DE69432147T2 - Topologisch getrennte kodierende festphasen-bibliotheken - Google Patents

Topologisch getrennte kodierende festphasen-bibliotheken

Info

Publication number
DE69432147T2
DE69432147T2 DE69432147T DE69432147T DE69432147T2 DE 69432147 T2 DE69432147 T2 DE 69432147T2 DE 69432147 T DE69432147 T DE 69432147T DE 69432147 T DE69432147 T DE 69432147T DE 69432147 T2 DE69432147 T2 DE 69432147T2
Authority
DE
Germany
Prior art keywords
test compound
synthetic test
libraries
molecules
structures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69432147T
Other languages
English (en)
Other versions
DE69432147D1 (de
Inventor
Michal Lebl
Kit S Lam
Sydney E Salmon
Victor Krchnak
Nikolai Sepetov
Peter Kocis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
SELECTIDE CORP TUCSON
Selectide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/249,830 external-priority patent/US5840485A/en
Application filed by SELECTIDE CORP TUCSON, Selectide Corp filed Critical SELECTIDE CORP TUCSON
Application granted granted Critical
Publication of DE69432147D1 publication Critical patent/DE69432147D1/de
Publication of DE69432147T2 publication Critical patent/DE69432147T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
DE69432147T 1993-05-27 1994-05-27 Topologisch getrennte kodierende festphasen-bibliotheken Expired - Lifetime DE69432147T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6832793A 1993-05-27 1993-05-27
US08/249,830 US5840485A (en) 1993-05-27 1994-05-26 Topologically segregated, encoded solid phase libraries
PCT/US1994/006078 WO1994028028A1 (en) 1993-05-27 1994-05-27 Topologically segregated, encoded solid phase libraries

Publications (2)

Publication Number Publication Date
DE69432147D1 DE69432147D1 (de) 2003-03-27
DE69432147T2 true DE69432147T2 (de) 2003-11-27

Family

ID=26748852

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69434998T Expired - Lifetime DE69434998T2 (de) 1993-05-27 1994-05-27 Topologisch getrennte, kodierende Festphasen-Bibliotheken
DE69432147T Expired - Lifetime DE69432147T2 (de) 1993-05-27 1994-05-27 Topologisch getrennte kodierende festphasen-bibliotheken

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69434998T Expired - Lifetime DE69434998T2 (de) 1993-05-27 1994-05-27 Topologisch getrennte, kodierende Festphasen-Bibliotheken

Country Status (12)

Country Link
US (1) US6090912A (de)
EP (1) EP0705279B1 (de)
JP (1) JP3394777B2 (de)
AT (2) ATE232882T1 (de)
AU (1) AU686186B2 (de)
CA (1) CA2163637C (de)
DE (2) DE69434998T2 (de)
DK (2) DK0705279T3 (de)
ES (2) ES2289194T3 (de)
NZ (1) NZ267843A (de)
PT (1) PT705279E (de)
WO (1) WO1994028028A1 (de)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184389B1 (en) 1994-01-11 2001-02-06 Isis Pharmaceuticals, Inc. Combinatorial libraries having aminodiol monomer subunits
US6828427B1 (en) 1994-01-11 2004-12-07 Isis Pharmaceuticals, Inc. Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
US6797522B1 (en) 1994-01-13 2004-09-28 The Trustees Of Columbia University In The City Of New York Synthetic receptors
US7067326B2 (en) 1994-01-13 2006-06-27 The Trustees Of Columbia University In The City Of New York Synthetic receptors, libraries and uses thereof
US5856083A (en) * 1994-05-06 1999-01-05 Pharmacopeia, Inc. Lawn assay for compounds that affect enzyme activity or bind to target molecules
US5824483A (en) * 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
JPH10512570A (ja) * 1995-01-20 1998-12-02 モレキュメティックス リミテッド コンホメーション的に制限された逆ターンライブラリおよびそれらに関連する方法
AU5375896A (en) 1995-03-27 1996-10-16 Isis Pharmaceuticals, Inc. Nitrogenous macrocyclic compounds
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US6251691B1 (en) * 1996-04-25 2001-06-26 Bioarray Solutions, Llc Light-controlled electrokinetic assembly of particles near surfaces
EP1726958A3 (de) * 1996-04-25 2007-07-11 BioArray Solutions Ltd. Lichtgesteuerte elektrokinetische Anordnung von Partikeln in der Nähe von Oberflächen
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
GB9610813D0 (en) * 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of benzufuran derivatives
US5922872A (en) * 1996-08-01 1999-07-13 Isis Pharmaceuticals, Inc. Meta-benzylic and alpha-amido compositions and methods for preparing same
US5817489A (en) 1996-08-01 1998-10-06 Isis Pharmaceuticals, Inc. Di-nitrogen heterocycle compositions
US5798360A (en) * 1996-08-01 1998-08-25 Isis Pharmaceuticals, Inc. N-(aminoalkyl)- and/or N-(amidoalkyl)- dinitrogen heterocyclic compositions
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles
US6077954A (en) 1996-08-01 2000-06-20 Isis Pharmaceuticals, Inc. Substituted heterocyclic compounds
US6057102A (en) * 1996-08-08 2000-05-02 The Aaron Diamond Aids Research Center HIV coreceptor mutants
US6127191A (en) * 1996-12-03 2000-10-03 3-Dimensional Pharmaceuticals, Inc. Aminobenzenedicarboxylic acid-based combinatorial libraries
US5969102A (en) 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
AU756945B2 (en) 1997-05-23 2003-01-30 Bioarray Solutions Ltd Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US6750344B1 (en) 1997-09-05 2004-06-15 Isis Pharmaceuticals, Inc. Amine compounds and combinatorial libraries comprising same
CA2324016A1 (en) * 1998-03-23 1999-09-30 President And Fellows Of Harvard College Synthesis of compounds and libraries of compounds
EP1144997A3 (de) * 1998-03-30 2002-08-28 The Regents of the University of California Methoden und verbindungen zur modulation nuklearer rezeptoraktivität
CA2342767C (en) * 1998-09-03 2009-11-03 Trellis Bioinformatics, Inc. Multihued labels
CA2343320A1 (en) 1998-09-18 2000-03-30 The Rockefeller University Lynx, a novel family of receptor ligands in the central nervous system, corresponding nucleic acids and proteins and uses therof
DE19924606A1 (de) * 1999-05-28 2000-11-30 Graffinity Pharm Design Gmbh Ligand-Anker-Konjugate
JP2003511362A (ja) * 1999-10-04 2003-03-25 ユニバーシティー オブ メディシン アンド デンティストリー オブ ニュー ジャージー 新規カルバメートおよび尿素類
EP1233970A2 (de) 1999-11-24 2002-08-28 Massachusetts Institute Of Technology Schutzgruppen nützlich bei der synthese von polysacchariden, natürliche produkte und kombinatorische bibliotheken
US6458538B1 (en) * 1999-12-14 2002-10-01 Ptc Therapeutics, Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
EP1311839B1 (de) 2000-06-21 2006-03-01 Bioarray Solutions Ltd Multianalytische molekularanalyse durch verwendung anwendungsspezifischer zufallspartikelarrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
EP1810978B1 (de) 2000-08-08 2013-02-13 St. Jude Children's Research Hospital Für Polypeptide aus Gruppe-B-Streptokokkus kodierende Nukleinsäuren und therapeutische Zusammensetzung sowie Impfstoffe daraus
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
DE10106339A1 (de) * 2001-02-09 2002-08-22 Hans-Joachim Mueller Verfahren zum Hochdurchsatz-Screening von Kandidaten-Verbindungen über die Hochdurchsatz-Direktsynthese von rekombinanten Polypeptiden
EP1572862B1 (de) 2001-02-20 2012-08-01 Intrexon Corporation Chimäre retinoid-x-rezeptoren und ihre verwendung in einem neuen induzierbaren genexpressionssystem auf ecdysonrezeptor-basis
DK1456346T3 (da) 2001-02-20 2012-05-29 Intrexon Corp Nyt inducerbart genekspressionssystem baseret på ecdysonreceptor/invertebrat-retinoid-x-receptor
DK1373470T3 (da) 2001-02-20 2013-07-29 Intrexon Corp Hidtil ukendte substitutionsmutantreceptorer og deres anvendelse i et cellekernereceptorbaseret inducerbart genekspressionssystem
JP4994563B2 (ja) 2001-02-20 2012-08-08 イントレキソン コーポレーション 新規置換突然変異体受容体および核受容体−ベースの誘導性遺伝子発現システムにおけるその使用
US20060228730A1 (en) * 2001-04-11 2006-10-12 Rando Robert F Methods for identifying small molecules that bind specific RNA structural motifs
WO2002083837A1 (en) * 2001-04-11 2002-10-24 Ptc Therapeutics, Inc. Methods for identifying small molecules that bind specific rna structural motifs
CA2381627C (en) * 2001-04-13 2010-06-22 Michael J. Mitrovich Solid lubricant and composition
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
WO2003019183A1 (en) * 2001-08-23 2003-03-06 Deltagen Research Laboratories, L.L.C. Process for the informative and iterative design of a gene-family screening library
US20030211040A1 (en) 2001-08-31 2003-11-13 Paul Greengard Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain
WO2003027266A2 (en) 2001-09-26 2003-04-03 Rheogene Holdings, Inc. Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
WO2003027289A1 (en) 2001-09-26 2003-04-03 Rheo Gene Holdings, Inc. Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
US20040002073A1 (en) 2001-10-15 2004-01-01 Li Alice Xiang Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
US7202030B2 (en) * 2001-11-01 2007-04-10 Rensselaer Polytechnic Institute Solid-phase array-based biocatalytic transformations
