DE69429159T2 - Verfahren für einen spezifischen Bindungstest mit magnetischen Teilchen - Google Patents
Verfahren für einen spezifischen Bindungstest mit magnetischen TeilchenInfo
- Publication number
- DE69429159T2 DE69429159T2 DE69429159T DE69429159T DE69429159T2 DE 69429159 T2 DE69429159 T2 DE 69429159T2 DE 69429159 T DE69429159 T DE 69429159T DE 69429159 T DE69429159 T DE 69429159T DE 69429159 T2 DE69429159 T2 DE 69429159T2
- Authority
- DE
- Germany
- Prior art keywords
- magnetic particle
- specific magnetic
- binding test
- particle binding
- test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/286—Magnetic plugs and dipsticks disposed at the inner circumference of a recipient, e.g. magnetic drain bolt
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0657—Pipetting powder
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1055—General features of the devices using the transfer device for another function for immobilising reagents, e.g. dried reagents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/806—Electrical property or magnetic property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI930440A FI930440A0 (fi) | 1993-02-01 | 1993-02-01 | Bestaemningsfoerfarande |
FI932866A FI932866A0 (fi) | 1993-06-21 | 1993-06-21 | Separeringsfoerfarande |
PCT/FI1994/000048 WO1994018565A1 (en) | 1993-02-01 | 1994-02-01 | Method and means for magnetic particle specific binding assay |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69429159D1 DE69429159D1 (de) | 2002-01-03 |
DE69429159T2 true DE69429159T2 (de) | 2002-08-14 |
Family
ID=26159425
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69434867T Expired - Lifetime DE69434867T2 (de) | 1993-02-01 | 1994-02-01 | Gerät zur Bestimmung eines Analyten in einer Probe |
DE69429159T Expired - Lifetime DE69429159T2 (de) | 1993-02-01 | 1994-02-01 | Verfahren für einen spezifischen Bindungstest mit magnetischen Teilchen |
DE1130397T Pending DE1130397T1 (de) | 1993-02-01 | 1994-02-01 | Ausrüstung zur Bestimmung eines Analyten in einer Probe |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69434867T Expired - Lifetime DE69434867T2 (de) | 1993-02-01 | 1994-02-01 | Gerät zur Bestimmung eines Analyten in einer Probe |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1130397T Pending DE1130397T1 (de) | 1993-02-01 | 1994-02-01 | Ausrüstung zur Bestimmung eines Analyten in einer Probe |
Country Status (7)
Country | Link |
---|---|
US (2) | US6040192A (de) |
EP (2) | EP1130397B1 (de) |
JP (1) | JP3142873B2 (de) |
DE (3) | DE69434867T2 (de) |
FI (1) | FI953669A (de) |
NO (1) | NO318762B1 (de) |
WO (1) | WO1994018565A1 (de) |
Families Citing this family (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994018565A1 (en) * | 1993-02-01 | 1994-08-18 | Labsystems Oy | Method and means for magnetic particle specific binding assay |
FI930440A0 (fi) | 1993-02-01 | 1993-02-01 | Labsystems Oy | Bestaemningsfoerfarande |
US5837144A (en) * | 1994-06-16 | 1998-11-17 | Boehringer Mannheim Gmbh | Method of magnetically separating liquid components |
FI944939A0 (fi) * | 1994-10-20 | 1994-10-20 | Labsystems Oy | Foerfarande foer separering av partiklar |
FI944937A0 (fi) | 1994-10-20 | 1994-10-20 | Labsystems Oy | Separeringsanordning |
FI944938A0 (fi) * | 1994-10-20 | 1994-10-20 | Labsystems Oy | Foerflyttningsanordning |
FI944940A0 (fi) * | 1994-10-20 | 1994-10-20 | Labsystems Oy | Tvaofasigt separeringsfoerfarande |
WO1997044671A1 (en) * | 1996-05-20 | 1997-11-27 | Precision System Science Co., Ltd. | Method and apparatus for controlling magnetic particles by pipetting machine |
EP0963554B1 (de) * | 1997-01-30 | 2002-10-23 | MERCK PATENT GmbH | Verfahren zur immunologischen bestimmung eines analyten |
DE19730497C2 (de) | 1997-07-16 | 2000-02-10 | Heermann Klaus Hinrich | Verfahren zum Waschen, zur Separierung und Konzentrierung von Biomolekülen unter Verwendung eines Magnetstifts |
US6248542B1 (en) | 1997-12-09 | 2001-06-19 | Massachusetts Institute Of Technology | Optoelectronic sensor |
EP1198566A2 (de) * | 1999-07-05 | 2002-04-24 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Methode mit einer hohen durchsatzrate zur selektion von interagierenden molekülen |
CA2379773C (en) * | 1999-07-19 | 2009-01-20 | Organon Teknika B.V. | Device and method for mixing magnetic particles with a fluid |
FI20000583A0 (fi) * | 2000-03-14 | 2000-03-14 | Labsystems Oy | Astia ja sauva |
US7410807B2 (en) * | 2000-07-24 | 2008-08-12 | D Aurora Vito J | Pregnancy and sex identification test based on saliva or other bodily fluids |
DE10057396C1 (de) * | 2000-11-18 | 2002-04-04 | Karlsruhe Forschzent | Verfahren zum Abtrennen eines dispergierten oder gelösten Stoffes und Magnetseparator |
US6649419B1 (en) | 2000-11-28 | 2003-11-18 | Large Scale Proteomics Corp. | Method and apparatus for protein manipulation |
US20050047976A1 (en) * | 2001-01-25 | 2005-03-03 | Klaus Gubernator | Method and apparatus for solid or solution phase reaction under ambient or inert conditions |
US7422860B2 (en) | 2001-02-07 | 2008-09-09 | Massachusetts Institute Of Technology | Optoelectronic detection system |
US8216797B2 (en) | 2001-02-07 | 2012-07-10 | Massachusetts Institute Of Technology | Pathogen detection biosensor |
US7214346B2 (en) | 2001-02-07 | 2007-05-08 | Massachusetts Institute Of Technology | Optoelectronic detection system |
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US20060188875A1 (en) * | 2001-09-18 | 2006-08-24 | Perlegen Sciences, Inc. | Human genomic polymorphisms |
AU2003226075B2 (en) * | 2002-04-12 | 2008-09-25 | Instrumentation Laboratory Company | Immunoassay probe |
FI120863B (fi) * | 2002-10-18 | 2010-04-15 | Biocontrol Systems Inc | Magneettinen siirtomenetelmä ja mikropartikkelien siirtolaite |
CN101398428B (zh) | 2002-11-07 | 2012-09-05 | 三菱化学美迪恩斯株式会社 | 用于收集磁性颗粒的磁性材料及其应用 |
KR100483684B1 (ko) * | 2003-01-29 | 2005-04-18 | (주)바이오넥스 | 핵산 또는 다양한 생물학적 물질을 분리 및 정제하기 위한키트와, 이러한 키트를 이용하여 생물학적 물질의 분리또는 정제 작업을 자동화하기 위한 시스템 |
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FI20040159A0 (fi) * | 2003-10-20 | 2004-02-02 | Bio Mobile Oy | Magneettinen siirtomenetelmä, mikropartikkelien siirtolaite, ja reaktioyksikkö |
FI20031635A0 (fi) | 2003-11-11 | 2003-11-11 | Thermo Electron Oy | Partikkelien erotusväline |
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GB2420850A (en) | 2004-12-03 | 2006-06-07 | Orion Diagnostica Oy | Particle based binding assay |
GB0503986D0 (en) * | 2005-02-26 | 2005-04-06 | Secr Defence | Reaction apparatus |
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AU2006350038B2 (en) * | 2005-11-30 | 2011-09-15 | Massachusetts Institute Of Technology | Pathogen detection biosensor |
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EP2229441B1 (de) | 2007-12-12 | 2014-10-01 | The Board of Trustees of The Leland Stanford Junior University | Verfahren und vorrichtung zur magnetischen trennung von zellen |
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CA2761276C (en) * | 2009-05-15 | 2017-06-27 | Gen-Probe Incorporated | Method and apparatus for effecting automated movement of a magnet in an instrument for performing a magnetic separation procedure |
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JP2011013042A (ja) * | 2009-06-30 | 2011-01-20 | Beckman Coulter Inc | 自動分析装置および測定方法 |
FR2951961B1 (fr) * | 2009-10-30 | 2011-11-04 | Snecma | Dispositif et procede de recuperation de particules magnetiques piegees sur un bouchon magnetique |
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- 1994-02-01 WO PCT/FI1994/000048 patent/WO1994018565A1/en active IP Right Grant
- 1994-02-01 DE DE69434867T patent/DE69434867T2/de not_active Expired - Lifetime
- 1994-02-01 DE DE69429159T patent/DE69429159T2/de not_active Expired - Lifetime
- 1994-02-01 JP JP06517693A patent/JP3142873B2/ja not_active Expired - Lifetime
- 1994-02-01 EP EP01107253A patent/EP1130397B1/de not_active Expired - Lifetime
- 1994-02-01 DE DE1130397T patent/DE1130397T1/de active Pending
- 1994-02-01 EP EP94905132A patent/EP0681700B1/de not_active Expired - Lifetime
-
1995
- 1995-07-31 NO NO19953014A patent/NO318762B1/no not_active IP Right Cessation
- 1995-08-01 FI FI953669A patent/FI953669A/fi not_active Application Discontinuation
-
1997
- 1997-08-26 US US08/920,094 patent/US6040192A/en not_active Expired - Lifetime
-
2000
- 2000-01-07 US US09/479,615 patent/US6447729B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP3142873B2 (ja) | 2001-03-07 |
EP0681700A1 (de) | 1995-11-15 |
WO1994018565A1 (en) | 1994-08-18 |
DE1130397T1 (de) | 2002-04-04 |
EP0681700B1 (de) | 2001-11-21 |
DE69434867T2 (de) | 2007-05-16 |
US6040192A (en) | 2000-03-21 |
FI953669A0 (fi) | 1995-08-01 |
NO953014D0 (no) | 1995-07-31 |
JPH08506661A (ja) | 1996-07-16 |
EP1130397A2 (de) | 2001-09-05 |
DE69434867D1 (de) | 2006-11-23 |
NO953014L (no) | 1995-10-02 |
EP1130397A3 (de) | 2004-01-14 |
FI953669A (fi) | 1995-08-01 |
EP1130397B1 (de) | 2006-10-11 |
DE69429159D1 (de) | 2002-01-03 |
NO318762B1 (no) | 2005-05-02 |
US6447729B1 (en) | 2002-09-10 |
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