DE69424560D1 - Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschäden - Google Patents
Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschädenInfo
- Publication number
- DE69424560D1 DE69424560D1 DE69424560T DE69424560T DE69424560D1 DE 69424560 D1 DE69424560 D1 DE 69424560D1 DE 69424560 T DE69424560 T DE 69424560T DE 69424560 T DE69424560 T DE 69424560T DE 69424560 D1 DE69424560 D1 DE 69424560D1
- Authority
- DE
- Germany
- Prior art keywords
- producing
- nitrogen oxide
- protect against
- medicinal product
- ischemic reperfusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14661093A | 1993-11-02 | 1993-11-02 | |
PCT/US1994/012510 WO1995012394A1 (en) | 1993-11-02 | 1994-10-31 | Use of nitric oxide releasing compounds as protective agents in ischemia reperfusion injury |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69424560D1 true DE69424560D1 (de) | 2000-06-21 |
DE69424560T2 DE69424560T2 (de) | 2001-01-18 |
Family
ID=22518169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69424560T Expired - Fee Related DE69424560T2 (de) | 1993-11-02 | 1994-10-31 | Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschäden |
Country Status (12)
Country | Link |
---|---|
US (1) | US5789447A (de) |
EP (1) | EP0726768B1 (de) |
JP (1) | JPH09508097A (de) |
AT (1) | ATE192922T1 (de) |
AU (1) | AU704173B2 (de) |
CA (1) | CA2175467A1 (de) |
DE (1) | DE69424560T2 (de) |
DK (1) | DK0726768T3 (de) |
ES (1) | ES2149338T3 (de) |
GR (1) | GR3034099T3 (de) |
PT (1) | PT726768E (de) |
WO (1) | WO1995012394A1 (de) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6255277B1 (en) | 1993-09-17 | 2001-07-03 | Brigham And Women's Hospital | Localized use of nitric oxide-adducts to prevent internal tissue damage |
US6190704B1 (en) * | 1994-09-23 | 2001-02-20 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Regulation of wound healing by nitric oxide |
GB9423868D0 (en) * | 1994-11-25 | 1995-01-11 | Wellcome Found | Compounds for use in medicine |
US5726209A (en) * | 1995-06-07 | 1998-03-10 | Alliance Pharmaceutical Corp. | Liquid fluorocarbon emulsion as a vascular nitric oxide reservoir |
ATE331505T1 (de) * | 1996-04-05 | 2006-07-15 | Gen Hospital Corp | Behandlung einer hämoglobinstörung |
US6232434B1 (en) | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
US6656452B1 (en) | 1997-10-21 | 2003-12-02 | The General Hospital Corporation | Use of inhaled NO as anti-inflammatory agent |
WO1999033823A1 (en) * | 1997-12-23 | 1999-07-08 | Nycomed Imaging As | Nitric oxide releasing chelating agents and their therapeutic use |
US6103275A (en) * | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
US20040043068A1 (en) * | 1998-09-29 | 2004-03-04 | Eugene Tedeschi | Uses for medical devices having a lubricious, nitric oxide-releasing coating |
US20040151785A1 (en) * | 1998-10-06 | 2004-08-05 | Diamedica Inc. | Method for treating insulin resistance through hepatic nitric oxide |
CA2254645A1 (en) * | 1998-11-23 | 2000-05-23 | Pulmonox Medical Corporation | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
US20070086954A1 (en) * | 1998-11-23 | 2007-04-19 | Miller Christopher C | Method and apparatus for treatment of respiratory infections by nitric oxide inhalation |
ES2147162B1 (es) * | 1999-01-27 | 2001-03-16 | Lacer Sa | "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias". |
FR2794647A1 (fr) * | 1999-06-11 | 2000-12-15 | Centre Nat Rech Scient | Compositions pharmaceutique comprenant du no ou au moins un compose capable de liberer ou d'induire la formation de no dans les cellules |
DE60040299D1 (de) * | 1999-06-14 | 2008-10-30 | Ford Henry Health System | Stickstoffmonoxid-donoren zum induzieren von neurogenese |
US7135498B1 (en) | 1999-06-14 | 2006-11-14 | Henry Ford Health System | Nitric oxide donors for inducing neurogenesis |
US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
AU2001241908A1 (en) * | 2000-03-08 | 2001-09-17 | Frederick A. Gage | Kidney perfusion solution containing nitric oxide donor |
US6270779B1 (en) | 2000-05-10 | 2001-08-07 | United States Of America | Nitric oxide-releasing metallic medical devices |
FR2812200B1 (fr) | 2000-07-27 | 2003-01-03 | Oxykines Therapeutics | Composition contenant une proteine complexant le fer et un precurseur du metabolisme du monoxyde d'azote et/ou un donneur chimique de monoxyde d'azote ; et utilisations |
MXPA03001280A (es) | 2000-08-11 | 2004-07-30 | David R Whitlock | Composiciones que incluyen bacterias oxidadoras de amoniaco para incrementar la produccion de oxido nitrico y precursores de oxido nitrico y metodos para emplear las misams. |
US6432077B1 (en) * | 2000-12-26 | 2002-08-13 | Sensormedics Corporation | Device and method for treatment of surface infections with nitric oxide |
US7122018B2 (en) * | 2000-12-26 | 2006-10-17 | Sensormedics Corporation | Device and method for treatment of wounds with nitric oxide |
EP1436018A1 (de) * | 2001-09-26 | 2004-07-14 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Stickoxid freisetzende beschichtete medizinprodukte und verfahren zu ihrer herstellung |
US6703046B2 (en) * | 2001-10-04 | 2004-03-09 | Medtronic Ave Inc. | Highly cross-linked, extremely hydrophobic nitric oxide-releasing polymers and methods for their manufacture and use |
GB0125222D0 (en) * | 2001-10-19 | 2001-12-12 | Barts & London Nhs Trust | Composition for the treatment of microbial infections |
KR20040086267A (ko) * | 2002-01-11 | 2004-10-08 | 데이비드 알. 휘트록 | 암모니아 산화 박테리아를 포함하는 조성물 및 그를사용하는 방법 |
US20040038947A1 (en) * | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
WO2004017939A1 (ja) * | 2002-08-20 | 2004-03-04 | Terumo Kabushiki Kaisha | 体内埋込医療器具 |
US6936639B2 (en) * | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
US7531133B2 (en) * | 2002-09-10 | 2009-05-12 | Pulmonox Technologies Corporation | Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma |
US20050009789A1 (en) * | 2003-05-13 | 2005-01-13 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Service | Cyclooxygenase inhibition with nitroxyl |
ATE372777T1 (de) * | 2003-07-09 | 2007-09-15 | Us Gov Health & Human Serv | Verwendung von nitritsalzen zur behandlung von kardiovaskulären erkrankungen |
AU2004275868A1 (en) * | 2003-09-26 | 2005-04-07 | David R. Whitlock | Methods of using ammonia oxidizing bacteria |
US20080085329A1 (en) * | 2003-10-22 | 2008-04-10 | Fred Hutchinson Cancer Research Center, Inc. | Methods, Compositions and Devices for Inducing Stasis in Cells, Tissues, Organs, and Organisms |
US20050136125A1 (en) * | 2003-10-22 | 2005-06-23 | Roth Mark B. | Methods, compositions and devices for inducing stasis in cells, tissues, organs, and organisms |
AU2005215970A1 (en) | 2004-02-09 | 2005-09-09 | Noxilizer, Inc. | Nitric oxide-releasing molecules |
JP2007534389A (ja) * | 2004-04-29 | 2007-11-29 | キューブ・メディカル・アクティーゼルスカブ | 血管形成に用いるバルーン |
AU2005244078A1 (en) | 2004-05-11 | 2005-11-24 | Pulmonox Technologies Corporation | Intermittent dosing of nitric oxide gas |
