DE69329594D1 - Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung - Google Patents

Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung

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Publication number
DE69329594D1
DE69329594D1 DE69329594T DE69329594T DE69329594D1 DE 69329594 D1 DE69329594 D1 DE 69329594D1 DE 69329594 T DE69329594 T DE 69329594T DE 69329594 T DE69329594 T DE 69329594T DE 69329594 D1 DE69329594 D1 DE 69329594D1
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Germany
Prior art keywords
oligomers
controlled release
biodegradable
hydrogels
polymerized
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Expired - Lifetime
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DE69329594T
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English (en)
Other versions
DE69329594T2 (de
Inventor
Jeffrey A Hubbell
Chandrashekhar P Pathak
Amarpreet S Sawhney
Neil P Desai
Jennifer L Hill
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University of Texas System
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University of Texas System
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    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/30Synthetic polymers
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    • C12N2533/70Polysaccharides
    • C12N2533/74Alginate
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
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    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2913Rod, strand, filament or fiber
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
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    • Y10T428/2913Rod, strand, filament or fiber
    • Y10T428/2933Coated or with bond, impregnation or core
    • Y10T428/2964Artificial fiber or filament
    • Y10T428/2967Synthetic resin or polymer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/31504Composite [nonstructural laminate]
    • Y10T428/31786Of polyester [e.g., alkyd, etc.]
DE69329594T 1992-02-28 1993-03-01 Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung Expired - Lifetime DE69329594T2 (de)

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Families Citing this family (454)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843156A (en) * 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
JPH06505656A (ja) * 1991-02-13 1994-06-30 フュージョン メデイカル テクノロジーズ インコーポレーテッド 組織溶接用充填剤材料
US5669934A (en) * 1991-02-13 1997-09-23 Fusion Medical Technologies, Inc. Methods for joining tissue by applying radiofrequency energy to performed collagen films and sheets
JP3011768B2 (ja) * 1992-02-28 2000-02-21 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 組織接触材料および制御放出キャリアとしての光重合性生分解性親水ゲル
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US20020095164A1 (en) * 1997-06-26 2002-07-18 Andreas Bernard H. Device and method for suturing tissue
US5749968A (en) * 1993-03-01 1998-05-12 Focal, Inc. Device for priming for improved adherence of gels to substrates
US5800373A (en) * 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US6004547A (en) * 1997-09-29 1999-12-21 Focal, Inc. Apparatus and method for local application of polymeric material to tissue
ATE173171T1 (de) * 1993-03-23 1998-11-15 Focal Inc Gerät und methode für den lokalen auftrag von polymermaterial auf gewebe
US6037329A (en) 1994-03-15 2000-03-14 Selective Genetics, Inc. Compositions containing nucleic acids and ligands for therapeutic treatment
US5665063A (en) 1994-06-24 1997-09-09 Focal, Inc. Methods for application of intraluminal photopolymerized gels
USRE38827E1 (en) 1994-07-27 2005-10-11 3M Innovative Properties Company Adhesive sealant composition
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
US5931165A (en) * 1994-09-06 1999-08-03 Fusion Medical Technologies, Inc. Films having improved characteristics and methods for their preparation and use
US6911216B1 (en) 1994-10-12 2005-06-28 Genzyme Corporation Targeted delivery via biodegradable polymers
WO1996011671A1 (en) * 1994-10-12 1996-04-25 Focal, Inc. Targeted delivery via biodegradable polymers
US5618850A (en) 1995-03-09 1997-04-08 Focal, Inc. Hydroxy-acid cosmetics
AU709527B2 (en) 1995-03-23 1999-09-02 Board Of Regents, The University Of Texas System Redox and photoinitiator systems for priming for improved adherence of gels to substrates
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
ATE306903T1 (de) * 1995-03-24 2005-11-15 Genzyme Corp Verminderung von adhäsionen durch gesteuerte verabreichung von aktivsauerstoffinhibitoren
US5779673A (en) * 1995-06-26 1998-07-14 Focal, Inc. Devices and methods for application of intraluminal photopolymerized gels
EP0842209B1 (de) 1995-07-28 2006-10-11 Genzyme Corporation Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
AU7398196A (en) * 1995-10-11 1997-04-30 Fusion Medical Technologies, Inc. Device and method for sealing tissue
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
AU737078C (en) 1996-05-24 2002-05-02 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
US5791352A (en) * 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
ATE238068T1 (de) 1996-07-01 2003-05-15 Univ Utrecht Hydrolysierbare hydrogele zur gesteuerten freisetzung
US20080131512A1 (en) * 1996-07-01 2008-06-05 Wilhelmus Everhardus Hennink Biodegradable hydrogels
US6696499B1 (en) * 1996-07-11 2004-02-24 Life Medical Sciences, Inc. Methods and compositions for reducing or eliminating post-surgical adhesion formation
US5945100A (en) * 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
US5980948A (en) * 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US20090324721A1 (en) * 1996-09-23 2009-12-31 Jack Kennedy Hydrogels Suitable For Use In Polyp Removal
US6566406B1 (en) * 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
US7009034B2 (en) 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US8003705B2 (en) 1996-09-23 2011-08-23 Incept Llc Biocompatible hydrogels made with small molecule precursors
AU4648697A (en) * 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
JP4803853B2 (ja) * 1996-09-23 2011-10-26 ジェンザイム・コーポレーション カーボネートまたはジオキサノン結合を含む重合可能な生体分解性のポリマー
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
DE19646782C2 (de) * 1996-11-13 2000-05-25 Merck Patent Gmbh Bioresorbierbare Polymerisationsprodukte aus strahlungshärtbaren Bindemittelsystemen
US6743248B2 (en) 1996-12-18 2004-06-01 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
WO1998029506A1 (en) 1996-12-31 1998-07-09 Kimberly-Clark Worldwide, Inc. Water-responsive polymer compositions and method of making the same
US20030191496A1 (en) 1997-03-12 2003-10-09 Neomend, Inc. Vascular sealing device with microwave antenna
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US20040176801A1 (en) * 1997-03-12 2004-09-09 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6127520A (en) 1997-04-15 2000-10-03 Regents Of The University Of Michigan Compositions and methods for the inhibition of neurotransmitter uptake of synaptic vesicles
GB2325467B (en) * 1997-05-21 2000-11-01 Dainippon Ink & Chemicals Process for producing material with hydrophilic surface
CA2291622C (en) 1997-06-06 2007-09-04 Anna Gutowska Reversible geling co-polymer and method of making
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
US6153211A (en) 1997-07-18 2000-11-28 Infimed, Inc. Biodegradable macromers for the controlled release of biologically active substances
EP1512395A1 (de) * 1997-07-18 2005-03-09 Azopax Therapeutics LLC Biologisch abbaubare Makromere zur kontrollierten Abgabe biologisch aktiver Substanzen
US5945480A (en) * 1997-07-31 1999-08-31 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable fibers comprising polylactide modified polylactide and polyvinyl alcohol, and method for making the fibers
US5952433A (en) * 1997-07-31 1999-09-14 Kimberly-Clark Worldwide, Inc. Modified polyactide compositions and a reactive-extrusion process to make the same
US6096303A (en) * 1997-07-31 2000-08-01 Medical College Of Georgia Research Institute, Inc. Method to enhance treatment of cystic tumors
US6552162B1 (en) 1997-07-31 2003-04-22 Kimberly-Clark Worldwide, Inc. Water-responsive, biodegradable compositions and films and articles comprising a blend of polylactide and polyvinyl alcohol and methods for making the same
AU8681098A (en) 1997-08-01 1999-03-08 Massachusetts Institute Of Technology Three-dimensional polymer matrices
US6162241A (en) * 1997-08-06 2000-12-19 Focal, Inc. Hemostatic tissue sealants
US6306642B1 (en) * 1997-11-24 2001-10-23 Quidel Corporation Enzyme substrate delivery and product registration in one step enzyme immunoassays
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US6841617B2 (en) * 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US7087244B2 (en) * 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US20040228794A1 (en) * 1998-04-10 2004-11-18 Battelle Memorial Institute Therapeutic agent carrier compositions
WO1999052469A1 (en) 1998-04-10 1999-10-21 Wm. Marsh Rice University Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger
US6350518B1 (en) 1998-06-01 2002-02-26 Kimberly-Clark Worldwide, Inc. Methods of making blend compositions of an unmodified poly vinyl alcohol and a thermoplastic elastomer
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6632457B1 (en) * 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US7347850B2 (en) * 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6458147B1 (en) 1998-11-06 2002-10-01 Neomend, Inc. Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
DE69931170T2 (de) * 1998-08-26 2007-02-15 Neomend, Inc., Irvine Kit zur in-situ-erzeugung chemisch verbundener mechanischer barrieren oder abdeckstrukturen für eine punktionsstelle in einem blutgefäss
US6994686B2 (en) 1998-08-26 2006-02-07 Neomend, Inc. Systems for applying cross-linked mechanical barriers
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6949114B2 (en) 1998-11-06 2005-09-27 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US6899889B1 (en) 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US6830756B2 (en) * 1998-11-06 2004-12-14 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US7351249B2 (en) * 1998-11-06 2008-04-01 Neomend, Inc. Systems, methods, and compositions for achieving closure of suture sites
US7279001B2 (en) * 1998-11-06 2007-10-09 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
US20080114092A1 (en) * 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6451346B1 (en) * 1998-12-23 2002-09-17 Amgen Inc Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
US7235087B2 (en) 1999-03-04 2007-06-26 Abbott Park Articulating suturing device and method
US7001400B1 (en) 1999-03-04 2006-02-21 Abbott Laboratories Articulating suturing device and method
US7842048B2 (en) 2006-08-18 2010-11-30 Abbott Laboratories Articulating suture device and method
US8137364B2 (en) 2003-09-11 2012-03-20 Abbott Laboratories Articulating suturing device and method
US6964668B2 (en) 1999-03-04 2005-11-15 Abbott Laboratories Articulating suturing device and method
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
AU3877200A (en) 1999-04-12 2000-11-14 Cornell Research Foundation Inc. Hydrogel-forming system with hydrophobic and hydrophilic components
US6716445B2 (en) 1999-04-12 2004-04-06 Cornell Research Foundation, Inc. Hydrogel entrapping therapeutic agent and stent with coating comprising this
KR100696408B1 (ko) * 1999-04-16 2007-03-19 더블유엠. 마쉬 라이스 유니버시티 폴리(에틸렌글리콜)과 가교결합을 이룬 폴리(프로필렌푸마레이트)
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
US6579951B1 (en) * 1999-06-08 2003-06-17 Life Medical Sciences, Inc. Chain-extended or crosslinked polyethylene oxide/polypropylene oxide/polyethylene oxide block polymer with optional polyester blocks
US6521431B1 (en) * 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
JP2003516810A (ja) * 1999-11-15 2003-05-20 バイオキュア・インコーポレーテッド 分解性ポリ(ビニルアルコール)ヒドロゲル
US6710126B1 (en) 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
DE60141567D1 (de) * 2000-01-25 2010-04-29 Edwards Lifesciences Corp Freisetzungssysteme zur behandlung von restenose und anastomotischer intimaler hyperplasie
AU2001231196A1 (en) 2000-01-27 2001-08-07 The General Hospital Corporation Delivery of therapeutic biological from implantable tissue matrices
AU785288B2 (en) * 2000-01-28 2006-12-21 Azopax Therapeutics Llc Slow release protein polymers
US6547806B1 (en) 2000-02-04 2003-04-15 Ni Ding Vascular sealing device and method of use
US7039453B2 (en) * 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
AU4361601A (en) * 2000-03-13 2001-09-24 Biocure Inc Hydrogel biomedical articles
ES2551164T3 (es) 2000-03-24 2015-11-16 Biosphere Medical, Inc. Microesferas para embolización activa
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
US6689165B2 (en) 2000-03-31 2004-02-10 Board Of Supervisors Of Louisana State University And Agricultural And Mechanical College Surface modifications for enhanced epithelialization
US6884778B2 (en) * 2000-04-14 2005-04-26 William Marsh Rice University Biocompatible macromers
US6800671B1 (en) 2000-04-21 2004-10-05 Britesmile, Inc. Low peak exotherm curable compositions
AU2001261300A1 (en) * 2000-05-09 2001-11-20 Pearl Technology Holdings, Llc Biodegradable fiber optic
WO2001088025A1 (en) * 2000-05-16 2001-11-22 Biocure, Inc. Membranes formed from amphiphilic copolymers
US6998115B2 (en) 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US7427394B2 (en) * 2000-10-10 2008-09-23 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
USRE43612E1 (en) 2000-10-10 2012-08-28 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US6686431B2 (en) * 2000-11-01 2004-02-03 Avery Dennison Corporation Optical coating having low refractive index
US7625580B1 (en) 2000-11-28 2009-12-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
WO2002051383A2 (en) 2000-12-27 2002-07-04 Genzyme Corporation Controlled release of anti-arrhythmic agents from a biodegradable polyethylene oxide hydrogel for local application to the heart
US6537569B2 (en) * 2001-02-14 2003-03-25 Microvention, Inc. Radiation cross-linked hydrogels
EP1370249A4 (de) * 2001-02-26 2006-05-03 Univ Duke Neue dendriticpolymere und ihre biomedizinischen anwendungen
AU2002240976A1 (en) * 2001-03-16 2002-10-03 Delsitech Oy Treatment of sols, gels, mixtures or composites of sols and gels, and/or sol-gel derived materials
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US6685956B2 (en) 2001-05-16 2004-02-03 The Research Foundation At State University Of New York Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles for medical applications
US8101196B2 (en) * 2001-06-26 2012-01-24 Biointeractions, Ltd. Polysaccharide biomaterials and methods of use thereof
WO2003031483A1 (en) 2001-10-10 2003-04-17 The Regents Of The University Of Colorado Degradable thiol-ene polymers
DE10152407A1 (de) * 2001-10-24 2003-05-08 Aesculap Ag & Co Kg Zusammensetzung aus mindestens zwei biokompatiblen chemisch vernetzbaren Komponenten
US7112361B2 (en) * 2001-10-25 2006-09-26 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof
US7842498B2 (en) * 2001-11-08 2010-11-30 Bio-Rad Laboratories, Inc. Hydrophobic surface chip
US7629388B2 (en) * 2001-11-20 2009-12-08 William Marsh Rice University Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
DE60232688D1 (de) 2001-11-20 2009-07-30 Univ Duke Grenzflächen-biomaterialien
KR100527408B1 (ko) * 2002-01-03 2005-11-09 한국과학기술원 카프로락톤과 락티드의 랜덤공중합체와 폴리에테르를이용한 생분해성 블록공중합체의 제조방법 및 이의 응용
US7163557B2 (en) * 2002-01-16 2007-01-16 D Eredita Riccardo Biodegradable auricular prosthetic device
US20030147958A1 (en) * 2002-01-29 2003-08-07 Cheol-Hee Ahn Biodegradable multi-block copolymers of poly(amino acid)s and poly(ethylene glycol) for the delivery of bioactive agents
EP1469893A1 (de) * 2002-02-01 2004-10-27 Sustech GmbH & Co. KG Sternformige prapolymere fur die herstellung ultradunner hydrogel-bildender beschichtungen
WO2003071986A2 (en) * 2002-02-22 2003-09-04 Control Delivery Systems, Inc. Method for treating otic disorders
US20040131582A1 (en) * 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
EP1490083A1 (de) * 2002-03-29 2004-12-29 The Regents of the University of California Mikrogelteilchen zur abgabe von biologisch wirksamen materialien
US7329414B2 (en) * 2002-05-03 2008-02-12 Biopsy Sciences, Llc Biodegradable polymer for marking tissue and sealing tracts
US6793678B2 (en) 2002-06-27 2004-09-21 Depuy Acromed, Inc. Prosthetic intervertebral motion disc having dampening
CA2491128A1 (en) * 2002-07-02 2004-01-15 The Regents Of The University Of California Treatment for eye disorder
US20040137039A1 (en) * 2002-07-22 2004-07-15 Trustees Of Stevens Institute Of Technology Methods for controlled release of molecules from layered polymer films
US20050008828A1 (en) * 2002-07-25 2005-01-13 Trustees Of Stevens Institute Of Technology Patterned polymer microgel and method of forming same
WO2004017915A2 (en) * 2002-08-20 2004-03-04 Exactech, Inc. Composition for the carrying and delivery of bone growth inducing material and methods for producing and applying the composition
KR100552954B1 (ko) * 2002-09-04 2006-02-20 주식회사 바이오레인 열감응성 유착방지용 조성물, 용액, 필름, 스폰지 및 분말
US7217254B2 (en) 2002-09-20 2007-05-15 Genzyme Corporation Multi-pressure biocompatible agent delivery device and method
US7862831B2 (en) * 2002-10-09 2011-01-04 Synthasome, Inc. Method and material for enhanced tissue-biomaterial integration
US8673333B2 (en) * 2002-09-25 2014-03-18 The Johns Hopkins University Cross-linked polymer matrices, and methods of making and using same
US20050069572A1 (en) * 2002-10-09 2005-03-31 Jennifer Elisseeff Multi-layered polymerizing hydrogels for tissue regeneration
NZ539713A (en) 2002-10-11 2008-07-31 Novocell Inc Implantation of encapsulated biological materials for treating diseases
US8105652B2 (en) * 2002-10-24 2012-01-31 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof
DE10253391A1 (de) * 2002-11-15 2004-06-03 Mnemoscience Gmbh Amorphe polymere Netzwerke
AU2003284634A1 (en) * 2002-11-21 2004-06-15 Chugai Seiyaku Kabushiki Kaisha Sustained release drug carrier
US7160309B2 (en) 2002-12-31 2007-01-09 Laveille Kao Voss Systems for anchoring a medical device in a body lumen
US20040151691A1 (en) 2003-01-30 2004-08-05 Oxman Joel D. Hardenable thermally responsive compositions
US20040185013A1 (en) * 2003-01-30 2004-09-23 Burgio Paul A. Dental whitening compositions and methods
US7223826B2 (en) 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
CN1446833A (zh) * 2003-02-08 2003-10-08 复旦大学 一种温敏性可降解微凝胶及其制备方法
AU2004212942A1 (en) 2003-02-14 2004-09-02 Depuy Spine, Inc. In-situ formed intervertebral fusion device
US7273896B2 (en) 2003-04-10 2007-09-25 Angiotech Pharmaceuticals (Us), Inc. Compositions and methods of using a transient colorant
US7585499B2 (en) * 2003-04-10 2009-09-08 Surmodics, Inc. Method for encapsulation of cellular material using a charged initiator polymer
US7820158B2 (en) * 2003-04-10 2010-10-26 Surmodics, Inc. Ligand-coupled initiator polymers and methods of use
US20040267367A1 (en) 2003-06-30 2004-12-30 Depuy Acromed, Inc Intervertebral implant with conformable endplate
US20060014003A1 (en) * 2003-07-24 2006-01-19 Libera Matthew R Functional nano-scale gels
US7943179B2 (en) * 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
US20050123596A1 (en) * 2003-09-23 2005-06-09 Kohane Daniel S. pH-triggered microparticles
US7462188B2 (en) 2003-09-26 2008-12-09 Abbott Laboratories Device and method for suturing intracardiac defects
US20050163714A1 (en) * 2003-10-02 2005-07-28 Sukhishvili Svetlana A. Capsules of multilayered neutral polymer films associated by hydrogen bonding
EP1689441A1 (de) 2003-11-05 2006-08-16 PhotoBioMed Corporation Verbindung von geweben und vernetzung von proteinen mit naphthalimid-verbindungen
WO2005061018A1 (en) 2003-12-22 2005-07-07 Regentis Biomaterials Ltd. Matrix comprising naturally-occurring protein backbone
US7842667B2 (en) * 2003-12-22 2010-11-30 Regentis Biomaterials Ltd. Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same
US7449024B2 (en) 2003-12-23 2008-11-11 Abbott Laboratories Suturing device with split arm and method of suturing tissue
WO2005072764A2 (en) * 2004-01-16 2005-08-11 Novocell, Inc. Fibrin-bound angiogenic factors to stimulate vascularization of transplant site of encapsulated cells
FR2865737B1 (fr) * 2004-02-03 2006-03-31 Anteis Sa Gel reticule biocompatible
US20050202096A1 (en) * 2004-03-09 2005-09-15 Jun Li Microcapsules for encapsulation of bioactive substances
WO2005092286A2 (en) * 2004-03-29 2005-10-06 The University Of Houston System Metallic nano-particles and discrete polymer-coated nano-particles
CA2563347C (en) 2004-04-20 2014-01-14 Genzyme Corporation Surgical mesh-like implant
US7727544B2 (en) * 2004-05-07 2010-06-01 The Regents Of The University Of California Treatment of myopia
US20060067977A1 (en) 2004-09-28 2006-03-30 Atrium Medical Corporation Pre-dried drug delivery coating for use with a stent
US8367099B2 (en) 2004-09-28 2013-02-05 Atrium Medical Corporation Perforated fatty acid films
US8312836B2 (en) 2004-09-28 2012-11-20 Atrium Medical Corporation Method and apparatus for application of a fresh coating on a medical device
US9801982B2 (en) 2004-09-28 2017-10-31 Atrium Medical Corporation Implantable barrier device
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
WO2006036964A2 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Barrier layer
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
US20090088846A1 (en) * 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
US20060135725A1 (en) * 2004-12-21 2006-06-22 Scimed Life Systems, Inc. New balloon materials
US9707252B2 (en) * 2005-02-09 2017-07-18 Covidien Lp Synthetic sealants
WO2006089119A2 (en) * 2005-02-18 2006-08-24 Cartilix, Inc. Biological adhesive
BRPI0608186A2 (pt) 2005-02-18 2011-01-04 Synthasome Inc estrutura sintética para reparo de tecidos moles
US8157807B2 (en) 2005-06-02 2012-04-17 The Invention Science Fund I, Llc Skin treatment including patterned light
US20060276859A1 (en) * 2005-06-02 2006-12-07 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Photopatterning of skin
US9180196B2 (en) 2005-03-11 2015-11-10 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
US8343710B1 (en) 2005-03-11 2013-01-01 The Regents Of The University Of Colorado, A Body Corporate Photodegradable groups for tunable polymeric materials
EP1863404A2 (de) 2005-03-30 2007-12-12 Cartilix, Inc. Beschichtete medizinische vorrichtung
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
EP1712903B1 (de) * 2005-04-11 2015-07-15 Roche Diagnostics GmbH Verfahren für integrierte 2D-Gelelektrophorese
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
EP1874728B1 (de) * 2005-04-28 2014-03-19 Nippon Shokubai Co.,Ltd. Zusammensetzung mit tertiärem n-alkenyl-carboxylsäureamid
US8414907B2 (en) 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
ES2568782T3 (es) 2005-05-09 2016-05-04 Biosphere Medical, S.A. Composiciones y métodos de uso de microesferas y agentes de contraste no iónicos
US8728493B2 (en) * 2005-06-17 2014-05-20 Nektar Therapeutics Polymer based compositions and conjugates of non-steroidal anti-inflammatory drugs
US20070038270A1 (en) * 2005-07-05 2007-02-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multi step photopatterning of skin
US7666963B2 (en) * 2005-07-21 2010-02-23 Akzo Nobel N.V. Hybrid copolymers
WO2007016622A2 (en) * 2005-08-02 2007-02-08 Wright Medical Technolody, Inc. Gel composition for inhibiting cellular adhesion
US8083754B2 (en) 2005-08-08 2011-12-27 Abbott Laboratories Vascular suturing device with needle capture
US7883517B2 (en) 2005-08-08 2011-02-08 Abbott Laboratories Vascular suturing device
WO2007019016A1 (en) 2005-08-08 2007-02-15 Abbott Laboratories Vascular suturing device
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US20070060895A1 (en) 2005-08-24 2007-03-15 Sibbitt Wilmer L Jr Vascular closure methods and apparatuses
US20070048340A1 (en) * 2005-08-31 2007-03-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Multi step patterning of a skin surface
KR20080080481A (ko) * 2005-09-02 2008-09-04 콜바르 라이프사이언스 리미티드 교차-결합된 다당류 및 단백질 매트릭스 및 그의 제조 방법
WO2007038982A1 (en) * 2005-09-27 2007-04-12 Universite Joseph Fourier - Grenoble 1 Hydrogel functionalized with a polymerizable moiety and their uses as biosensors or bioreactors
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
