DE69429422D1 - Ring-substituierte, unsymmetrische cyaninfarbstoffe - Google Patents

Ring-substituierte, unsymmetrische cyaninfarbstoffe

Info

Publication number
DE69429422D1
DE69429422D1 DE69429422T DE69429422T DE69429422D1 DE 69429422 D1 DE69429422 D1 DE 69429422D1 DE 69429422 T DE69429422 T DE 69429422T DE 69429422 T DE69429422 T DE 69429422T DE 69429422 D1 DE69429422 D1 DE 69429422D1
Authority
DE
Germany
Prior art keywords
alkyl
omega
different
fluorescent
viable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69429422T
Other languages
English (en)
Other versions
DE69429422T2 (de
Inventor
L Roth
J Millard
T Yue
Sam Wells
P Haugland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Molecular Probes Inc
Original Assignee
Molecular Probes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/090,890 external-priority patent/US5436134A/en
Priority claimed from US08/146,328 external-priority patent/US5545535A/en
Application filed by Molecular Probes Inc filed Critical Molecular Probes Inc
Publication of DE69429422D1 publication Critical patent/DE69429422D1/de
Application granted granted Critical
Publication of DE69429422T2 publication Critical patent/DE69429422T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
DE69429422T 1993-07-12 1994-04-13 Ring-substituierte, unsymmetrische cyaninfarbstoffe Expired - Lifetime DE69429422T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/090,890 US5436134A (en) 1993-04-13 1993-07-12 Cyclic-substituted unsymmetrical cyanine dyes
US08/146,328 US5545535A (en) 1993-04-13 1993-11-01 Fluorescent assay for bacterial gram reaction
US08/148,847 US5534416A (en) 1993-04-13 1993-11-08 Fluorescent viability assay using cyclic-substituted unsymmetrical cyanine dyes
PCT/US1994/004127 WO1994024213A1 (en) 1993-04-13 1994-04-13 Cyclic-substituted unsymmetrical cyanine dyes

Publications (2)

Publication Number Publication Date
DE69429422D1 true DE69429422D1 (de) 2002-01-24
DE69429422T2 DE69429422T2 (de) 2002-05-16

Family

ID=27376684

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429422T Expired - Lifetime DE69429422T2 (de) 1993-07-12 1994-04-13 Ring-substituierte, unsymmetrische cyaninfarbstoffe

Country Status (9)

Country Link
US (1) US5534416A (de)
EP (1) EP0675924B1 (de)
JP (4) JPH07196930A (de)
AT (1) ATE210703T1 (de)
AU (1) AU676317B2 (de)
CA (1) CA2133765C (de)
DE (1) DE69429422T2 (de)
ES (1) ES2166777T3 (de)
WO (1) WO1994024213A1 (de)

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AU6634594A (en) 1994-11-08
ES2166777T3 (es) 2002-05-01
CA2133765C (en) 1999-11-09
WO1994024213A1 (en) 1994-10-27
AU676317B2 (en) 1997-03-06
EP0675924B1 (de) 2001-12-12
ATE210703T1 (de) 2001-12-15
US5534416A (en) 1996-07-09
JP2005272479A (ja) 2005-10-06
JP2005344121A (ja) 2005-12-15
JPH07196930A (ja) 1995-08-01
JP4216267B2 (ja) 2009-01-28
DE69429422T2 (de) 2002-05-16
JP4684016B2 (ja) 2011-05-18
CA2133765A1 (en) 1994-10-27
JP2006111884A (ja) 2006-04-27
EP0675924A1 (de) 1995-10-11

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