DE69428280D1 - Verfahren zur herstellung von azetidinonen - Google Patents

Verfahren zur herstellung von azetidinonen

Info

Publication number
DE69428280D1
DE69428280D1 DE69428280T DE69428280T DE69428280D1 DE 69428280 D1 DE69428280 D1 DE 69428280D1 DE 69428280 T DE69428280 T DE 69428280T DE 69428280 T DE69428280 T DE 69428280T DE 69428280 D1 DE69428280 D1 DE 69428280D1
Authority
DE
Germany
Prior art keywords
substituted
pct
beta
amino
azetidinones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69428280T
Other languages
English (en)
Other versions
DE69428280T2 (de
Inventor
Kannapan Thiruvengadam
Timothy Mcallister
Chou-Hong Tann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22217215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69428280(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of DE69428280D1 publication Critical patent/DE69428280D1/de
Publication of DE69428280T2 publication Critical patent/DE69428280T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
DE69428280T 1993-07-09 1994-07-01 Verfahren zur herstellung von azetidinonen Expired - Lifetime DE69428280T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8935793A 1993-07-09 1993-07-09
PCT/US1994/007291 WO1995001961A1 (en) 1993-07-09 1994-07-01 Process for the synthesis of azetidinones

Publications (2)

Publication Number Publication Date
DE69428280D1 true DE69428280D1 (de) 2001-10-18
DE69428280T2 DE69428280T2 (de) 2002-06-13

Family

ID=22217215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69428280T Expired - Lifetime DE69428280T2 (de) 1993-07-09 1994-07-01 Verfahren zur herstellung von azetidinonen

Country Status (21)

Country Link
US (1) US5728827A (de)
EP (1) EP0707567B1 (de)
JP (1) JP2840452B2 (de)
KR (1) KR0176001B1 (de)
CN (1) CN1071745C (de)
AT (1) ATE205475T1 (de)
AU (1) AU681419B2 (de)
CA (1) CA2166784C (de)
CZ (1) CZ7696A3 (de)
DE (1) DE69428280T2 (de)
DK (1) DK0707567T3 (de)
ES (1) ES2160125T3 (de)
FI (1) FI960095A (de)
HU (1) HUT73237A (de)
MX (1) MX9405152A (de)
NO (1) NO306294B1 (de)
NZ (1) NZ268798A (de)
PL (1) PL312502A1 (de)
PT (1) PT707567E (de)
SK (1) SK3796A3 (de)
WO (1) WO1995001961A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6207822B1 (en) 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones
CA2353981C (en) * 1998-12-07 2005-04-26 Schering Corporation Process for the synthesis of azetidinones
WO2000063703A1 (en) 1999-04-16 2000-10-26 Schering Corporation Use of azetidinone compounds
AU2002247019C1 (en) * 2001-01-26 2017-05-11 Organon Llc Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
SK287408B6 (sk) 2001-03-28 2010-09-07 Schering Corporation Spôsob prípravy medziproduktov na výrobu azetidinónov
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
PT1429756E (pt) * 2001-09-21 2007-01-31 Schering Corp Tratamento de xantoma com derivados de azetidinona como inibidores de absorção de esteróis
US20030204096A1 (en) * 2002-03-25 2003-10-30 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
US7135556B2 (en) * 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
US7208486B2 (en) * 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
ES2311806T3 (es) * 2003-03-07 2009-02-16 Schering Corporation Compuesto de azetidinona sustituidos, fornulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
CN100471835C (zh) * 2003-12-23 2009-03-25 默克公司 抗高胆固醇血症化合物
EP1699759B1 (de) 2003-12-23 2010-10-20 AstraZeneca AB Diphenylazetidinonderivate mit die cholesterinabsorption hemmender wirkung
WO2005069900A2 (en) * 2004-01-16 2005-08-04 Merck & Co., Inc. Npc1l1 (npc3) and methods of identifying ligands thereof
DE102004025071B4 (de) * 2004-05-21 2006-12-21 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Diphenylazetidinon-Derivaten
MXPA06013456A (es) 2004-05-21 2007-03-01 Sanofi Aventis Deutschland Metodo para producir derivados de 1,4-difenilazetidinona.
CN101119966B (zh) 2004-12-20 2014-08-13 默沙东公司 合成2-吖丁啶酮的方法
CA2610959A1 (en) * 2005-06-20 2007-01-04 Schering Corporation Piperidine derivatives useful as histamine h3 antagonists
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
EP1986489A2 (de) 2006-02-24 2008-11-05 Schering Corporation Npc1l1-orthologe
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
WO2008030382A1 (en) * 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
WO2008032338A2 (en) * 2006-09-11 2008-03-20 Manne Satyanarayana Reddy Improved process for the preparation of ezetimibe and its intermediates
CN102285906B (zh) 2007-01-24 2014-11-19 克尔克公司 依泽替米贝的制备方法和其的衍生物
US9388440B2 (en) 2009-04-01 2016-07-12 Mylan Laboratories Limited Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of Ezetimibe and further conversion to Ezetimibe
CN104803858B (zh) * 2014-01-23 2019-03-01 东莞东阳光科研发有限公司 一种制备四丁基氟化铵三水合物的方法
TW202142538A (zh) 2020-02-07 2021-11-16 美商迦舒布魯姆生物有限公司 雜環glp-1促效劑

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333268A1 (de) * 1988-03-18 1989-09-20 Merck & Co. Inc. Verfahren zur Synthese eines chiralen 3-beta-Wasserstoff-(3R) 4-aroyloxyazetidinons
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US4983597A (en) * 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
US5085473A (en) * 1990-10-09 1992-02-04 Yuhe Yang Air actuated car curtain device
EP0596015B1 (de) * 1991-07-23 1997-10-01 Schering Corporation Substituierte beta-lactam-verbindungen als hypocholesterolemische mittel und verfahren zu deren herstellung

Also Published As

Publication number Publication date
PL312502A1 (en) 1996-04-29
JP2840452B2 (ja) 1998-12-24
CA2166784C (en) 2001-12-11
KR960703853A (ko) 1996-08-31
US5728827A (en) 1998-03-17
NZ268798A (en) 1997-01-29
DK0707567T3 (da) 2001-11-26
DE69428280T2 (de) 2002-06-13
CA2166784A1 (en) 1995-01-19
WO1995001961A1 (en) 1995-01-19
SK3796A3 (en) 1997-02-05
MX9405152A (es) 1995-01-31
EP0707567B1 (de) 2001-09-12
FI960095A0 (fi) 1996-01-09
ES2160125T3 (es) 2001-11-01
NO306294B1 (no) 1999-10-18
FI960095A (fi) 1996-01-09
AU7214694A (en) 1995-02-06
ATE205475T1 (de) 2001-09-15
JPH08507085A (ja) 1996-07-30
CZ7696A3 (en) 1996-04-17
EP0707567A1 (de) 1996-04-24
KR0176001B1 (ko) 1999-03-20
CN1126989A (zh) 1996-07-17
PT707567E (pt) 2002-01-30
AU681419B2 (en) 1997-08-28
NO960083L (no) 1996-03-04
NO960083D0 (no) 1996-01-08
CN1071745C (zh) 2001-09-26
HUT73237A (en) 1996-07-29
HU9503748D0 (en) 1996-02-28

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings