DE69411898D1 - Neue antikoagulant-cofaktor aktivität - Google Patents

Neue antikoagulant-cofaktor aktivität

Info

Publication number
DE69411898D1
DE69411898D1 DE69411898T DE69411898T DE69411898D1 DE 69411898 D1 DE69411898 D1 DE 69411898D1 DE 69411898 T DE69411898 T DE 69411898T DE 69411898 T DE69411898 T DE 69411898T DE 69411898 D1 DE69411898 D1 DE 69411898D1
Authority
DE
Germany
Prior art keywords
activity
apc
protein
component
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69411898T
Other languages
English (en)
Other versions
DE69411898T3 (de
DE69411898T2 (de
Inventor
Bjoern Dahlbaeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
T.A.C. THROMBOSIS AND COAGULATION AB, MALMOE, SE
Original Assignee
Bjoern Dahlbaeck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26661641&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69411898(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from SE9300300A external-priority patent/SE9300300D0/xx
Priority claimed from SE9302457A external-priority patent/SE9302457D0/xx
Application filed by Bjoern Dahlbaeck filed Critical Bjoern Dahlbaeck
Application granted granted Critical
Publication of DE69411898D1 publication Critical patent/DE69411898D1/de
Publication of DE69411898T2 publication Critical patent/DE69411898T2/de
Publication of DE69411898T3 publication Critical patent/DE69411898T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96461—Protein C (3.4.21.69)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96463—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
DE69411898T 1993-01-29 1994-01-28 Neue antikoagulant-cofaktor aktivität Expired - Lifetime DE69411898T3 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9300300 1993-01-29
SE9300300A SE9300300D0 (sv) 1993-01-29 1993-01-29 A novel anticoagulant entity, antibodies reacting specifically with the entity, and diagnostic and therapeutic used of the entity
SE9302457A SE9302457D0 (sv) 1993-07-20 1993-07-20 A novel anticoagulant entity, antibodies reacting specifically with the enety, and diagnostic and therapeutic uses of the entity
SE9302457 1993-07-20
PCT/SE1994/000070 WO1994017415A1 (en) 1993-01-29 1994-01-28 Novel anticoagulant cofactor activity

Publications (3)

Publication Number Publication Date
DE69411898D1 true DE69411898D1 (de) 1998-08-27
DE69411898T2 DE69411898T2 (de) 1998-12-17
DE69411898T3 DE69411898T3 (de) 2004-07-08

Family

ID=26661641

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69411898T Expired - Lifetime DE69411898T3 (de) 1993-01-29 1994-01-28 Neue antikoagulant-cofaktor aktivität

Country Status (17)

Country Link
US (2) US7169572B1 (de)
EP (1) EP0690991B2 (de)
JP (1) JPH08506181A (de)
AT (1) ATE168781T1 (de)
AU (1) AU690535B2 (de)
BR (1) BR9406223A (de)
CA (1) CA2154080C (de)
CZ (1) CZ184995A3 (de)
DE (1) DE69411898T3 (de)
DK (1) DK0690991T4 (de)
ES (1) ES2119165T5 (de)
FI (1) FI953565A (de)
GR (1) GR3027697T3 (de)
HU (1) HUT72191A (de)
NZ (1) NZ261190A (de)
PL (1) PL181102B1 (de)
WO (1) WO1994017415A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ184995A3 (en) * 1993-01-29 1996-03-13 Bjorn Dahlback Novel anticoagulative cofactor activity
AU690644B2 (en) * 1994-02-14 1998-04-30 Rijksuniversiteit Leiden A method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein C
DE4418635C2 (de) * 1994-05-27 1997-07-24 Immuno Ag Pharmazeutische Zusammensetzung zur Vorbeugung und Behandlung von Blutgerinnungsstörungen
DE4439756C2 (de) * 1994-11-09 2002-07-18 Dade Behring Marburg Gmbh Kalibrator zur Verwendung in Testverfahren zum Nachweis eines defekten Gerinnungsfaktors V
ATE198772T1 (de) * 1994-11-10 2001-02-15 Dade Behring Marburg Gmbh Verfahren zum spezifischen nachweis eines aktivierten gerinnungsfaktors v mit einer erhöhten stabilität gegenüber aktiviertem protein c
US6867045B1 (en) * 1994-11-14 2005-03-15 The Scripps Research Institute Method for diagnosis of thrombotic disorders
DE69520725T3 (de) * 1994-12-23 2005-11-17 Diagnostic Reagents Ltd., Thame Verfahren zur Diagnose von Blutgerinnungsstörungen
US5874256A (en) * 1995-06-06 1999-02-23 Rijks Universiteit Leiden Method for diagnosing an increased risk for thrombosis or a genetic defect causing thrombosis and kit for use with the same
US5863896A (en) * 1995-11-09 1999-01-26 Immuno Ag Evaluation of substances for altering and for increasing APC response
US5766869A (en) * 1995-11-30 1998-06-16 Ahs Hospital Corp. Factor V ratio blood test for susceptibility to thromboembolism
DE19634312A1 (de) * 1996-08-24 1998-02-26 Behringwerke Ag Verfahren zur Herstellung von Faktor V-Mangelplasma und ein so erhaltenes Mangelplasma
JP2002514433A (ja) * 1998-05-14 2002-05-21 バッテル メモリアル インスティテュート トランスジェニック植物由来ヒト凝血因子
FR2778923B1 (fr) * 1998-05-22 2000-08-18 Stago Diagnostica Compositions utiles comme controle pathologique dans une methode de detection d'une resistance a la proteine c activee, procede de preparation de ces compositions et utilisation dans ladite methode de detection
JP4377207B2 (ja) 2003-11-28 2009-12-02 シスメックス株式会社 血液凝固時間測定方法および血液凝固時間測定用試薬
EP2091564A4 (de) * 2006-10-16 2010-09-01 Novelmed Therapeutics Inc Verfahren zur gerinnungsverhinderung mit antikörpern gegen den menschlichen antifaktor va sowie anwendung davon
JP6962338B2 (ja) * 2017-01-06 2021-11-05 ソニーグループ株式会社 血液凝固系解析装置、血液凝固系解析システム、血液凝固系解析方法、及び血液凝固系解析用プログラム、並びに、出血量予測装置、出血量予測システム、出血量予測方法、及び出血量予測用プログラム

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3330699A1 (de) 1983-08-25 1985-03-07 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gleichzeitigen bestimmung von fibrinogen und fibrinogen-spaltprodukten im plasma
JPS60241900A (ja) 1984-05-16 1985-11-30 Nitto Boseki Co Ltd 新規な第Ｘａ因子活性測定用基質
DE3516579A1 (de) 1984-11-19 1986-05-22 Boehringer Mannheim Gmbh, 6800 Mannheim Gerinnungstest auf teststreifen
US4849403A (en) 1985-05-29 1989-07-18 Pentapharm Ag Protein C activator, methods of preparation and use thereof
DE3536903A1 (de) 1985-10-16 1987-04-16 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung von protein c
DE3607559A1 (de) 1986-03-07 1987-09-10 Boehringer Mannheim Gmbh Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet
US5200322A (en) * 1986-09-19 1993-04-06 Nippon Zoki Pharmaceutical Co., Ltd. Method for assaying protein C and measuring kit for the same
CA1339946C (en) 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
US5472850A (en) 1991-04-10 1995-12-05 Oklahoma Medical Research Foundation Quantitative clotting assay for activated factor VII
US5055412A (en) 1989-03-21 1991-10-08 Proksch Gary J Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same
IT1230744B (it) * 1989-07-07 1991-10-29 Instrumentation Lab Spa Metodo per la determinazione della attivita' funzionale della proteina s nel plasma umano.
WO1991001383A1 (en) 1989-07-14 1991-02-07 Michigan State University Method for diagnosing blood clotting disorders
SE464135B (sv) 1989-07-14 1991-03-11 Kabivitrum Ab Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov
US5051357A (en) 1989-07-14 1991-09-24 Board Of Trustees Operating Michigan State University Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor
US5169786A (en) 1989-12-19 1992-12-08 Ortho Diagnostic Systems, Inc. Method of determining levels of extrinsic and intrinsic clotting factors and protein c
US5314695A (en) 1990-11-13 1994-05-24 Corvas International, Inc. Tissue factor based prothrombin time reagent
AT395597B (de) 1991-01-25 1993-01-25 Immuno Ag Reagens zur bestimmung von faktor viii-aktivitaet
US5716795A (en) * 1991-10-04 1998-02-10 Matschiner; John T. Thrombomodulin-based coagulometric assay of the protein C system
AU2870992A (en) * 1991-10-04 1993-05-03 Board Of Regents Of The University Of Nebraska, The A soluble thrombomodulin-based one-stage assay for vitamin k-dependent coagulation-inhibiting proteins
SE470274B (sv) 1991-11-13 1993-12-20 Bjoern Dahlbaeck Användning av en in vitro-metod för diagnos av blodkoagulationssjukdomar
DK0608235T4 (da) 1991-11-13 2005-05-30 A C Thrombosis And Coagulati T Fremgangsmåde til diagnose af blodkoagulationssygdomme
US5308756A (en) * 1991-11-20 1994-05-03 Baxter Diagnostics Inc. Protein S chromogenic assay
CZ184995A3 (en) * 1993-01-29 1996-03-13 Bjorn Dahlback Novel anticoagulative cofactor activity
CA2137041C (en) * 1993-12-03 2003-06-10 Katalin Varadi Assay for determining sensitivity to activated protein c
DE4427785A1 (de) * 1994-08-08 1996-02-15 Behringwerke Ag Verfahren zum Nachweis von Störungen des Protein C/Protein S-Systems
DE4439756C2 (de) * 1994-11-09 2002-07-18 Dade Behring Marburg Gmbh Kalibrator zur Verwendung in Testverfahren zum Nachweis eines defekten Gerinnungsfaktors V
US5705395A (en) * 1994-11-14 1998-01-06 The Scripps Research Institute Method for diagnosis of thrombotic disorders
US5780255A (en) * 1995-06-09 1998-07-14 Instrumentation Laboratory, S.P.A. Protein C pathway screening test
US20030143759A1 (en) 1995-10-20 2003-07-31 Bjorn Dahlback Assays for determining anticoagulant cofactor activity
US5766869A (en) * 1995-11-30 1998-06-16 Ahs Hospital Corp. Factor V ratio blood test for susceptibility to thromboembolism

Also Published As

Publication number Publication date
US7169572B1 (en) 2007-01-30
EP0690991A1 (de) 1996-01-10
NZ261190A (en) 1997-12-19
WO1994017415A1 (en) 1994-08-04
ES2119165T5 (es) 2004-07-01
AU690535B2 (en) 1998-04-30
AU5982794A (en) 1994-08-15
HU9502190D0 (en) 1995-09-28
EP0690991B1 (de) 1998-07-22
CZ184995A3 (en) 1996-03-13
CA2154080A1 (en) 1994-08-04
FI953565A0 (fi) 1995-07-26
BR9406223A (pt) 1996-01-09
FI953565A (fi) 1995-07-26
HUT72191A (en) 1996-03-28
ES2119165T3 (es) 1998-10-01
DK0690991T4 (da) 2004-02-16
PL310050A1 (en) 1995-11-13
DE69411898T3 (de) 2004-07-08
EP0690991B2 (de) 2004-01-14
DE69411898T2 (de) 1998-12-17
JPH08506181A (ja) 1996-07-02
US20070212743A1 (en) 2007-09-13
CA2154080C (en) 2006-03-21
DK0690991T3 (da) 1999-02-01
GR3027697T3 (en) 1998-11-30
ATE168781T1 (de) 1998-08-15
PL181102B1 (pl) 2001-05-31

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: T.A.C. THROMBOSIS AND COAGULATION AB, MALMOE, SE

8366 Restricted maintained after opposition proceedings
8310 Action for declaration of annulment
8328 Change in the person/name/address of the agent

Representative=s name: TER MEER STEINMEISTER & PARTNER GBR PATENTANWAELTE,

8313 Request for invalidation rejected/withdrawn