DE69432147T2 - Topologisch getrennte kodierende festphasen-bibliotheken - Google Patents

Topologisch getrennte kodierende festphasen-bibliotheken

Info

Publication number
DE69432147T2
DE69432147T2 DE69432147T DE69432147T DE69432147T2 DE 69432147 T2 DE69432147 T2 DE 69432147T2 DE 69432147 T DE69432147 T DE 69432147T DE 69432147 T DE69432147 T DE 69432147T DE 69432147 T2 DE69432147 T2 DE 69432147T2
Authority
DE
Germany
Prior art keywords
test compound
synthetic test
libraries
molecules
structures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69432147T
Other languages
English (en)
Other versions
DE69432147D1 (de
Inventor
Michal Lebl
Kit S Lam
Sydney E Salmon
Victor Krchnak
Nikolai Sepetov
Peter Kocis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
SELECTIDE CORP TUCSON
Selectide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/249,830 external-priority patent/US5840485A/en
Application filed by SELECTIDE CORP TUCSON, Selectide Corp filed Critical SELECTIDE CORP TUCSON
Publication of DE69432147D1 publication Critical patent/DE69432147D1/de
Application granted granted Critical
Publication of DE69432147T2 publication Critical patent/DE69432147T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
DE69432147T 1993-05-27 1994-05-27 Topologisch getrennte kodierende festphasen-bibliotheken Expired - Lifetime DE69432147T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6832793A 1993-05-27 1993-05-27
US08/249,830 US5840485A (en) 1993-05-27 1994-05-26 Topologically segregated, encoded solid phase libraries
PCT/US1994/006078 WO1994028028A1 (en) 1993-05-27 1994-05-27 Topologically segregated, encoded solid phase libraries

Publications (2)

Publication Number Publication Date
DE69432147D1 DE69432147D1 (de) 2003-03-27
DE69432147T2 true DE69432147T2 (de) 2003-11-27

Family

ID=26748852

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69434998T Expired - Lifetime DE69434998T2 (de) 1993-05-27 1994-05-27 Topologisch getrennte, kodierende Festphasen-Bibliotheken
DE69432147T Expired - Lifetime DE69432147T2 (de) 1993-05-27 1994-05-27 Topologisch getrennte kodierende festphasen-bibliotheken

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69434998T Expired - Lifetime DE69434998T2 (de) 1993-05-27 1994-05-27 Topologisch getrennte, kodierende Festphasen-Bibliotheken

Country Status (12)

Country Link
US (1) US6090912A (de)
EP (1) EP0705279B1 (de)
JP (1) JP3394777B2 (de)
AT (2) ATE366741T1 (de)
AU (1) AU686186B2 (de)
CA (1) CA2163637C (de)
DE (2) DE69434998T2 (de)
DK (2) DK1310510T3 (de)
ES (2) ES2204921T3 (de)
NZ (1) NZ267843A (de)
PT (1) PT705279E (de)
WO (1) WO1994028028A1 (de)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184389B1 (en) 1994-01-11 2001-02-06 Isis Pharmaceuticals, Inc. Combinatorial libraries having aminodiol monomer subunits
US6828427B1 (en) 1994-01-11 2004-12-07 Isis Pharmaceuticals, Inc. Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
WO1995019567A1 (en) * 1994-01-13 1995-07-20 The Trustees Of Columbia University In The City Of New York Synthetic receptors, libraries and uses thereof
US6797522B1 (en) 1994-01-13 2004-09-28 The Trustees Of Columbia University In The City Of New York Synthetic receptors
US5856083A (en) * 1994-05-06 1999-01-05 Pharmacopeia, Inc. Lawn assay for compounds that affect enzyme activity or bind to target molecules
US5824483A (en) * 1994-05-18 1998-10-20 Pence Inc. Conformationally-restricted combinatiorial library composition and method
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
WO1996022304A1 (en) * 1995-01-20 1996-07-25 Molecumetics, Ltd. Conformationally constrained reverse-turn library and methods relating thereto
US6107482A (en) 1995-03-27 2000-08-22 Isis Pharmaceuticals, Inc. Nitrogenous macrocyclic compounds
US7144119B2 (en) * 1996-04-25 2006-12-05 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US6387707B1 (en) * 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
ES2288760T3 (es) * 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6958245B2 (en) 1996-04-25 2005-10-25 Bioarray Solutions Ltd. Array cytometry
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
EP1726958A3 (de) * 1996-04-25 2007-07-11 BioArray Solutions Ltd. Lichtgesteuerte elektrokinetische Anordnung von Partikeln in der Nähe von Oberflächen
GB9610813D0 (en) * 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of benzufuran derivatives
US5798360A (en) * 1996-08-01 1998-08-25 Isis Pharmaceuticals, Inc. N-(aminoalkyl)- and/or N-(amidoalkyl)- dinitrogen heterocyclic compositions
US5922872A (en) * 1996-08-01 1999-07-13 Isis Pharmaceuticals, Inc. Meta-benzylic and alpha-amido compositions and methods for preparing same
US6077954A (en) 1996-08-01 2000-06-20 Isis Pharmaceuticals, Inc. Substituted heterocyclic compounds
US5817489A (en) 1996-08-01 1998-10-06 Isis Pharmaceuticals, Inc. Di-nitrogen heterocycle compositions
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles
US6057102A (en) * 1996-08-08 2000-05-02 The Aaron Diamond Aids Research Center HIV coreceptor mutants
WO1998024760A1 (en) * 1996-12-03 1998-06-11 Graybill Todd L Aminobenzenedicarboxylic acid-based combinatorial libraries
US5969102A (en) 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
EP1003904B1 (de) * 1997-05-23 2007-07-11 BioArray Solutions Ltd. Farbkodierung und in situ abfrage von matrix-gekoppelten chemischen verbindungen
US6750344B1 (en) 1997-09-05 2004-06-15 Isis Pharmaceuticals, Inc. Amine compounds and combinatorial libraries comprising same
EP1066295A2 (de) * 1998-03-23 2001-01-10 President And Fellows Of Harvard College Synthese von verbindungen und substanzbibliotheken
WO1999050658A2 (en) * 1998-03-30 1999-10-07 The Regents Of The University Of California Methods and compounds for modulating nuclear receptor activity
WO2000014545A1 (en) * 1998-09-03 2000-03-16 Trellis Bioinformatics, Inc. Multihued labels
CA2343320A1 (en) 1998-09-18 2000-03-30 The Rockefeller University Lynx, a novel family of receptor ligands in the central nervous system, corresponding nucleic acids and proteins and uses therof
DE19924606A1 (de) * 1999-05-28 2000-11-30 Graffinity Pharm Design Gmbh Ligand-Anker-Konjugate
AU7856600A (en) * 1999-10-04 2001-05-10 University Of Medicine And Dentistry Of New Jersey Novel carbamates and ureas
EP1233970A2 (de) * 1999-11-24 2002-08-28 Massachusetts Institute Of Technology Schutzgruppen nützlich bei der synthese von polysacchariden, natürliche produkte und kombinatorische bibliotheken
US6458538B1 (en) * 1999-12-14 2002-10-01 Ptc Therapeutics, Inc. Methods of assaying for compounds that inhibit premature translation termination and nonsense-mediated RNA decay
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
ES2259666T3 (es) 2000-06-21 2006-10-16 Bioarray Solutions Ltd Analisis molecular de multiples analitos usando series de particulas aleatorias con especificidad de aplicacion.
EP1810978B1 (de) 2000-08-08 2013-02-13 St. Jude Children's Research Hospital Für Polypeptide aus Gruppe-B-Streptokokkus kodierende Nukleinsäuren und therapeutische Zusammensetzung sowie Impfstoffe daraus
US7057704B2 (en) * 2000-09-17 2006-06-06 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
DE10106339A1 (de) * 2001-02-09 2002-08-22 Hans-Joachim Mueller Verfahren zum Hochdurchsatz-Screening von Kandidaten-Verbindungen über die Hochdurchsatz-Direktsynthese von rekombinanten Polypeptiden
CA2441444C (en) 2001-02-20 2013-09-03 Rheogene Holdings, Inc. Novel ecdysone receptor/invertebrate retinoid x receptor-based inducible gene expression system
CA2445796C (en) 2001-02-20 2014-09-16 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
JP4955905B2 (ja) 2001-02-20 2012-06-20 イントレキソン コーポレーション キメラレチノイドx受容体および新規エクジソン受容体−ベースの誘導性遺伝子発現システムにおけるそれらの使用
CA2438133C (en) 2001-02-20 2015-01-27 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US20060228730A1 (en) * 2001-04-11 2006-10-12 Rando Robert F Methods for identifying small molecules that bind specific RNA structural motifs
WO2002083837A1 (en) * 2001-04-11 2002-10-24 Ptc Therapeutics, Inc. Methods for identifying small molecules that bind specific rna structural motifs
US6649573B2 (en) * 2001-04-13 2003-11-18 Michael J. Mitrovich Solid lubricant and composition
US7727713B2 (en) 2001-06-20 2010-06-01 Nuevolution A/S Templated molecules and methods for using such molecules
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
WO2003019183A1 (en) * 2001-08-23 2003-03-06 Deltagen Research Laboratories, L.L.C. Process for the informative and iterative design of a gene-family screening library
CA2459161A1 (en) 2001-08-31 2003-03-13 The Rockefeller University Phosphodiesterase activity and regulation of phosphodiesterase 1b-mediated signaling in brain
CA2820170C (en) 2001-09-26 2016-07-05 Intrexon Corporation Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
JP2005532781A (ja) 2001-09-26 2005-11-04 レオジーン・ホールディングス,インコーポレーテッド ヨコバイエクジソン受容体核酸、ポリペプチド、およびそれらの使用
EP2722395B1 (de) 2001-10-15 2018-12-19 Bioarray Solutions Ltd Gemultiplexte Analyse polymorphischer Stellen durch gleichzeitige Abfrage und enzymvermittelte Detektion
AU2002353996A1 (en) * 2001-11-01 2003-05-12 Rensselaer Polytechnic Institute Solid-phase array-based biocatalytic transformations
JP4508645B2 (ja) 2002-01-04 2010-07-21 ザ ロックフェラー ユニバーシティー アミロイド−βペプチド関連疾患の予防および治療用の組成物および方法
US7291456B2 (en) 2002-01-24 2007-11-06 The Regents Of The University Of California Method for determining differences in molecular interactions and for screening a combinatorial library
US20040171062A1 (en) * 2002-02-28 2004-09-02 Plexxikon, Inc. Methods for the design of molecular scaffolds and ligands
DK1487978T3 (da) 2002-03-15 2009-03-23 Nuevolution As Forbedret fremgangsmåde til syntese af templatemolekyler
EP1494695A4 (de) * 2002-04-15 2006-01-25 American Nat Red Cross Plasmaprotein-bindungsliganden
US20070015230A1 (en) * 2002-04-15 2007-01-18 Hammond David J Identification and characterization of analytes from whole blood
AU2003247610A1 (en) * 2002-06-21 2004-01-06 Ptc Therapeutics, Inc. METHODS FOR IDENTIFYING SMALL MOLECULES THAT MODULATE PREMATURE TRANSLATION TERMINATION AND NONSENSE MEDIATED mRNA DECAY
US7927791B2 (en) * 2002-07-24 2011-04-19 Ptc Therapeutics, Inc. Methods for identifying small molecules that modulate premature translation termination and nonsense mediated mRNA decay
AU2003247266A1 (en) * 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
CA2503905A1 (en) * 2002-09-16 2004-03-25 Plexxikon, Inc. Crystal structure of pim-1 kinase
EP1545762A2 (de) * 2002-09-27 2005-06-29 Carlsberg A/S Räumlich kodierte polymermatrix
DK2348124T3 (en) 2002-10-30 2014-03-10 Nuevolution As Synthesis of a bifunctional complex
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
ES2545619T3 (es) 2003-01-31 2015-09-14 The Mount Sinai School Of Medicine Of New York University Terapia de combinación para tratar trastornos de deficiencia de proteínas
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US20060269920A1 (en) * 2003-02-21 2006-11-30 Nuevolution A/S Method for obtaining structural information about an encoded molecule
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
US20050170431A1 (en) * 2003-02-28 2005-08-04 Plexxikon, Inc. PYK2 crystal structure and uses
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
AU2004259738B2 (en) 2003-07-17 2011-11-17 Plexxikon, Inc. PPAR active compounds
US7348338B2 (en) * 2003-07-17 2008-03-25 Plexxikon, Inc. PPAR active compounds
US20050164300A1 (en) * 2003-09-15 2005-07-28 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
WO2005026387A1 (en) * 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
ES2375962T3 (es) 2003-09-22 2012-03-07 Bioarray Solutions Ltd Polielectrolito inmovilizado en superficie con múltiples grupos funcionales capaces de unirse covalentemente a biomoléculas.
EP1692298A4 (de) 2003-10-28 2008-08-13 Bioarray Solutions Ltd Optimierung der genexpressionsanalyse unter verwendung immobilisierter fängersonden
ES2533876T3 (es) 2003-10-29 2015-04-15 Bioarray Solutions Ltd Análisis multiplexado de ácidos nucleicos mediante fragmentación de ADN bicatenario
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
PL1696920T3 (pl) * 2003-12-19 2015-03-31 Plexxikon Inc Związki i sposoby opracowywania modulatorów Ret
EP1723255B1 (de) * 2004-02-17 2010-12-29 Nuevolution A/S Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP1742627A4 (de) 2004-05-06 2009-08-26 Plexxikon Inc Pde4b-hemmer und ihre verwendung
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US7605168B2 (en) * 2004-09-03 2009-10-20 Plexxikon, Inc. PDE4B inhibitors
WO2006060456A2 (en) * 2004-11-30 2006-06-08 Plexxikon, Inc. Indole derivatives for use as ppar ppar active compounds
US20060160135A1 (en) * 2004-12-08 2006-07-20 Weiru Wang SF-1 and LRH-1 modulator development
AU2006272951A1 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US20070021433A1 (en) 2005-06-03 2007-01-25 Jian-Qiang Fan Pharmacological chaperones for treating obesity
DK1893612T3 (da) * 2005-06-22 2011-11-21 Plexxikon Inc Pyrrol [2,3-B]pyridin-derivater som proteinkinasehæmmere
CN101437539B (zh) 2005-07-05 2013-10-02 康奈尔研究基金会(有限公司) 通过干扰cd99l2阻断白细胞迁出和炎症
RU2419618C2 (ru) * 2005-09-07 2011-05-27 Плекссикон, Инк. Соединения, активные в отношении ppar (рецепторов активаторов пролиферации пероксисом)
WO2007037706A2 (en) * 2005-09-27 2007-04-05 Bernd Helmut Adam Rehm Polymer particles and uses thereof
EP2341140B1 (de) * 2005-12-01 2017-07-19 Nuevolution A/S Enzymvermittelnde Kodierungsmethoden für eine effiziente Synthese von grossen Bibliotheken
EP2074230B1 (de) 2006-10-11 2012-11-28 Janssen Pharmaceutica NV Zusammensetzungen und verfahren zur behandlung und diagnose von reizkolon
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
EP2094701A2 (de) 2006-12-21 2009-09-02 Plexxikon, Inc. Verbindungen und verfahren zur kinase-modulation und anzeigen dafür
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
PE20090159A1 (es) * 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
MX2010000617A (es) 2007-07-17 2010-05-17 Plexxikon Inc Compuestos y metodos para modulacion de cinasa, e indicaciones de estos.
EA021797B1 (ru) 2009-02-13 2015-09-30 Икс-Чем, Инк. Способы создания и скрининга библиотек, кодируемых днк
WO2010114928A2 (en) * 2009-04-03 2010-10-07 F.Hoffmann-La Roche Ag Compositions and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
NZ629615A (en) 2009-11-06 2016-01-29 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
LT2558577T (lt) 2010-04-16 2019-03-12 Nuevolution A/S Bifunkciniai kompleksai ir tokių kompleksų gamybos ir naudojimo būdai
JP5941069B2 (ja) 2011-02-07 2016-06-29 プレキシコン インコーポレーテッドPlexxikon Inc. キナーゼ調節のための化合物および方法、ならびにそれに対する適応症
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
CA2848023C (en) 2011-09-07 2022-03-15 X-Chem, Inc. Methods for tagging dna-encoded libraries
EP2776579B1 (de) 2011-11-07 2019-05-01 The Broad Institute, Inc. Propeptidluciferase-fusionsproteine und verfahren zu ihrer anwendung
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
NZ703766A (en) 2012-07-13 2018-03-23 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
SG11201506875YA (en) 2013-03-15 2015-09-29 Intrexon Corp Boron-containing diacylhydrazines
EP3194359B1 (de) 2014-09-17 2020-04-08 Intrexon Corporation Borhaltige diacylhydrazinverbindungen
CA3001065A1 (en) 2015-10-14 2017-04-20 Xiaoxi WEI Compositions and methods for reducing ice crystal formation
US10993995B2 (en) 2015-12-07 2021-05-04 Erasmus University Medical Center Rotterdam Enzymatic replacement therapy and antisense therapy for pompe disease
EP3243857A1 (de) * 2016-05-13 2017-11-15 Centre National de la Recherche Scientifique - CNRS - Gleichmässige sequenzdefinierte polyurethane und verwendungen davon als molekulare etiketten
NL2017294B1 (en) 2016-08-05 2018-02-14 Univ Erasmus Med Ct Rotterdam Natural cryptic exon removal by pairs of antisense oligonucleotides.
MX2019012398A (es) 2017-04-18 2020-09-25 Broad Inst Inc Composiciones para detectar secreciones y metodos de uso.

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5182366A (en) * 1990-05-15 1993-01-26 Huebner Verena D Controlled synthesis of peptide mixtures using mixed resins
IE66205B1 (en) * 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5475085A (en) * 1991-02-07 1995-12-12 Molecumetics, Ltd. Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
US5449754A (en) * 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
WO1993002992A1 (en) * 1991-08-07 1993-02-18 H & N Instruments, Inc. Synthesis of chain chemical compounds
AU669489B2 (en) * 1991-09-18 1996-06-13 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5395750A (en) * 1992-02-28 1995-03-07 Hoffmann-La Roche Inc. Methods for producing proteins which bind to predetermined antigens
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
EP0665897B1 (de) * 1992-10-01 2003-07-09 The Trustees Of Columbia University In The City Of New York Komplexe kombinatorische chemische banken, die mit markierungen versehen sind
US5228514A (en) * 1992-11-19 1993-07-20 Ruska Laboratories, Inc. Gas trap apparatus
US5840485A (en) * 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
US5480971A (en) * 1993-06-17 1996-01-02 Houghten Pharmaceuticals, Inc. Peralkylated oligopeptide mixtures
IL106106A0 (en) * 1993-06-22 1993-10-20 Interpharm Lab Ltd Library of polymeric molecules and its preparation
US5463564A (en) * 1994-09-16 1995-10-31 3-Dimensional Pharmaceuticals, Inc. System and method of automatically generating chemical compounds with desired properties

Also Published As

Publication number Publication date
JPH09501490A (ja) 1997-02-10
DK0705279T3 (da) 2003-06-10
NZ267843A (en) 1997-10-24
CA2163637C (en) 2008-05-06
DE69434998T2 (de) 2008-03-13
AU686186B2 (en) 1998-02-05
DK1310510T3 (da) 2007-09-24
DE69432147D1 (de) 2003-03-27
ATE366741T1 (de) 2007-08-15
CA2163637A1 (en) 1994-12-08
DE69434998D1 (de) 2007-08-23
PT705279E (pt) 2003-07-31
EP0705279B1 (de) 2003-02-19
EP0705279A1 (de) 1996-04-10
AU7048694A (en) 1994-12-20
ATE232882T1 (de) 2003-03-15
US6090912A (en) 2000-07-18
ES2289194T3 (es) 2008-02-01
JP3394777B2 (ja) 2003-04-07
ES2204921T3 (es) 2004-05-01
EP0705279A4 (de) 1999-03-24
WO1994028028A1 (en) 1994-12-08

Similar Documents

Publication Publication Date Title
DE69432147D1 (de) Topologisch getrennte kodierende festphasen-bibliotheken
EP1310510A3 (de) Topologisch getrennte kodierende festphasen-bibliotheken
DE69626621D1 (de) Synthese von n-substituierten oligomeren
Bochicchio et al. Investigating by CD the molecular mechanism of elasticity of elastomeric proteins
FI951356A (fi) N-substituoitujen oligomeerien synteesi
ATE176239T1 (de) Synthese äquimolarer mischungen vielzähliger oligomere, speziell oligopeptidmischungen
BR9810613A (pt) Composição poliisocianato, e, processo para preparar uma espuma de poliuretano
MX10917A (es) Una resina sintetica y procedimiento para su preparacion
Griffiths et al. Site‐Selective Installation of Nϵ‐Modified Sidechains into Peptide and Protein Scaffolds via Visible‐Light‐Mediated Desulfurative C–C Bond Formation
Wu et al. Rapid Access to Multiple Classes of Peptidomimetics from Common γ‐AApeptide Building Blocks
Hyde et al. Internal aggregation during solid phase peptide synthesis. Dimethyl sulfoxide as a powerful dissociating solvent
Zhu et al. A family of single‐isomer, sulfated γ‐cyclodextrin chiral resolving agents for capillary electrophoresis: Octa (6‐O‐sulfo)‐γ‐cyclodextrin
Maruyama et al. Effects of hydrogen bonding and side‐chain conformation on the Raman bands of tryptophan‐2, 4, 5, 6, 7‐d5
Semetey et al. Unexpected stability of the urea cis− trans isomer in urea-containing model pseudopeptides
Petracca et al. Chemoselective synthesis of N-terminal cysteinyl thioesters via β, γ-C, S thiol-michael addition
Hill et al. Disuccinimidyl esters as bifunctional crosslinking reagents for proteins: assays with myosin
Shirazian et al. The gas-phase conformations of valine: an ab initio study
Andersson et al. Molecular imprinting of the endogenous neuropeptide Leu5‐enkephalin and some derivatives thereof
Bianco et al. Multistep synthesis of 2, 5-diketopiperazines on different solid supports monitored by high resolution magic angle spinning NMR spectroscopy
Brahmachary et al. Chiral recognition: Design and preparation of chiral stationary phases using selectors derived from Ugi multicomponent condensation reactions and a combinatorial approach
ATE242202T1 (de) Peptide
Labroo et al. Direct photochemical trifluoromethylation of histidine-containing peptides
Van de Langemheen et al. Scaffolded multiple cyclic peptide libraries for protein mimics by native chemical ligation
Cradock et al. Electron diffraction investigation of the molecular structures of isopropyl isocyanate and isopropyl isothiocyanate
Ananda et al. Convenient and efficient synthesis of Boc‐/Z‐/Fmoc‐β‐amino acids employingN‐protected α‐amino acid fluorides

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMACEUTICALS INC. (N.D.GES.D.STAATES DE

8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS HOLDINGS INC., GREENVILLE, DEL., US

8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US