DE69330187D1 - Verwendung einer ionen-selektiven polymermembran zur bestimmung von heparin - Google Patents

Verwendung einer ionen-selektiven polymermembran zur bestimmung von heparin

Info

Publication number: DE69330187D1
Authority: DE; Germany
Prior art keywords: heparin; polymer membrane; ion selective; plasticizer; selective polymer
Prior art date: 1992-03-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69330187T

Other languages

English (en)

Other versions

DE69330187T2 (de

Inventor

Shu-Ching Ma

E Meyerhoff

C Yang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Michigan

Original Assignee

University of Michigan

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-10

Filing date

1993-03-10

Publication date

2001-06-07

1993-03-10 Application filed by University of Michigan filed Critical University of Michigan

2001-06-07 Publication of DE69330187D1 publication Critical patent/DE69330187D1/de

2002-01-31 Application granted granted Critical

2002-01-31 Publication of DE69330187T2 publication Critical patent/DE69330187T2/de

2013-03-11 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

229960002897 heparin Drugs 0.000 title abstract 5
229920000669 heparin Polymers 0.000 title abstract 5
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 4
229920005597 polymer membrane Polymers 0.000 title 1
239000008280 blood Substances 0.000 abstract 2
210000004369 blood Anatomy 0.000 abstract 2
239000011159 matrix material Substances 0.000 abstract 2
239000004014 plasticizer Substances 0.000 abstract 2
238000005349 anion exchange Methods 0.000 abstract 1
239000003011 anion exchange membrane Substances 0.000 abstract 1
238000001514 detection method Methods 0.000 abstract 1
MIMDHDXOBDPUQW-UHFFFAOYSA-N dioctyl decanedioate Chemical compound CCCCCCCCOC(=O)CCCCCCCCC(=O)OCCCCCCCC MIMDHDXOBDPUQW-UHFFFAOYSA-N 0.000 abstract 1
239000012530 fluid Substances 0.000 abstract 1
-1 heparin ions Chemical class 0.000 abstract 1
229920002521 macromolecule Polymers 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
229920000915 polyvinyl chloride Polymers 0.000 abstract 1
239000004800 polyvinyl chloride Substances 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
SBHRWOBHKASWGU-UHFFFAOYSA-M tridodecyl(methyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(CCCCCCCCCCCC)CCCCCCCCCCCC SBHRWOBHKASWGU-UHFFFAOYSA-M 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
- G01N27/3335—Ion-selective electrodes or membranes the membrane containing at least one organic component
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/817—Enzyme or microbe electrode

DE69330187T 1992-03-10 1993-03-10 Verwendung einer ionen-selektiven polymermembran zur bestimmung von heparin Expired - Fee Related DE69330187T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/849,218 US5236570A (en)	1992-03-10	1992-03-10	Heparin-selective polymeric membrane electrode
PCT/US1993/002149 WO1993018396A1 (en)	1992-03-10	1993-03-10	Heparin-selective polymeric membrane electrode

Publications (2)

Publication Number	Publication Date
DE69330187D1 true DE69330187D1 (de)	2001-06-07
DE69330187T2 DE69330187T2 (de)	2002-01-31

Family

ID=25305334

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69330187T Expired - Fee Related DE69330187T2 (de)	1992-03-10	1993-03-10	Verwendung einer ionen-selektiven polymermembran zur bestimmung von heparin

Country Status (7)

Country	Link
US (1)	US5236570A (de)
EP (1)	EP0630472B1 (de)
JP (1)	JP3390439B2 (de)
AT (1)	ATE200930T1 (de)
CA (1)	CA2117692C (de)
DE (1)	DE69330187T2 (de)
WO (1)	WO1993018396A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5607567A (en) *	1992-03-10	1997-03-04	The Board Of Regents Acting For And On Behalf Of University Of Michigan	Protamine-responsive polymeric membrane electrode
US5453171A (en) *	1992-03-10	1995-09-26	The Board Of Regents Of The University Of Michigan	Heparin-selective polymeric membrane electrode
US5415746A (en) *	1992-12-21	1995-05-16	E. I. Du Pont De Nemours And Company	Potentiometric ion determinations using enhanced selectivity asymmetric ion-selective membrane
US5611900A (en) *	1995-07-20	1997-03-18	Michigan State University	Microbiosensor used in-situ
US5755939A (en) *	1996-04-30	1998-05-26	Medtronic, Inc.	Polyion sensor with molecular weight differentiation
US5807471A (en) *	1996-04-30	1998-09-15	Medtronic, Inc.	Sensor for detecting low concentrations of polyions
EP1287345A2 (de) *	2000-05-18	2003-03-05	Medtronic, Inc.	Ionenspezifische festkörperelektrode mit einer polymerischen membran
WO2002046731A2 (en) *	2000-12-08	2002-06-13	The Regents Of The University Of Michigan	Rotating potentiometric electrode
KR100444325B1 (ko) *	2001-07-16	2004-08-16	한국과학기술연구원	안정성이 향상된 은염이 함유된 올레핀 촉진수송 고분자 분리막 및 이의 제조방법
US7569393B2 (en) *	2002-06-28	2009-08-04	International Technidyne Corporation	Analytical test cartridge; and, methods
WO2005008232A1 (en) *	2003-07-09	2005-01-27	Auburn University	Reversible electrochemical sensors for polyions
US20050238536A1 (en) *	2004-04-21	2005-10-27	Striepeke Steven K	Device and method for measuring glycosaminoglycans in body fluids
EP1747451B1 (de) *	2004-05-17	2011-11-02	Medtronic, Inc.	Point-of-care-heparinbestimmungssystem
US9561309B2 (en)	2004-05-27	2017-02-07	Advanced Cardiovascular Systems, Inc.	Antifouling heparin coatings
US7563780B1 (en)	2004-06-18	2009-07-21	Advanced Cardiovascular Systems, Inc.	Heparin prodrugs and drug delivery stents formed therefrom
US20070212786A1 (en) *	2005-09-29	2007-09-13	Scott Manalis	Monitoring heparin by microelectronic devices
US7763271B1 (en)	2006-08-11	2010-07-27	Abbott Cardiovascular Systems Inc.	Polymeric micelle-based local delivery methods and devices
US8048442B1 (en)	2008-09-16	2011-11-01	Abbott Cardiovascular Systems Inc.	Modified heparin-based coatings and related drug eluting stents
WO2014113460A1 (en) *	2013-01-15	2014-07-24	Ndsu Research Foundation	Biodegradable soil sensor, system and method
US9562885B2 (en)	2013-05-17	2017-02-07	Umm Al-Qura University	Ionophore and polymer membrane selective for aluminum (III) ion
WO2016040067A1 (en)	2014-09-09	2016-03-17	University Of Delaware	Perchlorate ion permselective membranes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4214968A (en) *	1978-04-05	1980-07-29	Eastman Kodak Company	Ion-selective electrode
US4440218A (en) *	1981-05-11	1984-04-03	Completion Services, Inc.	Slurry up particulate placement tool
US4810351A (en) *	1986-09-18	1989-03-07	Technicon Instruments Corporation	Carbonate selective membrane and electrode
JPH01100449A (ja) *	1987-10-13	1989-04-18	Agency Of Ind Science & Technol	電極膜
DE4003194A1 (de) *	1990-02-03	1991-08-08	Boehringer Mannheim Gmbh	Verfahren und sensorelektrodensystem zur elektrochemischen bestimmung eines analyts oder einer oxidoreduktase sowie verwendung hierfuer geeigneter verbindungen

1992
- 1992-03-10 US US07/849,218 patent/US5236570A/en not_active Expired - Lifetime
1993
- 1993-03-10 CA CA002117692A patent/CA2117692C/en not_active Expired - Fee Related
- 1993-03-10 AT AT93907373T patent/ATE200930T1/de not_active IP Right Cessation
- 1993-03-10 WO PCT/US1993/002149 patent/WO1993018396A1/en active IP Right Grant
- 1993-03-10 EP EP93907373A patent/EP0630472B1/de not_active Expired - Lifetime
- 1993-03-10 DE DE69330187T patent/DE69330187T2/de not_active Expired - Fee Related
- 1993-03-10 JP JP51597693A patent/JP3390439B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO1993018396A1 (en)	1993-09-16
US5236570A (en)	1993-08-17
JPH07507137A (ja)	1995-08-03
CA2117692A1 (en)	1993-09-16
JP3390439B2 (ja)	2003-03-24
DE69330187T2 (de)	2002-01-31
EP0630472A4 (de)	1995-08-23
ATE200930T1 (de)	2001-05-15
CA2117692C (en)	2004-11-23
EP0630472B1 (de)	2001-05-02
EP0630472A1 (de)	1994-12-28

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Legal Events

Date	Code	Title	Description
2008-03-20	8364	No opposition during term of opposition
2009-01-22	8339	Ceased/non-payment of the annual fee