DE69423436D1 - An lipoprotein gebundene phospholipase a2, inhibitoren davon und deren verwendung für diagnose und therapie - Google Patents
An lipoprotein gebundene phospholipase a2, inhibitoren davon und deren verwendung für diagnose und therapieInfo
- Publication number
- DE69423436D1 DE69423436D1 DE69423436T DE69423436T DE69423436D1 DE 69423436 D1 DE69423436 D1 DE 69423436D1 DE 69423436 T DE69423436 T DE 69423436T DE 69423436 T DE69423436 T DE 69423436T DE 69423436 D1 DE69423436 D1 DE 69423436D1
- Authority
- DE
- Germany
- Prior art keywords
- phospholipase
- lipoprotein
- tied
- diagnosis
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/005—Enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/323—Arteriosclerosis, Stenosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939313144A GB9313144D0 (en) | 1993-06-25 | 1993-06-25 | Compounds |
GB9400413A GB9400413D0 (en) | 1994-01-11 | 1994-01-11 | Compounds |
PCT/GB1994/001374 WO1995000649A1 (en) | 1993-06-25 | 1994-06-24 | Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69423436D1 true DE69423436D1 (de) | 2000-04-20 |
DE69423436T2 DE69423436T2 (de) | 2000-09-07 |
Family
ID=26303121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69423436T Expired - Lifetime DE69423436T2 (de) | 1993-06-25 | 1994-06-24 | An lipoprotein gebundene phospholipase a2, inhibitoren davon und deren verwendung für diagnose und therapie |
Country Status (5)
Country | Link |
---|---|
US (13) | US5981252A (de) |
EP (2) | EP0974663A1 (de) |
JP (1) | JPH08500740A (de) |
DE (1) | DE69423436T2 (de) |
WO (1) | WO1995000649A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5981252A (en) | 1993-06-25 | 1999-11-09 | Smithkline Beecham | Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy |
US5977308A (en) * | 1993-10-06 | 1999-11-02 | Icos Corporation | Platelet-activating factor acetylhydrolase |
US6146625A (en) | 1993-10-06 | 2000-11-14 | Icos Corporation | Platelet-activating factor acetylhydrolase |
US5847088A (en) * | 1993-10-06 | 1998-12-08 | Icos Corporation | Antibodies specific for platelet-activating factor acetylhydrolase |
EP1634953A3 (de) * | 1993-10-06 | 2006-06-28 | ICOS Corporation | Acethylhydrolase des Plättchen aktivierenden Faktors |
US5656431A (en) * | 1993-10-06 | 1997-08-12 | Icos Corporation | Platelet-activating factor acetylhydrolase |
CA2233300A1 (en) * | 1995-09-29 | 1997-04-10 | Christopher Donald Southan | A paf-acetylhydrolase and use in therapy |
AU3572895A (en) * | 1995-09-29 | 1997-04-28 | Smithkline Beecham Plc | Compound having sequence homology with lipoprotein associated phospholipase a2 (lp-pla2)/paf acetyl hydrolase |
JP2000502079A (ja) * | 1995-12-08 | 2000-02-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | アテローム性動脈硬化症の治療のための単環β―ラクタム誘導体 |
WO1997035567A1 (en) * | 1996-03-26 | 1997-10-02 | Smithkline Beecham Corporation | Pla2 inhibitors of angiogenesis |
TR199802160T2 (xx) * | 1996-04-26 | 1999-04-21 | Smithkline Beecham Plc | Ateroskleroz tedavisi i�in azetidinon t�revleri. |
WO1998012561A1 (en) * | 1996-09-20 | 1998-03-26 | Atherogenics, Inc. | Diagnostics for and mediators of inflammatory disorders |
WO1999009147A1 (en) * | 1997-08-13 | 1999-02-25 | Icos Corporation | Truncated platelet-activating factor acetylhydrolase |
JP2002528084A (ja) * | 1998-10-28 | 2002-09-03 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 固定化金属アフィニティークロマトグラフィーを用いる低密度リポタンパク質関連ホスホリパーゼa2の精製方法 |
ES2267714T3 (es) | 2000-02-16 | 2007-03-16 | Smithkline Beecham Plc | Derivado de pirimidin-4-ona inhibidor de ldl-pla2. |
JPWO2002000621A1 (ja) * | 2000-06-29 | 2004-04-22 | 塩野義製薬株式会社 | X型sPLA2阻害作用を有する化合物 |
GB0024808D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
GB0027181D0 (en) * | 2000-11-04 | 2000-12-27 | S P A | New use |
TWI314457B (de) * | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
US7468266B2 (en) * | 2001-05-30 | 2008-12-23 | Ryogen, Llc | Isolated genomic polynucleotide fragments that encode human lipoprotein-associated phospholipase A2 |
WO2003101177A2 (en) * | 2002-06-04 | 2003-12-11 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
JP2006508642A (ja) * | 2002-06-27 | 2006-03-16 | ハークネス ファーマシューティカルズ,インコーポレイティド | 脂肪の蓄積を減少させる方法と、関連疾患を治療するための方法 |
AU2003248793A1 (en) * | 2002-06-27 | 2004-01-19 | Sequenom, Inc | Diagnosing predisposition to fat deposition and associated condition |
US20070077614A1 (en) * | 2003-04-01 | 2007-04-05 | Wolfert Robert L | Uses of lp-pla2 in combination to assess coronary risk |
EP2253702A1 (de) * | 2003-05-28 | 2010-11-24 | Glaxo Group Limited | LP-PLA2-Aktivitätstest mit hohem Durchsatz |
EP1718967B1 (de) * | 2004-02-03 | 2013-04-24 | Diadexus, Inc. | Verfahren zum nachweis von lp-pla2-aktivität |
US20050244892A1 (en) * | 2004-02-27 | 2005-11-03 | Lazar Mitchell A | Resistin as a marker and therapeutic target for cardiovascular disease |
US20150017671A1 (en) | 2004-04-16 | 2015-01-15 | Yaping Shou | Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity |
JP4812751B2 (ja) * | 2004-04-16 | 2011-11-09 | グラクソ グループ リミテッド | Lp−PLA2活性およびLp−PLA2活性阻害を検出する方法 |
US20070149001A1 (en) * | 2005-12-22 | 2007-06-28 | Uka Harshad K | Flexible circuit |
EP1989144A4 (de) | 2006-02-02 | 2014-01-29 | Innovative Bio Therapies | Extrakorporale zellbasierte therapeutische vorrichtung und freisetzungssystem |
EA200971050A1 (ru) | 2007-05-11 | 2010-06-30 | Томас Джефферсон Юниверсити | Способы лечения и предупреждения нейродегенеративных заболеваний и нарушений |
CA2687079A1 (en) * | 2007-05-11 | 2008-11-20 | The Trustees Of The University Of Pennsylvania | Methods of treatment of skin ulcers |
EP2291515A2 (de) | 2008-06-18 | 2011-03-09 | Innovative Biotherapies, Inc. | Verfahren zur fortpflanzung von nierenvorläuferzellen |
JP5855055B2 (ja) * | 2008-07-28 | 2016-02-09 | キヤノン株式会社 | 化合物、ナノ粒子−分散剤複合体、ナノ粒子分散液およびナノ粒子−マトリックス材料複合体、化合物の製造方法 |
WO2012080497A2 (en) | 2010-12-17 | 2012-06-21 | Glaxo Group Limited | Methods of treatment and prevention of eye diseases |
RU2513194C1 (ru) * | 2013-01-31 | 2014-04-20 | Федеральное государственное бюджетное учреждение "Научный центр неврологии" Российской академии медицинских наук (ФГБУ "НЦН" РАМН) | Способ выявления развития гиперплазии неоинтимы и рестеноза сонных артерий после ангиореконструктивных операций на них у больных с прогрессирующим церебральным атеросклерозом |
US20140283157A1 (en) | 2013-03-15 | 2014-09-18 | Diadexus, Inc. | Lipoprotein-associated phospholipase a2 antibody compositions and methods of use |
WO2017151939A1 (en) | 2016-03-02 | 2017-09-08 | The Brigham And Women's Hospital, Inc. | Use of pla2g5-deficient suppressive macrophages in suppression of inflammation |
CN106957824B (zh) * | 2016-12-27 | 2018-02-23 | 南京诺唯赞医疗科技有限公司 | 耐脂蛋白干扰的抗人Lp‑PLA2蛋白的单克隆抗体及其应用 |
EP3661602B1 (de) | 2017-08-03 | 2021-05-26 | Karl-Franzens-Universität Graz | Phospholipidanaloga |
CN112210012A (zh) * | 2020-10-12 | 2021-01-12 | 南京佰抗生物科技有限公司 | 高特异性和强亲和力的抗人Lp-PLA2蛋白的单克隆抗体及其应用 |
Family Cites Families (38)
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GR851819B (de) * | 1984-08-17 | 1985-11-26 | Wyeth John & Brother Ltd | |
WO1987002367A2 (en) * | 1985-10-18 | 1987-04-23 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
US5373095A (en) * | 1985-10-18 | 1994-12-13 | The Upjohn Company | Steroid compounds |
US5081147A (en) * | 1990-03-15 | 1992-01-14 | Allergan, Inc. | 4-(1-hydroxy-2-substituted amino)ethyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
US5019508A (en) * | 1987-08-27 | 1991-05-28 | Biotechnology Research Partners, Ltd. | Synovial phospholipases |
IL84252A (en) * | 1987-10-23 | 1994-02-27 | Yissum Res Dev Co | Phospholipase inhibiting compositions |
JPH03503843A (ja) * | 1988-04-15 | 1991-08-29 | バイオジェン インコーポレイテッド | ホスホリパーゼa2の精製方法およびホスホリパーゼa2様ポリペプチドの製造方法 |
JPH0265781A (ja) * | 1988-08-29 | 1990-03-06 | Shionogi & Co Ltd | ヒト膵蔵ホスホリパーゼa↓2の製造法 |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5108899A (en) * | 1989-10-31 | 1992-04-28 | Exoxemis, Inc. | Chemiluminescence assay of in vivo inflammation |
US5622832A (en) | 1990-02-28 | 1997-04-22 | Genetics Institute, Inc. | Arachidonic acid releasing phospholipase A2 enzyme and methods of use |
JPH03258749A (ja) * | 1990-03-07 | 1991-11-19 | Ono Pharmaceut Co Ltd | ベンゾフェノン誘導体、それらの製造方法、およびそれらを含有する薬剤 |
US5081261A (en) * | 1990-03-23 | 1992-01-14 | Allergan, Inc. | 4-(1-hydroxy-2-N-substituted sulfonamido) ethyl-5-hydroxy-2(5H)-furanones and 4-(N-substituted sulfonamido)-2-ethenyl-5-hydroxy-2(5H)-furanones as anti-inflammatory agents |
US5210017A (en) * | 1990-11-19 | 1993-05-11 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
IL101507A0 (en) * | 1991-04-17 | 1992-12-30 | Lilly Co Eli | Compounds,vectors and methods for expressing human,cytosolic phospholipase a2 |
JP3036883B2 (ja) | 1991-05-24 | 2000-04-24 | 株式会社シノテスト | 血小板活性化因子アセチルヒドロラーゼ活性の測定法 |
US5171864A (en) * | 1991-08-30 | 1992-12-15 | Allergan, Inc. | Di-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega alkane-dioates and N,N-bis-(5-hydroxy-2(5H)-2-oxo-4-furyl)methyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents |
US5169963A (en) * | 1991-08-30 | 1992-12-08 | Allergan, Inc. | Di-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega alkanedioates and N,N-bis-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents |
US5279957A (en) * | 1992-04-30 | 1994-01-18 | Washington University | cDNA encoding human phospholipase A2 polypeptide |
JP3258749B2 (ja) | 1993-03-10 | 2002-02-18 | 株式会社東芝 | 感潮運河の浄化方法および浄化装置 |
US5981252A (en) | 1993-06-25 | 1999-11-09 | Smithkline Beecham | Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy |
JPH0759597A (ja) | 1993-08-23 | 1995-03-07 | Shinotesuto:Kk | 血小板活性化因子アセチルヒドロラーゼ活性測定方法 |
US5977308A (en) | 1993-10-06 | 1999-11-02 | Icos Corporation | Platelet-activating factor acetylhydrolase |
US5656431A (en) | 1993-10-06 | 1997-08-12 | Icos Corporation | Platelet-activating factor acetylhydrolase |
US5847088A (en) | 1993-10-06 | 1998-12-08 | Icos Corporation | Antibodies specific for platelet-activating factor acetylhydrolase |
EP1634953A3 (de) * | 1993-10-06 | 2006-06-28 | ICOS Corporation | Acethylhydrolase des Plättchen aktivierenden Faktors |
US6146625A (en) | 1993-10-06 | 2000-11-14 | Icos Corporation | Platelet-activating factor acetylhydrolase |
GB9421816D0 (en) * | 1994-10-29 | 1994-12-14 | Smithkline Beecham Plc | Novel compounds |
AU3572895A (en) | 1995-09-29 | 1997-04-28 | Smithkline Beecham Plc | Compound having sequence homology with lipoprotein associated phospholipase a2 (lp-pla2)/paf acetyl hydrolase |
US5840839A (en) | 1996-02-09 | 1998-11-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Alternative open reading frame DNA of a normal gene and a novel human cancer antigen encoded therein |
JPH1017600A (ja) | 1996-06-28 | 1998-01-20 | Suntory Ltd | 血小板活性化因子アセチルヒドロラーゼおよびその遺伝子 |
WO1998044158A1 (en) | 1997-03-28 | 1998-10-08 | Epitope, Inc. | Simultaneous collection of dna and non-nucleic analytes from oral fluids |
WO1999009147A1 (en) | 1997-08-13 | 1999-02-25 | Icos Corporation | Truncated platelet-activating factor acetylhydrolase |
WO1999064627A2 (en) | 1998-06-06 | 1999-12-16 | Genostic Pharma Limited | Probes used for genetic profiling |
JP2002528084A (ja) | 1998-10-28 | 2002-09-03 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 固定化金属アフィニティークロマトグラフィーを用いる低密度リポタンパク質関連ホスホリパーゼa2の精製方法 |
JP4220603B2 (ja) | 1998-12-02 | 2009-02-04 | アルフレッサファーマ株式会社 | 血小板活性化因子アセチルヒドロラーゼ活性の測定方法 |
GB0027181D0 (en) | 2000-11-04 | 2000-12-27 | S P A | New use |
-
1994
- 1994-06-24 US US08/387,858 patent/US5981252A/en not_active Expired - Lifetime
- 1994-06-24 DE DE69423436T patent/DE69423436T2/de not_active Expired - Lifetime
- 1994-06-24 JP JP7502593A patent/JPH08500740A/ja active Pending
- 1994-06-24 EP EP99201834A patent/EP0974663A1/de not_active Withdrawn
- 1994-06-24 WO PCT/GB1994/001374 patent/WO1995000649A1/en active IP Right Grant
- 1994-06-24 EP EP94918935A patent/EP0658205B1/de not_active Expired - Lifetime
-
1995
- 1995-11-14 US US08/557,892 patent/US5968818A/en not_active Expired - Lifetime
-
1996
- 1996-10-08 US US08/717,079 patent/US6369045B1/en not_active Expired - Lifetime
-
1999
- 1999-04-20 US US09/294,384 patent/US6177257B1/en not_active Expired - Lifetime
-
2001
- 2001-08-03 US US09/922,067 patent/US7045329B2/en not_active Expired - Fee Related
-
2002
- 2002-06-14 US US10/173,233 patent/US7052862B2/en not_active Expired - Fee Related
-
2003
- 2003-04-02 US US10/406,156 patent/US8088886B2/en not_active Expired - Fee Related
-
2004
- 2004-10-26 US US10/973,467 patent/US7217535B2/en not_active Expired - Fee Related
-
2005
- 2005-04-18 US US11/108,519 patent/US7314742B2/en not_active Expired - Fee Related
- 2005-05-31 US US11/141,554 patent/US20060040371A1/en not_active Abandoned
-
2006
- 2006-11-22 US US11/603,741 patent/US7416853B2/en not_active Expired - Fee Related
-
2007
- 2007-10-31 US US11/930,629 patent/US20090136969A1/en not_active Abandoned
-
2011
- 2011-08-11 US US13/208,015 patent/US20120045774A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1995000649A1 (en) | 1995-01-05 |
US6177257B1 (en) | 2001-01-23 |
EP0658205B1 (de) | 2000-03-15 |
US20030148398A1 (en) | 2003-08-07 |
US7217535B2 (en) | 2007-05-15 |
US6369045B1 (en) | 2002-04-09 |
US5981252A (en) | 1999-11-09 |
US7052862B2 (en) | 2006-05-30 |
JPH08500740A (ja) | 1996-01-30 |
EP0974663A1 (de) | 2000-01-26 |
DE69423436T2 (de) | 2000-09-07 |
US5968818A (en) | 1999-10-19 |
US7045329B2 (en) | 2006-05-16 |
US20050260731A1 (en) | 2005-11-24 |
US20070077251A1 (en) | 2007-04-05 |
US20090136969A1 (en) | 2009-05-28 |
US20120045774A1 (en) | 2012-02-23 |
US8088886B2 (en) | 2012-01-03 |
US20050106611A1 (en) | 2005-05-19 |
US7314742B2 (en) | 2008-01-01 |
US20020177209A1 (en) | 2002-11-28 |
US20030186421A1 (en) | 2003-10-02 |
US7416853B2 (en) | 2008-08-26 |
EP0658205A1 (de) | 1995-06-21 |
US20060040371A1 (en) | 2006-02-23 |
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