DE69331421D1 - N-substituierte Hydroxyethylaminosulfamidsäure-Derivate verwendbar als Inhibitoren retroviraler Proteasen - Google Patents
N-substituierte Hydroxyethylaminosulfamidsäure-Derivate verwendbar als Inhibitoren retroviraler ProteasenInfo
- Publication number
- DE69331421D1 DE69331421D1 DE69331421T DE69331421T DE69331421D1 DE 69331421 D1 DE69331421 D1 DE 69331421D1 DE 69331421 T DE69331421 T DE 69331421T DE 69331421 T DE69331421 T DE 69331421T DE 69331421 D1 DE69331421 D1 DE 69331421D1
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- acid derivatives
- inhibitors
- hydroxyethylaminosulfamic
- retroviral proteases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/04—Diamides of sulfuric acids
- C07C307/06—Diamides of sulfuric acids having nitrogen atoms of the sulfamide groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96873092A | 1992-10-30 | 1992-10-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69331421D1 true DE69331421D1 (de) | 2002-02-07 |
DE69331421T2 DE69331421T2 (de) | 2002-08-01 |
Family
ID=25514685
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69319351T Expired - Fee Related DE69319351T2 (de) | 1992-10-30 | 1993-10-29 | Hydroxyethylaminosulfamidsäure-derivate verwendbar als inhibitoren retroviraler proteasen |
DE69331421T Expired - Fee Related DE69331421T2 (de) | 1992-10-30 | 1993-10-29 | N-substituierte Hydroxyethylaminosulfamidsäure-Derivate verwendbar als Inhibitoren retroviraler Proteasen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69319351T Expired - Fee Related DE69319351T2 (de) | 1992-10-30 | 1993-10-29 | Hydroxyethylaminosulfamidsäure-derivate verwendbar als inhibitoren retroviraler proteasen |
Country Status (10)
Country | Link |
---|---|
US (4) | US6156768A (de) |
EP (2) | EP0666842B1 (de) |
AT (2) | ATE167669T1 (de) |
AU (1) | AU5547094A (de) |
CA (1) | CA2142997A1 (de) |
DE (2) | DE69319351T2 (de) |
DK (2) | DK0810208T3 (de) |
ES (2) | ES2118364T3 (de) |
PT (1) | PT810208E (de) |
WO (1) | WO1994010134A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
US5783701A (en) | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
ATE167669T1 (de) | 1992-10-30 | 1998-07-15 | Searle & Co | Hydroxyethylaminosulfamidsäure-derivate verwendbar als inhibitoren retroviraler proteasen |
CN1146201A (zh) * | 1994-03-07 | 1997-03-26 | 沃泰克斯药物股份有限公司 | 用作天冬氨酰蛋白酶抑制剂的磺胺衍生物 |
US5756533A (en) * | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6143788A (en) * | 1995-03-10 | 2000-11-07 | G.D. Searle & Co. | Bis-amino acid hydroxyethlamino sulfonamide retroviral protease inhibitors |
EP1188766A1 (de) | 1995-03-10 | 2002-03-20 | G.D. Searle & Co. | Verbindungen der Struktur bis-Aminosäure-Hydroxyethylamino-Sulfonamid als Inhibitoren der retroviralen Protease |
US5776971A (en) | 1995-03-10 | 1998-07-07 | G.D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
NZ306027A (en) | 1995-03-10 | 1999-03-29 | Searle & Co | Heterocyclecarbonyl amino acid hydroxyethylamin sulfonamide derivatives, preparation and use as retroviral protease inhibitors |
US6407134B1 (en) | 1995-03-10 | 2002-06-18 | G. D. Searle & Co. | Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6150556A (en) * | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US6861539B1 (en) | 1995-03-10 | 2005-03-01 | G. D. Searle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US7339078B2 (en) | 1995-03-10 | 2008-03-04 | G.D. Searle Llc | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
US6004957A (en) * | 1995-06-07 | 1999-12-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
EP0861085B1 (de) | 1995-11-13 | 2005-07-20 | Vitaleech Bioscience N.V. | Antivirale isolate von blutegeln |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
AP1717A (en) | 1998-06-19 | 2007-01-30 | Vertex Pharma | Sulfonamide inhibitors of aspartyl protease. |
US6495358B1 (en) * | 2000-04-19 | 2002-12-17 | Wichita State University | Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes |
US20060128634A1 (en) * | 2002-11-14 | 2006-06-15 | Carini David J | Alpha, alpha-disubstituted benzylglycine derivatives as HIV protease inhibitors |
US6943170B2 (en) * | 2002-11-14 | 2005-09-13 | Bristol-Myers Squibb Company | N-cycloalkylglycines as HIV protease inhibitors |
US7820511B2 (en) * | 2004-07-08 | 2010-10-26 | Semisouth Laboratories, Inc. | Normally-off integrated JFET power switches in wide bandgap semiconductors and methods of making |
CA2983162A1 (en) * | 2015-04-23 | 2016-10-27 | VIIV Healthcare UK (No.5) Limited | Inhibitors of human immunodeficiency virus replication |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5142056A (en) * | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
EP0068378B1 (de) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Imidazo(1,2-a)pyridine und -pyrazine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
DE3377497D1 (en) * | 1982-09-15 | 1988-09-01 | Haessle Ab | Enzyme inhibitors |
US4668770A (en) * | 1982-12-27 | 1987-05-26 | Merck & Co., Inc. | Renin inhibitory tripeptides |
DE3381565D1 (de) * | 1982-12-27 | 1990-06-21 | Merck & Co Inc | Reninhemmende tripeptide. |
AU573735B2 (en) * | 1983-02-07 | 1988-06-23 | Aktiebolaget Hassle | Peptide analogue enzyme inhibitors |
JPS59227851A (ja) * | 1983-06-09 | 1984-12-21 | Sankyo Co Ltd | レニン阻害作用を有するペプチド類 |
US4514391A (en) * | 1983-07-21 | 1985-04-30 | E. R. Squibb & Sons, Inc. | Hydroxy substituted peptide compounds |
US4477441A (en) * | 1983-09-14 | 1984-10-16 | Merck & Co., Inc. | Renin inhibitors containing a C-terminal disulfide cycle |
US4645759A (en) * | 1984-06-22 | 1987-02-24 | Abbott Laboratories | Renin inhibiting compounds |
US4616088A (en) * | 1984-10-29 | 1986-10-07 | E. R. Squibb & Sons, Inc. | Amino acid ester and amide renin inhibitor |
US4668769A (en) * | 1985-08-02 | 1987-05-26 | Hoover Dennis J | Oxa- and azahomocyclostatine polypeptides |
US4599198A (en) * | 1985-08-02 | 1986-07-08 | Pfizer Inc. | Intermediates in polypeptide synthesis |
CA1282549C (en) * | 1985-11-12 | 1991-04-02 | Eric M. Gordon | Aminocarbonyl renin inhibitors |
US4757050A (en) * | 1985-12-23 | 1988-07-12 | E. R. Squibb Sons, Inc. | Ureido renin inhibitors |
CA1297631C (en) * | 1985-12-23 | 1992-03-17 | Sesha I. Natarajan | Ureido renin inhibitors |
US4880938A (en) * | 1986-06-16 | 1989-11-14 | Merck & Co., Inc. | Amino acid analogs |
DE3635907A1 (de) * | 1986-10-22 | 1988-04-28 | Merck Patent Gmbh | Hydroxy-aminosaeurederivate |
NL8800100A (nl) * | 1987-01-21 | 1988-08-16 | Sandoz Ag | Nieuwe peptidederivaten en werkwijzen voor het bereiden en toepassen van deze derivaten. |
USH725H (en) * | 1987-02-26 | 1990-01-02 | E. R. Squibb & Sons, Inc. | Ureido amino and imino acids, compositions and methods for use |
GB8707412D0 (en) * | 1987-03-27 | 1987-04-29 | Fujisawa Pharmaceutical Co | Peptide compounds |
DE3830825A1 (de) * | 1987-09-15 | 1989-03-23 | Sandoz Ag | Hydrophile reninhemmer, ihre herstellung und verwendung |
IL89900A0 (en) * | 1988-04-12 | 1989-12-15 | Merck & Co Inc | Hiv protease inhibitors useful for the treatment of aids and pharmaceutical compositions containing them |
US4977277A (en) * | 1988-05-09 | 1990-12-11 | Abbott Laboratories | Functionalized peptidyl aminodiols and -triols 4-amino-5-cyclohexyl-3-hydroxy-1,2-oxopentane and derivatives thereof |
IL90218A0 (en) * | 1988-05-13 | 1989-12-15 | Abbott Lab | Retroviral protease inhibitors |
CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
IL91307A0 (en) * | 1988-08-24 | 1990-03-19 | Merck & Co Inc | Hiv protease inhibitors and pharmaceutical compositions for the treatment of aids containing them |
IL91780A (en) * | 1988-10-04 | 1995-08-31 | Abbott Lab | History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them |
CA2012306A1 (en) * | 1989-03-28 | 1990-09-28 | Werner Neidhart | Amino acid derivatives |
DE3912829A1 (de) * | 1989-04-19 | 1990-10-25 | Bayer Ag | Verwendung von renininhibitorischen peptiden als mittel gegen retroviren |
TW225540B (de) * | 1990-06-28 | 1994-06-21 | Shionogi & Co | |
CA2086414A1 (en) | 1990-07-06 | 1992-01-07 | Geoffrey B. Dreyer | Retroviral protease inhibitors |
JPH06503092A (ja) * | 1990-11-19 | 1994-04-07 | モンサント カンパニー | レトロウイルスプロテアーゼ阻害剤 |
IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
US5783701A (en) * | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
ATE167669T1 (de) | 1992-10-30 | 1998-07-15 | Searle & Co | Hydroxyethylaminosulfamidsäure-derivate verwendbar als inhibitoren retroviraler proteasen |
IL104283A (en) * | 1992-12-30 | 1996-12-05 | Agis Ind 1983 Ltd | Non-emulsion antiviral topical pharmaceutical composition comprising acyclovir an aqueous gel agent and an alkali oleate |
-
1993
- 1993-10-29 AT AT94900506T patent/ATE167669T1/de not_active IP Right Cessation
- 1993-10-29 EP EP94900506A patent/EP0666842B1/de not_active Expired - Lifetime
- 1993-10-29 DE DE69319351T patent/DE69319351T2/de not_active Expired - Fee Related
- 1993-10-29 DK DK97113206T patent/DK0810208T3/da active
- 1993-10-29 CA CA002142997A patent/CA2142997A1/en not_active Abandoned
- 1993-10-29 ES ES94900506T patent/ES2118364T3/es not_active Expired - Lifetime
- 1993-10-29 AT AT97113206T patent/ATE211462T1/de not_active IP Right Cessation
- 1993-10-29 ES ES97113206T patent/ES2170305T3/es not_active Expired - Lifetime
- 1993-10-29 EP EP97113206A patent/EP0810208B1/de not_active Expired - Lifetime
- 1993-10-29 WO PCT/US1993/010552 patent/WO1994010134A1/en active IP Right Grant
- 1993-10-29 AU AU55470/94A patent/AU5547094A/en not_active Abandoned
- 1993-10-29 DE DE69331421T patent/DE69331421T2/de not_active Expired - Fee Related
- 1993-10-29 US US08/379,545 patent/US6156768A/en not_active Expired - Fee Related
- 1993-10-29 DK DK94900506T patent/DK0666842T3/da active
- 1993-10-29 PT PT97113206T patent/PT810208E/pt unknown
-
2000
- 2000-08-04 US US09/633,063 patent/US6444678B1/en not_active Expired - Fee Related
-
2002
- 2002-06-25 US US10/178,956 patent/US7037941B2/en not_active Expired - Fee Related
-
2005
- 2005-06-28 US US11/167,164 patent/US7202258B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7037941B2 (en) | 2006-05-02 |
US7202258B2 (en) | 2007-04-10 |
WO1994010134A1 (en) | 1994-05-11 |
DE69319351T2 (de) | 1998-11-19 |
EP0810208A2 (de) | 1997-12-03 |
US20030158236A1 (en) | 2003-08-21 |
EP0810208B1 (de) | 2002-01-02 |
ATE211462T1 (de) | 2002-01-15 |
US6156768A (en) | 2000-12-05 |
ES2170305T3 (es) | 2002-08-01 |
DE69331421T2 (de) | 2002-08-01 |
PT810208E (pt) | 2002-06-28 |
DK0810208T3 (da) | 2002-03-18 |
ATE167669T1 (de) | 1998-07-15 |
DE69319351D1 (de) | 1998-07-30 |
EP0666842B1 (de) | 1998-06-24 |
ES2118364T3 (es) | 1998-09-16 |
AU5547094A (en) | 1994-05-24 |
US20050267214A1 (en) | 2005-12-01 |
CA2142997A1 (en) | 1994-05-11 |
EP0666842A1 (de) | 1995-08-16 |
EP0810208A3 (de) | 1998-12-02 |
DK0666842T3 (da) | 1998-11-02 |
US6444678B1 (en) | 2002-09-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |