DE69415543T2 - Neue verfahren zur progesteronabgabe - Google Patents

Neue verfahren zur progesteronabgabe

Info

Publication number
DE69415543T2
DE69415543T2 DE69415543T DE69415543T DE69415543T2 DE 69415543 T2 DE69415543 T2 DE 69415543T2 DE 69415543 T DE69415543 T DE 69415543T DE 69415543 T DE69415543 T DE 69415543T DE 69415543 T2 DE69415543 T2 DE 69415543T2
Authority
DE
Germany
Prior art keywords
progesterone
serum
low levels
delivery procedure
serum progesterone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69415543T
Other languages
English (en)
Other versions
DE69415543D1 (de
Inventor
William Bologna
Howard Levine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia Laboratories Bermuda Ltd
Original Assignee
Columbia Laboratories Bermuda Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22402302&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69415543(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Columbia Laboratories Bermuda Ltd filed Critical Columbia Laboratories Bermuda Ltd
Application granted granted Critical
Publication of DE69415543D1 publication Critical patent/DE69415543D1/de
Publication of DE69415543T2 publication Critical patent/DE69415543T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
DE69415543T 1993-09-15 1994-09-13 Neue verfahren zur progesteronabgabe Expired - Lifetime DE69415543T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/122,371 US5543150A (en) 1993-09-15 1993-09-15 Method of progesterone delivery and affect thereof
PCT/US1994/010270 WO1995007699A1 (en) 1993-09-15 1994-09-13 Novel method of progesterone delivery and affect thereof

Publications (2)

Publication Number Publication Date
DE69415543D1 DE69415543D1 (de) 1999-02-04
DE69415543T2 true DE69415543T2 (de) 1999-06-17

Family

ID=22402302

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69415543T Expired - Lifetime DE69415543T2 (de) 1993-09-15 1994-09-13 Neue verfahren zur progesteronabgabe

Country Status (27)

Country Link
US (1) US5543150A (de)
EP (1) EP0719146B1 (de)
JP (1) JP3143474B2 (de)
KR (1) KR100278553B1 (de)
AT (1) ATE174796T1 (de)
BR (1) BR9407475A (de)
CA (1) CA2171939C (de)
CO (1) CO4290332A1 (de)
DE (1) DE69415543T2 (de)
DK (1) DK0719146T3 (de)
ES (1) ES2126783T3 (de)
FI (1) FI115444B (de)
GR (1) GR3029314T3 (de)
HU (1) HU221583B (de)
IL (1) IL110972A (de)
LT (1) LT4072B (de)
LV (1) LV11527B (de)
MA (1) MA23329A1 (de)
MY (1) MY111484A (de)
NO (1) NO308585B1 (de)
NZ (1) NZ273816A (de)
PE (1) PE50795A1 (de)
PH (1) PH30813A (de)
RU (1) RU2148393C1 (de)
UA (1) UA37244C2 (de)
WO (1) WO1995007699A1 (de)
ZA (1) ZA947073B (de)

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US6056972A (en) * 1997-02-26 2000-05-02 Dimera, Llc Method for reducing coronary artery reactivity
US6602487B1 (en) 1997-02-26 2003-08-05 Dimera Incorporated Methods and tests for producing and for inhibiting coronary artery vasospasms
EP1356806A1 (de) * 1997-09-12 2003-10-29 Columbia Laboratories (Bermuda) Limited Arzneimittel zur Behandlung von Dysmenorrhöe und verfrühten Wehen
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US20040234606A1 (en) * 1997-09-12 2004-11-25 Levine Howard L. Localized vaginal delivery without detrimental blood levels
DE69819748T2 (de) * 1997-09-12 2004-09-30 Columbia Laboratories (Bermuda) Ltd. Arzneimittel zur behandlung von dysmenorrhöe und verfrühten wehen
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US6248358B1 (en) * 1998-08-25 2001-06-19 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets and methods of making and using the same
JP2001519381A (ja) * 1997-10-10 2001-10-23 インペリアル・カレッジ・イノベイションズ・リミテッド 子宮収縮管理のためのｃｓａｉｄｔｍ化合物の使用
US6306914B1 (en) 1997-10-21 2001-10-23 Columbia Laboratories, Inc. Progestin therapy for maintaining amenorrhea
AU4406899A (en) * 1998-05-20 1999-12-06 Bent Formby Progesterone treatment of cancer
IL127129A (en) * 1998-11-18 2004-06-01 Ferring Bv Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared
US20070178139A1 (en) * 1998-11-18 2007-08-02 Yankov Vladimir I Vaginally administratable progesterone-containing tablets and method for preparing same
US6479045B2 (en) 1999-12-22 2002-11-12 Columbia Laboratories, Inc. Vaginal pH buffering for preventing miscarriage and premature labor, by treating or preventing bacterial vaginosis
US6544553B1 (en) 1999-12-28 2003-04-08 Watson Pharmaceuticals, Inc. Dosage forms and methods for oral delivery of progesterone
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US7544348B2 (en) * 2001-02-15 2009-06-09 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
DK1363600T3 (da) * 2001-02-15 2009-01-26 Access Pharma Inc Flydende formuleringer til forebyggelse og behandling af mucosale sygdomme og lidelser
US20060073174A1 (en) * 2001-08-16 2006-04-06 Access Pharmaceuticals, Inc. Adherent and erodible film to treat a moist surface of a body tissue
US6585997B2 (en) 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US8425892B2 (en) 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
US20030114394A1 (en) * 2001-10-29 2003-06-19 Levine Howard L. Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US20080182841A1 (en) * 2001-10-29 2008-07-31 Levine Howard L Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US7709026B2 (en) 2001-10-29 2010-05-04 Columbia Laboratories, Inc. Low concentration of peroxide for treating or preventing vaginal infections
US7572780B2 (en) 2003-01-21 2009-08-11 Dimera, Incorporated Method and kit for reducing the symptoms of peripheral vascular disease
US7833545B2 (en) * 2003-04-29 2010-11-16 The General Hospital Corporation Methods and devices for the sustained release of multiple drugs
ES2237298B1 (es) 2003-07-16 2006-11-01 Italfarmaco, S.A. Formulaciones mucoadhesivas semisolidas.
BRPI0413200A (pt) 2003-09-03 2006-10-03 Miscon Trading S A método para tratamento de endometriose
UA90095C2 (en) * 2003-09-03 2010-04-12 Мискон Трейдинг С.А. Method for the treatment of endometriosis
WO2006138686A1 (en) * 2005-06-16 2006-12-28 Warner Chilcott Company, Inc. Estrogen compositions for vaginal administration
CA2612456C (en) * 2005-06-16 2017-06-06 Warner Chilcott Company, Inc. Gel compositions for topical administration
WO2007143607A2 (en) * 2006-06-02 2007-12-13 Pear Tree Women's Health Care Method of treating atrophic vaginitis
US8828981B2 (en) 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
ES2310968B1 (es) 2007-06-25 2010-02-08 Italfarmaco, S.A. Uso de estriol en bajas dosis.
JP2010539245A (ja) * 2007-09-14 2010-12-16 日東電工株式会社 薬物担体
GB0723882D0 (en) * 2007-12-07 2008-01-23 Univ Leicester Methods for the detection of a threatened miscarriage
NZ611268A (en) * 2008-02-04 2015-03-27 Teva Women’S Health Inc Monolithic intravaginal rings comprising progesterone and methods of making and uses thereof
US9107696B2 (en) 2008-08-06 2015-08-18 Emory University Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus
ES2344673B1 (es) 2008-08-07 2011-05-03 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral.
US8421747B2 (en) 2008-09-24 2013-04-16 Microsoft Corporation Object detection and user settings
ES2344675B1 (es) 2008-12-19 2011-04-28 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular.
CN107260745A (zh) * 2010-03-22 2017-10-20 利普生物药剂公司 用于抗孕酮的非毒性递送的组合物和方法
US9375437B2 (en) 2010-06-18 2016-06-28 Lipocine Inc. Progesterone containing oral dosage forms and kits
US8435972B2 (en) 2010-09-02 2013-05-07 Emory University Method for the treatment of central nervous system cancers and compositions related thereto
JP6010120B2 (ja) * 2011-07-15 2016-10-19 ウニベルシテイト ヘント 膣内送達システム
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
CA2856520C (en) 2011-11-23 2021-04-06 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
EP2806742B1 (de) * 2012-01-26 2019-03-27 TherapeuticsMD, Inc. Transdermale hormonersatztherapien
SG11201407397WA (en) 2012-05-31 2014-12-30 Repros Therapeutics Inc Formulations and methods for vaginal delivery of antiprogestins
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
CN104755087A (zh) 2012-11-02 2015-07-01 利普生物药剂公司 治疗孕酮依赖性病况的方法和组合物
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN103239389A (zh) * 2013-06-03 2013-08-14 南京泽恒医药技术开发有限公司 一种治疗先兆性流产的黄体酮缓释凝胶的制备方法
MX2016014281A (es) 2014-05-22 2017-02-22 Therapeuticsmd Inc Formulaciones y terapias de reemplazo de combinación de hormonas naturales.
RU2016141135A (ru) 2014-07-29 2018-08-28 Терапьютиксмд, Инк. Трансдермальный крем
US20170035781A1 (en) 2015-06-22 2017-02-09 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
AU2018287513A1 (en) * 2017-06-22 2020-02-06 Viramal Limited Compositions for drug delivery and methods of use thereof
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

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Also Published As

Publication number Publication date
PE50795A1 (es) 1996-01-19
EP0719146B1 (de) 1998-12-23
DK0719146T3 (da) 1999-08-23
MA23329A1 (fr) 1995-04-01
HU221583B (hu) 2002-11-28
KR100278553B1 (ko) 2001-01-15
NO961044L (no) 1996-05-14
ATE174796T1 (de) 1999-01-15
WO1995007699A1 (en) 1995-03-23
RU2148393C1 (ru) 2000-05-10
CA2171939C (en) 2002-01-01
UA37244C2 (uk) 2001-05-15
CA2171939A1 (en) 1995-03-23
JP3143474B2 (ja) 2001-03-07
HU9600669D0 (en) 1996-05-28
FI961221A (fi) 1996-05-14
LV11527B (en) 1997-02-20
MY111484A (en) 2000-06-30
NO961044D0 (no) 1996-03-14
JPH09502724A (ja) 1997-03-18
ZA947073B (en) 1995-05-02
HUT76824A (en) 1997-11-28
ES2126783T3 (es) 1999-04-01
FI115444B (fi) 2005-05-13
PH30813A (en) 1997-10-17
IL110972A (en) 1998-03-10
FI961221A0 (fi) 1996-03-15
LT4072B (en) 1996-11-25
US5543150A (en) 1996-08-06
LV11527A (lv) 1996-10-20
LT96027A (en) 1996-07-25
EP0719146A1 (de) 1996-07-03
NZ273816A (en) 2007-09-28
IL110972A0 (en) 1994-11-28
GR3029314T3 (en) 1999-05-28
CO4290332A1 (es) 1996-04-17
BR9407475A (pt) 1996-11-12
DE69415543D1 (de) 1999-02-04
NO308585B1 (no) 2000-10-02
AU7726194A (en) 1995-04-03
AU689133B2 (en) 1998-03-26

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Legal Events

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8364 No opposition during term of opposition