EP1951279B1 (de) 2005-10-08 2017-04-12 Apellis Pharmaceuticals, Inc. Compstatin und seine analoga zur behandlung von augenerkrankungen
CA2626030A1 (en) 2005-10-15 2007-04-26 Atrium Medical Corporation Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings
WO2007065074A2 (en) * 2005-11-29 2007-06-07 Indiana University Research And Technology Corporation Biodegradable implant polymers and composites
EP1801573A1 (de) * 2005-12-21 2007-06-27 Boehringer Mannheim Gmbh Vorrichtung und Verfahren für Parallele Zweidimensional-Elektrophorese
US8080059B2 (en) * 2006-01-13 2011-12-20 Fell Barry M Surgically implantable prosthesis with active component
WO2007090130A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Porous intravascular embolization particles and related methods
EP1986707A2 (de) 2006-01-30 2008-11-05 Surgica Corporation Komprimierbare intravaskuläre embolisationsteilchen und relevante verfahren und abgabesysteme
CA2640409C (en) * 2006-02-01 2013-01-29 Samyang Corporation Composition for inhibiting adhesion
WO2007106554A2 (en) * 2006-03-14 2007-09-20 Progen Pharmaceuticals, Inc. Treatment and prevention of vascular hyperplasia using polyamine and polyamine analog compounds
CA2647881C (en) * 2006-04-04 2012-02-14 Saint-Gobain Abrasives, Inc. Infrared cured abrasive articles and method of manufacture
US20070244544A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
EP2023941B1 (de) * 2006-04-24 2016-12-21 Incept, LLC Proteinvernetzer, vernetzungsverfahren und ihre anwendungen
EP2032652A4 (de) * 2006-06-05 2011-08-17 Massachusetts Inst Technology Vernetzte abbaubare polymere und ihre verwendung
US8377091B2 (en) 2006-06-15 2013-02-19 Microvention, Inc. Embolization device constructed from expansile polymer
US8048448B2 (en) 2006-06-15 2011-11-01 Abbott Cardiovascular Systems Inc. Nanoshells for drug delivery
EP2044142A2 (de) * 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester)polymere sowie herstellungs- und verwendungsverfahren dafür
US8674021B2 (en) * 2006-07-21 2014-03-18 Akzo Nobel N.V. Sulfonated graft copolymers
WO2008011561A2 (en) * 2006-07-21 2008-01-24 Massachusetts Institute Of Technology End-modified poly(beta-amino esters) and uses thereof
US20080020961A1 (en) * 2006-07-21 2008-01-24 Rodrigues Klin A Low Molecular Weight Graft Copolymers
US8034110B2 (en) 2006-07-31 2011-10-11 Depuy Spine, Inc. Spinal fusion implant
CA2659612A1 (fr) 2006-08-02 2008-02-07 Khorionyx Preparation implantable, utilisable notamment pour le complement tissulaire et la cicatrisation
CN101522133B (zh) 2006-08-08 2012-08-08 伊纳斯米特基金会 可植入的光学系统,其开发和应用的方法
CN101528876B (zh) * 2006-08-18 2012-08-15 联邦科学及工业研究组织 聚合物涂层及其形成方法
JP2010508897A (ja) 2006-11-06 2010-03-25 アトリウム メディカル コーポレーション コーティングされた外科用メッシュ
US9492596B2 (en) 2006-11-06 2016-11-15 Atrium Medical Corporation Barrier layer with underlying medical device and one or more reinforcing support structures
US20080114096A1 (en) * 2006-11-09 2008-05-15 Hydromer, Inc. Lubricious biopolymeric network compositions and methods of making same
WO2008070863A2 (en) 2006-12-07 2008-06-12 Interventional Spine, Inc. Intervertebral implant
US7935363B2 (en) 2006-12-12 2011-05-03 Synthasome, Inc. Composite material for tissue repair
US20080154233A1 (en) 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
HUE026001T2 (en) 2007-02-05 2016-04-28 Apellis Pharmaceuticals Inc Compstatin analogues for use in the treatment of the inflammatory condition of the respiratory system
US20090227689A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
US20090227981A1 (en) * 2007-03-05 2009-09-10 Bennett Steven L Low-Swelling Biocompatible Hydrogels
WO2008109806A2 (en) * 2007-03-08 2008-09-12 Massachusetts Institute Of Technology Electrostatic coating of particles for drug delivery
US8093039B2 (en) * 2007-04-10 2012-01-10 The Trustees Of The Stevens Institute Of Technology Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells
CA2685807C (en) * 2007-04-13 2016-04-12 Kuros Biosurgery Ag Polymeric tissue sealant
US20080260833A1 (en) * 2007-04-20 2008-10-23 Thomas Hirt Drug delivery vehicle containing vesicles in a hydrogel base
KR100838809B1 (ko) 2007-05-03 2008-06-17 성균관대학교산학협력단 겔강도가 우수한 온도 및 피에치 민감성 블록 공중합체 및이의 제조방법과 이를 이용한 약물전달체
WO2008157372A2 (en) 2007-06-14 2008-12-24 Massachusetts Institute Of Technology Self assembled films for protein and drug delivery applications
US8574244B2 (en) 2007-06-25 2013-11-05 Abbott Laboratories System for closing a puncture in a vessel wall
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US8067028B2 (en) 2007-08-13 2011-11-29 Confluent Surgical Inc. Drug delivery device
KR101552476B1 (ko) 2008-01-17 2015-09-11 신세스 게엠바하 팽창가능한 추간 임플란트 및 관련된 그 제조 방법
US20090192554A1 (en) * 2008-01-29 2009-07-30 Confluent Surgical, Inc. Bioabsorbable block copolymer
KR101809863B1 (ko) 2008-01-30 2017-12-15 아스테리아스 바이오세라퓨틱스, 인크. 줄기 세포 유래 심근세포 배양용 합성 표면
US8329469B2 (en) 2008-01-30 2012-12-11 Geron Corporation Swellable (meth)acrylate surfaces for culturing cells in chemically defined media
EP2240536B1 (de) 2008-01-30 2019-09-04 Asterias Biotherapeutics, Inc. Synthetische oberflächen zur kultivierung von oligodendrozyten-vorläuferzellen aus stammzellen
JP5501981B2 (ja) * 2008-01-30 2014-05-28 ジェロン・コーポレーション 既知組成培地中で細胞を培養するための合成表面
WO2009099539A2 (en) * 2008-01-30 2009-08-13 Corning Incorporated (meth)acrylate surfaces for cell culture, methods of making and using the surfaces
US9441200B2 (en) 2008-02-11 2016-09-13 The Johns Hopkins University Compositions and methods for implantation of adipose tissue and adipose tissue products
US20090238815A1 (en) * 2008-03-18 2009-09-24 Medtronic Vascular, Inc. Nondegradable Hydrogels For Medical Device Application
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
EP2262449B1 (de) 2008-04-05 2020-03-11 Synthes GmbH Expandierbares bandscheibenimplantat
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8940315B2 (en) * 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
JP5591226B2 (ja) 2008-05-12 2014-09-17 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 眼内薬物送達装置および関連する方法
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
EP2293784B1 (de) 2008-06-03 2016-04-13 Indivior UK Limited Fliessfähige zubereitungsform aus einem dehydrierten hydrogel und einem einschlusskomplex einer bioaktiven verbindung
US8883915B2 (en) 2008-07-07 2014-11-11 Biomimedica, Inc. Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
WO2010017282A1 (en) 2008-08-05 2010-02-11 Biomimedica, Inc. Polyurethane-grafted hydrogels
US9271706B2 (en) 2008-08-12 2016-03-01 Covidien Lp Medical device for wound closure and method of use
US9198875B2 (en) * 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
US9889230B2 (en) 2008-10-17 2018-02-13 Covidien Lp Hemostatic implant
CN102143996A (zh) * 2008-10-30 2011-08-03 大卫·刘 微球形多孔可生物相容支架及制造该支架的方法和装置
WO2010060485A1 (de) 2008-11-28 2010-06-03 Zetascience Gmbh Bioaktives hydrogel
WO2010068295A2 (en) * 2008-12-11 2010-06-17 The Board Of Trustees Of The Leland Stanford Junior University Three-dimensionally shaped interpenetrating network hydrogels
KR101040561B1 (ko) 2008-12-26 2011-06-16 아주대학교산학협력단 효소촉발형 생체주입형 하이드로젤과 그 생의학적 용도
TWI374903B (en) * 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
CA2750242C (en) 2009-02-12 2018-05-22 Incept, Llc Drug delivery through hydrogel plugs
US20100227799A1 (en) * 2009-03-09 2010-09-09 Medtronic Vascular, Inc. Simultaneous photodynamic therapy and photo induced polymerization
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
US8362144B2 (en) * 2009-05-21 2013-01-29 Corning Incorporated Monomers for making polymeric cell culture surface
KR101091028B1 (ko) * 2009-07-02 2011-12-09 아주대학교산학협력단 체내 주입형 하이드로젤 및 이의 생의학적 용도
JP2011016896A (ja) * 2009-07-08 2011-01-27 Nippon Bee Chemical Co Ltd 光硬化型植物由来コーティング剤およびそのコーティング物
US9597430B2 (en) 2009-07-31 2017-03-21 Synthasome, Inc. Synthetic structure for soft tissue repair
KR101759499B1 (ko) 2009-07-31 2017-07-19 사노피-아벤티스 도이칠란트 게엠베하 지속형 인슐린 조성물
SG178193A1 (en) 2009-07-31 2012-03-29 Sanofi Aventis Deutschland Prodrugs comprising an insulin linker conjugate
MX343925B (es) 2009-07-31 2016-11-29 Ascendis Pharma As Hidrogeles biodegradables insolubles en agua a base de polietilenglicol.
CN102549034B (zh) 2009-07-31 2014-12-10 阿克佐诺贝尔股份有限公司 用于个人护理方面的杂化共聚物组合物
US20110038910A1 (en) 2009-08-11 2011-02-17 Atrium Medical Corporation Anti-infective antimicrobial-containing biomaterials
US9649331B2 (en) * 2009-08-27 2017-05-16 Ara Medical Llc Sprayable polymers as adhesion barriers
WO2011040969A1 (en) * 2009-09-30 2011-04-07 Massachusetts Institute Of Technology Compositions and methods for the treatment of atherosclerosis and other related diseases
US8470355B2 (en) 2009-10-01 2013-06-25 Covidien Lp Mesh implant
KR101220047B1 (ko) * 2009-10-12 2013-01-08 금호석유화학 주식회사 액정 표시 소자용 실란트 조성물
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
NZ599527A (en) 2009-11-09 2014-04-30 Spotlight Technology Partners Llc Fragmented hydrogels
US9168138B2 (en) 2009-12-09 2015-10-27 DePuy Synthes Products, Inc. Aspirating implants and method of bony regeneration
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
US8889193B2 (en) 2010-02-25 2014-11-18 The Johns Hopkins University Sustained delivery of therapeutic agents to an eye compartment
US9012415B2 (en) 2010-03-26 2015-04-21 Stemmatters, Biotecnologia E Medicina Regenerativa S.A. Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof
US9132209B2 (en) 2010-05-07 2015-09-15 Howmedia Osteonics Corp. Surface crosslinked polyethylene
US9592063B2 (en) 2010-06-24 2017-03-14 DePuy Synthes Products, Inc. Universal trial for lateral cages
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
JP5850930B2 (ja) 2010-06-29 2016-02-03 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 離反椎間インプラント
US10322213B2 (en) 2010-07-16 2019-06-18 Atrium Medical Corporation Compositions and methods for altering the rate of hydrolysis of cured oil-based materials
EP2609135A4 (de) 2010-08-26 2015-05-20 Massachusetts Inst Technology Poly(beta-amino-alkohole), ihre herstellung und verwendungen davon
US9370353B2 (en) 2010-09-01 2016-06-21 Abbott Cardiovascular Systems, Inc. Suturing devices and methods
US8663252B2 (en) 2010-09-01 2014-03-04 Abbott Cardiovascular Systems, Inc. Suturing devices and methods
US10307372B2 (en) 2010-09-10 2019-06-04 The Johns Hopkins University Rapid diffusion of large polymeric nanoparticles in the mammalian brain
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
EP2438930A1 (de) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrug mit einem exendinbindenden Konjugat
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
US20120121718A1 (en) * 2010-11-05 2012-05-17 The Johns Hopkins University Compositions and methods relating to reduced mucoadhesion
EP2799079A1 (de) 2010-11-12 2014-11-05 Allergan, Inc. Verstoffwechseltes konditioniertes Wachstumsmedium und Verwendungsverfahren dafür
US20140038826A1 (en) 2011-01-28 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Covalently cross linked hydrogels and methods of making and using same
US9102914B2 (en) 2011-02-03 2015-08-11 Empire Technology Development Llc 3D trophoblast matrix for preparing organ-specific stem cells
US10064948B2 (en) * 2011-03-09 2018-09-04 Occlugel Implantable bio-resorbable polymer charged with fragile macromolecules
WO2012127224A1 (en) 2011-03-21 2012-09-27 University Of Reading Transport of cells in hydrogels
US9567357B2 (en) 2011-06-24 2017-02-14 Biointeractions Ltd. Biocompatible, biomimetic ampholyte materials
US8636918B2 (en) 2011-08-05 2014-01-28 Ecolab Usa Inc. Cleaning composition containing a polysaccharide hybrid polymer composition and methods of controlling hard water scale
US8853144B2 (en) 2011-08-05 2014-10-07 Ecolab Usa Inc. Cleaning composition containing a polysaccharide graft polymer composition and methods of improving drainage
US8841246B2 (en) 2011-08-05 2014-09-23 Ecolab Usa Inc. Cleaning composition containing a polysaccharide hybrid polymer composition and methods of improving drainage
US8679366B2 (en) 2011-08-05 2014-03-25 Ecolab Usa Inc. Cleaning composition containing a polysaccharide graft polymer composition and methods of controlling hard water scale
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US20130103157A1 (en) 2011-10-03 2013-04-25 Lampros Kourtis Polymeric adhesive for anchoring compliant materials to another surface
CN103889395A (zh) 2011-11-04 2014-06-25 阿克佐诺贝尔化学国际公司 接枝树枝状共聚物及其制备方法
WO2013064647A1 (en) 2011-11-04 2013-05-10 Akzo Nobel Chemicals International B.V. Hybrid dendrite copolymers, compositions thereof and methods for producing the same
CA2856512A1 (en) 2011-11-21 2013-05-30 Biomimedica, Inc. Systems, devices, and methods for anchoring orthopaedic implants to bone
KR101269423B1 (ko) 2011-12-22 2013-05-30 오스템임플란트 주식회사 체내 분해 속도 조절이 가능한 수화젤 및 그 제조 방법
US9988433B2 (en) 2013-03-14 2018-06-05 Mosaic Biosciences, Inc. Covalent modification of biological macromolecules
US9321030B2 (en) 2012-01-04 2016-04-26 The Trustees Of The Stevens Institute Of Technology Clay-containing thin films as carriers of absorbed molecules
WO2013116791A1 (en) 2012-02-02 2013-08-08 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
JP2015509129A (ja) * 2012-02-03 2015-03-26 コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼーション 分岐ポリマー
US9005286B2 (en) 2012-02-21 2015-04-14 Thierry Giorno PLGA/HA hydroxyapatite composite bone grafts and method of making
US10159743B2 (en) 2012-03-16 2018-12-25 The Johns Hopkins University Non-linear multiblock copolymer-drug conjugates for the delivery of active agents
US8962577B2 (en) 2012-03-16 2015-02-24 The Johns Hopkins University Controlled release formulations for the delivery of HIF-1 inhibitors
US8858573B2 (en) 2012-04-10 2014-10-14 Abbott Cardiovascular Systems, Inc. Apparatus and method for suturing body lumens
US8864778B2 (en) 2012-04-10 2014-10-21 Abbott Cardiovascular Systems, Inc. Apparatus and method for suturing body lumens
US10278927B2 (en) 2012-04-23 2019-05-07 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
US9056057B2 (en) 2012-05-03 2015-06-16 Kala Pharmaceuticals, Inc. Nanocrystals, compositions, and methods that aid particle transport in mucus
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
KR102154880B1 (ko) 2012-05-03 2020-09-10 칼라 파마슈티컬스, 인크. 개선된 점막 수송을 나타내는 제약 나노입자
JP6392209B2 (ja) 2012-05-04 2018-09-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 粘液内層を通過する迅速な透過のための脂質ベース薬物キャリア
US9241707B2 (en) 2012-05-31 2016-01-26 Abbott Cardiovascular Systems, Inc. Systems, methods, and devices for closing holes in body lumens
US9867880B2 (en) 2012-06-13 2018-01-16 Atrium Medical Corporation Cured oil-hydrogel biomaterial compositions for controlled drug delivery
US10549112B2 (en) 2012-07-20 2020-02-04 The General Hospital Corporation Apparatus for tissue irradiation and methods and kits utilizing the same
WO2014015274A1 (en) 2012-07-20 2014-01-23 The General Hospital Corporation Methods for tissue passivation
US10292381B2 (en) 2012-07-20 2019-05-21 The General Hospital Corporation Vessel treatment systems, methods, and kits
US8945314B2 (en) 2012-07-30 2015-02-03 Ecolab Usa Inc. Biodegradable stability binding agent for a solid detergent
JP2016501931A (ja) 2012-11-21 2016-01-21 ユニバーシティー オブ ルイヴィル リサーチ ファウンデーション,インコーポレーテッドUniversity Of Louisville Research Foundation,Inc. 酸化的損傷を減じるための組成物および方法
US10568975B2 (en) 2013-02-05 2020-02-25 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
KR20150117274A (ko) 2013-02-12 2015-10-19 카본3디, 인크. 3차원 제작을 위한 방법 및 장치
MX352989B (es) 2013-02-12 2017-12-14 Carbon3D Inc Impresión de interfase líquida continua.
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
US10624865B2 (en) 2013-03-14 2020-04-21 Pathak Holdings Llc Methods, compositions, and devices for drug/live cell microarrays
US9463244B2 (en) 2013-03-15 2016-10-11 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
CA3105562C (en) 2013-04-26 2023-03-07 Biointeractions Limited Bioactive coatings
USRE49528E1 (en) 2013-04-26 2023-05-16 Biointeractions Ltd. Bioactive coatings
AU2014290513B2 (en) 2013-07-18 2017-07-27 The General Hospital Corporation Vessel treatment systems, methods, and kits
WO2015042462A1 (en) 2013-09-19 2015-03-26 Microvention, Inc. Polymer films
CA2923753C (en) 2013-09-19 2021-10-12 Terumo Corporation Polymer particles
CN105916495B (zh) 2013-11-08 2019-11-12 泰尔茂株式会社 聚合物颗粒
US10232605B2 (en) 2014-03-21 2019-03-19 Carbon, Inc. Method for three-dimensional fabrication with gas injection through carrier
EP3134250B1 (de) 2014-04-25 2023-11-15 Carbon, Inc. Kontinuierliche dreidimensionale herstellung aus nicht mischbaren flüssigkeiten
WO2015167752A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers including active agents
US9365805B2 (en) 2014-05-15 2016-06-14 Ecolab Usa Inc. Bio-based pot and pan pre-soak
WO2015195909A1 (en) 2014-06-20 2015-12-23 Carbon3D, Inc. Three-dimensional printing using tiled light engines
DK3157738T3 (en) 2014-06-20 2019-03-11 Carbon Inc THREE-DIMENSIONAL PRINTING WITH RECIPE SUPPLY OF POLYMERIZABLE LIQUID
WO2015195920A1 (en) 2014-06-20 2015-12-23 Carbon3D, Inc. Three-dimensional printing method using increased light intensity and apparatus therefore
CA2950215A1 (en) 2014-06-23 2015-12-30 Carbon, Inc. Polyurethane resins having multiple mechanisms of hardening for use in producing three-dimensional objects
CA2955357A1 (en) 2014-07-17 2016-01-21 The Regents Of The University Of California Self-annealing microgel particles for biomedical applications
US11390062B2 (en) 2014-08-12 2022-07-19 Carbon, Inc. Three-dimensional printing with supported build plates
EP3011952A1 (de) 2014-10-24 2016-04-27 Centre National De La Recherche Scientifique -Cnrs- Zeitgesteuerte, glucosefreisetzende Hydrogels und Anwendungen davon
TW201625754A (zh) * 2014-11-21 2016-07-16 艾倫塔斯有限公司 單一成份、儲存穩定、可硬化之聚矽氧組成物
CN105131315B (zh) 2014-11-27 2017-08-29 上海戴云化工科技有限公司 非自由基光化学交联水凝胶材料制备方法、其产品及应用
US20170355132A1 (en) 2014-12-31 2017-12-14 Carbon, Inc. Three-dimensional printing of objects with breathing orifices
WO2016112084A1 (en) 2015-01-06 2016-07-14 Carbon3D, Inc. Build plate for three dimensional printing having a rough or patterned surface
WO2016112090A1 (en) 2015-01-07 2016-07-14 Carbon3D, Inc. Microfluidic devices and methods of making the same
WO2016115236A1 (en) 2015-01-13 2016-07-21 Carbon3D, Inc. Three-dimensional printing with build plates having surface topologies for increasing permeability and related methods
JP6846351B2 (ja) 2015-01-27 2021-03-24 ザ・ジョンズ・ホプキンス・ユニバーシティー 粘膜表面における活性薬剤の増強された輸送のための低張ヒドロゲル製剤
WO2016123499A1 (en) 2015-01-30 2016-08-04 Carbon3D, Inc. Build plates for continuous liquid interface printing having permeable base and adhesive for increasing permeability and related methods, systems and devices
WO2016123506A1 (en) 2015-01-30 2016-08-04 Carbon3D, Inc. Build plates for continuous liquid interface printing having permeable sheets and related methods, systems and devices
EP3253558B1 (de) 2015-02-05 2020-04-08 Carbon, Inc. Verfahren zur generativen fertigung durch herstellung durch mehrere zonen
WO2016130478A1 (en) 2015-02-09 2016-08-18 University Of Louisville Research Foundation, Inc. Ophthalmic compositions and methods for reducing oxidative damage to an eye lens
EP3256167B1 (de) 2015-02-09 2020-11-11 Mosaic Biosciences, Inc. Abbaubare thiol-en-polymere und verfahren zur herstellung davon
US11000992B2 (en) 2015-02-20 2021-05-11 Carbon, Inc. Methods and apparatus for continuous liquid interface printing with electrochemically supported dead zone
US11382731B2 (en) 2015-02-27 2022-07-12 Covidien Lp Medical devices with sealing properties
US20180029292A1 (en) 2015-03-05 2018-02-01 Carbon, Inc. Continuous liquid interface production with sequential patterned exposure
US20180015662A1 (en) 2015-03-05 2018-01-18 Carbon, Inc. Fabrication of three dimensional objects with variable slice thickness
US10391711B2 (en) 2015-03-05 2019-08-27 Carbon, Inc. Fabrication of three dimensional objects with multiple operating modes
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
WO2016145050A1 (en) 2015-03-10 2016-09-15 Carbon3D, Inc. Microfluidic devices having flexible features and methods of making the same
WO2016145182A1 (en) 2015-03-12 2016-09-15 Carbon3D, Inc. Additive manufacturing using polymerization initiators or inhibitors having controlled migration
WO2016149097A1 (en) 2015-03-13 2016-09-22 Carbon3D, Inc. Three-dimensional printing with reduced pressure build plate unit
WO2016149151A1 (en) 2015-03-13 2016-09-22 Carbon3D, Inc. Three-dimensional printing with concurrent delivery of different polymerizable liquids
WO2016149104A1 (en) 2015-03-13 2016-09-22 Carbon3D, Inc. Three-dimensional printing with flexible build plates
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
AU2016261925B2 (en) 2015-05-12 2020-10-01 Incept, Llc Drug delivery from hydrogels
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
CN106620893B (zh) * 2015-07-23 2021-07-30 爱博诺德(北京)医疗科技股份有限公司 用于眼部疾病光治疗的材料
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
CN108367495B (zh) 2015-09-25 2021-06-15 卡本有限公司 用于连续液体相间打印的具有发光面板的构造板组合件和相关方法、系统及装置
WO2017059082A1 (en) 2015-09-30 2017-04-06 Carbon, Inc. Method and apparatus for producing three-dimensional objects
GB201519811D0 (en) * 2015-11-10 2015-12-23 Univ Belfast Ocular compositions
US10647054B2 (en) 2015-12-22 2020-05-12 Carbon, Inc. Accelerants for additive manufacturing with dual cure resins
WO2017112653A1 (en) 2015-12-22 2017-06-29 Carbon, Inc. Dual precursor resin systems for additive manufacturing with dual cure resins
WO2017112521A1 (en) 2015-12-22 2017-06-29 Carbon, Inc. Production of flexible products by additive manufacturing with dual cure resins
US10538031B2 (en) 2015-12-22 2020-01-21 Carbon, Inc. Dual cure additive manufacturing of rigid intermediates that generate semi-rigid, flexible, or elastic final products
JP6944935B2 (ja) 2015-12-22 2021-10-06 カーボン,インコーポレイテッド 二重硬化樹脂を用いた積層造形による複数の中間体からの複合生産物の製作
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels
KR102368890B1 (ko) 2016-05-17 2022-04-29 라이브니츠-인스티튜트 퓌어 폴리머포르슝 드레스덴 에.파우. 인간 뉴런 세포 및 신경교 세포의 기능성 네트워크를 형성하기 위한 방법
AU2017273542B2 (en) 2016-05-31 2023-07-06 Northwestern University Method for the fabrication of three-dimensional objects and apparatus for same
CN109640889B (zh) 2016-06-28 2021-07-30 Eit 新兴移植技术股份有限公司 可扩张的角度可调节式关节运动椎间保持架
US11510788B2 (en) 2016-06-28 2022-11-29 Eit Emerging Implant Technologies Gmbh Expandable, angularly adjustable intervertebral cages
CN109153173B (zh) 2016-07-01 2021-08-24 卡本有限公司 用于通过建造板脱气来减少气泡的三维打印方法和设备
GB2562443B (en) * 2016-08-05 2021-01-13 Lancaster Univ Business Enterprises Limited Injectable composition
US10590257B2 (en) 2016-09-26 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Biomimetic, moldable, self-assembled cellulose silica-based trimeric hydrogels and their use as viscosity modifying carriers in industrial applications
CN109789239B (zh) 2016-09-28 2021-01-22 泰尔茂株式会社 聚合物颗粒
CN110023056B (zh) 2016-11-21 2021-08-24 卡本有限公司 通过递送反应性组分用于后续固化来制造三维物体的方法
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
CN117582559A (zh) 2016-12-29 2024-02-23 泰普治疗公司 用于治疗医疗植入物部位的方法和系统
US10426449B2 (en) 2017-02-16 2019-10-01 Abbott Cardiovascular Systems, Inc. Articulating suturing device with improved actuation and alignment mechanisms
US10239255B2 (en) 2017-04-11 2019-03-26 Molecule Corp Fabrication of solid materials or films from a polymerizable liquid
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
WO2019084229A1 (en) 2017-10-27 2019-05-02 Massachusetts Institute Of Technology POLY (BETA-AMINO ESTERS) AND USES THEREOF
WO2019089567A1 (en) 2017-10-30 2019-05-09 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
CN107875444B (zh) * 2017-11-03 2021-01-05 西安工业大学 用于心脏修复的生物降解性的水凝胶支架材料的制备方法
CN109776451B (zh) * 2017-11-15 2020-12-11 中山光禾医疗科技有限公司 光交联水凝胶材料的制备、原料、产品及应用
JP7000819B2 (ja) * 2017-11-27 2022-01-19 東洋紡株式会社 光硬化性爪被覆剤
JP7264222B2 (ja) * 2017-11-27 2023-04-25 東洋紡株式会社 光硬化性爪被覆剤
JP7423070B2 (ja) 2018-04-06 2024-01-29 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 増加した溶解度および改善された薬物動態特性を有するコンプスタチンアナログ
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
WO2020086965A1 (en) 2018-10-26 2020-04-30 Massachusetts Institute Of Technology Polymer-lipids and compositions
CN109777340B (zh) * 2019-01-24 2020-03-13 中国科学院兰州化学物理研究所 一种水中和空气中均能使用的胶黏剂及其制备方法
KR20220016453A (ko) 2019-04-09 2022-02-09 아줄 쓰리디, 인크. 적층 제조에 의해 생성되는 부분들을 신속하게 경화시키고 코팅하는 방법론들
KR102267782B1 (ko) * 2019-05-09 2021-06-24 창신리빙(주) 욕조에 넣어 사용하는 반신욕 좌대
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage
WO2024047045A1 (en) 2022-08-31 2024-03-07 Mimetis Biomaterials Synthetic bone grafts and methods for their preparation

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3640741A (en) * 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
BE785858A (fr) * 1971-07-06 1973-01-05 Union Carbide Corp Procede chimique de reticulation de poly (oxyde d'alkylene)
US3993071A (en) * 1971-09-09 1976-11-23 Alza Corporation Bioerodible ocular device
US3960150A (en) * 1971-09-09 1976-06-01 Alza Corporation Bioerodible ocular device
US3986510A (en) * 1971-09-09 1976-10-19 Alza Corporation Bioerodible ocular device
US3981303A (en) * 1971-09-09 1976-09-21 Alza Corporation Bioerodible ocular device
GB1446709A (en) * 1972-07-06 1976-08-18 Nat Patent Dev Corp Tooth root canal filling composition
US4450150A (en) * 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
US4193845A (en) * 1973-11-15 1980-03-18 Japan Atomic Energy Research Institute Immobilization of enzymes or bacterial cells
AR205997A1 (es) * 1973-11-21 1976-06-23 American Cyanamid Co Resina de poliester normalmente solida biodegradable e hidrolizable
JPS5126285A (en) * 1974-08-30 1976-03-04 Japan Atomic Energy Res Inst Koso mataha kintaiofukunda soseibutsu no seizohoho
US4076800A (en) * 1975-01-13 1978-02-28 The Procter & Gamble Company Protein-containing detergent compositions for protecting keratinous materials
DE2633259C3 (de) * 1975-07-23 1984-11-15 Japan Atomic Energy Research Institute, Tokio/Tokyo Verfahren zum Unbeweglichmachen von Enzymen oder enzymhaltigen Zellen
US4195129A (en) * 1975-11-26 1980-03-25 Kansai Paint Co., Ltd. Method for immobilizing enzymes and microbial cells
JPS5296791A (en) * 1976-02-09 1977-08-13 Japan Atom Energy Res Inst Preparation of composition including enzymes or microorganisms
US4118470A (en) * 1976-06-01 1978-10-03 American Cyanamid Company Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
US4095600A (en) * 1976-06-01 1978-06-20 American Cyanamid Company Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product
US4298839A (en) * 1978-03-31 1981-11-03 Westinghouse Electric Corp. Programmable AC electric energy meter having radiation responsive external data interface
JPS5589314A (en) * 1978-12-27 1980-07-05 Dainichi Nippon Cables Ltd Method of crosslinking polyvinyl chloride
JPS55110105A (en) * 1979-02-19 1980-08-25 Japan Atom Energy Res Inst Preparation of polymer composition containing physiologically active material
US4295762A (en) * 1979-02-21 1981-10-20 Nalco Chemical Company Grouting-soil conditioning systems using polyoxyethylene diacrylates
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
JPS5611916A (en) * 1979-07-10 1981-02-05 Chisso Corp Production of vinyl chloride copolymer
JPS5622306A (en) * 1979-07-31 1981-03-02 Nitto Kasei Kk Ultraviolet ray-curable resin composition having antistatic effect
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4376839A (en) * 1980-01-21 1983-03-15 Technicon Instruments Corporation Heat stable, polymer-forming composition
NL8001885A (nl) * 1980-03-31 1981-11-02 Akzo Nv Intiator-systeem voor door straling hardbare composities.
JPS56142038A (en) 1980-04-07 1981-11-06 Chisso Corp Extrusion molding of vinyl chloride copolymer
JPS57113118A (en) * 1980-12-30 1982-07-14 Fanuc Ltd Robot control system
US4434150A (en) * 1981-10-19 1984-02-28 Ortho Diagnostic Systems, Inc. Immunological reagents employing polymeric backbone possessing reactive functional groups
US4512910A (en) * 1982-01-28 1985-04-23 Morton Thickol, Inc. Photocurable compositions
EP0092918B1 (de) * 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Mittel mit verzögerter Freigabe
US4452973A (en) * 1982-11-12 1984-06-05 American Cyanamid Company Poly(glycolic acid)/poly(oxyethylene) triblock copolymers and method of manufacturing the same
JPS59184029A (ja) 1983-03-31 1984-10-19 Kanegafuchi Chem Ind Co Ltd 自動車用シフトレバ−ブ−ツ
JPS59191750A (ja) 1983-04-13 1984-10-30 Chisso Corp 塩化ビニル系樹脂組成物
US4806355A (en) * 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4689293A (en) * 1983-06-06 1987-08-25 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4533445A (en) * 1983-07-06 1985-08-06 Shipley Company Inc. U.V. Curable composition
JPS6028950A (ja) 1983-07-27 1985-02-14 T Hasegawa Co Ltd シス−3−アルケン酸類、その製法および利用
US4631188A (en) * 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
US4511478A (en) * 1983-11-10 1985-04-16 Genetic Systems Corporation Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides
US4605622A (en) * 1983-11-15 1986-08-12 Kansai Paint Co., Ltd. Process for producing granular fixed enzymes or microorganisms
JPS60127342A (ja) 1983-12-14 1985-07-08 Chisso Corp 塩化ビニル樹脂組成物
US4655777A (en) * 1983-12-19 1987-04-07 Southern Research Institute Method of producing biodegradable prosthesis and products therefrom
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4663286A (en) * 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4744933A (en) * 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
US4749620A (en) * 1984-02-15 1988-06-07 Massachusetts Institute Of Technology Encapsulated active material system
EP0160260A3 (de) * 1984-05-02 1986-10-08 Bayer Ag Verfahren zur Immobilisierung von biologischem Material
US4650488A (en) * 1984-05-16 1987-03-17 Richards Medical Company Biodegradable prosthetic device
FR2565233B1 (fr) * 1984-05-30 1986-09-12 Rhone Poulenc Rech Copolymere greffe de silicone et de polylactone lie par une liaison urethanne
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
CA1267618A (en) * 1985-03-04 1990-04-10 Roberta C. Cheng Stabilization of intracellular enzymes
US4950596A (en) * 1985-03-04 1990-08-21 The Dow Chemical Company Stabilization of intracellular enzymes
US4741337A (en) * 1985-07-17 1988-05-03 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
CS255758B1 (en) * 1985-12-11 1988-03-15 Frantisek Rypacek Preparat for the diagnostic of transportion function of oviduct and process for preparing thereof
US4889722A (en) * 1985-12-16 1989-12-26 Ethicon, Inc. Method for inhibiting post-surgical adhesion formation by the topical administration of tissue plasminogen activator
US5061281A (en) * 1985-12-17 1991-10-29 Allied-Signal Inc. Bioresorbable polymers and implantation devices thereof
US4741872A (en) * 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US4744365A (en) * 1986-07-17 1988-05-17 United States Surgical Corporation Two-phase compositions for absorbable surgical devices
US4716203A (en) * 1986-09-05 1987-12-29 American Cyanamid Company Diblock and triblock copolymers
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
US4913903A (en) * 1987-02-04 1990-04-03 Alza Corporation Post-surgical applications for bioerodible polymers
JPS63199208A (ja) * 1987-02-12 1988-08-17 Chisso Corp 塩化ビニル樹脂の製造方法
US4933430A (en) * 1987-03-05 1990-06-12 S. C. Johnson & Son, Inc. Process for producing polymers useful in thermoset coatings and polymer so produced
DE3716544A1 (de) * 1987-05-16 1988-11-24 Basf Ag Verwendung von wasserloeslichen copolymerisaten, die monomere mit mindestens zwei ethylenisch ungesaettigten doppelbindungen einpolymerisiert enthalten, in wasch- und reinigungsmitteln
IL82834A (en) * 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4804691A (en) * 1987-08-28 1989-02-14 Richards Medical Company Method for making a biodegradable adhesive for soft living tissue
JPH0192386A (ja) * 1987-10-05 1989-04-11 Hitachi Ltd 密閉循環型吸収式冷凍機及び吸収式冷凍機用吸収液
US5129889A (en) * 1987-11-03 1992-07-14 Hahn John L Synthetic absorbable epidural catheter
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5185408A (en) * 1987-12-17 1993-02-09 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5120802A (en) * 1987-12-17 1992-06-09 Allied-Signal Inc. Polycarbonate-based block copolymers and devices
US4891263A (en) * 1987-12-17 1990-01-02 Allied-Signal Inc. Polycarbonate random copolymer-based fiber compositions and method of melt-spinning same and device
US4916193A (en) * 1987-12-17 1990-04-10 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US4921934A (en) 1987-12-23 1990-05-01 S. C. Johnson & Son, Inc. Alkali-soluble polymers and process for producing same
US4888413A (en) * 1988-01-11 1989-12-19 Domb Abraham J Poly(propylene glycol fumarate) compositions for biomedical applications
JPH0720857B2 (ja) * 1988-08-11 1995-03-08 テルモ株式会社 リポソームおよびその製法
US4925677A (en) * 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
DD277454A1 (de) * 1988-12-02 1990-04-04 Akad Wissenschaften Ddr Verfahren zur beschichtung von glas- und keramikoberflaechen mit elektronenstrahlhaertbaren ueberzuegen
GB8903464D0 (en) * 1989-02-15 1989-04-05 Joint Replacement Instrumentat Coated femoral prosthesis
US4999417A (en) * 1989-03-30 1991-03-12 Nova Pharmaceutical Corporation Biodegradable polymer compositions
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
CA2016740A1 (en) * 1989-05-26 1990-11-26 Shih-Chung Chen Anti-fog coating
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US4994277A (en) * 1989-10-31 1991-02-19 Pfizer Hospital Products Group, Inc. Use of xanthan gum for preventing adhesions
US5049138A (en) 1989-11-13 1991-09-17 Boston Scientific Corporation Catheter with dissolvable tip
JP2651516B2 (ja) * 1989-12-13 1997-09-10 国立循環器病センター総長 ハイブリッド型人工膵臟
US5219564A (en) * 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
ES2077209T3 (es) * 1990-07-12 1995-11-16 Ciba Geigy Ag Procedimiento para la fijacion de colorantes.
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5206303A (en) * 1990-12-27 1993-04-27 Exxon Chemical Patents Inc. Entanglement-inhibited macromolecules
US5153002A (en) * 1991-03-04 1992-10-06 University Of Montreal Biocompatible gradient controlled release implant
JP3184555B2 (ja) 1991-05-28 2001-07-09 松下電工株式会社 吸湿器
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
AU3070892A (en) * 1991-11-12 1993-06-15 Nepera, Inc. Adhesive hydrogels having extended use lives and process for the preparation of same
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US5270400A (en) * 1991-12-31 1993-12-14 Maria Spinu L-Dpolylactide copolymers with controlled morphology
US5417983A (en) * 1992-02-19 1995-05-23 Sagami Chemical Research Center Drug release controlling material responsive to changes in temperature
JP3011768B2 (ja) * 1992-02-28 2000-02-21 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 組織接触材料および制御放出キャリアとしての光重合性生分解性親水ゲル
GB9326511D0 (en) * 1993-12-29 1994-03-02 Solvay Interox Ltd Macromonomer preparation
EP0842209B1 (de) * 1995-07-28 2006-10-11 Genzyme Corporation Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
US5633342A (en) * 1995-10-27 1997-05-27 Chronopol, Inc. Method for the synthesis of environmentally degradable block copolymers
DE19718520C1 (de) 1997-05-02 1998-10-01 Daimler Benz Ag Jalousierahmenanordnung
US6153211A (en) * 1997-07-18 2000-11-28 Infimed, Inc. Biodegradable macromers for the controlled release of biologically active substances
US6007833A (en) * 1998-03-19 1999-12-28 Surmodics, Inc. Crosslinkable macromers bearing initiator groups
JP3294835B2 (ja) 2000-01-31 2002-06-24 ニチハ株式会社 木質セメント板およびその製造方法

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US5986043A (en) 1999-11-16
EP0627911A1 (de) 1994-12-14
AU673160B2 (en) 1996-10-31
WO1993017669A1 (en) 1993-09-16
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JPH07507056A (ja) 1995-08-03
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US6602975B2 (en) 2003-08-05
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US20020091229A1 (en) 2002-07-11
US6306922B1 (en) 2001-10-23
CA2117588C (en) 1998-08-25
US6060582A (en) 2000-05-09
PT627911E (pt) 2001-04-30
JP3011768B2 (ja) 2000-02-21

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