JP4508645B2 (ja) 2002-01-04 2010-07-21 ザ ロックフェラー ユニバーシティー アミロイド−βペプチド関連疾患の予防および治療用の組成物および方法
US7291456B2 (en) 2002-01-24 2007-11-06 The Regents Of The University Of California Method for determining differences in molecular interactions and for screening a combinatorial library
US20040171062A1 (en) * 2002-02-28 2004-09-02 Plexxikon, Inc. Methods for the design of molecular scaffolds and ligands
NZ535144A (en) * 2002-03-15 2006-03-31 Nuevolution As An improved method for synthesising templated molecules
EP1495318A4 (de) * 2002-04-15 2008-05-21 American Nat Red Cross Verfahren zum nachweis von liganden und zielen in einem gemisch
US20070015230A1 (en) * 2002-04-15 2007-01-18 Hammond David J Identification and characterization of analytes from whole blood
WO2004001010A2 (en) * 2002-06-21 2003-12-31 Ptc Therapeutics, Inc. METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
US7927791B2 (en) * 2002-07-24 2011-04-19 Ptc Therapeutics, Inc. Methods for identifying small molecules that modulate premature translation termination and nonsense mediated mRNA decay
EP1539980B1 (de) * 2002-08-01 2016-02-17 Nuevolution A/S MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN
CA2503905A1 (en) * 2002-09-16 2004-03-25 Plexxikon, Inc. Crystal structure of pim-1 kinase
US8791053B2 (en) * 2002-09-27 2014-07-29 Mpm-Holding Aps Spatially encoded polymer matrix
DK3299463T3 (da) 2002-10-30 2020-12-07 Nuevolution As Enzymatisk kodning
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
ES2686775T3 (es) 2003-01-31 2018-10-19 Mount Sinai School Of Medicine Of New York University Terapia de combinación para tratar trastornos de deficiencia de proteínas
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US20060269920A1 (en) * 2003-02-21 2006-11-30 Nuevolution A/S Method for obtaining structural information about an encoded molecule
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
JP2007524374A (ja) * 2003-02-28 2007-08-30 プレキシコン，インコーポレーテッド Ｐｙｋ２結晶構造および使用
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
CA2532403A1 (en) 2003-07-17 2005-02-03 James Arnold Ppar active compounds
US7348338B2 (en) * 2003-07-17 2008-03-25 Plexxikon, Inc. PPAR active compounds
US20050164300A1 (en) * 2003-09-15 2005-07-28 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
ATE447626T1 (de) * 2003-09-18 2009-11-15 Nuevolution As Methode zur gewinnung struktureller informationen kodierter moleküle und zur selektion von verbindungen
WO2005031305A2 (en) 2003-09-22 2005-04-07 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
US7563569B2 (en) 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
JP2007509629A (ja) 2003-10-29 2007-04-19 バイオアレイ ソリューションズ リミテッド 二本鎖ｄｎａの切断による複合核酸分析
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
SI1696920T1 (sl) 2003-12-19 2015-02-27 Plexxikon Inc. Spojine in postopki za razvoj modulatorjev ret
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP1742627A4 (de) 2004-05-06 2009-08-26 Plexxikon Inc Pde4b-hemmer und ihre verwendung
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
AU2005279795A1 (en) * 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl PDE4B inhibitors
WO2006060456A2 (en) * 2004-11-30 2006-06-08 Plexxikon, Inc. Indole derivatives for use as ppar ppar active compounds
US20060160135A1 (en) * 2004-12-08 2006-07-20 Weiru Wang SF-1 and LRH-1 modulator development
KR20080027775A (ko) * 2005-05-17 2008-03-28 플렉시콘, 인코퍼레이티드 피롤(２,３-ｂ)피리딘 유도체 단백질 키나제 억제제
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
US7863288B2 (en) * 2005-06-22 2011-01-04 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
CN101437539B (zh) 2005-07-05 2013-10-02 康奈尔研究基金会（有限公司） 通过干扰cd99l2阻断白细胞迁出和炎症
RU2419618C2 (ru) * 2005-09-07 2011-05-27 Плекссикон, Инк. Соединения, активные в отношении ppar (рецепторов активаторов пролиферации пероксисом)
CA2623705A1 (en) * 2005-09-27 2007-04-05 Bernd Helmut Adam Rehm Polymer particles and uses thereof
ATE490318T1 (de) * 2005-12-01 2010-12-15 Nuevolution As Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken
EP2074230B1 (de) 2006-10-11 2012-11-28 Janssen Pharmaceutica NV Zusammensetzungen und verfahren zur behandlung und diagnose von reizkolon
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
WO2008080015A2 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
PE20090159A1 (es) * 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
AU2008276063B2 (en) 2007-07-17 2013-11-28 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
BRPI1008429A2 (pt) 2009-02-13 2020-08-25 X-Chem, Inc. métodos de criação e de triagem de bibliotecas de dna codificado.
MX2011008303A (es) 2009-04-03 2011-11-29 Plexxikon Inc Composiciones del acido propano-1-sulfonico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil}-amida y el uso de las mismas.
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
EP2496086B1 (de) 2009-11-06 2017-05-31 Plexxikon Inc. Verbindungen und verfahren zur kinase-modulation und anzeigen dafür
CA2832672A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
CA2826123C (en) 2011-02-07 2016-08-09 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
EP3828271A1 (de) 2011-09-07 2021-06-02 X-Chem, Inc. Verfahren zur markierung dna-codierter bibliotheken
EP2776579B1 (de) 2011-11-07 2019-05-01 The Broad Institute, Inc. Propeptidluciferase-fusionsproteine und verfahren zu ihrer anwendung
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
ES2675167T3 (es) 2012-07-13 2018-07-09 X-Chem, Inc. Bibliotecas codificadas por ADN que tienen enlaces oligonucleotídicos codificantes no legibles por polimerasas
US9127024B2 (en) 2013-03-15 2015-09-08 Intrexon Corporation Boron-containing diacylhydrazines
MX2017003403A (es) 2014-09-17 2017-06-19 Intrexon Corp Compuestos de diacilhidrazina que contienen boro.
ES2958531T3 (es) 2015-10-14 2024-02-09 X Therma Inc Composiciones y métodos para reducir la formación de cristales de hielo
EP3387127A1 (de) 2015-12-07 2018-10-17 Erasmus University Medical Center Rotterdam Enzymatische ersatztherapie und antisense-therapie für pompe-krankheit
EP3243857A1 (de) * 2016-05-13 2017-11-15 Centre National de la Recherche Scientifique - CNRS - Gleichmässige sequenzdefinierte polyurethane und verwendungen davon als molekulare etiketten
NL2017294B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Natural cryptic exon removal by pairs of antisense oligonucleotides.
WO2018195019A1 (en) 2017-04-18 2018-10-25 The Broad Institute Inc. Compositions for detecting secretion and methods of use

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5182366A (en) * 1990-05-15 1993-01-26 Huebner Verena D Controlled synthesis of peptide mixtures using mixed resins
IE66205B1 (en) * 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5475085A (en) * 1991-02-07 1995-12-12 Molecumetics, Ltd. Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
WO1993002992A1 (en) * 1991-08-07 1993-02-18 H & N Instruments, Inc. Synthesis of chain chemical compounds
US5449754A (en) * 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
DE69217497T2 (de) * 1991-09-18 1997-06-12 Affymax Tech Nv Verfahren zur synthese der verschiedenen sammlungen von oligomeren
US5395750A (en) * 1992-02-28 1995-03-07 Hoffmann-La Roche Inc. Methods for producing proteins which bind to predetermined antigens
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
IL107166A (en) * 1992-10-01 2000-10-31 Univ Columbia Complex combinatorial chemical libraries encoded with tags
US5228514A (en) * 1992-11-19 1993-07-20 Ruska Laboratories, Inc. Gas trap apparatus
US5840485A (en) * 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
US5480971A (en) * 1993-06-17 1996-01-02 Houghten Pharmaceuticals, Inc. Peralkylated oligopeptide mixtures
IL106106A0 (en) * 1993-06-22 1993-10-20 Interpharm Lab Ltd Library of polymeric molecules and its preparation
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties

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DE69434998T2 (de) 2008-03-13
EP0705279B1 (de) 2003-02-19
AU7048694A (en) 1994-12-20
EP0705279A4 (de) 1999-03-24
PT705279E (pt) 2003-07-31
CA2163637C (en) 2008-05-06
AU686186B2 (en) 1998-02-05
ATE366741T1 (de) 2007-08-15
DE69434998D1 (de) 2007-08-23
ATE232882T1 (de) 2003-03-15
WO1994028028A1 (en) 1994-12-08
ES2289194T3 (es) 2008-02-01
CA2163637A1 (en) 1994-12-08
DK1310510T3 (da) 2007-09-24
DE69432147D1 (de) 2003-03-27
ES2204921T3 (es) 2004-05-01
JPH09501490A (ja) 1997-02-10
US6090912A (en) 2000-07-18
NZ267843A (en) 1997-10-24
DK0705279T3 (da) 2003-06-10
JP3394777B2 (ja) 2003-04-07
EP0705279A1 (de) 1996-04-10

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