DE69334304D1 - Verfahren zur herstellung diagnostischer mittel aus mikrokapseln mit hyaluronsäure - Google Patents

Verfahren zur herstellung diagnostischer mittel aus mikrokapseln mit hyaluronsäure

Info

Publication number
DE69334304D1
DE69334304D1 DE69334304T DE69334304T DE69334304D1 DE 69334304 D1 DE69334304 D1 DE 69334304D1 DE 69334304 T DE69334304 T DE 69334304T DE 69334304 T DE69334304 T DE 69334304T DE 69334304 D1 DE69334304 D1 DE 69334304D1
Authority
DE
Germany
Prior art keywords
microspheres
wall
hyaluronic acid
diagnostic means
micro capsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69334304T
Other languages
English (en)
Inventor
Andrew Derek Sutton
Richard Alan Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Quadrant Drug Delivery Ltd
Original Assignee
Quadrant Drug Delivery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10723265&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69334304(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Quadrant Drug Delivery Ltd filed Critical Quadrant Drug Delivery Ltd
Application granted granted Critical
Publication of DE69334304D1 publication Critical patent/DE69334304D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
DE69334304T 1992-10-10 1993-10-08 Verfahren zur herstellung diagnostischer mittel aus mikrokapseln mit hyaluronsäure Expired - Lifetime DE69334304D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929221329A GB9221329D0 (en) 1992-10-10 1992-10-10 Preparation of further diagnostic agents

Publications (1)

Publication Number Publication Date
DE69334304D1 true DE69334304D1 (de) 2010-01-21

Family

ID=10723265

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69334304T Expired - Lifetime DE69334304D1 (de) 1992-10-10 1993-10-08 Verfahren zur herstellung diagnostischer mittel aus mikrokapseln mit hyaluronsäure
DE69333345T Revoked DE69333345T2 (de) 1992-10-10 1993-10-08 Verfahren zur herstellung von mikrokapseln

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69333345T Revoked DE69333345T2 (de) 1992-10-10 1993-10-08 Verfahren zur herstellung von mikrokapseln

Country Status (11)

Country Link
US (7) US6344182B1 (de)
EP (2) EP0663840B1 (de)
JP (2) JPH08505366A (de)
AT (2) ATE451127T1 (de)
CA (1) CA2146783C (de)
DE (2) DE69334304D1 (de)
DK (1) DK0663840T3 (de)
ES (2) ES2214477T3 (de)
GB (4) GB9221329D0 (de)
HK (3) HK1007959A1 (de)
WO (1) WO1994008627A1 (de)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6391343B1 (en) 1991-01-15 2002-05-21 Hemosphere, Inc. Fibrinogen-coated particles for therapeutic use
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) * 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
US7425543B2 (en) * 1992-11-16 2008-09-16 The Corporation Of Mercer University Microencapsulated materials and method of making same
US6051256A (en) * 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
PT796090E (pt) * 1994-12-16 2003-07-31 Elan Drug Delivery Ltd Microparticulas reticuladas e sua utilizacao como veiculos terapeuticos
US5955108A (en) * 1994-12-16 1999-09-21 Quadrant Healthcare (Uk) Limited Cross-linked microparticles and their use as therapeutic vehicles
WO1996040277A2 (en) * 1995-06-07 1996-12-19 Brown University Research Foundation Spray dried polymeric microparticles containing imaging agents
AU702955B2 (en) * 1996-05-17 1999-03-11 Quadrant Healthcare (Uk) Limited Microparticles and their use in wound therapy
GB9610830D0 (en) 1996-05-23 1996-07-31 Andaris Ltd Use of hollow microcapsules
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5976501A (en) * 1996-06-07 1999-11-02 Molecular Biosystems, Inc. Use of pressure resistant protein microspheres encapsulating gases as ultrasonic imaging agents for vascular perfusion
US6017310A (en) * 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
EP0949932A1 (de) * 1996-10-19 1999-10-20 Quadrant Healthcare (UK) Limited Verwendung von mikrokohlkugeln zur diagnose und therapie
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
GB9701274D0 (en) 1997-01-22 1997-03-12 Andaris Ltd Ultrasound contrast imaging
GB9703673D0 (en) * 1997-02-21 1997-04-09 Bradford Particle Design Ltd Method and apparatus for the formation of particles
AU741528B2 (en) 1997-06-05 2001-12-06 Hemosphere, Inc. Fibrinogen-coated microspheres
US6045777A (en) * 1997-06-30 2000-04-04 Acusphere, Inc. Method for enhancing the echogenicity and decreasing the attenuation of microencapsulated gases
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6051546A (en) * 1997-10-28 2000-04-18 General Electric Company Silicone composition for bar soap applications
GB9726664D0 (en) * 1997-12-17 1998-02-18 Nycomed Imaging As Improvements in or relating to ultrasonography
US6451349B1 (en) 1998-08-19 2002-09-17 Quadrant Healthcare (Uk) Limited Spray-drying process for the preparation of microparticles
EP1202670A4 (de) * 1999-08-13 2004-11-10 Point Biomedical Corp Hohle mikrokugeln mit kontrollierter zerbrechlichkeit zur medizinischen verwendung
NL1014175C2 (nl) 2000-01-25 2001-07-26 Oldelft B V Ultrageluid probe.
CA2401879A1 (en) * 2000-03-06 2001-09-13 Stephan Mangin Embolic agents visible under ultrasound
WO2001080831A2 (en) 2000-04-27 2001-11-01 Verion Inc. Zero order release and temperature-controlled microcapsules and process for the preparation thereof
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
ES2525087T5 (es) 2000-05-10 2018-06-28 Novartis Ag Polvos basados en fosfolípidos para administración de fármacos
US7575761B2 (en) * 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
WO2002009669A2 (en) * 2000-08-01 2002-02-07 Inhale Therapeutic Systems, Inc. Apparatus and process to produce particles having a narrow size distribution and particles made thereby
AU2001291243A1 (en) 2000-09-27 2002-04-08 Verion Inc. Instant water dissolvable encapsulate and process
US7563457B2 (en) * 2001-10-02 2009-07-21 The Regents Of The University Of California Nanoparticle assembled hollow spheres
EP1446104B2 (de) * 2001-11-01 2011-08-03 Novartis AG Sprühtrocknungsverfahren
ES2364636T3 (es) 2001-12-19 2011-09-08 Novartis Ag Administración pulmonar de aminoglucósidos.
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
WO2003059884A1 (en) 2001-12-21 2003-07-24 X-Ceptor Therapeutics, Inc. Modulators of lxr
US20030119203A1 (en) * 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) * 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US7131997B2 (en) * 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7462366B2 (en) * 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7053134B2 (en) * 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
GB0216562D0 (en) * 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
WO2003105917A2 (en) 2002-06-12 2003-12-24 Scimed Life Systems, Inc. Bulking agents
DE10234165B4 (de) * 2002-07-26 2008-01-03 Advanced Micro Devices, Inc., Sunnyvale Verfahren zum Füllen eines Grabens, der in einem Substrat gebildet ist, mit einem isolierenden Material
US7449236B2 (en) * 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US20040076582A1 (en) * 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US7314763B2 (en) * 2002-08-27 2008-01-01 Kimberly-Clark Worldwide, Inc. Fluidics-based assay devices
US7285424B2 (en) * 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7432105B2 (en) * 2002-08-27 2008-10-07 Kimberly-Clark Worldwide, Inc. Self-calibration system for a magnetic binding assay
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
CN1694689A (zh) * 2002-09-30 2005-11-09 阿库斯菲尔公司 供吸入的缓释多孔微粒
US7588825B2 (en) * 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7781172B2 (en) * 2003-11-21 2010-08-24 Kimberly-Clark Worldwide, Inc. Method for extending the dynamic detection range of assay devices
US20040106190A1 (en) * 2002-12-03 2004-06-03 Kimberly-Clark Worldwide, Inc. Flow-through assay devices
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US7247500B2 (en) * 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040121334A1 (en) * 2002-12-19 2004-06-24 Kimberly-Clark Worldwide, Inc. Self-calibrated flow-through assay devices
AU2003302329B2 (en) 2002-12-30 2010-01-07 Novartis Ag Prefilming atomizer
US20040197819A1 (en) * 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7851209B2 (en) * 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US7479112B2 (en) * 2003-08-26 2009-01-20 Cardiac Pacemakers, Inc. Acoustic physiological sensor
US7976823B2 (en) * 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
CA2533887A1 (en) * 2003-09-30 2005-04-14 Acusphere, Inc. Injectable, oral, or topical sustained release pharmaceutical formulations
AU2004285595A1 (en) * 2003-10-31 2005-05-12 Point Biomedical Corporation Reconstitutable microsphere compositions useful as ultrasonic contrast agents
US7901770B2 (en) * 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
US7713748B2 (en) * 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) * 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US20050136550A1 (en) * 2003-12-19 2005-06-23 Kimberly-Clark Worldwide, Inc. Flow control of electrochemical-based assay devices
US7943089B2 (en) * 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
EP1697035B1 (de) * 2003-12-22 2017-11-15 Warren H. Finlay Pulverbildung durch atmosphärische sprühgefriertrocknung
DE102004008367A1 (de) * 2004-02-20 2005-09-22 Siemens Ag Verfahren zur Aufnahme zweidimensionaler Bilder im Inneren eines blutdurchflossenen Gefäßes mittels optischer Kohärenztomographie
US7736671B2 (en) * 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US7669349B1 (en) * 2004-03-04 2010-03-02 TD*X Associates LP Method separating volatile components from feed material
US8076117B2 (en) * 2004-03-18 2011-12-13 Mayo Foundation For Medical Education And Research Microbial biofilm removal methods and systems
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
US20050238870A1 (en) * 2004-04-22 2005-10-27 Marcia Buiser Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US20080019904A1 (en) * 2004-06-29 2008-01-24 Koninklijke Philips Electronics, N.V. System For Manufacturing Micro-Sheres
US7521226B2 (en) 2004-06-30 2009-04-21 Kimberly-Clark Worldwide, Inc. One-step enzymatic and amine detection technique
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7727555B2 (en) * 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) * 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US20070004973A1 (en) * 2005-06-15 2007-01-04 Tan Sharon M L Tissue treatment methods
US9463426B2 (en) * 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
BRPI0612611A2 (pt) 2005-07-05 2010-12-07 Lonza Ag processo de secagem por pulverização para produzir um pó ou granulado seco de carnitina
US20070083219A1 (en) * 2005-10-12 2007-04-12 Buiser Marcia S Embolic coil introducer sheath locking mechanisms
US8007509B2 (en) * 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US20070148211A1 (en) * 2005-12-15 2007-06-28 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
CA2631493A1 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for pulmonary or nasal administration
US7913223B2 (en) * 2005-12-16 2011-03-22 Dialogic Corporation Method and system for development and use of a user-interface for operations, administration, maintenance and provisioning of a telecommunications system
US8152839B2 (en) * 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US20070142859A1 (en) * 2005-12-19 2007-06-21 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7501179B2 (en) * 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US20070142560A1 (en) * 2005-12-21 2007-06-21 Young-Ho Song Block copolymer particles
US7947368B2 (en) * 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US20070299461A1 (en) * 2006-06-21 2007-12-27 Boston Scientific Scimed, Inc. Embolic coils and related components, systems, and methods
FR2904219B1 (fr) * 2006-07-28 2010-08-13 Flamel Tech Sa Microparticules a base de copolymere amphiphile et de principe(s) actif(s) a liberation modifiee et formulations pharmaceutiques en contenant
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US20080145658A1 (en) * 2006-12-15 2008-06-19 Boston Scientific Scimed, Inc. Freeze Thaw Methods For Making Polymer Particles
US8696353B2 (en) * 2007-12-18 2014-04-15 Koninklijke Philips N.V. Antimicrobial filled capsules in an ultrasound field for treatment of dental biofilm
KR101061224B1 (ko) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 Ｘ 선을 이용한 유동정보 측정용 캡슐
US9827205B2 (en) * 2008-12-12 2017-11-28 Mallinckrodt Pharma Ip Trading D.A.C. Dry powder fibrin sealant
US20100178245A1 (en) * 2009-01-13 2010-07-15 Arnsdorf Morton F Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites
JP5804453B2 (ja) * 2009-05-14 2015-11-04 国立大学法人 東京大学 結晶性ポリオール微粒子及びその調製方法
US20100312118A1 (en) * 2009-06-03 2010-12-09 Horzewski Michael J Systems and Methods for Perfusion Enhanced Diagnostic Imaging
US8708159B2 (en) * 2011-02-16 2014-04-29 Oakwood Laboratories, Llc Manufacture of microspheres using a hydrocyclone
JP6108382B2 (ja) * 2012-09-04 2017-04-05 国立大学法人九州大学 新規イオン液体およびその用途
JP6480940B2 (ja) * 2013-12-19 2019-03-13 エアロゾル セラピューティクス， エルエルシー 大気圧スプレーフリーズドライのための組成物および方法
US10463334B2 (en) * 2018-01-16 2019-11-05 Wisconsin Alumni Research Foundation System and method for non-invasive, quantitative measurements of blood flow parameters in vascular networks
DE102022120500B3 (de) * 2022-08-15 2023-10-12 FILK Freiberg Institute gGmbH Verfahren und Vorrichtung zur Herstellung von Hohlkugeln aus Kollagen und Kollagenderivaten und Hohlkugeln aus Kollagen und Gelatine

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2797201A (en) 1953-05-11 1957-06-25 Standard Oil Co Process of producing hollow particles and resulting product
US3501419A (en) 1962-06-07 1970-03-17 Tee Pak Inc Cellulose microspherical product
US3565559A (en) * 1968-03-11 1971-02-23 Sumitomo Chemical Co Process for making microcapsules
AU439432B2 (en) 1968-11-28 1972-08-15 Dulux Australia Ltd Polymer and coating composition
US4173488A (en) 1968-12-23 1979-11-06 Champion International Corporation Oil-in-water emulsions containing hydropholeic starch
US3781230A (en) 1968-12-23 1973-12-25 Champion Int Corp Microcapsular opacifier system
US3960583A (en) 1974-05-02 1976-06-01 Philadelphia Quartz Company Method of preparing modified hollow, largely spherical particles by spray drying
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
JPS5134879A (en) 1974-09-19 1976-03-24 Eisai Co Ltd Bishochukuryushinoseizoho
US4089800A (en) 1975-04-04 1978-05-16 Ppg Industries, Inc. Method of preparing microcapsules
JPS5231981A (en) 1975-08-18 1977-03-10 Takeda Chem Ind Ltd Microcapsule preparation method
US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4316391A (en) 1979-11-13 1982-02-23 Ultra Med, Inc. Flow rate measurement
JPS5933017B2 (ja) 1980-03-14 1984-08-13 株式会社成和化成 マイクロカプセル用壁財
US4442843A (en) 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
CA1170569A (en) 1980-11-17 1984-07-10 Julia S. Rasor Microbubble precursors and methods for their production and use
US4420442A (en) 1981-04-13 1983-12-13 Pq Corporation Manufacturing process for hollow microspheres
DE3141641A1 (de) 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
ZA831343B (en) 1982-04-08 1983-11-30 Pq Corp Hollow microspheres with organosilicon-silicate surfaces
US4960351A (en) 1982-04-26 1990-10-02 California Institute Of Technology Shell forming system
US4572203A (en) 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
DE3324754A1 (de) 1983-07-06 1985-01-17 Schering AG, 1000 Berlin und 4709 Bergkamen Ultraschallkontrastmittel sowie dessen herstellung
US4500676A (en) * 1983-12-15 1985-02-19 Biomatrix, Inc. Hyaluronate modified polymeric articles
US5177687A (en) 1984-02-03 1993-01-05 Bell & Howell Phillipsburg Co. Insertion machine with postage categorization and selective merchandising
US4582312A (en) 1984-09-07 1986-04-15 Bell & Howell Company Printing apparatus for insertion machine
GB8601100D0 (en) * 1986-01-17 1986-02-19 Cosmas Damian Ltd Drug delivery system
US4829443A (en) 1987-02-02 1989-05-09 Pitney Bowes Inc. Insertion machine with computerized postage search and prioritized selection of inserts
US4800506A (en) 1987-03-13 1989-01-24 Pitney Bowes Inc. Apparatus for preparing mail pieces
US4800505A (en) 1987-03-13 1989-01-24 Pitney Bowes Inc. Mail preparation system
US5690954A (en) * 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
US5069936A (en) * 1987-06-25 1991-12-03 Yen Richard C K Manufacturing protein microspheres
JPH01123626A (ja) * 1987-11-06 1989-05-16 Terumo Corp 被覆型マイクロカプセルおよびその製造法
US4844882A (en) 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US5425366A (en) * 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
DE3803971C2 (de) 1988-02-05 1997-09-18 Schering Ag Ultraschallkontrastmittel
KR0133132B1 (ko) * 1988-02-05 1998-04-17 쉐링 아게, 베를린 운트 베르크카멘 초음파 조영제, 이의 제법 및 이의 진단제로서의 용도
US4981625A (en) 1988-03-14 1991-01-01 California Institute Of Technology Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops
US4957656A (en) 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
GB8900376D0 (en) * 1989-01-09 1989-03-08 Nycomed As Iodinated esters
DE69001683T2 (de) 1989-01-31 1993-12-02 Coletica Lyon Verwendung von Atelokollagen und Polyholosiden, z.B. Glykosaminoglykan enthaltende Lösungen zur Herstellung von Mikrokapseln die danach erhaltenen Mikrokapseln und Verfahren zu deren Herstellung; Präparate, welche Nahrungsstoffe, Medikamente oder kosmetische Zusammensetzungen enthalten.
US5543162A (en) * 1989-02-10 1996-08-06 Alko Group Ltd. Polymeric capsules, method of making the same, and foodstuffs containing the same
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
CA2071840C (en) 1989-11-06 1997-02-04 Edith Mathiowitz Method for producing protein microspheres
US5271961A (en) * 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5088499A (en) 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
DE4004430A1 (de) 1990-02-09 1991-08-14 Schering Ag Aus polyaldehyden aufgebaute kontrastmittel
US5067088A (en) 1990-02-16 1991-11-19 Johnson & Quin, Inc. Apparatus and method for assembling mass mail items
GB9003821D0 (en) * 1990-02-20 1990-04-18 Danbiosyst Uk Diagnostic aid
US4968562A (en) 1990-02-27 1990-11-06 Minnesota Mining And Manufacturing Company Hollow acid-free acrylate polymeric microspheres having multiple small voids
FR2658720B1 (fr) * 1990-02-28 1994-09-09 Oreal Composition cosmetique sous forme de poudre compactee contenant des microspheres creuses en materiau synthetique thermoplastique.
IN172208B (de) 1990-04-02 1993-05-01 Sint Sa
FR2660864A1 (fr) 1990-04-13 1991-10-18 Guerbet Sa Composition de contraste, procede de preparation de cette composition et application a l'imagerie.
US5190982A (en) 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5205287A (en) 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5137928A (en) 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5215680A (en) 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
JPH04145131A (ja) 1990-10-04 1992-05-19 Japan Synthetic Rubber Co Ltd 中空重合体粒子の製造方法
US5310540A (en) 1990-10-05 1994-05-10 Sintetica Sa Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
DE4100470A1 (de) 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
US5114128A (en) 1991-02-27 1992-05-19 U.S. News & World Report, L.P. Process and apparatus for personalizing magazines, books and other print media
GB9106686D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106673D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
JP3024812B2 (ja) 1991-04-15 2000-03-27 松下電工株式会社 多重伝送システム
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
IT1247472B (it) * 1991-05-31 1994-12-17 Fidia Spa Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
US5266781A (en) 1991-08-15 1993-11-30 Datacard Corporation Modular card processing system
US5317654A (en) 1991-09-26 1994-05-31 Inscerco Mfg. Inc. Selective collating and inserting apparatus
US5207412A (en) 1991-11-22 1993-05-04 Xerox Corporation Multi-function document integrater with control indicia on sheets
US5196183A (en) * 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
US5674468A (en) 1992-03-06 1997-10-07 Nycomed Imaging As Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons
ATE204750T1 (de) 1992-06-12 2001-09-15 Teijin Ltd Pharmazeutische zubereitung zur anwendung in den atemwegen
WO1993025198A1 (en) 1992-06-12 1993-12-23 Teijin Limited Ultrafine powder for inhalation and production thereof
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
BR9405798A (pt) * 1993-02-22 1995-12-12 Vivorx Pharmaceuticals Inc Métodos para liberação in vivo de material biológico e composições úteis dos mesmos
US5547175A (en) 1993-03-29 1996-08-20 Quad/Tech, Inc. Apparatus and method for preparing mail products
US5445367A (en) 1993-04-19 1995-08-29 Long; John A. System and method for preparing letters for mailing
NL9300979A (nl) 1993-06-07 1995-01-02 Hadewe Bv Werkwijze voor het verwerken van vellen in een postverwerkingssysteem alsmede een postverwerkingssysteem voor het toepassen van die werkwijze en een postverwerkingsinrichting van dat systeem.
EP0711179B2 (de) * 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilisierte mikrogasblaeschen-zusammensetzungen für echografie
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
US5955108A (en) 1994-12-16 1999-09-21 Quadrant Healthcare (Uk) Limited Cross-linked microparticles and their use as therapeutic vehicles
DE19533444A1 (de) 1995-03-08 1996-09-12 Boewe Systec Ag System zum Zusammenführen und Verbinden von Kunststoffkarten und bedruckten Kartenträgern
JP3281895B2 (ja) 1996-02-08 2002-05-13 プリンサーター コーポレイション 郵便物取扱システム及びその制御方法
GB9610830D0 (en) * 1996-05-23 1996-07-31 Andaris Ltd Use of hollow microcapsules
US5726897A (en) 1996-07-17 1998-03-10 United States Computer Services Mail assembly system and method
US6017310A (en) 1996-09-07 2000-01-25 Andaris Limited Use of hollow microcapsules
EP0949932A1 (de) 1996-10-19 1999-10-20 Quadrant Healthcare (UK) Limited Verwendung von mikrokohlkugeln zur diagnose und therapie
US6068600A (en) * 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US6202005B1 (en) * 1999-02-05 2001-03-13 First Data Corporation System for selectively printing messages and adding inserts to merchant statements

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GB2302650A (en) 1997-01-29
US6344182B1 (en) 2002-02-05
GB9616116D0 (en) 1996-09-11
EP0663840B1 (de) 2003-12-10
GB2286122A (en) 1995-08-09
US6939530B2 (en) 2005-09-06
DE69333345T2 (de) 2004-10-07
GB2302650B (en) 1997-04-09
US5957848A (en) 1999-09-28
HK1007959A1 (en) 1999-04-30
GB2286122B (en) 1997-04-09
DE69333345D1 (de) 2004-01-22
EP1226832A3 (de) 2004-01-02
ATE451127T1 (de) 2009-12-15
GB9507191D0 (en) 1995-05-31
EP1226832A2 (de) 2002-07-31
ATE255911T1 (de) 2003-12-15
EP1226832B1 (de) 2009-12-09
HK1007958A1 (en) 1999-04-30
ES2214477T3 (es) 2004-09-16
US6416741B1 (en) 2002-07-09
JPH08505366A (ja) 1996-06-11
DK0663840T3 (da) 2004-03-29
JP2006273874A (ja) 2006-10-12
HK1007960A1 (en) 1999-04-30
WO1994008627A1 (en) 1994-04-28
GB2302649A (en) 1997-01-29
CA2146783A1 (en) 1994-04-28
CA2146783C (en) 2009-05-26
GB2302649B (en) 1997-04-09
GB9616117D0 (en) 1996-09-11
US20050238586A1 (en) 2005-10-27
US6348186B1 (en) 2002-02-19
EP0663840A1 (de) 1995-07-26
ES2356372T3 (es) 2011-04-07
GB9221329D0 (en) 1992-11-25
US20030133876A1 (en) 2003-07-17
US6015546A (en) 2000-01-18

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