DE69333080D1 - Fibrindichtungsmittelzusammensetzungen und Verfahren zu deren Verwendung - Google Patents

Fibrindichtungsmittelzusammensetzungen und Verfahren zu deren Verwendung

Info

Publication number
DE69333080D1
DE69333080D1 DE69333080T DE69333080T DE69333080D1 DE 69333080 D1 DE69333080 D1 DE 69333080D1 DE 69333080 T DE69333080 T DE 69333080T DE 69333080 T DE69333080 T DE 69333080T DE 69333080 D1 DE69333080 D1 DE 69333080D1
Authority
DE
Germany
Prior art keywords
methods
fibrin
fibrin sealant
sealant compositions
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333080T
Other languages
English (en)
Other versions
DE69333080T2 (de
Inventor
Peter Andrew David Edwardson
John Esam Fairbrother
Ronald Stephen Gardner
Derek Andrew Hollingsbee
Stuart Anth Cederholm-Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
VIVOLUTION A/S, BIRKEROD, DK
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of DE69333080D1 publication Critical patent/DE69333080D1/de
Application granted granted Critical
Publication of DE69333080T2 publication Critical patent/DE69333080T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/06—Enzymes or microbial cells immobilised on or in an organic carrier attached to the carrier via a bridging agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
DE69333080T 1992-10-08 1993-10-08 Fibrindichtungsmittelzusammensetzungen und Verfahren zu deren Verwendung Expired - Lifetime DE69333080T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95821292A 1992-10-08 1992-10-08
US958212 1992-10-08

Publications (2)

Publication Number Publication Date
DE69333080D1 true DE69333080D1 (de) 2003-08-14
DE69333080T2 DE69333080T2 (de) 2004-04-15

Family

ID=25500729

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333080T Expired - Lifetime DE69333080T2 (de) 1992-10-08 1993-10-08 Fibrindichtungsmittelzusammensetzungen und Verfahren zu deren Verwendung

Country Status (24)

Country Link
US (12) US5750657A (de)
EP (2) EP1266666A3 (de)
JP (1) JP3771284B2 (de)
KR (1) KR940008697A (de)
CN (1) CN1091315A (de)
AT (1) ATE244581T1 (de)
AU (1) AU676201B2 (de)
BR (1) BR9304185A (de)
CA (3) CA2566574A1 (de)
CZ (1) CZ211793A3 (de)
DE (1) DE69333080T2 (de)
DK (1) DK0592242T3 (de)
ES (2) ES2202306T3 (de)
FI (1) FI110616B (de)
HU (1) HU218898B (de)
IL (1) IL107211A (de)
MX (1) MX9306272A (de)
NO (1) NO314412B1 (de)
NZ (3) NZ280264A (de)
PL (3) PL173858B1 (de)
PT (1) PT592242E (de)
RU (1) RU2143924C1 (de)
SG (1) SG49640A1 (de)
SK (1) SK109393A3 (de)

Families Citing this family (251)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196054B1 (en) * 1990-11-27 2007-03-27 The American National Red Cross Methods for treating wound tissue and forming a supplemented fibrin matrix
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
CN1091315A (zh) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US8795332B2 (en) 2002-09-30 2014-08-05 Ethicon, Inc. Barbed sutures
ZA948564B (en) * 1993-11-19 1995-07-26 Bristol Myers Squibb Co Liquid separation apparatus and method
CA2188647A1 (en) * 1994-05-02 1995-11-09 Stewart Anthony Cederholm-Williams Recombinant fibrin chains, fibrin and fibrin-homologs
US5830352A (en) * 1994-12-02 1998-11-03 Bristol-Myers Squibb Company Centrifuge reagent delivery system
US5733446A (en) * 1994-12-02 1998-03-31 Bristol-Myers Squibb Company Centrifuge with annular filter
US6946079B1 (en) * 1994-12-02 2005-09-20 Bristol-Myers Squibb Company Centrifugal filtration method for separating fibrin monomer from blood
CZ164797A3 (cs) * 1994-12-02 1998-07-15 Bristol-Myers Sguibb Company Způsob oddělování fibrinu I z krevní plazmy a zařízení k tomu
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US5605541A (en) * 1994-12-07 1997-02-25 E. R. Squibb And Sons, Inc. Fibrin sealant applicatoor
US6074663A (en) * 1995-01-16 2000-06-13 Baxter International Inc. Method of using cross-linked fibrin material
US5733545A (en) * 1995-03-03 1998-03-31 Quantic Biomedical Partners Platelet glue wound sealant
US5691152A (en) * 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
US6551794B1 (en) 1995-11-09 2003-04-22 E. R. Squibb & Sons, Inc. Stable biotinylated biomolecule composition
CN1207688A (zh) 1995-12-07 1999-02-10 布里斯托尔-迈尔斯斯奎布公司 施加两种液体组份的混合物的方法
WO1997040864A1 (en) * 1996-04-30 1997-11-06 Medtronic, Inc. Method for making autologous fibrin sealant
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
AU3720097A (en) 1996-07-12 1998-02-09 Baxter International Inc. A fibrin delivery device and method for forming fibrin on a surface
DE19634313A1 (de) * 1996-08-24 1998-02-26 Behringwerke Ag Methode zur Stabilisierung von Plättchen
US5844087A (en) * 1996-11-05 1998-12-01 Bayer Corporation Method and device for delivering fibrin glue
NZ335751A (en) 1996-11-15 2001-01-26 Bristol Myers Squibb Co Devices and methods for applying a mixture of two or more liquid components to form a biomaterial
US6613020B1 (en) 1996-12-06 2003-09-02 Bristol-Myers Squibb Company Method of applying a mixture of two liquid components as well as a device for carrying out the method
FR2757770B1 (fr) * 1996-12-30 1999-02-26 Inoteb Procede de preparation d'une colle biologique capable de coaguler par simple addition d'ions calcium
WO1998030331A1 (en) * 1997-01-08 1998-07-16 Bristol-Myers Squibb Company Centrifuge apparatus for separating blood
IL130729A0 (en) * 1997-01-08 2000-06-01 Bristol Myers Squibb Co Apparatus and methods for preparing blood or plasma component solutions of known concentration
US6132598A (en) * 1997-01-08 2000-10-17 Bristol-Myers Squibb Company Centrifuge apparatus with temperature control means
EP1011465A4 (de) * 1997-03-27 2006-10-04 Bristol Myers Squibb Co Laparoskopischer applikator für dichtmittel
US5971956A (en) * 1997-04-15 1999-10-26 Biosurgical Corporation Medical suctioning apparatus and methods of use
US6331172B1 (en) 1997-04-14 2001-12-18 Baxter International Inc. Applicator for dispensing measured quantities with use of controlled suction
US5931855A (en) 1997-05-21 1999-08-03 Frank Hoffman Surgical methods using one-way suture
GB9711927D0 (en) * 1997-06-09 1997-08-06 Bristol Myers Squibb Co Compositions useful as fibrin sealants
IT1292410B1 (it) * 1997-06-24 1999-02-08 Roberto Beretta Contenitore di pronto impiego per ottenere colla di fibrina autologa
US6979307B2 (en) 1997-06-24 2005-12-27 Cascade Medical Enterprises Llc Systems and methods for preparing autologous fibrin glue
US7745106B2 (en) 1997-06-24 2010-06-29 Cascade Medical Enterprises, Llc Methods and devices for separating liquid components
ZA987019B (en) * 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
AT407484B (de) * 1997-11-12 2001-03-26 Bio Prod & Bio Eng Ag Arzneimittel zur förderung der wundheilung
JP2001526027A (ja) * 1997-12-09 2001-12-18 ブリストル−マイヤーズ スクイブ カンパニー フィブリノーゲン変換酵素ハイブリド
EP1037659A4 (de) * 1997-12-09 2005-02-09 Bristol Myers Squibb Co Fibrinolytischer inhibitor für dichtungsmittel
US6159232A (en) 1997-12-16 2000-12-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6478808B2 (en) * 1997-12-17 2002-11-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6762336B1 (en) 1998-01-19 2004-07-13 The American National Red Cross Hemostatic sandwich bandage
US6540716B1 (en) * 1998-05-06 2003-04-01 Bristol-Myers Squibb Company Directional endoscopic delivery of material
US20020022588A1 (en) * 1998-06-23 2002-02-21 James Wilkie Methods and compositions for sealing tissue leaks
US6083383A (en) * 1998-06-25 2000-07-04 Huang; Xun Yang Apparatus for production of fibrin ogen or fibrin glue
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
JP2000070241A (ja) * 1998-08-31 2000-03-07 Nissho Corp 急速凝固用真空採血管
BE1012536A3 (fr) 1998-11-04 2000-12-05 Baxter Int Element muni d'une couche de fibrine sa preparation et son utilisation.
CN1335757A (zh) 1998-11-12 2002-02-13 聚合体生物科学公司 可用于快速凝血和止血的止血聚合物
DE10025001A1 (de) * 2000-05-22 2001-11-29 Aventis Behring Gmbh Gewebekleber mit verbesserten anti-adhäsiven Eigenschaften
WO2000029041A1 (de) * 1998-11-18 2000-05-25 Aventis Behring Gmbh Stabilisierte proteinzubereitungen für einen gewebekleber
DE19853033A1 (de) * 1998-11-18 2000-05-25 Centeon Pharma Gmbh Stabilisierte Proteinzubereitung für einen Gewebekleber
US7276235B2 (en) * 1998-11-18 2007-10-02 Zlb Behring Gmbh Tissue glue with improved antiadhesive properties
EP1143983B1 (de) * 1998-12-02 2006-03-01 Bristol-Myers Squibb Company Spray verabreichung von zellen
DE19858463A1 (de) * 1998-12-18 2000-06-21 Centeon Pharma Gmbh Verwendung eines Fibrinklebers zur Regeneration des Lebergewebes
US6310036B1 (en) 1999-01-09 2001-10-30 Last Chance Tissue Adhesives Corporation High strength, Bio-compatible tissue adhesive and methods for treating vigorously bleeding surfaces
US7015198B1 (en) * 1999-05-11 2006-03-21 Orentreich Foundation For The Advancement Of Science, Inc. Materials for soft tissue augmentation and methods of making and using same
US6921412B1 (en) 1999-05-18 2005-07-26 Cryolife, Inc. Self-supporting, shaped, three-dimensional biopolymeric materials and methods
AT500670A1 (de) * 1999-05-19 2006-02-15 Bio & Bio Licensing Sa Arzneimittel zur lokalen anwendung
JP2003500172A (ja) * 1999-06-01 2003-01-07 ブリストル−マイヤーズ スクイブ カンパニー フィブリンポリマー構造体
NZ515581A (en) * 1999-06-01 2004-01-30 Bristol Myers Squibb Co Fibrin sealants providing less inflammatory response and methods using same
EP1187623A1 (de) * 1999-06-01 2002-03-20 Bristol-Myers Squibb Company Fibrinmonomer dichtungsmittel zur verhinderung der postchirurgischen verklebungen
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
WO2000077227A1 (en) * 1999-06-16 2000-12-21 Bristol-Myers Squibb Company Fibrin sealant as a transfection/transformation vehicle for gene therapy
US6610043B1 (en) * 1999-08-23 2003-08-26 Bistech, Inc. Tissue volume reduction
US7654998B1 (en) * 1999-08-23 2010-02-02 Aeris Therapeutics, Inc. Tissue volume reduction
CA2316554C (en) 1999-08-25 2007-10-23 Bristol-Myers Squibb Company Applicator and electro-mechanical applicator drive system
US6463335B1 (en) 1999-10-04 2002-10-08 Medtronic, Inc. Temporary medical electrical lead having electrode mounting pad with biodegradable adhesive
ATE286773T1 (de) * 1999-10-29 2005-01-15 Bristol Myers Squibb Co Verfahren zur herstelung von lösungen mit blut- oder plasma-komponenten mit erhöhten konzentrationen
US6730313B2 (en) 2000-01-25 2004-05-04 Edwards Lifesciences Corporation Delivery systems for periadventitial delivery for treatment of restenosis and anastomotic intimal hyperplasia
US6187347B1 (en) 2000-02-09 2001-02-13 Ecosafe, Llc. Composition for arresting the flow of blood and method
JP3576063B2 (ja) * 2000-02-22 2004-10-13 株式会社ホギメディカル 凝固蛋白質を含む可溶性創傷治癒止血セルロース繊維とその製造方法
EP1155706A1 (de) * 2000-05-19 2001-11-21 Xun Yang Huang Apparat zur Herstellung von Fibrinkleber und seine medizinische Anwendung
CA2413337C (en) 2000-06-22 2009-11-24 Thomas E. Davis Bioadhesive compositions and methods of preparation and use
US6921532B1 (en) 2000-06-22 2005-07-26 Spinal Restoration, Inc. Biological Bioadhesive composition and methods of preparation and use
AU2001292609A1 (en) * 2000-09-11 2002-03-26 Closure Medical Corporation Bronchial occlusion method and apparatus
WO2002085284A2 (en) 2000-11-07 2002-10-31 Cryolife, Inc. Expandable foam-like biomaterials and methods
US6942880B1 (en) * 2001-04-09 2005-09-13 Medtronic, Inc. Autologous platelet gel having beneficial geometric shapes and methods of making the same
US7795218B2 (en) 2001-04-12 2010-09-14 Bioaxone Therapeutique Inc. ADP-ribosyl transferase fusion variant proteins
EP1406678B1 (de) * 2001-04-25 2009-01-14 Eidgenössische Technische Hochschule Zürich Arzneimittel freisetzende matrizen zur förderung der wundheilung
US7056331B2 (en) 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
US6994722B2 (en) 2001-07-03 2006-02-07 Scimed Life Systems, Inc. Implant having improved fixation to a body lumen and method for implanting the same
US6848152B2 (en) 2001-08-31 2005-02-01 Quill Medical, Inc. Method of forming barbs on a suture and apparatus for performing same
US6692515B2 (en) * 2001-11-07 2004-02-17 Frank H. Boehm, Jr. Surgical kit for repairing leaks in fluid carrying vessels and organs and method thereof
AU2002361902A1 (en) 2001-12-31 2003-07-24 Ares Medical, Inc. Hemostatic compositions and methods for controlling bleeding
WO2003065877A2 (en) * 2002-02-04 2003-08-14 Damage Control Surgical Technologies, Inc. Method and apparatus for improved hemostasis and damage control operations
DE10204405A1 (de) * 2002-02-04 2003-08-21 Surface Care Gmbh Plasmagel
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7992725B2 (en) 2002-05-03 2011-08-09 Biomet Biologics, Llc Buoy suspension fractionation system
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
AU2003249642A1 (en) 2002-05-24 2003-12-12 Biomet Manufacturing Corp. Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US6773450B2 (en) 2002-08-09 2004-08-10 Quill Medical, Inc. Suture anchor and method
CN1327905C (zh) 2002-09-10 2007-07-25 美国国家红十字会 止血敷料
US8100940B2 (en) 2002-09-30 2012-01-24 Quill Medical, Inc. Barb configurations for barbed sutures
US20040088003A1 (en) 2002-09-30 2004-05-06 Leung Jeffrey C. Barbed suture in combination with surgical needle
JP3640655B2 (ja) * 2002-10-23 2005-04-20 一知 井上 血管新生誘導剤
US20050004599A1 (en) * 2003-06-30 2005-01-06 Mcnally-Heintzelman Karen M. Non-light activated adhesive composite, system, and methods of use thereof
US7943810B2 (en) 2003-02-04 2011-05-17 Buckman Robert F Method and apparatus for hemostasis
JP4585743B2 (ja) * 2003-02-13 2010-11-24 独立行政法人物質・材料研究機構 生体内分解吸収性粘着性医用材料
JP5346148B2 (ja) * 2003-03-28 2013-11-20 エー・デー・ガイストリヒ・ゾーネ・アクチェンゲゼルシャフト・フュール・ヒェーミシェ・インダストリー 抗新生物性組成物および治療方法
US20040224006A1 (en) * 2003-04-21 2004-11-11 Samn Raffaniello Ancrod irradiated, impregnated or coated sutures and other first aid or wound management bandaging materials for minimizing scarring and/or preventing excessive scar formation
US7624487B2 (en) 2003-05-13 2009-12-01 Quill Medical, Inc. Apparatus and method for forming barbs on a suture
US20070073338A1 (en) * 2003-09-04 2007-03-29 Roy Raghunandan Supercutaneous method and device for promoting hemostasis in cannulated patient
JP2007504918A (ja) * 2003-09-12 2007-03-08 マリン ポリマー テクノロジーズ，インコーポレーテッド 血液透析患者における血管アクセスの保存
US20050075729A1 (en) 2003-10-06 2005-04-07 Nguyen Tuoc Tan Minimally invasive valve replacement system
EP3821852A3 (de) 2003-10-06 2021-09-22 Medtronic 3F Therapeutics, Inc. Minimalinvasives klappenersatzsystem
ES2396689T3 (es) 2003-12-11 2013-02-25 Isto Technologies Inc. Sistema de cartílago particulado
EP2664282B1 (de) 2004-05-14 2017-06-21 Ethicon, LLC Nähvorrichtungen
JPWO2005113030A1 (ja) * 2004-05-21 2008-07-31 財団法人化学及血清療法研究所 組織閉鎖剤
WO2005122870A2 (en) 2004-06-14 2005-12-29 Pneumrx, Inc. Lung access device
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
US20050281798A1 (en) * 2004-06-16 2005-12-22 Glen Gong Targeting sites of damaged lung tissue using composition
US7553810B2 (en) * 2004-06-16 2009-06-30 Pneumrx, Inc. Lung volume reduction using glue composition
US20050281799A1 (en) * 2004-06-16 2005-12-22 Glen Gong Targeting damaged lung tissue using compositions
US7608579B2 (en) * 2004-06-16 2009-10-27 Pneumrx, Inc. Lung volume reduction using glue compositions
US20050281739A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue using compositions
US7549984B2 (en) 2004-06-16 2009-06-23 Pneumrx, Inc. Method of compressing a portion of a lung
US20050281740A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
WO2006014567A2 (en) * 2004-07-08 2006-02-09 Pneumrx, Inc. Pleural effusion treatment device, method and material
US8403923B2 (en) * 2004-10-29 2013-03-26 Spinal Restoration, Inc. Injection of fibrin sealant in the absence of corticosteroids in spinal applications
US7597687B2 (en) * 2004-10-29 2009-10-06 Spinal Restoration, Inc. Injection of fibrin sealant including an anesthetic in spinal applications
US8206448B2 (en) * 2004-10-29 2012-06-26 Spinal Restoration, Inc. Injection of fibrin sealant using reconstituted components in spinal applications
US8419722B2 (en) * 2004-10-29 2013-04-16 Spinal Restoration, Inc. Apparatus and method for injection of fibrin sealant in spinal applications
US8124075B2 (en) * 2004-07-16 2012-02-28 Spinal Restoration, Inc. Enhanced biological autologous tissue adhesive composition and methods of preparation and use
JP5014140B2 (ja) 2004-10-18 2012-08-29 タイコ ヘルスケア グループ リミテッド パートナーシップ 接着性縫合構造体およびこれを用いる方法
EP1807514A1 (de) * 2004-10-22 2007-07-18 Benitec, Inc. Therapeutische rnai für behandlung von psoriasis
US20110213464A1 (en) * 2004-10-29 2011-09-01 Whitlock Steven I Injection of fibrin sealant in the absence of corticosteroids in spinal applications
US9125639B2 (en) 2004-11-23 2015-09-08 Pneumrx, Inc. Steerable device for accessing a target site and methods
ATE419019T1 (de) * 2005-01-14 2009-01-15 Eska Implants Gmbh & Co Verfahren zur herstellung einer osteoinduktiv- antiseptischen implantatbeschichtung
ES2426941T3 (es) 2005-02-07 2013-10-25 Hanuman Llc Aparato y procedimiento de concentrados de plasma rico en plaquetas
US7866485B2 (en) 2005-02-07 2011-01-11 Hanuman, Llc Apparatus and method for preparing platelet rich plasma and concentrates thereof
EP1848474B1 (de) 2005-02-07 2013-06-12 Hanuman LLC Vorrichtung und verfahren mit blutplättchenreichem plasmakonzentrat
US7766900B2 (en) 2005-02-21 2010-08-03 Biomet Manufacturing Corp. Method and apparatus for application of a fluid
JP5292533B2 (ja) 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド インプラントおよび関節疾患の治療、置換および治療方法
US20070110788A1 (en) * 2005-11-14 2007-05-17 Hissong James B Injectable formulation capable of forming a drug-releasing device
RU2308287C2 (ru) * 2005-12-26 2007-10-20 Владимир Александрович Макаров Гемостатическое средство
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US20070248653A1 (en) * 2006-04-20 2007-10-25 Cochrum Kent C Hemostatic compositions and methods for controlling bleeding
WO2007127841A2 (en) 2006-04-26 2007-11-08 Arteriocyte Medical Systems, Inc. Compositions and methods of preparation thereof
WO2007127390A2 (en) * 2006-04-28 2007-11-08 Biolife, L.L.C. Materials and methods for wound treatment
US7959943B2 (en) * 2006-05-10 2011-06-14 Medtronics Xomed, Inc. Solvating system and sealant for medical use in the middle or inner ear
US7993675B2 (en) * 2006-05-10 2011-08-09 Medtronic Xomed, Inc. Solvating system and sealant for medical use in the sinuses and nasal passages
US7976873B2 (en) 2006-05-10 2011-07-12 Medtronic Xomed, Inc. Extracellular polysaccharide solvating system for treatment of bacterial ear conditions
US20070264296A1 (en) * 2006-05-10 2007-11-15 Myntti Matthew F Biofilm extracellular polysachharide solvating system
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
NZ574653A (en) * 2006-08-04 2012-11-30 Stb Lifesaving Technologies Inc Solid dressing for treating wounded tissue
US20100040667A1 (en) * 2006-09-07 2010-02-18 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method of treating bone cancer
WO2008036763A2 (en) * 2006-09-20 2008-03-27 Pneumrx, Inc. Tissue adhesive compositions and methods thereof
US7968682B2 (en) * 2006-12-12 2011-06-28 Oregon Health & Science University Degradation-resistant fibrinogen sealants
US20080154233A1 (en) * 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
EP2106263B1 (de) * 2007-01-04 2016-12-21 Hepacore Ltd. Wasserlösliche und reaktive derivate von carboxy-polysacchariden und fibrinogen-konjugate daraus
US8088095B2 (en) * 2007-02-08 2012-01-03 Medtronic Xomed, Inc. Polymeric sealant for medical use
GB2447012B (en) * 2007-02-21 2011-03-16 Pharmacure Health Care Ab Composition for combating epistaxis
EP2146794B1 (de) 2007-04-12 2016-10-19 Biomet Biologics, LLC Fraktionierungssystem für suspensionen mit trennungsschwimmer
WO2008128075A1 (en) 2007-04-12 2008-10-23 Isto Technologies, Inc. Compositions and methods for tissue repair
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
US8915943B2 (en) 2007-04-13 2014-12-23 Ethicon, Inc. Self-retaining systems for surgical procedures
US20090075891A1 (en) * 2007-08-06 2009-03-19 Macphee Martin Methods and dressings for sealing internal injuries
EP2550978B1 (de) 2007-09-27 2014-04-30 Ethicon, LLC Vorrichtung zum Scheiden von Widerhaken auf einer Naht
WO2009086172A2 (en) 2007-12-19 2009-07-09 Angiotech Pharmaceuticals, Inc. Self-retaining sutures with heat-contact mediated retainers
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
US8118834B1 (en) 2007-12-20 2012-02-21 Angiotech Pharmaceuticals, Inc. Composite self-retaining sutures and method
EP2227263A2 (de) * 2007-12-28 2010-09-15 Kuros Biosurgery AG In fibrinschaum integrierte pdgf-fusionsproteine
US8615856B1 (en) 2008-01-30 2013-12-31 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
US8875607B2 (en) 2008-01-30 2014-11-04 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
ES2706295T3 (es) 2008-02-21 2019-03-28 Ethicon Llc Método y aparato para elevar retenedores en suturas de auto-retención
US8216273B1 (en) 2008-02-25 2012-07-10 Ethicon, Inc. Self-retainers with supporting structures on a suture
US8641732B1 (en) 2008-02-26 2014-02-04 Ethicon, Inc. Self-retaining suture with variable dimension filament and method
WO2009108890A1 (en) 2008-02-27 2009-09-03 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
WO2009111338A1 (en) 2008-02-29 2009-09-11 Biomet Manufacturing Corp. A system and process for separating a material
US8518272B2 (en) 2008-04-04 2013-08-27 Biomet Biologics, Llc Sterile blood separating system
US20090259263A1 (en) * 2008-04-11 2009-10-15 Biomet Microfixation, Inc. Apparatus and methods of fixating bone
WO2009129251A2 (en) 2008-04-15 2009-10-22 Angiotech Pharmaceuticals, Inc. Self-retaining sutures with bi-directional retainers or uni-directional retainers
US8012077B2 (en) 2008-05-23 2011-09-06 Biomet Biologics, Llc Blood separating device
EP2303254B1 (de) 2008-06-12 2019-10-30 Medtronic Xomed, Inc. Produkt zur behandlung von chronischen wunden mit einem extrazellulären polymer-substanz-solvatisierungssystem
US8632605B2 (en) 2008-09-12 2014-01-21 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
US20100086576A1 (en) * 2008-10-06 2010-04-08 Myntti Matthew F Antimicrobial composition and methods of making and using same
EP2352440B1 (de) 2008-11-03 2019-02-20 Ethicon LLC Naht mit selbsterhaltender länge und vorrichtung zu ihrer verwendung
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8110208B1 (en) 2009-03-30 2012-02-07 Biolife, L.L.C. Hemostatic compositions for arresting blood flow from an open wound or surgical site
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
US20100256671A1 (en) * 2009-04-07 2010-10-07 Biomedica Management Corporation Tissue sealant for use in noncompressible hemorrhage
WO2010129258A2 (en) 2009-04-27 2010-11-11 Mallinckrodt Inc. Tissue sealant compositions, vascular closure devices, and uses thereof
EP2432422A4 (de) 2009-05-18 2018-01-17 PneumRx, Inc. Querschnittsmodifikation während des einsatzes einer verlängerten vorrichtung zur reduzierung des lungenvolumens
US8367802B2 (en) * 2009-06-18 2013-02-05 Biomedica Management Corporation Method to produce fibrin monomer in acid media for use as tissue sealant
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
WO2011040888A1 (en) * 2009-10-01 2011-04-07 Singapore Health Services Pte Ltd A biodegradable composition or combination and uses thereof
US20110171285A1 (en) * 2009-10-28 2011-07-14 The Texas A&M University System Design of Fibrinogen and Fibrinogen Derived Products with Reduced Bacterial Binding by Using Modified Sequences of Fibrinogen Chains
WO2011090628A2 (en) 2009-12-29 2011-07-28 Angiotech Pharmaceuticals, Inc. Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
NZ702869A (en) 2010-05-04 2016-05-27 Ethicon Llc Self-retaining systems having laser-cut retainers
CA2801271C (en) 2010-06-11 2018-10-30 Ethicon, Llc Suture delivery tools for endoscopic and robot-assisted surgery and methods
US10231721B2 (en) 2010-06-24 2019-03-19 St. Croix Surgical Systems, Llc Failsafe percutaneous wound barrier
CA2816326C (en) 2010-11-03 2020-12-15 Ethicon, Llc Drug-eluting self-retaining sutures and methods relating thereto
MX342984B (es) 2010-11-09 2016-10-19 Ethicon Llc Suturas de autorretencion de emergencia y envasado de estas.
AU2012230716B2 (en) 2011-03-23 2016-05-19 Ethicon Llc Self-retaining variable loop sutures
WO2012140650A2 (en) 2011-04-12 2012-10-18 Hepacore Ltd. Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
EP2706845B1 (de) 2011-05-10 2021-06-23 Next Science IP Holdings Pty Ltd Antimikrobieller feststoff sowie verfahren zu seiner herstellung und verwendung
US20130172931A1 (en) 2011-06-06 2013-07-04 Jeffrey M. Gross Methods and devices for soft palate tissue elevation procedures
DE102011122227A1 (de) 2011-12-23 2013-06-27 Medizinische Hochschule Hannover Verfahren und Vorrichtung zur Herstellung eines bioartifiziellen Gewebekonstrukts
US20130202656A1 (en) 2012-02-03 2013-08-08 Dynasil Biomedical Corporation Systems and kits for the fabrication of tissue patches
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
BR112014028068A2 (pt) 2012-09-25 2017-08-08 Stem Cell Partners Llc método e aparelho para preparar soro de trombina de doador único
US10016527B2 (en) 2012-10-23 2018-07-10 Orthovita, Inc. Materials and methods for repair of cartilage defects
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US8906856B2 (en) * 2012-12-31 2014-12-09 Biomedica Mangement Corporation Single component fibrin hemostat
CN105007841A (zh) * 2012-12-31 2015-10-28 乔治·D.·福卢什 用于大量出血的冻干纤维蛋白封闭剂
WO2014121000A1 (en) * 2013-02-01 2014-08-07 Xcede Technologies, Inc. Minimally invasive surgery, including vascular closure, and associated sealants
MX366410B (es) 2013-02-12 2019-07-08 Replicel Life Sciences Inc Composiciones y metodos para tratamiento y reparacion de tendones.
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
RU2522879C1 (ru) * 2013-04-23 2014-07-20 ОАО "Научно-исследовательский институт текстильных материалов" (ОАО "НИИТМ") Биодеградируемое гемостатическое лекарственное средство для остановки капиллярных и паренхиматозных кровотечений
IL230151A0 (en) * 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL230150A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing zymogens
US10500233B2 (en) 2014-02-12 2019-12-10 Replicel Life Sciences Inc. Compositions and methods for treating bone, joints and cartilage
IL231230A0 (en) 2014-02-27 2014-08-31 Omrix Biopharmaceuticals Ltd Fibrinogen preparation
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
BR102014011436A8 (pt) * 2014-05-12 2018-01-09 Univ Estadual Paulista Julio De Mesquita Filho selante de fibrina para uso tópico, método de formação do mesmo e seu uso
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
US9932388B2 (en) 2014-11-13 2018-04-03 Hemarus Therapeutics Limited Chromatographic process for producing high purity fibrinogen and thrombin
US9713810B2 (en) 2015-03-30 2017-07-25 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9757721B2 (en) 2015-05-11 2017-09-12 Biomet Biologics, Llc Cell washing plunger using centrifugal force
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
US10588998B2 (en) 2015-08-07 2020-03-17 Xcede Technologies, Inc. Adhesive compositions and related methods
US10501715B1 (en) 2015-09-11 2019-12-10 Mark H. Widick System for the formation of fibrin foam
RU2628809C1 (ru) * 2016-06-30 2017-08-22 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения Российской Федерации (ФГБУ ГНЦ Минздрава России) Гемостатическая губка и способ ее получения
FR3055805B1 (fr) 2016-09-09 2020-05-15 Assistance Publique - Hopitaux De Paris (Ap-Hp) Biomateriau a usage therapeutique
CN108220233B (zh) * 2016-12-21 2021-07-09 上海透景诊断科技有限公司 细胞分离器具表面处理方法、相关器具、外周血稀有细胞或循环肿瘤细胞快速高效分离方法
CN107589246B (zh) * 2017-03-07 2019-10-01 上海原科实业发展有限公司 一种纤维蛋白激活剂、其制备方法，包括该激活剂的试剂盒及采用该试剂盒的检测方法
RU179063U1 (ru) * 2017-07-03 2018-04-25 Федеральное государственное бюджетное образовательное учреждение высшего образования "Амурская государственная медицинская академия" Министерства здравоохранения Российской Федерации Салфетка с фибрином
CA3078625C (en) 2017-10-09 2023-01-17 Terumo Bct Biotechnologies, Llc Lyophilization container and method of using same
US11154637B2 (en) 2018-11-07 2021-10-26 Industrial Technology Research Institute Biodegradable sealant and use of a biodegradable sealant in manufacture of an agent for biological tissue adhesion or repair
CN109679946B (zh) * 2019-01-04 2020-11-13 宁波艾捷康宁生物科技有限公司 一种血液病毒rna保护剂及采血管
WO2020185909A2 (en) 2019-03-14 2020-09-17 Terumo Bct Biotechnologies, Llc Lyophilization loading tray assembly and system
RU2749983C1 (ru) * 2020-11-09 2021-06-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ герметизации панкреато-кишечного анастомоза с применением фибринового композита
EP4274625A1 (de) * 2021-01-07 2023-11-15 Baxter International Inc. Thrombinfreie hämostatische materialien, verfahren zur herstellung und verwendungen davon
WO2023222770A1 (en) 2022-05-17 2023-11-23 Julius-Maximilians-Universitaet Wuerzburg Novel recombinant fibrinogen variants for fibrin sealants for surgical wound care

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2533004A (en) * 1943-10-27 1950-12-05 John D Ferry Fibrin clots and methods for preparing the same
CH586233A5 (de) * 1971-01-18 1977-03-31 Pentapharm Ag
GB1417003A (en) * 1972-06-22 1975-12-10 Radiochemical Centre Ltd Stabilisation of fibrinogen
US3915640A (en) * 1974-08-06 1975-10-28 Warner Lambert Co Method and composition for detecting fibrin monomers and fibrin degradation products
SU663404A1 (ru) * 1976-12-30 1979-05-25 Московский Ордена Ленина И Ордена Трудового Красного Знамени Государственный Университет Им. М.В.Ломоносова Способ получени фибрин-мономера
US4442650A (en) * 1977-12-15 1984-04-17 Sivachenko Eugene W Girder construction
US4167823A (en) * 1978-06-21 1979-09-18 Kumming Deborah G Coagulation puzzle for teaching coagulation theory
JPS5598196A (en) * 1979-01-16 1980-07-25 Meito Sangyo Kk Fractionation of fibrinogen or its constituents and their use
SE417342B (sv) * 1979-02-05 1981-03-09 Nya Asfalt Ab Forfarande och anordning for grundleggning av for tillverkade anleggningar i land
AT359653B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
DE3017707A1 (de) * 1980-05-08 1981-11-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und reagens zum nachweis von fibrinmonomer
US4488198A (en) * 1981-01-15 1984-12-11 Sundstrand Corporation Protective circuit for clutchless parallel generating system
US4455290A (en) * 1981-04-02 1984-06-19 Research Corporation Inhibition of fibrin polymerization by a peptide isolated from fibrin Fragment D1
US4495278A (en) * 1981-04-27 1985-01-22 Baxter Travenol Laboratories, Inc. Process for making novel blood clotting enzyme compositions
US4480029A (en) * 1981-04-27 1984-10-30 Baxter Travenol Laboratories, Inc. Biological indicators and their use
US4442655A (en) * 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
ATE13810T1 (de) * 1981-06-25 1985-07-15 Serapharm Gmbh & Co Kg Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundabdeckung.
ATE20824T1 (de) * 1981-06-25 1986-08-15 Serapharm Gmbh & Co Kg Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung.
EP0068149A3 (de) * 1981-06-25 1983-07-20 Serapharm GmbH & Co. KG Fibrinogen-haltiges Trockenpräparat, dessen Herstellung und Verwendung
US4438198A (en) * 1981-09-30 1984-03-20 Trimedyne, Inc. Biochemically active matrix for use in a bio-artificial organ
DE3203775A1 (de) * 1982-02-04 1983-08-11 Behringwerke Ag, 3550 Marburg Fibrinogenzubereitung, verfahen zu ihrer herstellungund ihre verwendung
DE3230849A1 (de) * 1982-08-19 1984-02-23 Behringwerke Ag, 3550 Marburg Pasteurisiertes human-fibrinogen (hf) und verfahren zu dessen herstellung
US5357042A (en) * 1984-04-23 1994-10-18 The General Hospital Corporation Synthetic peptides capable of eliciting fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity
US4927916A (en) * 1984-04-23 1990-05-22 The General Hospital Corporation Method of producing fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity using fibrin-specific peptides
DE3430906A1 (de) * 1984-08-22 1986-02-27 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur bestimmung von fibrinmonomer in plasma
US4928603A (en) * 1984-09-07 1990-05-29 The Trustees Of Columbia University In The City Of New York Method of preparing a cryoprecipitated suspension and use thereof
US4627879A (en) * 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
US5223420A (en) * 1985-03-01 1993-06-29 Institut National De La Sante Et De La Recherche Medicale Elastin-based product, a procedure for its preparation and its biological applications; in particular as biomaterials and artificial supports
SE447579B (sv) * 1985-04-01 1986-11-24 Biopool Ab Solubiliserbar, fibrinbaserad komposition och anvendning av kompositionen vid bestemning av fibrinolysparametrar
DE3622642A1 (de) * 1986-07-05 1988-01-14 Behringwerke Ag Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung
DD261844A1 (de) * 1986-07-09 1988-11-09 Adw Ddr Verfahren zur praezipitation von fibrinmonomeren
US4714457A (en) * 1986-09-15 1987-12-22 Robert Alterbaum Method and apparatus for use in preparation of fibrinogen from a patient's blood
DK475386D0 (da) * 1986-10-03 1986-10-03 Weis Fogh Ulla Sivertsen Fremgangsmaade og apparat til fremstilling af biologiske stoffer
US4915847A (en) * 1987-08-04 1990-04-10 Baxter International Inc. Cryoglobulin separation
GB8628398D0 (en) * 1986-11-27 1986-12-31 Central Blood Lab Authority Pharmaceutically-active conjugates
US4709037A (en) * 1987-02-17 1987-11-24 Hoechst Celanese Corporation Biotinylating agents
US5175087A (en) * 1987-07-06 1992-12-29 Biopool International, Inc. Method of performing tissue plasminogen activator assay
DE3808048A1 (de) * 1988-03-11 1989-09-21 Behringwerke Ag Verfahren zum affinitaetschromatografischen reinigen von faktor xiii
US5290552A (en) * 1988-05-02 1994-03-01 Matrix Pharmaceutical, Inc./Project Hear Surgical adhesive material
AT397203B (de) * 1988-05-31 1994-02-25 Immuno Ag Gewebeklebstoff
DE3819923A1 (de) * 1988-06-11 1989-12-21 Behringwerke Ag Fibrin(ogen)derivate, verfahren zu ihrer herstellung und ihre verwendung
DE68925112T2 (de) * 1988-10-17 1996-07-11 Molecular Devices Corp Haptenderivatisierte aufnahmemembran und diagnostische tests, die eine solche membran verwenden
JPH02129234A (ja) * 1988-11-09 1990-05-17 Kanebo Ltd 難燃性フェノール系樹脂プリプレグ
JPH02129224A (ja) * 1988-11-10 1990-05-17 Terumo Corp フィブリンの製造法
DE3900493A1 (de) * 1989-01-10 1990-07-12 Thomae Gmbh Dr K Verfahren zur bestimmung der fibrinolytischen gesamtaktivitaet im plasma
US5026785A (en) * 1989-05-12 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Avidin and streptavidin modified water-soluble polymers such as polyacrylamide, and the use thereof in the construction of soluble multivalent macromolecular conjugates
CA1335361C (en) * 1989-05-24 1995-04-25 Andrei Z. Budzynski Thrombus-targeted complexes of plasminogen activator and fibrin fragments
US5226877A (en) * 1989-06-23 1993-07-13 Epstein Gordon H Method and apparatus for preparing fibrinogen adhesive from whole blood
FR2649982B1 (fr) * 1989-07-20 1991-09-27 Inst Nat Sante Rech Med Membrane biologique artificielle
DE69007006T2 (de) * 1989-09-29 1994-08-25 Rohm & Haas Ligand enthaltendes Medium für chromatographische Trennung, Verfahren zur dessen Herstellung und dessen Verwendung zur Isolierung von synthetischen oder natürlichen Molekülen von einer Fluidmischung.
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5030215A (en) * 1990-01-03 1991-07-09 Cryolife, Inc. Preparation of fibrinogen/factor XIII precipitate
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
US5185001A (en) * 1990-01-18 1993-02-09 The Research Foundation Of State University Of New York Method of preparing autologous plasma fibrin and application apparatus therefor
US5180828A (en) * 1990-02-09 1993-01-19 Molecular Devices Corporation Chromophoric reagents for incorporation of biotin or other haptens into macromolecules
US5420250A (en) * 1990-08-06 1995-05-30 Fibrin Corporation Phase transfer process for producing native plasma protein concentrates
JPH04233458A (ja) * 1990-08-23 1992-08-21 New York Blood Center Inc 可溶性フィブリン様モノマーを使ったアッセイ
EP0485904B1 (de) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycinderivate
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
CH681693A5 (de) * 1991-02-28 1993-05-14 Pentapharm Ag
EP0534178B1 (de) * 1991-09-27 2001-04-18 Omrix Biopharmaceuticals S.A. Verbesserter Gewebekleber, zubereitet aus Kryopräzipitat
US5527692A (en) * 1991-12-31 1996-06-18 Zymogenetics, Inc. Methods for producing thrombin
US5272074A (en) * 1992-04-23 1993-12-21 Mcmaster University Fibrin coated polymer surfaces
US5443959A (en) * 1992-09-09 1995-08-22 Tokuyama Corporation Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof
CN1091315A (zh) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 血纤维蛋白封闭剂组合物及其使用方法
US5292416A (en) * 1992-11-13 1994-03-08 Indiana University Foundation Pulsed-field separation of polysaccharides in capillaries
US5520885A (en) * 1993-01-19 1996-05-28 Thermogenesis Corporation Fibrinogen processing apparatus, method and container
US5330974A (en) * 1993-03-01 1994-07-19 Fibratek, Inc. Therapeutic fibrinogen compositions
AU696691C (en) * 1993-03-12 2003-09-18 American National Red Cross, The Supplemented and unsupplemented tissue sealants, methods of their production and use
US5464471A (en) * 1994-11-10 1995-11-07 Whalen Biomedical Inc. Fibrin monomer based tissue adhesive
US5510102A (en) * 1995-01-23 1996-04-23 The Regents Of The University Of California Plasma and polymer containing surgical hemostatic adhesives
EP0841108A1 (de) * 1996-11-06 1998-05-13 Norsk Hydro ASA Verfahren zur Verbindung von Metallelementen

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ES2065294A1 (es) 1995-02-01
FI934440A0 (fi) 1993-10-08
US5962026A (en) 1999-10-05
IL107211A (en) 1997-09-30
US6048966A (en) 2000-04-11
PL176202B1 (pl) 1999-04-30
NO933624D0 (no) 1993-10-08
FI934440A (fi) 1994-04-09
DK0592242T3 (da) 2003-10-27
AU4887893A (en) 1994-04-21
PL173858B1 (pl) 1998-05-29
IL107211A0 (en) 1994-01-25
US5763410A (en) 1998-06-09
EP0592242B1 (de) 2003-07-09
US5962420A (en) 1999-10-05
ES2065294B1 (es) 1995-11-01
AU676201B2 (en) 1997-03-06
CA2510981C (en) 2007-02-13
US5750657A (en) 1998-05-12
EP1266666A2 (de) 2002-12-18
CA2566574A1 (en) 1994-04-09
SG49640A1 (en) 1998-06-15
CA2108104C (en) 2005-09-27
ES2202306T3 (es) 2004-04-01
ATE244581T1 (de) 2003-07-15
KR940008697A (ko) 1994-05-16
HU9302839D0 (en) 1994-01-28
JP3771284B2 (ja) 2006-04-26
EP0592242A1 (de) 1994-04-13
JPH06199685A (ja) 1994-07-19
NO933624L (no) 1994-04-11
CA2510981A1 (en) 1994-04-09
CA2108104A1 (en) 1994-04-09
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US5804428A (en) 1998-09-08
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US5770194A (en) 1998-06-23
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US6077507A (en) 2000-06-20
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US5739288A (en) 1998-04-14
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HU218898B (hu) 2000-12-28
US5773418A (en) 1998-06-30
US5763411A (en) 1998-06-09
US6262236B1 (en) 2001-07-17
DE69333080T2 (de) 2004-04-15
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