DE69416166T2 - Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen - Google Patents
Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinenInfo
- Publication number
- DE69416166T2 DE69416166T2 DE69416166T DE69416166T DE69416166T2 DE 69416166 T2 DE69416166 T2 DE 69416166T2 DE 69416166 T DE69416166 T DE 69416166T DE 69416166 T DE69416166 T DE 69416166T DE 69416166 T2 DE69416166 T2 DE 69416166T2
- Authority
- DE
- Germany
- Prior art keywords
- sialinic
- regulating
- derivatives
- recombinant glycoproteins
- cell culture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14829893A | 1993-11-05 | 1993-11-05 | |
PCT/US1994/012420 WO1995012684A1 (en) | 1993-11-05 | 1994-10-28 | Methods for controlling sialic acid derivatives in recombinant glycoproteins |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69416166D1 DE69416166D1 (de) | 1999-03-04 |
DE69416166T2 true DE69416166T2 (de) | 1999-08-19 |
Family
ID=22525160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69416166T Expired - Lifetime DE69416166T2 (de) | 1993-11-05 | 1994-10-28 | Verfahren zur regulierung von sialinsaeurederivaten in rekombinanten glykoproteinen |
Country Status (11)
Country | Link |
---|---|
US (1) | US5459031A (de) |
EP (1) | EP0734450B1 (de) |
AT (1) | ATE175999T1 (de) |
AU (1) | AU8095494A (de) |
CA (1) | CA2183552C (de) |
DE (1) | DE69416166T2 (de) |
DK (1) | DK0734450T3 (de) |
ES (1) | ES2126793T3 (de) |
GR (1) | GR3029499T3 (de) |
HK (1) | HK1008835A1 (de) |
WO (1) | WO1995012684A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
DE69315836T2 (de) * | 1992-06-10 | 1998-04-09 | Fujisawa Pharmaceutical Co | Pyrazolpyridine für die behandlung der anämie |
US6573055B2 (en) * | 1997-04-21 | 2003-06-03 | Glycozyme, Inc. | Determination of recombinant glycosylated proteins and peptides in biological fluids |
AU744086B2 (en) * | 1997-12-03 | 2002-02-14 | Roche Diagnostics Gmbh | Erythropoietin with high specific activity |
EP1276849A4 (de) | 2000-04-12 | 2004-06-09 | Human Genome Sciences Inc | Albumin fusionsproteine |
US20040214273A1 (en) | 2001-01-19 | 2004-10-28 | Kazuhito Fujiyama | Method for secretory production of glycoprotein having human-type sugar chain using plant cell |
US20030096281A1 (en) * | 2001-09-14 | 2003-05-22 | Ganesh Venkataraman | Methods of making glycomolecules with enhanced activities and uses thereof |
EP2277889B1 (de) | 2001-12-21 | 2014-07-09 | Human Genome Sciences, Inc. | Fusionsproteine von Albumin und Interferon beta |
CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
ES2564790T5 (es) | 2005-12-08 | 2023-08-25 | Amgen Inc | Producción mejorada de glicoproteínas usando manganeso |
MX2009011109A (es) | 2007-04-17 | 2009-12-01 | Plant Res Int Bv | Glicosilación tipo mamífera en plantas para la expresión de glicosil-transferasas no mamíferas. |
EP2325296A1 (de) | 2009-11-20 | 2011-05-25 | LEK Pharmaceuticals d.d. | Herstellung von Glykoproteinen mit niedrigem N-Glykolylneuraminsäure-Gehalt (Neu5Gc-Gehalt) |
BR112012025645A2 (pt) | 2010-04-07 | 2017-12-12 | Momenta Pharmaceuticals Inc | glicanos de alta manose. |
US9170249B2 (en) | 2011-03-12 | 2015-10-27 | Momenta Pharmaceuticals, Inc. | N-acetylhexosamine-containing N-glycans in glycoprotein products |
EP2511293A1 (de) * | 2011-04-13 | 2012-10-17 | LEK Pharmaceuticals d.d. | Verfahren zur Steuerung der Hauptkomplex-N-Glycan-Strukturen und der sauren Varianten und Variabilität in Bioprozessen, die rekombinante Proteine produzieren |
EP2856159A4 (de) | 2012-06-01 | 2016-04-13 | Momenta Pharmaceuticals Inc | Verfahren im zusammenhang mit denosumab |
WO2014149067A1 (en) | 2013-03-15 | 2014-09-25 | Momenta Pharmaceuticals, Inc. | Methods related to ctla4-fc fusion proteins |
WO2014186310A1 (en) | 2013-05-13 | 2014-11-20 | Momenta Pharmaceuticals, Inc. | Methods for the treatment of neurodegeneration |
US20160257754A1 (en) | 2013-10-16 | 2016-09-08 | Momenta Pharmaceuticals Inc. | Sialylated glycoproteins |
WO2023086793A1 (en) | 2021-11-09 | 2023-05-19 | Amgen Inc. | Production of therapeutic proteins |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
US4954437A (en) * | 1986-09-15 | 1990-09-04 | Integrated Genetics, Inc. | Cell encoding recombinant human erythropoietin |
US5047335A (en) * | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
GEP20002145B (en) * | 1989-10-16 | 2000-06-25 | Amgen Inc Us | Stem Cell Factor |
US5272070A (en) * | 1991-03-08 | 1993-12-21 | Board Of Regents, The University Of Texas System | Method for the preparation of cell lines producing Man3 GlcNac 2 asparagine-linked gylcans and cell lines produced thereby |
-
1994
- 1994-06-17 US US08/261,697 patent/US5459031A/en not_active Expired - Lifetime
- 1994-10-28 AU AU80954/94A patent/AU8095494A/en not_active Abandoned
- 1994-10-28 ES ES94932105T patent/ES2126793T3/es not_active Expired - Lifetime
- 1994-10-28 DE DE69416166T patent/DE69416166T2/de not_active Expired - Lifetime
- 1994-10-28 DK DK94932105T patent/DK0734450T3/da active
- 1994-10-28 CA CA002183552A patent/CA2183552C/en not_active Expired - Lifetime
- 1994-10-28 AT AT94932105T patent/ATE175999T1/de not_active IP Right Cessation
- 1994-10-28 WO PCT/US1994/012420 patent/WO1995012684A1/en active IP Right Grant
- 1994-10-28 EP EP94932105A patent/EP0734450B1/de not_active Expired - Lifetime
-
1998
- 1998-07-31 HK HK98109571A patent/HK1008835A1/xx not_active IP Right Cessation
-
1999
- 1999-02-26 GR GR990400596T patent/GR3029499T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5459031A (en) | 1995-10-17 |
ATE175999T1 (de) | 1999-02-15 |
GR3029499T3 (en) | 1999-05-28 |
WO1995012684A1 (en) | 1995-05-11 |
DK0734450T3 (da) | 1999-09-13 |
DE69416166D1 (de) | 1999-03-04 |
HK1008835A1 (en) | 1999-05-21 |
ES2126793T3 (es) | 1999-04-01 |
AU8095494A (en) | 1995-05-23 |
EP0734450A1 (de) | 1996-10-02 |
CA2183552C (en) | 2000-02-08 |
EP0734450B1 (de) | 1999-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |