DE69435044D1 - Rapamycin - Konjugate und Antikörper - Google Patents
Rapamycin - Konjugate und AntikörperInfo
- Publication number
- DE69435044D1 DE69435044D1 DE69435044T DE69435044T DE69435044D1 DE 69435044 D1 DE69435044 D1 DE 69435044D1 DE 69435044 T DE69435044 T DE 69435044T DE 69435044 T DE69435044 T DE 69435044T DE 69435044 D1 DE69435044 D1 DE 69435044D1
- Authority
- DE
- Germany
- Prior art keywords
- antibodies
- rapamycin conjugates
- rapamycin
- conjugates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5303093A | 1993-04-23 | 1993-04-23 | |
US53030 | 1993-04-23 | ||
US22420594A | 1994-04-14 | 1994-04-14 | |
US224205 | 1994-04-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69435044D1 true DE69435044D1 (de) | 2007-12-27 |
DE69435044T2 DE69435044T2 (de) | 2008-09-18 |
Family
ID=26731364
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435044T Expired - Lifetime DE69435044T2 (de) | 1993-04-23 | 1994-04-22 | Rapamycin - Konjugate und Antikörper |
DE69430060T Expired - Lifetime DE69430060T2 (de) | 1993-04-23 | 1994-04-22 | Antikörper von rapamycinen mit offenem ring |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69430060T Expired - Lifetime DE69430060T2 (de) | 1993-04-23 | 1994-04-22 | Antikörper von rapamycinen mit offenem ring |
Country Status (8)
Country | Link |
---|---|
US (2) | US6328970B1 (de) |
EP (2) | EP0710110B1 (de) |
JP (3) | JPH08509499A (de) |
AU (1) | AU686629B2 (de) |
CA (1) | CA2161101A1 (de) |
DE (2) | DE69435044T2 (de) |
ES (2) | ES2176245T3 (de) |
WO (1) | WO1994025022A1 (de) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
US7279561B1 (en) * | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
DE69435044T2 (de) | 1993-04-23 | 2008-09-18 | Wyeth | Rapamycin - Konjugate und Antikörper |
KR100361933B1 (ko) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
US6709873B1 (en) | 1997-04-09 | 2004-03-23 | Isodiagnostika Inc. | Method for production of antibodies to specific sites of rapamycin |
US7078495B1 (en) * | 1999-08-03 | 2006-07-18 | Dade Behring Inc. | Monoclonal antibodies to tacrolimus and immunoassay methods for tacrolimus |
EP1212331B1 (de) | 1999-08-24 | 2004-04-21 | Ariad Gene Therapeutics, Inc. | 28-epirapaloge |
US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
DE60231868D1 (de) * | 2001-04-24 | 2009-05-20 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
CN101717410B (zh) * | 2002-02-01 | 2015-04-29 | 阿里亚德医药股份有限公司 | 含磷化合物及其应用 |
AU2003243226A1 (en) * | 2002-05-15 | 2003-12-02 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
EP2517730A3 (de) | 2003-01-27 | 2013-01-02 | Endocyte, Inc. | Vitaminrezeptorbindende Wirkstofffreisetzungskonjugate |
US9114198B2 (en) * | 2003-11-19 | 2015-08-25 | Advanced Cardiovascular Systems, Inc. | Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same |
ES2425167T3 (es) * | 2004-03-10 | 2013-10-11 | Seradyn, Inc. | Inmunoensayos para everolimús |
MXPA06011882A (es) * | 2004-04-14 | 2006-12-14 | Wyeth Corp | Procedimiento para preparar 42-esteres de rapamicina y 32-esteres de fk 506 con acido dicarboxilico, precursores para conjugados de rapamicina y anticuerpos. |
JP5149620B2 (ja) | 2004-07-23 | 2013-02-20 | エンドサイト,インコーポレイテッド | 2価リンカーおよびその結合体 |
BRPI0514206A (pt) * | 2004-08-10 | 2008-06-03 | Wyeth Corp | composto, anticorpo, kit para monitorar a terapia com cci-779, e, métodos para detectar metabólitos de cci-779, e para produzir um metabólito sintético e um derivado de cci-779 |
US8021849B2 (en) | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
RU2007119585A (ru) | 2004-12-20 | 2009-01-27 | Вайет (Us) | Производные рапамицина и их применение при лечении неврологических заболеваний |
AU2005319454B2 (en) | 2004-12-20 | 2012-08-09 | Wyeth | Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders |
JP5289935B2 (ja) * | 2005-03-16 | 2013-09-11 | エンドサイト,インコーポレイテッド | プテロイン酸およびその結合体の合成と精製 |
US7189582B2 (en) | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
JP2009504783A (ja) * | 2005-08-19 | 2009-02-05 | エンドサイト,インコーポレイテッド | ビンカアルカロイド、類似体および誘導体のリガンド結合体 |
RU2470668C2 (ru) * | 2005-08-19 | 2012-12-27 | Эндосайт, Инк. | Конъюгаты лиганда с несколькими лекарственными средствами |
CN102579467A (zh) | 2005-11-14 | 2012-07-18 | 阿里亚德医药股份有限公司 | 雷帕霉素衍生物在治疗癌症中的用途 |
US7883855B2 (en) | 2006-07-21 | 2011-02-08 | Abbott Laboratories | Immunosuppressant drug extraction reagent for immunoassays |
CA2669415A1 (en) | 2006-11-14 | 2008-05-22 | Ariad Pharmaceuticals, Inc. | Solid dosage form comprising ap23573 |
US8998846B2 (en) | 2006-11-20 | 2015-04-07 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US8430055B2 (en) | 2008-08-29 | 2013-04-30 | Lutonix, Inc. | Methods and apparatuses for coating balloon catheters |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414910B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414526B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US8425459B2 (en) | 2006-11-20 | 2013-04-23 | Lutonix, Inc. | Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent |
US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
WO2008065887A1 (fr) | 2006-11-27 | 2008-06-05 | Terumo Kabushiki Kaisha | Procédé de fabrication d'un dérivé de rapamycine o-alkylé, et dérivé de rapamycine o-alkylée |
ES2393135T3 (es) | 2006-12-29 | 2012-12-18 | Abbott Laboratories | Ensayo mejorado para fármacos inmunosupresores |
US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
EP2118657B1 (de) | 2006-12-29 | 2014-05-21 | Abbott Laboratories | Nichtdenaturierendes lysereagens zur verwendung mit einem capture-in-solution-immunoassay |
CA2672972C (en) | 2006-12-29 | 2015-06-23 | Abbott Laboratories | Diagnostic test for the detection of a molecule or drug in whole blood |
US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
CN103948937A (zh) * | 2007-03-14 | 2014-07-30 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
JP2010523566A (ja) * | 2007-04-05 | 2010-07-15 | ワイス エルエルシー | ワートマニン−ラパマイシンコンジュゲートおよびその使用 |
TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
RU2523909C2 (ru) * | 2007-06-25 | 2014-07-27 | Эндосайт, Инк. | Конъюгаты, содержащие гидрофильные спейсеры линкеров |
US9187521B2 (en) | 2007-10-25 | 2015-11-17 | Endocyte, Inc. | Tubulysins and processes for preparing |
WO2009089549A1 (en) | 2008-01-11 | 2009-07-16 | Massachusetts Eye & Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
CN101676291B (zh) * | 2008-09-18 | 2012-05-09 | 上海海和药物研究开发有限公司 | 一类雷帕霉素碳酸酯类似物、其药物组合物及其制备方法和用途 |
EP2329816B1 (de) * | 2009-11-26 | 2016-04-13 | National Taiwan University | Antikrebs-Wirkstoff aus Antrodia camphorata, Herstellungsverfahren und Verwendung dafür |
JP6195846B2 (ja) | 2012-01-27 | 2017-09-13 | ノボ・ノルデイスク・エー/エス | スライド目盛りを備える注射装置 |
US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
WO2014062697A2 (en) | 2012-10-16 | 2014-04-24 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
US9121859B2 (en) | 2012-12-04 | 2015-09-01 | Siemens Healthcare Diagnostics Inc. | Compounds and methods for determination of FKBP-binding immunosuppressant drugs |
JP6525971B2 (ja) | 2013-06-11 | 2019-06-05 | タカラ バイオ ユーエスエー, インコーポレイテッド | タンパク質富化微細小胞、タンパク質富化微細小胞の作製方法及び使用方法 |
TW201511785A (zh) | 2013-07-17 | 2015-04-01 | Sanofi Sa | 顯示器總成及施配裝置 |
US10682415B2 (en) | 2013-07-22 | 2020-06-16 | Wisconsin Alumni Research Foundation | Thermogel formulation for combination drug delivery |
CN105461738B (zh) * | 2014-06-03 | 2019-03-08 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种雷帕霉素衍生物、其制备方法、其药物组合物及用途 |
EP3310786B1 (de) * | 2015-06-16 | 2021-03-03 | Nanophagix LLC | Chemisches konjugat für wirkstofffreisetzung und bildgebung, formulierungen und verfahren zur verwendung davon |
US10456477B2 (en) * | 2016-03-14 | 2019-10-29 | Wisconsin Alumni Research Foundation | Oligolactic acid conjugates and micelles with enhanced anticancer efficacy |
Family Cites Families (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US3993749A (en) | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
US4885171A (en) | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4401653A (en) | 1981-03-09 | 1983-08-30 | Ayerst, Mckenna & Harrison Inc. | Combination of rapamycin and picibanil for the treatment of tumors |
US5169773A (en) | 1984-10-04 | 1992-12-08 | Sandoz Ltd. | Monoclonal antibodies to cyclosporins |
EP0201751A2 (de) * | 1985-05-08 | 1986-11-20 | Abbott Laboratories | 4-Aminomethylfluoreszeinderivate zur Verwendung in Fluoreszenz-Polarisationsimmunotesten |
US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
EP0238801A1 (de) | 1986-02-19 | 1987-09-30 | Siemens Aktiengesellschaft | Mehrpolige elektrische Steckverbindung |
EP0283801A3 (de) | 1987-03-27 | 1990-05-30 | Abbott Laboratories | Fluoreszenz-Polarisations-Test für Cyclosporin A und Metaboliten und verwandte Immunogene und Antikörper |
DE3886265T2 (de) | 1987-06-05 | 1994-04-28 | Fujisawa Pharmaceutical Co | Anti-FR-900506-Stoffe-Antikörper und höchstempfindliches Enzym-Immunoassay-Verfahren. |
US5089390A (en) | 1987-09-04 | 1992-02-18 | Syntex (U.S.A.) Inc. | 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives |
JPH0633315B2 (ja) * | 1988-01-25 | 1994-05-02 | ベーリンガー・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | ハプテン誘導体、その製法、ハプテン/蛋白質―接合体、その製法、抗体の製法及びイムノアッセイの標識酵素 |
AU4958590A (en) | 1988-12-05 | 1990-07-10 | Trustees Of Columbia University In The City Of New York, The | Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof |
CA2045673A1 (en) | 1989-01-30 | 1990-07-31 | Stefan Gavojdea | Detection of antibodies in body fluids for diagnostic testing |
US5100899A (en) | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5122511A (en) | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
US5023264A (en) * | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
ES2084069T3 (es) | 1990-08-15 | 1996-05-01 | Abbott Lab | Reactivos de inmunoensayo y metodo para la determinacion de ciclosporina. |
PT98990A (pt) * | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
US5130307A (en) | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
US5233036A (en) * | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
DE69121844T2 (de) | 1990-11-20 | 1997-01-23 | Behringwerke Ag | Immunotest für Cyclosporin |
US5078999A (en) | 1991-02-22 | 1992-01-07 | American Home Products Corporation | Method of treating systemic lupus erythematosus |
US5080899A (en) | 1991-02-22 | 1992-01-14 | American Home Products Corporation | Method of treating pulmonary inflammation |
US5225543A (en) | 1991-03-28 | 1993-07-06 | American Cyanamid Company | Receptors method for purification of g protein-linked |
US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
IL101353A0 (en) | 1991-04-03 | 1992-11-15 | American Home Prod | Pharmaceutical compositions for treating diabetes |
US5100883A (en) | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
US5194447A (en) | 1992-02-18 | 1993-03-16 | American Home Products Corporation | Sulfonylcarbamates of rapamycin |
US5118678A (en) | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
US5091389A (en) | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
US5138051A (en) | 1991-08-07 | 1992-08-11 | American Home Products Corporation | Rapamycin analogs as immunosuppressants and antifungals |
US5102876A (en) | 1991-05-07 | 1992-04-07 | American Home Products Corporation | Reduction products of rapamycin |
US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
US6287792B1 (en) | 1991-06-17 | 2001-09-11 | The Regents Of The University Of California | Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology |
DK0525960T3 (da) | 1991-06-18 | 1996-04-15 | American Home Prod | Anvendelse af rapamycin til behandling af T-celle leukæmi/lymfon |
US5169851A (en) | 1991-08-07 | 1992-12-08 | American Home Products Corporation | Rapamycin analog as immunosuppressants and antifungals |
US5164495A (en) * | 1991-09-18 | 1992-11-17 | Abbott Laboratories | Method for preparing a dicarboxylic acid half-acid ester of FK506 |
US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
US5177203A (en) * | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
WO1993019752A1 (en) * | 1992-04-07 | 1993-10-14 | Dana-Farber Cancer Institute, Inc. | Inhibition of p70 s6 kinase |
AU4400593A (en) * | 1992-06-05 | 1994-01-04 | Abbott Laboratories | Methods and reagents for the determination of immunosuppressive agents |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5252579A (en) | 1993-02-16 | 1993-10-12 | American Home Products Corporation | Macrocyclic immunomodulators |
GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
US5504091A (en) | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
DE69435044T2 (de) | 1993-04-23 | 2008-09-18 | Wyeth | Rapamycin - Konjugate und Antikörper |
US6187547B1 (en) | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
US5378836A (en) * | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
US5391730A (en) * | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
DK0734389T3 (da) | 1993-12-17 | 2000-08-21 | Novartis Ag | Rapamycinderivater, som er anvendelige som immunosuppressive midler |
PL184731B1 (pl) | 1995-06-09 | 2002-12-31 | Novartis Ag | Pochodne rapamycyny, zastosowanie pochodnych rapamycyny i kompozycja farmaceutyczna |
-
1994
- 1994-04-22 DE DE69435044T patent/DE69435044T2/de not_active Expired - Lifetime
- 1994-04-22 CA CA002161101A patent/CA2161101A1/en not_active Abandoned
- 1994-04-22 WO PCT/US1994/004434 patent/WO1994025022A1/en active IP Right Grant
- 1994-04-22 JP JP6524408A patent/JPH08509499A/ja active Pending
- 1994-04-22 EP EP94915854A patent/EP0710110B1/de not_active Expired - Lifetime
- 1994-04-22 AU AU67720/94A patent/AU686629B2/en not_active Expired
- 1994-04-22 ES ES94915854T patent/ES2176245T3/es not_active Expired - Lifetime
- 1994-04-22 EP EP01120777A patent/EP1181938B1/de not_active Expired - Lifetime
- 1994-04-22 DE DE69430060T patent/DE69430060T2/de not_active Expired - Lifetime
- 1994-04-22 ES ES01120777T patent/ES2295093T3/es not_active Expired - Lifetime
-
2000
- 2000-05-24 US US09/576,952 patent/US6328970B1/en not_active Expired - Fee Related
-
2001
- 2001-02-02 US US09/773,562 patent/US6541612B2/en not_active Expired - Fee Related
-
2003
- 2003-12-10 JP JP2003412072A patent/JP2004149542A/ja active Pending
- 2003-12-10 JP JP2003412071A patent/JP2004168782A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU686629B2 (en) | 1998-02-12 |
EP1181938A3 (de) | 2002-03-20 |
US6328970B1 (en) | 2001-12-11 |
EP0710110A1 (de) | 1996-05-08 |
ES2176245T3 (es) | 2002-12-01 |
DE69430060D1 (de) | 2002-04-11 |
JP2004168782A (ja) | 2004-06-17 |
EP0710110B1 (de) | 2002-03-06 |
US20010010920A1 (en) | 2001-08-02 |
DE69435044T2 (de) | 2008-09-18 |
EP1181938A2 (de) | 2002-02-27 |
JP2004149542A (ja) | 2004-05-27 |
WO1994025022A1 (en) | 1994-11-10 |
DE69430060T2 (de) | 2002-11-07 |
CA2161101A1 (en) | 1994-11-10 |
US6541612B2 (en) | 2003-04-01 |
AU6772094A (en) | 1994-11-21 |
ES2295093T3 (es) | 2008-04-16 |
EP0710110A4 (de) | 1997-06-18 |
EP1181938B1 (de) | 2007-11-14 |
JPH08509499A (ja) | 1996-10-08 |
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