DE69503120D1 - Zusammensetzungen aus einer thrombolytisch wirkende substanz und antikoagulantien, und ihre verwendungen - Google Patents

Zusammensetzungen aus einer thrombolytisch wirkende substanz und antikoagulantien, und ihre verwendungen

Info

Publication number
DE69503120D1
DE69503120D1 DE69503120T DE69503120T DE69503120D1 DE 69503120 D1 DE69503120 D1 DE 69503120D1 DE 69503120 T DE69503120 T DE 69503120T DE 69503120 T DE69503120 T DE 69503120T DE 69503120 D1 DE69503120 D1 DE 69503120D1
Authority
DE
Germany
Prior art keywords
anticoagulant
thrombolytically
compositions
thrombolytically active
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69503120T
Other languages
English (en)
Other versions
DE69503120T3 (de
DE69503120T2 (de
Inventor
Ulrich Martin
Stephan Fischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Actavis Group PTC ehf
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22811809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69503120(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of DE69503120D1 publication Critical patent/DE69503120D1/de
Publication of DE69503120T2 publication Critical patent/DE69503120T2/de
Publication of DE69503120T3 publication Critical patent/DE69503120T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
DE69503120T 1994-03-25 1995-03-22 Zusammensetzungen aus einer thrombolytisch wirkende substanz und antikoagulantien, und ihre verwendungen Expired - Lifetime DE69503120T3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/217,618 US5510330A (en) 1994-03-25 1994-03-25 Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof.
PCT/EP1995/001061 WO1995026202A1 (en) 1994-03-25 1995-03-22 Combinations of thrombolytically active proteins and anticoagulants, and uses thereof

Publications (3)

Publication Number Publication Date
DE69503120D1 true DE69503120D1 (de) 1998-07-30
DE69503120T2 DE69503120T2 (de) 1998-11-12
DE69503120T3 DE69503120T3 (de) 2003-08-14

Family

ID=22811809

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69503120T Expired - Lifetime DE69503120T3 (de) 1994-03-25 1995-03-22 Zusammensetzungen aus einer thrombolytisch wirkende substanz und antikoagulantien, und ihre verwendungen

Country Status (21)

Country Link
US (1) US5510330A (de)
EP (2) EP0850648A3 (de)
JP (1) JPH09510439A (de)
KR (1) KR100366982B1 (de)
CN (1) CN1090029C (de)
AT (1) ATE167631T1 (de)
AU (1) AU702470B2 (de)
BR (1) BR9507189A (de)
CA (1) CA2186390A1 (de)
CZ (1) CZ279596A3 (de)
DE (1) DE69503120T3 (de)
DK (1) DK0751785T4 (de)
ES (1) ES2119411T5 (de)
FI (1) FI120182B (de)
MX (1) MX9603925A (de)
NO (1) NO316584B1 (de)
NZ (1) NZ282417A (de)
PL (1) PL182165B1 (de)
RU (1) RU2166326C2 (de)
UA (1) UA41398C2 (de)
WO (1) WO1995026202A1 (de)

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US7867275B2 (en) * 1995-06-07 2011-01-11 Cook Incorporated Coated implantable medical device method
US7846202B2 (en) 1995-06-07 2010-12-07 Cook Incorporated Coated implantable medical device
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
US7550005B2 (en) 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US20070203520A1 (en) * 1995-06-07 2007-08-30 Dennis Griffin Endovascular filter
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US5840733A (en) * 1996-07-01 1998-11-24 Redcell, Canada, Inc. Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6750201B1 (en) * 1997-10-17 2004-06-15 The Trustees Of The University Of Pennsylvania Compositions and methods for promoting internalization and degradation of urokinase-type plasminogen activator
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
FI20020197A0 (fi) * 2002-02-01 2002-02-01 Orion Corp Yhdistelmä akuutin myokardiilisen infarktin hoitoon
US7084118B2 (en) * 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
EP1521603B1 (de) 2002-07-12 2011-01-19 Cook Incorporated Beschichtete medizinische vorrichtung
DE10244847A1 (de) 2002-09-20 2004-04-01 Ulrich Prof. Dr. Speck Medizinische Vorrichtung zur Arzneimittelabgabe
AU2005248772B2 (en) * 2004-05-17 2010-11-25 Medtronic, Inc. Point of care heparin determination system
US20060222640A1 (en) * 2005-03-29 2006-10-05 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for treatment of thrombosis
TWI482628B (zh) * 2007-10-18 2015-05-01 Lundbeck & Co As H 新穎之血栓溶解病患次群
WO2009080054A1 (en) * 2007-12-21 2009-07-02 Ifxa A/S Protease inhibitor
EP3215221B1 (de) 2014-11-03 2020-02-26 Thrombolytic Science, LLC Verfahren und zusammensetzungen zur sicheren und wirksamen thrombolyse
WO2016122288A2 (ko) * 2015-01-30 2016-08-04 고려대학교산학협력단 베르베논 유도체 및 재관류 치료제를 포함하는 뇌혈관 질환, 동맥경화증 또는 심혈관 질환 치료 또는 예방용 병용 제제
RU2622006C2 (ru) * 2015-06-15 2017-06-08 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Казанский (Приволжский) федеральный университет" (ФГАОУВПО КФУ) Применение рекомбинантного штамма bacillus subtilis eo-11 вкпм в-11978 в качестве продуцента субтилизиноподобной протеиназы, вещества с тромболитическими и антикоагулянтными свойствами
CN105396127A (zh) * 2015-11-13 2016-03-16 中国人民解放军第四军医大学 一种用于急性心肌梗死的冠状动脉溶栓剂
US11154596B2 (en) 2017-06-16 2021-10-26 Thrombolytic Science, Llc Methods for thrombolysis

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8508717D0 (en) * 1985-04-03 1985-05-09 Beecham Group Plc Composition
DK43387A (da) † 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
US5084274A (en) * 1987-11-17 1992-01-28 Scripps Clinic And Research Foundation Inhibition of arterial thrombotic occlusion or thromboembolism
DE3804600A1 (de) * 1988-02-13 1989-08-24 Basf Ag Mischung aus einer thrombolytisch wirkenden und einer antithrombotischen substanz
GB8822147D0 (en) * 1988-09-21 1988-10-26 Ciba Geigy Ag Pharmaceutically active combination
US5204323B1 (en) * 1988-10-06 1995-07-18 Ciba Geigy Corp Hirudin antidotal compositions and methods
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3903581A1 (de) * 1989-02-07 1990-08-16 Boehringer Mannheim Gmbh Gewebs-plasminogenaktivator-derivat
CA2064231A1 (en) * 1989-07-20 1991-01-21 John M. Maraganore Combinations and methods for treating or preventing thrombotic diseases
US5240913A (en) * 1989-08-18 1993-08-31 Biogen, Inc. Inhibitors of thrombin
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US5049132A (en) * 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
US5189019A (en) * 1990-04-23 1993-02-23 Merck & Co., Inc. Antistasin derived anticoagulant protein
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
DK0580685T3 (da) † 1991-04-16 1996-03-04 Boehringer Mannheim Gmbh Farmaceutisk emballageenhed indeholdende plasminogenaktivatorer til flerfoldig bolusindgift
JP3559559B2 (ja) † 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体

Also Published As

Publication number Publication date
RU2166326C2 (ru) 2001-05-10
EP0850648A2 (de) 1998-07-01
EP0751785A1 (de) 1997-01-08
WO1995026202A1 (en) 1995-10-05
CA2186390A1 (en) 1995-10-05
EP0751785B1 (de) 1998-06-24
CN1090029C (zh) 2002-09-04
DE69503120T3 (de) 2003-08-14
FI963802A0 (fi) 1996-09-24
DK0751785T4 (da) 2002-04-15
BR9507189A (pt) 1997-09-09
MX9603925A (es) 1997-04-30
AU1951195A (en) 1995-10-17
CZ279596A3 (cs) 1998-01-14
NO316584B1 (no) 2004-03-01
KR100366982B1 (ko) 2003-08-02
EP0751785B2 (de) 2001-12-19
DE69503120T2 (de) 1998-11-12
NO964007L (no) 1996-11-25
NO964007D0 (no) 1996-09-24
AU702470B2 (en) 1999-02-25
US5510330A (en) 1996-04-23
EP0850648A3 (de) 2004-03-31
NZ282417A (en) 1998-02-26
ATE167631T1 (de) 1998-07-15
PL182165B1 (pl) 2001-11-30
FI120182B (fi) 2009-07-31
UA41398C2 (uk) 2001-09-17
DK0751785T3 (da) 1999-04-06
JPH09510439A (ja) 1997-10-21
PL316449A1 (en) 1997-01-20
ES2119411T5 (es) 2002-08-01
CN1144489A (zh) 1997-03-05
FI963802A (fi) 1996-09-24
ES2119411T3 (es) 1998-10-01

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: ROCHE DIAGNOSTICS GMBH, 68305 MANNHEIM, DE

8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: ACTAVIS GROUP PTC EHF., HAFNARFJORDUR, IS

8328 Change in the person/name/address of the agent

Representative=s name: WEICKMANN & WEICKMANN, 81679 MUENCHEN