DE69417481D1 - Überzogene Mikropartikel mit verbesserter Arzneistoffabsorption - Google Patents

Überzogene Mikropartikel mit verbesserter Arzneistoffabsorption

Info

Publication number
DE69417481D1
DE69417481D1 DE69417481T DE69417481T DE69417481D1 DE 69417481 D1 DE69417481 D1 DE 69417481D1 DE 69417481 T DE69417481 T DE 69417481T DE 69417481 T DE69417481 T DE 69417481T DE 69417481 D1 DE69417481 D1 DE 69417481D1
Authority
DE
Germany
Prior art keywords
solution
drug absorption
improved drug
coated microparticles
millispheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69417481T
Other languages
English (en)
Other versions
DE69417481T2 (de
Inventor
Los Santos Garces Garces Jo De
Munoz Angel Bonilla
Anton Jose Maria Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GP Pharm SA
Original Assignee
Lipotec SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipotec SA filed Critical Lipotec SA
Publication of DE69417481D1 publication Critical patent/DE69417481D1/de
Application granted granted Critical
Publication of DE69417481T2 publication Critical patent/DE69417481T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
DE69417481T 1993-07-21 1994-07-19 Überzogene Mikropartikel mit verbesserter Arzneistoffabsorption Expired - Lifetime DE69417481T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09301637A ES2068762B1 (es) 1993-07-21 1993-07-21 Un nuevo preparado farmaceutico para mejorar la biodisponibilidad de drogas de dificil absorcion y procedimiento para su obtencion.

Publications (2)

Publication Number Publication Date
DE69417481D1 true DE69417481D1 (de) 1999-05-06
DE69417481T2 DE69417481T2 (de) 1999-11-25

Family

ID=8282628

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69417481T Expired - Lifetime DE69417481T2 (de) 1993-07-21 1994-07-19 Überzogene Mikropartikel mit verbesserter Arzneistoffabsorption

Country Status (7)

Country Link
US (1) US5736161A (de)
EP (1) EP0635261B1 (de)
JP (1) JP4480801B2 (de)
AT (1) ATE178205T1 (de)
DE (1) DE69417481T2 (de)
DK (1) DK0635261T3 (de)
ES (1) ES2068762B1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
US5938990A (en) * 1994-07-01 1999-08-17 Roche Vitamins Inc. Encapsulation of oleophilic substances and compositions produced thereby
US6992107B1 (en) 1995-03-10 2006-01-31 Photocure Asa Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
AU717113B2 (en) 1995-11-09 2000-03-16 Health Protection Agency Microencapsulated DNA for vaccination and gene therapy
US5783567A (en) * 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
WO1998048626A1 (en) * 1997-04-30 1998-11-05 Emory University Methods and compositions for administering dna to mucosal surfaces
GB9710699D0 (en) 1997-05-24 1997-07-16 Danbiosyst Uk Gastro-retentive controlled release system
JP4272811B2 (ja) * 1997-09-05 2009-06-03 マルホ株式会社 関節内疾患治療用のナノカプセル製剤
US6090368A (en) * 1998-03-03 2000-07-18 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Pharmaceutical compositions for intranasal spray administration of ketorolac tromethamine
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
WO1999065531A1 (en) 1998-06-18 1999-12-23 Johns Hopkins University School Of Medicine Polymers for delivery of nucleic acids
US6916490B1 (en) 1998-07-23 2005-07-12 UAB Research Center Controlled release of bioactive substances
RU2236847C2 (ru) * 1998-11-02 2004-09-27 Илан Корпорейшн, Плк. Композиции в виде множества частиц с модифицированным высвобождением
US20080113025A1 (en) * 1998-11-02 2008-05-15 Elan Pharma International Limited Compositions comprising nanoparticulate naproxen and controlled release hydrocodone
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US7658938B2 (en) * 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
EP1080719A3 (de) * 1999-09-03 2001-04-25 Active Organics Inc. Verfahren zur Potenzierung der Wirksamkeit topischer Wirkstoffe durch Mono-acyl-(lyso)-glyceropholipide
WO2001028918A1 (en) 1999-10-19 2001-04-26 Cornell Research Foundation, Inc. Controlled release of doxorubicin
ES2162746B1 (es) * 1999-10-21 2003-02-16 Lipotec Sa Microcapsulas para la estabilizacion de productos cosmeticos, farmaceuticos o de alimentacion.
DK1225898T3 (da) * 1999-11-01 2003-09-15 Alcon Inc Farmaceutisk præparat indeholdende et fluorquinolonantibiotisk lægemiddel og xanthangummi
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DE10021894A1 (de) * 2000-05-05 2001-11-29 Ilias Papadopoulos Pharmazeutisches Präparat zur Diagnose und Behandlung der erektilen Dysfunktion
KR20020018566A (ko) * 2000-09-01 2002-03-08 액티브 올가닉스 인코포레이티드 모노-아실-(리소)-글리세롤인지질로 국소 활성의 효능을강화하는 방법 및 이의 용도
ITMI20010347A1 (it) * 2001-02-21 2002-08-21 Grisotech S A Complessi di immunoglobuline e polisaccaridi per assorbimento orale etrans-mucosale
US20030166282A1 (en) * 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
CN1652750A (zh) * 2002-04-03 2005-08-10 兰贝克赛实验室有限公司 红霉素a及其衍生物的味道掩蔽组合物
US7858607B2 (en) * 2003-03-14 2010-12-28 Mamchur Stephen A System for use by compounding pharmacists to produce hormone replacement medicine customized for each consumer
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
WO2005079752A2 (en) * 2004-02-11 2005-09-01 Rubicon Research Private Limited Controlled release pharmaceutical compositions with improved bioavailability
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
CA2612994A1 (en) * 2005-06-08 2006-12-08 Elan Pharma International Limited Nanoparticulate and controlled release compositions comprising cefditoren
US20060293236A1 (en) * 2005-06-23 2006-12-28 Prescott Albert G Injectable Osteogenic Formula and Method of Using Same
US20070082029A1 (en) * 2005-10-07 2007-04-12 Aimutis William R Fiber satiety compositions
US20070082030A1 (en) * 2005-10-07 2007-04-12 Aimutis William R Fiber satiety compositions
FR2897267A1 (fr) * 2006-02-16 2007-08-17 Flamel Technologies Sa Formes pharmaceutiques multimicroparticulaires pour administration per os
US20070218029A1 (en) * 2006-03-16 2007-09-20 Librizzi Joseph J High-deposition compositions and uses thereof
US20070224153A1 (en) * 2006-03-16 2007-09-27 Librizzi Joseph J High-deposition compositions and uses thereof
US20090280148A1 (en) * 2006-03-29 2009-11-12 Makiko Aimi Casein nanoparticle
CA2648594C (en) * 2006-04-07 2012-10-16 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
JP2009539862A (ja) * 2006-06-09 2009-11-19 メリオン リサーチ Iii リミテッド 強化剤を含む固体経口投与剤形
US20080085354A1 (en) * 2006-10-06 2008-04-10 Teresa Marie Paeschke Controlled hydration of hydrocolloids
US8344024B2 (en) * 2007-07-31 2013-01-01 Elc Management Llc Anhydrous cosmetic compositions containing resveratrol derivatives
US9295621B2 (en) * 2007-07-31 2016-03-29 Elc Management Llc Emulsion cosmetic compositions containing resveratrol derivatives and silicone surfactant
US8080583B2 (en) * 2007-07-31 2011-12-20 Elc Management Llc Emulsion cosmetic compositions containing resveratrol derivatives and linear or branched silicone
US20090035236A1 (en) * 2007-07-31 2009-02-05 Maes Daniel H Emulsion Cosmetic Compositions Containing Resveratrol Derivatives And An Oil Phase Structuring Agent
US20090035240A1 (en) * 2007-07-31 2009-02-05 Maes Daniel H Aqueous Based Cosmetic Compositions Containing Resveratrol Derivatives And An Aqueous Phase Structuring Agent
US20130079749A1 (en) * 2007-08-29 2013-03-28 Advanced Bionics, Llc Modular Drug Delivery System for Minimizing Trauma During and After Insertion of a Cochlear Lead
WO2009032896A2 (en) * 2007-09-08 2009-03-12 Elc Management Llc Resveratrol ferulate compounds, compositions containing the compounds, and methods of using the same
CA2718416C (en) * 2008-03-13 2018-01-02 Mallinckrodt Inc. Multi-function, foot-activated controller for imaging system
US20090280169A1 (en) * 2008-05-07 2009-11-12 Merrion Research Iii Limited Compositions of peptides and processes of preparation thereof
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
CA2751854A1 (en) * 2009-02-25 2010-09-02 Merrion Research Iii Limited Composition and drug delivery of bisphosphonates
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
JP2014501784A (ja) 2011-01-07 2014-01-23 メリオン・リサーチ・Iii・リミテッド 経口投与用の鉄の医薬組成物
WO2013139377A1 (en) 2012-03-20 2013-09-26 Laboratorios Bagó S.A. Method for producing enteric alginate microcapsules via ionic gelation containing diclofenac or one of the salts thereof and multiparticled pharmaceutical composition containing them
EA201591954A1 (ru) * 2013-04-12 2016-04-29 Вайом Байосайнсиз Пвт. Лтд. Композиция и состав противомикробных средств, способы их получения и способы лечения микробных инфекций
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
CN107205948B (zh) 2015-01-29 2021-12-14 诺和诺德股份有限公司 包含glp-1激动剂和肠溶衣的片剂
US9687475B1 (en) 2016-03-24 2017-06-27 Ezra Pharma Llc Extended release pharmaceutical formulations with controlled impurity levels
US9675585B1 (en) 2016-03-24 2017-06-13 Ezra Pharma Extended release pharmaceutical formulations
CA3078723A1 (en) 2016-11-28 2018-05-31 Nachiappan Chidambaram Oral testosterone undecanoate therapy
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
KR20220008824A (ko) 2019-04-17 2022-01-21 컴퍼스 패쓰파인더 리미티드 실로시빈으로 불안 장애, 두통 장애 및 섭식 장애를 치료하는 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA301777A (en) * 1930-07-08 Russell Bates David Preheater for boiler feed water
JPS6164701A (ja) * 1984-09-06 1986-04-03 Meito Sangyo Kk カチオン化デキストラン誘導体とポリウロン酸の高分子電解質錯体及びその利用
AU591248B2 (en) * 1986-03-27 1989-11-30 Kinaform Technology, Inc. Sustained-release pharaceutical preparation
DE3615043A1 (de) * 1986-05-03 1987-11-05 Hoechst Ag Verfahren zur verkapselung von biologisch aktivem material
EP0301777A1 (de) * 1987-07-28 1989-02-01 Queen's University At Kingston Multiple Membran-Mikroenkapselung
IT1230576B (it) * 1988-10-20 1991-10-28 Angeli Inst Spa Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
SE9002339L (sv) * 1990-07-04 1992-01-05 Kabi Pharmacia Ab Terapeutisk komposition och foerfarande foer dess framstaellning
US5215757A (en) * 1991-03-22 1993-06-01 The Procter & Gamble Company Encapsulated materials
IT1260505B (it) * 1992-06-01 1996-04-09 Poli Ind Chimica Spa Sistemi farmaceutici orali a cessione ritardata per il rilascio specifico nel colon

Also Published As

Publication number Publication date
DK0635261T3 (da) 1999-10-18
DE69417481T2 (de) 1999-11-25
JP4480801B2 (ja) 2010-06-16
EP0635261A1 (de) 1995-01-25
US5736161A (en) 1998-04-07
ATE178205T1 (de) 1999-04-15
ES2068762B1 (es) 1995-12-01
EP0635261B1 (de) 1999-03-31
JPH07145044A (ja) 1995-06-06
ES2068762A1 (es) 1995-04-16

Similar Documents

Publication Publication Date Title
DE69417481T2 (de) Überzogene Mikropartikel mit verbesserter Arzneistoffabsorption
CA2021574A1 (en) Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked
PT952822E (pt) Microparticulas de gelatina a e quitosano
DE69606028T2 (de) Taxal derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzung
DE69816951D1 (de) Zubereitung enthaltend Cefaclor oder Cephalexin mit modifizierter Freisetzungsmatrix
DE69031950D1 (de) Kleine partikeln enthaltende arzneistoffzusammensetzung
BR9608208A (pt) Composição de revestimento de pó para revestimento eletrotático de substrato farmacêuticos
FR2655266B1 (fr) Compositions pharmaceutiques a base de cimetidine.
AU6764390A (en) Pharmaceutical granules and drug dosage units made therefrom
YU31599A (sh) Brzo oslobadjajući i za ukus maskirajući farmaceutski oblik doze
DE3860967D1 (de) Arzneimittel in form stabiler suspendiermittel freier sucralfat-suspensionen.
DE59104870D1 (de) Orale Arzneiform und Überzugsmittel, enthaltend ein im Colon abbaubares Polysaccharid.
CA2212309A1 (en) Extended-release solid oral dosage forms of drugs having low solubility in water
GB2305606A (en) Drug delivery composition for the nasal administration of antiviral agents
CA2033418A1 (en) Pharmaceutical preparation for oral administration in fluid form
DK0519950T3 (da) Præparat
AU7855591A (en) Serotonin antagonist naphtosultam derivatives, their preparation and drugs containing same
JP2003508423A (ja) ナノゾールを含有する医薬製剤
JPH06256221A (ja) 徐放性組成物
JPS6479111A (en) Sustained release preparation and production thereof
FR2710268B1 (fr) Utilisation de beta-cyclodextrines partiellement méthylées comme promoteurs d'absorption dans la préparation de compositions pharmaceutiques pour l'administration transcutanée de principes actifs.
EP0676206A4 (de)
TH21049A (th) "การเตรียมสารปล่อยช่วยพยุงซึ่งย่อยสลายทางชีวได้เพื่อการรักษาโรคเยื่อหุ้มพันอักเสบ"
FR2657010B1 (fr) Composition pharmaceutique sous forme de suspension aqueuse stable a base de sucrafalte et d'une substance anti-acide ainsi que son procede de preparation.
RU97115541A (ru) Сбор "мономах" лекарственных растений, обладающий детоксицирующим действием

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R082 Change of representative

Ref document number: 635261

Country of ref document: EP

Representative=s name: RACKETTE PARTNERSCHAFT PATENTANWAELTE, DE

R081 Change of applicant/patentee

Ref document number: 635261

Country of ref document: EP

Owner name: GP-PHARM, S.A., ES

Free format text: FORMER OWNER: LIPOTEC, S.A., L'HOSPITALET DE LLOBREGAT, ES

Effective date: 20120727

Ref document number: 635261

Country of ref document: EP

Owner name: GP-PHARM, S.A., ES

Free format text: FORMER OWNER: GP PHARM S.A., BARCELONA, ES

Effective date: 20120830

R082 Change of representative

Ref document number: 635261

Country of ref document: EP

Representative=s name: RACKETTE PARTNERSCHAFT PATENTANWAELTE, DE

Effective date: 20120830

Ref document number: 635261

Country of ref document: EP

Representative=s name: RACKETTE PARTNERSCHAFT PATENTANWAELTE, DE

Effective date: 20120727