein i metoda njegove upotrebe
TW201833140A (zh) 2017-01-09 2018-09-16 美商莫瑞麥克製藥公司 抗fgfr抗體及使用方法
WO2018136413A2 (en) 2017-01-17 2018-07-26 Kaleo, Inc. Medicament delivery devices with wireless connectivity and event detection
JP7252526B2 (ja) 2017-01-23 2023-04-05 スチョー アルファマブ カンパニー リミテッド Ｐｄ－ｌ１結合ポリペプチド又は化合物
WO2018140510A1 (en) 2017-01-25 2018-08-02 Biogen Ma Inc. Compositions and methods for treatment of stroke and other cns disorders
JOP20190189A1 (ar) 2017-02-02 2019-08-01 Amgen Res Munich Gmbh تركيبة صيدلانية ذات درجة حموضة منخفضة تتضمن بنيات جسم مضاد يستهدف الخلية t
GB2559553B (en) * 2017-02-06 2021-10-13 Consort Medical Plc A medicament delivery device
GB201702144D0 (en) 2017-02-09 2017-03-29 Annexin Pharmaceuticals Ab Therapeutic compositions
WO2018148508A1 (en) 2017-02-10 2018-08-16 Mount Tam Biotechnologies, Inc. Rapamycin analog
SG11201906947SA (en) 2017-02-17 2019-08-27 Bristol Myers Squibb Co Antibodies to alpha-synuclein and uses thereof
GB201703876D0 (en) 2017-03-10 2017-04-26 Berlin-Chemie Ag Pharmaceutical combinations
RS63953B1 (sr) 2017-03-15 2023-02-28 Modernatx Inc Jedinjenje i kompozicije za intracelularnu isporuku terapeutskih sredstava
JP7332478B2 (ja) 2017-03-15 2023-08-23 モデルナティエックス インコーポレイテッド 脂質ナノ粒子製剤
US11555031B2 (en) 2017-03-20 2023-01-17 The Broad Institute, Inc. Compounds and methods for regulating insulin secretion
USD867582S1 (en) 2017-03-24 2019-11-19 Allergan, Inc. Syringe device
KR20190136063A (ko) 2017-04-05 2019-12-09 더 브로드 인스티튜트, 인코퍼레이티드 글리코겐 신타제 키나제 3 (gsk3) 억제제로서의 트리시클릭 화합물 및 그의 용도
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
TWI796329B (zh) 2017-04-07 2023-03-21 美商默沙東有限責任公司 抗－ilt4抗體及抗原結合片段
KR20190140454A (ko) 2017-04-13 2019-12-19 아두로 바이오테크 홀딩스, 유럽 비.브이. 항-sirp 알파 항체
US11358926B2 (en) 2017-04-25 2022-06-14 Amicus Therapeutics, Inc. Compositions for preventing and/or treating degenerative disorders of the central nervous system and/or lysosomal storage disorders
UY37726A (es) 2017-05-05 2018-11-30 Amgen Inc Composición farmacéutica que comprende constructos de anticuerpos biespecíficos para almacenamiento y administración mejorados
WO2018207023A2 (en) 2017-05-10 2018-11-15 Albajuna Therapeutics, S.L. Fc-fusion protein derivatives with high dual hiv antiviral and immunomodulatory activity
US11168129B2 (en) 2017-05-15 2021-11-09 University Of Rochester Broadly neutralizing anti-influenza human monoclonal antibody and uses thereof
KR20200013241A (ko) 2017-05-25 2020-02-06 브리스톨-마이어스 스큅 컴퍼니 변형된 중쇄 불변 영역을 포함하는 항체
WO2018232120A1 (en) 2017-06-14 2018-12-20 Modernatx, Inc. Compounds and compositions for intracellular delivery of agents
KR20200020858A (ko) 2017-06-23 2020-02-26 브리스톨-마이어스 스큅 컴퍼니 Pd-1의 길항제로서 작용하는 면역조정제
EP3641828B1 (de) 2017-06-23 2023-11-22 Affinivax, Inc. Immunogene zusammensetzungen
US20210147571A1 (en) 2017-06-23 2021-05-20 Suzhou Bojuhua Biomedical Technology Co. Ltd Monoclonal antibody targeting human tumor stem cells and use thereof
WO2019013789A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS
WO2019013790A1 (en) 2017-07-12 2019-01-17 Curza Global, Llc ANTIMICROBIAL COMPOUNDS AND USES THEREOF
MA49948A (fr) 2017-08-22 2020-07-01 Biogen Ma Inc Compositions pharmaceutiques et schémas posologiques contenant des anticorps anti-alpha (v) bêta (6)
US11414450B1 (en) 2017-08-28 2022-08-16 Revagenix, Inc. Aminoglycosides and uses thereof
JP2020531041A (ja) 2017-08-28 2020-11-05 上海易楽生物技術有限公司 ポリペプチドとポリペプチドに結合される抗体
EP3675817A1 (de) 2017-08-31 2020-07-08 Modernatx, Inc. Verfahren zur herstellung von lipidnanopartikeln
JP7257393B2 (ja) 2017-10-03 2023-04-13 ブリストル－マイヤーズ スクイブ カンパニー 免疫調節剤
JP2020537506A (ja) 2017-10-04 2020-12-24 アムジエン・インコーポレーテツド トランスサイレチン免疫グロブリン融合物
WO2019075090A1 (en) 2017-10-10 2019-04-18 Tilos Therapeutics, Inc. ANTI-LAP ANTIBODIES AND USES THEREOF
CN111465701A (zh) 2017-10-11 2020-07-28 绿光生物科技股份有限公司 用于三磷酸核苷和核糖核酸生成的方法和组合物
EP3700938A1 (de) 2017-10-26 2020-09-02 ImmuneOnco Biopharmaceuticals (Shanghai) Co., Ltd. Neuartige rekombinante fusionsproteine, herstellung und verwendung davon
JP2021501801A (ja) 2017-11-01 2021-01-21 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 癌の処置に用いるための免疫刺激アゴニスト抗体
SG11202004426SA (en) 2017-11-17 2020-06-29 Merck Sharp & Dohme Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof
WO2019109079A1 (en) 2017-12-01 2019-06-06 North Carolina State University Fibrin particles and methods of making the same
EP3724229A1 (de) 2017-12-11 2020-10-21 Amgen Inc. Kontinuierliches herstellungsverfahren für bispezifische antikörperprodukte
GB201721582D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa S aureus antigens and immunogenic compositions
JP2021507945A (ja) 2017-12-21 2021-02-25 グリアファーム エスエー 認知症を含む神経障害のための組成物および治療方法
GB201721576D0 (en) 2017-12-21 2018-02-07 Glaxosmithkline Biologicals Sa Hla antigens and glycoconjugates thereof
AU2018392985A1 (en) 2017-12-21 2020-06-04 Gliapharm Sa Compositions and methods of treatment for neurological disorders comprising motor neuron diseases
TW201932107A (zh) * 2017-12-21 2019-08-16 台灣微脂體股份有限公司 緩釋型翠普登組成物及其經皮下或類似途徑使用之方法
WO2019133747A1 (en) 2017-12-27 2019-07-04 Bristol-Myers Squibb Company Anti-cd40 antibodies and uses thereof
UY38041A (es) 2017-12-29 2019-06-28 Amgen Inc Construcción de anticuerpo biespecífico dirigida a muc17 y cd3
KR20200108870A (ko) 2018-01-12 2020-09-21 브리스톨-마이어스 스큅 컴퍼니 Tim3에 대한 항체 및 그의 용도
WO2019148412A1 (en) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies
CN111868082A (zh) 2018-02-02 2020-10-30 博奥泰克尼公司 调节vista和vsig3的相互作用的化合物及其制备和使用方法
KR101859735B1 (ko) * 2018-02-07 2018-05-21 주식회사 피테크 무통 주사 장치
EP3749363A1 (de) 2018-02-08 2020-12-16 Amgen Inc. Pharmazeutische antikörperformulierung mit niedrigem ph-wert
NL2020520B1 (en) 2018-03-02 2019-09-12 Labo Bio Medical Invest B V Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders
AU2019235424B2 (en) 2018-03-15 2023-12-21 BioNTech SE 5'-cap-trinucleotide- or higher oligonucleotide compounds and their uses in stabilizing RNA, expressing proteins and in therapy
CN111886256A (zh) 2018-03-23 2020-11-03 百时美施贵宝公司 抗mica和/或micb抗体及其用途
WO2019184920A1 (zh) 2018-03-26 2019-10-03 上海易乐生物技术有限公司 proBDNF调节剂在B细胞相关疾病中的用途
TWI790370B (zh) 2018-04-02 2023-01-21 美商必治妥美雅史谷比公司 抗trem-1抗體及其用途
WO2019194858A1 (en) 2018-04-03 2019-10-10 Achaogen, Inc. Modular synthesis of aminoglycosides
CA3096055A1 (en) 2018-04-06 2019-10-10 Rhythm Pharmaceuticals, Inc. Compositions for treating kidney disease
CA3096674A1 (en) 2018-04-12 2019-10-17 Bristol-Myers Squibb Company Anticancer combination therapy with cd73 antagonist antibody and pd-1/pd-l1 axis antagonist antibody
AU2019256383A1 (en) 2018-04-17 2020-11-26 Celldex Therapeutics, Inc. Anti-CD27 and anti-PD-L1 antibodies and bispecific constructs
EP3781206A2 (de) 2018-04-20 2021-02-24 iOmx Therapeutics AG 5-thiazolcarboxamid-kinase-hemmer und verwendungen davon
KR102107578B1 (ko) * 2018-05-02 2020-05-07 주식회사 피테크 무통 주사기용 약액주입 제어장치 및 이를 구비하는 무통 주사기
KR102104080B1 (ko) * 2018-05-02 2020-04-23 주식회사 피테크 무통 주사기용 음파발진장치 및 이를 구비하는 무통 주사기
KR101907552B1 (ko) * 2018-05-03 2018-10-12 주식회사 피테크 무바늘 무통 주사 장치
WO2019213384A1 (en) 2018-05-03 2019-11-07 University Of Rochester Anti-influenza neuraminidase monoclonal antibodies and uses thereof
WO2019226977A1 (en) 2018-05-25 2019-11-28 Primmune Therapeutics, Inc. Tlr7 agonists
WO2019236417A1 (en) 2018-06-04 2019-12-12 Biogen Ma Inc. Anti-vla-4 antibodies having reduced effector function
US11951286B2 (en) * 2018-06-12 2024-04-09 Banza Stamping Industry Corp. Automatic injection device for fluid
GB201809746D0 (en) 2018-06-14 2018-08-01 Berlin Chemie Ag Pharmaceutical combinations
SG11202012706PA (en) 2018-06-21 2021-01-28 Yumanity Therapeutics Inc Compositions and methods for the treatment and prevention of neurological disorders
BR112020026672A2 (pt) 2018-06-27 2021-03-30 Bioxcel Therapeutics, Inc. Formulações de filme contendo dexmedetomidina e métodos para produzi-las
SG11202013167UA (en) 2018-07-11 2021-01-28 Kahr Medical Ltd SIRPalpha-4-1BBL VARIANT FUSION PROTEIN AND METHODS OF USE THEREOF
US11929160B2 (en) 2018-07-16 2024-03-12 Kaleo, Inc. Medicament delivery devices with wireless connectivity and compliance detection
WO2020025532A1 (en) 2018-07-30 2020-02-06 Amgen Research (Munich) Gmbh Prolonged administration of a bispecific antibody construct binding to cd33 and cd3
EA202190382A1 (ru) 2018-07-31 2021-05-17 Эмджен Инк. Фармацевтические составы на основе маскированных антител
AU2019316164A1 (en) 2018-07-31 2021-01-21 Amgen Inc. Dosing regimen for BCMA-CD3 bispecific antibodies
CA3107192A1 (en) 2018-08-03 2020-02-06 Amgen Research (Munich) Gmbh Antibody constructs for cldn18.2 and cd3
EP3833690B1 (de) 2018-08-08 2024-03-27 ImmuneOnco Biopharmaceuticals (Shanghai) Inc. Gegen cd47 und her2 gerichtetes, rekombinantes bifunktionales protein
WO2020049208A1 (es) 2018-09-09 2020-03-12 Fundacio Privada Institut De Recerca De La Sida - Caixa Aurora cinasa como diana para tratar, prevenir o curar una infección por vih o sida
KR20210089143A (ko) 2018-09-18 2021-07-15 메리맥 파마슈티컬즈, 인크. 항-tnfr2 항체 및 그의 용도
US20220409536A1 (en) 2018-09-19 2022-12-29 Modernatx, Inc. Compounds and compositions for intracellular delivery of therapeutic agents
CA3113651A1 (en) 2018-09-20 2020-03-26 Modernatx, Inc. Preparation of lipid nanoparticles and methods of administration thereof
KR102199724B1 (ko) * 2018-10-05 2021-01-07 주식회사 피테크 무바늘 무통 주사 장치
US11130802B2 (en) 2018-10-10 2021-09-28 Tilos Therapeutics, Inc. Anti-lap antibody variants
CA3114802A1 (en) 2018-10-11 2020-04-16 Amgen Inc. Downstream processing of bispecific antibody constructs
EP3643713A1 (de) 2018-10-23 2020-04-29 iOmx Therapeutics AG Heterocyclische kinasehemmer und verwendungen davon
WO2020084005A1 (en) 2018-10-23 2020-04-30 Myelopro Diagnostics And Research Gmbh Compounds targeting mutant calreticulin
US11160791B2 (en) 2018-11-01 2021-11-02 Medefil, Inc. Dexmedetomidine injection premix formulation in ready to use (RTU) bags
EP4257195A3 (de) 2018-11-09 2024-01-03 University of Massachusetts Anti-cfae-antikörper und verfahren zur verwendung
TW202033555A (zh) 2018-11-16 2020-09-16 美商必治妥美雅史谷比公司 抗nkg2a抗體及其用途
EP3887397A1 (de) 2018-11-28 2021-10-06 Bristol-Myers Squibb Company Antikörper mit modifizierten schweren konstanten regionen
WO2020118011A1 (en) 2018-12-06 2020-06-11 Alexion Pharmaceuticals, Inc. Anti-alk2 antibodies and uses thereof
EP3898672A1 (de) 2018-12-18 2021-10-27 Regeneron Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur erhöhung des körpergewichts und der magermuskelmasse unter verwendung von antagonisten gegen leptinrezeptor, gdf8 und activin a
TW202039554A (zh) 2018-12-19 2020-11-01 瑞士商諾華公司 抗ＴＮＦ－α抗體
WO2020132378A2 (en) 2018-12-22 2020-06-25 Gliapharm Sa Compositions and methods of treatment for neurological disorders comprising depression
WO2020144535A1 (en) 2019-01-08 2020-07-16 Aduro Biotech Holdings, Europe B.V. Methods and compositions for treatment of multiple myeloma
US20230072397A1 (en) 2019-01-16 2023-03-09 Curza Global, Llc Antimicrobial Compounds and Methods
US20230159491A1 (en) 2019-01-16 2023-05-25 Curza Global, Llc Antimicrobial Compounds and Methods
CN109762067B (zh) 2019-01-17 2020-02-28 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
PE20212305A1 (es) 2019-01-22 2021-12-10 Bristol Myers Squibb Co Anticuerpos contra subunidad alfa il-7r y usos de estos
WO2020154447A1 (en) 2019-01-22 2020-07-30 Aeovian Pharmaceuticals, Inc. Mtorc modulators and uses thereof
CN113329763A (zh) 2019-01-22 2021-08-31 豪夫迈·罗氏有限公司 免疫球蛋白a抗体以及制备和使用方法
JP2022519557A (ja) 2019-01-31 2022-03-24 モデルナティエックス インコーポレイテッド 脂質ナノ粒子の調製方法
WO2020168466A1 (en) 2019-02-19 2020-08-27 Stemirna Therapeutics Co., Ltd. Modified nucleoside and synthetic methods thereof
EP3930846A1 (de) 2019-03-01 2022-01-05 Merrimack Pharmaceuticals, Inc. Anti-tnfr2-antikörper und verwendungen davon
CN113661179A (zh) 2019-03-11 2021-11-16 比奥根Ma公司 含有抗lingo-1抗体的药物组合物
US11230593B2 (en) 2019-03-25 2022-01-25 Visterra, Inc. Compositions and methods for treating and preventing influenza
CA3136488A1 (en) 2019-04-08 2020-10-15 Biogen Ma Inc. Anti-integrin antibodies and uses thereof
KR20220010535A (ko) 2019-05-21 2022-01-25 브리스톨-마이어스 스큅 컴퍼니 면역조정제
SG11202112462RA (en) 2019-06-11 2021-12-30 Regeneron Pharma Anti-pcrv antibodies that bind pcrv, compositions comprising anti-pcrv antibodies, and methods of use thereof
TW202045711A (zh) 2019-06-13 2020-12-16 美商安進公司 生物製品製造中基於生物量之自動灌注控制
WO2021007150A1 (en) 2019-07-08 2021-01-14 Amgen Inc. Multispecific transthyretin immunoglobulin fusions
JP2022541742A (ja) 2019-07-11 2022-09-27 カール メディカル リミテッド ヘテロダイマーおよびその使用方法
WO2021011678A1 (en) 2019-07-15 2021-01-21 Bristol-Myers Squibb Company Anti-trem-1 antibodies and uses thereof
WO2021011681A1 (en) 2019-07-15 2021-01-21 Bristol-Myers Squibb Company Antibodies against human trem-1 and uses thereof
CN114174336A (zh) 2019-07-15 2022-03-11 英特维特国际股份有限公司 针对人和犬ctla-4的犬源化抗体
WO2021009187A1 (en) 2019-07-15 2021-01-21 Intervet International B.V. Caninized antibodies against canine ctla-4
KR20220049526A (ko) 2019-07-19 2022-04-21 바이오엑셀 테라퓨틱스 인코포레이티드 비-진정성 덱스메데토미딘 치료 양생법
US20220265803A1 (en) 2019-07-31 2022-08-25 Sanofi Pasteur Inc. Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of using the same
AU2020319876A1 (en) 2019-07-31 2022-02-24 Modernatx, Inc. Compositions and methods for delivery of RNA interference agents to immune cells
WO2021030210A1 (en) * 2019-08-09 2021-02-18 Kaleo, Inc. Devices and methods for delivery of substances within a prefilled syringe
US20220289807A1 (en) 2019-08-13 2022-09-15 Amgen Inc. Interleukin-2 muteins for the expansion of t-regulatory cells
US20220340643A1 (en) 2019-09-13 2022-10-27 Rutgers, The State University Of New Jersey Aav-compatible laminin-linker polymerization proteins
WO2021087056A1 (en) 2019-10-30 2021-05-06 Bristol-Myers Squibb Company Immunomodulators
EP3819007A1 (de) 2019-11-11 2021-05-12 Amgen Research (Munich) GmbH Dosierschema für anti-bcma-wirkstoffe
WO2021097061A1 (en) 2019-11-13 2021-05-20 Curza Global, Llc Antimicrobial compounds and methods
AU2020381536A1 (en) 2019-11-13 2022-04-21 Amgen Inc. Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules
EP4061818B1 (de) 2019-11-19 2023-12-06 Bristol-Myers Squibb Company Makrozyklische peptide als pd-l1 inhibitoren und immunomodulatoren zur behandlung von krebs und infektionserkrankungen
CN115551885A (zh) 2019-12-11 2022-12-30 威特拉公司 用于治疗和预防流感的组合物和方法
IL293471A (en) 2019-12-17 2022-08-01 Amgen Inc Dual interleukin-2 / tnf receptor agonist for use in medicine
MX2022007677A (es) 2019-12-20 2022-07-19 Intervet Int Bv Anticuerpos para receptor alfa de interleucina-4 canino.
BR112022011669A2 (pt) 2019-12-20 2022-09-06 Intervet Int Bv Anticorpos biespecíficos caninizados e parceiros de ligação biespecíficos para tratar dermatite atópica
MX2022007688A (es) 2019-12-20 2022-07-19 Amgen Inc Constructos de anticuerpo multiespecificos agonistas de cd40 dirigidos a mesotelina para el tratamiento de tumores solidos.
CN114929728A (zh) 2020-01-06 2022-08-19 百时美施贵宝公司 免疫调节剂
KR20220122751A (ko) 2020-01-06 2022-09-02 브리스톨-마이어스 스큅 컴퍼니 암 및 감염성 질환의 치료를 위한 pd-l1 억제제 및 면역조정제로서의 마크로시클릭 펩티드
CN110818795B (zh) 2020-01-10 2020-04-24 上海复宏汉霖生物技术股份有限公司 抗tigit抗体和使用方法
US20230093169A1 (en) 2020-01-22 2023-03-23 Amgen Research (Munch) Gmbh Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof
WO2021155274A1 (en) 2020-01-31 2021-08-05 Modernatx, Inc. Methods of preparing lipid nanoparticles
CN115087673A (zh) 2020-02-27 2022-09-20 正大天晴药业集团股份有限公司 结合il4r的抗体及其用途
WO2021173965A1 (en) 2020-02-28 2021-09-02 Massachusetts Institute Of Technology Identification of variable influenza residues and uses thereof
KR20220151189A (ko) 2020-03-09 2022-11-14 브리스톨-마이어스 스큅 컴퍼니 증진된 효능제 활성을 갖는 cd40에 대한 항체
US20230183292A1 (en) 2020-03-16 2023-06-15 Bristol-Myers Squibb Company Immunomodulators
WO2021188851A1 (en) 2020-03-19 2021-09-23 Amgen Inc. Antibodies against mucin 17 and uses thereof
WO2021195089A1 (en) 2020-03-23 2021-09-30 Sorrento Therapeutics, Inc. Fc-coronavirus antigen fusion proteins, and nucleic acids, vectors, compositions and methods of use thereof
KR20220161407A (ko) 2020-03-30 2022-12-06 브리스톨-마이어스 스큅 컴퍼니 면역조정제
WO2021202235A1 (en) 2020-04-01 2021-10-07 University Of Rochester Monoclonal antibodies against the hemagglutinin (ha) and neuraminidase (na) of influenza h3n2 viruses
EP4132971A1 (de) 2020-04-09 2023-02-15 Merck Sharp & Dohme LLC Affinitätsgereifte anti-lap-antikörper und verwendungen davon
WO2021216488A1 (en) 2020-04-21 2021-10-28 Regeneron Pharmaceuticals, Inc. Il-2 variants with reduced binding to il-2 receptor alpha and uses thereof
EP3901151A1 (de) 2020-04-21 2021-10-27 iOmx Therapeutics AG Halogenierte heteroaryl- und andere heterocyclische kinaseinhibitoren und verwendungen davon
WO2021219731A2 (en) 2020-04-28 2021-11-04 Iomx Therapeutics Ag Bicyclic kinase inhibitors and uses thereof
WO2021222935A2 (en) 2020-04-28 2021-11-04 The Rockefeller University Neutralizing anti-sars-cov-2 antibodies and methods of use thereof
WO2021222347A1 (en) 2020-04-29 2021-11-04 Amgen Inc. Pharmaceutical formulation
CN115484980A (zh) 2020-04-29 2022-12-16 安进公司 药物配制品
EP4143227A2 (de) 2020-04-30 2023-03-08 Sairopa B.V. Anti-cd103 antikörper
KR20230008790A (ko) 2020-05-08 2023-01-16 브리스톨-마이어스 스큅 컴퍼니 면역조정제
WO2021231729A1 (en) 2020-05-13 2021-11-18 Sanofi Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
AU2021275049A1 (en) 2020-05-19 2022-12-22 Amgen Inc. MAGEB2 binding constructs
US20230277524A1 (en) 2020-05-22 2023-09-07 Trailhead Biosystems Inc. Combination therapy for treatment of viral infections
JP2023527972A (ja) 2020-05-29 2023-07-03 アムジエン・インコーポレーテツド Ｃｄ３３及びｃｄ３に結合する二重特異性コンストラクトの有害作用軽減投与
WO2021252708A1 (en) 2020-06-11 2021-12-16 President And Fellows Of Harvard College Stabilized trioxacarcin antibody drug conjugates and uses thereof
FR3112939B1 (fr) 2020-07-31 2024-01-05 Univ Montpellier Produit universel de thérapie cellulaire et son utilisation
CN116419747A (zh) 2020-08-07 2023-07-11 福蒂斯治疗公司 靶向cd46的免疫偶联物及其使用方法
WO2022046651A1 (en) 2020-08-24 2022-03-03 Amgen Inc. Pharmaceutical formulation comprising a bite, bispecific antibody, and methionine
CN116322735A (zh) 2020-10-02 2023-06-23 百时美施贵宝公司 大环肽硼酸盐免疫调节剂
CN116323639A (zh) 2020-10-08 2023-06-23 百时美施贵宝公司 二聚体milla免疫调节剂
US20230365628A1 (en) 2020-10-09 2023-11-16 Bristol-Myers Squibb Company Macrocyclic immunomodulators
WO2022079139A1 (en) 2020-10-15 2022-04-21 Intervet International B.V. Caninized antibodies to canine interleukin-31 receptor alpha
CN116710116A (zh) 2020-10-30 2023-09-05 Ｘｅｎｏ－Ｉｎｔｅｒｆａｃｅ株式会社 β折叠股桥肽
CN117083065A (zh) 2020-10-30 2023-11-17 庆应义塾 肌肉减少症相关疾病等的新颖治疗和预防
US11919945B2 (en) 2020-11-04 2024-03-05 The Rockefeller University Neutralizing anti-SARS-CoV-2 antibodies
BR112023008629A2 (pt) 2020-11-06 2023-10-03 Amgen Inc Construtos de polipeptídeos que se ligam seletivamente a cldn6 e cd3
KR20230098335A (ko) 2020-11-06 2023-07-03 암젠 인크 클리핑 비율이 감소된 항원 결합 도메인
CN116635421A (zh) 2020-11-06 2023-08-22 安进公司 与cd3结合的多肽构建体
UY39508A (es) 2020-11-06 2022-05-31 Amgen Res Munich Gmbh Moléculas de unión a antígeno biespecíficas con múltiples dianas de selectividad aumentada
WO2022103781A1 (en) 2020-11-10 2022-05-19 Amgen Inc. Methods for administering a bcma x cd3 binding molecule
AU2021380005A1 (en) 2020-11-11 2023-06-01 BioNTech SE Monoclonal antibodies directed against programmed death-1 protein and their use in medicine
TW202237068A (zh) 2020-12-09 2022-10-01 美商建南德克公司 製備脂質奈米顆粒的高通量方法及其用途
CN114685669A (zh) 2020-12-30 2022-07-01 和铂医药(苏州)有限公司 结合trop2的抗体及其用途
JP2024505636A (ja) 2021-01-15 2024-02-07 ザ ロックフェラー ユニバーシティー 抗ｓａｒｓ－ｃｏｖ－２中和抗体
EP4305088A1 (de) 2021-03-09 2024-01-17 Massachusetts Institute of Technology Verzweigte poly(aminoester) zur verabreichung von nukleinsäuren
WO2022192790A1 (en) 2021-03-12 2022-09-15 Bristol-Myers Squibb Company Kras inhibitors
WO2022204412A1 (en) 2021-03-24 2022-09-29 Bristol-Myers Squibb Company Immunomodulators
KR20240006541A (ko) 2021-04-09 2024-01-15 셀덱스 쎄라퓨틱스, 인크. Ilt4에 대한 항체, 이중특이적 항-ilt4/pd-l1 항체 및 이의 용도
EP4323380A2 (de) 2021-04-12 2024-02-21 Bristol-Myers Squibb Company Zyklische peptidimmunmodulatoren
WO2022235867A2 (en) 2021-05-06 2022-11-10 The Rockefeller University Neutralizing anti-sars- cov-2 antibodies and methods of use thereof
EP4333805A1 (de) 2021-05-06 2024-03-13 Amgen Inc. Etelcalcetidformulierungen
CN117279947A (zh) 2021-05-06 2023-12-22 安进研发（慕尼黑）股份有限公司 用于在增殖性疾病中使用的靶向cd20和cd22的抗原结合分子
KR20240017813A (ko) 2021-05-10 2024-02-08 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. 신경질환 치료용 약학적 조성물
EP4346882A1 (de) 2021-05-26 2024-04-10 Oxford BioTherapeutics Ltd Pharmazeutische kombination mit einem anti-cd205-antikörper und einem immun-checkpoint-inhibitor
TW202313065A (zh) 2021-05-28 2023-04-01 美商季卡尼醫療公司 用於治療遺傳疾病之化合物
WO2022258792A1 (en) 2021-06-09 2022-12-15 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Novel anti-fibrotic drugs
CN117425666A (zh) 2021-06-09 2024-01-19 百时美施贵宝公司 环肽免疫调节剂
CN117377695A (zh) 2021-06-30 2024-01-09 安进公司 冻干制剂的重构方法
WO2023288213A1 (en) 2021-07-12 2023-01-19 Bristol-Myers Squibb Company Macrocyclic immunomodulators
KR20240035843A (ko) 2021-07-19 2024-03-18 브리스톨-마이어스 스큅 컴퍼니 마크로시클릭 면역조정제
CN117693355A (zh) 2021-07-20 2024-03-12 瑞泽恩制药公司 用于治疗炎性病症的嗜乳脂蛋白样2
CN113398365B (zh) * 2021-07-21 2022-10-28 南京瑞淇卓越医疗美容诊所有限公司 一种心血管内科用的临床造影注射装置及注射方法
WO2023018817A1 (en) 2021-08-11 2023-02-16 Sanofi Pasteur Inc. Truncated influenza neuraminidase and methods of using the same
CA3227816A1 (en) 2021-08-20 2023-02-23 Intervet International B.V. Fusion proteins for treating atopic dermatitis
CA3227716A1 (en) 2021-08-20 2023-02-23 Intervet International B.V. Antibodies and igg fusion proteins with an extended half-life
US20230233667A1 (en) 2021-09-08 2023-07-27 Affinivax, Inc. Coronavirus vaccine
CN113773401B (zh) 2021-09-15 2023-06-20 宜明昂科生物医药技术（上海）股份有限公司 靶向cd47和pd-l1的重组融合蛋白及其制备和用途
WO2023059857A1 (en) 2021-10-08 2023-04-13 Sanofi Pasteur Inc. Multivalent influenza vaccines
CN113754769B (zh) 2021-10-13 2023-06-06 宜明昂科生物医药技术（上海）股份有限公司 靶向cd70的抗体及其制备和用途
CN113956363B (zh) 2021-10-13 2023-03-31 宜明昂科生物医药技术（上海）股份有限公司 靶向cd47和cd24的重组融合蛋白及其制备和用途
CN113831412B (zh) 2021-10-13 2023-06-20 宜明昂科生物医药技术（上海）股份有限公司 靶向cd24的抗体及其制备和用途
WO2023069994A1 (en) 2021-10-20 2023-04-27 Bristol-Myers Squibb Company Immunomodulators
CA3233696A1 (en) 2021-11-03 2023-05-11 Joachim Koch Bispecific cd16a binders
WO2023079493A1 (en) 2021-11-03 2023-05-11 Affimed Gmbh Bispecific cd16a binders
WO2023081798A1 (en) 2021-11-05 2023-05-11 Sanofi Pasteur Inc. Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same
WO2023079113A1 (en) 2021-11-05 2023-05-11 Sanofi Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same
WO2023077521A1 (en) 2021-11-08 2023-05-11 Celldex Therapeutics, Inc Anti-ilt4 and anti-pd-1 bispecific constructs
WO2023089314A1 (en) 2021-11-18 2023-05-25 Oxford Biotherapeutics Limited Pharmaceutical combinations
WO2023096904A2 (en) 2021-11-24 2023-06-01 President And Fellows Of Harvard College C-16 modified trioxacarcins, antibody drug conjugates, and uses thereof
WO2023102507A1 (en) 2021-12-03 2023-06-08 Bristol-Myers Squibb Company Macrocyclic immunomodulators
WO2023105281A1 (en) 2021-12-11 2023-06-15 Fundaciò Privada Institut De Recerca De La Sida-Caixa Soluble tigit recombinant proteins
WO2023114884A2 (en) 2021-12-15 2023-06-22 Interius Biotherapeutics, Inc. Pseudotyped viral particles, compositions comprising the same, and uses thereof
WO2023114889A1 (en) 2021-12-16 2023-06-22 Modernatx, Inc. Processes for preparing lipid nanoparticles
WO2023111153A1 (en) 2021-12-16 2023-06-22 Intervet International B.V. Caninized antibodies to human ngf
WO2023111128A1 (en) 2021-12-16 2023-06-22 Intervet International B.V. Caninized antibodies to canine interleukin-31 receptor alpha ii
WO2023129963A1 (en) 2021-12-30 2023-07-06 Curza Global, Llc Antimicrobial compounds and methods
WO2023144206A1 (en) 2022-01-27 2023-08-03 Sanofi Pasteur Modified vero cells and methods of using the same for virus production
WO2023147399A1 (en) 2022-01-27 2023-08-03 The Rockefeller University Broadly neutralizing anti-sars-cov-2 antibodies targeting the n-terminal domain of the spike protein and methods of use thereof
WO2023166488A1 (en) 2022-03-04 2023-09-07 Revagenix, Inc. Broad spectrum aminoglycosides and uses thereof
WO2023177577A1 (en) 2022-03-14 2023-09-21 Sanofi Pasteur Inc. Machine-learning techniques in protein design for vaccine generation
WO2023175171A1 (en) 2022-03-18 2023-09-21 Inserm (Institut National De La Sante Et De La Recherche Medicale) Bk polyomavirus antibodies and uses thereof
WO2023192873A1 (en) 2022-03-28 2023-10-05 Bristol-Myers Squibb Company Macrocyclic immunomodulators
WO2023193002A1 (en) 2022-04-01 2023-10-05 Modernatx, Inc. Cross mixers for lipid nanoparticle production, and methods of operating the same
EP4257609A1 (de) 2022-04-08 2023-10-11 iOmx Therapeutics AG Kombinationstherapien basierend auf pd-1-inhibitoren und sik3-inhibitoren
EP4257132A1 (de) 2022-04-08 2023-10-11 iOmx Therapeutics AG Sik3-inhibitoren zum behandeln von krankheiten, die gegen death-rezeptor -signaltransduktion resistent sind
WO2023212559A1 (en) 2022-04-26 2023-11-02 Amgen Inc. Lyophilization method
WO2023217987A1 (en) 2022-05-12 2023-11-16 BioNTech SE Monoclonal antibodies directed against programmed death-1 protein and their use in medicine
TW202346368A (zh) 2022-05-12 2023-12-01 德商安美基研究（慕尼黑）公司 具有增加的選擇性的多鏈多靶向性雙特異性抗原結合分子
GB202207263D0 (en) 2022-05-18 2022-06-29 Annexin Pharmaceuticals Ab Therapeutic compositions
WO2023225661A1 (en) 2022-05-20 2023-11-23 Bristol-Myers Squibb Company Macrocyclic immunomodulators
WO2023235380A1 (en) 2022-06-01 2023-12-07 Zikani Therapeutics, Inc. Macrolides for treating genetic diseases
US20240067662A1 (en) 2022-06-10 2024-02-29 Bristol-Myers Squibb Company Kras inhibitors
WO2023240189A1 (en) 2022-06-10 2023-12-14 Bristol-Myers Squibb Company Tetrahydropyrido 3,4-d pyrimidine derivatives as kras inhibitors
WO2023250513A1 (en) 2022-06-24 2023-12-28 Zikani Therapeutics, Inc. 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation
WO2024026482A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising surface lipid derivatives and related uses
WO2024026487A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Lipid nanoparticle compositions comprising phospholipid derivatives and related uses
WO2024026475A1 (en) 2022-07-29 2024-02-01 Modernatx, Inc. Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses
WO2024036270A1 (en) 2022-08-11 2024-02-15 Bristol-Myers Squibb Company Kras inhibitors
WO2024040109A2 (en) 2022-08-16 2024-02-22 Bristol-Myers Squibb Company Kras inhibitors
WO2024049994A1 (en) 2022-09-01 2024-03-07 Zikani Therapeutics, Inc. Treatment of familial adenomatous polyopsis using a 13-membered macrolide
WO2024054926A1 (en) 2022-09-07 2024-03-14 Bristol-Myers Squibb Company Kras g12d inhibitors
WO2024059472A1 (en) 2022-09-12 2024-03-21 Bristol-Myers Squibb Company Macrocyclic immunomodulators
WO2024059675A2 (en) 2022-09-14 2024-03-21 Amgen Inc. Bispecific molecule stabilizing composition

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2704543A (en) * 1955-03-22 Hypo jet injector
US2101140A (en) * 1935-03-23 1937-12-07 Raymond W Hege Automatic injecting syringe device
US2380534A (en) * 1941-04-26 1945-07-31 Marshall L Lockhart Hypodermic injector
US2605763A (en) * 1948-01-31 1952-08-05 Becton Dickinson Co Injection device
US2547099A (en) * 1948-03-11 1951-04-03 Becton Dickinson Co Injection device and ampoule
US2680439A (en) * 1948-09-08 1954-06-08 Arnold K Sutermeister High-pressure injection device
US2670121A (en) * 1951-01-31 1954-02-23 Scherer Corp R P Flexible follower for metal ampoules
US2816543A (en) * 1954-07-12 1957-12-17 Scherer Corp R P Hypodermic injector
NL133848C (de) * 1960-08-15
US3292621A (en) * 1963-07-19 1966-12-20 Oscar H Banker Jet type protable inoculator
US3292622A (en) * 1964-09-21 1966-12-20 Oscar H Banker Power operated inoculator
US3424154A (en) * 1965-11-08 1969-01-28 Charles W Kinsley Injection system
US3561443A (en) * 1968-09-06 1971-02-09 Oscar H Banker Inoculator gun with delayed action
US3688765A (en) * 1969-10-03 1972-09-05 Jack S Gasaway Hypodermic injection device
US3945379A (en) * 1974-08-08 1976-03-23 Smithkline Corporation Injection device
JPS51130094A (en) * 1975-05-08 1976-11-12 Asahi Chemical Ind Twoostage pressure injector
CA1178503A (en) * 1982-05-27 1984-11-27 Health-Mor Personal Care Corporation Needleless hypodermic injector
HU186718B (en) * 1983-06-29 1985-09-30 Radelkis Electrokemiai Automatic needleless syringe operable by cardox cylinder suitable for personal giving injection e.g. insulin
US4596556A (en) * 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4680027A (en) * 1985-12-12 1987-07-14 Injet Medical Products, Inc. Needleless hypodermic injection device
EP0250022A3 (de) * 1986-06-17 1988-06-22 SICIM SpA Tragbarer hypodermatischer Injektor
US4722728A (en) * 1987-01-23 1988-02-02 Patents Unlimited, Ltd. Needleless hypodermic injector
US4790824A (en) * 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4940460A (en) * 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US4941880A (en) * 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
DE3814023A1 (de) * 1987-07-13 1989-01-26 Medizin Labortechnik Veb K Injektionsvorrichtung mit medikamentendepot
AU628029B2 (en) * 1987-11-16 1992-09-10 Sy-Quest International Limited Improved apparatus for hypodermic injection of liquids
US5073165A (en) * 1988-02-05 1991-12-17 Marpam International, Inc. Hypodermic jet injector and cartridge therefor
US4913699A (en) * 1988-03-14 1990-04-03 Parsons James S Disposable needleless injection system
US5024656A (en) * 1988-08-30 1991-06-18 Injet Medical Products, Inc. Gas-pressure-regulated needleless injection system
CA1325149C (en) * 1989-08-31 1993-12-14 Gavin Mcgregor Variable intensity remote controlled needleless injector
US5064413A (en) * 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5062830A (en) * 1990-04-04 1991-11-05 Derata Corporation Dry disposable nozzle assembly for medical jet injector
US5383851A (en) * 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102020134181A1 (de) 2020-12-18 2022-06-23 Henke-Sass, Wolf Gmbh Vorrichtung zum Applizieren eines Fluids

Also Published As

Publication number Publication date
JP2004141667A (ja) 2004-05-20
US5383851A (en) 1995-01-24
JPH07509161A (ja) 1995-10-12
CA2140772A1 (en) 1994-02-03
EP0651663B1 (de) 1999-12-01
US5399163A (en) 1995-03-21
DE69327165D1 (de) 2000-01-05
EP0651663A1 (de) 1995-05-10
CA2140772C (en) 2006-07-11
ATE187083T1 (de) 1999-12-15
AU676490B2 (en) 1997-03-13
EP0651663A4 (de) 1995-08-30
JP3633615B2 (ja) 2005-03-30
WO1994002188A1 (en) 1994-02-03
AU4782793A (en) 1994-02-14
US5520639A (en) 1996-05-28

Similar Documents

Publication Publication Date Title
DE69327165T2 (de) Verfahren für nadellose subkutaninjektionen
US4421508A (en) Vacuum-compression injector
US6939319B1 (en) Process and device for single use, needle-free intradermal, subcutaneous, or intramuscular injections
US4403609A (en) Vacuum-compression injector
US5370630A (en) Device for injection of fluidic materials into body tissue
WO1993003780A1 (en) Injection syringe
EP0879609A3 (de) Zweistufiger Druckstrahlinjektor
DE60336940D1 (de) Medizinisches Injektionsgerät
GB9100819D0 (en) Subcutaneous injector
CA2148173A1 (en) Delivery Device for Injectable Materials
AU5488296A (en) Self-purging angiographic injector
US20070191762A1 (en) Needleless injector and ampule system
EP0375584A3 (de) Injektionsvorrichtung für medizinischen und tierärztlichen Gebrauch, die Infektionen verhindert
WO1994002188A9 (en) Needleless hypodermic injection methods and device
MX9801372A (es) Impulsor de jeringa de multiples dosis.
ATE478604T1 (de) Angiographische injektoranordnung
AU2003209095A1 (en) Intradermal injector
ATE303832T1 (de) Subkutaner druckstrahlinjektor
EP0384882A3 (de) Einspritzverlaufregelung der Kraftstoffeinspritzventile vom Speichertyp
CA2481434A1 (en) Needleless syringe for the subcutaneous injection of droplets of liquid substances
DE3875935D1 (de) Kraftstoffeinspritzpumpe.
EP0316428A4 (de) Verteiler einer hypodermischen flüssigkeit.
CN86206138U (zh) 无针注射器
RU2708948C1 (ru) Гидравлический безыгольный инъектор
SU1144705A1 (ru) Безыгольный инъектор

Legal Events

Date Code Title Description
8364 No opposition during term of opposition