US8518457B2 (en) * | 2004-05-11 | 2013-08-27 | Pulmonox Technologies Corporation | Use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
US7362274B1 (en) * | 2004-07-09 | 2008-04-22 | Huan-Cheng Lien | Coupled feed-in butterfly shaped left/right hand circularly polarized microstrip antenna |
US20070154570A1 (en) * | 2004-09-29 | 2007-07-05 | Miller Christopher C | Use of nitric oxide in the treatment and disinfection of biofilms |
CA2605631A1 (en) * | 2005-04-20 | 2006-10-26 | Fred Hutchinson Cancer Research Center | Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms |
US8557300B2 (en) * | 2005-05-19 | 2013-10-15 | University Of Cincinnati | Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite |
AU2006249323B2 (en) | 2005-05-27 | 2012-08-30 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
EP1909779A1 (de) * | 2005-06-23 | 2008-04-16 | Johns Hopkins University | Thiol-empfindliche positiv-inotrope |
US20070116785A1 (en) * | 2005-11-18 | 2007-05-24 | Miller Christopher C | Nitric oxide as an anti-viral agent, vaccine and vaccine adjuvant |
CA2632683A1 (en) * | 2005-12-06 | 2007-06-14 | Amulet Pharmaceuticals, Inc. | Nitric oxide-releasing polymers |
AU2014201936B2 (en) * | 2006-10-06 | 2016-07-07 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Prevention of tissue ischemia, related methods and compositions |
EP2695896B1 (de) | 2006-10-06 | 2018-08-22 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Prävention von Gewebeischämie, damit in Zusammenhang stehende Verfahren und Zusammensetzungen |
US8079998B2 (en) * | 2006-10-20 | 2011-12-20 | Pulmonox Technologies Corporation | Methods and devices for the delivery of therapeutic gases including nitric oxide |
EP1939179A1 (de) | 2006-12-28 | 2008-07-02 | Lacer, S.A. | Stabile S-Nitrosothiole, Syntheseverfahren und Verwendung |
WO2008089282A2 (en) * | 2007-01-16 | 2008-07-24 | Silver James H | Sensors for detecting subtances indicative of stroke, ischemia, infection or inflammation |
US20080193566A1 (en) * | 2007-02-09 | 2008-08-14 | Miller Christopher C | Use of high dose concentrations of gaseous nitric oxide |
WO2008134740A1 (en) * | 2007-04-30 | 2008-11-06 | The Trustees Of The University Of Pennsylvania | System and method of resuscitation of a mammal |
WO2009086470A2 (en) * | 2007-12-27 | 2009-07-09 | Aires Pharmaceuticals, Inc. | Aerosolized nitrite and nitric oxide - donating compounds and uses thereof |
EP2467173B8 (de) | 2009-08-21 | 2019-06-19 | Novan, Inc. | Wundverbände, verfahren zu ihrer anwendung und verfahren zu ihrer herstellung |
BR112012003792B1 (pt) | 2009-08-21 | 2020-05-19 | Novan Inc | composição tópica, e, uso da composição tópica |
WO2011063339A1 (en) * | 2009-11-23 | 2011-05-26 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl donors for the treatment of pulmonary hypertension |
CN105130855B (zh) | 2009-12-07 | 2018-05-25 | 约翰斯霍普金斯大学 | 二酰基化的羟基胺衍生物及其用途 |
WO2011071951A2 (en) * | 2009-12-07 | 2011-06-16 | Johns Hopkins University | N-acyloxysulfonamide and n-hydroxy-n-acylsulfonamide derivatives |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
WO2012154975A2 (en) * | 2011-05-11 | 2012-11-15 | Stc.Unm | Nitric oxide/cgmp pathway inhibition of vla-4 related cell adhesion |
WO2013173923A1 (en) | 2012-05-25 | 2013-11-28 | Diamedica, Inc. | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
SI2854841T1 (sl) | 2012-06-04 | 2017-06-30 | Diamedica Inc. | Glikozilacijske izooblike humanega tkivnega kalikreina-1 |
US8883857B2 (en) | 2012-12-07 | 2014-11-11 | Baylor College Of Medicine | Small molecule xanthine oxidase inhibitors and methods of use |
EP4219679A3 (de) | 2014-04-15 | 2023-08-09 | Aobiome LLC | Ammoniak-oxidierender nitrosomonas eutropha stamm d23 |
US11225640B2 (en) | 2014-04-15 | 2022-01-18 | Aobiome Llc | Ammonia oxidizing bacteria for treatment of psoriasis |
US10662063B1 (en) * | 2016-06-06 | 2020-05-26 | University Of Puerto Rico | Photosensitized release of nitric oxide |
CN109937234B (zh) | 2016-10-07 | 2021-11-26 | 北卡罗来纳大学教堂山分校 | S-亚硝基硫醇介导的超支化聚酯 |
EP3565848A4 (de) | 2017-01-03 | 2020-09-02 | The University of North Carolina at Chapel Hill | Stickoxidfreisetzende alginate als biologisch abbaubare antibakterielle gerüste und zugehörige verfahren |
JP2020510023A (ja) | 2017-03-09 | 2020-04-02 | ダイアメディカ, インコーポレイテッド | 組織カリクレイン1の剤形 |
EP3600338A4 (de) | 2017-03-28 | 2020-10-28 | The University of North Carolina at Chapel Hill | Stickoxidfreisetzende polyaminoglycoside als biologisch abbaubare antibakterielle gerüste und dazu zugehörige verfahren |
CN111836648A (zh) | 2018-03-06 | 2020-10-27 | 北卡罗来纳大学查佩尔希尔分校 | 作为可生物降解抗菌支架的一氧化氮释放型环糊精以及其相关方法 |
AU2019414421B2 (en) | 2018-12-28 | 2023-08-31 | The University Of North Carolina At Chapel Hill | Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3153094A (en) * | 1959-06-10 | 1964-10-13 | Du Pont | Nitrosamine manufacture |
US5039705A (en) * | 1989-09-15 | 1991-08-13 | The United States Of America As Represented By The Department Of Health And Human Services | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof |
US5212204A (en) * | 1989-10-18 | 1993-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Antihypertensive compositions and use thereof |
US5155137A (en) * | 1990-09-20 | 1992-10-13 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Complexes of nitric oxide with polyamines |
US5714511A (en) * | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
-
1994
- 1994-10-31 WO PCT/US1994/012510 patent/WO1995012394A1/en active IP Right Grant
- 1994-10-31 ES ES95900491T patent/ES2149338T3/es not_active Expired - Lifetime
- 1994-10-31 JP JP7513345A patent/JPH09508097A/ja active Pending
- 1994-10-31 AU AU81300/94A patent/AU704173B2/en not_active Ceased
- 1994-10-31 DK DK95900491T patent/DK0726768T3/da active
- 1994-10-31 EP EP95900491A patent/EP0726768B1/de not_active Expired - Lifetime
- 1994-10-31 AT AT95900491T patent/ATE192922T1/de not_active IP Right Cessation
- 1994-10-31 PT PT95900491T patent/PT726768E/pt unknown
- 1994-10-31 DE DE69424560T patent/DE69424560T2/de not_active Expired - Fee Related
- 1994-10-31 CA CA002175467A patent/CA2175467A1/en not_active Abandoned
-
1995
- 1995-09-12 US US08/527,314 patent/US5789447A/en not_active Expired - Fee Related
-
2000
- 2000-08-02 GR GR20000401796T patent/GR3034099T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK0726768T3 (da) | 2000-10-02 |
WO1995012394A1 (en) | 1995-05-11 |
CA2175467A1 (en) | 1995-05-11 |
ES2149338T3 (es) | 2000-11-01 |
EP0726768B1 (de) | 2000-05-17 |
US5789447A (en) | 1998-08-04 |
AU8130094A (en) | 1995-05-23 |
PT726768E (pt) | 2000-11-30 |
EP0726768A1 (de) | 1996-08-21 |
DE69424560T2 (de) | 2001-01-18 |
ATE192922T1 (de) | 2000-06-15 |
AU704173B2 (en) | 1999-04-15 |
GR3034099T3 (en) | 2000-11-30 |
JPH09508097A (ja) | 1997-08-19 |
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