DE69435261D1 - Menschlicher rezeptor h4-1bb - Google Patents
Menschlicher rezeptor h4-1bbInfo
- Publication number
- DE69435261D1 DE69435261D1 DE69435261T DE69435261T DE69435261D1 DE 69435261 D1 DE69435261 D1 DE 69435261D1 DE 69435261 T DE69435261 T DE 69435261T DE 69435261 T DE69435261 T DE 69435261T DE 69435261 D1 DE69435261 D1 DE 69435261D1
- Authority
- DE
- Germany
- Prior art keywords
- receptor protein
- human
- protein
- cells
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108020003175 receptors Proteins 0.000 abstract 8
- 102000005962 receptors Human genes 0.000 abstract 8
- 239000002299 complementary DNA Substances 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 3
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 abstract 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000006052 T cell proliferation Effects 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12279693A | 1993-09-16 | 1993-09-16 | |
PCT/US1994/010457 WO1995007984A1 (en) | 1993-09-16 | 1994-09-15 | Human receptor h4-1bb |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69435261D1 true DE69435261D1 (de) | 2010-02-25 |
Family
ID=22404839
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435261T Expired - Lifetime DE69435261D1 (de) | 1993-09-16 | 1994-09-15 | Menschlicher rezeptor h4-1bb |
Country Status (11)
Country | Link |
---|---|
US (3) | US8026353B2 (de) |
EP (1) | EP0719329B1 (de) |
JP (2) | JPH09503911A (de) |
KR (2) | KR100244960B1 (de) |
AT (1) | ATE454449T1 (de) |
AU (1) | AU697482B2 (de) |
CA (2) | CA2429027C (de) |
DE (1) | DE69435261D1 (de) |
ES (1) | ES2341631T3 (de) |
NZ (1) | NZ273838A (de) |
WO (1) | WO1995007984A1 (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6362325B1 (en) | 1988-11-07 | 2002-03-26 | Advanced Research And Technology Institute, Inc. | Murine 4-1BB gene |
US6303121B1 (en) | 1992-07-30 | 2001-10-16 | Advanced Research And Technology | Method of using human receptor protein 4-1BB |
US7211259B1 (en) | 1993-05-07 | 2007-05-01 | Immunex Corporation | 4-1BB polypeptides and DNA encoding 4-1BB polypeptides |
US7138500B1 (en) | 1993-05-07 | 2006-11-21 | Immunex Corporation | Antibodies to human 4-1BB |
ATE454449T1 (de) | 1993-09-16 | 2010-01-15 | Univ Indiana Res & Tech Corp | Menschlicher rezeptor h4-1bb |
US5928893A (en) * | 1995-04-08 | 1999-07-27 | Lg Chemical Ltd. | Monoclonal antibody specific for human 4-1BB and cell line producing same |
WO1997033898A1 (en) * | 1996-03-15 | 1997-09-18 | Human Genome Sciences, Inc. | Human 4-1bb receptor splicing variant |
US5874240A (en) * | 1996-03-15 | 1999-02-23 | Human Genome Sciences, Inc. | Human 4-1BB receptor splicing variant |
CN1232402A (zh) * | 1996-10-11 | 1999-10-20 | 布里斯托尔-迈尔斯斯奎布公司 | 免疫调节的方法和组合物 |
AU747063B2 (en) * | 1998-03-05 | 2002-05-09 | Merckle Gmbh | Utilization of CD137 in order to promote the proliferation of peripheral monocytes |
AU784634B2 (en) | 1999-11-30 | 2006-05-18 | Mayo Foundation For Medical Education And Research | B7-H1, a novel immunoregulatory molecule |
ES2328025T3 (es) | 2001-10-09 | 2009-11-06 | Mayo Foundation For Medical Education And Research | Mejoramiento de las respuestas inmunitarias por anticuerpos agonistas 4-1 bb. |
JP2005536511A (ja) * | 2002-07-15 | 2005-12-02 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | 4−1bb結合物質を用いる治療及び予防 |
US20060121030A1 (en) * | 2002-12-16 | 2006-06-08 | Herbert Schwarz | Use of cd 137 antagonists for the treatment of tumors |
US7288638B2 (en) | 2003-10-10 | 2007-10-30 | Bristol-Myers Squibb Company | Fully human antibodies against human 4-1BB |
US20070253961A1 (en) * | 2004-06-09 | 2007-11-01 | Ulsan Industrial Education Foundation | Pharmaceutical Composition Comprising the Anti-4-1Bb Antibody for Treating or Preventing Rheumatoid Arthritis |
JP5303146B2 (ja) | 2004-10-06 | 2013-10-02 | メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ | B7−h1ならびに癌の診断、予後診断および処置の方法 |
US20060182744A1 (en) * | 2005-02-15 | 2006-08-17 | Strome Scott E | Anti-CD137 antibody as an agent in the treatment of cancer and glycosylation variants thereof |
US20080019905A9 (en) * | 2005-02-18 | 2008-01-24 | Strome Scott E | Method of using an anti-CD137 antibody as an agent for radioimmunotherapy or radioimmunodetection |
NZ568433A (en) * | 2005-10-21 | 2012-07-27 | Gtc Biotherapeutics Inc | Milk-derived antibodies with enhanced antibody-dependent cellular cytoxicity activity, methods of their production and use |
US20110229460A1 (en) * | 2008-05-01 | 2011-09-22 | Gtc Biotherapeutics, Inc. | anti-cd137 antibody as an agent in the treatment of inflammatory conditions |
US8475790B2 (en) | 2008-10-06 | 2013-07-02 | Bristol-Myers Squibb Company | Combination of CD137 antibody and CTLA-4 antibody for the treatment of proliferative diseases |
JPWO2011149025A1 (ja) * | 2010-05-28 | 2013-07-25 | 株式会社上野忠 | 経口用体温上昇剤 |
MY169644A (en) * | 2010-12-09 | 2019-04-24 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
CA2824997C (en) | 2011-01-18 | 2023-01-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
WO2015050663A1 (en) | 2013-10-01 | 2015-04-09 | Mayo Foundation For Medical Education And Research | Methods for treating cancer in patients with elevated levels of bim |
CN111514283A (zh) | 2014-04-07 | 2020-08-11 | 诺华股份有限公司 | 使用抗cd19嵌合抗原受体治疗癌症 |
US10302653B2 (en) | 2014-05-22 | 2019-05-28 | Mayo Foundation For Medical Education And Research | Distinguishing antagonistic and agonistic anti B7-H1 antibodies |
EP3171896A4 (de) | 2014-07-23 | 2018-03-21 | Mayo Foundation for Medical Education and Research | Abzielung auf dna-pkcs und b7-h1 zur behandlung von krebs |
EP4056588A1 (de) | 2015-04-08 | 2022-09-14 | Novartis AG | Cd20-therapien, cd22-therapien und kombinationstherapien mit einer zelle zur expression des chimären antigen-rezeptors (car) cd19 |
WO2017075045A2 (en) | 2015-10-30 | 2017-05-04 | Mayo Foundation For Medical Education And Research | Antibodies to b7-h1 |
MX2019003886A (es) | 2016-10-07 | 2019-08-05 | Novartis Ag | Receptores de antigenos quimericos para el tratamiento del cancer. |
AU2018209452A1 (en) | 2017-01-20 | 2019-07-18 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD137+ cells |
AU2018301393A1 (en) | 2017-07-11 | 2020-02-06 | Compass Therapeutics Llc | Agonist antibodies that bind human CD137 and uses thereof |
US11718679B2 (en) | 2017-10-31 | 2023-08-08 | Compass Therapeutics Llc | CD137 antibodies and PD-1 antagonists and uses thereof |
WO2019100052A2 (en) | 2017-11-20 | 2019-05-23 | Compass Therapeutics Llc | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
WO2021170071A1 (en) | 2020-02-28 | 2021-09-02 | Shanghai Henlius Biotech, Inc. | Anti-cd137 constructs, multispecific antibody and uses thereof |
WO2021170067A1 (zh) | 2020-02-28 | 2021-09-02 | 上海复宏汉霖生物技术股份有限公司 | 抗cd137构建体及其用途 |
CN114605541B (zh) * | 2021-08-26 | 2023-08-29 | 北京大学深圳研究生院 | 一种抗4-1bb纳米抗体、编码基因及应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4560649A (en) | 1981-10-15 | 1985-12-24 | Cornell Research Foundation | Assaying for hLH or hCG with immobilized hormone receptors |
US4837306A (en) * | 1985-02-25 | 1989-06-06 | The Ontario Cancer Institute | Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen |
US6303121B1 (en) | 1992-07-30 | 2001-10-16 | Advanced Research And Technology | Method of using human receptor protein 4-1BB |
US5350836A (en) | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
US7138500B1 (en) * | 1993-05-07 | 2006-11-21 | Immunex Corporation | Antibodies to human 4-1BB |
AU6827094A (en) | 1993-05-07 | 1994-12-12 | Immunex Corporation | Cytokine designated 4-1bb ligand and human receptor that binds thereto |
US7211259B1 (en) * | 1993-05-07 | 2007-05-01 | Immunex Corporation | 4-1BB polypeptides and DNA encoding 4-1BB polypeptides |
ATE454449T1 (de) | 1993-09-16 | 2010-01-15 | Univ Indiana Res & Tech Corp | Menschlicher rezeptor h4-1bb |
US5928893A (en) | 1995-04-08 | 1999-07-27 | Lg Chemical Ltd. | Monoclonal antibody specific for human 4-1BB and cell line producing same |
-
1994
- 1994-09-15 AT AT94928141T patent/ATE454449T1/de not_active IP Right Cessation
- 1994-09-15 ES ES94928141T patent/ES2341631T3/es not_active Expired - Lifetime
- 1994-09-15 AU AU77294/94A patent/AU697482B2/en not_active Expired
- 1994-09-15 EP EP94928141A patent/EP0719329B1/de not_active Expired - Lifetime
- 1994-09-15 CA CA2429027A patent/CA2429027C/en not_active Expired - Lifetime
- 1994-09-15 CA CA002172165A patent/CA2172165C/en not_active Expired - Lifetime
- 1994-09-15 WO PCT/US1994/010457 patent/WO1995007984A1/en active Application Filing
- 1994-09-15 KR KR1019960701385A patent/KR100244960B1/ko not_active IP Right Cessation
- 1994-09-15 DE DE69435261T patent/DE69435261D1/de not_active Expired - Lifetime
- 1994-09-15 NZ NZ273838A patent/NZ273838A/en not_active IP Right Cessation
- 1994-09-15 JP JP7509364A patent/JPH09503911A/ja active Pending
-
1999
- 1999-07-30 KR KR1019997007048A patent/KR100271382B1/ko not_active IP Right Cessation
-
2001
- 2001-12-20 US US10/027,199 patent/US8026353B2/en not_active Expired - Fee Related
-
2005
- 2005-12-21 JP JP2005368486A patent/JP2006149389A/ja active Pending
-
2006
- 2006-12-11 US US11/609,263 patent/US20070117161A1/en not_active Abandoned
-
2007
- 2007-10-17 US US11/873,784 patent/US20080312418A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2172165A1 (en) | 1995-03-23 |
KR100271382B1 (en) | 2000-11-15 |
AU7729494A (en) | 1995-04-03 |
CA2429027A1 (en) | 1995-03-23 |
WO1995007984A1 (en) | 1995-03-23 |
NZ273838A (en) | 1997-09-22 |
EP0719329B1 (de) | 2010-01-06 |
AU697482B2 (en) | 1998-10-08 |
CA2172165C (en) | 2003-12-02 |
US20070117161A1 (en) | 2007-05-24 |
US8026353B2 (en) | 2011-09-27 |
US20020168719A1 (en) | 2002-11-14 |
JP2006149389A (ja) | 2006-06-15 |
ES2341631T3 (es) | 2010-06-23 |
JPH09503911A (ja) | 1997-04-22 |
KR100244960B1 (ko) | 2000-02-15 |
ATE454449T1 (de) | 2010-01-15 |
EP0719329A1 (de) | 1996-07-03 |
CA2429027C (en) | 2011-04-05 |
US20080312418A1 (en) | 2008-12-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69435261D1 (de) | Menschlicher rezeptor h4-1bb | |
Blazar et al. | Recent advances in graft‐versus‐host disease (GVHD) prevention | |
Weiss et al. | The role of the T3/antigen receptor complex in T-cell activation. | |
Lane et al. | Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation. | |
Luescher et al. | CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes | |
US5747037A (en) | Anti-GP39 antibodies | |
Fangmann et al. | Rejection of skin allografts by indirect allorecognition of donor class I major histocompatibility complex peptides. | |
Mechtersheimer et al. | Expression of the natural killer cell-associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors | |
Bonnefoy et al. | The low-affinity receptor for IgE (CD23) on B lymphocytes is spatially associated with HLA-DR antigens. | |
AU784634B2 (en) | B7-H1, a novel immunoregulatory molecule | |
CA2246352A1 (en) | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith | |
Wade et al. | Structural compartmentalization of MHC class II signaling function | |
Bikah et al. | A role for CD5 in cognate interactions between T cells and B cells, and identification of a novel ligand for CD5. | |
KR940007179A (ko) | 시디40 (cd40)을 위한 수용성 리간드 | |
US20100015153A1 (en) | Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells and Antibodies That Identify the Same | |
JP2007126481A (ja) | T細胞の不応答性を調節する方法 | |
Lanier et al. | Natural killer cells | |
US20030044416A1 (en) | Nucleic acids encoding cd100 molecules | |
US7476385B2 (en) | Methods of inhibiting IgE responses to thymus-dependent antigens with the anti-gp39 antibody MR1 | |
Mortara et al. | Therapy‐induced antitumor vaccination by targeting tumor necrosis factor‐α to tumor vessels in combination with melphalan | |
EP0742721B1 (de) | Verfahren zur verlaengerter unterdrueckung der humoralen immunitaet | |
Rau et al. | MHC-restricted and-unrestricted CD8 T cells: an evolutionary perspective | |
AU2667701A (en) | Novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells, and antibodies that identify the same | |
Bromberg | The biology of CD2: adhesion, transmembrane signal, and regulatory receptor of immunity | |
Macphail et al. | L3T4+ cytotoxic T lymphocytes specific for class I H-2 antigens are activated in primary mixed lymphocyte reactions. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |