DE69331805T2 - Glycolipid enzym-polymer konjugate - Google Patents

Glycolipid enzym-polymer konjugate

Info

Publication number
DE69331805T2
DE69331805T2 DE69331805T DE69331805T DE69331805T2 DE 69331805 T2 DE69331805 T2 DE 69331805T2 DE 69331805 T DE69331805 T DE 69331805T DE 69331805 T DE69331805 T DE 69331805T DE 69331805 T2 DE69331805 T2 DE 69331805T2
Authority
DE
Germany
Prior art keywords
polymer conjugates
glycolipid
enzyme
glycolipid enzyme
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69331805T
Other languages
English (en)
Other versions
DE69331805D1 (de
Inventor
Robert G L Shorr
Myung-Ok Cho
Carl W Gilbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Publication of DE69331805D1 publication Critical patent/DE69331805D1/de
Application granted granted Critical
Publication of DE69331805T2 publication Critical patent/DE69331805T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69331805T 1992-12-10 1993-12-08 Glycolipid enzym-polymer konjugate Expired - Fee Related DE69331805T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98980292A 1992-12-10 1992-12-10
PCT/US1993/011920 WO1994013311A1 (en) 1992-12-10 1993-12-08 Glycolipid enzyme-polymer conjugates

Publications (2)

Publication Number Publication Date
DE69331805D1 DE69331805D1 (de) 2002-05-16
DE69331805T2 true DE69331805T2 (de) 2002-11-28

Family

ID=25535471

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69331805T Expired - Fee Related DE69331805T2 (de) 1992-12-10 1993-12-08 Glycolipid enzym-polymer konjugate

Country Status (8)

Country Link
US (2) US5620884A (de)
EP (1) EP0675727B1 (de)
JP (1) JPH08507677A (de)
AU (1) AU5743994A (de)
CA (1) CA2150956A1 (de)
DE (1) DE69331805T2 (de)
DK (1) DK0675727T3 (de)
WO (1) WO1994013311A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2175578A1 (en) * 1993-11-03 1995-05-11 Alec Sehon Cell control and suppression
AU3275595A (en) * 1994-08-05 1996-03-04 Molecular/Structural Biotechnologies, Inc. Site-specific biomolecular complexes
CA2229435A1 (en) * 1995-09-14 1997-03-20 Lxr Biotechnology Inc. Compositions with anti-apoptotic activity, containing a mixture of phospholipids
SE9601817D0 (sv) 1996-05-13 1996-05-13 Karsten Buschard Novel glycolipid complexex and their uses
ATE322900T1 (de) * 1996-07-15 2006-04-15 Macrozyme Dnm B V Deoxynojirimycin derivate und ihre verwendung als glukosesylceramidase-inhibitoren
AU4648697A (en) 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
WO1998021302A1 (en) * 1996-11-14 1998-05-22 Polymer Technology Corporation Use of water soluble enzyme-polymer conjugates for cleaning contact lenses
AU6326198A (en) 1997-02-13 1998-09-08 Lxr Biotechnology Inc. Organ preservation solution
US6251866B1 (en) 1997-08-05 2001-06-26 Watson Laboratories, Inc. Conjugates targeted to the interleukin-2 receptor
US6638526B1 (en) 1998-06-23 2003-10-28 Novozymes A/S Polypeptides conjugated to copolymers of ethylene oxide and propylene oxide to reduce allergenicity
EP1088059B1 (de) * 1998-06-23 2004-09-15 Novozymes A/S Polypeptid-polymer konjugat
AU770911B2 (en) * 1998-07-17 2004-03-04 Novozymes A/S A polypeptide-polymer conjugate with improved wash performance
AU6050600A (en) * 1999-07-26 2001-02-13 G.D. Searle & Co. Use of long-chain n-alkyl derivates of deoxynojirimycin and a glucocerebrosidaseenzyme for the manufacture of medicament for the treatment of glycolipid storag e diseases
WO2001049830A2 (en) * 1999-12-30 2001-07-12 Maxygen Aps Improved lysosomal enzymes and lysosomal enzyme activators
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
WO2003017938A2 (en) * 2001-08-22 2003-03-06 Watson Pharmaceuticals, Inc. Conjugates targeted to target receptors
US6887952B1 (en) * 2004-02-12 2005-05-03 Biosite, Inc. N-aryl-carbamic acid ester-derived and valeric acid ester-derived cross-linkers and conjugates, and methods for their synthesis and use
US7740861B2 (en) * 2004-06-16 2010-06-22 University Of Massachusetts Drug delivery product and methods
CA2579370A1 (en) * 2004-09-09 2006-03-23 Biosite Incorporated Methods and compositions for measuring canine bnp and uses thereof
JP5302537B2 (ja) 2004-09-17 2013-10-02 ユニバーシティ オブ マサチューセッツ リソソーム酵素欠損症のための組成物およびそれらの使用
US7879979B2 (en) * 2005-01-21 2011-02-01 Alere International Arginine analogs, and methods for their synthesis and use
US9707252B2 (en) 2005-02-09 2017-07-18 Covidien Lp Synthetic sealants
WO2007050643A2 (en) * 2005-10-24 2007-05-03 University Of Massachusetts Compositions and their uses for gene therapy of bone conditions
EP1986612B1 (de) * 2006-02-07 2012-09-12 Shire Human Genetic Therapies, Inc. Stabilisierte Zubereitung enthaltend Glucocerebrosidase
WO2007097934A2 (en) * 2006-02-17 2007-08-30 Elusys Therapeutics, Inc. Methods and compositions for using erythrocytes as carriers for delivery of drugs
WO2009058913A2 (en) * 2007-10-29 2009-05-07 University Of Massachusetts Encapsulated nanoparticles for nucleic acid delivery
WO2010080720A2 (en) * 2009-01-12 2010-07-15 Nektar Therapeutics Conjugates of a lysosomal enzyme moiety and a water soluble polymer
US8765171B2 (en) * 2009-03-09 2014-07-01 The Regents Of The University Of California Methods and compositions for liposomal formulation of antigens and uses thereof
NZ713967A (en) * 2009-07-28 2017-01-27 Shire Human Genetic Therapies Compositions and methods for treating gaucher disease
US9194011B2 (en) 2009-11-17 2015-11-24 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
EP2542572B1 (de) * 2010-03-02 2015-05-06 Protalix Ltd. Multimere formen von therapeutischen proteinen und ihre verwendung
AU2013225816B2 (en) 2012-03-02 2017-10-26 Takeda Pharmaceutical Company Limited Compositions and methods for treating Type III Gaucher Disease
US9694069B2 (en) 2013-03-14 2017-07-04 Alere San Diego, Inc. 6-acetylmorphine analogs, and methods for their synthesis and use
US10980892B2 (en) 2015-06-15 2021-04-20 Angiochem Inc. Methods for the treatment of leptomeningeal carcinomatosis
AU2017267728B2 (en) 2016-05-18 2021-11-04 Alere San Diego, Inc. 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use
CA3066915A1 (en) 2017-06-11 2018-12-20 Molecular Express, Inc. Methods and compositions for substance use disorder vaccine formulations and uses thereof
KR20230017207A (ko) 2020-04-30 2023-02-03 사이로파 비.브이. 항-cd103 항체

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3910822A (en) * 1974-03-14 1975-10-07 Us Health Isolation of glucocerebrosidase from human placental tissue
US4749570A (en) * 1981-12-31 1988-06-07 The Governors Of The University Of Alberta Targeting conjugates of albumin and therapeutic agents
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
JPS61275978A (ja) * 1985-05-31 1986-12-06 Toshiba Corp 演算処理装置
AU2946289A (en) * 1987-12-23 1989-07-19 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cloned dna for synthesizing unique glucocerebrosidase
EP0401362B1 (de) * 1988-12-23 1996-05-29 Genzyme Corporation Cho-zellen befähigt enzymatisch aktive rekombinante-glukocerebrosidase zu produzieren
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
DE69213714T2 (de) * 1991-01-21 1997-01-23 Genzyme Corp Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen

Also Published As

Publication number Publication date
EP0675727A1 (de) 1995-10-11
EP0675727A4 (de) 1997-01-08
AU5743994A (en) 1994-07-04
US5620884A (en) 1997-04-15
JPH08507677A (ja) 1996-08-20
DE69331805D1 (de) 2002-05-16
CA2150956A1 (en) 1994-06-23
DK0675727T3 (da) 2002-08-05
EP0675727B1 (de) 2002-04-10
WO1994013311A1 (en) 1994-06-23
US5705153A (en) 1998-01-06

Similar Documents

Publication Publication Date Title
DE69331805D1 (de) Glycolipid enzym-polymer konjugate
DK0385610T3 (da) Konjugater
BR9307260A (pt) Sulfonilaminocarboniltriazolinonas
DE69305413T2 (de) Pulverisierungsvorrichtung
ATA255692A (de) Sportschuh
ATA236892A (de) Rotornut
FI925982A0 (fi) Patientlyftare
NO933592D0 (no) Alkoksymetylsubstituerte pyridinbifenyler
NO931514L (no) Polyetere
ATA227792A (de) Sportschuh
KR940009121U (ko) 브래지어
KR930022628U (ko) 파종기
BR9303821A (pt) Estrutura de acoplamento
DE69123256T2 (de) Antigen-antikörperkonjugaten
DE9218271U1 (de) Sämaschine
NZ238953A (en) Antibody-superantigen conjugates
BR7202161U (pt) Arado
BR9204442A (pt) Desintegrador aperfeiçoado
KR940014188U (ko) 투 망
DE69331266T2 (de) Oligonucleotid-polyamide konjugate
DK110787D0 (da) Konjugater
SE9200226D0 (sv) Tvaa traeslag
SE9202239D0 (sv) Emanuelle ii
BR9202399A (pt) Jifo ii
DE9313705U1 (de) Refraktometer

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee