DE69430406D1 - Abgabevorrichtungen mit gepulstem Effekt - Google Patents

Abgabevorrichtungen mit gepulstem Effekt

Info

Publication number
DE69430406D1
DE69430406D1 DE69430406T DE69430406T DE69430406D1 DE 69430406 D1 DE69430406 D1 DE 69430406D1 DE 69430406 T DE69430406 T DE 69430406T DE 69430406 T DE69430406 T DE 69430406T DE 69430406 D1 DE69430406 D1 DE 69430406D1
Authority
DE
Germany
Prior art keywords
orifice
dispensers
resilient material
beneficial agent
pulsatile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69430406T
Other languages
English (en)
Other versions
DE69430406T2 (de
Inventor
Stephen M Balaban
James B Pike
Jonathon P Smith
Clifton A Baile
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of DE69430406D1 publication Critical patent/DE69430406D1/de
Application granted granted Critical
Publication of DE69430406T2 publication Critical patent/DE69430406T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
DE69430406T 1993-05-05 1994-05-05 Abgabevorrichtungen mit gepulstem Effekt Expired - Lifetime DE69430406T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/058,151 US5308348A (en) 1992-02-18 1993-05-05 Delivery devices with pulsatile effect

Publications (2)

Publication Number Publication Date
DE69430406D1 true DE69430406D1 (de) 2002-05-23
DE69430406T2 DE69430406T2 (de) 2002-12-05

Family

ID=22015019

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430406T Expired - Lifetime DE69430406T2 (de) 1993-05-05 1994-05-05 Abgabevorrichtungen mit gepulstem Effekt

Country Status (5)

Country Link
US (1) US5308348A (de)
EP (1) EP0627231B1 (de)
AT (1) ATE216273T1 (de)
DE (1) DE69430406T2 (de)
ES (1) ES2171434T3 (de)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728088A (en) * 1988-12-13 1998-03-17 Alza Corporation Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals
US5672167A (en) * 1990-05-21 1997-09-30 Recordati Corporation Controlled release osmotic pump
US5658269A (en) * 1990-10-29 1997-08-19 The Procter & Gamble Company Extensible absorbent articles
US5456679A (en) * 1992-02-18 1995-10-10 Alza Corporation Delivery devices with pulsatile effect
US5498255A (en) * 1993-08-17 1996-03-12 Alza Corporation Osmotic device for protracted pulsatile delivery of agent
US5817144A (en) * 1994-10-25 1998-10-06 Latis, Inc. Method for contemporaneous application OF laser energy and localized pharmacologic therapy
US5836940A (en) * 1994-10-25 1998-11-17 Latis, Inc. Photoacoustic drug delivery
US5690952A (en) * 1995-06-07 1997-11-25 Judy A. Magruder et al. Implantable system for delivery of fluid-sensitive agents to animals
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5837284A (en) 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
RU2189221C2 (ru) * 1996-02-02 2002-09-20 Элзэ Копэрейшн Устройство для введения активного вещества (варианты), способ его изготовления и способ лечения пациента, страдающего раком предстательной железы
US6395292B2 (en) 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
US6261584B1 (en) 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
US6156331A (en) * 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
AU779186B2 (en) * 1996-02-02 2005-01-13 Intarcia Therapeutics, Inc. A fluid-imbibing implantable active agent delivery system
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
ES2158611T3 (es) * 1996-12-20 2001-09-01 Alza Corp Composicion en gel inyectable con efecto retard y procedimiento para la preparacion de dicha composicion.
DK0969820T3 (da) * 1997-03-24 2005-04-25 Alza Corp Implanterbar udleveringsanordning med en selvjusterende udgangsport
ZA981610B (en) * 1997-03-24 1999-08-26 Alza Corp Self adjustable exit port.
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
MY125849A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
US6450991B1 (en) 1997-12-05 2002-09-17 Interag Delivery devices and their use
DE69822208T2 (de) 1997-12-29 2005-04-28 Alza Corp., Mountain View Osmotisches verabreichungssystem mit stöpselrückhaltemechanismus
JP4494629B2 (ja) * 1997-12-30 2010-06-30 インターシア セラピューティクス，インコーポレイティド メンブレンプラグを備えた有益な作用剤の供給システム
ATE248002T1 (de) 1997-12-31 2003-09-15 Alza Corp System zur überwachung einer osmotischen wirkstoffabgabevorrichtung
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6099862A (en) * 1998-08-31 2000-08-08 Andrx Corporation Oral dosage form for the controlled release of a biguanide and sulfonylurea
US20010055613A1 (en) 1998-10-21 2001-12-27 Beth A. Burnside Oral pulsed dose drug delivery system
AU2997500A (en) * 1999-02-16 2000-09-04 Prismedical Corporation Single dose delivery device
US20030170181A1 (en) * 1999-04-06 2003-09-11 Midha Kamal K. Method for preventing abuse of methylphenidate
CA2368367A1 (en) 1999-04-06 2000-10-12 Pharmaquest Ltd. Pharmaceutical dosage form for pulsatile delivery of methylphenidate
DE60023361T2 (de) 1999-12-21 2006-04-27 Alza Corp., Mountain View Ventil für osmotische vorrichtungen
US20030211974A1 (en) * 2000-03-21 2003-11-13 Brodbeck Kevin J. Gel composition and methods
US6866866B1 (en) * 2000-11-03 2005-03-15 Andrx Labs, Llc Controlled release metformin compositions
US20060034922A1 (en) * 2000-11-03 2006-02-16 Andrx Labs, Llc Controlled release metformin compositions
US6790459B1 (en) 2000-11-03 2004-09-14 Andrx Labs, Llc Methods for treating diabetes via administration of controlled release metformin
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
SG106631A1 (en) * 2001-08-31 2004-10-29 Agency Science Tech & Res Liquid delivering device
CA2467239A1 (en) * 2001-11-14 2003-05-22 Alza Corporation Catheter injectable depot compositions and uses thereof
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
NZ533435A (en) * 2001-11-14 2007-10-26 Alza Corp Injectable depot compositions and uses thereof
WO2003045352A2 (en) * 2001-11-21 2003-06-05 Alza Corporation Osmotic delivery device having a two-way valve and dynamically self-adjusting flow channel
CN100493648C (zh) * 2002-04-08 2009-06-03 罗斯蒙德公司 可植入压力启动式微型阀
US6974587B2 (en) * 2002-05-08 2005-12-13 Aircom Manufacturing, Inc. Intraruminal device
US20040052848A1 (en) * 2002-05-23 2004-03-18 Xiu-Xiu Cheng Biguanide formulations
AR039729A1 (es) 2002-06-25 2005-03-09 Alza Corp Formulaciones de deposito de corta duracion
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ATE376854T1 (de) * 2002-06-26 2007-11-15 Alza Corp Minimal nachgiebiger volumen-effizienter kolben für osmotische medikamentenabgabesysteme
CA2494400A1 (en) * 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
IL166418A0 (en) * 2002-07-31 2006-01-15 Alza Corp Injectable depot compositions and uses thereof
US6913768B2 (en) * 2002-09-24 2005-07-05 Shire Laboratories, Inc. Sustained release delivery of amphetamine salts
MXPA05004927A (es) * 2002-11-06 2005-09-08 Alza Corp Formulaciones de deposito de liberacion controlada.
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
US7731947B2 (en) 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
AU2004227986A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems
JP2006521897A (ja) * 2003-03-31 2006-09-28 アルザ・コーポレーション 内部圧力を放散する手段を備える浸透ポンプ
KR20060002922A (ko) * 2003-03-31 2006-01-09 알자 코포레이션 비수성 단일 상 비히클 및 이러한 비히클을 이용한 제형
US6825255B2 (en) * 2003-05-01 2004-11-30 Solutia Incorporated Polyvinyl butyral sheet having antiblocking characteristics
US20070184084A1 (en) * 2003-05-30 2007-08-09 Guohua Chen Implantable elastomeric caprolactone depot compositions and uses thereof
CN1822816A (zh) * 2003-05-30 2006-08-23 阿尔萨公司 可植入的弹性体储库组合物、其用途以及制备方法
CA2545027A1 (en) * 2003-11-06 2005-05-26 Alza Corporation Modular imbibition rate reducer for use with implantable osmotic pump
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
JP2008523097A (ja) * 2004-12-09 2008-07-03 セルジーン・コーポレーション Ｄ−トレオメチルフェニデートを用いた治療
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US8022054B2 (en) 2005-11-28 2011-09-20 Marinus Pharmaceuticals Liquid ganaxolone formulations and methods for the making and use thereof
CN101453982B (zh) 2006-05-30 2011-05-04 精达制药公司 两件式内部通道渗透递送系统流动调节器
ES2422864T3 (es) 2006-08-09 2013-09-16 Intarcia Therapeutics, Inc Sistemas de liberación osmótica y unidades de pistón
EP2101735A2 (de) * 2006-11-28 2009-09-23 Marinus Pharmaceuticals, Inc. Nanoteilchenförmige formulierungen und verfahren zur herstellung und verwendung
RU2440097C2 (ru) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
EP2240155B1 (de) 2008-02-13 2012-06-06 Intarcia Therapeutics, Inc Vorrichtungen, formulierungen und verfahren zur freisetzung mehrerer wirkstoffe
IN2012DN00344A (de) 2009-07-10 2015-05-08 Becton Dickinson Co
ES2752923T3 (es) 2009-07-31 2020-04-06 Boehringer Ingelheim Animal Health Usa Inc Cápsulas de liberación prolongada
EP3323423B1 (de) 2009-09-28 2020-06-17 Intarcia Therapeutics, Inc Schnelle initiierung und/oder beendigung der verabreichung substantiell stabiler arzneimittel
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
EP3302354B1 (de) 2015-06-03 2023-10-04 i2o Therapeutics, Inc. Systeme zum einsetzen eines implantats
WO2017200943A1 (en) 2016-05-16 2017-11-23 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
BR112019002538A2 (pt) 2016-08-11 2019-05-21 Ovid Therapeutics Inc. uso de uma composição farmacêutica compreendendo um modulador alostérico, uso de uma composição farmacêutica compreendendo garboxadol ou um sal farmaceuticamente aceitável do mesmo, e composição farmacêutica para a administração parenteral
KR20190104039A (ko) 2017-01-03 2019-09-05 인타르시아 세라퓨틱스 인코포레이티드 Glp-1 수용체 효능제의 연속적인 투여 및 약물의 동시-투여를 포함하는 방법
US11083847B2 (en) 2018-01-26 2021-08-10 Becton, Dickinson And Company Flush syringe with flip cap
US11951288B2 (en) 2018-01-28 2024-04-09 Becton, Dickinson And Company Pulsatile or resonating flush syringe
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
US11266662B2 (en) 2018-12-07 2022-03-08 Marinus Pharmaceuticals, Inc. Ganaxolone for use in prophylaxis and treatment of postpartum depression
CA3145923A1 (en) 2019-08-05 2021-02-11 David Czekai Ganaxolone for use in treatment of status epilepticus
MX2022006014A (es) 2019-12-06 2022-06-22 Marinus Pharmaceuticals Inc Ganaxolona para uso en el tratamiento del complejo de esclerosis tuberosa.
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
WO2023181996A1 (ja) * 2022-03-25 2023-09-28 テルモ株式会社 投与装置

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3760806A (en) * 1971-01-13 1973-09-25 Alza Corp Helical osmotic dispenser with non-planar membrane
GB2092679B (en) * 1980-12-03 1984-12-12 Hepworth Gordon Liquid dispensing apparatus
JPS57163309A (en) * 1981-04-01 1982-10-07 Olympus Optical Co Ltd Capsule apparatus for medical use
US4416659A (en) * 1981-11-09 1983-11-22 Eli Lilly And Company Sustained release capsule for ruminants
US4777049A (en) * 1983-12-01 1988-10-11 Alza Corporation Constant release system with pulsed release
GR851195B (de) * 1984-06-02 1985-11-25 Castex Prod
GB8417202D0 (en) * 1984-07-05 1984-08-08 Norbrook Lab Ltd Drug intermittent release device
US4687423A (en) * 1985-06-07 1987-08-18 Ivac Corporation Electrochemically-driven pulsatile drug dispenser
US4842867A (en) * 1986-05-09 1989-06-27 Alza Corporation Pulsed drug delivery of doxylamine
US4723958A (en) * 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
US4867980A (en) * 1986-10-10 1989-09-19 Coopers Animal Health Australia Limited Heavy density depot
US4957494A (en) * 1987-06-25 1990-09-18 Alza Corporation Multi-layer delivery system
US4874388A (en) * 1987-06-25 1989-10-17 Alza Corporation Multi-layer delivery system
US5023088A (en) * 1987-06-25 1991-06-11 Alza Corporation Multi-unit delivery system
AT391416B (de) * 1988-06-23 1990-10-10 Annemarie Schloegl Ges M B H M Septum fuer implantierbare vorrichtungen zur abgabe von wirkstoffen
US4997420A (en) * 1989-12-28 1991-03-05 Lefevre Robert J Portable drug delivery device including pump with tapered barrel
US5122128A (en) * 1990-03-15 1992-06-16 Alza Corporation Orifice insert for a ruminal bolus
US5059175A (en) * 1990-10-09 1991-10-22 University Of Utah Research Foundation Implantable drug delivery system with piston actuation
US5167625A (en) * 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
US5196002A (en) * 1990-10-09 1993-03-23 University Of Utah Research Foundation Implantable drug delivery system with piston acutation
MX9201040A (es) * 1991-03-12 1992-09-01 Alza Corp Dispositivo de administracion en relacion al espacio y la estabilidad.
US5227167A (en) * 1991-06-11 1993-07-13 Alza Corporation Long-term delivery device including hydrophobic loading dose
US5137727A (en) * 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5209746A (en) * 1992-02-18 1993-05-11 Alza Corporation Osmotically driven delivery devices with pulsatile effect
US5221278A (en) * 1992-03-12 1993-06-22 Alza Corporation Osmotically driven delivery device with expandable orifice for pulsatile delivery effect

Also Published As

Publication number Publication date
EP0627231B1 (de) 2002-04-17
US5308348A (en) 1994-05-03
EP0627231A2 (de) 1994-12-07
ATE216273T1 (de) 2002-05-15
DE69430406T2 (de) 2002-12-05
ES2171434T3 (es) 2002-09-16
EP0627231A3 (de) 1995-08-30

Similar Documents

Publication Publication Date Title
DE69430406D1 (de) Abgabevorrichtungen mit gepulstem Effekt
ATE23672T1 (de) Aerosol-inhalationsvorrichtung.
TW270081B (de)
FR2656928B1 (fr) Dispositif ameliore d'immunotest du type plaquette a plonger, et trousse contenant ce dispositif.
DE69224215T2 (de) Schaumabgabevorrichtung vom triggertyp mit abdichtvorrichtung
ATE108648T1 (de) Implantierbare abgabevorrichtung.
ES2032102T3 (es) Capsula de presion para un recipiente rociador.
ES2079964T3 (es) Recipiente para la conservacion de flores frescas.
SE8601351D0 (sv) Styrd administration av fysiologiskt aktiva emnen
ES2083712T3 (es) Dispositivo de mando de distribucion de un producto, principalmente un producto autoespumante.
FR2314312A1 (fr) Activation physico-chimique de l'eau des douches et des chasses
DE59602988D1 (de) Tampon-Applikator
DE69124112T2 (de) Tropfenfänger
ATE222734T1 (de) Tauchbecher zur behandlung von zitzen bei tieren
SE9401681D0 (sv) För engångsanvändning avsett vätskeabsorberande alster, förfarande och användning för dess framställning
GR3022920T3 (en) Device for defence against insects.
SE9501631D0 (sv) Device for mixing a pharmaceutical composition with another agent
MX9303808A (es) Dispositivo para abrir y cerrar automaticamente un recipiente.
AR016200A1 (es) El uso de una composicion que comprende uno o mas compuestos que contienen azufre para la fabricacion de un medicamento para aumentar la permeabilidad deltejido corneo humano, y un kit que incluye dicha composicion
JPS577401A (en) Prevention of rottenness of remains
SU1454399A1 (ru) Устройство дл местной оксигенации
DE3377650D1 (en) Hydantoin therapeutic agents
JPS5535212A (en) Timer unit
JPS52144166A (en) Filth introducing device for filth reservoir
ATE177015T1 (de) Hilfsgerät für die wiederbelebung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition